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Marini 2004Marini 2004
www.vaccinationcouncil.org
This vaccine webinar series is provided as a community service by Homefirst Natural Pharm
Source www.homefirst.com
Marini 2004Marini 2004
A Medical School Professor A Medical School Professor of Immunology’s Lesson for of Immunology’s Lesson for
All PhysiciansAll PhysiciansNEUROIMMUNOLOGY PATTERNS OF INTERFERENCENEUROIMMUNOLOGY PATTERNS OF INTERFERENCE
Stephen C. Marini, M.S., D.C., Stephen C. Marini, M.S., D.C., Ph.DPh.D
Stephen C. Marini, M.S., D.C., Ph.DStephen C. Marini, M.S., D.C., Ph.DFamilyFamily
Chiropractic CenterChiropractic Center3301 Ryan Avenue3301 Ryan Avenue
Philadelphia, PA 19136Philadelphia, PA 19136Tel: (215) 332-8686Tel: (215) 332-8686Fax: (215) 332-8691Fax: (215) 332-8691
Ciccarone Chiropractic & Rehab Centers144 East DeKalb Pike, Suite 202King of Prussia, PA 19406Tel: (610) 337-3555Fax: (610) 337-8235E-Mail: [email protected]
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CHANGING PARADIGMS
Mechanistic:
CHEMISTRY STRUCTURE FUNCTION
Vitalistic:
ENERGY FIELD CHEMISTRY STRUCTURE UNIFIED FIELDS FUNCTION
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Immune System
HumoralImmunityAntibodies
Cell-Mediated ImmunityCellular CytotoxicityDTH
T HelpersCytokines
Antigen-presentingCells
ReticuloendothelialSystem
Stem cells,Cytokines
HaemopoieticSystem
Neuro-endocrineSystem
The Current Consensus Model of the Immune System and Its Relationship to the Neuroendocrine System
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Regulation of Immune Responses and the Involvement of Other Systems
Immune System
PositiveRegulatorsT Helpers
Cell-MediatedImmunityCellular CytotoxicityDTH
HumoralImmunityAntibodies
NegativeRegulatorsT Suppressors
Reticulo-endothelial
System
HaemopoieticSystem
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OPTIMUM IMMUNITY
THE HUMAN IMMUNE SYSTEM: YOUR MOST RESPONSIVE ALLY
PNI (Psychoneuroimmunology)
PSYCHO – Experience, Interpretation, Translation, Transformation, Mind, Thoughts, Feelings, Notions, Memory, Opinions, Spirit, Soul, Energy-information, Unified Fields
NEURO – Brain (right and left), Spinal cord, Cranial nerves, Spinal nerves, Autonomic nervous system, Memory, Neurotransmitters, Neuropeptides, Neurohormones, Interference by the VSC (Vertebral Subluxation Complex)
IMMUNO – Central and peripheral lymphoid organs, T cells, B cells, Antigen processors, Lymphokines, Cytokines, Neurochemicals, Memory
GASTROENTERO – Gut associated lymphoid tissues, Lymphokines, Neurotransmitters, Breast feeding, Oral tolerance, Memory, Gut reactions
MUSCULOSKELETAL – Receptors, Biomechanics, Posture, Memory, Spinal Learning, Interference from VSC, Exercise Neurochemistry
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Rationale For ImmunizationRationale For Immunization
Immunoprophylaxis/Primary Prevention
Herd Immunity
Pre & Post Exposure Immunization
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TYPES OF IMMUNITY & TYPES OF IMMUNITY & IMMUNIZATIONIMMUNIZATION
Active
Passive
Natural
Artificial
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T HELPER CELL SUBSETS Th 1 Cells (CD4+)
These cells mediate functions connected with cytotoxicity and local inflammatory reactions. Th 1 cells promote development of Tc Cells, the expression of the delayed hypersensitivity, and the production of 1gG2a.
This subset secretes gamma interferon, interleukin 2,3 tumor necrosis factor, lympotoxin, and antibody mediated cell cytotoxicity. Regulation of the Th 2 reactions.
Th 2 Cells (CD4+)
This subset directs immune responses toward production of IgE (atopic diseases), IgA, IgG1.
Eosinophil proliferation via interleukin 5, and mast cells via Il-3 and 4. Th 2 cells secrete Interleukin 3,4,5,6,10. Interleukin 4,5,6 stimulate antibody production.
