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Supplementary Table S1. All miRNAs detected in the lipid fractions of tMBM and pMBM
microRNA ID Total reads
P-value (pMBM v. tMBM)
FDR step up (pMBM v. tMBM)
Ratio (pMBM v. tMBM)
Fold change (pMBM v. tMBM)
LSMean (pMBM v. tMBM)
hsa-miR-4470 3.24E+02 1.50E-08 4.31E-06 6.75E+01 6.75E+01 1.67E+03hsa-miR-4687-3p 1.52E+04 1.85E-08 4.31E-06 2.82E-01 -3.54E+00 3.03E+03hsa-miR-1260a 7.92E+04 5.96E-08 9.25E-06 4.75E-01 -2.10E+00 2.49E+04hsa-miR-1260b 8.54E+04 1.82E-07 1.70E-05 4.98E-01 -2.01E+00 2.81E+04hsa-miR-378a-3p 7.05E+04 1.53E-07 1.70E-05 5.09E-01 -1.97E+00 2.20E+04hsa-miR-378g 5.73E+04 4.32E-07 3.35E-05 4.76E-01 -2.10E+00 1.67E+04hsa-miR-378c 6.13E+04 8.06E-07 5.36E-05 5.31E-01 -1.88E+00 2.00E+04hsa-miR-4474-5p 2.46E+02 1.15E-06 5.94E-05 3.33E+01 3.33E+01 1.25E+03hsa-miR-6763-3p 2.56E+02 1.03E-06 5.94E-05 4.56E-01 -2.19E+00 9.33E+01hsa-miR-5585-5p 1.93E+02 1.54E-06 7.16E-05 5.89E-01 -1.70E+00 1.11E+02hsa-miR-1200 1.31E+02 8.01E-06 3.39E-04 6.10E-01 -1.64E+00 8.64E+01hsa-miR-4783-5p 1.55E+02 8.88E-06 3.44E-04 5.02E-01 -1.99E+00 9.13E+01hsa-miR-6772-3p 8.70E+02 1.23E-05 4.39E-04 4.97E+00 4.97E+00 2.28E+03hsa-miR-187-5p 2.45E+02 1.81E-05 5.25E-04 5.63E-01 -1.78E+00 1.61E+02hsa-miR-6510-5p 2.08E+02 1.78E-05 5.25E-04 5.02E-01 -1.99E+00 1.13E+02hsa-miR-7852-3p 3.43E+02 1.71E-05 5.25E-04 2.26E+01 2.26E+01 1.73E+03hsa-miR-4302 2.67E+02 2.13E-05 5.71E-04 4.74E-01 -2.11E+00 1.02E+02hsa-miR-92a-3p 5.15E+03 2.21E-05 5.71E-04 3.02E+00 3.02E+00 1.05E+04hsa-miR-296-3p 4.06E+02 2.67E-05 6.53E-04 3.91E-01 -2.56E+00 9.60E+01hsa-miR-5688 1.30E+02 2.90E-05 6.73E-04 1.13E+00 1.13E+00 1.56E+02hsa-miR-500a-5p 6.38E+02 3.52E-05 7.80E-04 3.24E-01 -3.09E+00 1.94E+02hsa-miR-183-5p 3.02E+03 4.26E-05 9.00E-04 3.48E+00 3.48E+00 6.76E+03hsa-miR-2276-3p 2.01E+03 4.54E-05 9.17E-04 4.26E+00 4.26E+00 4.45E+03hsa-miR-6748-3p 1.94E+02 9.30E-05 1.80E-03 4.59E-01 -2.18E+00 1.08E+02hsa-miR-4684-3p 2.20E+02 9.90E-05 1.84E-03 5.43E-01 -1.84E+00 1.40E+02hsa-miR-20b-3p 1.76E+02 1.30E-04 2.32E-03 1.79E+01 1.79E+01 6.74E+02hsa-miR-134-3p 1.70E+03 1.71E-04 2.94E-03 5.42E+01 5.42E+01 7.33E+03hsa-miR-3928-5p 1.69E+02 1.98E-04 3.18E-03 6.39E-01 -1.57E+00 1.28E+02hsa-miR-6757-5p 2.04E+03 1.98E-04 3.18E-03 2.05E+00 2.05E+00 2.69E+03hsa-miR-127-3p 2.32E+02 2.15E-04 3.33E-03 5.04E-01 -1.98E+00 1.21E+02hsa-miR-542-3p 5.04E+02 2.62E-04 3.93E-03 6.31E-01 -1.59E+00 3.24E+02hsa-miR-369-3p 1.74E+03 2.81E-04 3.97E-03 2.54E-01 -3.94E+00 4.45E+02hsa-miR-7975 2.01E+04 2.77E-04 3.97E-03 5.94E-01 -1.68E+00 7.27E+03hsa-miR-3615 1.71E+02 3.12E-04 4.27E-03 7.80E-01 -1.28E+00 1.45E+02hsa-miR-4418 2.04E+02 4.33E-04 5.75E-03 5.02E-01 -1.99E+00 1.35E+02hsa-miR-4712-5p 1.52E+02 5.53E-04 6.96E-03 9.70E-01 -1.03E+00 1.80E+02hsa-miR-6729-3p 1.39E+02 5.54E-04 6.96E-03 1.30E+00 1.30E+00 1.58E+02hsa-miR-452-5p 1.55E+02 6.38E-04 7.81E-03 8.21E-01 -1.22E+00 1.23E+02hsa-miR-1909-3p 1.84E+02 6.82E-04 8.13E-03 7.95E-01 -1.26E+00 1.40E+02hsa-miR-6750-3p 4.74E+02 7.40E-04 8.61E-03 4.09E-01 -2.44E+00 1.77E+02hsa-miR-6727-5p 1.49E+02 9.46E-04 1.07E-02 1.01E+00 1.01E+00 1.53E+02microRNA ID Total P-value FDR step Ratio (pMBM Fold change LSMean (pMBM
reads (pMBM v. tMBM)
up (pMBM v. tMBM) v. tMBM) (pMBM v.
tMBM) v. tMBM)
hsa-miR-1193 2.34E+03 1.14E-03 1.20E-02 2.01E+00 2.01E+00 3.22E+03hsa-miR-5196-3p 7.66E+04 1.09E-03 1.20E-02 6.67E-01 -1.50E+00 2.98E+04hsa-miR-6751-3p 1.89E+02 1.14E-03 1.20E-02 9.30E-01 -1.08E+00 2.39E+02hsa-miR-3074-5p 8.97E+03 1.29E-03 1.31E-02 3.25E+00 3.25E+00 1.59E+04hsa-miR-7107-5p 2.47E+02 1.29E-03 1.31E-02 7.80E-01 -1.28E+00 1.76E+02hsa-miR-1208 3.24E+02 1.43E-03 1.41E-02 4.88E-01 -2.05E+00 1.90E+02hsa-miR-6722-3p 3.27E+02 1.47E-03 1.43E-02 5.63E-01 -1.78E+00 1.97E+02hsa-miR-101-3p 3.41E+02 1.54E-03 1.47E-02 7.59E-01 -1.32E+00 2.34E+02hsa-miR-19b-3p 3.30E+02 1.59E-03 1.48E-02 9.62E-01 -1.04E+00 2.89E+02hsa-let-7a-5p 6.20E+03 1.68E-03 1.53E-02 2.43E+00 2.43E+00 8.91E+03hsa-miR-4688 3.00E+02 1.74E-03 1.55E-02 8.05E-01 -1.24E+00 2.09E+02hsa-miR-3656 4.30E+02 1.87E-03 1.61E-02 7.64E-01 -1.31E+00 3.07E+02hsa-miR-4283 2.55E+02 1.87E-03 1.61E-02 7.08E-01 -1.41E+00 1.46E+02hsa-miR-1237-3p 1.47E+02 1.97E-03 1.64E-02 8.55E-01 -1.17E+00 1.15E+02hsa-miR-6815-5p 4.41E+02 1.94E-03 1.64E-02 8.64E-01 -1.16E+00 3.28E+02hsa-miR-1249-3p 1.87E+02 2.03E-03 1.66E-02 1.04E+00 1.04E+00 1.76E+02hsa-miR-10a-5p 2.76E+03 2.37E-03 1.81E-02 1.75E+00 1.75E+00 3.20E+03hsa-miR-203a-3p 9.53E+02 2.34E-03 1.81E-02 3.48E+00 3.48E+00 2.50E+03hsa-miR-203b-5p 9.53E+02 2.34E-03 1.81E-02 3.48E+00 3.48E+00 2.50E+03hsa-miR-887-3p 3.19E+02 2.37E-03 1.81E-02 6.62E-01 -1.51E+00 1.86E+02hsa-miR-4651 3.03E+02 2.44E-03 1.83E-02 3.54E-01 -2.83E+00 1.02E+02hsa-miR-1273f 3.24E+02 2.55E-03 1.88E-02 7.79E-01 -1.28E+00 2.44E+02hsa-miR-150-5p 5.20E+02 2.68E-03 1.88E-02 4.23E-01 -2.36E+00 2.63E+02hsa-miR-6865-5p 1.44E+04 2.65E-03 1.88E-02 6.20E-01 -1.61E+00 5.29E+03hsa-miR-7157-5p 1.25E+02 2.71E-03 1.88E-02 1.18E+00 1.18E+00 1.62E+02hsa-miR-8080 9.41E+02 2.69E-03 1.88E-02 1.09E+00 1.09E+00 6.13E+02hsa-miR-491-3p 1.19E+03 3.12E-03 2.10E-02 1.69E+01 1.69E+01 5.04E+03hsa-miR-6815-3p 2.49E+02 3.07E-03 2.10E-02 1.10E+00 1.10E+00 1.87E+02hsa-miR-6741-5p 1.27E+02 3.22E-03 2.14E-02 1.06E+00 1.06E+00 9.94E+01hsa-miR-4664-3p 1.73E+02 3.43E-03 2.22E-02 8.30E-01 -1.21E+00 1.47E+02hsa-miR-4723-5p 2.54E+02 3.41E-03 2.22E-02 1.13E+00 1.13E+00 2.21E+02hsa-miR-6738-5p 1.45E+02 3.67E-03 2.34E-02 1.24E+00 1.24E+00 1.47E+02hsa-miR-6863 1.72E+02 3.77E-03 2.37E-02 7.31E-01 -1.37E+00 1.17E+02hsa-miR-510-3p 1.94E+02 3.89E-03 2.41E-02 9.32E-01 -1.07E+00 1.68E+02hsa-miR-3972 9.60E+01 4.21E-03 2.51E-02 1.27E+00 1.27E+00 1.11E+02hsa-miR-4508 4.74E+02 4.18E-03 2.51E-02 6.72E-01 -1.49E+00 3.24E+02hsa-miR-6862-3p 9.70E+01 4.14E-03 2.51E-02 1.59E+00 1.59E+00 1.60E+02hsa-miR-193a-5p 3.16E+02 4.45E-03 2.56E-02 1.00E+00 1.00E+00 2.29E+02hsa-miR-345-3p 2.58E+02 4.53E-03 2.56E-02 6.24E-01 -1.60E+00 1.30E+02hsa-miR-378i 1.58E+04 4.56E-03 2.56E-02 6.26E-01 -1.60E+00 5.64E+03hsa-miR-3934-5p 8.11E+02 4.47E-03 2.56E-02 8.92E+00 8.92E+00 2.50E+03hsa-miR-5684 1.14E+02 4.37E-03 2.56E-02 1.39E+00 1.39E+00 1.41E+02hsa-miR-221-3p 1.82E+02 5.23E-03 2.87E-02 9.83E-01 -1.02E+00 1.44E+02microRNA ID Total
readsP-value (pMBM v.
FDR step up (pMBM
Ratio (pMBM v. tMBM)
Fold change (pMBM v.
