MD/PhD Program “Molecular Medicine“ - MH … · approach, including ... The MD/PhD Program “Molecular Medicine“ started in winter semester 2000/01. Since 01.01.2002 ... “non

MD/PhD Program “Molecular Medicine“

Hannover Medical School

Report 2003

MD/PhD Program “Molecular Medicine“

Hannover Medical School (MHH)

Responsible persons Univ. Prof. Dr. Reinhold E. Schmidt Chairman MD/PhD Program Carl-Neuberg Str. 1 30625 Hannover Tel: 0511-532-6656 [email protected] MD/PhD commission:

Prof. Dr. E. Ungewickell, Prof. Dr. A. Gossler, Prof. Dr. J. Schmidtke, Prof.’in Dr. B. Schlegelberger, Prof. Dr. C. Klein, Prof. Dr. R. Förster, HD Dr. B. Sodeik, PD Dr. T. Tschernig, Dr. S. Münte, Dr. F. Bahlmann, Dr. C. Nassenstein, Dr. E. Hesse Dr. Susanne Kruse, Marlies Daniel MD/PhD Office

OE 9117 Carl-Neuberg Str. 1 30625 Hannover Tel. 0511-532-6011 [email protected] [email protected] Internet: www.mh-hannover.de/studium/phd

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President of Hannover Medical School

Hannover Medical School is proud to offer the first PhD program in Germany to be accreditated according to European standards. The main issue of this international postgraduate program is to train young German medical doctors as well as students from life sciences and to attract participants from abroad. The Medical School Hannover is making an important effort to get a higher degree of internationalization. Hannover Medical School is the youngest Medical School in Germany, located on the Campus Roderbruch, which is in the eastern part of Hannover. The main scientific topics are transplantation research, research in mucosal immunity, in infectious diseases and in immunity, in cell biology and specially in stem cell research. Most of all scientific activities are organized in a multidisciplinary approach, including preclinical and clinical departments. Many thanks to the organizers, lecturers and supervisors of this program. I hope that the best young scientists from everywhere will be interested in coming to Hannover. Professor Dr. Horst v. der Hardt President of the Hannover Medical School, 03/99-03/04

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Chairman

The MD/PhD program „Molecular Medicine“ was established in autumn 2000. Last year, the first students did successfully graduate with outstanding achievements. Our program has meanwhile become one of the leading MD/PhD programs in Germany due to excellent interdisciplinary cooperation between the Hannover Medical School, the University and the School of Veterinary Medicine Hannover due to the support of the International Promotion Program (IPP) by DAAD and DFG. It is also the first German PhD program which has been accreditated according to European standards (modules ECTS). There is a good ratio between medical students and students from life sciences as well as between German and foreign students. This program attracts great national and international interest. Additionally, the MD/PhD porgram is the basis for the Hannover Biomedical Research School founded in 2003. Many thanks to everyone who has supported this new MD/PhD program, especially to those students who will determine the future excellence of the program.

Reinhold E. Schmidt, MD Professor of Medicine and Immunolgy

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We express our thanks to our sponsors: “Friends of MHH”

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Table of Contents

I. Current Status, Problems and Prospects ________________________ 15

1. Current Status ___________________________________________________________________ 15 2. Common Rules ___________________________________________________________________ 17 3. Cooperation with International Institutes_____________________________________________ 17 4. Measures for Implementation_______________________________________________________ 19

II. Measures and Results _______________________________________ 19

1. Personnel _______________________________________________________________________ 19 1.1. Scientific collaborators and administrative personnel__________________________________________ 19 1.2. Tutors ______________________________________________________________________________ 20

2. Language courses_________________________________________________________________ 20 3. Social Activities __________________________________________________________________ 20 4. Organization of Educational Material________________________________________________ 21 5. Marketing Measures ______________________________________________________________ 21 6. Guest Lectures and additional colloquia ______________________________________________ 22 7. Travel __________________________________________________________________________ 23 8. Visits abroad by the graduate students _______________________________________________ 23

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I. Current Status, Problems and Prospects

1. Current Status

At the moment there are 58 students in the program [23 women und 35 men; 35 international and 23

Germans; 34 medical students (incl. veterinary students) and 24 scientists]. The international students

come from Argentina (1), China (3), Columbia (1), Ethiopia (1), Georgia (1), Hungary (1), India (19),

Indonesia (2), Japan (1), Slovakia (1), Syria (1), the Netherlands (1), Turkey (1) and Ukraine (1). The

students are either financed by the corresponding departments or by scholarships (DAAD;

“Gesellschaft der Freunde der MHH“; Winkra Energie etc.).

Concerning selection of the new students, a 3-step level procedure was introduced in 2002. It consists

of: 1. preselection by the PhD commission, 2. a written test in the individual home countries, 3. an

interview (in 2003 in Hannover and New Delhi and Hyderabad, India). In 2002 an extensive

application form was developed, which as further improved in 2003.

The selection of the applicants is based on qualification only. The accepted candidates are supposed to

choose a department and a research project themselves. This means that there can be bottle-necks

regarding the guarantee of the financing of the students. For this reason scholarships were applied for

with e.g. the EU - Marie Curie Programm.

Students work on a 3-year research project in one of the departments of the MHH or at cooperating

institutes (see list of students). In addition, there is an obligation program of teaching consisting of

seminars and tutorials (see list of lecturers). In the first year basics and methodics of biology and

medicine are taught. During the second academic year, focus lies more on current research projects

(applied aspects). Since 2003, four main foci have been established: Immunology; Infection; Oncology

and Differentiation; Genetics and Cell Biology (see Curriculum, Fig. 2). Besides an extensive English

curriculum, guest seminars, scientific colloquia, discussions with the supervisors and technical

practical courses took place. Most important are the so-called “soft skills“ as well as seminars about

“Ethics“ (Prof. Schmidtke), “Animal Experiments“ (Prof. Hedrich), “Scientific Writing“ (Dr. Kruse),

“Presentation techniques” (Prof. Dierks) etc. The students keep book about all seminars. At the end of

every semester an evaluation of the educational programs and lecturers is performed.

After 18 months, students give an oral intermediate exam in the respective main subject and the

subject of the co-supervisor (presentation and discussion of a research paper). After 3 years the final

exam takes place in form of a public disputation. In 2003, six MD/PhD students (Massoumeh Attaran,

Yasmin Dulkys, Veit Erpenbeck, Gernot Sellge, Julia Skokova, Andreas Tiede) suceessfully finished

the program. 8

The ECTS System was introduced (credit points = cp; see Fig. 1). The program was accreditated

according to European standards by ZEvA on December 9th, 2003.

Figure 1. Study Structure MD/PhD Program “Molecular Medicine“

The current structure of the Curriculum is as follows:

Figure 2. Curriculum 2003/4

3-year PhD project work (125 cp) Annual presentation in department (3x; 10 cp) Journal club (3x; 3 cp) Public annual presentation/project report (3x; 10 cp) Talk/presentation on international congress (2 cp)

Basics (seminar and tutorial; 3 h per week; 8 cp)

Year 1 Year 2 Year 3

Interdisciplinary seminars/courses (60 h; 6 cp) Project-orientated seminars/courses (80 h; 8 cp)

PHD thesis

and Final exam Complex and clinical

systems (seminar and tutorial; 3 h per week; 8 cp)

Intermediate Exam after 18 month

1st year

In parallel: special in-depth seminars for medical students and students from life sciences, respectively

Basics in Molecular Medicine (Focus on Methods); Seminar Tuesday, 2h

Tutorial Thursday, 1h

Tutorial for the respective seminar on Tuesday

Christmas 1st sem. 2nd sem.

2nd year

1. Focus: Immunology

2. Focus: Genetics and Cell Biology

3. Focus: Infection

4. Focus: Differentiation and Oncology

or

or

4th sem. 3rd sem.

}

For all: Seminar Tuesday, 2h and Tutorial Thursday,

In September 2002, a nation-wide network of biomedically orientated PhD programs was established

by the MHH to which 11 different universities currently belong. In 2003, two meetings took place (in

Bonn). Discussions were going on about mutual aims, problems and cooperations. There will be a

further improvement of coordination of the selection procedures (exams and interviews).

2. Common Rules

On 15.12.99, a rule for the MD/PhD program was passed by the senate of Hannover Medical School.

This rule unites a regulations for studies and exams. On 12.02.02, the MD/PhD program received

authorization from the Lower Saxony Ministry for Science and Culture to alternatively award besides

the PhD title for scientists the title Dr. rer. nat. Such changes in the rules and adaption to the program

situation were passed by the senate on 04.06.02. On 11.02.04, the rules were adapted to the

suggestions by the committee of referees for accreditation and were overall updated. The PhD rules

consider all aims of the program.

3. Cooperation with International Institutes

Fortunately within the MHH there is an active exchange, i.e. participation of almost all scientifically

active departments in the MD/PhD program – whether by means of active organizing within the

MD/PhD commission, by supervising the MD/PhD students at the research laboratories or as lecturers

in the numerous educational programs. This goes for the basic scientific as well as for the clinically

orientated departments, for example: Biochemistry, Dermatology, Developmental Biologiy, Genetics,

Hematology, Hepatology and Gastroenterology, Heart and Thoracic Surgery, Immunology,

Microbiology, Nephrology, Neurology, Oncology, Pathology, Physiology, Rheumatology, Tumor

Biology, Visceral and Transplantation Surgery, Cell Biology etc. Therefore intensive cooperation

exists between collaborators (Post-docs etc.) from Graduate Colleges with the MD/PhD program.

Moreover, the “Graduate School” (Hannover Biomedical Research School) was founded in October

2003. There is close cooperation between the graduate and PhD programs of the School of Veterinary

Medicine Hannover, also concerning lecturers and students. Thanks to the scientists of the MHH there

is already intensive cooperation with European and internationally very well-known research institutes

(e.g. also by means of the European Graduate College “Pseudomonas: Pathogenicity and

Biotechnology“). Of course, the PhD students profit from this cooperation, too.

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A constant exchange and participation in education and research exists with the following institutes:

a) national:

• German Research Center for Biotechnology (GBF); Braunschweig

• School of Veterinary Medicine, Hannover

• Fraunhofer Institute for “Toxicology and Experimental Medicine”, Hannover

• Max Planck Institute for “Experimental Endocrinology“, Hannover

• Institute for “Animal Breeding”, Mariensee (FAL)

• Center for Stem Cell Research, Gatersleben

There is intensive cooperation with these national institutes as well as concerning education (lecturers)

and concerning research, i.e. making three year projects available or the function of scientists as co-

supervisors.

b) international (especially with):

• Cincinatti Children’s Hospital, Ohio, USA

With Prof. Dr. J. Köhl close cooperation. Exchange of scientists is planned.

• Scripps Research Institute, La Jolla, USA

Dr. Tanja Heller (student of 1. academic year) is spending two research years in La Jolla with the

Emmy Noether Program (DFG). An intensive scientific exchange results from this.

• Centre for DNA Fingerprinting (CDFD), Hyderabad, India

With Prof. Dr. S. Hasnain there has been intensive contact since 2002 (see guest lecturer and trip to

India). The establishment of a mutual “summer school“ is planned (application at Volkswagen

Foundation) and the exchange of scientists.

• Centenary Institute, Sydney, Australia

Marc H. Dahlke (Student of the 2. academic year) is currently spending one research year in

Sydney.

c.) Economy/Industry (especially with):

IPF PharmaCeuticals GmbH, Hannover

Industry excursions (e.g. Schering AG, Berlin).

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4. Measures for Implementation

The MHH has guaranteed to continue financial support of the MD/PhD program after discontinuation

of the support by the DAAD/DFG (after 5 years). The MD/PhD program will play a key role in all

respects (scientific, organization) in Hannover Biomedical Research School. The establishment of the

Graduate School will be considered in the future budget.

The accreditation (see above) implements the program.

II. Measures and Results

The MD/PhD Program “Molecular Medicine“ started in winter semester 2000/01. Since 01.01.2002

the program is supported by the DAAD/DFG by means of the “International Promotion Program”

(IPP).

1. Personnel

Within the IPP the posts for a scientific coordinator (full time) and funds for assistant students (see

“non scientific care”; 10 hours/week) have been granted.

1.1. Scientific collaborators and administrative personnel

Since 01.05.2002 Dr. Susanne Kruse has been working on the program as scientific coordinator. She

is a graduated biologist and, therefore, most competent for the sector “Molecular Medicine”. She has

various tasks; she is responsible for the total coordination and organization of the MD/PhD program,

e.g.

• Consultation of the PhD students and applicants

• Organization and coordination of the application procedure

• Cooperation with the PhD commission

• Processing of the PhD commission meetings

• Contact to supervisors and lecturers of the Medical School and cooperating institutes

• Public relations (articles, homepage design etc.)

• Marketing (flyers, poster, advertisements etc.)

• Fund raising (incl. sponsors); applications (EU, „Stifterverband“,BMBF etc.)

• Planing of the curriculum

• Organization of workshops/seminars

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• Presentation of the seminar “Scientific Writing“

• Evaluation of seminars and tutorials

• Preparation of exams and coordination

• Organization of the inauguration, non scientific care and social activities

• Contact to DAAD and other PhD programs (esp. MD/PhD Network)

• Organization und application for accreditation

• Administration of the budget

• Instruction of the person in charge (Mrs. Daniel), the German teacher (Mrs. Marotz)

and both assistant students (see below!)

Mrs. Marlies Daniel works at the PhD Office (full time) as person in charge/correspondant. Her

position is financed by the Hannover Medical School.

Mrs. Daniel supports Dr. Kruse with the coordination und organization of the MD/PhD program. She

is responsible for the total correspondence, telephone calls, organization of the application procedure,

taking care of the students (esp. during the training period: organization of accommodation, banks,

insurance etc.), statistics etc.

1.2. Tutors

Rebecca Bieber und Julia Fraedrich have been employed as assistant students for each 5 hours/week

since 01.07.2002. Both tutors especially take care of the MD/PhD students in close cooperation with

the “International Office” (concerning culture, geography, history and institutions) and help at German

authorities.

2. Language courses

Mrs. Petra Marotz has been employed as the German teacher since 01.10.2002 (hourly basis) with a

lectureship. She teaches the foreign PhD students in two courses à 2 hours/week. This concerns a

course for beginners and an advanced course (1 year experience). A total of 15 MD/PhD students

participate in the courses.

3. Social Activities

• On 31.05.03, a tour to Papenburg took place, main organization of the “International office”.

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• On 11.07.03, 20 MD/PhD students visited the company Schering AG in Berlin.

• On 17.07.03, the summer term was closed by a grill party in the courtyard of building I1. Lots of

students, lecturers and supervisors came.

• From 23. – 24.08.03, a trip to the North Sea for all international students was organized by the

DFA (Deutscher Famulanten Austausch).

• The orientation weeks (from October 1st), which were organized for the first time, were supported

by the “WIN” (welcome in Niedersachsen) program of Lower Saxony.

• The opening of term was celebrated on 14.10.03. All students, lecturers, supervisors, the head of

MHH as well as a large number of invited guests came. Invited speaker: Dr. Josef Lange (State

secretary of the Ministery of Research). Musical introduction: Pure Desmond (Hargassner).

• On 07.11.03, the six MD/PhD final exams were celebrated. Invited speaker: Prof. Dr. D.

McConnell (Trinity College, Dublin, Ireland).

• On 21.11.03, 17 MD/PhD students visited the town hall of Hannover, invited by Ingrid Lange

(deputy major).

• On 06.12.03, a bus excursion to Bremen took place together with the “International Office”. We

had a guided tour and a visit to the art museum (Paul Klee exhibition).

• On 18.12.03, an international Christmas party was celebrated with all MD/PhD students, lecturers

and supervisors.

4. Organization of Educational Material

For the seminars/lectures another “Beamer” was bought. The MD/PhD office moved to building I4

(level 1) in November. We have two offices and two seminar rooms now. Another PC and colour laser

printer were bought. All equipment was added to the inventory by the Medical School. Four different

basic textbooks (Immunology; Genetics; Cell Biology; Developmental Biology) were bought and are

available now for all MD/PhD students in our cabin in the library.

5. Marketing Measures

• For marketing uses, flyer and poster were created and printed by the agency HzweiS. These were

distributed on meetings, congresses, within MHH and other universities.

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• A large number of ads were published in Nature, die Zeit, Science, HAZ, MAI Journal, SZ,

Laborjournal etc.). The resonance was enourmous (300 applications).

• Within MHH, poster are put up to inform employees and students of events (info meetings,

ceremonies etc.), printed by the “Forschungswerkstätten”.

• A year book 2002 was printed, supported by sponsors.

• On 15.04.03, an info meeting on the MD/PhD program was organized for scientists and students.

• Because of the accreditation, the MD/PhD program serves as a model and advisor for lots of other

programs.

6. Guest Lectures and additional colloquia

• On 31.01.03, the seminar “Scientific writing” was given by S. Kruse at MHH.

• From 21. – 22.02.03, Prof. Schmidtke held his seminar “Ethics and Genetics” at MHH.

• on 28.04.03 and 05.05.03, Prof. Hedrich and colleagues gave a course on “Animal Experiments” at

MHH.

• From 04. – 05.04.03, the annual presentation workshop took place at the festival hall of the

Stephansstift Hannover. All students had to present and openly discuss their projects with the other

students, lecturers and supervisors. Separate student and supervisor meetings were organized. On

Friday, an international evening took place.

• On 16.05.03, a seminar organized by the company “Applied Biosystems” on “Gene expression and

SNP genotyping for human and mouse – Real-time PCR possibilities today and tomorrow” was

performed.

• The on-site evaluation by the accreditation committee was done on 24.06.03.

• Altogether 44 applicants were invited to interviews in Hannover, New Delhi (India; DAAD office)

and Hyderabad (India; CDFD) beginning of Juli 2003. The candidates had to give a short

presentation on a past or future project. In Hannover, the applicants were accomodated in the

“Sleep-In” guest house.

• From 14. – 15.07.03, the workshop on “Presentation techniques” took place at MHH (Frau PD Dr.

Dierks). The aim was to train students for giving annual presentations, conference talks etc.

• On 07.11.03, the first six final exams were sucessfully performed (public disputation, in English).

External referees were invited (Daeron, Paris; v. Weizäcker, Freiburg; Maurer, Mainz; Schröder,

Kiel; Virchow, Rostock; Grez, Frankfurt). Invited speaker: Prof. Dr. D. McConnell (Dublin,

Ireland). Musical introduction/ending: Herr Neuhäuser.

7. Travel

• Claudia Karacsonyi was granted a travel support for a congress in Göttingen (March 2003).

• From 05. – 07.05.03, Dr. S. Kruse and Prof. Dr. R.E. Schmidt were attending the “Jahrestagung der

DAAD geförderten PHD Programme” in Bonn.

• From 30.06. – 04.07.03, the MD/PhD students Ferdinand Bahlmann, Veit Erpenbeck, Julia Freise,

Marcel Mala, Anika Meyerholz and Axel Schambach were attending the meeting with nobel prize

holders in Lindau.

• From 03. - 07.07.03, Dr. S. Kruse, Prof. Dr. R. E. Schmidt und Prof. Dr. C. Klein were traveling to

India to give interviews with 22 applicants in the DAAD office New Delhi and at CDFD,

Hyderabad. From these applicants, 8 were selected for the program. In Hyderabad, contacts with

Prof. Dr. S. Hasnain were tightened.

• From 19. - 20.09.03, Dr. S. Kruse visited the general meeting of the Swiss MD/PhD society in

Basel.

• On 26.09.03, Dr. S. Kruse attended the annual meeting of the “Deutsche Gesellschaft für

Immunologie” in Berlin.

