ecor U.S. DEP ARTMENT OF

H EALTH EDUCATION. AND W E L FARE !\larch 18, 1969 Vol. XXI, No. 6

Dr. W. Henry Sebrell, Jr. Honored for Contributing To Nutrition Programs

Dr. W. Henry SebreJl, Jr., Di­rector of the Institute of Nutrition Sciences at Columbia University, has been presented an award by Research CorpoTation, a founda­tion for the advancement of sci­ence, for his contributions to its public health nutrition program.

For 13 years Dr. Sebrell has been chairman of the foundation's Wil­liams-Waterman Fund Committee which was established by a gift of patent royalties from the in­ventors of vitamin B,.

Saved Many Lives

In the resolution, presented by Dr. James S. Coles, president of Research Corporation, Dr. Sebrell was cited for his efforts which "have saved liwrally tens of thou­sands of lives, and have improved the quality of life in many na­tions of the world."

Dr. Sebrell started his profes­sional career in 1925 with the U.S. Public Health Service. He was Assistant Surgeon General and Di­rector of NIH when he retired in

Dr. Jack Masur, Clinical Center Director, Dies Suddenly; Joined PHS in 1943

In Me mariam

The sudden death of Dr. Jack Masur, Din,ctor of t he Clinic,d Cen­ter, March 8 has saddened all of NIH.

Expressions of sympathy and sorrnw have poured in from friends and professional colleagues here at NIH and elsewhere. rank of Assistant Sm·geon General

Dr. Masur, closely associated of the 1:J.S. Pub~ic Health Service with the Clinical Center since its at the time of his death. beginning also served as NIH Well known in the fields of hos-

1955. Associate' Director for Clinical pita! administration and hospital (See DR. s1mnF:U,, !'ayes) Care Administi-ation and held the planning and construction, Dr.

- -------------- ---- ---- --• ----- Masur joined the PHS in 1943 and Congressional Cabinet Wives Visit NIH, held a variety of responsible posts.

He served as Director of the

Hear Dr. Marston, Tour cc Facilities Clinical Center in the development of plans and programs for the re-

More than 40 wives of Cabinet officers, Congressmen and Adminis­tration officials visited the National Institutes of Health' Feb. 28 as the guests of Dr. Robert Q. Marston, N IH Director.

The visit was arranged by Mrs. William A. Steiger of Wisconsin

Mrs. Marstan "daes the hanors" for Mrs, Finch during the coffee haur un­der the chee rful gaze of (from left) Mrs. Steiger, Mrs. Laird, and Mrs. Bush.

and Mrs. George Bush of T exas, program chairmen of the Repub­lican Congressional 'Wives, to fa. miliarize themselves with research and 1·elated activities at NIH and to tom· the Clinical Center's fa­cilities.

The Congressional group, open to all wives of Republican Sena­tors and Representatives, is head­ed currently by Mrs. Peter H. Dominick of Colo1·ado. Tt meets on a monthly hasis from Januarv through June with the expres~ purpose of becoming better in­formed about the activities and operations of the va·rious Govern­ment departments and agencies.

Among the guests were: Mrs. Robert H . Finch, wife of

(Sea CONGRESSIONAL, Page 3)

search hospital which opened in 1953 to provide facilities for pa­tient care, clinical investigation, and laboratory research for NIH.

As chief of the Bureau of Medi­cal SeTvices from 1951 to 1956, Dr. Masur directed the PHS medical care program. He administered its USPHS hospitals, Indian health programs, Hill-Burton program, foreign quarantine and other medi­cal activities.

The H ill-Burton program , through which Federal grants are made to the states for hospital construction, is one t hat received support and impetus from Dr. Masur since it is one of the means of improving hospital service and care.

In 1956 Dr. M.asur returned 1,o NIH bo serve again as CC Director. Subsequently he was appointed As­sociate Director of NIH for Clinical

(See DR. MASUR. Pan• 6)

NAT I O N A L I N STITUT ES O F H E ALTH

Dr. Donald S. Fredrickson Named Heart lnstitute's Dir. Intramural Research

Dr. Donald S. Fredrickson was 1·ecently named Director of Intra­mural Research, National Heart Institute. Dr. Theodore Cooper, Director of NHI, announced the appointment .

Dr. Fredrickson will be charged with overall planning, direction and coordination of the Heart In­stitute's intramural cardiovascular research programs. He will con­tinue as chief of the Molecular Disease Branch.