The Th subsets down-regulate one another1. Gamma interferon secreted from Th 1 cells suppresses the maturation of Th 2 cells
and suppresses the enhancing effect of IL-4 produced by the Th 2 cells on IgE and IgG1 – synthesis
2. IL-10 secreted the Th 2 cells suppresses production of Th 1 cells3. Il-10 possesses cross-regulatory role of inhibiting cytokine synthesis by Th 1 cells
IMMUNOGENS ELICITING A STRONG CELL MEDIATED RESPONSE WILL INHIBIT HUMORAL ACTIVITYSTRONG HUMORAL RESPONSES INHIBIT CELL MEDIATED RESPONSES TO THE SAME ANTIGEN
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Ab Titer vs. Time
Time
Ab
Tit
er
Ab Titer Values
Th2 Humoral Immune Response
Ab Titer Values
Time
Ab
Tit
er
Ab Titer Values
Th1 Cell-Mediated Response
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Prenatal Skewing toward Th2• Natural
• Artificial/Environmental
Neonatal/Infantile Th1 Stimuli•Birth Canal Flora
•Colostrum
•Breast Milk
•Prebiotics
•Probiotics
•Environmental exposure
•Viruses
•Gram negative bacteria
•Fungi
Neonatal/Infantile Inhibitors to the Th1/Th2 Balance
•C Sections
•Vaccinations
•Antibiotics
•Formula Feeding
•Dysbiosis
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JOURNAL ARTICLEISSN
0367-6102Country of Publication
JAPANDatabase: med93-95 – Record 2 of 4 selected.Title
Vaccine strategies: targeting helper T cell responses.Author
Golding B; Scott DEAddressLaboratory of Plasma Derivatives, United States Food and Drug Administration, Bethesda, Maryland 20892, USASource
Ann N Y Acad Sci, 754(-VI-):126-37 1995 May 31AbstractVaccine strategies need to take into account the balance of T helper subsets they induce. TH1 cells, which secrete IFN gamma and IL-2, are associated with CMI, rather than humoral responses, and afford protection against intracellular infections including parasites. In contrast, TH2 cells secrete IL-4, IL-5, and IL-10; elicit high-titer antibody responses and poor CMI; and are associated with susceptibility to infection with intracellular pathogens. Depending on the type of TH cell bias required, it is possible to manipulate the immune response to a protein or peptide by employing (1) different adjuvants, (2) conjugating the protein to various carriers, (3) immunizing in the presence of cytokines, (4) using alternative routes of administration, or (5) using different forms or doses of antigen. To apply these approaches to a particular vaccine, it is necessary to identify which component of the infection agent (e.g., envelope protein or peptide) or allergen to target. Once the type of TH cell response that is protective is identified, it may be possible to combine a protein with an adjuvant or link it to a carrier that will promote responses towards the most advantageous TH subset.
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A. Antibody Response following Immunization
PRIMARY & SECONDARYIMMUNE RESPONSES
ANTIBODY FORMATION
Ab Concentration
1* Response 2* Response
195
75
IgM
IgG
5 10 15 20 25 30 35 40 45
DAYS
Characteristic Primary Response vs. Secondary ResponseDose of Immunogen Required >Induction Period <Total Antibody Produced <Duration of Response <IgM antibody produced =IgG antibody produced <
1. A summary of the solvent features of the primary & secondary immune responses
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VACCINE TYPES
Whole Organisms (Bacterial)Live Attenuated Inactivated
Tuberculosis (BCG) AnthraxTyphoid Cholera
PertussisPlagueViral Particles
Live Attenuated InactivatedMeasles Hepatitis AMumps InfluenzaRubella Polio (IPV) SalkPolio (OPV) Sabin RabiesVaricellaYellow FeverRotavirus
Purified Macromolecules
Toxoids (Inactivated Exotoxin)
DiphtheriaTetanus
Capsular PolysaccharidesHaemophilus influenza, Type B
(HIB)Neisseria MeningitidesStreptococcus Pneumoniae
Surface AntigensHepatitis B (Recombinant
surface antigen)HbsAg
DNA Vaccines/Genetically Engineered Satellite DNA
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TYPICAL COURSE OF AN AUTISTIC PATIENT1. Hepatitis B immunization at 12 hours after birth. DPT immunization at 4 and 8 weeks*,
oral polio immunization also at 4 and 8 weeks, again at 3 months. Schedule now being changed; children will receive 2 doses of live attenuated oral polio and 2 doses killed polio; oral polio can cause disease; only killed polio is used in Europe.
