Dr. Stefanos Bonovas Curriculum Vitae

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Stefanos Bonovas, MD, MSc, PhD

Medical Epidemiologist - Biostatistician

Hellenic Centre for Disease Control and Prevention

Dr. Stefanos Bonovas Curriculum Vitae

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CURRICULUM VITAE

Name / Surname:

Stefanos Bonovas

Current position:

Head, Department of Epidemiological Surveillance and Intervention,

Hellenic Centre for Disease Control and Prevention, Athens, Greece.

Education:

10/1991 – 07/1997 University of Athens, School of Medicine.

06/1998 – 06/2002 Specialty training program in General Practice,

General Hospital of Athens " G. Genimmatas ", Athens, Greece.

09/2000 – 11/2002 Master of Science (M.Sc.) in Biostatistics,

University of Athens (School of Medicine & Department of Mathematics)

and University of Ioannina (Department of Mathematics).

11/2002 M.Sc. thesis: " The epidemiology of antibiotic resistance in hospitals "

06/2004 – 11/2007 Ph.D. in Pharmacoepidemiology,

University of Athens, School of Medicine, Department of Pharmacology.

Title: " Cancer Chemoprevention: Meta-analyses of Clinical Trials and Observational

Studies in Epidemiology "

Grade: Excellent, defended and awarded in 2007.

Research interests:

- Infectious disease epidemiology

- Pharmacoepidemiology

- Cancer chemoprevention

- Meta-analysis

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Peer-reviewed publications: >60.

Citations: >600.

List of peer-reviewed publications:

1. Bonovas S, Nikolopoulos G, Filioussi K, Peponi E, Bagos P, Sitaras NM. Can statin therapy reduce the risk of melanoma? A meta-analysis of randomized controlled trials. European Journal of Epidemiology 2010; 25: 29–35.

2. Bonovas S, Filioussi K, Sitaras NM. Statins are not associated with a reduced risk of

pancreatic cancer at the population level, when taken at low doses for managing hypercholesterolemia: evidence from a meta-analysis of 12 studies. American Journal of Gastroenterology 2008; 103: 2646–2651.

3. Bonovas S, Tsantes A, Drosos T, Sitaras NM. Cancer chemoprevention: a summary of

the current evidence. Anticancer Research 2008; 28: 1857–1866. 4. Bonovas S, Filioussi K, Sitaras NM. Statin use and the risk of prostate cancer: a meta-

analysis of 6 randomized clinical trials and 13 observational studies. International Journal of Cancer 2008; 123: 899–904.

5. Bonovas S, Filioussi K, Tsantes A, Sitaras NM. Use of statins and risk of haematological

malignancies: a meta-analysis of six randomized clinical trials and eight observational studies. British Journal of Clinical Pharmacology 2007; 64: 255–262.

6. Bonovas S, Filioussi K, Flordellis CS, Sitaras NM. Statins and the risk of colorectal

cancer: a meta-analysis of 18 studies involving more than 1.5 million subjects. Journal of Clinical Oncology 2007; 25: 3462–3468. (accompanied by Editorial in the same journal issue)

7. Bonovas S, Sitaras NM. Does pravastatin promote cancer in elderly patients? A meta-

analysis. Canadian Medical Association Journal 2007; 176: 649–654. (accompanied by Editorial in the same journal issue)

8. Bonovas S, Filioussi K, Tsavaris N, Sitaras NM. Statins and cancer risk: a literature-

based meta-analysis and meta-regression analysis of 35 randomized controlled trials. Journal of Clinical Oncology 2006; 24: 4808–4817. (accompanied by Editorial in the same journal issue)

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9. Bonovas S, Filioussi K, Sitaras NM. Paracetamol use and ovarian cancer risk: a meta-

analysis. British Journal of Clinical Pharmacology 2006; 62: 113–121. (accompanied by Press Release issued by Blackwell Publishing Ltd)

10. Bonovas S, Filioussi K, Tsavaris N, Sitaras NM. Use of Statins and breast cancer: a

meta-analysis of seven randomized clinical trials and nine observational studies. Journal of Clinical Oncology 2005; 23: 8606–8612. (accompanied by Editorial in the same journal issue)

11. Bonovas S, Filioussi K, Sitaras NM. Do non-steroidal anti-inflammatory drugs affect the

risk of developing ovarian cancer? A meta-analysis. British Journal of Clinical Pharmacology 2005; 60: 194–203. (accompanied by Editorial in the same journal issue)

12. Bonovas S, Filioussi K, Tsantes A. Diabetes mellitus and risk of prostate cancer: a meta-

analysis. Diabetologia 2004; 47: 1071–1078. 13. Bonovas S, Peponis V, Filioussi K. Diabetes mellitus as a risk factor for primary open-

angle glaucoma: a meta-analysis. Diabetic Medicine 2004; 21: 609–614. 14. Bonovas S, Filioussi K, Tsantes A, Peponis V. Epidemiological association between

cigarette smoking and primary open-angle glaucoma: a meta-analysis. Public Health 2004; 118: 256–261.

