MECHANISMS OF

LYMPHOCYTE ACTIVATION

AND IMMUNE REGULATION X

Innate Immunity

Sudhir Gupta

William E. Paul

Ralph Steinman

1. TIR DOMAIN-CONTAINING ADAPTORS REGULATE TL RSIGNALING PATHWAY SMasahiro Yamamoto and Shizuo Akira 1

2. TOLL-LIKE RECEPTORS : LINKING INNATE ANDADAPTIVE IMMUNIT YChandrashekhar Pasare and Ruslan Medzhitov 1 1

3. ACTIVATION OF INSECT AND VERTEBRATE TOLL SIGNALING :FROM ENDOGENOUS CYTOKINE LIGAND TO DIREC TRECOGNITION OF PATHOGEN PATTERN SNicholas J . Gay, Alexander N . R . Weber and Monique Gangloff 1 9

4. GENETIC ANALYSIS OF INNATE IMMUNITY: IDENTIFICATIONAND FUNCTION OF THE TIR ADAPTER PROTEIN SBruce Beutler, Kasper Hoebe, Philippe George], Koichi Tabeta, and Xin Du 2 9

5. NF-KB, AN EVOLUTIONARILY CONSERVED MEDIATOR O FIMMUNE AND INFLAMMATORY RESPONSESChangchun Xiao and Sankar Ghosh 4 1

6. INFLUENCE OF KIR DIVERSITY ON HUMAN IMMUNIT YPeter Parham 4 7

7. NKG2D IN INNATE AND ADAPTIVE IMMUNIT YLewis L . Lanier 5 1

8. SPECIFIC AND NON-SPECIFIC NATURAL KILLER CEL LRESPONSES TO VIRAL INFECTIO NWayne M . Yokoyama 57

9. ANTIGEN PROCESSING AND PRESENTATION BY DENDRITI CCELLS: CELL BIOLOGICAL MECHANISM SIra Mellman 6 3

10. HUMAN THYMIC STROMAL LYMPHOPOIETIN TRIGGER SDENDRITIC CELL-MEDIATED ALLERGIC INFLAMMATIO NAND CD4+ T CELL HOMEOSTATIC EXPANSIO NNorihiko Watanabe, Vassili Soumelis, and Yong-Jun Liu 6 9

11. ROLE OF TRAF6 IN THE IMMUNE SYSTEMYong won Choi 77

12. THE INNATE FUNCTIONS OF DENDRITIC CELLS INPERIPHERAL LYMPHOID TISSUE SRalph M. Steinman, Laura Bonifaz, Shin-ichiro Fujii, Kang Liu,David Bonnyay, Sayuri Yamazaki, Maggi Pack, Daniel Hawiger ,Tomonori Iyoda, Kayo Inaba, and Michel C . Nussenzweig 8 3

13. THE MANNOSE-BINDING LECTIN : AN INFECTIONSUSCEPTIBILITY GEN ER . Alan Ezekowitz, Lei Shi, lain Fraser, and Kazue Takahashi 9 9

14. IMMUNOTHERAPY VIA DENDRITIC CELL SA. Karolina Palucka, Beatrice Laupeze, Caroline. Aspord, Hiroaki Saito ,Gaetan Jego, Joseph Fay, Sophie Paczesny, Virginia Pascual andJacques Banchereau 10 5

15. ONTOGENY OF LANGERHANS CELLS AND GRAF TVERSUS HOST DISEASEMiriam Merad 11 5

16. ROLE OF THE CD19 AND CD21/35 RECEPTOR COMPLEX I NINNATE IMMUNITY, HOST DEFENSE AND AUTOIMMUNIT YKaren M . Haas and Thomas F. Tedder 12 5

17. ROLE OF COMPLEMENT RECEPTOR 2 IN THE PATHOGENESI SOF SYSTEMIC LUPUS ERYTHEMATOSU SSusan A . Boackle 14 1

18. COMPLEMENT REGULATION DURING PREGNANCYHector Molina 149

INDEX 157