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MEMORY
A journey from the mind to the molecules
- Mr. Arjun Maitra- Assistant Professor
Dept. of Physiology
PCMS&RC
TO MY STUDENTS
HERE I HAVE TRIED TO SIMPLIFY THE HUGE SUBJECT WITH ANIMATIONS, DIAGRAMS, FLOW CHARTS & RELEVENT MCQs.DIFFERENT TEXT BOOKS AND REFERENCE BOOKS HAVE BEEN USED FORPREPARING THE CONTENTS. REMEMBERTHESE SLIDES ARE NOT THE SUBSTITUTE OF YOUR TEXT BOOKS
ANIMATIONS AND DIAGRAMS ARE COLLECTED FROM DIFFERENT WEBSITESOLELY FOR EDUCATION PURPOSE.
Eric. R. Kandel (MD)Nobel Prize :2000 (Physiology)
Nobel Lecture:
The Molecular Biology of Memory Storage: A Dialog between Genes and Synapses
In the Beginning there was...
MemoryBut it soon became apparent that not all memory was created equal…
• What’s your mother’s name? • What did you have for lunch today?
Yesterday? Two days ago?
• What color is the car you’re parked next to?
• How do you ride a bike?
Memory
sensory short term long term
workingiconic echoic
phonol.loop
v-ssketchpad
CentralExec
phon. store rehearsal
declarative(explicit)
non-decl.(implicit)
facts events
skillshabits
priming
class. cond.
...
HOW MEMORY IS BUILT::::::::::::::
A
P
L
A
N
F
O
R
A
LAY MAN
AREAS OF BRAIN ASSOCIATED WITH MEMORY
WHERE IS THE HARD DISK HIDDEN IN THE BRAIN
WHERE WAS THE ELEPHANT HIDING IN SIDE BRAIN
“ELEPHANT” LEFT MEDIAL TEMPORAL LOBE
VISUAL CUES OCCIPITAL LOBE AND SURROUNDIG AREA
RECOGNITION LEFT OCCIPITO TEMPORAL CORTEX
NAMING LEFT MEDIAL TEMPORAL LOBE
HAMMER INSIDE THE HEAD
“HAMMER” POSTERIOR PARIETAL CORTEX
NAMING LEFT PREMOTOR AREA + LEFT MIDDLE TEMPORAL GYRUS
HIPPOCAMPAL FORMATION
&PATHWAYS
HOW DO WE RECOGNISES FACES
OCCIPITAL CORTEXVISUAL ASSOCIATION AREA INFEROTEMPORAL CORTEX
MESO TEMPORAL ASSOCIATION CORTEX
PARA HIPPOCAMPALCORTEX
PERIHINAL CORTEX
ENTORHINAL CORTEX
PERFORANT PATHWAY
HIPPOCAMPUS
MEDIALTEMPORAL LOBE
HOW MEMORY FOR A FACE IS REGISTERED
NOW HOW THE MEMORY IS RETRIEVED IN TERMS OF NEURAL NETWORK
entorhinal cortex → perforant path → dentate gyrus → mossy fibres → CA3 → Schaffer collaterals (and a big projection via the fimbria to the contralateral hippocampus) → CA1 → alveus → entorhinal cortex
SOME GENES RELATED TO MEMORY
HCN 1
zif268
c-fos
arc
Homer
NOW THINK BEFORE YOU START
REMEMBERING A FEW THINGS
FROM THIS SEMINAR