METABOLIC DISEASES.

CALCIFICATION.

PIGMENTATION.

III. practical training

3rd year General Medicine

Atherosclerosis

calcification

fibrosis

Atherosclerosis Crystals of cholesterol in atheromatous plaque of arterial wall (negative

picture of washed up crystals)

Miliary tuberculosis – lung

Intradermal naevocellular naevus

Intradermal naevocellular naevus

Pathologic pigmentation of skin, defect of melanin-

vitiligo

1 normal distribution of melanin

in basal layer

2 defect of melanin in basal layer

2

1

Pathologic pigmentation of skin, defect of melanin-

vitiligo, impregnation of melanin by silver according to

Masson

1 normal distribution of melanin

in basal layer

2 defect of melanin in basal layer

1 2

Malignant melanoma

Malignant melanoma

Malignant melanoma

Malignant melanoma

Melanin in tumour cells

(lentigo maligna melanoma)

1

1

2

1 Melanin in tumour cells

2 Melanin fagocyted in

histiocytes (released from

tumour cells)

3 layer of keratinization in

epidermis

3

Nodular melanoma

Atrophy of the heart muscle

Haemosiderosis of liver

special staining of iron according Perls

Haemachromatosis of pancreas

special staining of iron according Perls

Biliary nephrosis

Biliary cirrhosis

Biliary cirrhosis (special staining of bile according Fouchet)

Antracosis of the lungs

1 antracotic pigment in

interalveolar septa indurated lung

2 clusters of siderophages

3 lumen of artery

1

2

2

3

Antracosis of the lungs

1 capsule of lymph node

2 lymphatic follicles

3 medullar sinus

4 antracophages in medulla of lymph node

5 lung tissue

1

2

2

3

4

5

Asbestosis of the lungs

copy

Silicosis of the lungs

1

1

1

1 fibrous centre of nodul

Silicosis of the lungs

kopie

1

1 fibrous centre of nodul

2 blending of alveoli (perifocal

emphysema)

2

2

2

Silicosis of the lungs

copy

Silicosis of the lungs– early stage (mostly in macrophages) silica crystals in polarized light

copy