Might-A-Mins ® Spectrum Isotonix ® Digestive Enzymes Product Symposium 2008 Brooks W. Leigh Scientific Affairs

Might-A-MinsMight-A-Mins®® Spectrum IsotonixSpectrum Isotonix®® Digestive EnzymesDigestive Enzymes

Product Symposium Product Symposium 20082008

Brooks W. LeighBrooks W. LeighScientific AffairsScientific Affairs

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.


DigeZymeDigeZyme® ®

Amylase - starchAmylase - starch Protease - proteinProtease - protein Lipases - fatLipases - fat

Sucrase – sucrose (table sugar)Sucrase – sucrose (table sugar) Maltase – maltose (disaccharide)Maltase – maltose (disaccharide) Papain - proteasesPapain - proteases Bromelain - proteasesBromelain - proteases Caso-Glut – casein and glutenCaso-Glut – casein and gluten Kiwi Protease - actinidinKiwi Protease - actinidin Glutamine – amino acidGlutamine – amino acid

Might-A-MinsMight-A-Mins®® Spectrum Spectrum IsotonixIsotonix®® Digestive Enzymes Digestive Enzymes

Digestion – an overviewDigestion – an overview

DigestionDigestion: the process by which food is : the process by which food is broken up physically, as by the action broken up physically, as by the action of the teeth, and chemically, as by the of the teeth, and chemically, as by the action of enzymes, and converted into action of enzymes, and converted into a substance suitable for absorption a substance suitable for absorption and assimilation into the body.and assimilation into the body.

4 Primary Processes4 Primary Processes1.1. IngestionIngestion

2.2. Mechanical and chemical digestionMechanical and chemical digestion

3.3. AbsorptionAbsorption

4.4. ExcretionExcretion

Digestion – an overviewDigestion – an overview

Example of Enzymatic Example of Enzymatic ActivityActivity

TertiarTertiary y

QuaternaryQuaternary PrimarPrimaryy

EnzymeEnzyme: a biomolecule that increases : a biomolecule that increases the rate of chemical reactions the rate of chemical reactions

Summary of DigestionSummary of Digestion

Polysaccharides (starch, glycogen)

Smaller polysaccharides, maltose

Salivary amylase

Proteins Small polypeptides

Pepsin, HCL

Fats Beginning of fat

degradation

Lingual lipases

Oral Cavity

Stomach



Polysaccharides

Maltose, other polysaccharides

Pancreatic amylases

Polypeptides Smaller polypeptides (2-

3 AA)

Proteases

Fat globules Glycerol, fatty acids

Bile salts, lipases

Disaccharides Monosaccharides

Lactase, sucrase, maltase

Small peptides Amino acids

Proteases

Lumen of small intestine

Epithelium of small intestine


DigeZymeDigeZyme®®:: Proteases → proteins Proteases → proteins Amylases → starchesAmylases → starches Lipases → fatsLipases → fats Cellulase → cellulose (glucose polymers)Cellulase → cellulose (glucose polymers) Lactase → lactose from dairyLactase → lactose from dairy

Sucrase – Sucrase – hydrolyzes sucrose into glucose hydrolyzes sucrose into glucose and fructoseand fructose

Maltase – Maltase – hydrolyzes maltose into two hydrolyzes maltose into two glucose moleculesglucose molecules

Papain – sulfhydryl cysteine protease Papain – sulfhydryl cysteine protease found naturally in papaya fruitfound naturally in papaya fruit Promotes digestion of tough meat fibersPromotes digestion of tough meat fibers High enzymatic activityHigh enzymatic activity

Bromelain – mixture of enzymes found Bromelain – mixture of enzymes found in the pumice and stems of pineapplein the pumice and stems of pineapple Promotes digestion of caseinPromotes digestion of casein Supports a healthy digestive tractSupports a healthy digestive tract


Actinidin – protease found in kiwi fruitActinidin – protease found in kiwi fruitDegrades cysteine residues in proteinsDegrades cysteine residues in proteins

Caso-Glut – unique protease shown to Caso-Glut – unique protease shown to promote the break down of proline-promote the break down of proline-containing proteinscontaining proteins GlutenGluten CaseinCasein

Glutamine – amino acidGlutamine – amino acid Preferred energy source for enterocytesPreferred energy source for enterocytes Supports the preservation of villi barrier Supports the preservation of villi barrier

functionfunction


What are the benefits?What are the benefits?

