ACCELERATING YOUR BIOBASED TECHNOLOGY FROM IDEA TO COMMERCIAL REALITY

• Derisking • Process Development • Scale-Up • • Application Testing & Product Development •

Are you ready for MBI? Contact a member of our Business Team, today.

Chad Pastor Jim Wynn Allen Julian pastor@mbi.org wynn@mbi.org julian@mbi.org (o) 517.336.4647 (o) 517.336.4620 (o) 517.336.4613 (m) 517.525.1941 (m) 517.755.6933 (m) 517.290.8769

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cover photo: iStock Images © 2014 interior photos: Trumpie Photography © 2009

What You Can Expectat Our Facilities

Bench-Scale: Bioprocess Development, Optimization, & DeriskingMBI’s team collaborates with you, accelerating your technology to commercial readiness. Our highly experienced team has a long history of developing robust, scalable bioprocesses and fermentations. In the last five years alone, we have successfully scaled over 20 different technologies from the lab to pilot-scale—with a 100% success rate.

Bioprocessing Development & FermentationOur expert team is an invaluable resource in suc-cessfully scaling your technology, including:

•• strain improvement & media optimization •• bacteria/yeast/fungi/heterotrophic algae •• process development & control •• aerobic/anaerobic/microaerobic •• sterile/non-sterile •• batch/fed batch/continuous fermentations

Pilot Plant Scale-UpMBI’s pilot plant serves as your very own bioprocessing and scale-up facility, replacing the need for you to build your own. What’s more, we are committed to collaboration, helping to map out the best plan for your innovation’s scale-up:

•• biomass processing •• fermentation •• separation •• purification & recovery

Our three-level pilot facility is equipped with modern equipment, instrumentation, and computer-based control systems. Our facility is plug-and-play: a five-ton capacity ceiling crane can bring in equipment necessary to accelerating your technology.

Also on-site, MBI has two 3,800L fermentors, along with 150L and 200L units–as well as four 10L “satellite” units—used to diagnose scale-up effects. All process development and pilot plant fermentors have in-line mass spectrometer off-gas analysis and a complete suite of automated process control.

Application Testing & Product DevelopmentUsing our 3,800L pilot plant, MBI’s team has the ability to manufacture your product in volumes needed to support pre-commercial process and product development, application testing, and routine pilot-scale production. Our clients sometimes require multiple batches for quality assurance and product validation purposes. In addition to prodividing these services, we are often an invaluable resource for companies seeking venture capital funding and requiring third-party validation of their process technology and product performance.

Scale-Up Beyond MBI: Tech TransferWith a 100% technology transfer success rate, you can count on us to successfully transfer your process directly to either your manufacturing team or production partner.

Some of our successful collaborations include: Bolt Threads, DuPont, Genomatica, Verdezyne, OPX BIO, Amyris, Novozymes, Marrone Bio Innovations, Metabolix, and Tepha Medical Devices.

Let us help drive your bioprocess development or scale-up project to commercial reality—join our growing list of successful collaborations.

Equipment OverviewBioprocess Development Lab

•• 22 computer-controlled fermentor units, with 30 vessels •• 6 x 10 L •• 16 x 5 L •• 4 x 2 L •• 4 x 1 L

Pilot Plant

•• 2 x 3800 L •• 1 x 200 L •• 1 x 150 L •• 1 x 80 L

Analytical facilities

•• Multiple HPLC, UPLC, GC, GC/MS •• UV-Vis Spectroscopy •• YSI glucose analysis •• Protein analysis •• Full access to MSU analytical equipment, including HPLC/MS/MS and NMR

What You Can ExpectFrom Our Team

Downstream Processing Capabilities

•• High-speed disc stack centrifugation •• Solid-Liquid, Liquid-Liquid separation •• Filtration, ultrafiltration, microfiltration •• Chromatographic processes •• Electrodialysis •• Ion Exchange •• Cell Disruption •• Vacuum Evaporation •• Solvent Extraction [at bench or MSU BI] •• Crystallization & tray drying •• Homogenization •• Additional space and full utilities set-up for client or rental DSP equipment

At MBI, we offer collaborative, custom-tailored solutions to advance your technology to commercial readiness. Our team’s disciplined derisking process vets your biobased technology, quickly weeding out flawed approaches—saving you both time and money. The end result: the acceleration of your technology to commercialization. Our mission serves you. As a non-profit biotechnology accelerator, we help you and your team drive your sustainable, biobased innovation to commercial reality.