Mayo Clinic School of Continuous Professional Development 13400 East Shea Boulevard Scottsdale, Arizona 85259 Telephone: (480) 301-4580

Dear Representative, On behalf of Mayo Clinic and Mayo Clinic School of Continuous Professional Development, we are pleased to announce our new continuing medical education activity Mayo Clinic’s “Updates in Cardio-Oncology: Challenges and New Frontiers” that will be held February 1-3, 2018 at the Omni Scottsdale Resort at Montelucia in Scottsdale, Arizona. We invite you and your company to exhibit at this CME activity. The exhibit fee is $3,000. Space is limited; early registration is advised. This course reviews clinically important information regarding the management of cardiac and vascular diseases affecting patients with cancer and cancer survivors. The interactive, practice-based format includes case presentations and state-of-the-art lectures in recent and topical developments in this emerging field. The goal is to improve quality, safety and outcomes for patients within the dynamic and interactive educational experience. The current state of knowledge of common cardiovascular complications such as heart failure (HF), myocardial ischemia, hypertension (HTN), thromboembolism, QT prolongation, and bradycardia is associated with frequently used anticancer medications. As you can see from the attached program, we have designed an excellent course to give clinical cardiologists, heart failure specialists, oncologists, hematologists, internal medicine specialists, and allied health personnel working in cardiology or hematology-oncology areas clinically important information in cardio-oncology. NEW – Mayo Clinic now offers a variety of sponsorship opportunities for industry support! Please refer to the attached sponsorship description page for available opportunities. If you will join us, please complete the attached exhibitor agreement and return it with your payment (made payable to Mayo Clinic in Arizona) to Mayo Clinic School of Continuous Professional Development, Attn: Kristy Badder, 13400 East Shea Boulevard, Scottsdale, AZ 85259. Please denote course activity #18S05119 on all correspondence. Mayo Clinic’s Tax ID number is 86-0800150; our W-9 form is attached for your convenience. To maintain a clear separation of promotion from education, exhibits will be located adjacent to where the educational sessions will be held. Displays should be staffed during breakfasts, breaks, and lunches February 1-3, times are denoted on the attached program. We hope you will join us in Scottsdale in February! Sincerely,

Farouk Mookadam, M.B., B.Ch. Course Director Consultant, Cardiovascular Diseases Professor of Medicine Mayo Clinic College of Medicine

Donald W. Northfelt, M.D. Course Director Consultant, Medical Oncology Professor of Medicine Mayo Clinic College of Medicine

Mayo Clinic School of Continuous Professional Development (MCSCPD) Sponsorship Opportunities

Opportunity Cost Lanyards $2,000 (Sponsor-provided, pre-printed lanyards; limited to one organization) Every attendee is required to wear a name badge, so what better way to advertise your company than with your logo on a lanyard! (Quantity to be determined 60 days before course.)

Drawstring Bags $3,000 (Sponsor-provided, pre-printed drawstring bags; limited to one organization) Help keep course attendees organized by providing them with a drawstring bag to carry their course materials in with your company’s logo on it! Drawstring bags to be provided by sponsor; artwork and bag are subject to MCSCPD approval. (Quantity to be determined 60 days before course.)

Hotel Key Cards $4,000 (Limited to one organization) Personalize hotel guest room keys with your company’s logo or product promotion for immediate exposure to attendees. Use this as a great way to introduce yourselves to our attendees upon checking into the host hotel. Artwork to be provided by sponsoring company and is subject to MCSCPD approval. (Artwork is due to MCSCPD 90 days before course.) Conference Bag Inserts $1,500 each (Multiple opportunities available) Conference bag inserts are a great opportunity to invite attendees to your booth, announce your booth participation or conference- related event. Your company will provide copies of the flyer or advertisement (no larger than 8 ½ x 11, no more than one page) and the MCSCPD will stuff them into the official conference bags. A limited number of bag inserts are permitted, so early reservation is encouraged. Artwork is subject to MCSCPD approval. (Quantity of fliers/advertisements to be determined 60 days before course.)

As an industry supporter, if you have a sponsorship opportunity idea that isn’t mentioned on this page, please contact MCSCPD to discuss.