Supports the absorption and Supports the absorption and utilization of important nutrientsutilization of important nutrients

Supports normal digestionSupports normal digestion Supports the normal digestion of Supports the normal digestion of

grains (gluten) and dairy (casein)grains (gluten) and dairy (casein) Supports a healthy digestive tractSupports a healthy digestive tract Supports normal growth of intestinal Supports normal growth of intestinal

cellscells Promotes stomach comfortPromotes stomach comfort Promotes bowel regularityPromotes bowel regularity

Who Would Benefit? Who Would Benefit? Why?Why?

Enzyme DeficiencyEnzyme Deficiency Stomach DiscomfortStomach Discomfort Bowel IrregularityBowel Irregularity Hyperacidity/Heart BurnHyperacidity/Heart Burn MalabsorptionMalabsorption Food SensitivitiesFood Sensitivities Poor Diet/Processed FoodsPoor Diet/Processed Foods Microbiological StatusMicrobiological Status



Code: Code: 1306913069

DC: DC: $40.00$40.00

SR: SR: $54.95$54.95

BV: 32BV: 32

ReferencesReferences•Borovicka, J., et al. Role of lipase in the regulation of postprandial gastric acid secretion and emptying of fat in humans: a study with orlistat, a highly specific lipase inhibitor. Gut. 46: 774-781, 2000.•Brudnak, M., et al. Enzyme-based therapy for autism spectrum disorders – Is it worth another look? Medical Hypotheses. 58(5): 422-428, 2002.•Caspary, W. Physiology and pathophysiology of intestinal absorption. American Journal of Clinical Nutrition. 55: 299S-308S, 1992.•Du, H., et al. Enzyme therapy for lysosomal acid lipase deficiency in the mouse. Human Molecular Genetics. 10(16): 1639-1648, 2001. •Evans, M., et al. Glutamine prevents cytokine-induced apoptosis in human colonic epithelial cells. Journal of Nutrition. 133(10): 3065-3071, 2003.•Furukawa, S., et al. Glutamine-enhanced bacterial killing by neutrophils from postoperative patients. Nutrition. 13(10): 863-869, 1997.•Horvath, K., et al. Gastrointestinal abnormalities in children with autistic disorder. Journal of Pediatrics. 135(5): 559-563, 1999.•Keller, J. and Layer, P. Human pancreatic exocrine response to nutrients in health and disease. Gut. 54: 1-28, 2005.

ReferencesReferences•Kidd, P. Autism, an extreme challenge to integrative medicine. Part 1: the knowledge base. Alternative Medicine Review. 7(4): 292-316, 2002.•Kidd, P. Autism, an extreme challenge to integrative medicine. Part I1: medical management. Alternative Medicine Review. 7(6): 472-499, 2002.•Levy, S. and Hyman, S. Novel treatments for autistic spectrum disorders. Mental Retardation and Developmental Disabilities Research Reviews. 11: 131-142, 2005.•Miller, A. Therapeutic considerations of L-glutamine: a review of the literature. Alternative Medicine Review. 4(4): 239-48, 1999.•Miller, A. The pathogenesis, clinical implications, and treatment of intestinal hyperpermeability. Alternative Medicine Review. 2(5): 330-345, 1997.•Reeds, P. and Burrin, D. Glutamine and the bowel. Journal of Nutrition. 131: 2505S-2508S, 2001.•White, J. Intestinal pathophysiology in autism. Experimental Biology and Medicine. 228(6): 639-649, 2003.•Yalcin, S., et al. Effect of glutamine supplementation on diarrhea, interleukin-8 and secretory immunoglobulin A in children with acute diarrhea. Journal of Pediatric Gastroenterology and Nutrition. 38(5): 494-501, 2004.

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Might-A-Mins ® Spectrum Isotonix ® Digestive Enzymes Product Symposium 2008 Brooks W. Leigh Scientific Affairs