LSMean (pMBM v. tMBM)
tMBM) v. tMBM) tMBM)hsa-miR-6777-5p 2.73E+02 5.25E-03 2.87E-02 1.02E+00 1.02E+00 2.09E+02hsa-miR-6743-5p 2.78E+02 5.47E-03 2.96E-02 8.99E-01 -1.11E+00 2.04E+02hsa-miR-1231 1.17E+02 5.69E-03 3.04E-02 9.62E-01 -1.04E+00 1.09E+02hsa-miR-4784 6.56E+03 5.78E-03 3.06E-02 2.07E+00 2.07E+00 6.31E+03hsa-miR-1273g-3p 1.96E+02 6.03E-03 3.14E-02 1.07E+00 1.07E+00 1.99E+02hsa-miR-6812-3p 3.60E+02 6.13E-03 3.14E-02 9.94E-01 -1.01E+00 2.41E+02hsa-miR-6893-3p 1.67E+02 6.15E-03 3.14E-02 9.83E-01 -1.02E+00 1.50E+02hsa-miR-6874-5p 1.38E+02 6.22E-03 3.14E-02 1.03E+00 1.03E+00 1.06E+02hsa-let-7b-5p 4.29E+03 6.39E-03 3.16E-02 2.42E+00 2.42E+00 6.64E+03hsa-miR-378f 3.97E+02 6.34E-03 3.16E-02 7.09E-01 -1.41E+00 1.46E+02hsa-miR-4700-3p 1.26E+02 6.92E-03 3.32E-02 1.32E+00 1.32E+00 1.02E+02hsa-miR-4726-3p 1.49E+02 6.87E-03 3.32E-02 8.92E-01 -1.12E+00 1.12E+02hsa-miR-7158-5p 3.12E+02 7.01E-03 3.32E-02 6.95E-01 -1.44E+00 1.98E+02hsa-miR-8079 1.75E+02 6.97E-03 3.32E-02 5.53E-01 -1.81E+00 1.48E+02hsa-miR-5787 1.16E+03 7.14E-03 3.35E-02 2.11E+00 2.11E+00 1.72E+03hsa-miR-378h 8.75E+04 7.29E-03 3.36E-02 8.03E-01 -1.25E+00 3.44E+04hsa-miR-4668-5p 3.16E+03 7.29E-03 3.36E-02 3.02E-01 -3.31E+00 1.35E+03hsa-miR-4529-3p 3.88E+02 7.96E-03 3.63E-02 7.26E-01 -1.38E+00 2.35E+02hsa-miR-6892-3p 1.63E+02 8.32E-03 3.75E-02 1.16E+00 1.16E+00 1.30E+02hsa-miR-639 2.67E+03 8.62E-03 3.85E-02 2.21E-01 -4.53E+00 6.99E+02hsa-miR-484 1.95E+02 1.03E-02 4.56E-02 1.07E+00 1.07E+00 1.74E+02hsa-miR-29c-3p 2.04E+02 1.04E-02 4.57E-02 9.73E-01 -1.03E+00 2.01E+02hsa-miR-4745-3p 1.53E+02 1.06E-02 4.60E-02 1.25E+00 1.25E+00 1.43E+02hsa-miR-3655 2.54E+03 1.07E-02 4.63E-02 2.97E-01 -3.37E+00 8.69E+02hsa-miR-615-5p 3.20E+02 1.13E-02 4.83E-02 1.28E+00 1.28E+00 2.80E+02hsa-miR-5100 7.58E+03 1.16E-02 4.90E-02 1.53E+00 1.53E+00 1.12E+04hsa-miR-671-3p 2.16E+02 1.17E-02 4.90E-02 9.30E-01 -1.08E+00 1.59E+02hsa-miR-4787-3p 1.85E+02 1.20E-02 4.95E-02 1.63E+00 1.63E+00 2.14E+02hsa-miR-6513-5p 5.27E+02 1.20E-02 4.95E-02 6.19E-01 -1.62E+00 3.35E+02hsa-miR-4304 1.88E+02 1.24E-02 5.05E-02 8.43E-01 -1.19E+00 1.80E+02hsa-miR-4680-3p 4.79E+02 1.27E-02 5.10E-02 4.97E-01 -2.01E+00 3.83E+02hsa-miR-6126 6.41E+02 1.27E-02 5.10E-02 1.80E+00 1.80E+00 9.20E+02hsa-miR-6730-3p 1.34E+02 1.31E-02 5.19E-02 1.00E+00 1.00E+00 1.39E+02hsa-let-7d-3p 6.39E+02 1.36E-02 5.37E-02 7.62E-01 -1.31E+00 4.71E+02hsa-miR-5703 1.67E+02 1.44E-02 5.64E-02 9.65E-01 -1.04E+00 1.15E+02hsa-miR-650 5.84E+03 1.51E-02 5.84E-02 3.70E-01 -2.70E+00 1.37E+03hsa-miR-147a 5.49E+03 1.53E-02 5.87E-02 2.07E+00 2.07E+00 4.96E+03hsa-miR-654-5p 3.20E+02 1.54E-02 5.87E-02 9.41E-01 -1.06E+00 2.33E+02hsa-let-7f-5p 4.50E+03 1.61E-02 6.04E-02 2.55E+00 2.55E+00 7.25E+03hsa-miR-15a-5p 6.35E+03 1.61E-02 6.04E-02 3.60E-01 -2.77E+00 3.29E+03hsa-miR-151a-5p 2.84E+02 1.66E-02 6.12E-02 8.67E-01 -1.15E+00 2.12E+02hsa-miR-6772-5p 1.97E+02 1.65E-02 6.12E-02 1.17E+00 1.17E+00 1.82E+02hsa-miR-27a-3p 3.14E+02 1.75E-02 6.39E-02 1.12E+00 1.12E+00 3.22E+02
microRNA ID Total reads
P-value (pMBM v. tMBM)
FDR step up (pMBM v. tMBM)
Ratio (pMBM v. tMBM)
Fold change (pMBM v. tMBM)
LSMean (pMBM v. tMBM)
hsa-miR-208b-3p 3.16E+03 1.76E-02 6.41E-02 3.31E-01 -3.02E+00 1.49E+03hsa-miR-1272 9.10E+01 1.79E-02 6.47E-02 1.02E+00 1.02E+00 1.16E+02hsa-miR-1913 4.64E+03 1.84E-02 6.58E-02 3.23E-01 -3.10E+00 9.08E+02hsa-miR-7106-5p 1.44E+02 1.85E-02 6.58E-02 1.95E+00 1.95E+00 3.06E+02hsa-miR-4695-3p 1.76E+04 1.89E-02 6.66E-02 7.61E-01 -1.31E+00 7.91E+03hsa-miR-582-5p 4.41E+02 2.05E-02 7.15E-02 6.03E-01 -1.66E+00 2.32E+02hsa-miR-4800-3p 3.50E+02 2.09E-02 7.24E-02 1.13E+00 1.13E+00 3.68E+02hsa-miR-1343-5p 3.09E+02 2.10E-02 7.25E-02 9.01E-01 -1.11E+00 2.49E+02hsa-miR-1233-5p 1.12E+02 2.19E-02 7.33E-02 2.26E+00 2.26E+00 1.70E+02hsa-miR-1307-3p 4.41E+02 2.16E-02 7.33E-02 9.65E-01 -1.04E+00 3.98E+02hsa-miR-4502 4.08E+02 2.16E-02 7.33E-02 5.69E-01 -1.76E+00 1.95E+02hsa-miR-7704 2.68E+03 2.19E-02 7.33E-02 1.25E+00 1.25E+00 3.72E+03hsa-miR-7161-3p 1.42E+02 2.24E-02 7.43E-02 1.27E+00 1.27E+00 1.22E+02hsa-miR-320a 8.80E+03 2.28E-02 7.51E-02 2.75E+00 2.75E+00 1.20E+04hsa-miR-1228-3p 1.23E+02 2.44E-02 7.89E-02 1.31E+00 1.31E+00 1.24E+02hsa-miR-3141 8.53E+02 2.41E-02 7.89E-02 1.76E+00 1.76E+00 1.15E+03hsa-miR-4684-5p 1.08E+02 2.44E-02 7.89E-02 1.49E+00 1.49E+00 1.42E+02hsa-miR-6836-5p 1.89E+02 2.55E-02 8.18E-02 1.76E+00 1.76E+00 2.20E+02hsa-miR-149-3p 1.12E+02 2.62E-02 8.30E-02 1.11E+00 1.11E+00 1.14E+02hsa-miR-888-3p 1.12E+02 2.62E-02 8.30E-02 1.19E+00 1.19E+00 1.22E+02hsa-miR-1181 4.83E+02 2.70E-02 8.44E-02 2.23E+00 2.23E+00 6.84E+02hsa-miR-4261 2.48E+02 2.69E-02 8.44E-02 8.70E-01 -1.15E+00 1.71E+02hsa-miR-30d-5p 6.62E+03 2.75E-02 8.53E-02 6.33E-01 -1.58E+00 4.09E+03hsa-miR-6780b-5p 1.64E+02 2.82E-02 8.67E-02 1.36E+00 1.36E+00 2.47E+02hsa-miR-4664-5p 2.83E+03 2.88E-02 8.82E-02 3.69E-01 -2.71E+00 6.59E+02hsa-miR-3180-5p 1.71E+02 2.93E-02 8.90E-02 1.22E+00 1.22E+00 2.15E+02hsa-miR-4739 3.85E+02 2.95E-02 8.90E-02 2.12E+00 2.12E+00 5.53E+02hsa-miR-6786-5p 2.02E+02 2.97E-02 8.92E-02 1.43E+00 1.43E+00 2.47E+02hsa-miR-3944-5p 7.25E+02 3.04E-02 9.06E-02 4.88E-01 -2.05E+00 3.57E+02hsa-miR-6850-5p 1.37E+02 3.10E-02 9.19E-02 1.67E+00 1.67E+00 1.74E+02hsa-let-7g-3p 6.17E+03 3.16E-02 9.20E-02 5.96E-01 -1.68E+00 2.72E+03hsa-miR-1180-3p 2.23E+02 3.16E-02 9.20E-02 1.15E+00 1.15E+00 2.11E+02hsa-miR-4321 1.93E+02 3.14E-02 9.20E-02 1.07E+00 1.07E+00 1.81E+02hsa-miR-4513 1.07E+02 3.22E-02 9.29E-02 1.53E+00 1.53E+00 1.33E+02hsa-miR-3178 1.94E+02 3.24E-02 9.30E-02 2.58E+00 2.58E+00 2.68E+02hsa-miR-23a-5p 1.10E+02 3.26E-02 9.30E-02 1.68E+00 1.68E+00 1.62E+02hsa-miR-3692-5p 8.33E+02 3.31E-02 9.39E-02 1.85E+00 1.85E+00 1.42E+03hsa-miR-4660 2.19E+02 3.49E-02 9.82E-02 1.21E+00 1.21E+00 2.03E+02hsa-miR-6071 9.40E+01 3.57E-02 1.00E-01 1.94E+00 1.94E+00 1.41E+02hsa-miR-361-3p 2.77E+02 3.60E-02 1.00E-01 1.38E+00 1.38E+00 2.92E+02hsa-miR-425-5p 2.76E+02 3.71E-02 1.03E-01 2.16E+00 2.16E+00 4.41E+02hsa-miR-4299 2.38E+02 3.93E-02 1.08E-01 1.32E+00 1.32E+00 2.15E+02hsa-miR-1303 8.14E+02 4.10E-02 1.09E-01 5.69E-01 -1.76E+00 5.06E+02
microRNA ID Total reads
P-value (pMBM v. tMBM)
FDR step up (pMBM v. tMBM)
Ratio (pMBM v. tMBM)
Fold change (pMBM v. tMBM)
LSMean (pMBM v. tMBM)