2. Because of great decrease in cell-mediated immunity (CMI) in infants, the vaccines lower CMI further; one decreases CMI by 50%; two together by 70%. Longest safety trail of the triple vaccine (MMR, all live attenuated viruses) was three weeks.
3. Repeated immunizations with 3 vaccines simultaneously, e.g., Pneumococcus, Haemophilus, etc. from 4 weeks to 12 to 18 months. Repeat DPT is given at 12 months. *All these triple vaccines markedly impair CMI.
4. Resultant decrease in CMI predisposes to recurrent viral infections, especially otitis media, since CMI controls response to viruses (also fungi [e.g., Candida], parasites [e.g., leishmaniasis], mycobacterium [e.g., tuberculosis, even if drug resistant] and leprosy).
5. When infections occur, bacterial cultures rarely performed, yet infants repeatedly given antibiotics. Antibiotics are of absolutely no help in viral infections; in some countries, antibiotic administration without a prior culture is considered malpractice.
6. Antibiotics wipe out helpful bacteria in the gut (e.g., lactobacilli, bifidobacteria), which have important protective functions, including prevention of infection by yeast, pathogenic bacteria, and/or parasites. The protection is provided in part by the helpful bacteria clinging to the intestinal cell wall, thus preventing pathogenic microorganisms from getting to it. The pathogenic bacteria compete with the body for vitamin B-12 and perhaps other vitamins and minerals.
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Breast FeedingBreast Feeding (PNIEG) -(PNIEG) - PSYCHO-PSYCHO- NEURO-NEURO- ENDOCRINO-ENDOCRINO- IMMUNO-IMMUNO- GASTROINTESTINO-GASTROINTESTINO- NUTRITIONNUTRITION
• BREAST MILK vs. FORMULABREAST MILK vs. FORMULA TOXICITYTOXICITY
• MOTHER – FETUSMOTHER – FETUS• MOTHER - BABYMOTHER - BABY
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Marini 2004Marini 2004
Marini 2004Marini 2004
IMMUNIZATION QUESTIONSAND ISSUES
1. Are vaccines effective? Temporary immunity/deferred susceptibility.
2. Are vaccines safe?Doctors, legislators, parents not informed.
3. Informed consent or conscription?
4. Avoid vaccine reactions by asking:• Is my child sick right now?• Do I know if my child is at risk?• History in family of vaccine reactions or health problems?• Do I know the adverse reactions to the vaccines given to my child?• Do I know the manufacturer and lot number of the vaccine?• Do I know how to report an adverse reaction?
5. Do I know my rights under the state law to exempt my child from vaccines?
6. If I choose not to vaccinate my child, do I know how to recognize and appropriately manage illnesses that vaccines protect against?
Marini 2004Marini 2004
CURRENT VACCINATION CONCERNS
1. Emergency State Powers Act
2. State Registry
3. Exemptions Under the Law
4. Thimerosal and Vaccines
5. Autism and Vaccines• Mercury Induced• Autistic
Enterocolitis• Immune Complex Disorder
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Marini 2004Marini 2004
ImmunostasisTh1/Th2 Balance
High Ratio FXNCMI (Cell Mediated Immunity)
Surveillance
Tolerance
Cytotoxicity
Infection Externalization
Intracellular Infection
Th1 Up Regulators
Welfare Consciousness Patterns
Antioxidants
Glucans & Mushroom Extracts
Melatonin
DHEA (Dehydroepinandrosterone)
Selenium, Zinc
Probiotics
Breast Feeding
Fish Oils
Beta Sterols (Beta-sitosterol & sterolin)
Viral and Bacterial Inf.