Left Post for Resen rch

A member of the NHI scientific staff since 1953, he served as Di­rector of the Heart Institute from 1966 until 1968; he left th is post in order to devote m<1re time to research.

Dr. Fredrickson's research a t NHI has earned him international recognition as an authority on fat trnnsport in the ci rculation and on th<' diseases of lipid metabolism.

He has conducted and directed labon,tory and clinical research on the »tructure of plasma lipopro­teins, their role in fat transport, and on genetic factors that r egu­late lipoprotein metabolism.

His studies of heritable diseases of fat storage and metabolism in­cluded the discovery of the Jipopro­tein deficiency s tate, Tangier dis­ease, and establishment of its mode of inheritance.

(See DR. FREDUJCKSON. !'ape 8)

Dr. Jack Masur

Page 2 March 18, 1969

ecord Published biweekly at Bethesda, Md., by the Publications and Reports Branch, Office of Information, for the information of employees of the National Instit utes of Healt h, Department of Health, Education, and Welfare, and circulated by r equest to interested writers and to investi­gators in the field of biomedical and related r esearch. The content is reprintable without permission. Pictures are available on request.

The NIH Record reserves t he right to make corrections, changes or dele­tions in submitted copy in conformity with the policies of the paper and the Department of Health, Education, and Welfare.

NIH Record Office .. . ............ ..

Editor .... .. . Assistant Editor

Bldg. 36, Rm. 1 C-18. Phone: 49-62125

Fro nces W. Davis .. Fay l e viero

Staff Correspondents

Tony Anastasi, DRS; Ba.ri Attis, NINDS; Lloyd Blevins, NICHD; Thomas Bowers, CC ; George Bragaw, NHI; Katie Broberg, NIAMD; Lav.n:ence Chamblee and Florence Foelak, BEMT; .Jan Clagett, FIC; Gladys Ganley, DCRT ; Sue Hannon, NIDR; Marjorie Hoaglund, NIMH; Sheila Jacobs, NCI ; Elizabeth Y. J ames, NIEHS; John P . Kelly, NLM; Marion Oakleaf, DRG; Faye Peterson, DRS; Ric1rnrd Schroder, ADA; Jane Shure, NIAIU; Wanda Wanldell, N IGMS.

CC Blood Bank Receives 149 Units of Blood in Feb.

The Clinical Center Blood Bank reports t hat 149 units of blood were received from NIH donors in February, and CC patients received 1,673 units of blood.

Twelve donors achieved a special status. Dr. Micah Kri­chevsky, NIDR, reached the 3-gallon mark, and Ralph E. Williams, OD, attained the 2-gallon mark.

Joining the Gallon Donor Club were: Richard J. Dugas and Harold P. Simpson, OD; Patricia A. Cliggett, CC; Mar­vin Kat;,;, DCRT; Ray D. Crossley, DBS; Jirina H. Chapin, DRS; Dr. ,Joseph V. Michalski, l\IAMD; Dr. Stan­ley Handmaker, NIDR; Fred Ederer, NHI, and Jacqueline Van de K,.mp, NLM.

Why not join them? Make an appointment now to give blood. Call the CC Blood Bank, Ext. 64506.

Course in Basic Sailing To Begin Here Tonight

The R&W Sailing Association is sponsoring a 9-week course in basic sailing. It will be conducted ever y Tuesday by ,the Coast Guard Aux­iliary Flotilla 71.

The course starts today (Tues­day, March 18) at 8 p .m., in the first floor Conference Room, Bldg . 30, and will be held weekly, same day, time and place.

Interested NIH personnel may sign up in the R& W office. Fo1· further information call Bill Sang­er, Coast Guard Auxiliary, code 18-34191.

Teresa W. Kean Retires, With Gov't 26 Years

Te resa Keon receives gilts ond con­gratulations from Dr. George Z. W il­liams, chief, Clinical Pothology De­partme nt (r), ond Dr. Ernest Cotlove, deputy chief, at re tireme nt party.

After 2G years of Federal serv­ice, Teresa \V. Kean, secretary to Dr. Ernest Cot lovc, deputy chief of the Clinical Pathology Department, Clinical Center, recently retired.

She has been with CC for the past 9 years.

Shortly afber she joined the Clin­ical Pathology Department, t he de­velopment of its automated labora­tory systems started. Mrs. Kean, t hen a newly appointed secretary, was faced with inc1·eased responsi­bilities.

She recalls those days as a hectic period. So for r elaxation, in the evenings, she took up painting. She is a devotee of M't and a former art student.