15. Bonovas S, Panagiotakos DB, Charalambides C, Vatopoulos A. Mathematical models for

the evaluation of antibiotic resistance in hospitals: a systematic review. Central European Journal of Public Health 2003; 11: 229–237.

16. Bonovas S, Sitaras NM. Anti-inflammatory agents in ageing and age-associated diseases.

Anti-Inflammatory and Anti-Allergy Agents in Medicinal Chemistry 2006; 5: 365–373. 17. Bonovas S. Cancer chemoprevention: progress and perspectives [editorial]. Current

Drug Targets 2010; [Epub ahead of print]. 18. Nikolopoulos GK, Bagos PG, Bonovas S. Developing the evidence base for cancer

shemoprevention: use of meta-analysis. Current Drug Targets 2010; [Epub ahead of print].

19. Nikolopoulos G, Bagos P, Lytras T, Bonovas S. An ecological study of the determinants

of differences in 2009 pandemic influenza mortality rates between countries in Europe. PLoS One 2011; 6: e19432. (accompanied by Press Release issued by Public Library of Science)

20. Karagiannis I, Sideroglou T, Gkolfinopoulou K, Tsouri A, Lampousaki D, Velonakis

EN, Scoulica EV, Mellou K, Panagiotopoulos T, Bonovas S. A waterborne Campylobacter jejuni outbreak on a Greek island. Epidemiology and Infection 2010; 138: 1726–1734.

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21. Karagiannis I, Detsis M, Gkolfinopoulou K, Pervanidou D, Panagiotopoulos T,

Bonovas S. An outbreak of gastroenteritis linked to seafood consumption in a remote Northern Aegean island, February–March 2010. Rural and Remote Health 2010; 10: 1507.

22. Lytras T, Theocharopoulos G, Tsiodras S, Mentis A, Panagiotopoulos T, Bonovas S.

Enhanced surveillance of influenza A(H1N1)v in Greece during the containment phase. Eurosurveillance 2009; 14: pii=19275.

23. Sypsa V, Bonovas S, Tsiodras S, Baka A, Efstathiou P, Malliori M, Panagiotopoulos T,

Nikolakopoulos I, Hatzakis A. Estimating the disease burden of 2009 pandemic influenza A(H1N1) from surveillance and household surveys in Greece. PLoS One 2011; 6: e20593.

24. Panagiotopoulos T, Bonovas S, Danis K, Iliopoulos D, Dedoukou X, Pavli A, Smeti P,

Mentis A, Kossivakis A, Melidou A, Diza E, Chatzidimitriou D, Koratzanis E, Michailides S, Passalidou E, Kollaras P, Nikolaides P, Tsiodras S. Cluster of new influenza A(H1N1) cases in travellers returning from Scotland to Greece – community transmission within the European Union? Eurosurveillance 2009; 14: pii=19226.

25. Nikolopoulos G, Bonovas S, Tsantes A, Sitaras NM. HIV/AIDS: Recent advances in

antiretroviral agents. Mini Reviews in Medicinal Chemistry 2009; 9: 900–910. 26. Tsantes A, Bonovas S, Travlou A, Sitaras NM. Redox imbalance, macrocytosis, and RBC

homeostasis. Antioxidants & Redox Signaling 2006; 8: 1205–1216. 27. Kopterides P, Bonovas S, Mavrou I, Kostadima E, Zakynthinos E, Armaganidis A.

Venous oxygen saturation and lactate gradient from superior vena cava to pulmonary artery in patients with septic shock. Shock 2009; 31: 561–567.

28. Peponis V, Bonovas S, Kapranou A, Peponi E, Filioussi K, Magkou C, Sitaras NM.

Conjunctival and tear film changes after vitamin C and E administration in non-insulin dependent diabetes mellitus. Medical Science Monitor 2004; 10: 213–217.

29. Tsantes A, Bonovas S, Tassiopoulos S, Filioussi K, Vlachou A, Meletis J, Papadhimitriou

S, Vaiopoulos G. A comparative study of the role of erythropoietin in the pathogenesis of deficient erythropoiesis in idiopathic pulmonary fibrosis as opposed to chronic obstructive pulmonary disease. Medical Science Monitor 2005; 11: 177–181.

30. Filioussi K, Bonovas S, Katsaros T. Should we screen diabetic patients taking biguanides

for megaloblastic anaemia? Australian Family Physician 2003; 32: 383–384. 31. Vavetsi R, Bonovas S, Polizou P, Papanastasopoulou C, Dougekou G, Sitaras NM. The

diagnostic role of glycosaminoglycans in pleural effusions: a pilot study. BMC Pulmonary Medicine 2009; 9: 9.