• From 27. - 28.10.03, Dr. S. Kruse was invited to give a talk on “marketing on demand” on the

GATE Workshop “Internationales Hochschulmarketing” in Bonn.

• From 08. – 09.12.03, Dr. S. Kruse and Prof. Dr. R.E. Schmidt attended the annual meeting of the

DAAD programs (IPP) in Bonn.

8. Visits abroad by the graduate students

• For three PhD students travel costs to Hannover were supported (October 2003). The other

students were supported from the “WIN” program (see above).

• Overall, the MD/PhD students attended numerous meetings, congresses and short research stays

abroad. They were supported by the departments, DAAD, DFG (Emmy Noether) etc.

16

Year 2000

Tanja Heller

Nadine Landgraf

Masami Rudolph

EducationCollege/University:1992-2000 Hannover Medical School andFac. de med. Montpellier

Highest degree:MD (Dr. med.)

Major Subjects:Medicine

Projects/Research: Complement systemToll like receptors, signal transduction

Scholarships:Studienstiftung des Deutschen VolkesEmmy Noether Stipendium DFG

Scientific Interests and Goals:Mechanisms of innate immuntity

Hobbies and other interests:Music, Sports, Travel

Publications:Heller T, Hennecke M, Baumann U, Gessner JE, zu Vilsendorf AM, et al. J Immunol. 1999; 163(2):985-94Heller T, Gessner JE, Schmidt RE, Klos A, Bautsch W, Kohl J. J Immunol. 1999; 162(10):5657-61

First name:Tanja

Last name:Heller

Date of birth:25.04.1973

Country:Germany

E-mail:[email protected]

Supervisor:Prof. R.E. SchmidtClinical Immunology

EducationCollege/University:1994-2000 School of Veterinary Medicine Hannover

Highest degree:Veterinarian

Major Subjects:Molecular Biology, Veterinary Medicine

Projects/Research:Myosin Mutation 723 Arg->Gly as one reason for FHC. Investigation on molecular level.

First name:Nadine

Last name:Landgraf


Country:Germany


Supervisor:PD KraftMolecular and CellPhysiology

EducationCollege/University:1991-1997 Kyolin University1998-2000 Harvard Medical School

Highest degree: MD

Major Subjects:Molecular biology

Projects/Research:Molecular analysis of somatogenesis in mouse

Scientific Interests and Goals:Having own laboratory or biotechnology company

Hobbies and other interests:Swimming, Watching movies

Publications:Watabe-Rudolph M. Schlautmann N. Papaioannou VE. Gossler A. Mech Dev. 2002; 119:251-6.Watabe-Rudolph M. Rudolph KL. Averbeck T. Buhr T. Lenarz T. Stover T. Otol Neurotol. 2002; 23:793-8.

First name:Masami

Last name:Rudolph


Country:Japan

Email:[email protected]

Supervisor:Prof. GosslerMolecular Biology

Year 2001

Wahid Ansari

Ferdinand Bahlmann

Asha Balakrishna

Christian Bernreuther

Frank Bollig

Marc H. Dahlke

Meta Djojosubroto

Julia Freise

Christoph M. Happel

Vladimira Jakubcakova

Yijiang Li

Jian-Yun Liu

Tom Lüdde

Ebru Serinsöz

Frank Tacke

Matthewos Tessema

Sonja Werwitzke

EducationCollege/University:Aligarh Muslim University, Aligarh Panjab University, Chandigarh

Highest degree:M.Sc. in Biotechnology

Major Subjects:Molecular Biology and Immunology

Projects/Research:Role of Natural Killer Cells in HIV-1 Infection

Scholarships:DBT-Govt. Of India fellowship-M.Sc programmeCSIR-Govt. Of India Junior Research FellowshipSFB 566-Teilproject A2

Scientific Interests and Goals:Immunobiology and Molecular Pathogenesis of Infectious Diseases.

Hobbies and other interests:Cricket, Music and Travelling

First name:Abdul Wahid

Last name:Ansari


Country:India

E-mail: [email protected]

Supervisor:Prof. R E SchmidtDr. Hans HeikenClinical Immunology

EducationCollege/University:1994 – 2001 Hannover Medical School2000 – 2001 Tufts University, School of Medicine, Boston,

USA


Projects/Research:Endothelial Progenitor Cells in Kidney Disease

Scientific Interests and Goals:To transfer basic science from bench to bedside

Publications:Bahlmann F, Janssen U, Kohl J, Zwirner J, Haubitz M, Floege J A J KidneyDis 2000; 35:21-28.Schratzberger P, Walter DH, Rittig K, Bahlmann FH, Pola R, et al.. J ClinInvest 2001; 107:1083-1092.Ostendorf T, Kunter U, Grone HJ, Bahlmann F, Kawachi H, et al. J Am Soc Nephrol 2001; 12:909-918.Walter DH, Rittig K, Bahlmann FH, Kirchmair R, Silver M., et al.Circulation 2002; 105:3017-3024.

Woywodt A, Bahlmann FH, De Groot K, Haller H, Haubitz, M. NephrolDial Transplant 2002; 17:1728-1730Dahlke MH, Popp FC, Bahlmann FH, Aselmann H, Jager MD, Neipp M,Piso P, Klempnauer J, Schlitt HJ. J Hepatol. 2003;39:365-73.Bahlmann FH, DeGroot K, Duckert T, Niemczyk E, Bahlmann E, BoehmSM, Haller H, Fliser D. Kidney Int. 2003;64:1648-52.Bahlmann FH, De Groot K, Spandau JM, Landry AL, Hertel B, Duckert T,Boehm SM, Menne J, Haller H, Fliser D. Blood. 2004;103:921-6.Bahlmann FH, de Groot K, Haller H, Fliser D. Nephrol Dial Transplant.2004;19:20-2.Bahlmann FH, deGroot, K., Sowa, J., Hertel, B.,Menne, J., Haller,H.,Fliser, D. Kidney Int. In pressBahlmann FH, Song, R. , Boehm, S.M., Mengel, M., von Wasielewski, R.,Lindschau, C., Kirsch, T., de Groot, K., Laudeley, R., Niemczyk, E., Gueler,G., Menne, J., Haller, H., & Fliser, D. Circulation in press

First name:Ferdinand Hermann

Last name:Bahlmann


Country:Germany


Supervisor:Prof. HallerNephrology

EducationCollege/University:1995-98 Bhavans‘ Vivekananda College,

Secunderabad, India; B.Sc. (Genetics,Botany, Chemistry),

1998-2000 Sri Ramachandra Medical College andResearch Institute, Chennai, India;M.Sc.(HumanGenetics)

Highest degree:M.Sc.

Major Subjects:Human Genetics

Projects/Research:-Molecular genetics of Retinoblastoma-Secondary alterations in Mantle cell lymphomas

Scholarships:Scholarship from the „ Gesellschaft der Freunde der MHH“

Scientific Interests and Goals:I am interested in the analysis of a commonly deleted chromosomal region(1p22), in Mantle cell lymphomas and the search for tumor suppressor genes in this region.

Hobbies and other interests:Photography,Travelling, Music, Reading, Poetry

First name:Asha

Last name:Balakrishnan


Country:India


Supervisor:Prof. SchlegelbergerCell and Molecular Pathology

EducationCollege/University:1994-1996 University of Hamburg, Physics1995-2001 University of Hamburg,Medicine

Highest degree: MD (Dr. med.)

Major Subjects:Molecular Biology, Neurobiology

Projects/Research:Influence of CAMs (L1, CHL1) on Differentiation/Regeneration in the Central Nervous System

Scholarships:Grant from TWS, Graduiertenkolleg

Hobbies and other interests:History, Geography, Sports, Close-Up-Magic

First name:Christian

Last name:Bernreuther


Country:Sweden


Supervisor:Prof. C. GrotheNeuroanatomy

EducationCollege/University:1991-1999 Hannover Medical School


Major Subjects:Molecular biology, inflammation

Projects/Research:Regulation of gene expression ininflammation

Scientific Interests and Goals:See projects/research above

Hobbies and other interests:Soccer, tennis, biking

Publications:Kafert S, Winzen R, Loos A, Bollig F, Resch K, Holtmann H. FEBS Lett. 1998; 421(1):2-6.Bollig F, Winzen R, Kracht M, Ghebremedhin B, Ritter B, Wilhelm A, Resch K, Holtmann H. Eur. J. Biochem. 2002; 269(23):5830-9.Bollig F, Winzen R, Gaestel M, Kostka S, Resch K, Holtmann H.Biochem Biophys Res Commun. 2003; 301(3):665-70

First name:Frank

Last name:Bollig


Country:Germany


Supervisor:Prof. HoltmannPharmacology

EducationCollege/University:1995-2000 Hannover Medical School2001/2002 Surgical Resident, MHH2003/2004 Research Fellow, Centenary Institute

University of Sydney


Major Subjects:Hepatic Stem CellsMesenchymal Stem CellsImmunosuppression by antibodiesCD45

Projects/Research:• Bone marrow to hepatocyte plasticity models• Experimental immunosuppression by anti-CD45 mAbs• Liver regeneration by mesenchymal stem cells• Socio-demographic studies in living donation• Models for technical surgical questions

Scholarships:Educational Grant by the DFGInternal Grant by the MHH (HiLF)

Scientific Interests and Goals:Making stem cell therapy feasible

Latest Publications:Ko S, Dahlke MH, Lauth O, Jager MD, Deiwick A, et al. Exp Hematol. 2001; 29(3):339-44.Dahlke MH, Lauth OS, Jager MD, Roeseler T, Timrott K, et al. Blood. 2002;99(10):3566-72.Ko S, Jaeger MD, Dahlke MH, Nakajima Y, Schlitt HJ. Curr Mol Med. 2002; 2(3):249-55.Dahlke MH, Popp FC, Bahlmann FH, Aselmann H, Jaeger MD, Neipp M, Piso P Klempnauer J, Schlitt HJ. J Hepatol 2003; 39(3):365-73.Dahlke MH, Schlitt HJ. Liver Trans, 2003; 9(10):1100-1.Dahlke MH, Larsen S, Rasko JE, Schlitt HJ. Leuk Lymph 2004,45(2):229-36Dahlke MH, Larsen S, Popp FC, Schlitt HJ, Rasko JE. Liver Trans, 2004, in press

First name:Marc H.

Last name:Dahlke


Country:Germany


Supervisor:Prof. SchlittDepartment for Surgery,University of Regensburg

EducationCollege/University: University of Indonesia; Jakarta, Indonesia

Highest degree: B.Sc. in Biology (with Honours)

Major Subjects:Human Biology (Genetics)

Projects/Research:The impact of telomere shortening, senescence signalling and telomerase on regeneration and cancer.

Scientific Interests and Goals:Telomere biology and cancer.To learn more about the role of telomerase and telomere in cancer initiation and progress.

Hobbies and other interests:Reading, watching movies and other live performances (music, operas, theater, dance).

Publications:Djojosubroto MW, Choi YS, Lee HW, Rudolph KL Telomeres and telomerase in aging, regeneration and cancer. Mol. Cells. 2003; 15: 164-175.

Yusuf I, Djojosubroto MW, Ikawati R, Lum K, Kaneko A, Marzuki S. AdvExp Med Biol. 2003; 531: 37-46.

Keenihan SH, Gramzinksi R, Ratiwayanto S, Hadiputranto H, Riberu W, Soebianto S, Rusjdy F, Syafruddin D, Kartikasari A, Djojosubroto M, et al.Adv Exp Med Biol. 2003; 531: 83-102.

First name:Meta

Last name:Djojosubroto


Country:Indonesia


Supervisor:PD Dr. med. KL RudolphDept. Gastroenterology, Hepatology, and Endocrinology

EducationCollege/University:1987- 1994 Gymnasium Langenhagen 1999-2001 Wayne State University School of Medicine,

Detroit, MI, USA1994- 2001 Hannover Medical School


Major Subjects:Microbiology, Molecular Biology

Projects/Research:Pathogen-host interaction of Chlamydia trachomatis

Scholarships:DAAD

Scientific Interests and Goals:PhD-Degree, Investigation of the pathogen-host interactions in Chlamydia trachomatis induced arthritis on a molecular and product level.

Publications:Freise J, Gérard HC, Bunke T, Whittum-Hudson JA, Zeidler H, et al. Ann Rheum Dis. 2001; 60(2):140-5.Gérard HC, Freise J, Wang Z, Roberts G, Rudy D, et al. Microbes Infect. 2002; 4(1):13-22

First name:Julia

Last name:Freise


Country:Germany


Supervisor:Prof. Dr. H. ZeidlerRheumatology

EducationCollege/University:University of Frankfurt/Main, Germany


Major Subjects:Medicine, Cell Biology

Projects/Research:Induction of homologous recombination by site-specific meganucleases

Scholarships:Studienstifung des Deutschen Volkes (1993-2000)

Scientific Interests and Goals:Gene therapy, bone marrow failure syndroms

Hobbies and other interests:carpe diem

Publications:Kirin SI, Happel CM, Hrubanova S, Weyhermüller T, Klein C, Metzler-Nolte N; Dalton Transactions 2004; in pressHobmayer B, Snyder P, Alt D, Happel CM, Holstein TW. Cell Tissue Res2001; 304: 147-157Hobmayer B, Rentzsch F, Kuhn K, Happel CM, Cramer v Laue C, Snyder P,Rothbächer U, Holstein TW. Nature 2000; 407: 186-189

First name:Christoph M.

Last name:Happel


Country:Germany


Supervisor:Prof. C. KleinPediatrical Hematologyand Oncology

EducationCollege/University:Faculty of Nature SciencesUniversity of P.J SafarikDepartment of Molecular Biology; Kosice, Slovakia

Highest degree:Dr. rer. nat. (RNDr.)

Major Subjects:Molecular biology, neurobiology, chronobiology

Projects/Research:Circadian RhythmsThe Role of PKCα in Circadian Rhythms

Scientific Interests and Goals:My aim is to improve myself in research, to be good scientist...

Hobbies and other interests:life, nature, travelling, music, ...

First name:Vladimira

Last name:Jakubcakova


Country:Slovakia


Supervisor:Prof.EicheleMax-Planck-Institute of Experimental Endocrinology

EducationCollege/University:1994-1999 Bachelor of Medicine Univ. in Xi‘An1999-2001 Master of Medicine Univ. in Xi‘An

Higest degreeM.B., M.Sc. in Medicine

Major subjectPulmonary Transplantation Immunology

Project /Research2003 - Suppression of MHC-Class II molecule up regulation by HMG-CoA reductase inhibitors in an allogeneic model of rat lung transplantation2002 - Tissue engineered carotids: immunological,histological and molecular characteristics

Scientific Interests and GoalsEvery aspect concerning the lungLung Transplantation & Transplant ImmunologyLung Preservation & Ischemia reperfusion injuryPulmonary Stem cell & Tissue EngineeringThoracic & Experiment Surgery

Hobbies and other interestsI have many hobbies, please visit my personal website, or leave message on my BBS.

First Name:Yijiang

Last name:Li


Country:China

E-mail:[email protected]:www.ki.mycm.net

Supervisor:Prof. Axel Haverich

EducationCollege/University:1991-1996 Peking University Medicine

Highest degree:MD

Major Subjects:Immunology, molecular biology

Projects/Research:Transplantation tolerance induction

Scientific Interests and Goals:Pursuing a position as a research scientist, specifically in the area of transplantation tolerance induction.

Hobbies and other interests:Travel,running, music, chess

First name:Jian-Yun

Last name:Liu


Country:China


Supervisor:Prof. SchlittVisceral and Trans-plantation Surgery

EducationCollege/University:Hannover Medical School

Highest degree:MD (Dr.med.)

Major Subjects:Internal Medicine/Hepatology

Projects/Research:Cell cycle regulation in the liver, antiapoptotic pathways in liver injury

Scholarships:Award from „Studienstiftung des Deutschen Volkes“

Scientific Interests and Goals:Cell cycle regulation in the liver, antiapoptotic pathways in liverinjury

Hobbies and other interests:piano, soccer, travelling, meeting with friends, reading

Publications:Lüdde T, Kubicka S, Plumpe J, Liedtke C, Manns MP, Trautwein C. Oncogene 2001; 20(38):5264-78.Luedde T, Wuestefeld T, Trautwein C. Hepatology 2001; 34(6):1254-6.Luedde T, Liedtke C, Manns MP, Trautwein C. Eur Cytokine Netw. 2002; 13(4):377-83.Luedde T, Rodriguez M, Tacke F, Xiong Y, Brenner D, Trautwein C. Hepatology. 2003; 37(4):833-41

First name:Tom

Last name: Lüdde


Country:Germany


Supervisor:Prof. TrautweinGastroenterologyand Hepatology

EducationCollege/University:Ankara University Medical Faculty

Highest degree:MD, Associate Prof. in Pathology

Major Subjects:Pathology, Molecular Pathology

Projects/Research:Quantitative expression of gene expression in differentmechanisms of early allograft damage after renaltransplantation

Scientific Interests and Goals:To have an insight to molecular pathology and combine thisknowledge for my future pathology practice focusing on hematological malignancies

Hobbies and other interests:Drawing, music, reading, travelling, volleyball

Publications:Serinsöz E, Ensari A. Turkish Journal of Gastroenterology 2000; 4(3): 267-274.Unal AE, Bayar S, Serinsoz E, Kocaoglu H. Hepatogastroenterology 2002; 49(44):556-7.Yorganci A, Serinsoz E, Ensari A, Sertcelik A, Ortac F.Gynecol Oncol. 2003 Aug;90(2):478-81.Serinoz E, Varli M, Erden E, Cinar K, Kansu A, Uzunalimoglu O, Yurdaydin C, Bozkaya H. J Clin Gastroenterol. 2003 Mar;36(3):269-72.Bock O, Serinsoz E, Neusch M, Schlue J, Kreipe H. Br J Haematol. 2003 Nov;123(3):472-4.Li Z, Schwieger M, Lange C, Kraunus J, Sun H, van den Akker E, Modlich U, Serinsoz E, Will E, von Laer D, Stocking C, Fehse B, Schiedlmeier B, Baum C. Exp Hematol. 2003 Dec;31(12):1206-14.Bock O, Serinsoz E, Schlue J, Kreipe H.Leuk Res. 2004 May;28(5):457-60.Bock O, Schlue J, Mengel M, Busche G, Serinsoz E, Kreipe H.J Pathol. 2004 May;203(1):609-15

First name:Ebru

Last name:Serinsöz


Country:Turkey


Supervisor:Prof. KreipePathology

EducationCollege/University:1994-2001 Hannover Medical School1998-1999 University of Texas MD Anderson Cancer Center2000 Baylor College of Medicine, Houston, TX

Highest degree:Dr. med.

Major Subjects:Internal Medicine, Immunology, Hepatology, Virology

Projects/Research:Influence of mutations in the Hepatitis B Virus genome on virus replication and drug resistance (PhD thesis)Humoral regulation of thrombopoiesis and its clinical impact in patients with chronic liver diseases and in healthy volunteers (MD thesis)Gene transfer of inducible Bcl-Xs in myeloid leukemia (research scholarship at MD Anderson Cancer Center, Houston, TX, USA, 1998-1999)

Scholarships:1998-1999 DAAD-Funding

Scientific Interests and Goals:Molecular understanding of the basic virology of hepatitis B virus replication and of clinical problems such as drug resistance or fulminant hepatitisDefining the impact of cytokine dysregulation for the clinical course and complications in patients with chronic liver disease

Hobbies and other interests:Music, travel, art, literature, sports, party!

