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Proposed Technical Approach: New effort

We propose to develop a series of molecular “Nantennas" (nanometer sized antennas) which can be dispersed in various forms and tracked by specific sensors. Molecular biotechnology enables us to design and create protein residues coupled to rare earth metals capable of receiving and transmitting weak, yet detectable, signature signals. We will develop nanoparticle devices and sensor technology to track the movement/presence of a tagged person or object.

Task 1: Design Nantenna Nanoparticles, metallo-protein coupled antennas, which can be resonated with an external signals.

Task 2: Create sensors for remote tracking of particles.

Task 3: Establish protocols for covert tagging of specific individuals or objects.

Operational Capability to be Provided:

Tracking suspected terrorists and predicting their potential behavior requires covert personnel activity monitoring and evaluation.

The development of Nantenna Nanoparticles, antenna-like molecules coupled to nanometer sized metallic particles designed to resonate at specific frequencies, provides a method of tagging and locating selected persons at a distance.

Based on established transmitter/receiver nano-technology, Nantennas can be applied to a target covertly via “dusting” and subsequently tracked by sensors tuned to secondary Nantenna emitted signals.

BAA Number: --------

Mission Area: Terrorist Behavior and Actions Predictions Technology

Requirement Number: -MINDTEL-100

Proposal Title: Nantenna Nanoparticles – Covert Personnel Tagging

MINDTEL, LLC. 11/01/2001

Rough Order of Magnitude Cost and Schedule:

Task 1 period of performance is 4 months, Tasks 2 and 3 begin after completion of Task 1 for a period of 8 months.

* Total performance period is 12 months

Task 1 ROM cost of $250,000

Task 2 + 3 ROM cost of $1,000,000

* Total cost is $1,250,000

Deliverables:

1. Nantenna nanoparticles in powder form.

2. Tracking device with remote sensing capabilities.

3. Data deliverables: monthly status report, final report, test plans, test reports, specifications, computer program end items, user’s manual, drawings, transition plan.

Corporate Information:

MindTel, LLC., Dave Warner, M.D., Ph.D. - P.O. BOX 8995 - Rancho Santa Fe, CA. 92067, (858) 759-8808 - email: davew@well.com

Nantenna Nano-particles

Tag and track

Operational Capability to be Provided:

Micro-sized sound and temperature monitoring devices can be distributed in and around high risk agricultural communities and provide Early Warnings of crop related terrorist activities. These chip-based devices will automatically correlate Chirp Rate and Temperature and when a critical parameter is violated, an emitted radio signal with GPS embedded information will allow localization and investigation of the monitored area.

If a cricket is heard to chirp 110 times per minute, the temperature is approximately 17.3 °C. If the chirp rate (CR) deviates from the temperature predicted rate (TPR), an anomaly in the environment has occurred and this will signal further investigation of the monitored area.

This system is based on the insect’s health. Chemical, low level (dirty bomb) radiation, and various bacterial and viral agents cause an appreciable difference in activity. This difference is then utilized as the signal parameter which alerts sensors to a potential threat.

BAA Number: 02-Q-4655

Mission Area: Early Warning Devices

Requirement Number: R-301 / ATL-301-MINDTEL-022-QC

Proposal Title: Agricultural Terrorist Attack Early Warning System: Organism-Based Sound Pattern Monitoring

MINDTEL, LLC.

11/01/2001

ATL-301-MINDTEL-022-QC

Rough Order of Magnitude Cost and Schedule:

Task 1 period of performance is 4 months, Tasks 2 - 4 begin after completion of Task 1 for a period of 8 months.

* Total performance period is 12 months

Task 1 ROM cost of $250,000

Task 2 – 4 ROM cost of $1,000,000

* Total cost is $1,250,000

Deliverables:

1. Integrated and miniaturized Chirp/Temperature Sensing Device with GPS Radio Frequency emitter.

2. Portable Radio Transmission receiving module with GPS coordinate display.

3. Data deliverables: monthly status report, final report, test plans, test reports, specifications, computer program end items, user’s manual, drawings, transition plan.

Corporate Information:

MindTel, LLC., Bill Rojas, Ph.D. – P.O. BOX 8995 - Rancho Santa Fe, CA. 92067, (858) 759-8808 - email: billrojas@hotmail.com

billrojas@mindtel.com

Proposed Technical Approach: New effort

Our approach interprets naturally occurring organism-based sound patterns which can yield an early warning to agricultural Chemical, Nuclear and Bio-attacks. Scientific proof exists for predicting temperature by counting male “Cricket Chirps”. These insect stridulation (specialized front-wing rubbing) sound patterns are based on “Arrhenius” chemical reaction rates and ambient temperature. For the Snowy Tree Cricket (Oecanthus fultoni) degrees Celsius is the number of chirps in 7 seconds plus 5, degrees Fahrenheit is the number of chirps in 13 seconds plus 40.