If you are interested in one of our sponsorship opportunities contact MCSCPD for more information at mca.cme@mayo.edu or 480-301-4580.

Page 1 of 2

Mayo Clinic School of Continuous Professional Development (MCSCPD)

Exhibitor Agreement

Agreement between: ACCREDITED PROVIDER: Mayo Clinic College of Medicine and Science – MCSCPD AND:

Company Name (Exhibitor) (as it should appear on printed materials)

Exhibit Contact (if different then exhibit Rep.) Name(s) of Representative(s) Exhibiting (Maximum of two representatives allowed per exhibit)

Address Telephone Fax Email The named exhibitor wishes to exhibit at the above named activity for the amount of $3,000

Sponsorship Opportunities ☐ Lanyards (limited to one organizations) $2,000 ☐ Drawstring Bags (limited to one organization) $3,000 ☐ Hotel Key Cards (limited to one organization) $4,000 ☐ Conference Bag Inserts (multiple opportunities available) $1,500

TOTAL AMOUNT $

NOTE: There may be additional charges depending on the meeting location (power, internet access, etc.). Please list additional requests here: (please note: additional requests may incur additional fees)

TERMS AND CONDITIONS • EXHIBITOR agrees to abide by ACCME Standards for Commercial Support as stated at www.accme.org: SCS 4.2:

“Product-promotion material or product-specific advertisement of any type is prohibited in or during CME activities. The juxtaposition of editorial and advertising material on the same products or subjects must be avoided. Live (staffed exhibits, presentations) or enduring (printed or electronic advertisements) promotional activities must be kept separate from CME.” “For live, face-to-face CME, advertisements and promotional materials cannot be displayed or distributed in the educational space immediately before, during or after a CME activity. Providers cannot allow representatives of Commercial Interests to engage in sales or promotional activities while in the space or place of the CME activity.”

• EXHIBITOR may only distribute educational promotional materials at their exhibit space. Distribution of non-educational items (pens, notepads, etc.), pharmaceuticals or product samples is prohibited.

• All exhibit fees associated with this activity will be given with the full knowledge of the PROVIDER. No additional payments, goods, services or events will be provided to the course director(s), planning committee members, faculty, joint provider, or any other party involved with the activity.

Activity Title Updates in Cardio-Oncology: Challenges and New Frontiers Activity Number 18S05119 Location Omni Scottsdale Resort at Montelucia, Scottsdale, Arizona Exhibit Dates February 1-3, 2018

Page 2 of 2

• Completion of this agreement represents a commitment and payment is due and collectible by the ACTIVITY DATE unless

otherwise agreed upon by the PROVIDER. PROVIDER reserves the right to refuse exhibit space to EXHIBITOR in the event of nonpayment or Code of Conduct violation.

• PROVIDER agrees to provide exhibit space and may acknowledge EXHIBITOR in activity announcements. PROVIDER reserves the right to assign exhibit space or relocate exhibits at its discretion.

By signing below, I agree to the “Terms and Conditions” outlined on Page 1 of this Exhibitor Agreement (including ACCME Standards for Commercial Support): The person signing below is authorized to enter into this agreement: Exhibitor Representative Name Signature Date Mayo Clinic Representative Name Signature Date

PAYMENT INFORMATION Please indicate your method of payment:

PROVIDER Federal Tax ID number is 86-0800150. Please remit check payable to: Mayo Clinic Arizona. Please identify name of course on the check stub.

☐ Check ☐ Credit Card or Wire Transfer Make payable to Mayo Clinic Arizona and remit to: Mayo Clinic School of Continuous Professional Development Attn: Kristy Badder 13400 East Shea Blvd. Scottsdale, AZ 85259 Please identify course 18S05119 on the check.

For payment by credit card or wire transfer, please call the MCSCPD Registrar at 480-301-4580 Do not send credit card information via email or fax.