Dirt, Dust, Dander
Th2 Up Regulators
Vaccinations
Antibiotics
Emergency Consciousness
Sympathetic Activity+HPAC
Purulent & Parasitic Infection
Trans & Saturated Fats, 6EFA
Oxidation Damage
Mercury Toxicity
Nicotine and Caffeine
Progesterone
Sugar
Environmental Toxins, Hormones, Pesticides, Diesel Fumes
Food Deprivation
Low Ratio FXN
Humoral Immune
Atopic Dermatitis
Allergies & Asthma
Eczema/Psoraisis
Infection Internalization
Toxin Neutralization
Extracellular Infection
System Autoimmunity (Lupus, Graves, Type II Diabetes, RA)
Cancer
AIDS
Marini 2004Marini 2004
MAP OF CONSCIOUSNESS God-view Life-View Level Log Emotion Process
Self Is Enlight- 700- Ineffable Pure Con- Enment 1000 sciousness All-Being Perfect Peace 600 Bliss Illumination
One Complete Joy 540 Serenity Transfiguration Loving Benign Love 500 Reference RevelationWise Meaningful Reason 400 Understanding Abstraction
Merciful Harmonious Acceptance 350 Forgiveness Trans- cendence
Inspiring Hopeful Willingness 310 Optimism IntentionEnabling Satisfactory Neutrality 250 Trust Release
Permitting Feasible Courage 200 Affirmation Empowerment Indifferent Demanding Pride 175 Scorn Inflation
Vengeful Antagonistic Anger 150 Hate Aggression Denying Disappointing Desire 125 Craving Enslavement
Punitive Frightening Fear 100 Anxiety WithdrawalDisdainful Tragic Grief 75 Regret Despondency
Condemning Hopeless Apathy 50 Despair AbdicationVindictive Evil Guilt 30 Blame DestructionDespising Miserable Shame 20 Humiliation Elimination
POWER VS. FORCE David R. Hawkins, M.D.,Ph.D.
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Health
Interference
Patterns of Interference
Symptoms
Symptom Constellations
Disease
Dis-ease
Marini 2004Marini 2004
HEALTH CARE ERAS
Era IChemical, Mechanical, material or physical medicine
Described by being causal, deterministic, hierarchical, bound to classical concepts of space-time. Mind is not a factor; mind is purely the result of brain mechanisms.
Examples are any form of therapy focusing solely on the effects of things (chemical or physical) on the body. Almost all forms of modern allopathic-drugs, surgery, irradiation, etc.
Marini 2004Marini 2004
Era IIMind-Body medicine. The role of energy/information on the physical-chemical body is embraced.
Described by the mind being a major factor in healing WITHIN the single person; mind has causal powers. Healing not fully explainable by classical concepts of science. Era 2 includes but goes beyond Era 1.
Examples are any therapy, which has the patient as the focus, complementary approaches are incorporated. Therapies emphasizing the effect of consciousness solely within the individual body: psychoneuroimmunology, chiropractic, hypnosis, homeopathy, acupuncture, biofeedback, relaxation therapies, therapeutic touch, and imagery based therapies.
Marini 2004Marini 2004
Era IIINon-local therapy or Eternity Medicine
Described by the mind factoring into healing both WITHIN and BETWEEN persons. Mind not completely localized to points in space (brains or bodies) or time (present moment or single lifetimes). Mind is unbounded in space and time and is ultimately unitary or one. Distance healing possible. Not explainable by classical concepts of space-time or matter-energy.
Examples are any therapy in which effects of consciousness bridge between different persons: all forms of distant healing, intercessory prayer, and transpersonal imagery.
DISEASES ARE SEEN AS IMBALANCES TO BE CORRECTED. IMBALANCES AFFECT THE ENTIRE PERSON (BOTH THE PHYSICAL BODY AND THE ENERGY BODY). IMBALANCES HAVE THE CAPACITY OF AFFECTING THE INDIVIDUAL AS WELL AS THOSE LINKED BY ENERGY. PROPER HEALING NECESSITATES BALANCING ENERGY AS WELL AS CHEMISTRY AND STRUCTURE OF THE BODY. HEALTH AND HEALING CAN BE AFFECTED BY ENERGY/INFORMATION FROM A DISTANCE. PRAYER HAS BOTH A LOCAL AND NON-LOCAL EFFECT ON THE MIND-BODY.
Marini 2004Marini 2004
HEALTH CARE ERAS
ERA I MEDICINE: Allopathic Therapies
Paradigm: CHEMISTRY ↔ STRUCTURE ↔ FUNCTION
ERA II MEDICINE: Holistic/Holoenergetic Therapies
Paradigm: ENERGY ↔ CHEMISTRY ↔ STRUCTURE ↔ FUNCTION
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ERA III MEDICINE: Intercessory Therapies
Paradigm:UNIFIED ↔ ENERGY ↔ CHEMISTRY ↔ STRUCTURE ↔ FUNCTION FIELDS