Keystone Symposia on Molecular and Cellular Biology is a nonprofit organization headquartered in Colorado, USA directed and supported by the scientific community.

Keystone Symposia is pleased to present

Metabolic Control of Inflammation and ImmunityScientific Organizers: Vishva M. Dixit, Douglas R. Green and Maya Saleh

January 21–26, 2013 | Beaver Run Resort | Breckenridge, Colorado, USA

Inflammation and immune responses are energetically costly, as are the infections that elicit them. The interplay of these metabolic demands are complex, and frequently “hard-wired”

into the responses. An emerging field is illuminating this interplay of metabolism, inflammation and immunity. This meeting will uniquely bring together scientists who study inflammation and immunity to encounter their “metabolic” counterparts from other fields. While mutations in the NOD sensors have been associated with relatively rare periodic fever syndromes, there is newfound interest in them with the realization that one member (NOD2) is the most commonly mutated gene in inflammatory bowel disease (IBD). Further, there has been the recent insight that mutations in other IBD susceptibility genes, such as ATG16L, lead to activation of the inflammasome, possibly due to a deficit in autophagic efficiency and consequent increase in reactive oxygen species that trigger a NOD sensor. Superimposed on this exciting insight has been the understanding that the NOD sensors also respond to metabolic stress, the hallmark of disease states such as type 2 diabetes. Inflammasome-mediated inflammation, likely drives insulin resistance as suggested by a recent clinical trial where neutralizing IL-1b led to a decrease in systemic markers of inflammation and improved glycemic control. Other recently emergent data concerns the interplay of metabolism and the innate and adaptive immune responses. Together, these developments have dramatically underscored the importance of inflammation and immunity in metabolic disease states – which will be further explored in-depth at this conference.

Session Topics: > Metabolism and Signaling > The Inflammasome and Metabolism > Inflammation and Metabolism > NOD, Microbiota and Metabolism > Mitochondria, Inflammation and Metabolism > Metabolic Control of Adaptive Immunity > Cell Death, Immunity and Metabolism

Abstract & Scholarship Deadline: September 24, 2012Late-Breaking Abstract Deadline: October 24, 2012Early Registration Deadline: November 19, 2012

Note: Scholarships are available to students and postdoctoral fellows and require a brief application and submission of an abstract. Short talk speakers will also be selected from abstracts. Early registration saves US$150 on later fee. Information shown is subject to possible change. Please visit meeting website for the most up-to-date program information.

www.keystonesymposia.org/13A9

Keystone Symposia on Molecular and Cellular Biology is a nonprofit organization headquartered in Colorado, USA directed and supported by the scientific community.

1.970.262.1230 | 1.800.253.0685 (US & Canada)

MONDAY, JANUARY 21

Arrival and Registration

TUESDAY, JANUARY 22

Welcome and Keynote Address *Vishva M. Dixit, Genentech, Inc., USA*Douglas R. Green, St. Jude Children's Research Hospital, USARichard A. Flavell, Yale University School of Medicine, USAInflammasome, Microbiota and Disease

Metabolism and Signaling *Thirumala-Devi Kanneganti, St. Jude Children's Research Hospital,USARonald M. Evans, The Salk Institute, USANuclear Receptor Control of Rhythm and MetabolismMatthew G. Vander Heiden, Massachusetts Institute of Technology,USARegulation of Cell Metabolism to Support ProliferationAjay Chawla, University of California, San Francisco, USAInnate Control of MetabolismMitchell A. Lazar, University of Pennsylvania School of Medicine, USABattle of the Master Regulators PPARgamma and PU.1Holly Legault, Biogen Idec, USAShort Talk: IRAK4 Inhibition Results in Amelioration of Disease inDiet-Induced Obesity ModelShannon Marie Reilly, University of Michigan, USAShort Talk: An Inhibitor of the Protein Kinases TBK1/IKKe ImprovesObesity-Related Metabolic Dysfunctions

The Inflammasome and Metabolism I *Ronald M. Evans, The Salk Institute, USAVishva M. Dixit, Genentech, Inc., USANon-Canonical Inflammasome Activation Targets Caspase-11Jenny P.-Y. Ting, University of North Carolina at Chapel Hill, USAFatty Acid-Induced NLRP3 InflammasomeThirumala-Devi Kanneganti, St. Jude Children's Research Hospital,USANlrp3 Inflammasome in DiabetesEicke Latz, University of Massachusetts Medical School, USAInflammasome Activation in Atherosclerosis and Alzheimer's Disease

Poster Session 1

WEDNESDAY, JANUARY 23

The Inflammasome and Metabolism II *Steven E. Shoelson, Harvard Medical School, Joslin DiabetesCenter, USACharles A. Dinarello, University of Colorado Health Sciences Center,USAHow Does the IL-1 Family Control its Own Members?Luke A. J. O'Neill, Trinity College Dublin, IrelandMetabolic Control of Innate Immunity and InflammationMarc Y. Donath, University Hospital Basel, SwitzerlandIslet Inflammation in Type 2 and Diabetes

Vishwa Deep Dixit, Pennington Biomedical Research Center, LSUSystem, USAInflammasomes and the Regulation of HealthspanMenno P.J. de Winther, Academic Medical Center, NetherlandsShort Talk: Myeloid IL-10R1 Deficiency Attenuates Atherosclerosis inHyperlipidemic LDLR-/- MiceDov Ben Ballak, Radboud University Medical Centre, NetherlandsShort Talk: A Novel IL-1 Family Member: Anti-Inflammatory Actions ofIL-37 Protect Against Obesity-Induced Inflammation and InsulinResistance

