Mechanism of Action of Aspirin

Carlo Patrono, et al, N Engl J Med 2005;353:2373-83

Maximal Capacity of Human Platelets to Synthesize Thromboxane B2 (Panel A), Rate of TXB2 Production

in Healthy Subjects (Panel B), and Nonlinear Relationship between the Inhibition of Platelet

Cyclooxygenase Activity and TXB2 Biosynthesis in Vivo (Panel C)

Carlo Patrono, et al, N Engl J Med 2005;353:2373-83

Absolute Effects of Antiplatelet Therapy with Aspirin on the Risk of Vascular Events (Nonfatal Myocardial Infarction, Nonfatal Stroke, or Death from Vascular

Causes) in Five Groups of High-Risk Patients

Carlo Patrono, et al, N Engl J Med 2005;353:2373-83

High-Risk Disorders for Which Aspirin Has Been Shown

to Be Effective and Lowest Effective Daily Dose

Carlo Patrono, et al, N Engl J Med 2005;353:2373-83

Benefits and Risks of Low-Dose Aspirin in Primary-Prevention Trials

Carlo Patrono, et al, N Engl J Med 2005;353:2373-83

Estimated Rates of Upper Gastrointestinal Complications in Men, According to Age and the

Presence or Absence of a History of Such Complications and Regular Treatment with Low-

Dose Aspirin

Carlo Patrono, et al, N Engl J Med 2005;353:2373-83