1
disease status, lifestyle and spiritual change, etc.) were signifi- cantly related to CAM use. Meanwhile, 10 (2.6%) of study re- sults found that geographical regions, health services, health providers or families which the individuals belonged to played an important role on predicting CAM use. The statistical tech- niques currently used in these studies with hierarchal data structure e.g. t-test, univariate or multivariate regression have the risks to exaggerate the standard errors and confidence in- tervals. So that we may not well conclude that there are real associations. Conclusion: Most of the data from current surveys had hierar- chical structures and could not meet the assumption of inde- pendently identically distribution (iid). There were notable methodological limitations in the existing studies. Future re- searches should take account of the clustering structure in their samples, and apply multilevel models to handle the clustered or grouped data to avoid concluding biased results. Contact: Ying Zhang, [email protected] P05.13 Decision Analytic Modeling: An Innovative Tool to Explore the Effectiveness of Acupuncture on Patients in the United States with Lower Back Pain (LBP) P05.14 Method of Drug Discovery in the Classical Tradition of Ayurveda as a Preliminary Tool for Refinement of Folklore Knowledge of Medicinal Plants Ram Manohar (1), Anita Mahapatra (1), Sujithra RM (1), Sujith Eranezhath (1), Aramya AR (1), Mathew Joseph (1), Parvathy Mohan (1) (1) AVP Research Foundation, Coimbatore, Tamil Nadu, India Purpose: The study aims to understand the methods employed by ancient physicians of Ayurveda to discover the medicinal properties of plants and to formally incorporate them into the Ayurvedic Pharmacopoeia. A little more than 1/10th of nearly 9000 plants used for medicinal purposes in India has been used in Ayurveda suggesting the existence of rigorous criteria and methodology for acceptance of medicinal plants. Methods: Twelve classical text books of Ayurveda representing typical chrono-geographical reference points in the evolutionary history of Ayurveda were selected for analysis. These sources were studied for methodological criteria used for rigorous study and acceptance of plant sources as medicines for use in humans. The texts were carefully studied to determine and classify in- formation available on medicinal plants under specific data heads. The minimum, maximum and average time span for ad- dition of new plants into the pharmacopoeia was also determined by study of the selected texts. Results: It was found that Ayurveda employs fairly rigorous methods to evaluate and accept plant sources as medicines. In- adequately understood plants are prohibited from being used as medicines. For accepting a plant source as medicine, elaborate information had to compiled and classified under the data heads of nomenclature, identity, properties and applications of the plant. This includes standardisation of nomenclature, study of varieties, substitutes, pharmacological properties, interactions, safety and specific disease applications. Perhaps Zoopharma- cognosy may have been an important method for first clues of medicinal properties of plants. It took anywhere between 30 years to a few centuries before new plants were added to the Pharmacopoeia suggesting that plant sources were studied for long periods before being accepted as medicines. Conclusion: Classical Ayurvedic texts delineate an early sys- tematic attempt of bioprospecting and development of drugs from plant sources that can be developed as a preliminary tool to filter and refine folklore knowledge of medicinal plants. Contact: Ram Manohar, [email protected] P05.15 Using the Systematic Review Data Repository for Systematic Reviews of Complementary Medicine Nira Hadar (1), Lisa Wieland (1), Eric Manheimer (2), Joseph Lau (1) (1) Brown University, Providence, RI, USA (2) University of Maryland, Baltimore, MD, USA Purpose: The Systematic Review Data Repository (SRDR) is a Web-based open-access tool that supports electronic data extraction and entry by multiple users, data comparison and exporting, and data archiving and sharing. SRDR has the po- tential to reduce the burden of conducting systematic reviews (SRs), while improving data quality and transparency of the process. The development of SRDR is funded by AHRQ and is Abstract Withdrawn A131

Method of Drug Discovery in the Classical Tradition of Ayurveda as a Preliminary Tool for Refinement of Folklore Knowledge of Medicinal Plants