Publications:Tacke F, et al. Br J Haematol 1999; 105(2):511-513Tacke F, et al. Blood Coagul Fibrinolysis 2001; 12(7):539-545Schöffski P, Tacke F, et al. Liver 2002; 22:114-120Tacke F, et al. Liver 2002; 22:205-212 Tacke F, et al. J Hepatol 2003, 38(4):447-454Luedde T, Rodriguez M, Tacke F, et al. Hepatology 2003, 37(4):833-841Tacke F, et al. Blood Coagul Fibrinolysis 2003, 14(4):319-325Streetz KL, Tacke F, et al. Hepatology 2003, 38(1):218-229Tacke F, et al. Cancer Biol Ther 2004, 3(3)Tacke F, et al. Scand J Gastroenterol 2004 (in press)Tacke F, et al. Current Medicinal Chemistry 2004 (in press)

First name:Frank

Last name:Tacke


Country:Germany


Supervisors:Prof. Dr. C. TrautweinGastroenterology,Hepatology & Endocrinology

EducationCollege/University:1992 – 1998 DVM, Veterinary Medicine Addis Ababa

University1999 – 2001 MSc., Animal Pathology, Utrecht University

Highest degree:DVM, MSc.

Major Subjects:Cancer genetics, Host-pathogen interaction

Projects/Research:DNA methylation patterns in Myelodysplastic syndromes (MDS)

Scholarships:Nuffic: Netherlands University Fellowships Programme

Scientific Interests and Goals:My area of interest is cancer genetics and I am particularly interested in finding molecular targets for diagnosis and therapy of cancer.

Hobbies and other interests:Music, literature, movies and football

Publications:Mathewos Z, Getachew A, Yilma J. Revue. Méd. Vét. 2001, 152, 851-858.Tessema MZ, van Tongeren SE, Doresstein GM. Eur. J. Vet. Pathol. 2000, 6, 121-124.Tessema MZ, Koets AP, Rutten VPMJ, Gruys E. Vet. Quart. 2001, 23, 153-162.Tessema M, Länger F, Dingemann J, Ganser A, Kreipe H, Lehmann U. Leukemia 2003; 17(5):910-8Tessema M, Lehmann U, Kreipe H. Virchows Arch. 2004; 444(4):313-23.

First name:Mathewos

Last name:Tessema


Country:Ethiopia


Supervisors:Prof. KreipeDr. LehmannPathology

EducationCollege/University:1994-2001 Studies of Medicine; Hannover Medical School1997-2001 MD thesis (Basic immunology)


Major Subjects:Immunology, Rheumatology, Molecular Biology

Projects/Research:- New therapeutic approaches and

pathogenesis of autoimmune diseases- Interaction of immune complexes with Fc receptors- Differentiation and functional characterization of CD8β+ T cells

Scholarships:Grant from Hannover Medical School (HiLF programe)

Hobbies and other interests:Sports and photography

Publications:Werwitzke S, Drescher B, Schmidt RE, Witte T. Immunobiology 2000, 202:168-171Witte T, Werwitzke S, Schmidt RE. Immunobiology 2000, 202:194-198Werwitzke S, Tiede A, Drescher BE, Schmidt RE, Witte, T. Clinical andExperimental Immunology 2003, 133:334-43Werwitzke S, Tiede A, Stoll M, von Depka M. Journal of Thrombosis and Haemostasis 2004, 2:193-4

First name:Sonja

Last name:Werwitzke


Country:Germany


Supervisor:Prof. R.E. SchmidtClinical Immunology

Year 2002

Diya Abraham

Syed Raza Ali

Johannes Beckermann

Georg Bohn

Thomas Gebhardt

Shashi Kant

Claudia Karacsonyi

Axel Karow

Varsha Kumar

Gesa Meyer

Anika Meyerholz

Christina Nassenstein

Axel Schambach

Aravind Sekhar

Amar Deep Sharma

Srinivas Annavarapu Rao

Krishna Kumar Singh

Manvendra Singh

Frank Traub

Linding Wang

EducationCollege/University:1999 B.Sc.-University of Mysore, India2001 M.Sc.-University of Mysore, India

Highest degree:M.Sc. in Biochemistry

Major Subjects:Microbiology, Zoology, Botany

Projects/Research:Analyzing the in vivo function of protein kinase C byusing mutant mice (knock outs).

Scholarships:1. Gold medallist in Master of Science2. Venkataraman Aarthie award

Scientific Interests and Goals:My main field of interest is Genetics and Molecular Biology.With the expertise I gain from these fields I would like tocontribute to the upliftement of mankind and society and alsounderstand to certain extent the great complexity of life.

Hobbies and other interests:Singing, Dancing, Cooking, Interior decoration, Reading,Flower arrangement

First name:Diya

Last name:Abraham


Country:India


Supervisor:Dr. M. LeitgesMax-Planck-Institutefor ExperimentalEndocrinology

EducationCollege/University:1999-2001 University of Pondicherry, India


Major Subjects:Biotechnology

Projects/Research:Molecular characterization of complement-mediated FcγR gene regulation as an amplification loop of the innate immune response to immune complexes.

Scholarships:1. Awarded By DBT, India for selecton in All India Combined M.Sc. Biotechnology Program (1999-2001).2. Junior Research Fellowship awarded by Council for Scientific and Industrial Research, India (July, 2001).3. Grant from the „Gesellschaft der Freunde der MHH“ for my doctorate study.

Scientific Interests and Goals:To study the regulatory aspects of transcription at the level of protein-DNA interaction.

Hobbies and other interests:Music, travel and cricket

First name:Syed

Last name:Raza Ali


Country:India


Supervisor:Prof. GessnerClinical Immunology

EducationCollege/University:1996-2002 in Marburg, London, Hannover


Major Subjects:Nephrology

Projects/Research:UPA/UPAR in endothelial progenitor cells

Scholarships:DAAD

Scientific Interests and Goals:Signal transduction, endothelial progenitor cells, internalmedicine, clinical nephrology

First name:Johannes

Last name:Beckermann

Country:Germany


Supervisor:Prof. DumlerNephrology

EducationCollege/University:1994-1997 Albert Ludwigs Universität Freiburg1997-1998 Universidad de Salamanca, Spain1998-2002 Technische Universität München



Projects/Research:Identification and characterization of three novel auxiliary γsubunits of voltage gated calcium channelsGeneration and characterization of hematopoietic stem cell lines as novel tools to investigate genetic and developmental aspects of congenital bone marrow failure syndromes

Scientific Interests and Goals:Identification and characterization of yet undefined congenital bone marrow failure syndromes and the genuine role of hematopoietic stem cells in the development and differentiation of the hematopoietic system

Hobbies and other interests:Music, opera and exhibitions, cooking

Publications:Klugbauer N, Dai S, Specht V, Lacinova L, Marais E, Bohn G, Hofmann F. FEBS Lett 2000; 470: 189-197Bohn G, Moosmang S, Conrad H, Stieber J, Ludwig A, Biel M, Klugbauer N, Hofmann F. JPN J Electrcardiol 2000; 20: 76-78Bohn G, Moosmang S, Conrad H, Ludwig A, Hofmann F, Klugbauer N. FEBSLett 2000; 481: 73-76Moosmang S, Bohn G, Conrad H, Ludwig A, Biel M, Klugbauer N, Hofmann F (2001) “Molecules contributing to cardiac pacemaker current” in Morad M, Kostyuk P Calcium Signaling (IOS Press): 262-264

First name:Georg

Last name:Bohn


Country:Germany


Supervisor:Prof. KleinPediatrical Hematologyand Oncology

EducationCollege/University:Hannover Medical School


Projects/Research:Regulation of mast cells by cytokinesMast cell-nerve interactions

Hobbies and other interests:Jogging, Collecting records, Travelling

Publications:Zender L, Kock R, Eckhard M, Frericks B, Gosling T, Gebhardt T, DrobekS, Galanski M, Kuhnel F, Manns M, Kubicka S. Gastroenterology. 2002; 123:608.Gebhardt T, Sellge G, Lorentz A, Raab R, Manns MP, Bischoff SC. Eur J Immunol. 2002; 32:2308Bedoui S, Lechner S, Gebhardt T, Nave H, Beck-Sickinger AG, Straub RH, Pabst R, von Horsten S. J Neuroimmunol. 2002; 132:25.Lorentz A, Klopp I, Gebhardt T, Manns MP, Bischoff SC. J Allergy Clin Immunol. 2003; 111:1062.Sellge G, Lorentz A, Gebhardt T, Levi-Schaffer F, Bektas H, Manns MP, Schuppan D, Bischoff SC. J Immunol. 2004; 172:260.

First name:Thomas

Last name:Gebhardt


Country:Germany


Supervisor:Prof. S.C. BischoffGastroenterology,Hepatology, and Endocrinology

EducationCollege/University:2000-2002 School of Biotechnology, Madurai Kamarej University, Madurai, India



Projects/Research:Mechanisms of activation and substrate targeting in the MAP kinase cascadesCotransformation of multiple T-DNAs: Segregation analysis in the T1generationHydrophobic conserved residues of homeodomains

Scholarships:Have received DBT (Department of Biotechnology) studentship for 2years during my M.Sc.Have received educational stipend during my B.Sc. under rural experience program.

Scientific Interests and Goals:I am interested in the study of molecular mechanisms of activation of MAP kinase cascade and it´s target proteins.

Publications:Kant S, Bagaria A, Ramakumar S.Biochem Biophys Res Commun. 2002; 299(2):229-32.

First name:Shashi

Last name:Kant


Country:India

E-mail:[email protected]@mh-hannover.de

Supervisor:Prof. Dr. M. GaestelPhysiological Biochemistry

EducationCollege/University:University of Buenos Aires

Highest degree:M.Sc. in Biochemistry

Major Subjects:Biochemistry / Biotechnology

Projects/Research:•The role of lipid rafts in the antigen presentation pathway. Hannover Medical School, Germany.•Design of a transfer vector for the production of recombinant AgMNPV. IBBM, U of La Plata, Argentina.(2002)•Design of an Enzyme immune assay for the detection of GADA. Department of Immunology, U of Buenos Aires, Argentina.(2001-2002)•Study of different mutations in the ccr5 gen and their relationship with HIV-1. Department of Genetics, U of Buenos Aires, Argentina.(1999)

Scholarships:CADIE studentship for an interchange course at the University of Massachusetts, Amherst.

Scientific Interests and Goals:To become a doctor and continue my education in the researchfield.

Hobbies and other interests:Travel, sports, cinema

First name:Claudia Victoria

Last name:Karacsonyi


Country:Argentina


Supervisor:Dr. LindnerCell Biology

EducationCollege/University:1995-2002 Hannover Medical School

Highest degree:MD (Dr.med.)

Major Subjects:Microbiology, Pediatrics

Projects/Research:Enterohemorrhagic Escherichia coliAcute lymphoblastic leukemia

Scientific Interests and Goals:My main interest is to contribute to further insight into antileukemic immunity

Hobbies and other interests:Running, travel, soccer, literature

First name:Axel

Last name:Karow


Country:Germany


Supervisor:Prof. KleinPediatrical Hematology And Oncology

EducationCollege/University: 2000-2002 Madurai Kamaraj University

Highest degree:M.Sc. in Biochemical Technology

Major Subjects:Immunology

Projects/Research:Analysis of the coupling mechanism between C5a anaphylatoxinand FcγRs in Ab-dependent models of nephritis and autoimmune hemolytic anemia

Scholarships:Graduiertenkolleg (GK 705)

Scientific Interests and Goals:Unravelling the molecular aspects of diseases, thus contributingtowards research in medicine.

Hobbies and other interests:painting, travelling, reading books and an avid animal lover

First name:Varsha

Last name:Kumar


Country:India


Supervisor:Prof. Gessner JEClinical Immunology

EducationCollege/University:1995-2003 School of Veterinary Medicine Hannover, Germany

Highest degree:MD

Major Subjects:Toxicology, Cell Biology

Projects/Research:Molecular mechanisms of the inflammatory response of mast cells and colonocytes induced by Clostridium difficile toxins A and B: analysis of toxin-induced pro-inflammatory signal cascades.

Scientific Interests and Goals:To get further insights into the pathogenesis of intestinal inflammation induced by bacterial toxins using molecular and immunological techniques

Hobbies and other interests:Everything related to music: playing the violin, dancing…

First name:Gesa

Last name:Meyer


Country:Germany


Supervisor:Prof. Dr. JustInstitute of ToxicologyHannover Medical School

EducationCollege/University:1995-2002: Hannover Medical School, Human medicine


Major SubjectsInternal medicine, cell biology

Projects/Research:Role of CALM in clathrin dependent transport mechanisms

Scientific Interests and Goals:My main interest is the influences of transport processes during the developm4ent of haematological malignancies

Publications:Umeda A, Meyerholz A, Ungewickell E. Eur J Cell Biol. 2000; 79(5): 336-42.

First name:Anika

Last name:Meyerholz


Country:Germany


Supervisor:Prof. Dr. UngewickellCell biology

EducationCollege/University:1995-2002 Albert-Ludwigs-University Freiburg, Germany

Highest degree:MD

Major Subjects:(Neuro-) Immunology, Allergology, Pneumology

Projects/Research:Mechanisms of Neurogenic Inflammation in Allergic Asthma: TheRole of the Neurotrophin Receptors TrkA, TrkB, TrkC und p75NTR

Scientific Interests and Goals:To get further insights to the pathogenesis of allergic asthma as well as neuro-immune interaction using physiological, immunological and molecular techniques in diverse in-vitro and in-vivo test-systems.

Hobbies and other interests:My big fat horse “Fly“; Literature

Publications:Virchow JC Jr, Faehndrich S, Nassenstein C, Bock S, Matthys H, Luttmann W.Clin Exp Allergy. 2001 Jun;31(6):836-44Nassenstein C, Braun A, Erpenbeck VJ, Lommatzsch M, Schmidt S, Krug N, Luttmann W, Renz H, Virchow JC jr. J Exp Med. 2003 Aug 4;198(3):455-67Nassenstein C, Kerzel S, Braun A. Prog Brain Res. 2004;146:347-67

First name:Christina

Last name:Nassenstein


Country:Germany


Supervisor:Dr. BraunFraunhofer-Institute ofToxicology and Experi-mental Medicine

EducationCollege/University:1995-2001 University of Hamburg, Medicine2001 Scripps Research Institute (USA), UCSF (USA)

University of Zürich (Switzerland)


Major Subjects:Hematology, Virology, Molecular Biology

Projects/Research:Regulation of Gene Expression in Retroviral VectorsGenetics of Lipid Metabolism

Scholarships:1996-2001 Scholarship „Studienstiftung des Deutschen

Volkes“

Scientific Interests and Goals:Molecular origin of diseases. Connection of basic scienceapproaches with clinical applications. Gene therapy,transplantation.

Hobbies and other interests:Beach Volleyball, Soccer, Travel

Publications:Ries S, Buchler C, Schindler G, Aslanidis C, Ameis D, et al. Hum Mutat.1998; 12 (1): 44-51.Wodrich H, Schambach A, Krausslich HG. Nucleic Acids Res. 2000,284(4): 901-10Schambach A, Wodrich H, Hildinger M, Bohne J, Krausslich HG, BaumC. Mol Ther. 2000, 2(5): 435-45.

First name:Axel

Last name:Schambach


Country:Germany


Supervisor:Prof. BaumHematology

EducationCollege/University:1996-2002 Bangalore Medical College, Bangalore

Highest degree:M.B.B.S.(Bachelor of Medicine & Surgery)

Major Subjects:Medicine, Surgery, Obstetrics & Gynaecology

Projects/Research:Genes specifically expressed in intestine epithelium

Scholarships:JNCASR Summer Research Fellowship `98

Scientific Interests and Goals:Developmental biology

Hobbies and other interests:Travel, Reading, Rock Music, Calligraphy

First name:Aravind

Last name:

Sekhar


Country:India


Supervisor:Prof. GosslerMolecular Biology

EducationCollege/University:J.N.U. New Delhi, India

Highest degree:M.Sc. in Bioechnology

Major Subjects:Cell Biology, Immunology and Molecular Biology

Projects/Research:Differentiation of adult as well as embryonic stem cells into hepatocytes.

ScholarshipsDepartment of Biotechnology in India

Scientific Interests and Goals:I am interested in stem cell biology and want to exploretheir potential for therapeutic purposes.

Hobbies and other interests:Watching cricket matches

First name:Amar Deep

Last name:Sharma


Country:India


Supervisor:Prof. OttGastroenterology, Hepatology andEndocrinology

EducationCollege/University:1992-1997 M.B.B.S; Dr S.N Medical College, Jodhpur, India1998-2001 MD Pathology; AFMC, Pune, India2001 Diplomate National Board (DNB) Pathology

Highest degree:MD Pathology ; DNB Pathology

Major Subjects:Pathology, Hematology and Oncology

Projects/Research:Gastrointestinal stromal tumours: A Light microscopic, Ultrastructuaral & Immunohistochemical Correlation of 30 cases.Redifferentiation stratergies for thyroid cancer

Scientific Interests and Goals:To translate molecular research into clinical diagnostics and therapeutics

Hobbies and other interests:Guitar, Cars, Travel and Cricket

Publications:Mishra DK, Rai R, Rao AS. Indian J. Hematol.& Blood Transf. 1999; 17: 20 Rao A, Mishra DK, Subramanya H. Indian J. Hematol.& Blood Transf. 2000; 18: 90-94.

First name:Srinivas

Last name:Annavarapu Rao


Country:India


Supervisor:Prof. BrabantEndocrinology

EducationCollege/University:1995-98 Udai Pratap College/ Purvanchal University1998-1999 Benaras Hindu University 1999-2001 Goa University


Major Subjects:Cell and Molecular Biology, Biochemistry, Biophysics, Immunology, Microbiology and Genetic Engineering

Projects/Research:Genetics of retinal drusen formation in Rhesus Macaques.

Scholarships:Grant from the Pro Retina.

Scientific Interests and Goals:I want to pursue my research in the field which has somedirect effect in medical sciences.

Hobbies and other interests:Music, Novels, Cricket and Chess

First name:Krishna Kumar

Last name:Singh


Country:India


Supervisor:Prof. SchmidtkeHuman Genetics

EducationCollege/University:2000-2002 Madurai kamaraj University M.Sc in Biotechnology.



Projects/Research:1. Construction of antisense vector to studythe process of Melaninbiosynthesis and UV induced inflammation.2. Production, purification, characterization and comparative study of a protease from a thermophilic fungi Thermomycese lanuginosus.

Scholarships:1. Awarded by DBT,india for selection in All india combined M.Sc. biotechnology programe (2000-2002).2. Junior Research Fellowship (JRF) awarded by Council for Scientific and Industrial Research (CSIR), India.3. R&D Assistantship from JNCASR, Bangalore, India.

Scientific Interests and Goals:My main field of interest is Developmental Biology, I want tostudy the biology of Somite and Limb Patterning. I would consider myself to be successful in my ambition if I am in any way able to add to the knowledge that will ultimately help us tounderstand this fascinating area of biology better.

Hobbies and other interests:Music, Cricket, Movies, literature, etc.

First name:Manvendra

Last name:Singh


Country:India


Supervisor:Prof. KispertMolecular Biology

EducationCollege/University:1995-2001 Philipps University Marburg (Germany)2001-2002 University of Pretoria (South Africa) 2002 Pritzker School of Medicine Chicago (USA)

Highest degree:MD

Major Subjects:Microbiology, Cell Biology, Proteomics

Projects/Research:Influence of BMP-2 on human bone marrow cellsProteinprofile of human breast cancer

Scholarships:Forschungspool der Universität Marburg (2000)

Scientific Interests and Goals:Tumor growth and development

Hobbies and other interests:swimming, handball, economics, travelling

Publications:Wilke A., Traub F., Kienapfel H., Griss P. Biochem Biophys Res Commun. 2001; 284:1093-7.