hsa-miR-24-2-5p 2.70E+02 4.08E-02 1.09E-01 6.46E+00 6.46E+00 8.37E+02hsa-miR-3939 1.99E+02 4.07E-02 1.09E-01 8.14E-01 -1.23E+00 1.80E+02hsa-miR-4492 7.46E+02 4.09E-02 1.09E-01 1.07E+00 1.07E+00 7.58E+02hsa-miR-7110-5p 2.53E+02 4.04E-02 1.09E-01 1.44E+00 1.44E+00 2.06E+02hsa-miR-8077 5.12E+02 4.06E-02 1.09E-01 3.13E+00 3.13E+00 9.06E+02hsa-miR-6826-5p 1.75E+02 4.30E-02 1.14E-01 1.27E+00 1.27E+00 2.49E+02hsa-miR-181a-5p 2.24E+03 4.36E-02 1.14E-01 1.83E+00 1.83E+00 2.96E+03hsa-miR-6511a-5p 1.66E+02 4.49E-02 1.17E-01 1.59E+00 1.59E+00 2.34E+02hsa-miR-125b-5p 5.04E+02 4.67E-02 1.21E-01 9.16E-01 -1.09E+00 3.43E+02hsa-miR-885-5p 2.31E+02 4.74E-02 1.22E-01 6.88E-01 -1.45E+00 1.25E+02hsa-miR-6796-3p 1.55E+02 4.83E-02 1.24E-01 1.64E+00 1.64E+00 1.87E+02hsa-miR-1180-5p 3.05E+02 4.98E-02 1.26E-01 1.34E+00 1.34E+00 3.13E+02hsa-miR-4270 1.33E+02 4.96E-02 1.26E-01 1.69E+00 1.69E+00 1.24E+02hsa-miR-6768-5p 1.94E+02 4.95E-02 1.26E-01 1.63E+00 1.63E+00 2.47E+02hsa-miR-3195 8.87E+02 5.06E-02 1.27E-01 8.92E-01 -1.12E+00 6.03E+02hsa-miR-596 1.53E+02 5.21E-02 1.30E-01 1.22E+00 1.22E+00 1.63E+02hsa-miR-4267 1.36E+02 5.24E-02 1.30E-01 1.08E+00 1.08E+00 1.88E+02hsa-miR-4652-3p 2.19E+02 5.37E-02 1.33E-01 7.57E+00 7.57E+00 6.74E+02hsa-miR-6822-5p 1.49E+02 5.44E-02 1.34E-01 1.41E+00 1.41E+00 1.60E+02hsa-miR-6088 1.82E+02 5.50E-02 1.35E-01 1.43E+00 1.43E+00 2.23E+02hsa-let-7g-5p 8.08E+03 5.71E-02 1.38E-01 1.86E+00 1.86E+00 1.12E+04hsa-miR-4674 2.09E+02 5.70E-02 1.38E-01 1.70E+00 1.70E+00 2.28E+02hsa-miR-183-3p 8.83E+02 5.74E-02 1.38E-01 1.93E+00 1.93E+00 1.36E+03hsa-miR-339-3p 2.15E+02 5.77E-02 1.38E-01 9.86E-01 -1.01E+00 2.37E+02hsa-miR-370-3p 1.41E+03 5.84E-02 1.39E-01 1.28E+00 1.28E+00 1.99E+03hsa-miR-6870-5p 1.88E+02 5.91E-02 1.40E-01 1.06E+00 1.06E+00 1.62E+02hsa-miR-4783-3p 2.48E+03 6.09E-02 1.44E-01 1.80E+00 1.80E+00 3.01E+03hsa-miR-29a-3p 9.81E+02 6.21E-02 1.45E-01 1.20E+00 1.20E+00 9.85E+02hsa-miR-4497 1.29E+03 6.18E-02 1.45E-01 1.48E+00 1.48E+00 1.67E+03hsa-miR-375 2.15E+04 6.30E-02 1.45E-01 1.61E+00 1.61E+00 2.68E+04hsa-miR-4763-3p 1.31E+02 6.29E-02 1.45E-01 1.83E+01 1.83E+01 6.13E+02hsa-miR-4781-5p 9.90E+01 6.30E-02 1.45E-01 1.76E+00 1.76E+00 1.33E+02hsa-miR-1237-5p 8.32E+02 6.49E-02 1.49E-01 1.51E+00 1.51E+00 7.68E+02hsa-miR-6769a-5p 3.04E+02 6.55E-02 1.49E-01 4.57E+00 4.57E+00 6.95E+02hsa-miR-4665-5p 1.12E+02 6.61E-02 1.50E-01 2.16E+00 2.16E+00 2.15E+02hsa-miR-148a-5p 1.28E+02 6.70E-02 1.51E-01 2.94E+00 2.94E+00 2.41E+02hsa-miR-4258 2.00E+02 6.78E-02 1.52E-01 2.33E+00 2.33E+00 2.22E+02hsa-miR-6805-3p 4.65E+02 6.81E-02 1.52E-01 1.18E+00 1.18E+00 4.58E+02hsa-miR-1276 1.67E+02 6.88E-02 1.53E-01 1.03E+00 1.03E+00 2.66E+02hsa-miR-200c-3p 4.49E+03 6.92E-02 1.53E-01 1.83E+00 1.83E+00 5.73E+03hsa-miR-584-3p 1.46E+02 7.15E-02 1.58E-01 1.41E+00 1.41E+00 2.09E+02hsa-miR-125a-3p 1.65E+02 7.19E-02 1.58E-01 1.99E+00 1.99E+00 2.30E+02hsa-miR-5010-3p 2.36E+03 7.22E-02 1.58E-01 1.87E+00 1.87E+00 2.97E+03
microRNA ID Total reads
P-value (pMBM v. tMBM)
FDR step up (pMBM v. tMBM)
Ratio (pMBM v. tMBM)
Fold change (pMBM v. tMBM)
LSMean (pMBM v. tMBM)
hsa-miR-3665 1.33E+02 7.34E-02 1.59E-01 2.16E+00 2.16E+00 1.83E+02hsa-miR-6735-3p 2.69E+02 7.35E-02 1.59E-01 1.38E+00 1.38E+00 2.08E+02hsa-miR-4690-3p 1.88E+02 7.39E-02 1.59E-01 1.31E+00 1.31E+00 2.44E+02hsa-miR-26b-5p 3.08E+02 7.44E-02 1.59E-01 2.13E+00 2.13E+00 4.40E+02hsa-miR-1539 3.76E+02 7.59E-02 1.62E-01 8.56E-01 -1.17E+00 3.77E+02hsa-miR-320b 4.13E+02 7.82E-02 1.64E-01 6.85E+00 6.85E+00 7.40E+02hsa-miR-378a-5p 2.16E+05 7.84E-02 1.64E-01 8.00E-01 -1.25E+00 8.71E+04hsa-miR-4281 2.31E+02 7.80E-02 1.64E-01 1.10E+00 1.10E+00 1.98E+02hsa-miR-629-5p 1.56E+02 7.85E-02 1.64E-01 2.34E+00 2.34E+00 2.29E+02hsa-miR-638 1.67E+02 8.01E-02 1.67E-01 2.35E+00 2.35E+00 2.15E+02hsa-miR-30e-5p 4.82E+02 8.06E-02 1.67E-01 8.53E-01 -1.17E+00 3.98E+02hsa-miR-1225-3p 1.46E+02 8.15E-02 1.68E-01 1.72E+00 1.72E+00 1.45E+02hsa-miR-92b-3p 2.65E+02 8.24E-02 1.69E-01 1.01E+00 1.01E+00 3.42E+02hsa-miR-4462 1.73E+02 8.74E-02 1.79E-01 1.09E+00 1.09E+00 1.53E+02hsa-miR-5001-5p 9.80E+01 8.86E-02 1.81E-01 1.54E+00 1.54E+00 1.33E+02hsa-miR-1301-5p 1.53E+02 9.03E-02 1.83E-01 2.77E+00 2.77E+00 3.08E+02hsa-miR-3127-5p 1.71E+02 9.03E-02 1.83E-01 1.56E+00 1.56E+00 2.77E+02hsa-miR-4802-5p 3.38E+02 9.37E-02 1.89E-01 6.87E-01 -1.46E+00 2.31E+02hsa-miR-4781-3p 1.74E+03 9.45E-02 1.89E-01 6.09E+00 6.09E+00 5.01E+03hsa-miR-6087 7.05E+02 9.70E-02 1.94E-01 1.74E+00 1.74E+00 9.30E+02hsa-miR-4767 1.88E+02 9.74E-02 1.94E-01 1.83E+00 1.83E+00 2.22E+02hsa-miR-7114-5p 2.83E+02 9.81E-02 1.94E-01 1.32E+00 1.32E+00 3.77E+02hsa-miR-663b 1.57E+03 9.95E-02 1.96E-01 1.51E+00 1.51E+00 1.76E+03hsa-miR-7107-3p 1.59E+02 9.98E-02 1.96E-01 1.18E+01 1.18E+01 7.39E+02hsa-miR-6803-5p 1.84E+02 1.01E-01 1.97E-01 1.98E+00 1.98E+00 3.36E+02hsa-miR-93-5p 3.82E+03 1.02E-01 1.99E-01 1.70E+00 1.70E+00 5.09E+03hsa-miR-5196-5p 1.04E+03 1.03E-01 1.99E-01 8.92E-01 -1.12E+00 5.36E+02hsa-miR-1289 9.10E+01 1.07E-01 2.05E-01 2.44E+00 2.44E+00 1.86E+02hsa-miR-27b-3p 4.41E+02 1.07E-01 2.05E-01 1.65E+00 1.65E+00 4.74E+02hsa-miR-3975 1.46E+02 1.07E-01 2.05E-01 5.14E+00 5.14E+00 3.25E+02hsa-miR-940 2.97E+02 1.07E-01 2.05E-01 1.35E+00 1.35E+00 3.53E+02hsa-miR-212-5p 3.48E+02 1.08E-01 2.05E-01 1.32E+00 1.32E+00 5.38E+02hsa-miR-432-3p 4.38E+02 1.08E-01 2.05E-01 1.42E+00 1.42E+00 3.69E+02hsa-miR-323a-5p 1.73E+02 1.13E-01 2.13E-01 1.25E+00 1.25E+00 1.49E+02hsa-miR-433-5p 1.26E+02 1.15E-01 2.15E-01 2.04E+00 2.04E+00 1.87E+02hsa-miR-1254 1.79E+02 1.16E-01 2.17E-01 1.39E+00 1.39E+00 1.76E+02hsa-miR-429 1.30E+03 1.19E-01 2.22E-01 1.45E+00 1.45E+00 1.52E+03hsa-miR-4787-5p 1.76E+04 1.21E-01 2.23E-01 7.91E-01 -1.26E+00 8.06E+03hsa-miR-6790-3p 2.87E+02 1.21E-01 2.23E-01 1.84E+00 1.84E+00 4.25E+02hsa-miR-4322 3.01E+02 1.23E-01 2.27E-01 1.71E+00 1.71E+00 3.24E+02hsa-miR-668-3p 8.51E+02 1.26E-01 2.31E-01 8.73E-01 -1.15E+00 7.22E+02hsa-miR-598-5p 2.88E+03 1.29E-01 2.35E-01 7.60E-01 -1.31E+00 1.22E+03hsa-miR-3185 1.39E+02 1.30E-01 2.36E-01 2.07E+00 2.07E+00 2.05E+02
microRNA ID Total reads
P-value (pMBM v. tMBM)
FDR step up (pMBM v. tMBM)
Ratio (pMBM v. tMBM)
Fold change (pMBM v. tMBM)
LSMean (pMBM v. tMBM)
hsa-miR-145-5p 9.60E+01 1.34E-01 2.42E-01 5.89E+00 5.89E+00 3.00E+02hsa-miR-3181 1.18E+03 1.36E-01 2.45E-01 8.82E-01 -1.13E+00 6.57E+02hsa-miR-762 6.05E+02 1.38E-01 2.47E-01 1.38E+00 1.38E+00 6.45E+02hsa-miR-4731-3p 3.78E+02 1.44E-01 2.58E-01 9.91E-01 -1.01E+00 3.34E+02hsa-miR-34b-3p 1.28E+02 1.48E-01 2.63E-01 1.74E+00 1.74E+00 1.87E+02hsa-miR-4449 2.59E+02 1.49E-01 2.64E-01 1.17E+00 1.17E+00 2.47E+02hsa-miR-6737-5p 2.26E+02 1.50E-01 2.66E-01 1.55E+00 1.55E+00 2.43E+02hsa-miR-1263 5.38E+02 1.55E-01 2.71E-01 1.25E+00 1.25E+00 4.74E+02hsa-miR-449b-3p 2.36E+02 1.54E-01 2.71E-01 1.16E+00 1.16E+00 2.70E+02hsa-miR-4792 6.08E+02 1.55E-01 2.71E-01 5.45E-01 -1.84E+00 3.17E+02hsa-miR-4488 1.42E+03 1.56E-01 2.72E-01 1.48E+00 1.48E+00 1.18E+03hsa-miR-1469 7.55E+02 1.60E-01 2.77E-01 1.22E+00 1.22E+00 7.61E+02hsa-miR-26a-5p 4.60E+03 1.61E-01 2.79E-01 1.65E+00 1.65E+00 5.70E+03hsa-miR-4730 1.48E+02 1.66E-01 2.87E-01 1.48E+00 1.48E+00 2.08E+02hsa-miR-125a-5p 4.63E+02 1.68E-01 2.88E-01 1.09E+00 1.09E+00 4.21E+02hsa-miR-132-3p 3.53E+02 1.68E-01 2.88E-01 1.36E+00 1.36E+00 3.15E+02hsa-miR-6856-5p 1.00E+02 1.71E-01 2.91E-01 1.74E+00 1.74E+00 1.17E+02hsa-miR-572 1.74E+02 1.75E-01 2.96E-01 2.17E+00 2.17E+00 2.43E+02hsa-miR-636 3.34E+02 1.75E-01 2.96E-01 1.10E+00 1.10E+00 3.83E+02hsa-miR-6723-5p 2.96E+02 1.78E-01 