When she felt that her paintings were suitable for display, she hung several of them on her office walls. They added a colorful backdrop to office surroundings, and delighted her co-workers and the patholo­gists and scientists who visit the department.

Mrs. Kean has s0ld several of

Katharine Parent Dies: Former DRG Analyst Pioneer on Patents

Katharine A. Parent, a member of the Division of Resear ch Grants staff for 20 years, died March 5 in Suburban Hospital, Bethesda, Md. after a heart attack

As one of the initial staff mem­bers of the Division, Miss Parent assisted in the establishment, in 1946, of its research grants pro­gram.

During the t ime she was at DRG, Miss Pa<rent held various respon­sible positions. She served as a program analyst to coordinat e study section activities, a special assistant for patents, executive secretary of the former Primate Reseaa·ch study section, and con­ference coordinator.

She was well known by univer­sity and hospital officials through­out the United States, particularly because of her pioneering work in the development of institutional patent agreements.

In March 1967 she transferred to the Office of the Surgeon Gen­eral as assistant to t he director, Grants a nd Contracts Division.

Miss Parent is survived by sev­eral n ieces and nephews in the Cleveland, Ohio, area.

Sixteen HEW Employees Reach Blood Donations Of One to Five Gallons

Sixteen HEW employees received Red Cross ce1-tifica,tes in a recent ceremony honoring those who had made blood donations totalling a gallon or more.

The program was administered by the Bureau of Health Profes­sions Health Education and Man­power T,·a ining fu1· a ll HEW units in the Ballston Center complex.

Honored at the ceremony were: (5 gallons) Mel White, BEMT; (3 gallons) Doris Adams, Health Services and Mental Health Ad­ministration; and (2 gallons) Ce­cilia Barnes and J on Rasmussen, HSMHA; John E. Carrell, Ronald Merrill, and Paul Panneton, BEMT, and Barnett Perler, Social Security Administration.

One gallon donors were: Charles Bennett, SSA; Gordon Berg, Rose Ferrett, Michael J. Geaney, and William F . Lewis, HSMHA, a nd .Joel Hedetnimi, Rita C. Jenkins, and Joseph Kadish, BEMT.

her paintings. She belongs to t he Montg,omery County Art Associa­tion and has shown examples of her work in several of their ex­hibits. She now plans to devote more time to heo: art.

More t han 50 friends and co­workers attended her r ecent retire­ment party. Among t he gifts pre­sented to Mrs. Kean was Frederick Taub's book on oil painting.

THE NIH RECORD T: !!!!

NIH Television, Radio Program Schedule

Television

NIH REPORTS

WRC, Channel 4 Sundays-3:55 p.m.

March 23 Dr. J ohn M. Van Buren,

associate neurology sur­geon, Surgical Neurology Br anch, N INOS

Subject: Surgical Aid in Pa1·ki nsonism

March 30 Dr. Alfred M. Sadler, J r .

and Blair L. Sadler, NIH Subject: Medical and Legal

Aspects of Organ Trans­plants

Radio

DISCUSSION: NIH

WGMS, AM-570- FM Stereo 103.5-Friday Evenings­About 9:15 p.m.

March 21 Dr. Martin M. Cummings,

Di1·ector, NLM Subject: The National Li­

brary of Medicine

March 28 Dr. Edward Graykowski,

NIDR Subject: Research in Oral

Ulcerations

Both interviews take place during intermission, Library of Congress Chamber Music Series.

Dr. D. A.H. Taba, WHO, Visits NIH and Other U. S. Health Facilities

Dm·ing a recent visit to this country Dr. D. A. H. Taha, r e­g ional director of the World Health Organization for the Eastern Medi­terranean, was t he featured speak­er at the International Meeting of the Association of American Medi­cal Colleges.

Schedule Arranged

Dr. Taba's schedule was arranged by the Foreign Students Educa­tion B1·anch of the Division of

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H He a It h Manpower Educational N Services, Bureau of Health Profes­sions E<lucation a nd Manpower Training. tu

of He attended the annual meeting of the American Association for Tropical Medicine and Hygiene, visited NIH, and health facilities in California, New York, and Washington.

Dr. Taba, guest of honor at a luncheon at which Surg . Gen. Wil­liam H. Stewart was host , is a former Director-General of Health for Iran.

si re 2~

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THE N IH RECORD

'Gift of Life' Color Film On the Artificial Kidney Scheduled for Television

"Gift of Life," a new film about the artificial kidney, will be shown 011 television for the first t ime.