First name:Frank

Last name:Traub


Country:Germany


Supervisor:Prof. KreipePathologie

EducationCollege/University:Anhui UniversityShanghai Institute of Biological Products

Highest degree:M.Sc. in Pathogenic Microbiology & Molecular Biology

Major Subjects:Cloning and expression of HIV-1 gag p24, env gp41 recombinantantigens and p24-gp41 fusion recombinant antigen in Escherichiacoli

Projects/Research:FunctiofFunctional characterization of M-type K15 of Kapos’s Sarcoma-Associated herpesvirus

Scholarships:DAAD

Scientific Interests and Goals:Molecular biology and virology;grasp the highest standardtechniques and serve the people

First name:Linding

Last name:Wang


Country:China


Supervisor:Prof. SchulzVirology

Year 2003

Khaled Alkasah

Tammy Chang

Anuhar Chaturvedi

Dorothea Dijkstra

Dorothea Gadzicki

Jaba Gamrekelashvili

Arnab Ghosh

Shipra Gupta

Eric Hesse

Kumaravelu Jagavelu

Gustavo Salguero Lopez

Harini Nivarthi

Andri Pramono

Rahul Purwar

Bishnudeo Roy

Tibor Veres

Anastassiia Vertii

Ajit K. Yadav

EducationCollege/University:1992-1996 BSc in Medical Laboratories, Sana´a University, Yemen.

Highest degree:MSc in Medical Microbiology, Sana´a University, Yemen.

Major Subjects:Microbiology, Haematology and Biochemstry.

Projects/Research:Viral and Genetic Detreminants of KSHV/HHV-8 Transmission from Mother to Child.

Scholarships:DAAD

Hobbies and other interests:Swimming and other sports

First name:Khaled

Last name:Alkharsah


Country:Syria


Supervisor:Prof. Dr. T. F. Schulz Virology

First name:Tammy

Last name:Chang


Country:Taiwan (R.O.C.)

E-mail:Tammy_CYS@ web.de

Supervisor:Prof. TümmlerKlinische Forschergruppe“Molecular Pathology of Cystic Fibrosis”

Education

College / University:

1995-1997 Phillipps University Marburg, Germany

1997-2003 Justus-Liebig University Gießen, Germany

Highest degree:

Dipl. oec. troph.

Major Subjects:Biochemistry of Nutrition, Nutrition in developing countries

Project / Research:

Pseudomonas aeruginosa – mammalian host cell interaction: Phagocyte-sensitizing genes of P. aeruginosa

Scientific Interests and Goal:Genotypic and phenotypic characterization of baterial fitnessand virulence factors in Pseudomonas using biochemical, biological and/or biophysical assays

Hobbies and other interests:There are a lot of other things outside the lab which are also to be discovered. But above all, the one who created all things on earth, is of most interest.

Publications:Iozef R, Rahlfs S, Chang T, Schirmer H, Becker K. FEBS Letters 2003 Oct;554:284-288

EducationCollege/University:B. Pharm - June 1997 to July2001 Department of Pharmaceutical

Sciences and Drug Research, Punjabi University Patiala, Punjab India.

MS (Pharm) Biotechnology - July 2001 to Dec 2002National Institute of Pharmaceutical Education and Research ,

Mohali, Punjab. India

Highest degree:MS(Pharm)

Major Subjects:Pharmacology, Pharmaceutics, Biotechnology

Projects/Research:Functional genomics using RNA-interference in hematopoietic

cells

Scientific Interests and Goals:Functional analysis of individual signaling molecules by means

of RNAi in primary normal and malignant hematopoietic cells thus to find targets for therapeutic interventation.

Scholarships1. Awarded by National Institute of Pharmaceutical

Education and Research for MS(Pharm) in Biotechnology-July 2001 to Dec 2002

2. Junior Research Fellowship awarded by Council of Scientific and Industrial Research India (Dec, 2002 )

3. Grant from Deutsche Forschungsgemeinschaft for my doctorate study

Hobbies and other interests:Movies, Travelling and cooking

Publications:Review ArticleShruti Agarwal, Anuhar Chaturvedi, Nilanjan RoyPharmacogenomics –The concept behind Personalized Medicine.Current Research and Information in Pharmaceutical SciencesVol. 3 No. 3 July - September 2002

First name:Anuhar

Last name:Chaturvedi


Country:India


Supervisor:Prof. Matthias EderHematology and Oncology

First Name:Dorothea (Dorrit)

Last Name:Dijkstra

Date of Birth:28.10.1977

Country:The Netherlands


Supervisors:Prof. Dr. T. WerfelDr. R. GutzmerDermatology

Education College/University:1995-1999 Hogeschool IJsselland, Deventer, The

Netherlands1999-2001 Vrije Universiteit, Amsterdam, The

Netherlands

Highest degree:MSc (Drs.)

Major Subjects:Immunology, Dermatology, Pharmacology

Scientific Interests and Goals:To find out the role of anaphylatoxins C3a and C5a and their respective receptors in modulating the interaction between dendritic cells and T-lymphocytes in the skin. We will compare healthy subjects and patients with chronic inflammatory skin diseases as a model.

Hobbies and other interests:Parasitology (fascinating how they escape from host immune responses!), World Wildlife Foundation, Windsurfing, Skating, Friends, Drawing, Reading, Music, my parents dog Rocaille etc.

EducationCollege/University:1994-2001 Medizinische Hochschule Hannover, Germany

Highest degree:MD

Major Subjects:Genetics, Tumorigenesis

Projects/Research:Identification of secondary genetic changes in BRCA1/2-induced hereditary breast cancer development

Scientific Interests and Goals:To gain insight into fundamental molecular processes during breast cancer development, in particular of hereditary breast cancer, to improve the diagnostic procedures and adapt therapeutic strategies for a better prognostic outcome.

Hobbies and other interests:Literature, theatre, sports, drawing

Publications:D.Gadzicki, K.Müller-Vahl, M.Stuhrmann Molecular and Cellular Probes 1999; 13:321-323

D.Gadzicki, KR.Müller-Vahl, D.Heller, S.Ossegge, M.M.Nöthen, J.Hebebrand, M.Stuhrmann Am J Med Genet (published online 10 Feb 2004)

First name:Dorothea

Last name:Gadzicki


Country:Germany


Supervisor:Prof. Dr. med. Brigitte Schlegelberger,Cell and Molecular Pathology

EducationCollege/University:1996-2002 Tbilisi State Medical University, Tbilisi Georgia

Highest degree:MD

Major Subjects:Basic and tumor Immunology

Projects/Research:Influence of tumor cell death on tumor specific immune response

Scientific Interests and Goals:To clarify mechanisms of immune tolerance & activation in tumor immunity

Hobbies and other interests:Table tennis, football, neuroscience.

Publications:Nizharadze N, Gongadze M, Sanikidze T, Gamrekelashvili J, Sumbadze C, Kevlishvili O. Proc. Georgian Acad. Sci., Biol., Ser. A., 2002, 28: 573-576.

First name:Jaba

Last name:Gamrekelashvili


Country:Georgia


Supervisor:PD.Dr. T. GretenDepartment of Gastroenterology,Hepatology & Endocrinology

EducationCollege/University:1996-2001 Mysore Medical College, India

Highest degree:MBBS


Projects/Research:Mechanisms and modulation of anti-leukemia immunity

Scientific Interests and Goals:To obtain further insights into management of childhood leukemia

Hobbies and other interests:Exploring Indian wildlife; Anthropology and development oflanguages

First name:Arnab

Last name:Ghosh


Country:India


Supervisor:Prof. KleinPediatric Hematology and Oncology

EducationCollege/University:1998-2003: All India Institute of Medical Sciences (AIIMS), New Delhi, India

Highest degree:M.Biotech.

Major Subjects:Biotechnology, Molecular Biology, Immunology

Projects/Research:Generation and characterization of chemokine-derived peptides leading to the inactivation of chemokine receptors on

inflammatory cells

Scientific Interests and Goals:To know more about chemokines

Hobbies and other interests:Painting

First name:Shipra

Last name:Gupta


Country:India


Supervisor:Prof. Dr. J. ElsnerDermatology

EducationCollege/University:1996-2003 Hannover University Medical School, Germany

Harvard University Medical School, U.S.A.University of Birmingham, GBUniversity of Otago, New ZealandUniversity of Zurich, SwitzerlandUniversity of Cape Town, South Africa


Major Subjects:Cell Biology, Genetics, Tissue Engineering

Projects/Research:Gene- expression analysis of mesenchymal stem cells and theirmatrix- synthesis under functional aspects

Scientific Interests and Goals:Differentiation and characteristics of mesenchymal stem cells

Scholarship:Scholarship Foundation, Bayer Leverkusen AGDAADHannelore Munke Research Award

Hobbies and other interests:Sports (Jogging, Motorcycling, Swimming), Travelling, all my friends, Literature, good wine and food

Publications:Musholt PB, Hesse E, Musholt TJ, Petrich T, Pötter E, Oetting G, et al. ClinChem Lab Med 2001; 39:171.

Hesse E, Musholt PB, Petrich T, Pötter E, Lichtinghagen R, Musholt TJ, Knapp WH. Eur J Nucl Med Mol Imaging 2002; 29:183.

First name:Eric

Last name:Hesse


Country:Germany


Supervisor:Prof. M. v. GriensvenExperimentalTraumatology

EducationCollege/University:1997-1999 Bharathidasan University, Trichy, India

Highest degree:M.Sc.

Major Subjects:Microbiology

Projects/Research:Functional analysis of Tbx8 in muscle development.

Scientific Interests:To study the molecular aspeccts and signalling mechanisms of organ development.

Hobbies and other interests:Photography, Lepidoptery, Travelling

Publications:Kumaravelu J, Shanmugasundaram GK, Unwala H, Ramamoorthi N, Banerjea AC. Genes and Immunity 2001; 2, 404-407.

Ramamoorthi N, Kumaravelu J, Shanmugasundaram GK, Rani K, Banerjea AC. Genes and Immunity 2001; 2, 408-410.

First name:Kumaravelu

Last name:Jagavelu


Country:India


Supervisor:Prof.Dr KispertMolecular Biology

EducationCollege/University:1995-2001 Universidad Nacional de Colombia, Bogota Colombia

Highest degree:MD

Major Subjects:Cellular and molecular biology of cardiovascular diseases: Cellular and molecular mechanisms of angiogenesis.Role of progenitor cells in neovascularization

Projects/Research:Impact of biomechanical stretch in progenitor cell differentiation. Role of progenitor cells in Hypertension

Scientific Interests and Goals:My main goal is to apply the knowledge from research in molecular biology on the understanding of cardiovascular diseases. As a first approach I am working on in vitro and in vivomodels of vascular hypertension at a cellular and molecular level. It will open me new perspectives about potential applications of molecular technology and their impact on diagnostic and prevention strategies and more specific and effective treatments for these kind of diseases.

Hobbies and other interests:Take a walk by the mountains. Good music and literature.

First name:Gustavo

Last name:Salguero


Country:Colombia


Supervisor:PD. Bernhard SchiefferCardiology and Angiology

EducationB.Sc. Biochemistry, Daulat Ram College, Delhi Univrsity.M.Sc. Biotechnology, Madurai Kamaraj University

Highest degree:Master

Major Subjects:Biotechnology, Biochemistry

Projects/Research:Molecular analysis of transcription factors involved in dendritic cell developmernt

Hobbies and other interests:Reading, Indian classical dance.

First name:Harini

Last name:Nivarthi


Country:India


Supervisor:Prof. Dr. KleinPediatric Hematology and Oncology

EducationCollege/University:1999 B.Sc. University of Indonesia, Indonesia2003 M.Sc University of Indonesia, Indonesia

Highest degree:M.Sc. in Microbiology Medicine

Major Subjects:Cell Biology,Virology, Molecular Biology

Projects/Research:In vitro Hematopoietic Differentiation of Embryonic Stem Cells Using Gene Modified Vectors

Scientific Interests and Goals:My interest is unravelling the mechanism of hematopoiesis in embryonic stem cell and genetic control behind this

Hobbies and other interests:Playing Piano, travelling, watching movie

First name:Andri

Last name:Pramono


Country:Indonesia


Supervisor:Prof. Dr. K. WeltePediatrics

EducationCollege/University:Lucknow UniversityAll India Institute of Medical Sciences, New Delhi, India

Highest degree:M.Sc( Biochemistry)

Major Subjects:Biochemistry, Immunology

Projects/Research:T cell - keratinocyte interaction in chronic inflammatory skin

diseases

Scientific Interests and Goals:Doing good research in the field of Immunogy

Hobbies and other interests:Reading, Cricket

First name:Rahul

Last name:Purwar


Country:India


Supervisor:Prof.Dr. M. WittmannProf. Dr. T.WerfelDermatology

EducationCollege/University:2001-2003 School of Biotechnology, Madurai Kamaraj University, Madurai, India

Highest degree:MSc in Biotechnology


Projects/Research:Contribution of B1 cells to the gut associated humoral immunity.

Scholarships •Received DBT (Department of Biotechnology, India) studentship during my MSc.• Junior research fellowship (JRF) awarded by Counsil for Scientific and Industrial Research (CSIR), India

Scientific Interests and Goals:I Have a particular interest in understanding the complexity of the regulation of immune responses.

First name:Bishnudeo

Last name:Roy


Country:India


Supervisor:Dr. S. WeissMolecular ImmunologyGBF

EducationCollege/University:1996-2003 Semmelweis University Budapest, Hungary

Highest degree:MD

Major Subjects:Immunology, Neuroimmune Interactions, Respiratory Medicine

Projects/Research:Interaction between pulmonary dendritic cells and nerves during allergic airway inflammation

Scientific Interests and Goals:To reveal locations and mechanisms of cross-talk between the nervous and immune system and investigating the contribution of neuroimmune interactions to allergy

Hobbies and other interests:Music, literature, languages, hiking

Publications:Vannay A, Fekete A, Muller V, Strehlau J, Viklicky O, Veres T, Reusz G, Tulassay T, Szabo AJ. Kidney Blood Press Res. 2004

First name:Tibor

Last name:Veres

Date of birth:11. 06. 1978

Country:Hungary


Supervisor:Dr. BraunFraunhofer-Institute forToxicology and Experi-mental Medicine

EducationCollege/University:1993-1998 Kharkov State University -Kharkov, Ukraine2001-2003 Kadir Has University-Istanbul, Turkey

Highest degree:MSc

Major Subjects:Molecular Biology, Protein Interaction, Heat Shock Proteins

Projects/Research:Search for biological functions of Hsp25 phosphorylation

Scientific Interests and Goals:To understand the role of Hsp25 phosphorylation inthermoresistance and translational inhibition, particularly in Hsp25interaction with translation factors and Akt/PKB

Hobbies and other interests:Alpine skiing; Lab mice and Street cats

Publications:Memon A., Aktoprakligil D., Ozdemir A., Vertii A. Turk J. Bot 2001; 25:11-121

First name:Anastassiia

Last name:Vertii


Country:Ukraine


Supervisor:Prof. Dr. M. GaestelDr. A. KotlyarovPhysiological Chemistry

EducationCollege/University:2001-2003Jawaharlal Nehru University, New Delhi, India.

Highest degree:M.Sc in Biotechnology

Major Subjects:Molecular Biology

Projects/Research:Master Thesis; Stabilization of proteins by solvent engineering:Lysozyme as a modelCurrent Ph.D project: Characterization of biochemical pathways implicated in production of varieties of xylose containing glycans

Scholarships:Scholarship sponsored by DBT, India for Master education (2001-2003).Junior Research Fellowship (2003), awarded by ICMR, India.Presently, GK705 Fellowship for my Ph.D study.

Scientific Interests and Goals:I am interested in xylosylation of cytoplasmic proteins. My current project focused on to find out different pathways leads to production of various xylose containing glycans. I am also interested in dessecting out the role of xylose moieties on various glycan modified proteins.

First name:Ajit

Last name:Yadav


Country:India


Supervisor:Dr. Hans BakkerProf. Dr. R. Gerardy-SchahnCellular Chemistry

Faculty

Jürgen Alves Norbert Krug (Fraunhofer Institut)

Rudolph Bauerfeind Jens Kuipers

Christopher Baum Tosso Leeb (TiHo)

Rainer Blasczyk Ulrich Lehmann

Jan Buer (GBF) Robert Lindner

Olaf Dammann Nisar Peter Malek

Helmut Drexler Heiner Niemann (TiHo, Mariensee)

Matthias Eder Bernhard Schieffer

Greogor Eichele (MPI) Brigitte Schlegelberger

Reinhold Förster Reinhold Ernst Schmidt

Matthias Gaestel Jörg Schmidtke

Engelbert Gessner Thomas F. Schulz

Achim Gossler Reinhard Schwinzer

Florian Gunzer Beate Sodeik

Carlos Alberto Guzmann (GBF) Jürgen Strehlau

Hermann Haller Manfred Stuhrmann-Spangenberg

Hansjörg Hauser (GBF) Christian Trautwein

Denise Hilfiker Burkhard Tümmler

Helmut Holtmann Ernst Ungewickell

Roland Jacobs Claus Urbanke

Ingo Just Sigfried Weiss (GBF)

Andreas Kispert Karl Welte

Christoph Klein Thomas Werfel

Andreas Klos Miriam Wittmann

Alexey Kotlyarov Anna M. Wobus (IPK Gatersleben)

Department and function:Professor, Biophysical Chemistry

Education:1975 – 1981 University of Hannover, Biochemistry1981 – 1984 PhD thesis

Positions:1984 – 1990 Postdoc Hannover Medical School1990 – 1995 PD Hannover Medical School1995 - Prof. Hannover Medical School

Major research interests:Protein design using different model systems:• Restriction endonuclease EcoRI• IS1 Transposase• Helikase I• DynaminCircular Dichroism Spectroscopy

Selected Publications:Windolph S, Fritz A, Oelgeschlaeger T, Wolfes H, Alves J. Biochemistry 1997; 36: 9478-9485.Kalthoff C, Alves J, Urbanke C, Knorr R, Ungewickell EJ. J Biol Chem 2002, 277:8209-16.Scheele U, Alves J, Frank R, Duwel M, Kalthoff C, Ungewickell E. J Biol Chem. 2003; 278(28):25357-68.

First name:Jürgen

Last name:Alves

Acad. Title:Prof. Dr. rer. nat.

Address:OE 4350Hannover Medical School

Phone and e-mail:++49-0511-532 [email protected]

Further information:http://www.mh-hannover.de/institute/bpc

Department and function:Group Leader, Cell Biology

Education:1991 Dr. rer. nat. in Biology, University of Bonn

Positions:1991-94 Postdoc at EMBL + University of Heidelberg1994-97 Postdoc at Yale University School of MedicineSince 1997 Group leader at Hannover Medical School

Major research interests:Endocytosis and Signal Transduction in the Nervous SystemThe goal of our laboratory is to understand the cellular and molecular basis of communication between neurons in the mammalian nervous system.To communicate neurons use chemical signals that are stored and transported in membrane bound vesicles.Endocytosis, a fundamental process common to all eucaryotic cells, plays a central role in the formation of the vesicles. We are studying the function of endocytosis in neuronal signaltransduction and the molecular components which form endocytic transport vesicles in neurons.

Selected Publications:Bauerfeind et al. J. Biol. Chem. 1997; 272: 30984-92Bauerfeind et al. Adv. Pharmacol. 1998; 42: 253-7

First name:Rudolf

Last name:Bauerfeind

Acad. Title:Dr. rer. nat.