3.00E-01 1.05E+00 1.05E+00 4.61E+02hsa-miR-1268b 1.24E+02 1.82E-01 3.04E-01 2.09E+00 2.09E+00 1.44E+02hsa-miR-24-3p 2.08E+03 1.82E-01 3.04E-01 2.60E+00 2.60E+00 3.66E+03hsa-miR-6871-3p 8.13E+02 1.83E-01 3.05E-01 7.75E-01 -1.29E+00 5.38E+02hsa-miR-4785 8.55E+02 1.85E-01 3.07E-01 1.08E+00 1.08E+00 7.13E+02hsa-miR-3621 4.82E+02 1.91E-01 3.17E-01 3.38E+00 3.38E+00 1.18E+03hsa-miR-1281 1.59E+02 1.96E-01 3.22E-01 2.58E+00 2.58E+00 3.11E+02hsa-miR-578 4.95E+02 1.96E-01 3.22E-01 1.24E+00 1.24E+00 4.97E+02hsa-miR-2277-3p 1.62E+02 2.05E-01 3.35E-01 1.36E+00 1.36E+00 1.91E+02hsa-miR-5581-3p 3.06E+02 2.05E-01 3.35E-01 1.14E+00 1.14E+00 2.06E+02hsa-miR-3134 2.90E+03 2.07E-01 3.36E-01 1.52E+00 1.52E+00 2.57E+03hsa-miR-508-3p 1.44E+03 2.09E-01 3.39E-01 1.50E+00 1.50E+00 1.25E+03hsa-miR-103a-3p 6.97E+02 2.17E-01 3.40E-01 1.11E+00 1.11E+00 6.63E+02hsa-miR-103b 6.97E+02 2.17E-01 3.40E-01 1.11E+00 1.11E+00 6.63E+02hsa-miR-185-3p 1.53E+02 2.15E-01 3.40E-01 1.86E+00 1.86E+00 2.42E+02hsa-miR-1908-5p 2.36E+02 2.13E-01 3.40E-01 5.28E+00 5.28E+00 5.52E+02hsa-miR-4286 7.24E+02 2.12E-01 3.40E-01 1.01E+00 1.01E+00 4.90E+02hsa-miR-4459 2.34E+02 2.15E-01 3.40E-01 3.52E+00 3.52E+00 5.48E+02hsa-miR-4693-3p 7.08E+02 2.14E-01 3.40E-01 4.96E+00 4.96E+00 1.98E+03hsa-miR-4741 2.99E+02 2.12E-01 3.40E-01 3.16E+00 3.16E+00 5.07E+02hsa-miR-5696 8.50E+01 2.14E-01 3.40E-01 2.02E+00 2.02E+00 1.38E+02hsa-miR-30e-3p 2.08E+02 2.19E-01 3.43E-01 1.85E+00 1.85E+00 3.16E+02hsa-let-7c-5p 8.32E+02 2.28E-01 3.53E-01 3.35E+00 3.35E+00 1.48E+03hsa-miR-1295a 6.65E+01 2.28E-01 3.53E-01 1.29E+00 1.29E+00 7.80E+01
microRNA ID Total reads
P-value (pMBM v. tMBM)
FDR step up (pMBM v. tMBM)
Ratio (pMBM v. tMBM)
Fold change (pMBM v. tMBM)
LSMean (pMBM v. tMBM)
hsa-miR-1295b-5p 6.65E+01 2.28E-01 3.53E-01 1.29E+00 1.29E+00 7.80E+01hsa-miR-197-3p 1.09E+02 2.34E-01 3.61E-01 1.86E+00 1.86E+00 1.43E+02hsa-miR-3190-5p 1.56E+02 2.37E-01 3.65E-01 1.44E+00 1.44E+00 1.61E+02hsa-miR-6820-3p 1.55E+02 2.38E-01 3.65E-01 1.85E+00 1.85E+00 1.47E+02hsa-miR-1292-5p 3.33E+02 2.42E-01 3.71E-01 1.95E+00 1.95E+00 5.53E+02hsa-miR-4540 9.58E+03 2.44E-01 3.72E-01 1.25E+00 1.25E+00 7.70E+03hsa-miR-4634 5.84E+02 2.51E-01 3.81E-01 1.25E+00 1.25E+00 5.97E+02hsa-miR-6769b-5p 9.80E+01 2.56E-01 3.87E-01 2.63E+00 2.63E+00 1.95E+02hsa-miR-1228-5p 1.62E+02 2.64E-01 3.99E-01 2.02E+00 2.02E+00 1.93E+02hsa-miR-3663-5p 2.21E+02 2.68E-01 4.03E-01 1.43E+00 1.43E+00 3.22E+02hsa-miR-3184-5p 2.27E+03 2.71E-01 4.06E-01 1.09E+00 1.09E+00 2.39E+03hsa-miR-4265 2.39E+02 2.75E-01 4.10E-01 2.05E+00 2.05E+00 2.67E+02hsa-miR-503-3p 2.18E+02 2.75E-01 4.10E-01 2.97E+00 2.97E+00 4.05E+02hsa-miR-181b-5p 1.45E+03 2.83E-01 4.20E-01 1.68E+00 1.68E+00 1.84E+03hsa-miR-4298 1.01E+03 2.97E-01 4.40E-01 1.68E+00 1.68E+00 1.37E+03hsa-miR-193b-3p 1.97E+03 3.01E-01 4.44E-01 1.50E+00 1.50E+00 2.87E+03hsa-miR-423-3p 8.69E+02 3.02E-01 4.44E-01 2.76E+00 2.76E+00 1.69E+03hsa-miR-6765-3p 4.08E+03 3.03E-01 4.44E-01 1.32E+00 1.32E+00 4.64E+03hsa-miR-6822-3p 1.27E+02 3.05E-01 4.44E-01 2.10E+00 2.10E+00 2.12E+02hsa-miR-7109-5p 1.95E+02 3.04E-01 4.44E-01 2.43E+00 2.43E+00 3.00E+02hsa-miR-4457 1.98E+02 3.08E-01 4.47E-01 1.56E+00 1.56E+00 2.56E+02hsa-miR-4771 9.60E+01 3.12E-01 4.50E-01 6.45E+00 6.45E+00 3.72E+02hsa-miR-501-5p 3.98E+02 3.12E-01 4.50E-01 1.40E+00 1.40E+00 4.79E+02hsa-miR-6821-5p 6.18E+02 3.11E-01 4.50E-01 9.63E-01 -1.04E+00 5.24E+02hsa-miR-1908-3p 8.00E+02 3.19E-01 4.56E-01 1.16E+00 1.16E+00 8.48E+02hsa-miR-4448 3.01E+02 3.20E-01 4.56E-01 2.20E+00 2.20E+00 4.42E+02hsa-miR-6765-5p 3.43E+03 3.19E-01 4.56E-01 8.25E-01 -1.21E+00 1.95E+03hsa-miR-874-3p 3.93E+02 3.21E-01 4.56E-01 1.50E+00 1.50E+00 4.83E+02hsa-miR-483-5p 1.17E+02 3.24E-01 4.59E-01 2.82E+00 2.82E+00 2.27E+02hsa-miR-1915-3p 3.36E+02 3.33E-01 4.71E-01 1.62E+00 1.62E+00 4.77E+02hsa-miR-3196 5.82E+02 3.34E-01 4.71E-01 1.40E+00 1.40E+00 6.29E+02hsa-miR-1251-3p 3.41E+02 3.40E-01 4.76E-01 7.95E-01 -1.26E+00 2.64E+02hsa-miR-210-3p 1.45E+02 3.39E-01 4.76E-01 1.97E+00 1.97E+00 1.57E+02hsa-miR-4433a-5p 5.65E+01 3.45E-01 4.80E-01 5.51E+00 5.51E+00 1.27E+02hsa-miR-4433b-3p 5.65E+01 3.45E-01 4.80E-01 5.51E+00 5.51E+00 1.27E+02hsa-miR-301b-5p 4.13E+02 3.50E-01 4.85E-01 2.48E+00 2.48E+00 7.66E+02hsa-miR-6724-5p 1.53E+03 3.50E-01 4.85E-01 1.14E+00 1.14E+00 1.26E+03hsa-miR-214-3p 2.54E+02 3.54E-01 4.89E-01 3.78E-01 -2.64E+00 1.04E+02hsa-miR-23a-3p 3.65E+02 3.65E-01 5.01E-01 2.31E+00 2.31E+00 5.27E+02hsa-miR-6789-3p 3.15E+02 3.65E-01 5.01E-01 2.08E+00 2.08E+00 3.64E+02hsa-miR-6782-5p 7.90E+01 3.71E-01 5.08E-01 3.10E+00 3.10E+00 1.48E+02hsa-miR-6804-5p 8.12E+04 3.80E-01 5.18E-01 8.89E-01 -1.13E+00 3.67E+04hsa-miR-4721 9.98E+02 3.98E-01 5.41E-01 1.64E+00 1.64E+00 1.19E+03
microRNA ID Total reads
P-value (pMBM v. tMBM)
FDR step up (pMBM v. tMBM)
Ratio (pMBM v. tMBM)
Fold change (pMBM v. tMBM)
LSMean (pMBM v. tMBM)
hsa-miR-186-5p 5.03E+02 4.09E-01 5.52E-01 2.73E+00 2.73E+00 8.84E+02hsa-miR-30b-5p 2.98E+03 4.08E-01 5.52E-01 1.13E+00 1.13E+00 2.79E+03hsa-miR-106b-5p 8.86E+02 4.26E-01 5.72E-01 1.44E+00 1.44E+00 9.10E+02hsa-miR-7847-3p 5.70E+02 4.25E-01 5.72E-01 2.93E+00 2.93E+00 1.14E+03hsa-miR-133a-5p 1.66E+02 4.32E-01 5.77E-01 2.85E+00 2.85E+00 4.00E+02hsa-miR-4709-3p 1.72E+02 4.32E-01 5.77E-01 1.82E+00 1.82E+00 2.38E+02hsa-miR-4292 1.46E+02 4.35E-01 5.79E-01 2.30E+00 2.30E+00 2.33E+02hsa-miR-342-3p 1.60E+02 4.40E-01 5.85E-01 3.42E+00 3.42E+00 2.73E+02hsa-miR-4665-3p 3.98E+02 4.43E-01 5.86E-01 2.16E+00 2.16E+00 5.28E+02hsa-miR-611 1.07E+02 4.43E-01 5.86E-01 2.36E+00 2.36E+00 2.04E+02hsa-miR-140-3p 4.26E+02 4.51E-01 5.94E-01 4.32E+00 4.32E+00 1.10E+03hsa-miR-1299 7.31E+02 4.58E-01 6.02E-01 5.52E+00 5.52E+00 1.99E+03hsa-miR-4745-5p 1.26E+02 4.63E-01 6.06E-01 1.94E+00 1.94E+00 1.81E+02hsa-miR-223-3p 1.77E+02 4.66E-01 6.08E-01 2.67E+00 2.67E+00 3.63E+02hsa-miR-30c-5p 6.77E+02 4.67E-01 6.08E-01 1.25E+00 1.25E+00 6.89E+02hsa-miR-141-3p 2.19E+03 4.79E-01 6.15E-01 1.06E+00 1.06E+00 2.15E+03hsa-miR-374b-5p 1.22E+02 4.79E-01 6.15E-01 3.65E+00 3.65E+00 2.39E+02hsa-miR-374c-3p 1.22E+02 4.79E-01 6.15E-01 3.65E+00 3.65E+00 2.39E+02hsa-miR-4707-5p 4.47E+02 4.76E-01 6.15E-01 1.78E+00 1.78E+00 4.92E+02hsa-miR-4769-3p 9.80E+01 4.79E-01 6.15E-01 2.76E+00 2.76E+00 2.01E+02hsa-miR-200b-5p 9.31E+02 4.88E-01 6.25E-01 2.30E+00 2.30E+00 1.52E+03hsa-miR-148a-3p 1.22E+04 5.08E-01 6.47E-01 1.49E+00 1.49E+00 1.44E+04hsa-miR-499a-5p 1.65E+03 5.08E-01 6.47E-01 1.98E+00 1.98E+00 2.42E+03hsa-miR-4466 4.95E+02 5.11E-01 6.50E-01 2.04E+00 2.04E+00 6.07E+02hsa-miR-3922-5p 1.25E+03 5.17E-01 6.52E-01 1.41E+00 1.41E+00 1.50E+03hsa-miR-4433a-3p 5.70E+01 5.19E-01 6.52E-01 2.97E+00 2.97E+00 1.19E+02hsa-miR-4433b-5p 5.70E+01 5.19E-01 6.52E-01 2.97E+00 2.97E+00 1.19E+02hsa-miR-4516 1.79E+03 5.15E-01 6.52E-01 2.17E+00 2.17E+00 2.04E+03hsa-miR-6836-3p 2.35E+03 5.21E-01 6.53E-01 9.40E-01 -1.06E+00 1.78E+03hsa-miR-4469 1.91E+03 5.24E-01 6.55E-01 8.07E-01 -1.24E+00 2.16E+03hsa-miR-5088-3p 2.67E+02 5.28E-01 6.58E-01 2.30E+00 2.30E+00 4.54E+02hsa-miR-378d 4.39E+02 5.29E-01 6.58E-01 1.73E+00 1.73E+00 5.33E+02hsa-let-7i-5p 1.66E+03 5.32E-01 6.60E-01 2.72E+00 2.72E+00 2.84E+03hsa-miR-1245a 2.80E+03 5.34E-01 6.60E-01 1.41E+00 1.41E+00 2.34E+03hsa-miR-146b-5p 5.17E+03 5.37E-01 6.62E-01 1.08E+00 1.08E+00 5.15E+03hsa-miR-6787-5p 3.17E+02 5.43E-01 6.68E-01 3.11E+00 3.11E+00 5.55E+02hsa-miR-422a 5.32E+02 5.51E-01 6.74E-01 1.36E+00 1.36E+00 4.73E+02hsa-miR-6090 3.98E+02 5.50E-01 6.74E-01 3.76E+00 3.76E+00 8.91E+02hsa-miR-3183 1.31E+02 5.55E-01 6.77E-01 2.01E+00 2.01E+00 2.70E+02hsa-miR-6727-3p 2.66E+02 5.56E-01 6.77E-01 4.72E+00 4.72E+00 5.21E+02hsa-miR-8069 3.13E+02 5.58E-01 6.77E-01 1.84E+00 1.84E+00 4.27E+02hsa-miR-224-5p 1.54E+02 5.68E-01 6.85E-01 2.52E+00 2.52E+00 3.54E+02hsa-miR-564 8.05E+04 5.67E-01 6.85E-01 9.12E-01 -1.10E+00 3.68E+04
