302

Lefkowitz, R.J. (1983) Proc. Natl Acad. Sci. USA 80, 3173--3177

3 Rosen, O. M., Herrera, R., Olowe, Y., Petruzzelli, L.M. and Cobb, M.H. (1983) Proc. Natl Acad. Sci. USA 80, 3237-3240

4 Jacobs, S., Sahyoun, N. E., Saltiel, A. R. and Cuatrecasas, P. (1983) Proc. Natl Acad. Sci. USA 80, 6211~213

5 Carpenter, G., King, L., Jr and Cohen, S. (1979) J. Biol. Chem. 254, 4884-4891

6 Hunter, T., Ling, N. and Cooper, I. A. (1984) Nature (London) 311, 480-483

7 Poste, G. and Crooke, S.T. (eds) Mechanisms of Receptor Regulation, New Horizons in Therapeutics, Plenum Press, New York (in press)

8 I(aflin, A., Cowburn, D. A. and Relter, M.J. (1973) in Drug Receptors (Rang, H. P., ed.), pp. 193-209, University Park

Press, Baltimore 9 Schweitzer, J.B., Smith, R.M. and

Jarett, L. (1980) Proc. Natl Acad. Sci. USA 77, 4692-4696

10 Jacobs, S. and Cuatrecasas, P. (1980) J. Clin. Invest. 66, 1424-1427

11 Massague, J. and Czech, M. P. (1982) J. Biol. Chem. 257, 6729--6738

12 Maturo, J. M., III and Hollenberg, M. D. (1978) Proc. Natl Acad. Sci. USA 75, 3070-3074

13 Aglio, L., Maturo, J. M. III and Hollen- berg, M. D. J. Cell. Biochem. (in press)

14 Korner, M. K., Gilon, C. and Schramm, M. (1982) J. Biol. Chem. 257, 3389-3396

15 Vauquelin, G., Bottari, S. and Strosberg, A. D. (1980) Mol. Pharmacol. 17, 163-171

16 Rodbell, M. (1980) Nature (London) 284, 17-22

17 Cuatrecasas, P. (1971) J. Biol. Chem. 246,

TIPS - July 1985

6522-6531 18 Armstrong, G.D. and Hollenberg,

M. D. (1985) in Polypeptide Hormone Receptors (Posner, B., ed.), Marcel Dekker, New York, pp. 201-226

19 O'Connor-McCourt, M. and HoUen- berg, M. D. (1983) Can. J. Biochem. Cell Biol. 61, 670-682

20 Ziefler, K. and Rogus, E. M. (1981) Fed. Proc. 40, 121-124

21 Catterall, W. A. (1982) Trends NeuroSci. 5, 3O3--306

22 Goldstein, B. and Wiegel, F. W. (1983) Biophys. J. 43, 121-125

23 Jacobs, S. and Cuatrecasas, P. (1977) Trends Biochem. Sci. 2, 280-282

24 Strittmatter, W. l., Hirata, F. and Axel- rod, I. (1979) Science 204, 1205-1206

25 Hirata, F. and Axelrod, J. (1980) Science 209, 1082-1090

Microcomputers in biology Microcomputers in biology: a practical approach

edited by C . R . Ireland and S .P . Long, IRL Press, 1984. £15.00, US$27.00, (xi + 324 pages) I S B N 0 904147 57 6

As the title suggests, this book aims to provide a practical guide to the use of microcomputers in the biological laboratory. The book is divided into ten chapters, wri t ten by a n u m b e r of practising scientists experienced in the use of microcomputers in their own specialist fields.

The init ial chapters deal with the general problems of laboratory microcomputer systems. The first chapter describes the basic struc- ture of the microcomputer and explains the key terminology for the unini t ia ted, the following two chapters introduce the problem of l inking the microcomputer to laboratory equipment . These chapters provide a great deal of useful information for those about to introduce or extend a laboratory microcomputer system.

The subject of microcomputer graphic facilities is covered in the following chapter. Examples of microcomputer displays accom- pany the text providing a useful insight into the graphic capabili- ties of a typical system.

The remainder of the book is devoted to a description of indi- vidual specialist applications of

the microcomputer in biology. Topics include enzymology, nuc- leic acid sequence analysis, spec- trophotometry, chromatography, centrifugation and the microcom- puter in environmental control.

Each chapter of the book ends with a useful reference section, and most include an appendix containing a number of complete program listings for particular machines. The majority of the programs are writ ten in the ubi- quitous BASIC language, and hence should be fairly easily

adapted for use on different machines. It is unfortunate that some of the program listings are rather difficult to read, since a great deal of information could be gleaned from them. However, all of the programs are available separately on floppy disc (at an additional cost) for a selection of the more popular microcom- puters.

Overall, this book provides a valuable guide to the use of the microcomputer in biology.

ANNE DAWSON

The author is at the Department of Chemical Pathology, University of Leeds, Leeds, UK.

A comprehensive antimalarials text Antimalarial Drugs I: Biological Backgrounds, Experimental Meth- ods and Drug Resistance

edited by W. Peters and W. H. G. Richards, Springer-Verlag, 1984. DM296/$110 .40 (xviii + 484 pages) I S B N 3 540 12616 3

Antimalarial Drugs II: Current Antimalarials and New Drug Developments

edited by W. Peters and W. H. G. Richards, Springer-Verlag, 1984. DM390/$145 .50 (xviii + 520 pages) I S B N 3 540 12617 1

These volumes, though cosily, represent the first comprehensive t reatment of antimalarial chemo- therapy since the early 1970s. At that t ime there were fears about the spread of falciparum malaria resistant to the main therapeutic

drug, chloroquine. This disease was causing problems in S. America and S.E. Asia. Over the last decade this has indeed spread to E. Africa and more recently across Africa to Zambia, Namibia and Angola. The likelihood of this rapid spread follows from the early observation in the rodent malaria Plasmodium yoelii that chloroquine treatment rendered a chloroquine-resistant strain less effective in the mosquito vector.

More than 250 000 drugs have been screened by the Walter Reed Army Institute of Research (WRAIR), Washington, over the last 17 years. Early potential re- placements for chloroquine were the quinol ine and phenanthrene methanols synthesized at the end of the second world war, but these had serious drawbacks. In the early 1970s further quinol ine and phenanthrene methanols became available for testing and two