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32. Papadopoulos IN, Bonovas S, Kanakaris N, Konstantiadou I, Nikolopoulos G, Konstantoudakis G, Leukidis C. Motor vehicle collision fatalities involving alcohol and illicit drugs in Greece: the need for management protocols and a reassessment of surveillance. Addiction 2010; 105: 1952–1961.

33. Papadopoulos IN, Bonovas S, Kanakaris N, Nikolopoulos G, Kotsilianou O,

Konstantoudakis G, Leukidis C. Alcohol and psychoactive drugs increased the pre-hospital mortality in 655 fall-related fatalities in Greece: a call for management protocols. Injury 2010; [Epub ahead of print].

34. Papadopoulos IN, Kanakaris N, Bonovas S, Konstantoudakis G, Petropoulou K,

Christodoulou S, Kotsilianou O, Leukidis C. Patients with pelvic fractures due to falls: a paradigm that contributed to autopsy-based audit of trauma in Greece. Journal of Trauma Management and Outcomes 2011; 5: 2.

35. Papadopoulos IN, Kanakaris N, Bonovas S, Triantafillidis A, Garnavos C, Voros D,

Leukidis C. Auditing 655 fatalities with pelvic fractures by autopsy as a basis to evaluate trauma care. Journal of the American College of Surgeons 2006; 203: 30–43.

36. Peponis V, Chalkiadakis SE, Bonovas S, Sitaras NM. The controversy over the

association between statins use and progression of age-related macular degeneration: a mini review. Clinical Ophthalmology 2010; 4: 865–869.

37. Tsantes A, Androutsos G, Bonovas S, Vogiatzi D, Meletis I, Stamou E, Stamoulakatou

A, Paterakis G. Assessment of a new immunocytochemical technique in HbF-cell counting by a novel objective evaluation method. British Journal of Haematology 2003; 123: 948–951.

38. Tsangaris I, Tsantes A, Bonovas S, Lignos M, Kopterides P, Gialeraki A, Rapti E,

Orfanos S, Dimopoulou I, Travlou A, Armaganidis A. The impact of the PAI-1 4G/5G polymorphism on the outcome of patients with ALI/ARDS. Thrombosis Research 2009; 123: 832–836.

39. Tsantes A, Tsangaris I, Bonovas S, Kopterides P, Rapti E, Dimopoulou I, Markatos C,

Orfanos S, Armaganidis A, Travlou A. The effect of four hemostatic gene polymorphisms on the outcome of septic critically ill patients. Blood Coagulation and Fibrinolysis 2010; 21: 175–181.

40. Tsantes A, Dimoula A, Bonovas S, Mantzios G, Tsirigotis P, Zoi K, Kalamara E,

Kardoulaki A, Sitaras N, Travlou A, Dervenoulas J, Vaiopoulos G. The role of the Platelet Function Analyzer (PFA)–100 and platelet aggregometry in the differentiation of essential thrombocythemia from reactive thrombocytosis. Thrombosis Research 2010; 125: 142–146.

41. Tsantes A, Tassiopoulos S, Papadhimitriou SI, Bonovas S, Kavalierou L, Vaiopoulos G,

Meletis I. Suboptimal erythropoietic response to hypoxemia in idiopathic pulmonary fibrosis. Chest 2003; 124: 548–553.

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42. Tsantes AE, Tassiopoulos ST, Papadhimitriou SI, Bonovas S, Poulakis N, Vlachou A, Filioussi K, Loukopoulos D. Theophylline treatment may adversely affect the anoxia-induced erythropoietic response without suppressing erythropoietin production. European Journal of Clinical Pharmacology 2003; 59: 379–383.

43. Tsantes A, Papadhimitriou SI, Tassiopoulos S, Bonovas S, Paterakis G, Meletis J,

Loukopoulos D. Red cell macrocytosis in hypoxemic patients with chronic obstructive pulmonary disease. Respiratory Medicine 2004; 98: 1117–1123.

44. Tsantes AE, Nikolopoulos GK, Bagos PG, Bonovas S, Kopterides P, Vaiopoulos G.

The effect of the plasminogen activator inhibitor-1 4G/5G polymorphism on the thrombotic risk. Thrombosis Research 2008; 122: 736–742.

45. Tsantes AE, Mantzios G, Giannopoulou V, Tsirigotis P, Bonovas S, Rapti E, Mygiaki E,

Kartasis Z, Sitaras NM, Dervenoulas J, Travlou A. Monitoring aspirin treatment in patients with thrombocytosis: Comparison of the platelet function analyzer (PFA)-100 with optical aggregometry. Thrombosis Research 2008; 123: 100–107.

