782 Book Reviews Hypoxia, Metabolic Acidosis and the Ch'ealatiea---Edited by A. I. Arieff. 215pp. 1992. Oxford University Press, New York, £45. (American Physiological Society Clinical Physiology Series.) The heart, lungs, and blood vessels are affected by hypoxia (H) to differing extents. This volume discusses; circulatory regulation during H; regulation of myocardial blood flow; acid base status and blood lactate at extreme altitude; effects of H on normal and hypertrophied hearts; pathophysiology of defects in lactate disposal; acidosis and pulmonary circu- lation; pathogenesis of metabolic acidosis with H; effects of sodium bicarbonate on myocardial metabolism; alkalinizing agents for treatment of cardiac arrest; therapy of lactate acidosis---alternatives to sodium bicarbonate. Cell Biology; Labfax--Edited by G. B. Dealtry and D. Rickwood. 254 pp. 1992. Blackwell Scientific Publications, Oxford, £24.95. This is a volume in the series that includes volumes on Molecular Biology, and Cell Culture. It provides numerical data and tables useful to cell biologists. The topics dealt with are; solutions used in cell biology; subceUular fractionation; fight microscopy; electron microscopy; DNA and chromo- somes of cells; composition and structure of membranes; membrane transport mechanisms; cell surface receptors; inhibitors; cyclic nucleotides; steroid hormones; peptide hormones; growth regulators; cell cycle; oncogenes; cen- trifugation; radioisotopes. Most laboratories will find this a useful book. Metals in Biological System~--M. J. Kendrick, M. T. May, M. J. Plishka and K. D. Robinson. 183pp. 1992. Ellis Horwood/Prentice Hall, New York. This book provides the bio-inorganic chemistry approach to the study of the metal systems. In most systems the ground state of the catalyst is altered sterically or electronically to yield a higher energy state. This ground state is close to the activated complex so that one can overcome the activation barrier without lowering the energy of activation. The enstatic state shows an increase in energy of the ground state, called the strain energy. The chapters deal with structural and physical methods of characterising metal centers in nature; the role of the different elements in biological systems; calcium, magnesium, sodium, cobalt, manganese, copper, iron, molybdenum, tungsten, va- nadium, aluminium, chromium, zinc, nickel; drugs contain- ing inorganic elements (Ag, Hg, Au, B, Ca, Co, Cu, F, Fe, Gd, Li, N, Pt, Sn, Tc).

Metals in biological systems: M. J. Kendrick, M. T. May, M. J. Plishka and K. D. Robinson. 183 pp. 1992. Ellis Horwood/Prentice Hall, New York

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Page 1: Metals in biological systems: M. J. Kendrick, M. T. May, M. J. Plishka and K. D. Robinson. 183 pp. 1992. Ellis Horwood/Prentice Hall, New York

782 Book Reviews

Hypoxia, Metabolic Acidosis and the Ch'ealatiea---Edited by A. I. Arieff. 215pp. 1992. Oxford University Press, New York, £45. (American Physiological Society Clinical Physiology Series.)

The heart, lungs, and blood vessels are affected by hypoxia (H) to differing extents. This volume discusses; circulatory regulation during H; regulation of myocardial blood flow; acid base status and blood lactate at extreme altitude; effects of H on normal and hypertrophied hearts; pathophysiology of defects in lactate disposal; acidosis and pulmonary circu- lation; pathogenesis of metabolic acidosis with H; effects of sodium bicarbonate on myocardial metabolism; alkalinizing agents for treatment of cardiac arrest; therapy of lactate acidosis---alternatives to sodium bicarbonate.

Cell Biology; Labfax--Edited by G. B. Dealtry and D. Rickwood. 254 pp. 1992. Blackwell Scientific Publications, Oxford, £24.95.

This is a volume in the series that includes volumes on Molecular Biology, and Cell Culture. It provides numerical data and tables useful to cell biologists. The topics dealt with are; solutions used in cell biology; subceUular fractionation; fight microscopy; electron microscopy; DNA and chromo-

somes of cells; composition and structure of membranes; membrane transport mechanisms; cell surface receptors; inhibitors; cyclic nucleotides; steroid hormones; peptide hormones; growth regulators; cell cycle; oncogenes; cen- trifugation; radioisotopes. Most laboratories will find this a useful book.

Metals in Biological System~--M. J. Kendrick, M. T. May, M. J. Plishka and K. D. Robinson. 183pp. 1992. Ellis Horwood/Prentice Hall, New York.

This book provides the bio-inorganic chemistry approach to the study of the metal systems. In most systems the ground state of the catalyst is altered sterically or electronically to yield a higher energy state. This ground state is close to the activated complex so that one can overcome the activation barrier without lowering the energy of activation. The enstatic state shows an increase in energy of the ground state, called the strain energy. The chapters deal with structural and physical methods of characterising metal centers in nature; the role of the different elements in biological systems; calcium, magnesium, sodium, cobalt, manganese, copper, iron, molybdenum, tungsten, va- nadium, aluminium, chromium, zinc, nickel; drugs contain- ing inorganic elements (Ag, Hg, Au, B, Ca, Co, Cu, F, Fe, Gd, Li, N, Pt, Sn, Tc).