Upload
jana-mooney
View
41
Download
1
Tags:
Embed Size (px)
DESCRIPTION
MRI-Based Assessment of Neovasculariation in Carotid Plaque – A Novel Risk Marker for Plaque Rupture. Michael Jerosch-Herold, PhD Associate Professor of Radiology Director of Physics for the Cardiac Imaging Program Brigham & Women’s Hospital. - PowerPoint PPT Presentation
Citation preview
MRI-Based Assessment of Neovasculariation in Carotid
Plaque – A Novel Risk Marker for Plaque Rupture
Michael Jerosch-Herold, PhDAssociate Professor of Radiology
Director of Physics for the Cardiac Imaging ProgramBrigham & Women’s Hospital
New 3.0 T Bilateral 8-Channel Carotid Array and Head-Holder for Reynold Carotid Study
Coil mounted on a frame with head-holder consists of two curved paddles
MGH DesignWiggins/Wald
Reference: Hinton-Yates et al., TMRI 2007
8- Coils = pair of four 4.8 cm loops
Head Holder
MRI Protocol for Dynamic Contrast Enhancement
• T1-weighted 3D fast gradient echo– TR/TE/flip angle: 4.3/2.3 ms/ 20°– 3 mm slices– In-plane resolution: 0.7 x 0.7 mm– Time per dynamic view: 14 s
• With new 8-element neck phased array the time per dynamic view is reduced to 10 s.
Post-Processing
Contrast-Enhancement in Carotid Wall
Kinetic Modeling(Kety-Schmidt Model)
Arterial Input Venous Outflow
Tissue Extraction (Ktrans)
vb
Model Parameters Determined by Optimization at Pixel Level• vb vascular volume• Ktrans First order blood-to-tissue transfer rate constant
Measured in vessel lumen
Ktrans Parametric Map
Ktr
ans*
1e3
[1/m
in]
24
20
16
12
8
4
Examp
Ktrans Parametric Map
Ktr
ans*
1e3
[1/s
]
24
20
16
12
8
4
T2 TSE: carotid plaque
Example of Test-Scan in Patient with 8-Channel Phased Array Coil