Address:OE4130Hannover Medical School

Phone and e-mail:++49-511 532 [email protected]

Further information:www.mh-hannover.de/institute/zellbiologie/RudisWeb/Home.htm

Department and function:Professor, Hematology and Oncology

Education:1981-1982 Philosophy 1982-1989 Medicine

Positions:1989-1991 Research Clinics, Borstel b. Bad Oldesloe1991-1992 Toxicology, Univ. of Hamburg1993-1999 Heinrich-Pette-Institute Hamburg 2000 University Hospital Eppendorf, Hamburg2000 - MHH, Dept. Hematology and Oncology2002 Cincinnati Children‘s Hospital Adjunct Position

Major research interests:Cell TherapyGene Transfer and TherapyRetrovirusesGene expressionStem Cell BiologyBiology of cell selection and clonal evolution

Oncogenesis

Selected Publications:Li Z, et al. Science 2002, 296:497.Wahlers A, et al. J Virol 2002, 76: 303-312.Schieldmeier B, et al. Blood 2003, 101:1759-1768.Baum C, et al. Blood 2003, 101:2099-2114.Williams DA, Baum C. Science. 2003; 302(5644):400-1. Engels B, et al. Hum Gene Ther. 2003; 14(12):1155-68Li Z, et al. Exp Hematol. 2003 Dec;31(12):1206-14

First name:Christopher

Last name:Baum

Acad. Title:Prof. Dr. med.Adjunct Associate Prof. of Pediatrics



Further information:www.mh-hannover.de/kliniken/haemonko/cb_research.htm

Department and function:Director, Transfusion Medicine

Education:1981-1987 Universities of Bochum and Essen, Medicine1996 Specialist in Transfusion Medicine

Positions:1987-1988 University of Marburg, Surgery1988-1991 University of Essen, Immunology1992-1993 University of Duesseldorf,

Hematology and Oncology1993-1998 Humboldt-University of Berlin,

Transfusion Medicine1998 Hannover Medical School,

Professor for Transfusion Medicine

Major research interests:MHC diversity and diversificationImmunology of allogeneic stem cell transplantationImmunology of Graft versus Host and Graft versus Tumor effects

Selected Publications:Elsner HA, Rozas J, Blasczyk R. Immunogenetics 2002; 54: 447-62.Elsner HA, Blasczyk R. Eur J Immunogenet 2002; 29: 229-36Seltsam A, Hallensleben M, Kollmann A, Blasczyk R. Blood. 2003; 102(8):3035-42. Elsner HA, DeLuca D, Strub J, Blasczyk R. Bone Marrow Transplant. 2004; 33(2):165-9. Elsner HA, Blasczyk R. Tissue Antigens. 2004; 63(2):109-21.Khattab B, Eiz-Vesper B, Ganser A, Hertenstein B, Blasczyk R. Ann Hematol. 2004; 83(2):107-13.

First name:Rainer

Last name:Blasczyk

Acad. Title:Prof. Dr.


Phone and e-mail:++49 -511- 532 [email protected]

Further information:www.mh-hannover.de/institute/transfusion

Department and function:Professor, Mucosal Immunity, GBF

Education:1987-1994 Medicine in Hannover and New York, 1995 Approbation, Doctor of Medicine, 2001 Habilitation in Immunology,

Positions:1998-present Head of Mucosal Immunity (GBF), 1998-present Institute of Medical Microbiology (MHH), 1996-1998 DFG-Fellowship in Immunology, Hôpital Necker-

Enfants Malades, Paris, France,1995-1996 Resident in Internal Medicine, Department of

Hematology and Oncology (MHH),

Major research interests:My current work on mucosal immunity concentrates on functional genomics of regulatory T cells in transgenic mouse models and patients with autoimmunity and inflammation. Other interests are Host-Pathogen-Crosstalk and Molecular Diagnostics.

Selected Publications:Buer J, AifantisI, DiSanto JP, Fehling HJ, von Boehmer H J. Exp. Med. 1997; 185:1541-1547.Buer J, Lanoue A, Franzke A, Garcia C, von Boehmer H, Sarukhan A. J. Exp. Med. 1998; 187: 177-183.Lechner O, Lauber J, Franzke A, Sarukhan A, von Boehmer H, Buer J. Curr. Biol. 2001; 11: 587-595.Buer J, Balling R. Nature Reviews Genetics 2003; 4: 195-205.Franzke A, Piao W, Lauber J, Gatzlaff P, Konecke C, et al. Blood. 2003; 102:734-9.

First name:Jan

Last name:Buer

Acad. Title:Prof. Dr. med.

Address:GBF-MIMascheroder Weg 138124 Braunschweig

Phone and e-mail:[email protected]

Further information:www.gbf.de

Department and function:Head, Perinatal Infectious Disease Epidemiology UnitObstetrics, Prenatal Medicine, and General GynecologyPediatric Pulmonology and Neonatology

Education:1981-83 Linguistics, U of Hamburg, 1983-90 Medicine, Med U of Lübeck and U of Hamburg,

Epidemiology,1996-97 Harvard School of Public Health,

Positions:1991-95 Post-Doc, Pediatrics, U of Hamburg1995-97 Post-Doc, Neuroepidemiology, Children‘s Hospital,

Boston,1997-2000 Instructor in Neurology, Harvard Med School,since 2000 Assistant Professor in Neurology, Harvard Med School, since 2002 Professor of Perinatal Infectiology, Hannover Med.

School

Major research interests:Epidemiologic research on the role of infection and inflammation in theetiology and pathogenesis of brain white matter damage in pretermnewborns

Selected Publications:Dammann O, Leviton A. Pediatric Research 1997;42:1-8.Dammann O, Leviton A. Current Opinion in Pediatrics 2000;12:99-104.Dammann O, Durum S, Leviton A. Trends in Neurosciences 2001; 24:320-4.Dammann O, Allred EN, Genest DR, Kundsin RB, Leviton A. Paediatric and Perinatal Epidemiology 2003;17:49-57.Dammann O, Drescher J, Veelken N. Developmental Medicine & Child Neurology 2003;45:148-51.Jung H, Neumaier Probst E, Hauffa BP, Partsch CJ, Dammann O. J Clin Endocrinol Metab. 2003 Oct;88(10):4590-5. Dammann O, Leviton A. Ann Neurol. 2004 Feb;55(2):158-161.Dammann O, Allred EN, Van Marter LJ, Dammann CE, Leviton A. Pediatr Res. 2004; 55(2):319-325.

First name:Olaf

Last name:Dammann

Acad. Title:Prof. Dr.med., M.Sc.


Phone and e-mail:++49-511- 532 [email protected]

Further information:http://www.mh-hannover.de/forschung/perinatalinfektiologie/index.htm

Department and function:Director, Cardiology and Angiology

Education:1970 – 1976 Medical School, Univ. of Freiburg1986 Habilitation

Positions:1989-1996 Associate Professor University of Freiburg1990 – 1994 Heisenberg Award and InvestigatSept. 1996 Professor of Medicine, Chief of Cardiology, Medical

University, Hannover

Major research interests:Endothelial FunctionMolecular Mechanisms of cardiac hypertrophy and adaption to stressInflammation in arteriosclerosi

Selected Publications:Schieffer B, Schieffer E, Hilfiker-Kleiner D, Hilfiker A, Kovanen PT, et al. Circulation. 2000 Mar 28;101(12):1372-8.Schieffer B, Luchtefeld M, Braun S, Hilfiker A, Hilfiker-Kleiner D, et al. Circ Res. 2000; 87(12):1195-201Fiedler B, Lohmann SM, Smolenski A, Linnemüller S, Pieske B, et al. Proc Natl Acad Sci USA 2002;99:11363-11368Hornig B, Kohler C, Schlink D, Tatge H, Drexler H. Hypertension 2003; 41(5):1092-5Spiekermann S, Landmesser U, Dikalov G, Bredt M, Gamez G, et al. Circulation 2003; 107: 1383 - 1389Heineke J, Kempf T, Kraft T, Hilfiker A, Morawietz H, et al. Circulation 2003; 107: 1424 - 1432Podewski E.K., Hilfiker-Kleiner D., Hilfiker A., Morawietz H., Lichtenberg A., et al. Circulation 2003; 107: 798-802Schieffer B, Drexler H. J Am Coll Cardiol. 2003;41(11):1962-3.Wollert KC, Drexler H. Eur Heart J. 2003; 24(24):2164-5.

First name:Helmut

Last name:Drexler



Phone and e-mail:++49- 511- 532 [email protected]

Further information:www.mh-hannover.de/kliniken/kardiologie/index.html

Department and function:Professor, Hematology/Oncology unit; Consultant Bone marrow transplantation

Education:1982-89 Study of Medicine, Homburg/S and

Frankfurt/M1990 Doctoral thesis1989-91 Research assistant and fellow Int. Med.1991-93 Research fellow Dana Farber Cancer Inst., Boston1993-2000 Research fellow Int. Med. Frankfurt + MHHSince 2001 Habilitation, consultant Int. Medicine

Positions:1991-1993 Dana Farber Cancer Institute, Boston1993-1996 Johann Wolfgang v.Goethe University

FrankfurtSince 1996 MHH

Major research interests:Signal transduction by cytokine receptors in myeloid cellsModels for myeloproliferative disorders and acuteleukemiaLentiviral gene transferRNA interference

Selected Publications:Kafert S, Luther S, Böll I, Wagner K, Ganser A, Eder M. J.Biol. Chem 1999. 274:33064Wagner K, Kafert-Kasting S, Heil G, Ganser A, Eder M. Blood 2001, 98: 2681Scherr M, Battmer K, Blömer U, Schiedlmeier B, Ganser A, Grez M, Eder M. Blood2002, 99:709Scherr M, Battmer K, Winkler T, Heidenreich O, Ganser A, Eder M.. Blood 2003,101:1566Scherr M, Morgan MA, Eder M. Curr Med.Chem 2003, 10: 245Tiede A, Eder M, von Depka M, Battmer K, Luther S, et al. Gene Ther. 2003; 10(22):1917-25. Scherr M, Steinmann D, Eder M. Ann Hematol. 2004; 83(1):1-8.

First name:Matthias

Last name:Eder




Further information:http://www.mh-hannover.de/kliniken/haemonko/index.htm

Department and function:Director, Molecular Embryology, MPI

Education:1980 Ph.D. University of Basel1981-1984 Postdoctoral training University of California,

San Francisco

Positions:1985-1989 Assistant Professor, Harvard Medical School, Boston1989-1990 Associate Professor, Harvard Medical School, Boston1991-1992 Associate Professor, Baylor College of Medicine,

Houston1992- Professor of Biochemistry and Neuroscience,

Baylor College of Medicine,Houston1997 A. Romansky Professor of Biochemistry1998- Director at the Max-Planck-Institute of Experimental

Endocrinology, Hannover

Major research interests:Developmental BiologyFunctional GenomicsNeurobiologyCircadian rhythms

Selected Publications:Sun ZS, Albrecht U, Zhuchenko O, Bailey J, Eichele G, LeeCC. Cell 1997; 90: 1003-1011.Albrecht U, Sun Z, Eichele G, Lee CC. Cell 1997; 91: 1055-1064.Reymond A, Marigo V, Yaylaoglu MB, Leoni, A, Ucla C, et al. Nature 2002;420: 582-586.Carson JP, Thaller C, Eichele G Current Opinion in Neurobiology 2002;12: 562-565.Moeller C, Swindell EC, Kispert A, Eichele G. Development. 2003;130(21):5103-11. Visel A, Thaller C, Eichele G. Nucleic Acids Res. 2004 Jan 1;32

First name:Eichele

Last name:Gregor

Acad. Title:Prof. Dr. Phil.

Address:Max-Planck Insitutefor Experimental Endocrinology,Hannover

Phone and e-mail:++49-511- 5359 [email protected]

Further information:http://www.endo.mpg.de/

Department and function:Director, Immunology

Education:1981 Abitur, Gymnasium Pegnitz1988 DVM, Munich, Veterinary Faculty1988 - 1991 Ph.D. Thesis

Positions:1991-93 Postdoc, Insitute of Biochemistry, University of Munich1994-00 Research Associate, Max-Delbruck-Center for

Molecular Medicine, Berlin2000-01 Associate Professor for Experimental Surgery and

Immunology, University of Erlangen2001 – Director and Head, Institute of Imunology, Professor for

Immunology

Major research interests:Chemokines and chemokine receptors, role in lymphoid organorganogenesis and organization, development of immunology memory,cell migration, tumor metastasis

Selected Publications:Forster R., Mattis A. E., Kremmer E., Wolf E., Brem G., Lipp M. Cell 1996 87:1037Forster R., Schubel A., Breitfeld D., Kremmer E., Renner-Muller I., et al. Cell 199999:23 Breitfeld D., Ohl L., Kremmer E., Ellwart J., Sallusto F., et al. J Exp Med 2000192:1545Henning G., Ohl L, Junt T., Reiterer P., Brinkmann V., et al. J Exp Med 2001;194:1875Ohl L., Henning G., Krautwald S., Lipp M., Hardtke S., et al. J Exp Med 2003;197:1199Pabst O., Ohl L., Wendland M., Wurbel M.A., Kremmer E., et al. J Exp Med. 2004

First name:Reinhold

Last name:Förster

Acad. Title:Prof. Dr. med. vet



Department and function:Director, Biochemistry (Physiological Chemistry)

Education:1983 PhD in Biology (Biophysics), Humboldt-University

Berlin1993 Habilitation in Biochemistry, Free University Berlin

Positions:1991-1995: Junior Research Group Leader at the Max-Delbrück-

Centrum for Molecular Medicine (MDC), Berlin-Buch1995-1997: Heisenberg-Fellow of the German Research Council

(DFG), Guest Research Group Leader at the MDC,Berlin-Buch

1997-2000: Professor of Molecular Genetics; Innovationskolleg"Zellspezialisierung" of the Martin-Luther-UniversityHalle-Wittenberg

2001-recent: Chair and Head of Institute of Biochemistry/ Physiological Chemistry of Hannover Medical School

Major research interests:Analysis of mechanisms of stress-dependent signal transductionNucleo-cytoplasmic signallingRegulation of gene expression by protein phosphorylation at the post-transcriptional level

Selected Publications:Kotlyarov A., Neininger A., Schubert C., Eckert R., Birchmeier C., et al. Nature Cell Biol. 1999; 1: 94-97.Neininger A., Thielemann H, Gaestel M. EMBO Rep. 2001; 2: 703-708.Neininger A., Kontoyiannis D., Kotlyarov A., Winzen R., Eckert R., et al. J. Biol. Chem. 2002; 277: 3065-3068.Kotlyarov A., Yannoni Y., Fritz S., Laaß K., Telliez J.-B., et al. Mol. Cell. Biol. 2002; 22: 4827-4835.Shi Y, Kotlyarov A, Laabeta K, Gruber AD, Butt E, et al. Mol Cell Biol. 2003; 23(21): 7732-7741.

First name:Matthias

Last name:Gaestel




Further information:www.mh-hannover.de/institute/biochemie

Department and function:Group Leader, Laboratory of Molecular Immunology; ClinicalImmunology

Education:1993 PhD in Chemistry and Molecular Biology, Technical

University (TU) Berlin1999 Habilitation in Immunology, Hannover Medical School

Positions:1994-1996: Research Associate, Dept. of Clinical Immunology,

Hannover Medical School 1994: Visiting Scientist, Dept. of Immunology, University of

Utrecht, The Netherlands1997: EMBO Research Fellow, Dept. of Pathology, CMU

Geneva, Switzerland1997-recent: Research Group Leader, and from 2002 on, Scientific

Director and Head of the Laboratory of Molecular Immunology at the Department of Clinical Immunology, Hannover Medical School

Major research interests:I) Analysis of molecular mechanisms underlying immunoregulation during disease development in gene knockout mice.II) Signal transduction of G-protein coupled receptors.III) Gene regulation of IgG Fc receptors and their targeting for the establishment of new therapeutic strategies.

Selected Publications:Meyer D. et al. Blood 1998; 92:2997-4002.Schiller C. et al. Eur J Immunol. 2000; 30:481-490.Baumann U. et al. J Immunol. 2000; 164:1065-1070.Baumann U. et al. J Immunol. 2001; 167:1022-1027.Chouchakova N. et al. J Immunol. 2001; 166:5193-5200.Heusohn F. et al. J Immunol. 2002; 168:2857-2864.Radeke HH. et al. J Biol Chem. 2002; 277:27535-27544.Shushakova N. et al. J Clin Invest. 2002; 110:1823-1830.Nieswandt B. et al. Int Immunol. 2003; 15:341-349.

First name:J. Engelbert

Last name:Geßner

Acad. Title:Prof. Dr. rer.nat.Dr. hum.biol.habil.



Further information:www.mh-hannover.de/kliniken/immun

Department and function:Director, Molecular Biology

Education:1982 B.S. Eberhard-Karls-University, Tübingen,) 1983 M.S. Friedrich-Miescher-Laboratory (FML) of

the Max-Planck-Society, Tübingen1986 Ph.D. Max-Planck-Society, Tübingen1987 - 1989 Postdoc at the Mount Sinai Hospital Res.

Institute, Toronto, Canada

Positions:June 1989- July 1994 Head of an independent research group at

Max-Delbrück-Lab., Cologne, GermanyApril 1994 Habilitation: University of Cologne Aug. 1994 - July 1997 Associate Staff Scientist, The Jackson

Laboratory, Bar Harbor, MEAug. 1997 - June 1999 Staff Scientist , The Jackson Laboratorysince July 1999 Professor for Molecular Biology, MHH

Major research interests:The main research interest of the group lies on the analysis of the molecular mechanisms underlying developmental processes during mammalian embryogenesis. Development of the Notochord The notochord is a transient embryonic structure that serves as a signaling center that is essential for the dorsoventralpatterning of the spinal cord and somites. Various mutations in mice disturb the development or maintenance of the notochord. Identification and functional characterization of the genes affected by these mutations is the subject of several projects. Somitogenesis Somites form as the result of segmentation of the paraxial mesoderm. They give rise to the vertebrae, ribs, the epaxial and hypaxialmuscles and the dorsal dermis. Their formation lays the basis for the metameric arrangement of the vertebrae and of the spinal ganglia. The formation of segments as well as their subdivision into cranial and caudal compartments is the subject of our investigations. We analyse the role of Notch signalling in these processes as well as spontaneous mouse mutants in which somitogenesis is disrupted.

Selected Publications:Jouve C., Palmeirim I., Henrique D., Beckers J., Gossler A., et al. Development 2000; 127: 1421-1429.Beckers J., Schlautmann N., Gossler, A. MOD 2000; 95: 35-46.Beckers J, Caron A, Hrabê de Angelis M, Hans S, Campos-Ortega JA, Gossler A.MOD 2000; 95: 23-34.Watabe-Rudolph M, Schlautmann N, Papaioannou VE, Gossler A. MOD 2002; 119:251-256Aulehla A, Wehrle C, Kemler R, Mallo M., Gossler A., Kanzler B, Herrmann BG. Dev. Cell 2003; 4: 395-406Serth K, Schuster-Gossler K, Cordes R, Gossler A.Genes and Development 2003; 17(7):912-25

First name:Achim

Last name:Gossler




Further information:http://www.mh-hannover.de/institute/molekularbiologie/

Department and function:Group Leader, Medical Microbiology

Education:1983 – 1990 Medical School in Würzburg, Bonn and Köln1991 – 1993 MD thesis

Positions:1994 – 1996 Postdoc, Tufts University, BostonFrom 1996 Research associate, Institute of Medical Microbiology,


Major research interests:-Virulence of enterohemorrhagic E. coli and pathogenicity of EHEC-infections-Microbe/host interactions in EHEC-disease-Development of diagnostic tools for detection of bacterial pathogens

Selected Publications:Gunzer F, Hennig-Pauka I, Waldmann KH, Sandhoff R, Gröne HJ, et al. Am.J.Clin.Pathol. 2002; 118:364-375.Gunzer F, Hennig-Pauka I, Waldmann KH, Mengel M. Methods Mol.Med. 2003;73:307-327.Pulz M, Matussek A, Monazahian M, Tittel A, Nikolic E, et al. J Clin Microbiol. 2003; 41(10):4671-5. Matussek A, Lauber J, Bergau A, Hansen W, Rohde M, et al. Blood. 2003; 102(4):1323-32

First name:Florian

Last name:Gunzer

Acad. Title:MD (Dr. med.)