Complete and return this form along with your payment made to Mayo Clinic Arizona, Federal Tax ID# 86-0800150 to:

Mayo Clinic School of Continuous Professional Development

Attn: Kristy Badder 13400 East Shea Blvd. Scottsdale, AZ 85259

T: 480-301-4580 F: 480-301-9161

Page | 1

Updates in Cardio-Oncology: Challenges and New Frontiers

February 1-3, 2018

Program Schedule Thursday, February 1, 2018

7:00 a.m. Registration & Continental Breakfast

7:45 Welcome Announcements

CANCER, THE HEART, THE VESSELS: RECOGNITION OF AN EMERGING SPECIALTY Moderators: Farouk Mookadam, M.B., B.Ch. and Donald W. Northfelt, M.D. 8:00 Cardio-Oncology: The Journey Paved with Echocardiography

A. Jamil Tajik, M.D.

8:30 Cancer Survivorship: Scope of the Problem Donald W. Northfelt, M.D.

8:50 Cardiac Injury Overview Farouk Mookadam, M.B., B.Ch.

9:10 Cardiovascular Care of the Cancer Survivor Carolyn M. Larsen, M.D.

9:30 Q&A Panel A. Jamil Tajik, M.D., Donald W. Northfelt, M.D., Farouk Mookadam, M.B., B.Ch., Carolyn M. Larsen, M.D.

9:50 Break

10:20 How to Get Started with Cardio-Oncology Joerg Herrmann, M.D.

10:40 AL Amyloid: State of the Art Diagnosis and Treatment Martha Grogan, M.D.

11:00 Getting to the Heart of the Matter: Cardiac Complications of Bone Marrow Transplant Jeanne M. Palmer, M.D.

11:20 Q&A Panel Joerg Herrmann, M.D., Martha Grogan, M.D., Jeanne M. Palmer, M.D.

11:40 Lunch

Page | 2

Thursday, February 1, 2018 (continued)

EXERCISE, DIET, DRUGS, AND SUPPLEMENTS Moderators: Farouk Mookadam, M.B., B.Ch. and Reza Arsanjani, M.D.

12:40 p.m. Exercise for the Prevention of Cardiac and Skeletal Muscle Toxicity of

Anthracycline Chemotherapy Siddhartha S. Angadi, Ph.D.

1:00 Great, Exercise is Good: How Do I Get My Patients to Do It? R. Todd Hurst, M.D.

1:20 Transthyretin Cardiac Amyloidosis: Stop Missing It! Martha Grogan, M.D.

1:40 Hypertension and its Challenges in the Cancer Patient Sandra M. Herrmann, M.D.

2:00 The Truth: Aspirin and Statin. Does it Really Prevent Cardiovascular Disease? Does it Really Prevent Cancer? R. Todd Hurst, M.D.

2:20 Q&A Panel Siddhartha S. Angadi, Ph.D., R. Todd Hurst, M.D., Martha Grogan, M.D., Sandra M. Herrmann, M.D.

2:40 Break

3:10 Advanced Cardiac Imaging in Cardio-Oncology: Why and When? Hector R. Villarraga, M.D.

3:40

Oncologic Therapies with Cardiac or Vascular Toxicity Risks Eric J. Yancey, Pharm.D., R.Ph.

4:00 Radiation and Valvular Heart Disease Susan Wilansky, M.D.

4:40 Q&A Panel Hector R. Villarraga, M.D., Eric J. Yancey, Pharm.D., R.Ph., Susan Wilansky, M.D.

5:00 Adjourn

Page | 3

Friday, February 2, 2018

7:00 a.m. Continental Breakfast

7:50 Announcements

CARDIO-ONCOLOGY: VASCULAR ASPECTS Moderators: Farouk Mookadam, M.B., B.Ch. and Javid. J. Moslehi, M.D. 8:00 Vascular Toxicities of Novel Cancer Therapies

Javid. J. Moslehi, M.D.

8:20 Cardiovascular Stress Testing in the Cancer Patient Carolyn M. Larsen, M.D.

8:40 Clinical Outcome in Patients with Cancer-Related Venous Thromboembolism Treated with Novel Anticoagulants: Thrombophilia Clinic Registry Data Waldemar E. Wysokinski, M.D., Ph.D.

9:00 VTE in Cancer: What are the Optimal Therapeutic Options? Fadi E. Shamoun, M.D.

9:20 Immune-checkpoint Inhibitor Associated Myocarditis: A New Clinical Entity in Cardio-Oncology Javid. J. Moslehi, M.D.