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Page 1: Method of Drug Discovery in the Classical Tradition of Ayurveda as a Preliminary Tool for Refinement of Folklore Knowledge of Medicinal Plants

disease status, lifestyle and spiritual change, etc.) were signifi-cantly related to CAM use. Meanwhile, 10 (2.6%) of study re-sults found that geographical regions, health services, healthproviders or families which the individuals belonged to playedan important role on predicting CAM use. The statistical tech-niques currently used in these studies with hierarchal datastructure e.g. t-test, univariate or multivariate regression havethe risks to exaggerate the standard errors and confidence in-tervals. So that we may not well conclude that there are realassociations.Conclusion: Most of the data from current surveys had hierar-chical structures and could not meet the assumption of inde-pendently identically distribution (iid). There were notablemethodological limitations in the existing studies. Future re-searches should take account of the clustering structure in theirsamples, and apply multilevel models to handle the clustered orgrouped data to avoid concluding biased results.Contact: Ying Zhang, [email protected]

P05.13Decision Analytic Modeling: An Innovative Toolto Explore the Effectiveness of Acupuncture on Patientsin the United States with Lower Back Pain (LBP)

P05.14Method of Drug Discovery in the Classical Traditionof Ayurveda as a Preliminary Tool for Refinementof Folklore Knowledge of Medicinal Plants

Ram Manohar (1), Anita Mahapatra (1), Sujithra RM (1), SujithEranezhath (1), Aramya AR (1), Mathew Joseph (1), ParvathyMohan (1)

(1) AVP Research Foundation, Coimbatore, Tamil Nadu, India

Purpose: The study aims to understand the methods employedby ancient physicians of Ayurveda to discover the medicinalproperties of plants and to formally incorporate them into theAyurvedic Pharmacopoeia. A little more than 1/10th of nearly9000 plants used for medicinal purposes in India has been usedin Ayurveda suggesting the existence of rigorous criteria andmethodology for acceptance of medicinal plants.Methods: Twelve classical text books of Ayurveda representingtypical chrono-geographical reference points in the evolutionaryhistory of Ayurveda were selected for analysis. These sourceswere studied for methodological criteria used for rigorous studyand acceptance of plant sources as medicines for use in humans.The texts were carefully studied to determine and classify in-formation available on medicinal plants under specific dataheads. The minimum, maximum and average time span for ad-dition of new plants into the pharmacopoeia was also determinedby study of the selected texts.Results: It was found that Ayurveda employs fairly rigorousmethods to evaluate and accept plant sources as medicines. In-adequately understood plants are prohibited from being used asmedicines. For accepting a plant source as medicine, elaborateinformation had to compiled and classified under the data headsof nomenclature, identity, properties and applications of theplant. This includes standardisation of nomenclature, study ofvarieties, substitutes, pharmacological properties, interactions,safety and specific disease applications. Perhaps Zoopharma-cognosy may have been an important method for first clues ofmedicinal properties of plants. It took anywhere between 30years to a few centuries before new plants were added to thePharmacopoeia suggesting that plant sources were studied forlong periods before being accepted as medicines.Conclusion: Classical Ayurvedic texts delineate an early sys-tematic attempt of bioprospecting and development of drugsfrom plant sources that can be developed as a preliminary tool tofilter and refine folklore knowledge of medicinal plants.Contact: Ram Manohar, [email protected]

P05.15Using the Systematic Review Data Repositoryfor Systematic Reviews of Complementary Medicine

Nira Hadar (1), Lisa Wieland (1), Eric Manheimer (2), JosephLau (1)

(1) Brown University, Providence, RI, USA(2) University of Maryland, Baltimore, MD, USA

Purpose: The Systematic Review Data Repository (SRDR) isa Web-based open-access tool that supports electronic dataextraction and entry by multiple users, data comparison andexporting, and data archiving and sharing. SRDR has the po-tential to reduce the burden of conducting systematic reviews(SRs), while improving data quality and transparency of theprocess. The development of SRDR is funded by AHRQ and is

Abstract Withdrawn

A131