microRNA ID Total reads
P-value (pMBM v. tMBM)
FDR step up (pMBM v. tMBM)
Ratio (pMBM v. tMBM)
Fold change (pMBM v. tMBM)
LSMean (pMBM v. tMBM)
hsa-miR-718 7.87E+02 5.68E-01 6.85E-01 2.09E+00 2.09E+00 1.06E+03hsa-miR-21-5p 6.29E+03 5.70E-01 6.85E-01 1.76E+00 1.76E+00 9.06E+03hsa-miR-6734-5p 1.53E+02 5.76E-01 6.91E-01 5.33E+00 5.33E+00 4.93E+02hsa-miR-30a-5p 5.18E+03 5.84E-01 6.98E-01 1.37E+00 1.37E+00 5.94E+03hsa-miR-148b-3p 6.86E+02 5.98E-01 7.12E-01 1.07E+00 1.07E+00 6.82E+02hsa-miR-664a-5p 4.46E+02 5.99E-01 7.12E-01 2.68E+00 2.68E+00 7.51E+02hsa-miR-335-5p 3.38E+03 6.15E-01 7.30E-01 1.29E+00 1.29E+00 3.37E+03hsa-miR-589-5p 6.36E+02 6.17E-01 7.30E-01 4.52E+00 4.52E+00 1.84E+03hsa-miR-7641 4.27E+03 6.25E-01 7.37E-01 9.37E-01 -1.07E+00 3.78E+03hsa-miR-4294 3.81E+03 6.30E-01 7.42E-01 1.50E+00 1.50E+00 3.78E+03hsa-miR-99a-5p 1.04E+03 6.41E-01 7.53E-01 2.19E+00 2.19E+00 1.48E+03hsa-miR-499b-3p 2.92E+02 6.44E-01 7.54E-01 9.78E-01 -1.02E+00 2.47E+02hsa-miR-1183 7.25E+02 6.49E-01 7.58E-01 1.76E+00 1.76E+00 6.90E+02hsa-miR-1292-3p 2.51E+02 6.52E-01 7.60E-01 2.80E+00 2.80E+00 4.12E+02hsa-miR-493-5p 1.43E+03 6.57E-01 7.63E-01 1.55E+00 1.55E+00 1.31E+03hsa-miR-4776-3p 5.80E+01 6.63E-01 7.69E-01 1.48E+00 1.48E+00 7.53E+01hsa-miR-4530 5.43E+02 6.71E-01 7.74E-01 1.72E+00 1.72E+00 6.17E+02hsa-miR-6850-3p 1.25E+02 6.69E-01 7.74E-01 3.33E+00 3.33E+00 2.19E+02hsa-miR-4532 1.09E+03 6.80E-01 7.80E-01 1.81E+00 1.81E+00 1.19E+03hsa-miR-6799-3p 8.20E+01 6.78E-01 7.80E-01 5.95E+00 5.95E+00 2.31E+02hsa-miR-191-5p 2.49E+03 7.08E-01 8.09E-01 2.14E+00 2.14E+00 3.53E+03hsa-miR-28-3p 1.55E+02 7.08E-01 8.09E-01 2.86E+00 2.86E+00 3.01E+02hsa-miR-200a-3p 4.22E+03 7.11E-01 8.10E-01 1.41E+00 1.41E+00 4.84E+03hsa-miR-330-3p 1.71E+02 7.14E-01 8.11E-01 2.46E+00 2.46E+00 2.80E+02hsa-miR-1199-5p 4.40E+02 7.20E-01 8.13E-01 2.56E+00 2.56E+00 6.21E+02hsa-miR-224-3p 6.26E+02 7.18E-01 8.13E-01 2.55E+00 2.55E+00 1.08E+03hsa-miR-99b-5p 4.24E+02 7.20E-01 8.13E-01 2.34E+00 2.34E+00 6.91E+02hsa-miR-182-5p 1.36E+03 7.28E-01 8.18E-01 2.22E+00 2.22E+00 2.18E+03hsa-miR-5701 6.94E+02 7.28E-01 8.18E-01 6.58E-01 -1.52E+00 1.18E+03hsa-miR-7978 1.89E+03 7.31E-01 8.19E-01 9.93E-01 -1.01E+00 2.50E+03hsa-miR-1249-5p 1.14E+02 7.48E-01 8.34E-01 1.78E+00 1.78E+00 1.41E+02hsa-miR-3907 9.79E+02 7.50E-01 8.34E-01 1.28E+00 1.28E+00 9.28E+02hsa-miR-637 2.68E+02 7.50E-01 8.34E-01 2.18E+00 2.18E+00 3.68E+02hsa-miR-25-3p 6.66E+02 7.52E-01 8.35E-01 1.89E+00 1.89E+00 9.39E+02hsa-miR-6831-5p 3.74E+02 7.60E-01 8.42E-01 3.32E+00 3.32E+00 6.42E+02hsa-miR-3184-3p 2.86E+02 7.64E-01 8.42E-01 3.23E+00 3.23E+00 4.54E+02hsa-miR-423-5p 2.86E+02 7.64E-01 8.42E-01 3.23E+00 3.23E+00 4.54E+02hsa-let-7d-5p 7.23E+02 7.67E-01 8.44E-01 2.04E+00 2.04E+00 1.14E+03hsa-miR-6085 9.80E+01 7.70E-01 8.44E-01 2.35E+00 2.35E+00 1.43E+02hsa-miR-3176 1.46E+02 7.74E-01 8.47E-01 1.86E+00 1.86E+00 1.86E+02hsa-miR-1224-3p 9.50E+01 7.77E-01 8.48E-01 2.41E+00 2.41E+00 1.48E+02hsa-miR-23b-3p 2.24E+02 7.86E-01 8.56E-01 2.85E+00 2.85E+00 3.70E+02hsa-miR-3074-3p 1.08E+02 7.98E-01 8.64E-01 5.12E+00 5.12E+00 2.37E+02
microRNA ID Total reads
P-value (pMBM v. tMBM)
FDR step up (pMBM v. tMBM)
Ratio (pMBM v. tMBM)
Fold change (pMBM v. tMBM)
LSMean (Premie) (pMBM v. tMBM)
hsa-miR-3666 3.53E+04 7.98E-01 8.64E-01 9.39E-01 -1.06E+00 2.37E+04hsa-miR-16-5p 1.51E+03 8.02E-01 8.67E-01 1.77E+00 1.77E+00 2.05E+03hsa-miR-4443 2.23E+03 8.08E-01 8.70E-01 2.14E+00 2.14E+00 2.78E+03hsa-miR-506-5p 8.80E+01 8.08E-01 8.70E-01 4.03E+00 4.03E+00 2.11E+02hsa-miR-6089 1.30E+03 8.15E-01 8.73E-01 1.30E+00 1.30E+00 1.41E+03hsa-miR-921 1.81E+02 8.15E-01 8.73E-01 5.68E+00 5.68E+00 5.00E+02hsa-miR-522-3p 3.95E+02 8.23E-01 8.80E-01 1.11E+00 1.11E+00 3.34E+02hsa-miR-4707-3p 1.41E+02 8.25E-01 8.80E-01 2.78E+00 2.78E+00 2.32E+02hsa-miR-6746-3p 3.10E+02 8.34E-01 8.83E-01 3.64E+00 3.64E+00 4.98E+02hsa-miR-6789-5p 1.89E+03 8.33E-01 8.83E-01 1.68E+00 1.68E+00 2.46E+03hsa-miR-7977 3.74E+03 8.32E-01 8.83E-01 8.52E-01 -1.17E+00 2.37E+03hsa-miR-6762-5p 1.18E+02 8.38E-01 8.86E-01 2.71E+00 2.71E+00 1.67E+02hsa-miR-146a-5p 6.91E+02 8.45E-01 8.86E-01 5.17E+00 5.17E+00 1.54E+03hsa-miR-663a 8.33E+02 8.43E-01 8.86E-01 1.36E+00 1.36E+00 9.39E+02hsa-miR-6748-5p 1.18E+02 8.41E-01 8.86E-01 2.49E+00 2.49E+00 1.99E+02hsa-miR-8072 4.62E+02 8.46E-01 8.86E-01 3.43E+00 3.43E+00 7.43E+02hsa-miR-200b-3p 2.99E+03 8.50E-01 8.88E-01 2.59E+00 2.59E+00 4.63E+03hsa-miR-30a-3p 1.32E+03 8.52E-01 8.88E-01 3.70E+00 3.70E+00 2.36E+03hsa-miR-3960 2.54E+03 8.58E-01 8.92E-01 1.64E+00 1.64E+00 2.77E+03hsa-miR-4454 3.65E+04 8.62E-01 8.92E-01 9.92E-01 -1.01E+00 2.53E+04hsa-miR-6869-5p 8.47E+02 8.61E-01 8.92E-01 3.92E+00 3.92E+00 1.38E+03hsa-miR-4655-3p 2.63E+02 8.72E-01 9.01E-01 4.29E+00 4.29E+00 4.54E+02hsa-miR-192-5p 1.68E+02 8.75E-01 9.02E-01 4.07E+00 4.07E+00 3.28E+02hsa-miR-125b-2-3p 9.03E+02 8.85E-01 9.11E-01 3.23E+00 3.23E+00 1.60E+03hsa-miR-3614-3p 5.84E+02 8.95E-01 9.18E-01 1.22E+00 1.22E+00 5.86E+02hsa-miR-146b-3p 6.90E+02 9.00E-01 9.22E-01 1.34E+00 1.34E+00 8.49E+02hsa-miR-22-3p 4.34E+03 9.09E-01 9.28E-01 1.26E+00 1.26E+00 4.88E+03hsa-miR-574-3p 1.84E+02 9.13E-01 9.31E-01 2.22E+00 2.22E+00 2.63E+02hsa-miR-324-3p 1.46E+02 9.28E-01 9.45E-01 2.21E+00 2.21E+00 2.64E+02hsa-miR-6880-5p 9.83E+02 9.31E-01 9.45E-01 1.62E+00 1.62E+00 1.07E+03hsa-miR-1470 9.70E+01 9.37E-01 9.48E-01 1.67E+00 1.67E+00 1.43E+02hsa-miR-4632-3p 2.21E+02 9.38E-01 9.48E-01 1.60E+00 1.60E+00 4.01E+02hsa-miR-195-5p 1.57E+02 9.44E-01 9.52E-01 3.03E+00 3.03E+00 3.39E+02hsa-miR-769-3p 1.74E+02 9.54E-01 9.60E-01 3.85E+00 3.85E+00 3.77E+02hsa-miR-7114-3p 2.65E+02 9.85E-01 9.89E-01 2.06E+00 2.06E+00 3.63E+02hsa-miR-5694 2.74E+02 9.88E-01 9.90E-01 5.19E+00 5.19E+00 6.85E+02hsa-miR-200a-5p 2.15E+02 9.93E-01 9.93E-01 2.47E+00 2.47E+00 3.61E+02
Abbreviations: FDR = Benjamini Hochberg False Detection Rate, LSMean = least-squares mean, pMBM = premature maternal breast milk, tMBM = term maternal breast milk.