Further information:http://www.mh-hannover.de/institute/mikrobiologie/

Department and function:Head Vaccine Research Group, Microbial Pathogenesis and Vaccine Research, Division of Microbiology, GBF

Education:1976-1981 Medicine, National University Rosario, Argentina1982-1986 Specialisation in Bacteriology, Rosario, Argentina 1988 MD, University of Genoa, Italy1989 Qualifying Medical Graduates Examination, School of

Medicine and Surgery, Genoa, Italy1993 PhD in Microbiology, University of Genoa, Italy2000 Habilitation Medical Microbiology, Hanover Medical

School

Positions:Since 1994 Head Vaccine Research, GBF, Braunschweig, Germany1991 - 1993 Laboratory of Microbial Pathogenesis, Univ. Genoa, Italy1989 - 1991 Division of Microbiology, GBF, Braunschweig, Germany1986 - 1989 Institute of Microbiology, Genoa, Italy1982 - 1986 National University of Rosario, Argentina1982 - 1986 Italian Hospital, Rosario, Argentina1982 - 1986 Children Hospital, Rosario, Argentina

Major research interests:Vaccinology, mucosal immunity, development of antigen delivery systems and adjuvants.

Selected Publications:Guzmán C A, Talay S R, Molinari G, Medina E., Chhatwal GS. J. Infect. Dis 1999;179:901-906.Medina E, Molinari G, Rohde M, Hasse B, Chhatwal GS, Guzmán CA. J. Immunol. 1999; 163:3396-3402.Medina E, Paglia P, Rohde M., Colombo M.P, Guzmán CA. Eur. J. Immunol. 2000;30:768-777.Drabner B, Borsutzky S, Winckler U, Morr M, Ensoli B, et al. Eur. J. Immunol. 2002; 32:2857-2865Schulze K, Medina E, Chhatwal GS, Guzman CA. Vaccine. 2003; 21:1958-64. Borsutzky S, Fiorelli V, Ebensen T, Tripiciano A, Rharbaoui F, et al. Eur J Immunol. 2003 Jun;33(6):1548-56. Schulze K, Medina E, Chhatwal GS, Guzman CA. Infect Immun. 2003; 71(12):7197-201.

First name:Carlos Alberto

Last name:Guzman

Acad. Title:MD, PhD

Address:GBFMascheroder Weg 138124-Braunschweig


Department and function:Director, Nephrology; Chairman, Department of Internal Medicine

Education:1972-1982 Chemistry, Art History, Medicine in

Tübingen, Berlin and Cardiff

Positions:1992-1996 Assistenzarzt FU Berlin1996-1999 Postdoctoral Fellowship Yale University1992-1997 Professor of Medicine, Franz-Volhard-Klinik

at the Max Delbrück Centre, Berlin1999 Professor of Medicine, MHH

Major research interests:I am interested in acute and chronic changes of the vasculature. I have started in analysing signal transduction pathways in vascular smooth muscle cells and gradually moved into endothelial cells. Additionally, I am interested in vascular development, circulating endothelial progenitor cells and stem cells in the kidney.

Selected PublicationsMaasch C, Wagner S, Lindschau C, Alexander G, Buchner K, et al. FASEB J 2000; 14(11):1653-1663.Drab M, Verkade P, Elger M, Kasper M, Löhn M, et al. Science 2001; 293 (5539): 2449-2452.Radermacher J, Chavan A, Bleck J, Vitzthum A, Stoess B, et al. N Engl J Med. 2001; 344(6):410-417.Woywodt A, Streiber F, de Groot K, Regelsberger H,Haller H, Haubitz M. Lancet2003; 361(9353):206-210.Radermacher J, Mengel M, Ellis S, Stuht S, Hiss M, et al. N Engl J Med. 2003; 349(2):115-24Woywodt A, Schroeder M, Gwinner W, Mengel M, Jaeger M, et al. Transplantation. 2003; 76(1):1-4Fiebeler A, Park JK, Muller DN, Lindschau C, Mengel M, et al. Am J Kidney Dis. 2004 Feb;43(2):286-95

First name:Hermann

Last name:Haller




Further information:[email protected]

Department and function:Head, Gene Regulation and Differentiation And Division of Molecular Biotechnology, GBF

Education:1969-1974 University of Stuttgart-Hohenheim, Food technology1974-1977 PhD thesis at University of Konstanz, Biology

Positions:1978-1980 Post-Doc at MPI f. Molecular Genetics, Berlin and

DKFZ, Heidelberg1981- Research fellow, group leader, head of dept.,

head of division, GBF, Braunschweig

Major research interests:1. Signal transduction in the cytokine system (signalling molecules

and their impact on transcription, cellular and systemic consequences)

2. Biotechnology with mammalian cells (protein production, viral vectors, cellular vaccines)

Selected Publications:Kirchhoff S., Hauser H. Oncogene 1999; 18: 3725-3736Nourbakhsh M, Hauser H. EMBO J. 1999; 18:101-111Kröger A, Ortmann D, Krohne TU, Blum H., Hauser H, Geissler M. Cancer Res.2001, 61, 2609-2617Unsinger J, Kröger A, Hauser H, Wirth D. Molecular Therapy 2001; 4: 484-489Meraro D, Gleit-Kielmanowicz M, Hauser H, Levi B-Z. J. Immunology 2002; 168:6224-6231Feng X, Guo Z, Nourbakhsh M, Hauser H, Ganster R, et al. Proc. Natl. Acad. Sci.USA 2002, 99: 14212-14217Kröger A, Dallügge A, Kirchhoff S., Hauser H. Oncogene 2003, 22:1045-1056

First name:Hansjörg

Last name:Hauser

Acad. Title:Dr. rer. nat

Address:GBFMascheroder Weg 138124 Braunschweig

Phone and e-mail:++49 [email protected]

Further information:www.gbf.de

Department and function:Group Leader, Molecular Cardiology (Cardiology and Angiology)

Education:1994 PhD in Biology (Genetics and Developmental Biology),

University of ZürichZürich, CH

Positions:1994-1996: Post Doc in the Department of Biology at the EMORY University in Atlanta (Georgia, USA)1997-2001: Post Doc in the Department of Cardiology and

Angiology of Hannover Medical School2001-recent: Group Leader in Molekular Cardiology in the

Department of Cardiology and Angiology

Major research interests:Analysis of mechanisms of stress-dependent signal transductionresponsible for the transition of compenatory hypertrophy todecompensated hypertrophy in the heart. Focus on the gp130-JAK/STAT signaling pathway and AP-1 transcription factors.Regulation and role of pro-angiogenic gene CCN1 in the pathophysiology of the heart.

Selected Publications:Hilfiker A., Hilfiker-Kleiner D., Pannuti A., Lucchesi J. C.. EMBO J. 1997; 16: 2054-2060

Hilfiker-Kleiner D, Hilfiker A, Schieffer B, Engel D, Mann DL, Wollert KC, DrexlerH Cardiovasc Res. 2002; 53(2):460-469.

Hilfiker A., Hilfiker-Kleiner D., Fuchs M., Kaminski K., Lichtenberg, A., RothkötterH., Schieffer B., and Drexler H. Circulation. 2002; 106(2):254-260

Podewski E.K., Hilfiker-Kleiner D., Hilfiker A., Morawitz H., Lichtenberg A., Wollert K.C. and Drexler H. Circulation. 2003Hilfiker-Kleiner D, Kaminski K, Kaminska A., Fuchs M., Klein G., Podewski E.,Kiian I., Wollert K.C., Hilfiker A., Drexler H. Circulation accepted for publication

First name:Denise

Last name:Hilfiker-Kleiner

Acad. Title:PhD



Further information:www.mh-hannover.de/cardiology

Department and function:Professor, Biochemistry (Physiological Chemistry)

Education:1980 Diploma in Biology, University of Hannover1985 Ph. D., Ludwig-Maximilians-University Munich1993 Habilitation in Immunology, Medical School Hannover

Positions:1985-1987: Postdoctoral fellow at the Weizmann Institute of

Science, Rehovot, Israel1987-2001: Group leader, Institute of Pharmacology, Medical

School Hannover2001-2003: GBF-BraunschweigSince 2003: Professor for Biochemistry of Cellular Signal

Transduction, Institute of Biochemistry/Physiological Chemistry, Medical School Hannover

Major research interests:Post-transcriptional control of gene expression in inflammation

- cis-acting RNA elements- regulatory RNA-binding proteins- signalling pathways affecting post-transcriptional mechanisms

Selected Publications:Winzen R., Kracht M., Ritter B., Wilhelm A., Chen C.-Y.A., Shyu A.-B., Müller M., Gaestel M., Resch K., Holtmann. H. EMBO J. 1999; 18:4969-4980.Holtmann H., Winzen R., Holland P., Eickemeier S., Hoffmann E., Wallach D., Malinin N., Cooper J.A., Resch K., Kracht M. Mol. Cell. Biol. 1999; 19:6742-6753.Bollig F., Winzen R., Kracht M., Ghebremedhin B., Ritter B., Wilhelm A., Resch K., Holtmann H. Eur. J. Biochem. 2002; 269:5830-5839.Winzen R., Gowrishankar G., Bollig F., Redich N., Resch K., Holtmann H. Mol. Cell. Biol. 2004, in press.

First name:Helmut

Last name:Holtmann




Further information:www.mh-hannover.de/institute/biochemie

Department and function:Group Leader, Clinical Immunology

Education:1981-1986 Biology in Hannover

Positions:1987-recent Scientist in the Division of Clinical Immunology, MHH1992 PhD in Biology, MHH2003 Habilitation in Immunology, MHH

Major research interests:Analysis of Natural Killer (NK) cell subpopulations. Our particular interest is focused on NK cells with weak cytoxic capacity that are supposed to play an important role in immune regulation.

Selected PublicationsR. Jacobs, G. Hintzen, A. Kemper, K. Beul, G. Behrens, S. Kempf, K. W. Sykora und R. E. Schmidt. Eur J Immunol 2001; 31: 3121-3126.

R. Jacobs, C. R. Pawlak, E. Mikeska, D. Meyer-Olson, M. Martin, C. J. Heijnen, M. Schedlowski und R. E. Schmidt. Rheumatol 2001; 40: 868-875.

J. M. Kittner, R. Jacobs, C. R. Pawlak, C. J. Heijnen, M. Schedlowski und R. E. Schmidt. Rheumatol 2002; 41: 1031-1039.

R. H. Straub, J. M. Kittner, C. J. Heijnen, M. Schedlowski, R. E. Schmidt und R. Jacobs. J Rheumatol 2002; 29: 1659-1664.

R. Jacobs, H. Heiken und R. E. Schmidt. Mol Immunol 2004; in press:

R. Jacobs, K. Weber, K. Wendt, H. Heiken und R. E. Schmidt. J Clin Immunol 2004; in press

First name:Roland

Last name:Jacobs

Acad. Title:PD Dr.



Further information:www.mh-hannover.de/kliniken/immun

Department and function: Director, Toxicology

Education:1976-1988 Pharmacy in Münster

Medicine at Free University Berlin

Positions:1989-1995 Postdoc positions in Pharmacology at the Universities

of Giessen, Essen, Homburg/Saar1997 Post Orange Fellowship of INSERM in Nice, France1995-2000 Assistant Professor at the University of Freiburg2000 Professor of Toxicology, MHH

Major research interests:The molecular and cellular mode of action of bacterial protein toxins and the functional consequences on the signal transduction of the target cells.

Selected Publications

Vetter, IR, Hofmann, F, Wohlgemut, S, Herrmann, C, Just, I. J. Mol. Biol. 2000; 301:1091-1095Wilde, C, Chhatwal, GS, Schmalzing, G, Aktories, K, Just, I. J. Biol. Chem 2001;276:9536-9542Wilde, C, Barth, H, Sehr, P, Han, L, Schmidt, M, Just, I, Aktories, K J. Biol. Chem. 2002; 277:14771-14776Gerhard, R, John, H, Aktories, K, Just, I Mol. Pharmacol. 2003; 63:1349-1355Genth H, Gerhard R, Maeda A, Amano M, Kaibuchi K, Aktories K, Just, I. J. Biol: Chem. 2003; 278: 28523-28527Ahnert-Hilger G, Höltje M, Große G, Pickert G, Mucke C, Nixdorf-Bergweiler B, Boquet P, Hofmann F, Just I. J. Neurochem. 2004, in press

First name:Ingo

Last name:Just

Acad. title:Prof. Dr.



Further information:http://www.mh-hannover.de/

institute/toxikologie/

Department and function:Professor, Molecular Biology of Vertebrates

Education:1983-1989 University of Tübingen, Biochemistry1987-1988 Queen Mary College, London, Biochemistry1989-1990 Diploma thesis, MPI Tübingen1990-1993 PhD thesis, MPI Tübingen

Positions:1993-1994 Postdoc, MPI Tübingen1994-1996 Postdoc, Harvard University1997-2001 Group leader, MPI FreiburgSince 2001 C3 Professor, MHH

Major research interests:Genetic control of vertebrate (mouse) development:- Organogenesis (organs of mesodermal origin like kidneys, skeleton,muscles, heart)

- Function of Wnt and Tbx genes in development

Selected Publications:Kispert A, Vainio S, McMahon AP. Development 1998; 125: 4225-4234Herrmann BG, Koschorz B, Wertz K, McLoughlin KJ, Kispert A. Nature 1999; 402: 141-146Leitges M, Neidhardt L, Haenig B, Herrmann BG, Kispert A. Development 2000; 127: 2259-2267Kohlhase J, Heinrich M, Liebers M, Frohlich Archangelo L, Reardon W, Kispert A. Cytogenet Genome Res. 2002; 98(4):274-7Moeller C, Swindell EC, Kispert A, Eichele G. Development. 2003; 130(21):5103-11.

First name:Andreas

Last name:Kispert




Further information:http://www.ifm-mhh.de.vu/

Department and function:Professor; Pediatric Hematology/Oncology

Education:1983-1990 Medical School (University Ulm, Munich)1992 Magister Artium, Philosophy2000 Doctorat Immunology (Institut Pasteur, Paris)

Positions:1990 Residency in Pediatrics, University Munich1991-1994 Residency and Research Associate Hôpital Necker

Enfants Malades, Paris1994-1995 Residency in Pediatrics, University Freiburg1995-1998 Clinical and Research Fellow

Children‘s Hospital, Harvard Medical School Boston1998-2000 Instructor in Pediatrics and Research Associate, Howard

Hughes Medical Instit., Harvard Medical School, Boston2000- Hannover Medical School

Major research interests:Gene Therapy, Tumor Immunology, Stem Cell Biology

Selected Publications:Klein C, Bueler H, Mulligan RC. J Exp Med 2000; 191: 1699-1708Dahl AM, Klein C, Andres PG, London CA, Lodge MP, et al.. J Exp Med 2000,191:2031-2038Snapper SB, Takeshima F, Rosen FS, Antón I, Thomas S, et al. Nat Cell Biol 2001;3:897-904Robert C, Klein C, Cheng G, Kogan A, Mulligan RC, et al. Gene Therapy 2003; 10(17):1479-86Klein C, Nguyen D, Liu CH, Mizoguchi E, Bhan AK, Rosen FS, et al. Blood 2003; 101(6):2159-66

First name:Christoph

Last name:Klein

Acad. Title:Prof. Dr., PhD


Phone and e-mail:+49-511-532 [email protected]

Further information:www.mh-hannover.de/Kliniken/paed_haemonko/Klinik.htm

Department and function:Assistant Medical Director, Medical Microbiology

Education:1980 - 86 Study of Medicine at the Johannes-Gutenberg University

Mainz1988 - 91 Experimental training in Molecular Biology and Cell

Biology at the Baylor College of Medicine, Department ofCell Biology, Houston, Texas, Medical Center

2000 Consultant with board certification in Med. Microbiol.

Positions:1987 - 88 Research Assistent in the Department of Medical

Microbiology, Johannes-Gutenberg University, Mainz1991 -2000 Research Assistant and, from 2001 on, Assistant Medical

Director at the Department of Medical Microbiology, MHH

Major research interests:Basic research on …1. Chlamydia: Bacteria–host-cell interaction, regulated host-cell genes, mechanisms and signalling pathways2. Complement: Anaphylatoxic peptides C3a, C5a and their G-proteincoupled receptors as part of the innate immunity, receptor regulation on various levels including gene-regulation and interaction with cytokines

Selected Publications:Hess S., et al.. Arthritis Rheum. 2001; 44: 2392-2401Settmacher B., et al. Eur J Immunol. 2003; 33: 920-927Hess S, et al. Cell Microbiol. 2003; 5(11):785-95.

First name:Andreas

Last name:Klos




Further information:www.mh-hannover.de/institute/mikrobiologie/

Department and function:Group Leader, Biochemistry (Physiological Chemistry)

Education: 1978-1985 Medical School, Charkov, Ukraine1987-1991 PhD thesis

Positions:Research Assistent

Major research interests:MAPK cascades activated by stress or cytokinesSignalling events that are triggered by p38 activity,and analyse how these events contribute to specific gene expression and cellular responses.

Selected Publications:Kotlyarov A., Neininger C., Schubert R., Eckert C., Birchmeier H-D, et al. Nature Cell Biol. 1999; 1: 94-97.Kotlyarov A, Gaestel M. Biochem. Soc. Trans. 2002; 30: 959-963.Kotlyarov A, Yannoni Y, Fritz S, Laaß K, Telliez J-B, et al. Mol. Cell. Biol. 2002; 22: 4827–4835.Shi Y, Kotlyarov A, Laabeta K, Gruber AD, Butt E, et al. Mol Cell Biol. 2003; 23(21):7732-41.

First name:Alexey

Last name:Kotlyarov

Acad. Title:MD



Further information:www.mh-hannover.de/ institute/biochemie/

Department and function:Head of Immunology, Allergology and Clinical Inhalation Research, ITEM

Education:1981-89 Medicine in Hannover, Göttingen and Hartford (USA)1998-2000 Degree in Internal Medicine, Respiratory Medicine,

Allergology and Intensive Care Medicine, Hannover Medical School (MHH)

1999 Habilitation in Internal Medicine (MHH)

Positions:1989-93 and1995-2000: Assistenzarzt Medical School Hannover (MHH)1993-95: Postdoctoral Fellowship University Bochum and

University Southampton (German Research Council Scholarship)

since 2000: Professor of Immunology, Allergology and Clinical Inhalation Research, MHHand Head of Department Immunology, Allergology and Clinical Inhalation Research, Fraunhofer ITEM

Major research interests:Pathophysiology and therapeutic interventions of airway diseases, in particular asthma. Preclinical and clinical research.