Task 1 - We will investigate specific modulation of emitted sound patterns based on Insect and other Organism exposure to various low level nuclear, chemical and biological toxins.

Task 2 – Integrate: species specific Sound Wave Form Detection and Analysis, Ambient Temperature Analysis, GPS – Global Position Sensing, Radio Transmitter and Solar Power Supply.

Task 3 – Component miniaturization and weather proof enclosure.

Task 4 – Portable monitoring module able to receive radio transmissions and display embedded GPS signal.

Concept 1: Archangel EnsembleMulti-Purpose Air Mobility System

Lockheed Martin Tactical Aircraft Systems02 June, 1999

Archangel Ensemble VersatilityMulti-Purpose Air Mobility System..Manned & Unmanned SOF Elements

Lockheed Martin Tactical Aircraft Systems02 June, 1999

Proposed Technical Approach: New effort

Our approach uses the genetic transfer abilities of electroporation to transfect severed limb region cells with DNA recombinant plasmids that may stimulate regeneration. Short electro-magnetic pulses are able to produce small pores in the membranes of in vivo cells and introduce mimicry genes into the nucleus, producing proteins within 24 hours of treatment.

Urodele cells dedifferentiate in the blastema, reverting to an embryonic state and interacting with FGF and various proteins from the AER. We can transfect a plasmid cocktail with TERT, p53 and Shh genes directly into the severed region (stump) of our subject. With telomeres extended and Shh signaling, the cells may be tricked to begin the re-growth process.

Our experiments have shown that transfected proteins are expressed post-electroporation for up to 6 months or more, allowing time for possible full limb replacement.

Task 1 – DNA Plasmid: ligated hTERT, p53 and Shh (x copies).

Task 2 – Design severed limb region electroporation protocol.

Task 3 – In vivo testing: mouse, pig, human.

BAA Number: Unsolicited Proposal

Mission Area: Persistence in Combat

Requirement Number: MINDTEL-01-QC – Phase I

Proposal Title: Electroporation and Severed Limb Regeneration Experiments

MINDTEL, LLC. 09/01/2002

Rough Order of Magnitude Cost and Schedule:

Task 1 period of performance is 3 months, Tasks 2 and 3 begin after completion of Task 1 for a period of 6 months.

* Total performance period is 9 months

Task 1 ROM cost of $33,000

Task 2 + 3 ROM cost of $66,000

* Total cost is $99,000

Deliverables: Phase I Feasibility Study -

1. Electro-Pulse Generator: Electroporator + Electrodes

2. Severed Limb Region (stump) Electroporation Protocol

3. Gene Product – Plasmid ligated to TERT, p53, Shh, etc.

4. Data deliverables: monthly status report, final report, test plans, test reports, specifications, computer program end items, user’s manual, drawings, transition plan.

Corporate Information:

MindTel, LLC., Bill Rojas, Ph.D. - P.O. BOX 8995 - Rancho Santa Fe, CA. 92067, (252) 258-1366 - email: billrojas@mindtel.com

24 hours Post-Electroporation: GFP expressing:Operational Capability to be Provided:

Severed Limb Regeneration – Phase I Feasibility Study

Electroporation of AER (Apical Ectodermal Ridge) Mimicry Plasmids

AER mimicry plasmids electroporated directly into the severed limb region to induce cellular dedifferentiation and regeneration. Re-growth is preserved in Urodela (Axolotl salamander family) with full regenerative capabilities well into adulthood. Genes that could be of specific benefit in mimicing this process with humans will be investigated:

1) TERT – Telomerase Reverse Transcriptase: Codes for enzyme that extends telomeres and perhaps induce embryonic stage. http://www.genlink.wustl.edu/teldb/pteldb/pfile/hTERT.html

2) p53 – This gene codes for protein that inhibits cells with damaged DNA from duplicating, preventing the development of tumors. http://www.ncbi.nlm.nih.gov/disease/p53.html

3) Shh, Sonic Hedgehog – This gene is involved in the formation of the AER and ZPA, Zone of Polarizing Activity secretes RA (Retinoic Acid). Stimulated by FGF (Fibroblast Growth Factors) secretion from the AER and Progressive Zone (PZ). http://www.life.uiuc.edu/csb/faculty/cameron.html