Supplementary Table S2. The miRNAs “altered” in lipid pMBM target mRNAs enriched in 90 gene ontology (GO) processes (A) and 24 KEGG Pathways (B), many of which are related to metabolic regulation and biosynthesis.
A BGO Category FDR genes (n) miRNAs (n) KEGG pathway FDR genes (n)organelle 1.35E-96 1877 14 Arrhythmogenic right ventricular
cardiomyopathy (ARVC)0.0007 22
ion binding 3.49E-68 1216 14 Lysine degradation 0.0007 14cellular nitrogen compound metabolic process
1.36E-61 960 14 FoxO signaling pathway 0.0007 37
biosynthetic process 3.57E-35 777 14 Ubiquitin mediated proteolysis 0.0012 38cellular protein modification process
1.99E-28 479 14 Thyroid hormone signaling pathway
0.0014 32
gene expression 2.47E-24 142 13 Pathways in cancer 0.0017 94Molecular function 4.28E-19 2986 14 Wnt signaling pathway 0.0041 37nucleic acid binding transcription factor activity
1.03E-16 219 14 Valine, leucine and isoleucine biosynthesis
0.0129 2
catabolic process 8.96E-15 369 14 Insulin secretion 0.0129 26protein complex 7.75E-14 694 14 TGF-beta signaling pathway 0.0187 20neurotrophin TRK receptor signaling pathway
6.52E-13 62 13 Signaling pathways regulating pluripotency of stem cells
0.0187 35
symbiosis, encompassing mutualism through parasitism
1.06E-12 111 13 Ras signaling pathway 0.0192 54
small molecule metabolic process
1.23E-12 413 13 Protein processing in endoplasmic reticulum
0.0192 42
viral process 3.01E-12 99 13 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate
0.0270 7
nucleoplasm 6.20E-12 240 14 Glycosaminoglycan biosynthesis - heparan sulfate / heparin
0.0270 8
Fc-epsilon receptor signaling pathway
1.15E-11 43 13 mTOR signaling pathway 0.0270 20
enzyme binding 1.15E-11 253 14 Oxytocin signaling pathway 0.0271 38
GO Category FDR genes (n) miRNAs (n) KEGG pathway FDR genes (n)Cellular component 1.19E-10 2972 14 Circadian rhythm 0.0311 12
protein binding transcription factor activity
1.24E-10 108 13 Adherens junction 0.0311 19
nucleobase-containing compound catabolic process
2.53E-09 175 14 Renal cell carcinoma 0.031096615
18
epidermal growth factor receptor signaling pathway
3.89E-09 55 13 AMPK signaling pathway 0.031096615
32
cellular component assembly 5.51E-09 241 14 Cell adhesion molecules (CAMs) 0.031096615
31
synaptic transmission 3.77E-07 90 13 Basal cell carcinoma 0.036661464
17
mitotic cell cycle 4.93E-07 75 13 Transcriptional misregulation in cancer
0.036661464
47
macromolecular complex assembly
6.93E-07 163 14
cellular protein metabolic process
1.02E-06 83 14
cytosol 2.76E-06 472 14membrane organization 2.97E-06 110 13blood coagulation 3.24E-06 84 13cell death 3.76E-06 170 14
phosphatidylinositol-mediated signaling
4.87E-06 37 13
cytoskeletal protein binding 4.87E-06 146 14
fibroblast growth factor receptor signaling pathway
3.35E-05 45 13
Biological process 3.35E-05 2843 14
post-translational protein modification
6.47E-05 34 13
cell-cell signaling 6.91E-05 123 13
GO Category FDR genes (n) miRNAs (n)transcription, DNA-templated 7.83E-05 451 14
platelet activation 0.0004 41 12transmembrane transporter activity
0.0005 189 13
cellular lipid metabolic process 0.0005 30 13energy reserve metabolic process
0.0006 24 10
DNA metabolic process 0.0007 137 14
small conjugating protein binding 0.0008 25 14toll-like receptor 10 signaling pathway
0.0010 15 9
response to stress 0.0010 364 14toll-like receptor 9 signaling pathway
0.0014 17 10
protein complex assembly 0.0017 131 13
TRIF-dependent toll-like receptor signaling pathway
0.0019 16 10
mRNA metabolic process 0.0020 38 12
cytoskeleton-dependent intracellular transport
0.0021 27 11
toll-like receptor TLR1:TLR2 signaling pathway
0.0021 15 9
toll-like receptor TLR6:TLR2 signaling pathway
0.0021 15 9
Fc-gamma receptor signaling pathway involved in phagocytosis
0.0021 16 10
RNA metabolic process 0.0023 44 13
cellular component disassembly involved in execution phase of apoptosis
0.0025 12 9
GO Category FDR genes (n) miRNAs (n)
toll-like receptor 5 signaling pathway
0.0046 15 9
activation of signaling protein activity involved in unfolded protein response
0.0059 15 8
cell junction assembly 0.0059 15 11microtubule organizing center 0.0059 86 13
MyD88-independent toll-like receptor signaling pathway
0.0070 16 10
integral component of plasma membrane
0.0075 220 13
junctional sarcoplasmic reticulum membrane
0.0092 6 5
toll-like receptor signaling pathway
0.0092 23 13
platelet degranulation 0.0097 16 10
ribonucleoprotein complex assembly
0.0097 32 12
RNA binding 0.0108 305 14
toll-like receptor 4 signaling pathway
0.0111 20 11
in utero embryonic development 0.0111 74 14C-terminal protein lipidation 0.0114 9 10
transcription initiation from RNA polymerase II promoter
0.0114 43 12
adherens junction organization 0.0122 13 8
post-Golgi vesicle-mediated transport
0.0140 13 8
GO Category FDR genes (n) miRNAs (n)
nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
0.0145 15 9
toll-like receptor 2 signaling pathway
0.0179 16 9
nucleobase-containing small molecule metabolic process
0.0239 14 9
toll-like receptor 3 signaling pathway
0.0272 16 10
enzyme regulator activity 0.0272 134 13
homeostatic process 0.0290 137 13
vesicle-mediated transport 0.0290 176 13
G2/M transition of mitotic cell cycle
0.0310 29 11
phospholipid metabolic process 0.0353 32 10
chondroitin sulfate metabolic process
0.0360 11 6
protein binding, bridging 0.0366 32 13
cell junction organization 0.0383 29 11sphingolipid biosynthetic process 0.0409 12 8
inositol phosphate metabolic process
0.0435 10 7
cell motility 0.0448 96 13
glycosaminoglycan metabolic process
0.0468 19 8
chromatin organization 0.0486 25 8
insulin receptor signaling pathway
0.0490 33 12
Supplementary Table S3. All miRNAs detected in the skim fraction of pMBM and tMBM
P-value(pMBM v. tMBM)
FDR step up(pMBM v. tMBM)
Ratio(pMBM v. tMBM)
Fold change (pMBM v. tMBM)
LSMean(pMBM v. tMBM)
4.93E-06 1.58E-04 4.72E-01 -2.12E+00 1.67E+044.23E-05 6.40E-04 5.26E-01 -1.90E+00 2.36E+046.00E-05 6.40E-04 2.50E+00 2.50E+00 2.04E+039.33E-05 7.47E-04 5.66E-01 -1.77E+00 3.25E+041.25E-04 7.84E-04 6.04E-01 -1.66E+00 3.75E+041.71E-04 7.84E-04 5.92E-01 -1.69E+00 2.18E+041.56E-04 7.84E-04 5.99E-01 -1.67E+00 8.15E+032.26E-04 9.03E-04 2.12E+00 2.12E+00 7.27E+034.45E-03 1.58E-02 1.76E+00 1.76E+00 6.36E+035.28E-03 1.69E-02 1.69E+00 1.69E+00 8.55E+031.07E-02 3.11E-02 2.24E+00 2.24E+00 2.98E+031.86E-02 4.97E-02 7.22E-01 -1.39E+00 2.41E+043.27E-02 8.06E-02 7.97E-01 -1.26E+00 1.08E+044.55E-02 9.72E-02 1.20E+00 1.20E+00 9.15E+034.56E-02 9.72E-02 7.14E-01 -1.40E+00 7.65E+035.48E-02 1.10E-01 7.84E-01 -1.28E+00 1.68E+047.68E-02 1.41E-01 7.16E-01 -1.40E+00 8.16E+037.90E-02 1.41E-01 1.49E+00 1.49E+00 6.85E+038.41E-02 1.42E-01 1.64E+00 1.64E+00 5.01E+031.06E-01 1.69E-01 8.48E-01 -1.18E+00 1.09E+041.23E-01 1.87E-01 6.74E-01 -1.48E+00 1.82E+031.57E-01 2.29E-01 9.66E-01 -1.04E+00 4.19E+042.59E-01 3.61E-01 8.38E-01 -1.19E+00 1.05E+033.58E-01 4.77E-01 1.20E+00 1.20E+00 2.47E+033.81E-01 4.87E-01 8.85E-01 -1.13E+00 3.09E+045.06E-01 6.04E-01 9.24E-01 -1.08E+00 1.65E+045.09E-01 6.04E-01 8.53E-01 -1.17E+00 6.31E+045.80E-01 6.63E-01 1.23E+00 1.23E+00 5.38E+036.35E-01 7.01E-01 1.61E+00 1.61E+00 1.81E+038.07E-01 8.60E-01 8.62E-01 -1.16E+00 3.54E+048.96E-01 9.25E-01 1.56E+00 1.56E+00 7.96E+039.54E-01 9.54E-01 8.79E-01 -1.14E+00 3.63E+04
Abbreviations: pMBM = premature maternal breast milk, tMBM = term maternal breast milk
Supplementary Table S4. The miRNAs “altered” in skim pMBM target mRNAs enriched in 10 gene ontology (GO) processes (A) and 9 KEGG Pathways (B), many of which are related to metabolism and biosynthesis.