The 15-minute color film, an NIH "in house" production of t he National Institute of Arthritis and Metabolic Diseases and t he Medi­cal Arts and Photography Branch,

1 Division of Research Services, is scheduled on Channel 26 at 6:30 p .m., Thursday, March 20.

T he film dramatizes the use of artificial kidneys and NI AMD's Artificial Kidney Program.

This program is aimed at the research and developing of sim­pler, more efficient, and less costly dialyzeirs, and to improve patient rehabilitation.

The 16-millimeter motion picture is intended for t elevision outlets, libraries, universities, civic and voluntary health groups, and pro­fessional organizations and school systems.

The film tells the story of "Jeff Winston" who is stricken with kid­ney disease and subsequent per ­manent loss of kidney function.

Treatment Exte nds Life Twice a week he is connected to

an artificial kidney machine in his home to have his blood purified. Without such treatment he would not live.

Shown are several sequences filmed at the artificial kidney cen­ter of the Veterans Administra­

e tion Hospital in Washington, D.C. ~ Here, Dr. Ervin A Gombos, chief of c the Hemodialysis Center, explains

in easy-to-understand t erms how the artificial kidney works.

At the film's conclusion, Dr. Ben­jamin T. Burton, NIAMD associate director for Program Analysis and Scientific Communication and chief of NIAMD's Artificial Kidney P ro­gram, discusses the research of that program.

The motion picture was made - under the supervision of Arthur - Moore, chief, Motion P ictures,

MAPB. Elaine Hamilton, MAPB em­

ployee, her husband Clifford, and their children play leading roles in the film.

- History of Medicine Div., NLM, Receives Award

A C<ilalogue of Sfr;beenth Cen­tu111 Printed Books, a publication of the History of Medicine Divi­sion, National Library of Medicine, r eceived an awaird recently at the 27th Exhibition of Printing.

A certificate of Achievement was presented in the name of the U.S. Government Printing Office- Na­tional Library of Medicine.

The exhibition was sponsored by the Printing Industries of Metro­politan New York.

Mar ch 18. 1969

Following his presentation to the Congressional group, both Dr. Marston ond Dr. Farrie r answe red questions about the NIH, the Clinical Cente r, ond medical research.

CONGRESSIONAL (Ccnrti-nut d. from Page 1)

the HEW Secretary; Mrs. Melvin R. Laird, wife of the De fense Sec­retary and former Representative from Wisconsin; Mrs. Hamel' H. Budge, wife of the SEC Chairman and former Congressman from Idaho, and Mrs. James E. Van Zandt, wife of the former Con­gressman from Pennsylvania.

Mrs. Ann Marston, wife of the NIH Director, assisted by Mrs. Finch, entertained the ladies at a coffee hour in the CC doctors' lounge prior to meeting with Dr. Marston.

Dr. Robert M. Farrier, Associate Dirnctor of the Clinical Center, welcomed the group and introduced Dr. Marston.

In his presentation, Dr. Marston explained the ftmction and opera­tion of NIH, its organization and growth. He pointed out t ha t now the NIH concerns itself not only with 1·esearch and the support of research, but a lso with increasing th1) supply of manpower for health

Mrs. Finch (left) talks with Mrs . Glen­ard Lipscomb of California (cente r) and Mrs, Steiger.

professi.ons and with biomedical communications.

Dr. Marston discussed research, as well as its impact, and how re­search today dramatizes the part­nership between the Federal Gov­ernment, universities and 1-esearch centers, and private industry.

He cited several examples of this, one being tl1e campaign to

Dr. Marston turns to chat with Mrs. Laird prior to the start of the tour of the Clinical Ce nter. Looking on are Mrs. Marston and Mr>. Finch.

find a safe and effective rubella ( German measles) vaccine, and called attention to the recent In­ternational Conference on Rubella Immu nization (see NJH Record, March 4, l!lG!)) held here.

The conference, s ponsored by the National Institute of Allergy and Infectious Diseases, the Divi­sion of Biologics Standards, and New York University, was held to assess p rogress in the develop­ment of a r ubella vaccine. Some 400 scientists from 27 countries attended the conference.

Advances Discussed

In tracing the histo ry of the seaTch for a safe vaccine, Dr. Marston spoke about the many problems involved and advances made in developing a vaccine to prevent the hi rth of abnonnal ba­bies to mothers exposed to r ubel la in the early stages of pregnancy.

About 20,000 babies wer e born in the 1964-65 epidemic, he said, with such crippling defects as mental l'etardation, heart disease, blindness and deafness.