Selected Publications:Krug N, Erpenbeck VJ, Balke K, Petschallies J, Tschernig T, et al. Am J Respir Cell Mol Biol 2001;25:125-131.Krug N, Tschernig T, Erpenbeck VJ, Hohlfeld JM, Köhl J. Am J Respir Crit Care Med 2001;164:1841-1843. 29.Erpenbeck VJ, Hohlfeld JM, Volkmann B, Hagenberg A, Geldmacher H, et al. J Allergy Clin Immunol 2003; 111: 1319-27.Nassenstein C, Braun A, Erpenbeck VJ, Lommatzsch M, Schmidt S, et al. J Exp Med 2003; 198; 455-67.Erpenbeck VJ, Hagenberg A, Dulkys J, Elsner J, Krentel H, et al. Am J Respir Crit Care Med 2004; 169; 578-586.Hohlfeld JM, Schmiedl A, VJ Erpenbeck, Venge P, Krug N. J Allergy Clin Immunol 2004; 113: 496-502.Weigt H, Muhlradt P, Larbig M, Krug N, Braun A. J Immunol 2004 (in press).

First name:Norbert

Last name:Krug


Address:Fraunhofer Institute forToxicology and Experimental Medicine Nikolai-Fuchs-Str. 130625 Hannover


Further information:www.item.fraunhofer.de

Department and function: Group Leader, Rheumatology,Consultant for Internal Medicine and Rheumatology

Education:1984-1991 Study of medicine at Hannover Medical School

Positions:1991-1993 Physician in practive/fellow Hannover Medical School1993-1995 Postdoctoral Fellowship

University of California Los Angeles1993-2000 Fellow in the Department of Internal Medicine at

Hannover Medical School2000 Consultant for Internal Medicine2001 Consultant for Rheumatology

Major research interests:I am interested in the etiopathogenesis, genetics and diagnosis of undifferentiated and reactive arthritis & spondyloarthritis: • analysis of mechanisms of bacterial persistence, • the development of optimized diagnostic tools to discover

intraarticularly persisting bacteria, • identification of genetic susceptibility factors of arthritis.

Selected publications:Kuipers, J.G., Bialowons, A., Dollmann, P., Jendro, M.C., Koehler, et al. Clin. Exp.Rheumatol., 2001, 19:47-52.Seta, N., Granfors, K., Sahly, H., Kuipers, J.G., Song, Y.W., et al. Arthritis Rheum.; 2001; 44:931-939.Putschky, N., Schnarr, S., Wollenhaupt, J., Zeidler, H., Kuipers, J.G. Ann Rheum Dis2001; 60:632-634.Schnarr, S., Putschky, N., Jendro, M.C., Zeidler, H., Hammer, M., Kuipers, J.G.,Wollenhaupt, J. Arthritis Rheum. 2001; 44: 2679-2685. Kuipers, J.G., Andresen, J., Köhler, L. Schnarr, S., Putschky, N., Zeidler, H.,Wollenhaupt, J. Clin Exp Rheumatol. 2002, 20:185-192.Kuipers, J.G., Bialowons, A., Dollmann, P., Jendro, M.C., Wagener, N., Rebmann, V., et al. Clin. Exp. Rheumatol. 2002, 20:455-462Jendro, M.C., Fingerle, F., Deutsch, T., Liese, A., Köhler, L., et al. Med. Microbiol.Immunol 2004 193: 45-52

First name:Jens

Last name:Kuipers

Acad. Title:Priv.-Doz. Dr. med.



Further information:http://www.mh-hannover.de/kliniken/rheumatologie/

Department and function:Professor, Animal Breeding and Genetics, TiHo

Education:1987-1992 Diplom, Chemistry, University of Munich1993-1995 PhD thesis, Biochemistry, U. of Munich

Positions:1996 Postdoc, UTHSC, San Antonio, Tx, USA1996-1999 Postdoc (Habilitation), U. of Göttingen

Major research interests:Molecular genetics and genomics of domestic animals (dog, horse, pig, cattle)Identification of genetic variations that lead to hereditary diseases or other phenotypic traits such as economically important performance traits

Selected Publications:Drögemüller C, Distl O, Leeb T. Genome Res 2001; 11: 1699-1705.Drögemüller C, Peters M, Pohlenz J, Distl O, Leeb T. J Mol Med 2002; 80: 319-323.Martins-Wess F, Voß-Nemitz R, Drögemüller C, Brenig B, Leeb T. Genomics 2002; 80: 416-422.Backofen B, Jacob R, Serth K, Gossler A, Naim HY, Leeb T. Eur J Biochem. 2002; 269(21):5240-5. Martins-Wess F, Milan D, Drogemuller C, Vobeta-Nemitz R, Brenig B, et al. BMC Genomics. 2003; 4(1):20. Sander P, Hamann H, Pfeiffer I, Wemheuer W, Brenig B, et al. Neurogenetics. 2004

First name:Tosso

Last name:Leeb


Address:Department of AnimalBreeding and GeneticsSchool of VeterinaryMedicine HannoverBünteweg 17p30559 Hannover


Further information:www.tiho-hannover.de/ einricht/zucht/t_leeb.htm

Department and f unction:Group Leader and Head of the Laboratory of Molecular Diagnostics; Pathology

Education:1986-1992 University of Hannover, Biochemistry1992-1996 PhD, Molecular Biology

Positions:1996-1998 Head Laboratory of Molecular Diagnostics

Institute of Pathology, Bielefeldsince 1999 Research Group Leader and Head of the

Laboratory of Molecular Diagnostics,Institute of Pathology, Hannover Medical School

Major research interests:Epigenetics of malignant neoplasiaTumor evolutionMolecular diagnosis of neoplasiaMain focus on breast cancer and hematological neoplasia in humans

Selected Publications:Lehmann U, Kreipe H. Methods 2001; 25: 409-418.Lehmann U, Celikkaya G, Hasemeier B, Länger F, Kreipe H. Cancer Res 2002;62: 6634-6638.Kleeberger W, Versmold A, Rothamel T, Glockner S, Bredt M, et al. Am J Pathol. 2003; 162(5):1487-94Tessema M, Langer F, Dingemann J, Ganser A, Kreipe H, Lehmann U.Leukemia. 2003; 17(5):910-8. Lehmann U, Brakensiek K, Kreipe H. Ann Hematol. 2003 [Epub ahead print]

First name:Ulrich

Last name:Lehmann

Acad. Title:PD Dr. rer. nat.



Further information:www.mh-hannover.de/ institute/pathologie/

Department and functionGroup Leader, Cell Biology

Education:1982-1987 Biology, Technical University of Munich1988-1992 PhD Thesis, MPI for Biochemistry, Martinsried

Positions:1992-1997 Postdoc at Washington University, St. Louis, MO, USA1997-2000 Assistant in the Department of Immunobiology,

University of Bonnsince 2000 Assistant in the Department of Cell Biology

Major research interests:Antigen processing and presentation; intracellular sorting of MHC II molecules, antigens and cofactors for antigen processing; lipid rafts and their function in MHC II biology; roles of intestinal epithelial cells in mucosal immunity

Selected Publications:Lindner R., Unanue E. EMBO J. 1996; 15: 6910-6920.Lindner R. Electrophoresis 2001; 22: 386-393.Lindner R. Traffic 2002; 3: 133-146.

First name:

Robert

Last name:Lindner

Acad. Title:Dr. rer. nat.


Phone and e-mail:++49- 511- 532-2918

[email protected]

Further information:www.mh-hannover.de/Institute/Zellbiologie/

Department and function:Group Leader, Gastroenterology, Hepatology and Endocrinologyand Molecular Biology

Education:6/96 MD1/98-12/00 Post Doc Fred Hutchinson Cancer Center, Seattle WA;

USA

Positions:since 1/96 Dept. of Gastroenterology, MHHsince 2/01 Dept.of Gastroenterology and Institute for Molecular

Biology

Major research interests:My scientific interest concentrates on the understanding of the mammalian cell cycle, specifically on the control of cyclin dependent kinases. Our research tries to elucidate the molecular regulation of cyclin kinase inhibitors by proteolytic mechanisnms. We are using biochemistry and mouse models as our main tools.

Selected Publication:Malek NP, Sundberg H, McGrew S, Nakayama K, Kyriakides TR, Roberts J. Nature2001; 413: 323-27.Zender L, Hutker S, Liedtke C, Tillmann HL, Zender S, et al. Proc Natl Acad Sci USA 2003; 100(13):7797-802.

First name:Nisar Peter

Last name:Malek

Acad. Title:Dr.med.



Further information:http://www.mh-hannover.de/ kliniken/gastro/gastro.htm

Department and function:Head, Biotechnology; FAL

Education:1973-1978 Veterinary Sciences, Veterinary University Hannover1978-1980 PhD thesis1985/86 Texas A&M University, College of Veterinary

Medicine1989: Habilitation Veterinary University Hannover1994: Apl. Professor for Reproductive Biology Veterinary

University Hannover

Positions:1980-1987: Scientist at the Institute for Animal Science1987-now: Head of Dept. Biotechnology at the Institute

Major research interests:Molecular regulation of preimplantation developmentTransgenesis in domestic species, Use of agricultural animals for biomedical applications, Aspects of somatic cloningGenetic diversity

Selected Publications:Niemann H, Wrenzycki C. Theriogenology 2000, 53: 21-34.Fernandez B, Buehler A, Wolfram S, Espanion G, Franz WM, et al. Circulation Research 2000, 87: 207-213.Kirchhof N, Carnwath JW, Lemme E, Anastassiadis K, Schöler H, Niemann H. Biol. Reprod.2000, 63: 1708-1715.Niemann H, Verhoeyen E, Wonigeit K, Lorenz R, Hecker J, et al. Transplantation 2001. 72: 1896-1906.Brambrink, Wabnitz P, Halter R, Klocke R., Carnwath J, et al. Biotechniques 2002, 33: 376-385.Kues WA, Carnwath JW, Paul D, Niemann H. Cloning Stem Cells. 2002; 4:231-43. Wrenzycki C, Herrmann D, Niemann H. Biol Reprod. 2003; 68(6):2073-80. Anger M, Kues WA, Klima J, Mielenz M, Kubelka M, et al. Mol Reprod Dev. 2003; 65(3):245-53. Terletski V, Schwarz S, Carnwath J, Niemann H. Microbiol Res. 2003; 158(2):135-42.

First name:Heiner

Last name:Niemann

Acad. Title:Prof. Dr. med.vet. Dr.habil.

Address:Dept. BiotechnologyInstitute for Animal Science, MarienseeFAL, Hoeltystr. 1031535 Neustadt

Phone and e-mail:++49-(0)[email protected]

Further information:www.tzv.fal.de

Department and function:Professor, Cardiology and Angiology

Education:1984-1990 Medical School, Albert Ludwigs

University Freiburg i. Br.1987-1990 Doctoral thesis: Role of the Renin-

Angiotensin System in Experimental Heart Failure.1992-1993 Clinical Residency, Dept. of Cardiology,

Freiburg, University Hospital1993-1996 Postdoc, Dept. Of Experimental

Pathology, EMORY University Atlanta, USA.1996- Dept. Of Cardiology and Angiology, MHH

Positions:1992-1993 Clincial Residency1993-1996 Post-doc1996-1999 Clinical Residency1999-2001 Research Associatesince 2001 Assistant Prof. of Medicine

Major research interests:Vascular biology and Signal transduction of G-Protein coupled receptors. Experimental and clinical atherosclerosis research

Selected Publications:Schieffer B., Luchtefeld M., Hilfiker A., Drexler H. Circ Res. 2000, 87:1195-1201.Krämer C, Sunkomat J, Luchtefeld M., Walden M., Forssmann WG., et al. Circ Res. 2002; 90(7):770-6.Grote K, Flach I, Luchtefeld M, Akin E, Holland SM, et al. Circ Res. 2003; 92(11): e80-6 Luchtefeld M, Drexler H, Schieffer B. Biochem Biophys Res Commun. 2003; 308(3):668-72.

First name:Bernhard

Last name:Schieffer

Acad. Title:PD Dr. med.


Phone and e-mail:++49-511-532 4666++49-511-532 [email protected]

Further information:www.mh-hannover.de/ kliniken/kardiologie/htm/ home.html

Department and function:Director, Cell and Molecular Pathology

Education:1975-1982 Studied medicine at the Ludwig Maximilian University

in Munich and the Christian Albrecht University of Kiel

Positions:1983-2000 Assistant, University Lecturer, then Professor at the

Institute of Human Genetics, University of Kiel1987-2000 Deputy Director of the Institute of Human Genetics,

University of Kiel2001-2003 Director of the Institute of Cell and Molecular

Pathology, Hannover Medical School

Major research interests:My main interests are tumor genetics, with particular emphasis on the dissection of tumorigenesis, development of new diagnostic tools, and on genetic counseling in hereditary cancer syndromes.

Selected Publications:Zhang Q, Siebert R, Yan M, Hinzmann B, Cui X, et al. Nature Genetics 1999; 22: 63-68Schlegelberger B, Zwingers T, Harder L, Nowotny H, Siebert R, Vesely M, et al. Blood 1999; 94: 3114-3120Zhang Y, Matthiesen P, Harder S, Siebert R, Castoldi G, et al. Genes Chromosomes Cancer 2000; 27:52-58Metzke-Heidemann S, Harder L, Gesk S, Schoch R, Jenisch S, et al. GenesChromosomes Cancer 2001; 31: 10-14 McPherson JD, Marra M, Hillier L, Rosenthal A, Wen G, et al. Nature 2001; 409: 934-41 Steinemann D, Gesk S, Zhang Y, Harder L, Pilarsky C, et al. Genes Chromosomes Cancer. 2003; 37(4):421-6Wilkens L, Flemming P, Gebel M, Bleck J, Terkamp C, et al. Proc Natl Acad Sci USA. 2004;101(5):1309-14.

First name:Brigitte

Last name:Schlegelberger

Acad. Title:Prof. Dr..



Further information:www.mh-hannover.de/institute/zellpathologie/

Department and function:Director, Clinical ImmunologyChairman of the MD/PhD Program

Education:1976 M.D., Medical School of the Rheinische Friedrich-

Wilhelms-Universität Bonn1977 Masters of Psychology, Rheinische Friedrich-Wilhelms-

Universität Bonn

Positions:1978-83 Instructor in Medicine, Medical School of the University

of Bonn1986-94 Associate Professor of Medicine and Immunology,

Hannover Medical School1995- Head, Professor of Medicine and Immunology, Dept.

Clinical Immunology, Hannover Medical School

Major research interests:Fc receptors, regulation and activation, role in pathogenesis of diseases; activation mechanisms of human natural killer cells; pathogenesis of vasculitis and chronic rheumatoid arthritis; immunotherapy (cytokines and immunoglobulins); immunodeficiencies, AIDS - pathogenesis and treatment; clinical therapy studies

Selected Publications:Hundt M, et al. Eur J Immunol 2001; 31:3475-83.Tillmann HL, et al. N Engl J Med 2001; 345: 715-24Behrens GMN, et al. J Clin Invest 2002; 110: 1319-27.Shushakova N, et al. J Clin Invest 2002; 110: 1823-30.Behrens GM, et al. Eur J Med Res. 2003;8(5):221-5.Werwitzke S, et al. Clin Exp Immunol. 2003;133(3):334-43. Drescher B, et al. Immunology. 2003;110(3):335-40Ulbricht KU, et al. Arthritis Rheum. 2003; 48(12):3542-3.

First name:Reinhold Ernst

Last name:Schmidt




Further information:www.mh-hannover.de/kliniken/immunwww-mh-hannover.de/studium/phd

Department and function:Director, Human Genetics

Education:1966-1973 Universities of Freiburg and Basel, Medicine

Positions: 1988-1990 Professor of Human Genetics, Berlin1990- Professor of Human Genetics, Director and Chair, MHH

Major research interests:Molecular Basis of Inherited Disease, Genetics of Behavior in Subhuman Primates, Structure and Ethics of Genetic Service Provision

Selected Publications:Krawczak and Schmidtke: DNA-Fingerprinting, Bios, Oxford (1998)Trefilov, Berard, Krawczak and Schmidtke, Behavior Genet. 2000; 30: 295.Rommel, Karck, Haverich, Schmidtke, Arslan-Kirchner, Hum. Mutat 2002; 20: 406Schmidtke, Nippert, Wolff, Int. Encycl. Soc. Behav. Sci, 6092 (2001)Schubert S, Skawran B, Dechend F, Nayernia K, Meinhardt A, et al. Biol Reprod. 2003; 69(3):968-75.

First name:Jörg

Last name:Schmidtke


Address: OE 6300Hannover Medical School


Further information:www.human-genetik.net

Department and function:Director, Virology

Education:1980 MD Mainz1986 Habilitation Innsbruck

Positions:1996 MRCPath, London, 2003 FRCPath, London,

Major research interests:Kaposi‘s sarcoma – associated herpesvirus/human herpesvirus 8

Selected Publications:Glenn M, Rainbow L, Aurade F, Davsion A, Schulz TF. J.Virol. 1999; 73: 6953 –6963;Platt GM, Simpson GR, Mittnacht S, Schulz TF. J. Virol. 1999; 73: 9789 – 9795.Greensill J, Sheldon J, Renwick NM, Beer B, Norley S, et al. J. Virol. 2000; 74:1572-1577.Luppi M, Barozzi P, Schulz TF, et al. N Engl J Med 2000; 343: 1378-1385Viejo-Borbolla A, Kati E, Sheldon J, Nathan K, Mattsson K, et al. J.Virol. 2003; 77(12):7093-100.Brinkmann MM, Glenn M, Rainbow L, Kieser A, Henke-Gendo C, Schulz TF. J Virol. 2003; 77(17):9346-58.

First name:Thomas F.

Last name:Schulz

Acad. Title:Prof. Dr. med., FRCPath



Department and function:Group Leader, Transplant Laboratory

Education:1983 Degree of „Diplom-Biologe“ (Masters Degree in

Biology), University of Braunschweig

1987 Degree of „Dr.rer.nat.“ (PhD), University of Hannover

1994 Habilitation; Venia legendi for Immunology, Hannover Medical School (MHH)

Positions:1983-1987 Research Assistant, MHH

1987-1990 Research Associate, MHH

1990-1991 Fellowship of the German Research Council (DFG), National Jewish Center for Immunology, Denver

1991- Group leader, Transplant Laboratory, MHH

1999- Professor of Immunology

Major research interests:Transplant Immunology/Xenotransplantation: Analysis of human anti-pig T cell responses, development of immunomodulatory antibodies, immunological monitoring of transplant recipients.Analysis of T cell activation in the human: Signal transduction, role ofcell surface molecules (CD28, CD45), CD45 polymorphisms.

Selected Publications:Siefken R, Klein-Heßling S, Serfling E, Kurrle R, Schwinzer R. J Immunol 1998; 161:1645-1651 Jacobsen M, Schweer D, Ziegler A, et al. Nature Gen 2000; 26:495-499Niemann H, Verhoeyen E, Wonigeit K et al. Transplantation 2001; 72:1898-906 Dulat H, von Grumbkow C, Baars W, Schröder N, Wonigeit K, Schwinzer R. Eur J Immunol 2001; 31: 2217-2226Schwinzer R, Witte T, Hundrieser J, et al. Genes Immun 2003; 4:168-169

First name:Reinhard

Last name:Schwinzer

Acad. Title:Prof. Dr.rer.nat.



Further information:www.mh-hannover.de/kliniken/visceralchirurgie/

Department and function:Assistant Professor, Virology

Education:1982 – 1988 University of Bonn, Biology1988 – 1989 Columbia University, New York, NY, USA

Immunology1989 - 1993 European Molecular Biology Laboratory, Heidelberg,

Cell Biology

Positions:1993 - 1997 Postdoc and Staff Scientist, Yale University,

New Haven, CT, USA, Dept. Cell Biology1997 – 2002 Group leader, Biochemistry Dept., MHH

Major research interests:Our group is interested in the cell biology of complex DNA viruses. How does a virus get access to a cell, disassemble to uncover its genome for replication, and how is – within a couple of hours – the viral program switched to virus assembly and egress? We have developed several in vivo and in vitro motility assays to analyse the cell biology of Herpes Simplex Virus and particularly the microtubule-mediated capsid transport by digital video microscopy. Using these assays, we characterize cytosolic host factors as well as structural viral proteins important in HSV1 entry and egress.

