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Michalska, ATVB, 2012, online
http://www.clinchem.org/content/54/1/24/F1.expansion.html
Endothelial Cells
Leukocyte
Intima
Smooth Muscle Cells
VCAM (on EC)
USPIO
http://nihlibrary.ors.nih.gov/ipdcdb/ipdcdb_main.asp?Page=4
VCAM-binding peptide
P03011
(Contrast Agent for MRI)
(targeting motif)
SECARS?
• Light hits molecule• Molecule energy is shifted
up to virtual energy state• Photon emitted when
molecule drops down in energy
• Anti-Stokes is when energy is less than original
• Allows for high resolution imaging
http://en.wikipedia.org/wiki/Raman_spectroscopy
t1/2 = 4.0±2.4h
t1/2 = 5.0±1.7h
t1/2 = 7.2±2.5h
t1/2 = 6.0±1.3h
Prussian blue stains iron
Spleen pre-injection
Liver pre-injection
Spleen post-injection
Liver post-injection
Lymph post-injection
kidney post-injection
muscle post-injection
Lung post-injection
DAPICD68
Michalska, ATVB, 2012, online
Michalska, ATVB, 2012, online
12 wk
30 wk
Michalska, ATVB, 2012, online
Michalska, ATVB, 2012, online
early plaques
late plaques
Control injection
Michalska, ATVB, 2012, online
Chen, Biomaterials, 2009, 30, 79-88
Chen, Biomaterials, 2009, 30, 79-88
Chen, Biomaterials, 2009, 30, 79-88
Chen, Biomaterials, 2009, 30, 79-88
Chen, Biomaterials, 2009, 30, 79-88
Chen, Biomaterials, 2009, 30, 79-88
Chen, Biomaterials, 2009, 30, 79-88
Chen, Biomaterials, 2009, 30, 79-88
Chen, Biomaterials, 2009, 30, 79-88
Chen, Biomaterials, 2009, 30, 79-88