Inflammation and Metabolism *Luke A. J. O'Neill, Trinity College Dublin, IrelandGökhan S. Hotamisligil, Harvard University, USAMechanisms of Metabolic Inflammation and ER DysfunctionTiffany Horng, Harvard School of Public Health, USAShort Talk: A Critical Role for Calcium Mobilization in Activation of theNLRP3 InflammasomeDa Young Oh, University of California, San Diego, USAShort Talk: Differential Role of Kupffer Cell vs. Recruited HepaticMacrophage on Liver Insulin ResistanceSteven E. Shoelson, Harvard Medical School, Joslin DiabetesCenter, USATargeting Inflammation in Insulin Resistance and DiabetesGreg Steinberg, McMaster University, CanadaShort Talk: AMP-Activated Protein Kinase (AMPK) Links LipidMetabolism with Innate Immunity and the Therapeutic Effects ofSalicylate

Poster Session 2

THURSDAY, JANUARY 24

NOD, Microbiota and Metabolism *Kate A. Fitzgerald, University of Massachusetts Medical School, USAMaya Saleh, McGill University, CanadaNOD-Mediated InflammationStephen E. Girardin, University of Toronto, CanadaInvasive Bacteria, mTOR and Amino Acid StarvationHerbert (Skip) W. Virgin IV, Washington University School ofMedicine, USAAutophagy in Inflammation and DiseaseGabriel Nuñez, University of Michigan, USAMetabolic Control of Pathogen Eradication by the Gut Microbiota Jonathan D. Schertzer, McMaster University, CanadaShort Talk: Immunometabolism of NOD1 and NOD2: Yin and Yang ofInsulin Resistance during ObesityJanelle S. Ayres, The Salk Institute, USAShort Talk: Microbiota Control of Wasting Associated withInflammation and Infection

Mitochondria, Inflammation and Metabolism *Gabriel Nuñez, University of Michigan, USAKate A. Fitzgerald, University of Massachusetts Medical School, USACytosolic Immune Surveillance

* Session Chair  † Invited but not yet accepted     Program current as of December 13, 2012. Program subject to change. Meal formats are based on meeting venue.For the most up-to-date details, visit www.keystonesymposia.org/13A9.

KEYSTONE SYMPOSIAon Molecular and Cellular Biology

Metabolic Control of Inflammation and Immunity (A9)January 21-26, 2013 •  Beaver Run Resort •  Breckenridge, Colorado, USAScientific Organizers: Vishva M. Dixit, Douglas R. Green and Maya Saleh

Sponsored by EMD Millipore Abstract & Scholarship Deadline: September 24, 2012 / Late-Breaking Abstract Deadline: October 24, 2012 / Early Registration Deadline: November 19, 2012

Fraser Soares, University of Toronto, CanadaShort Talk: Investigating the Role of NLRX1 in Innate ImmunityRichard M. Siegel, NIAMS, National Institutes of Health, USAMitochondrial ROS: Fuel for the Fire of AutoinflammationChih-hao Chang, Washington University in St Louis, USAShort Talk: Specific Control of T Cell Effector Function by WarburgMetabolism

FRIDAY, JANUARY 25

Metabolic Control of Adaptive Immunity *Michael Karin, University of California, San Diego, USADrew M. Pardoll, Johns Hopkins University School of Medicine, USAHIF1 in the Treg/Th17 AxisJonathan D. Powell, Johns Hopkins University School of Medicine,USAmTOR Regulation of T Cell FunctionDouglas R. Green, St. Jude Children's Research Hospital, USANo Free Lunches: LC3-Associated Phagocytosis, a Process that LinksPhagocytosis and Autophagy, and its Possible Roles in Inflammation,Innate Immunity, and Homeostasis Jeffrey C. Rathmell, Duke University, USAGlucose Metabolism in T Cell Activation and CD4 SubsetsLaura J. Dixon, Case Western Reserve University, USAShort Talk: Role of Caspase-1 in High Fat-Induced Non-AlcoholicSteatohepatitis in Mice Tim Hendrikx, Maastricht University, NetherlandsShort Talk: Caspase-1 as a Novel Target for the Detection andTreatment of Non-Alcoholic Steatohepatitis

Cell Death, Immunity and Metabolism *Drew M. Pardoll, Johns Hopkins University School of Medicine, USAMichael Karin, University of California, San Diego, USANF-kappaB, Inflammation and MetabolismKodi S. Ravichandran, University of Virginia, USAApoptotic Cell Clearance and the Phagocyte MetabolismNika N. Danial, Dana-Farber Cancer Institute, USAA Role for Bcl2 Family Members in DiabetesRachel J. Roth Flach, University of Massachusetts Medical School,USAShort Talk: MAP4K4 Is a Novel Regulator of Vascular Inflammation inInsulin Resistance and Atherosclerosis

SATURDAY, JANUARY 26

Departure

* Session Chair  † Invited but not yet accepted     Program current as of December 13, 2012. Program subject to change. Meal formats are based on meeting venue.For the most up-to-date details, visit www.keystonesymposia.org/13A9.

KEYSTONE SYMPOSIAon Molecular and Cellular Biology

Metabolic Control of Inflammation and Immunity (A9)January 21-26, 2013 •  Beaver Run Resort •  Breckenridge, Colorado, USAScientific Organizers: Vishva M. Dixit, Douglas R. Green and Maya Saleh

Sponsored by EMD Millipore Abstract & Scholarship Deadline: September 24, 2012 / Late-Breaking Abstract Deadline: October 24, 2012 / Early Registration Deadline: November 19, 2012