A B
GO Category FDRgenes (n) miRNAs (n) KEGG pathway FDR
genes (n) miRNAs (n)
cellular nitrogen compound metabolic process
3.60E-62 484 5 Glycosphingolipid biosynthesis - ganglio series
5.24E-09 6 4
organelle 4.10E-44 1108 7 Lysine degradation 0.0144 10 5ion binding 2.10E-13 668 6 Calcium signaling pathway 0.0144 32 5biosynthetic process 4.67E-09 302 3 Adherens junction 0.0144 17 10
nucleic acid binding transcription factor activity
4.06E-06 114 3Circadian entrainment
0.0183 22 6
symbiosis, encompassing mutualism through parasitism
0.0012 32 1 Glycosphingolipid biosynthesis - globo series
0.0226 5 2
cellular protein modification process
0.0024 134 2Oxytocin signaling pathway
0.0226 31 9
viral process 0.0088 26 1 2-Oxocarboxylic acid metabolism 0.0326 4 5
homophilic cell adhesion via plasma membrane adhesion molecules
0.0136 44 2 Arrhythmogenic right ventricular cardiomyopathy (ARVC)
0.0326 16 6
protein binding transcription factor activity 0.0261 30 1
Supplementary Table S5. The nine miRNAs “altered” in both lipid and skim fractions of pMBM target mRNAs enriched in 42 gene ontology (GO) processes (A) and 5 KEGG Pathways (B)
A B
GO Category FDR genes (n) miRNAs (n) KEGG pathway FDR genes (n)miRNAs (n)
organelle (GO:0043226) 2.74E-42 1091 8
Glycosphingolipid biosynthesis - ganglio series(hsa00604)
9.32E-09 5 3
cellular nitrogen compound metabolic process (GO:0034641)
9.84E-32 569 8 Lysine
degradation (hsa00310) 0.0037 10 5
ion binding (GO:0043167) 4.30E-28 694 8 Calcium signaling
pathway (hsa04020) 0.0037 32 5
biosynthetic process (GO:0009058)
1.71E-19 468 8 Adherens
junction (hsa04520) 0.0092 16 8
nucleic acid binding transcription factor activity (GO:0001071)
3.28E-12 142 8
Arrhythmogenic right ventricular cardiomyopathy (ARVC) (hsa05412)
0.0184 16 5
cellular protein modification process (GO:0006464)
4.38E-10 265 8
neurotrophin TRK receptor signaling pathway (GO:0048011)
7.02E-09 41 8
symbiosis, encompassing mutualism through parasitism (GO:0044403)
5.30E-08 70 8
viral process (GO:0016032) 1.74E-07 62 8
molecular_function (GO:0003674)
7.39E-06 1780 8
protein binding transcription factor activity (GO:0000988)
1.36E-05 65 8
gene expression (GO:0010467)
1.96E-05 65 6
small molecule metabolic process (GO:0044281) 0.0001 236 8
nucleoplasm (GO:0005654) 0.0001 136 8
cellular component assembly (GO:0022607) 0.0002 144 8
cellular_component (GO:0005575) 0.0003 1790 8
cytoskeletal protein binding (GO:0008092) 0.0006 92 8
blood coagulation (GO:0007596) 0.0007 53 8
catabolic process (GO:0009056) 0.0008 198 8
homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)
0.0012 52 5
enzyme binding (GO:0019899) 0.0017 138 8
synaptic transmission (GO:0007268) 0.0018 53 8
cell-cell signaling (GO:0007267) 0.0074 76 8
integral component of plasma membrane (GO:0005887) 0.0074 145 8
macromolecular complex assembly (GO:0065003) 0.0080 94 8
mitotic cell cycle (GO:0000278) 0.0083 42 7
protein complex (GO:0043234) 0.0086 379 8
cellular component disassembly involved in execution phase of apoptosis
0.0103 9 5
(GO:0006921)energy reserve metabolic process (GO:0006112)
0.0105 16 6
transcription, DNA-templated (GO:0006351) 0.0112 274 8
epidermal growth factor receptor signaling pathway (GO:0007173)
0.0146 27 7
nucleobase-containing compound catabolic process (GO:0034655)
0.0148 93 8
cell junction assembly (GO:0034329) 0.0188 11 6
Fc-gamma receptor signaling pathway involved in phagocytosis (GO:0038096)
0.0204 11 5
glycosaminoglycan metabolic process (GO:0030203) 0.0275 15 4
protein complex assembly (GO:0006461) 0.0275 82 8
transmembrane transporter activity (GO:0022857) 0.0412 114 8
cell junction organization (GO:0034330) 0.0472 21 6
post-translational protein modification (GO:0043687) 0.0472 19 7
cell death (GO:0008219) 0.0472 95 8
membrane organization (GO:0061024) 0.0473 60 8
inositol phosphate metabolic process (GO:0043647) 0.0495 8 5
Supplementary Table S6. miRNAs with significant differences between pMBM (collected 3-4 weeks post-delivery), tMBM (collected 3-4 weeks post-delivery) and term colostrum
MicroRNA Chi Squared KW pval -Log10 FDRhsa-miR-639 38.173 5.14E-09 8.2892 5.46E-07hsa-miR-6772-3p 38.159 5.17E-09 8.2861 5.46E-07hsa-miR-4668-5p 33.748 4.70E-08 7.3282 2.68E-06hsa-miR-1303 33.282 5.93E-08 7.2271 2.68E-06hsa-miR-3655 33.148 6.34E-08 7.1979 2.68E-06hsa-miR-491-3p 31.825 1.23E-07 6.9107 3.69E-06hsa-miR-2276-3p 31.817 1.23E-07 6.909 3.69E-06hsa-miR-208b-3p 31.567 1.40E-07 6.8547 3.69E-06hsa-miR-15a-5p 30.612 2.25E-07 6.6472 5.28E-06hsa-miR-375 29.358 4.22E-07 6.3751 8.90E-06hsa-miR-30d-5p 28.836 5.47E-07 6.2617 1.05E-05hsa-miR-3934-5p 27.816 9.12E-07 6.0401 1.60E-05hsa-miR-30b-5p 27.3 1.18E-06 5.9282 1.91E-05hsa-miR-3614-3p 27.114 1.30E-06 5.8877 1.95E-05hsa-miR-7641 26.095 2.16E-06 5.6665 3.03E-05hsa-miR-7704 25.326 3.17E-06 5.4995 4.18E-05hsa-let-7d-3p 24.982 3.76E-06 5.4248 4.46E-05hsa-miR-183-5p 24.958 3.81E-06 5.4196 4.46E-05hsa-miR-4687-3p 24.301 5.29E-06 5.2768 5.55E-05hsa-miR-4680-3p 24.146 5.71E-06 5.2433 5.55E-05hsa-miR-3195 24.127 5.77E-06 5.2391 5.55E-05hsa-miR-4286 24.122 5.78E-06 5.2379 5.55E-05hsa-miR-193b-3p 23.636 7.37E-06 5.1325 6.76E-05hsa-miR-4454 22.38 1.38E-05 4.8597 0.0001
hsa-miR-668-3p 22.238 1.48E-05 4.8288 0.0001
hsa-miR-3944-5p 22.136 1.56E-05 4.8067 0.0001
hsa-miR-6871-3p 21.861 1.79E-05 4.7472 0.0001
hsa-miR-6090 21.357 2.30E-05 4.6376 0.0002
hsa-miR-30e-5p 20.171 4.17E-05 4.38 0.0003
hsa-miR-1260a 20.064 4.40E-05 4.3568 0.0003
hsa-miR-499a-5p 19.801 5.02E-05 4.2997 0.0003
hsa-miR-182-5p 19.694 5.29E-05 4.2764 0.0003
hsa-miR-650 19.576 5.61E-05 4.2509 0.0004
hsa-miR-1260b 19.369 6.22E-05 4.2059 0.0004
hsa-miR-4492 19.276 6.52E-05 4.1858 0.0004
hsa-miR-429 19.055 7.28E-05 4.1377 0.0004
hsa-miR-4664-5p 19.018 7.42E-05 4.1297 0.0004
hsa-miR-6757-5p 18.701 8.69E-05 4.061 0.0005
hsa-miR-5010-3p 18.11 0.00011682 3.9325 0.0006
hsa-miR-378a-3p 16.843 0.00022007 3.6574 0.0011
hsa-miR-7977 16.819 0.00022271 3.6523 0.0011
hsa-miR-7975 16.628 0.00024507 3.6107 0.0012
hsa-miR-589-5p 16.595 0.00024917 3.6035 0.0012
hsa-miR-146b-5p 16.585 0.00025037 3.6014 0.0012
hsa-miR-4294 16.162 0.00030932 3.5096 0.0015
hsa-miR-1913 16.097 0.00031961 3.4954 0.0015
hsa-miR-378g 15.935 0.00034652 3.4603 0.0016
hsa-miR-6765-5p 15.404 0.00045198 3.3449 0.0020
hsa-miR-378c 15.277 0.00048153 3.3174 0.0021
hsa-miR-1343-5p 15.04 0.00054215 3.2659 0.0023
hsa-miR-22-3p 14.946 0.00056819 3.2455 0.0024
hsa-miR-212-5p 14.715 0.00063775 3.1954 0.0026
hsa-miR-378i 14.671 0.00065212 3.1857 0.0026
hsa-miR-6821-5p 14.667 0.00065339 3.1848 0.0026
hsa-miR-200b-5p 14.535 0.00069787 3.1562 0.0027
hsa-miR-663a 14.401 0.00074625 3.1271 0.0028
hsa-miR-5787 14.154 0.00084434 3.0735 0.0031
hsa-miR-200a-3p 13.917 0.00095037 3.0221 0.0035
hsa-miR-3134 13.859 0.00097867 3.0094 0.0035
hsa-miR-3907 13.78 0.0010178 2.9923 0.0036
hsa-miR-1180-5p 13.642 0.0010905 2.9624 0.0038
hsa-miR-3621 13.581 0.0011245 2.949 0.0038
hsa-miR-493-5p 13.335 0.0012715 2.8957 0.0043
hsa-miR-21-5p 13.106 0.0014256 2.846 0.0047
hsa-miR-6724-5p 13.087 0.0014393 2.8419 0.0047
hsa-miR-6836-3p 13.018 0.0014899 2.8268 0.0047
hsa-miR-1245a 12.983 0.0015163 2.8192 0.0047
hsa-miR-148b-3p 12.95 0.0015411 2.8122 0.0047
hsa-miR-5196-3p 12.94 0.0015489 2.81 0.0047
hsa-let-7g-3p 12.923 0.0015626 2.8061 0.0047
hsa-miR-4783-3p 12.917 0.001567 2.8049 0.0047
hsa-miR-1908-5p 12.732 0.0017189 2.7647 0.0050
hsa-miR-148a-3p 12.271 0.0021649 2.6646 0.0063