4) Msx-2 and keratin 1 as well as specific members of Hox genes family. Implicated in mammalian regeneration with mouse models. The Scientist 13[11]:1, May. 24, 1999

Proposed Technical Approach:

Summary:

Determining from a population of 300 million those planning to conduct terrorist activities is of paramount concern in the United States. The ability to gain insight into the mental activities of a suspected individual can be achieved with EEG monitoring equipment and “Brain Fingerprinting”, (Farwell, 2001). This method, only applicable with the full cooperation of the target, detects electrical voltages from the scalp then analyses for novel (p300) and familiar (n400) responses to questions.

Task 1 - Our approach extends the reception capabilities of the electrodes by utilizing the natural ability of a human body to monitor another human while in close proximity.

Task 2 - We are investigating interactive brainwave distances from 1 to 10 feet. Further research is needed to determine any possible field potential for law enforcement or military applications.

Task 3 – The ability to distinguish a specific individual within a crowd is achieved by “painting” the selected target with a pulsed laser light (TBD) and establishing a pre-selected carrier frequency signature for that individual.

The Human Electrode paradigm utilizes the complete physiological acquisition and processing capabilities of the body to increase the signal to noise (s/n) ratio in EEG analysis. Our method begins by attaching conventional brainwave monitoring electrodes to two human subjects. Subject 1 is the Emitter and will be interrogated by a third person. Subject 2 is the Receiver or Human Electrode and is sensory deprived with a blindfold and silent head-phones so as not to elicit a personal response to the stimulus questions. While the 3rd person interrogates Subject 1 with a predetermined series of words designed to elicit novel or familiar evoked potentials; Subject 2 is monitored for a synchronous resonant EEG response of p300 or n400.

Efficacy of Brain Fingerprinting:Studies completed at a US intelligence agency proved that Farwell Brain Fingerprinting could accurately and reliably detect individuals possessing information regarding mock crimes and real-life activities, including a small number of actual major crimes. In Experiment 3 at the agency, the information detected was relevant to a mock espionage scenario enacted by some of the subjects, and the stimuli that elicited the brain responses were relevant pictures presented on a computer screen. In Experiment 4 at the agency, which used visually presented words and phrases as stimuli, the information detected was relevant to real-life events, including two felony crimes.

BAA Number: 02-Q-4655

Mission Area: Combating Terrorism – Terrorist Behavior and Actions Predictions Technology

Requirement Number: R-108/

Proposal Title: The Human Electrode – Covert Distant Brainwave Monitoring

MindTel, LLC.

Oct. 28, 2001

Rough Order of Magnitude Cost and Schedule:

Task 1 period of performance is 4 months, Tasks 2 and 3 begin after completion of Task 1 for a period of 8 months.

* Total performance period is 12 months

Task 1 ROM cost of $250,000

Task 2 + 3 ROM cost of $1,000,000

* Total cost is $1,250,000

Deliverables:

1. Data deliverables: monthly status report, final report, test plans, test reports, specifications, computer program end items, user’s manual, drawings, transition plan.

Corporate Information:

MindTel, LLC., Dave Warner, MD, PhD. PO BOX 8995 Rancho Santa Fe, CA. 92067, (858) 756-1717, davew@well.com

Emitter ----- Brain Fingerprinting – Brainwave Science ------ Receiver

BAA Number: -------

Mission Area: Counter Terrorism Technologies

Requirement Number: MINDTEL-QC

Proposal Title: Cultural Intelligence and Threat Detection

MINDTEL, LLC.

11/01/2001

SAN DIEGO CYBERARIUM – Portal to America

Cultural Intelligence:

• Comprehend threat potential:

• Assess counter-activity response:

• Actuate delivery of safeguards:

• Acute and Chronic situational awareness:

Corporate Information:

MindTel, LLC., Dave Warner, M.D., Ph.D. – P.O. BOX 8995 - Rancho Santa Fe, CA. 92067, (858) 759-8808 - email: davew@well.com

Sentinels for Homeland Defense:

Population Concentrations/Distributions:

The population concentrations and distributions of 300 million inhabitants residing within the 3,066 counties in the US can be updated daily.

Each county will have at least one representative who will monitor local conditions and update pertinent information to a website.

Acres of Harvested Cropland:

Agricultural, livestock, and utilities will incorporate low cost sensing devices which will update continuous video, audio, chemical or biological environmental monitoring.