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Mechanism of Action of Aspirin
Carlo Patrono, et al, N Engl J Med 2005;353:2373-83
Maximal Capacity of Human Platelets to Synthesize Thromboxane B2 (Panel A), Rate of TXB2 Production
in Healthy Subjects (Panel B), and Nonlinear Relationship between the Inhibition of Platelet
Cyclooxygenase Activity and TXB2 Biosynthesis in Vivo (Panel C)
Carlo Patrono, et al, N Engl J Med 2005;353:2373-83
Absolute Effects of Antiplatelet Therapy with Aspirin on the Risk of Vascular Events (Nonfatal Myocardial Infarction, Nonfatal Stroke, or Death from Vascular
Causes) in Five Groups of High-Risk Patients
Carlo Patrono, et al, N Engl J Med 2005;353:2373-83
High-Risk Disorders for Which Aspirin Has Been Shown
to Be Effective and Lowest Effective Daily Dose
Carlo Patrono, et al, N Engl J Med 2005;353:2373-83
Benefits and Risks of Low-Dose Aspirin in Primary-Prevention Trials
Carlo Patrono, et al, N Engl J Med 2005;353:2373-83
Estimated Rates of Upper Gastrointestinal Complications in Men, According to Age and the
Presence or Absence of a History of Such Complications and Regular Treatment with Low-
Dose Aspirin
Carlo Patrono, et al, N Engl J Med 2005;353:2373-83