hsa-miR-29a-3p 12.19 0.0022542 2.647 0.0064
hsa-miR-6865-5p 12.05 0.0024178 2.6166 0.0068
hsa-miR-522-3p 11.992 0.0024884 2.6041 0.0069
hsa-let-7g-5p 11.958 0.0025308 2.5967 0.0069
hsa-miR-3181 11.898 0.0026088 2.5836 0.0071
hsa-miR-6804-5p 11.639 0.0029697 2.5273 0.0079
hsa-miR-141-3p 11.56 0.0030886 2.5102 0.0081
hsa-miR-6089 11.509 0.0031682 2.4992 0.0083
hsa-miR-422a 11.478 0.0032178 2.4924 0.0083
hsa-miR-4739 11.449 0.003265 2.4861 0.0083
hsa-miR-378h 11.396 0.0033534 2.4745 0.0084
hsa-miR-7978 11.226 0.0036498 2.4377 0.0091
hsa-miR-4530 11.144 0.0038025 2.4199 0.0093
hsa-miR-103a-3p 11.08 0.0039266 2.406 0.0094
hsa-miR-4695-3p 11.069 0.003948 2.4036 0.0094
hsa-miR-4540 11.067 0.0039513 2.4033 0.0094
hsa-miR-103b 11.022 0.0040421 2.3934 0.0095
hsa-miR-598-5p 10.936 0.0042187 2.3748 0.0098
hsa-miR-1469 10.9 0.004296 2.3669 0.0099
hsa-miR-564 10.804 0.0045078 2.346 0.0102
hsa-miR-4469 10.717 0.0047074 2.3272 0.0106
hsa-miR-3141 10.664 0.0048346 2.3156 0.0107
hsa-miR-5196-5p 10.635 0.0049051 2.3094 0.0108
hsa-miR-301b-5p 10.582 0.0050365 2.2979 0.0110
hsa-miR-1193 10.47 0.0053275 2.2735 0.0115
hsa-miR-3666 10.44 0.0054079 2.267 0.0115
hsa-miR-501-5p 10.433 0.0054266 2.2655 0.0115
hsa-miR-146a-5p 10.23 0.0060057 2.2214 0.0125
hsa-miR-224-3p 10.17 0.0061876 2.2085 0.0128
hsa-miR-146b-3p 10.112 0.006372 2.1957 0.0131
hsa-miR-30c-5p 10.034 0.0066242 2.1789 0.0134
hsa-miR-4632-3p 9.9152 0.0070296 2.1531 0.0141
hsa-miR-4781-3p 9.7575 0.0076066 2.1188 0.0151
hsa-miR-106b-5p 9.6433 0.0080535 2.094 0.0159
hsa-miR-1908-3p 9.43 0.00896 2.0477 0.0175
hsa-miR-578 9.3466 0.0093413 2.0296 0.0181
hsa-miR-499b-3p 9.1417 0.010349 1.9851 0.0199
hsa-miR-27a-3p 8.9238 0.011541 1.9378 0.0219
hsa-miR-3184-5p 8.9118 0.01161 1.9352 0.0219
hsa-miR-6805-3p 8.6761 0.013062 1.884 0.0244
hsa-miR-6790-3p 8.6323 0.013351 1.8745 0.0247
hsa-miR-4787-5p 8.5551 0.013877 1.8577 0.0253
hsa-miR-378a-5p 8.5534 0.013889 1.8573 0.0253
hsa-miR-4298 8.5251 0.014086 1.8512 0.0254
hsa-miR-30a-5p 8.4588 0.014561 1.8368 0.0260
hsa-miR-3196 8.1884 0.016669 1.7781 0.0296
hsa-miR-508-3p 7.8133 0.020108 1.6966 0.0354
hsa-miR-4785 7.6789 0.021505 1.6675 0.0375
hsa-miR-4497 7.5477 0.022963 1.639 0.0397
hsa-miR-335-5p 7.2667 0.026427 1.5779 0.0449
hsa-miR-4693-3p 7.2558 0.026571 1.5756 0.0449
hsa-miR-1237-5p 7.2541 0.026594 1.5752 0.0449
hsa-miR-6765-3p 7.092 0.02884 1.54 0.0483
hsa-miR-4741 7.0091 0.03006 1.522 0.0499
hsa-miR-1299 6.9704 0.030648 1.5136 0.0505
hsa-miR-3922-5p 6.8375 0.032753 1.4847 0.0536
hsa-miR-762 6.5122 0.038539 1.4141 0.0626
hsa-miR-200b-3p 6.4639 0.03948 1.4036 0.0636
hsa-miR-1263 6.439 0.039975 1.3982 0.0639
hsa-miR-4488 6.2978 0.0429 1.3675 0.0681
hsa-miR-6789-3p 6.1721 0.045681 1.3403 0.0719
hsa-miR-4634 6.0672 0.048141 1.3175 0.0752
hsa-miR-8077 5.9958 0.049892 1.302 0.0774
Supplementary Table S7. Twenty-one of the 26 miRNAs “altered” in skim or lipid pMBM show significant correlations with gestational age, but few correlations with other medical/demographic characteristics, aside from method of delivery.
Gestational Age Maternal HTN Infant Sex Delivery Method Maternal Ethnicity Twin GestationPearson R FDR Pearson R FDR Pearson R FDR Pearson R FDR Pearson R FDR Pearson R FDR
Gestational Age 1.0000 0.0000 -0.2786 0.2533 0.1583 0.4420 -0.3496 0.0394 0.0458 0.9102 -0.1619 0.4205L miR-4687-3p 0.5472 0.0003 -0.2345 0.3511 0.3323 0.1568 -0.4918 0.0026 0.0792 0.8535 -0.2301 0.2221L miR-1260a 0.5316 0.0004 -0.0295 0.9154 0.1309 0.4750 -0.4034 0.0164 -0.0676 0.8626 -0.0911 0.6501L miR-1260b 0.5123 0.0005 -0.0522 0.8654 0.1379 0.4750 -0.3682 0.0290 -0.0927 0.8295 -0.0732 0.6812L miR-4474-5p -0.5126 0.0005 0.3600 0.1237 -0.0911 0.6264 0.4611 0.0050 -0.0006 0.9963 0.2364 0.2221L miR-378a-3p 0.4925 0.0008 -0.1819 0.5172 0.2005 0.4420 -0.2058 0.2649 -0.1908 0.4241 -0.2639 0.2221L miR-378c 0.4893 0.0008 -0.2179 0.3511 0.1336 0.4750 -0.1751 0.3389 -0.2028 0.4217 -0.2213 0.2321L miR-378g 0.4827 0.0009 -0.2376 0.3511 0.1722 0.4420 -0.2013 0.2649 -0.2068 0.4217 -0.2564 0.2221S miR-4783-3p -0.4810 0.0009 -0.0339 0.9154 0.0115 0.9635 0.4060 0.0164 0.1347 0.6436 0.1161 0.5548L miR-6772-3p -0.4650 0.0013 0.1295 0.5785 -0.0759 0.6901 0.3770 0.0272 -0.0453 0.9102 0.1323 0.5348L miR-4783-3p -0.4470 0.0019 0.1508 0.5415 -0.1930 0.4420 0.3300 0.0543 0.1786 0.4625 0.1392 0.5206S miR-1260a 0.4470 0.0019 -0.0039 0.9777 0.1784 0.4420 -0.2337 0.1958 -0.1255 0.6705 0.0226 0.8982S miR-1260b 0.4242 0.0035 0.0088 0.9777 0.1655 0.4420 -0.2399 0.1901 -0.1660 0.4750 0.0854 0.6512S miR-378a-3p 0.4136 0.0044 -0.1444 0.5415 0.1874 0.4420 -0.1285 0.4500 -0.2568 0.4217 -0.2463 0.2221L miR-4470 -0.4068 0.0050 0.3370 0.1397 -0.0215 0.9340 0.2600 0.1584 -0.0021 0.9963 0.2431 0.2221L miR-6510-5p 0.3977 0.0060 -0.0842 0.7525 -0.1398 0.4750 -0.1655 0.3546 0.2013 0.4217 -0.0273 0.8982S miR-378g 0.3930 0.0064 -0.1536 0.5415 0.1698 0.4420 -0.1556 0.3593 -0.2170 0.4217 -0.2651 0.2221L miR-6763-3p 0.3872 0.0070 -0.2727 0.2533 0.0335 0.8909 -0.1639 0.3546 0.0202 0.9947 -0.2843 0.2221L miR-5585-5p 0.3697 0.0103 -0.1402 0.5415 0.1049 0.5942 -0.1490 0.3727 -0.1036 0.7921 0.1160 0.5548S miR-5787 -0.3530 0.0146 0.1420 0.5415 -0.2527 0.3588 0.2040 0.2649 0.0168 0.9947 0.1200 0.5548Delivery -0.3496 0.0150 0.0903 0.7525 -0.1578 0.4420 1.0000 0.0000 -0.0878 0.8295 0.3051 0.2221S miR-378c 0.3421 0.0170 -0.0790 0.7525 0.2246 0.4230 -0.1062 0.5433 -0.2370 0.4217 -0.3271 0.2221S miR-7975 0.3303 0.0211 -0.0807 0.7525 0.2679 0.3311 -0.3069 0.0746 0.0694 0.8626 -0.1795 0.3767S miR-4454 0.2817 0.0537 -0.2229 0.3511 0.3318 0.1568 -0.2430 0.1901 0.2088 0.4217 -0.1678 0.4128Maternal HTN -0.2786 0.0546 1.0000 0.0000 0.0357 0.8909 0.0903 0.6007 -0.0586 0.8895 0.0945 0.6501L miR-187-5p 0.2512 0.0849 -0.2158 0.3511 -0.0950 0.6264 -0.0485 0.7276 0.0098 0.9963 -0.0826 0.6512S miR-7704 -0.2189 0.1365 0.0160 0.9672 -0.1798 0.4420 0.1891 0.2967 0.1970 0.4217 0.0638 0.7113Twin Gestation -0.1619 0.2853 0.0945 0.7525 -0.2342 0.4160 0.3051 0.0746 -0.2571 0.4217 1.0000 0.0000Infant Sex 0.1583 0.2859 0.0357 0.9154 1.0000 0.0000 -0.1578 0.3593 0.2857 0.4217 -0.2342 0.2221S miR-4784 -0.1560 0.2859 0.3193 0.1536 -0.1354 0.4750 -0.0629 0.6815 -0.0271 0.9947 0.2999 0.2221L miR-1200 0.1524 0.2889 -0.1556 0.5415 0.1692 0.4420 0.0611 0.6815 0.1679 0.4750 -0.2184 0.2321Maternal Ethnicity 0.0458 0.7657 -0.0586 0.8553 0.2857 0.2989 -0.0878 0.6007 1.0000 0.0000 -0.2571 0.2221S miR-4294 -0.0161 0.9078 0.1726 0.5384 -0.0054 0.9689 0.0786 0.6293 0.2256 0.4217 0.0034 0.9807 Significant Pearsons correlations are highlighted in pink. Abbreviations: Hypertension (HTN), Skim fraction (S), Lipid fraction (L), Benjamini Hochberg false discovery rate (FDR)
Supplementary Table S8. Eighteen miRNAs showed nominal differences between lipid fractions of foremilk and hindmilk tMBM, but none survived multiple testing correction.
p.value -Log10(p) FDRhsa-miR-769-3p 0.004629 2.3345 1hsa-miR-3675-5p 0.005083 2.2939 1hsa-miR-6850-3p 0.008625 2.0642 1hsa-miR-6809-5p 0.015606 1.8067 1hsa-miR-181d-5p 0.022741 1.6432 1hsa-miR-3943 0.022741 1.6432 1hsa-miR-487a-3p 0.028859 1.5397 1hsa-miR-296-5p 0.033507 1.4749 1hsa-miR-6742-5p 0.036343 1.4396 1hsa-miR-210-3p 0.037418 1.4269 1hsa-miR-203b-3p 0.03918 1.4069 1hsa-miR-6090 0.042152 1.3752 1hsa-miR-4433a-3p 0.043879 1.3577 1hsa-miR-4433b-5p 0.043879 1.3577 1hsa-miR-6502-5p 0.043879 1.3577 1hsa-miR-3917 0.045368 1.3432 1hsa-miR-3687 0.048844 1.3112 1hsa-miR-6756-5p 0.048844 1.3112 1