46. Kani C, Papanikolaou K, Pehlivanidis A, Bonovas S, Papadopoulou-Daifoti Z.

Inhibidores de la colinesterasa y memantina en la enfermedad de Alzheimer: revision sistematica y metaanalisis de ensayos clinicos controlados aleatorizados. Alzheimer 2009; 42: 32–40.

47. Peponis V, Kyttaris VC, Chalkiadakis SE, Bonovas S, Sitaras NM. Ocular side effects of

anti-rheumatic medications: what a rheumatologist should know. Lupus 2010; 19: 675–682.

48. Buti M, Elefsiniotis I, Jardi R, Vargas V, Rodriguez-Frias F, Schapper M, Bonovas S,

Esteban R. Viral genotype and baseline load predict the response to adefovir treatment in lamivudine-resistant chronic hepatitis B patients. Journal of Hepatology 2007; 47: 366-72.

49. Pervanidou D, Horefti E, Patrinos S, Lytras T, Triantafillou E, Mentis A, Bonovas S,

Panagiotopoulos T. Spotlight on measles 2010: Ongoing measles outbreak in Greece, January–July 2010. Eurosurveillance 2010; 15: pii=19629.

50. Athanasiou M, Lytras T, Spala G, Triantafyllou E, Gkolfinopoulou K, Theocharopoulos

G, Patrinos S, Danis K, Detsis M, Tsiodras S, Bonovas S, Panagiotopoulos T. Fatal cases associated with pandemic influenza A(H1N1) reported in Greece. PLoS Currents 2010; 2: pii=RRN1194.

51. Danis K, Papa A, Papanikolaou E, Dougas G, Terzaki I, Baka A, Vrioni G, Kapsimali V,

Tsakris A, Kansouzidou A, Tsiodras S, Vakalis N, Bonovas S, Kremastinou J. Ongoing outbreak of West Nile virus infection in humans, Greece, July to August 2011. Eurosurveillance 2011; 16: pii=19951.

52. Danis K, Papa A, Theocharopoulos G, Dougas G, Athanasiou M, Detsis M, Baka A,

Lytras T, Mellou K, Bonovas S, Panagiotopoulos T. Outbreak of West Nile virus infection in Greece, 2010. Emerging Infectious Diseases 2011; 17: 1868-1872.

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53. ECDC working group on influenza A(H1N1)v (including Bonovas S). Preliminary analysis of influenza A(H1N1)v individual and aggregated case reports from EU and EFTA countries. Eurosurveillance 2009; 14: pii=19238.

54. Devaux I, Kreidl P, Penttinen P, Salminen M, Zucs P, Ammon A; ECDC Influenza

Surveillance Group; National Coordinators for Influenza Surveillance (including Bonovas S). Initial surveillance of 2009 influenza A(H1N1) pandemic in the European Union and European Economic Area, April–September 2009. Eurosurveillance 2010; 15: pii=19740.

55. Amato-Gauci A, Zucs P, Snacken R, Ciancio B, Lopez V, Broberg E, Penttinen P, Nicoll

A; European Influenza Surveillance Network (including Bonovas S). Surveillance trends of the 2009 influenza A(H1N1) pandemic in Europe. Eurosurveillance 2011; 16: pii=19903.

56. Bonovas S, Nikolopoulos G, Sitaras NM. Efficacy and safety of more intensive lowering

of LDL cholesterol [letter]. Lancet 2011; 377: 715–715. 57. Bonovas S, Nikolopoulos G, Sitaras NM. Commentary on pravastatin and cancer: need

for individual patient data meta-analyses [letter]. Pharmacoepidemiology and Drug Safety 2010; 19: 203–204.

58. Bonovas S, Sitaras NM. Statins and cancer risk: a confounded association [letter].

Gastroenterology 2009; 137: 740–740. 59. Bonovas S, Sitaras NM. Statins and pancreatic cancer: Are all statins the same? Response

[letter]. American Journal of Gastroenterology 2009; 104: 525–525. 60. Bonovas S, Filioussi K, Tsavaris N, Sitaras NM. A call for clinical trials: lipophilic statins

may prove effective in treatment and prevention of particular breast cancer subtypes – Reply [letter]. Journal of Clinical Oncology 2006; 24: 2127–2128.

61. Bonovas S, Filioussi K, Tsavaris N, Sitaras NM. Lipophilic statins merit additional study

for breast cancer chemoprevention – Reply [letter]. Journal of Clinical Oncology 2006; 24: 2129–2129.

62. Bonovas S, Filioussi K, Tsavaris N, Sitaras NM. Statins and breast cancer prevention:

time for randomized controlled trials – Reply [letter]. Journal of Clinical Oncology 2006; 24: 2130–2131.

63. Nikolopoulos G, Bonovas S. The media: a public health partner or an unintentional

enemy? [letter]. Public Health 2010; 124: 360–361.