9:40 Q&A Panel Javid. J. Moslehi, M.D., Carolyn M. Larsen, M.D., Waldemar E. Wysokinski, M.D., Ph.D., Fadi E. Shamoun, M.D.

10:00 Break

ONCOLOGIC ISSUES Moderators: Donald W. Northfelt, M.D. and Farouk Mookadam, M.B., B.Ch. 10:30 Myeloma and the Heart

Joseph R. Mikhael, M.D.

10:50 Cardiac Tumors Mahesh Seetharam, M.D.

11:10 Anthracyclines Donald W. Northfelt, M.D.

11:30 Periprocedural Management of Anticoagulation for Patients with Cancer Waldemar E. Wysokinski, M.D., Ph.D.

11:50 Q&A Panel Joseph R. Mikhael, M.D., Mahesh Seetharam, M.D., Waldemar E. Wysokinski, M.D., Ph.D.

12:10 p.m. Lunch

Page | 4

Friday, February 2, 2018 (continued)

CARDIO-ONCOLOGY: ECHOCARDIOGRAPHY Moderators: Farouk Mookadam, M.B., B.Ch., Steven J. Lester, M.D., and Reza Arsanjani, M.D. 1:10 2D, 3D and 4D Echocardiography

Reza Arsanjani, M.D.

1:30 Strain, Speckle, VVI Steven J. Lester, M.D.

1:50 ASE Standard Chamber Quantification Ronald J. Buono, R.D.C.S.

2:10 SPECKLES: How To Christopher B. Kendall, R.D.C.S.

2:30 Q&A Panel Reza Arsanjani, M.D., Steven J. Lester, M.D., Ronald J. Buono, R.D.C.S., Christopher B. Kendall, R.D.C.S.

2:50 Adjourn

Echocardiography Hands-on Workshop (separate registration required; refreshments served) 3:00 Echocardiography Workshop

Farouk Mookadam, M.B., B.Ch., Steven J. Lester, M.D., Reza Arsanjani, M.D., and Matt M. Umland, R.D.C.S., F.A.S.E.

5:30 Adjourn

Page | 5

Saturday, February 3, 2018

7:00 a.m. Continental Breakfast

7:30 Announcements

RADIATION AND THE HEART Moderators: Reza Arsanjani, M.D., Lisa A. McGee, M.D., and Jonathan B. Ashman, M.D., Ph.D. 7:40 Proton Beam Therapy: Current Data and Future Directions

Lisa A. McGee, M.D.

8:00 Radiation-Induced Cardiotoxicity: What Do We Know? Jonathan B. Ashman, M.D., Ph.D.

8:20 Defining Radiation Mediated Cardiac Toxicity Carlos E. Vargas, M.D. and Joshua R. Niska, M.D.

8:40 VATS and Pericardial Disease in the Cancer Patient Dawn E. Jaroszewski, M.D.

9:00 Constriction as a Consequence of Cancer Therapy Christopher P. Appleton, M.D.

9:20 Managing Recurrent Pericardial Effusion in the Cancer Patient William K. Freeman, M.D.

9:40 Q&A Panel Lisa A. McGee, M.D., Jonathan B. Ashman, M.D, Ph.D., Carlos E. Vargas, M.D., Joshua R. Niska, M.D., Dawn E. Jaroszewski, M.D., Christopher P. Appleton, M.D., William K. Freeman, M.D.

10:00 Break

SPECIAL TOPICS Moderators: Farouk Mookadam, M.B., B.Ch., Eric H. Yang, M.D., and Siva K. Mulpuru, M.D. 10:20 QT Prolongation and Oncology Medications

Siva K. Mulpuru, M.D.

10:40 Left Atrial Appendage Occlusion Eric H. Yang, M.D.

11:00 Atrial Fibrillation/Anticoagulation: What to Do in Cancer Patients Reza Arsanjani, M.D.

11:20 Advanced Therapies for Chemocardiomyopathy Brian W. Hardaway, M.D.

11:40 Q&A Panel Siva K. Mulpuru, M.D., Eric H. Yang, M.D., Reza Arsanjani, M.D., Brian W. Hardaway, M.D.

12:00 Adjourn