8/12/2019 Micro Rna and Lung Cancer

1/3

8/12/2019 Micro Rna and Lung Cancer

2/3

n engl j med 352;23 www.nejm.org june 9, 2005

clinical implications of basic research

2447

miRISC

miRISC

AAA

Genomic DNA

mir-84

mir-84let-60

Vulval Development in Worms

Normal Lung Tissue in Humans

Processing

Translational repression

ORF

miRISC

miRISC

AAA

Genomic DNA

let-7

let-7RAS

Processing

Translational repression

ORF

miRISC

RAS

Translation

ORF

??

A

B

C

Copyright 2005 Massachusetts Medical Society. All rights reserved.Downloaded from www.nejm.org on June 10, 2005 . This article is being provided free of charge for use in Indonesia.

8/12/2019 Micro Rna and Lung Cancer

3/3