Selected Publications:Sodeik, Doms, Ericsson, Hiller, Machamer, van' t Hof, et al. J of Cell Biology 1993;121:521-541.Sodeik, Ebersold, Helenius. J of Cell Biology 1997; 136:1007-1021.Ojala, Sodeik, Ebersold, Kutay, Helenius. Mol & Cell Biology 2000; 20:4922-4931.Döhner, Wolfstein, Prank, Echeverri, Dujardin, Vallee, & Sodeik. Molecular Biology Cell 2002; 13:2795-2809.Mabit H, Nakano MY, Prank U, Saam B, Dohner K, et al. J Virol. 2002; 76(19):9962-71

First name:Beate

Last name:Sodeik

Acad. Title:HD Dr. rer.nat.



Further information:www.mh-hannover.de/institute/virologie/

Department and function:Group Leader, Pediatric Nephrology and Metabolic Diseases,Consultant for Transplant and Nephrology Ward, Dialysis and Outpatient Service

Education:1975-1983 Medical Schools at Bochum, Stanford and Hamburg1983-85 Clinical Anesthesia

Positions:1985-1986 Pediatrics and Transplant Medicine Heidelberg 1986-1993 Pediatrics, Intensive Care and Pediatric Nephrology,

UKE Hamburg1993-1996 Research Fellow and Deputy Chief of Lab. Div. Of

Immunology, TB Strom Beth Israel Deaconess MedicalCenter, Harvard Medical School, Boston

1996-1997 Clinical Consultant Pediatric Nephrology Charite Berlin1998-now MHH

Major research interests:Transplant Immunology, Activation and Silencing of T-Cells, Quantitative Measurement of T-Cell ResponsesT-Cell Effectors, T-cell driven Primary Renal Diseases

Selected Publications:Strehlau J, Pavlakis M, et al. Proc Natl Acad Sci U S A. 1997;94(2):695-700. Strehlau J, Schachter AD, et. Al. Kidney Int. 2002;61(1):90-5.Pape L, Froede K, Strehlau J, Ehrich JH, Offner G. Pediatr Transplant. 2003; 7(4):302-4Melk A, Henne T, Kollmar T, Strehlau J, Latta K, et al. Kidney Int. 2003; 64(1):314-20.

First name:Juergen

Last name:Strehlau



Phone and e-mail:0511-532-5597/[email protected]

Department and function:Professor, Human Genetics

Education:1980 – 1986 Free University Berlin, Medicine1988 MD1995 Specialist in Human Genetics2002 apl. Professorship

Positions:1987 Guestdoc, Cerrahpasha Medical Faculty,

Istanbul, Turky1988 – 1990 Postdoc, Inst. Humangenetics, FU BerlinSince 1991 Head of Molecular Diagnostics, Inst. Human

Genetics, Medical School Hannover

Major research interests:Molecular genetics of several monogenenic disorders like cysticfibrosis, haemochromatosis, morbus Osler, ataxia telangiectasia; neuro-and psychiatro-genetics, genetic screening

Selected Publications:M.Stuhrmann,T.Dörk. Andrologia 2000; 32; 71-83O.Schöffski, J.Schmidtke, M.Stuhrmann. Community Genetics 2000; 3:2-11M.Stuhrmann, N.Graf, T.Dörk, J.Schmidtke. Journal of Pediatrics (Suppl III) 2000;159:S186-S191M.Stuhrmann, L.Bashawri, MA.Ahmed, et al. British Journal of Haematology2001, 112: 616-620J.Ockenga, T.Dörk, M.Stuhrmann. Journal of Medical Genetics 2001; 38:243-244D.Heller, U.Schneider, J.Seifert, KF.Cimander, M.Stuhrmann. Addiction Biology2001, 6:183-187M.Schürmann, M.Albrecht, E.Schwinger, M.Stuhrmann. Eur J Hum Genet 2002;10:729-732Groman JD, Hefferon TW, Casals T, Bassas L, Estivill X, et al. Am J Hum Genet. 2004; 74(1):176-9.

First name:Manfred

Last name:Stuhrmann-Spangenberg




Further information:www.mh-hannover.de/kliniken/humangenetik

Department and function:Professor; Gastroenterology, Hepatology and Endocrinology

Education:1979 Abitur, Max-Planck-Gymnasium,

Nürtingen/Baden-Württemberg1979-81 Apprenticeship, Dresdner Bank AG, Stuttgart1981-87 Study of Medicine, University of Mainz and

Tübingen1987 M.D., University o Mainz 1988 FMGMES

Positions:1988-91 Internal Medicine, University of Mainz1991-93 Dep. of Pharmacology, UCSD, USA1993-96 Dep. of Gastroenterology & Hepatology1996- Associate Professor Dep. of Gastroenterology,

Hepatology & Endocrinology

Major research interests:Mechanisms of viral and immune mediated liver failure and liver regeneration in humans and animal models

Selected Publications:Ludde T, Kubicka S, Plumpe J, Liedtke C, Manns MP, et al. Oncogene. 2001; 20: 5264-78.Jaeckel E, Cornberg M, Wedemeyer H, Santantonio T, Mayer J, et al.. N Engl J Med. 2001; 345: 1452-7.Bock CT, Tillmann HL, Torresi J, Klempnauer J, Locarnini S, et al. Gastroenterology. 2002; 122: 264-73.Wuestefeld T, Klein C, Streetz KL, Betz U, Lauber J, et al. J Biol Chem. 2003; 278: 11281-8. Tacke F, Brabant G, Kruck E, Horn R, Schoffski P, et al. J Hepatol. 2003; 38(4):447-54Luedde T, Rodriguez ME, Tacke F, Xiong Y, Brenner DA, Trautwein C.Hepatology. 2003; 37(4):833-41.Liedtke C, Groger N, Manns MP, Trautwein C. J Biol Chem. 2003; 278(30):27593-604.Bock CT, Buerke B, Tillmann HL, Tacke F, Kliem V,et al. Gastroenterology. 2003; 124(7):1809-20. Klein C, Wustefeld T, Heinrich PC, Streetz KL, Manns MP, Trautwein C.Eur J Immunol. 2003; 33(8):2251-61

First name:Christian

Last name:Trautwein



Phone and e-mail:xx49/511/[email protected]

Further information:http://www.mh-hannover.de/kliniken/gastro/gastro.htm

Department and function:Head, ‘Clinical Reasearch Group Pseudomonas‘

Education and positions:1971 - 1976 study of biochemistry1974 - 1981 study of medicine1979 Dr. rer.nat.1984 Dr. med.1991 habilitation1992 professorship

Major research interests:• Genomics• Molecular pathology of cystic fibrosis• Pseudomonas genomics

Selected Publications:Bronsveld I, Mekus F, Bijman J, Ballmann M, de Jonge HR, et al. J Clin Invest. 2001;108:1705-15.Wiehlmann L, Salunkhe P, Larbig K, Ritzka M, Tümmler B. Genome Letters 2002, 1: 123-130Larbig KD, Christmann A, Johann A, Klockgether J, et al. J Bacteriol. 2002; 184:6665-80.Weinel C, Nelson KE, Tümmler B. Environmental Microbiology 2002, 4: 809-818Kiewitz C, Tümmler B. Genome Letters 2002, 1: 111-114 Mekus F, Laabs U, Veeze H, Tümmler B. Hum Genet. 2003;112:1-11.

Klockgether J, Reva O, Larbig K, Tummler B. J Bacteriol. 2004; 186(2):518-34.

First name:Burkhard

Last name:Tümmler

Acad. Title:Prof. Dr. Dr.



Further information:http://www. mh-hannover.de/ kliniken/kinderheilkunde/kfg/index.htm

Department and function: Director, Cell Biology

Education:1974: Diploma in Biology from the Free University Berlin1976: PhD obtained from the Free University Berlin1977-79: EMBO Fellow at the MRC Unit for Biophysics at

King‘s College in London, UK1979-82: Postdoctoral fellow (DFG) at the Biological

Laboratories at Harvard University (Cambridge, Ma)1982-84: Heisenberg-Fellow at the LMB in Cambridge (UK)

and the Max-Planck Institute for BiophysicalChemistry in Göttingen, Germany.

Positions:1986-92: Junior-Research group leader at the Max-Planck-

Institute for Biochemistry, Martinsried, Germany1992-1998: Associate Professor at the Dept. of pathology at

Washington University St. Louis, MOsince 1998: Professor for Cell Biology at MHH

Major research interests:Intracellular vesicular transport, functions of molecular chaperones

Selected Publications:Ungewickell, E., H. Ungewickell, et al. Nature 1995; 378: 632-635.Umeda, A., A. Meyerholz, et al. Eur J Cell Biol 2000; 79(5): 336-342.Scheele, U., C. Kalthoff, et al. J Biol Chem 2001; 276(39): 36131-36138.Kalthoff, C., S. Groos, et al. Mol Biol Cell 2002; 13(11): 4060-4073.Kalthoff, C., J. Alves, et al. J Biol Chem 2002; 277(10): 8209-8216.Scheele, U., J. Alves, et al. J Biol Chem. 2003; 278(28):25357-68.Hinrichsen, L., J. Harborth, et al. J Biol Chem. 2003; 278(46): 45160-70.

First name:Ernst

Last name:Ungewickell

Acad. Title:Prof. Dr. rer. nat.


Phone and e-mail: ++49-511- 532 [email protected]

Further information:www.mh-hannover.de/institute/zellbiologie/

Department and function:Head, Central Institute for Biophysical and BiochemicalProcedures

Education:1968-1972 Chemistry, Technical University Braunschweig1972 – 1976 Dissertation, University Hannover

Positions:1973- Hannover Medical School

Major research interests:Protein nucleic acid and protein protein interactions Single stranded DNA binding proteins, analytical ultracentrifugation, biophysical chemistry in solution

Selected Publications:Urbanke C, Wray J. Biochem J 2001; 358:165-73 Grazulis S, Deibert M, Rimseliene R, Skirgaila R, Sasnauskas G, et al. Nucleic Acids Res 2002; 30(4):876-85Meyer S, Urbanke C, Wahle E.. Biochemistry 2002 ;41(19):6082-9Landwehr M, Curth U, Urbanke C. Biol Chem 2002; 383(9):1325-33 Schubert WD, Urbanke C, Ziehm T, Beier V, Machner MP,et al. Cell 2002; 111(6):825-36Witte G, Urbanke C, Curth U. Nucleic Acids Res. 2003; 31(15):4434-40Zaremba M, Urbanke C, Halford SE, Siksnys V J Mol Biol. 2004; 336(1):81-92

First name:Claus

Last name:Urbanke




Further information:http://www.mh-hannover.de/einrichtungen/bpc/

Department and function: Head, Molecular Immunology, GBF

Education:1969-1978 Biology at the Free University of Berlin,

Special Studies: Molecular Biology and Genetics1974-1978 PhD Student at the Basel Institute for Immunology,

Basel, Switzerland

Positions:1978-1980 Research Associate at the Salk Institute for Biological

Studies, Department of Developmental Biology, San Diego,USA.

1980-1983: Scientific Assistant at the Friedrich-Miescher-Laboratorium of the Max-Planck-Gesellschaft, Tübingen, Germany.

1983-1989: Member at the Basel Institute for Immunology, Basel, Switzerland.

1989-1990: Visiting Professor at the Institute for Immunology and Rheumatology, University of Oslo, Oslo, Norway.

1990-present: Group leader at the GBF (Gesellschaft für Biotechnologische Forschung), Braunschweig, Germany.

Major research interests:Interaction of bacteria with the immune system.B cell development.

Selected PublicationsDarji A, Guzmán CA, Gerstel B, Wachholz P, Timmis KN, Wehland J, ChakrabortyT, Weiss S. Cell 1997; 91: 765-775.Engel H, Bogen B, Müller U, Andersson J, Rolink A, Weiss S. Eur. J. Immunol. 1998; 28: 2289-2299.Hense M, Domann E, S. Krusch S, Wachholz P, Dittmar KEJ, Rohde M, Wehland J, Chakraborty T, Weiss S. Cell. Microbiol. 2001; 3: 599-609 .Krusch S, E. Domann E, M. Frings M, A. Zelmer A, M. Diener M, T. Chakraborty T, S. Weiss S. J. Gene Med. 2002; 4, 655-667.Kretschmer K, Joungebloud A, Stopkowicz J, Stoermann B, Hoffmann R, Weiss S.J. Immunol. 2003; 171, 1192-201.

First name:Siegfried

Last name:Weiss

Acad. Title:Dr. rer.nat.

Address:AG MolekulareImmunologie,Mascheroder Weg 1a,38124 Braunschweig

Phone and e-mail:++49-0531-6181-230, [email protected]

Further information:[email protected]>-> Forschung Molecular Immunology

Department and function:Director, Pediatric Hematology/Oncology

Education:1969-1973 University Tübingen, Medicine1973-1975 Freie Universität Berlin1975 Dr. med.1976 Approbation1984 Board certified Pediatrician

Positions:1985-1987 Assist. Professor, Head Laboratory of

Cytokine Biology, Memorial Sloan KetteringCenter, New York

1987-1993 Professor for Pediatrics, MHH1993-1997 Professor for Specific Pediatric Hematology

and Oncology, MHHSince 1997 Head, Dept. of Pediatric Hematology/

Oncology, MHH

Major research interests:Cytokines, Hematopoietic stem cells, Bone marrow failure syndromes, Leukemias

Selected Publications:Welte K, Gabrilove J et al. Blood 1996 88 (6): 1907-1929.Ballmaier M, Germeshausen M et al. Blood 2001; 97 (1) 139-146.Tschan CA, Pilz C, Zeidler C, Welte K et al. Blood 2001; 97(6):1882-1884.Germeshausen M, Ballmaier M,Welte K. Ann NY Acad Sci 2001; 938:305-320.Germeshausen M, Schulze M, Ballmaier et al. Br J Hematol. 2001; 115:222-224.Zeidler C, Welte K. Semin Hematol 2002; 39(2):82-88.Dale DC, Cottle TE, Fier CJ, Bolyard AA et al. Am J Hematol. 2003; 72(2):82-93.Beger C, Gerdes K, Lauten M, Tissing WJ, Fernandez-Munoz I, et al. Br J Haematol. 2003;122(2):245-52.

First name:Karl

Last name:Welte


Address:OE 6780Hannover MedicalSchool


Further information:www.mh-hannover.de/Kliniken

Department and function:Professor, Dermatology

Education:Medical Doctor, Professor of Medicine

Positions:1985-1989 Post Doc in the Dept´s of Immunology in Hannover and in Goettingen1989-1994 Clinicail Education in the the Field of Dermatology in Hannoversince 1994: Registrar („Oberarzt“) in the Dept of Dermatology

Major research interests:Dermatoimmunology:Specifity and functions of skin infiltrating T-cells in eczemaRegulation of cytokine pattern in human T-cells and antigen-presenting cellsExpression and function of anaphylatoxin receptors

Selected Publications:Werfel T, Kirchhoff K, Wittmann M, Begemann G, Kapp A, Heidenreich F, Götze O, Zwirner J. J Immunol 2000; 165:6599-6605Schmid-Ott G, Jaeger B, Meyer S, Stephan E, Kapp A, Werfel T. J Allergy Clin Immunol 2001; 108:455-462Gutzmer R, Langer K, Lisewski MS, Mommert S, Kapp A, Werfel T. J Allergy Clin Immunol 2002; 109:524-531Wittmann M, Kienlin P, Mommert S, Kapp A, Werfel T. J Immunol 2002; 168:3793-3800Gutzmer R, Langer K, Mommert S, Wittmann M, Kapp A, Werfel T. J Immunol. 2003; 171(12):6363-71. Weinmann O, Gutzmer R, Zwirner J, Wittmann M, Langer K, et al. Immunology 2003; 110(4):458-65.

First name:Werfel

Last name:Thomas

Acad. Title:Prof Dr. med.

Address:Dept DermatologyHannover Medical SchoolRicklinger Str. 530449 Hannover

Phone and e-mail:[email protected] [email protected]

Further information:http://www.klinikum-hannover.de/hkl/

Department and function:Juniorprofessor, Dermatology

Education:1989 Abitur, Gymnasium am Geroweiher,

Mönchengladbach1989-96 University Studies, Human Medicine, Heinrich-Heine

University, Düsseldorf

Positions:1996 – 2003 Residency, Department of Dermatology, Hannover

Medical School1999-2001 Postdoctoral Research (DFG Grant)12/2002 - Juniorprofessorin, Department of Dermatology,


Major research interests:Inflammation in eczematous skin diseases, regulation of IL-12, Th1 / Th2 „specific“ transcription factors, heat shock proteins in inflammatory skin diseases (HSP70, HSP27, gp96)

Selected Publications:Wittmann et al. Blood 1999; 94:1717Wittmann et al. Int Arch Allergy Immunol 2001; 124:346Wittmann et al. J Immunol 2002; 168:3793Gutzmer R, Langer K, Mommert S, Wittmann M, Kapp A, Werfel T. J Immunol. 2003; 171(12):6363-71.

First name:Miriam

Last name:Wittmann


Address:Ricklinger Str. 530449 Hannover

Phone and e-mail:0511 9246 278miriamwittmann@ web.de

Further information:http://www.klinikum-hannover.de/hkl/

Department and function:Head, "In Vitro Differentiation" Group, IPK Gatersleben

Education:1964-1969 Study of biology at the Univ. of Greifswald1970-1974 PhD thesis at the Institute of Genetics Gatersleben /

University of Halle1997 Habilitation and venia legendi ("Cell Biology") at the

Medical Faculty, University of Halle

Positions:1974-1991 Scientific co-worker (Mutagenesis and embryonic

stem cell research) Institute of Genetics, Gatersleben,

Academy of SciencesSince 1992 Head of the Research Group "In Vitro Differentiation",

IPK Gatersleben

Major research interests:-Stem cell research: Embryonic and adult (intestinal, hematopoietic) stem cells-Stem cell differentiation into cardiac, skeletal, vascular smooth muscle, neuronal and pancreatic cells-Analysis of cell-cell and cell-matrix interactions-Embryotoxicity analysis in vitro using embryonic stem cells

Selected Publications:Rolletschek A, Chang H, Guan K, Czyz J, Meyer M, Wobus AM. Mech. Dev.2001; 105:93-104.Boheler KR, Czyz J, Tweedie D, Yang H-T, Anisimov SV, Wobus AM. Circ.Res. 2002; 91:189-201.Blyszczuk P, Czyz J, Kania G, Wagner M, Roll U, St-Onge L, Wobus AM.Proc. Natl. Acad. Sci. USA 2003; 100:998-1003Czyz J, Nikolova T, Schuderer J, Kuster N, Wobus AM. Mutat Res. 2004; 557:63-74. Kania G, Blyszczuk P, Czyz J, Navarrete-Santos A, Wobus AM. Methods Enzymol. 2003;365:287-303. Czyz J, Wiese C, Rolletschek A, Blyszczuk P, Cross M, Wobus AM. Biol Chem. 2003; 384(10-11):1391-409.

First name:Anna M.

Last name:Wobus

Acad. Title:PD Dr. rer. nat.

Address:Institute of Plant Genetics (IPK Gatersleben)Corrensstr. 306466 Gatersleben


Further information:www.ipk-gatersleben.de

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MD/PhD Program “Molecular Medicine“ - MH … · approach, including ... The MD/PhD Program “Molecular Medicine“ started in winter semester 2000/01. Since 01.01.2002 ... “non