" It is reasonably sure," Dr. Marston told the group, "a vaccine will be licensed in the next few months." The DBS produced the first such vaccine, he noted, and now three vaccines "show a great deal of promise."

The group also viewed a color film and color slides on NIH and the research conducted here.

Page 3

Ors. Meyer and Parkman Receive UCPA Award For Rubella Research

Drs. Harry .M:. Meyer, Jr. and Paul D. Parkman, Division of Bio­logics Standards, 1·eceived the United Cerebral Palsy Associa­tion's Max Weinstein Award for 1968 for their contributions to ru­bella research.

The presentation was made on March 7, 1969 at the Association's annual conference.

Dr. Sidney Fm·ber, Director of Research, Children's Cancer Re­search Foundation, Boston, and chairman of the UCPA Research Steering Committee, presented the award- a silver plaque and $1,000.

Potential Cited

Dr. Farber commented that ru­bella vaccine, when licensed, will have tremendous implications for the prevention of brain damage and congenital defects in the newborn. The major hazard of rubella virus lies in the risk of its transmission to the fetus during pregnancy, re­sulting in such defects.

Drs. Meye,· and Parkman were the first to attenuate the rubella virus. Several pha:rmaceutical man­ufacturers working with thei r at­tenuated strain (HPV-77) have produced experimental vaccines that have been extensively tested in field trials her e and abroad.

Dr. Meye r (I) a nd Dr. Parkman were the first to atte nuata the rube lla virus.

Dr. Ronald Goor Joins Staff of NIAID Lab

Dr. Ronald S. Goor has been ap­pointed a staff fellow at the Na­tional Institute of Allergy and In­fectious Diseases.

A biochemist, he will be work­ing in the Labo1·atory of Biology of Viruses.

Dr. Goor is a native of Wash­ington, D. C. He reeeived his Ph.D. degree from Harvard University in 1967.

Prior to joining NIAID, Dr. Goor had been on a postdoctoral fellowship at the National Insti­tute of Arthritis and Metabolic Diseases.

THE NIH REC(

Welcome Aboard! BEMT S Without Mi

Photos by Edward A.

"How do you pack a goldfish ·1" asks Julia Pritchard of the Bureau Administ1·ative Office.

This was only one of t he ques­tions without answers asked dur­ing the move of the Bureau of Health Professions Education and Manpower Training from the Ball­ston Center Tower Building Num­ber 1 in Arli11gton, Va. to the new wing of Building 31 on t he NIH reservation.

The move began the weekend of March 7. Many of the offices start­ed to pack early in the week and fin ished minutes before the moving crews descended on them late Fri­day afternoon.

Repol'ting for duty on Monday morning, BEMT employees found their offices piled high with fu rni­ture and boxes. However, with re­mar kable good humor a nd calm, under the circumstances, they r e­versed gears and managed to un­pack and carry on noi·mal business of the day.

Expecting a great deal of confu­sion, an after-hom·s visitor to the new wing was amazed at the re-

Dr. Leonard Fenninger, BEMT Director, check$ progren of the pocking.

RD, March 18, 1969

• urv,ves Move Beat

to • ss,ng a

Hubbard and Wayne Bard

• ma1·kable efficiency of the movers. The entire move is being accom­

plished by the NIH Transporta­tion Section with six moving vans and two 28-foot trailers. Each trailer carries approximately ten rooms of furniture.

In order to place the furnitw·e, as far as possible, in the r ight spot, blueprints are posted on each door.

Not only were swrveys made to determine the best route, btc~ the Transportation Section coordinat ed its activities with those of Com­munications, Space Management, Plant Engineering, and Housekcep­i11g Sootions to effect as smooth and painless a move as possible.

This is what is happening in Bldg. 31.

Moving vans are coming and go­ing. Strong men are heaving boxes, moving furniture and placing para­phenalia. The devoted distaff side is adding a homey touch-a knick­nack here, a vase there.

The last day of t he move will s u1·ely come. The sigh of rnl ief will be heard o'er the reser vation­BE:\1.T has arrived!

Reservation

James R. We lch (r), Transportation Se ction head, unfurls the American flag w ith the assistance of Eddie Craig .

Page 6

DR. MASUR (Continued from Page 1)

Care Administration. Dr. Masur was president of the

American Hospital Association in 1962, being the firsrt Government otlicial to hold this posit.

He also had the distinction of membership on the J oint Commis­sion on Accl·editation of Hospitals from 1954 to 1962 and was l'eap­pointed for the ninth time in De­cember 1968.

Because of Dr. Masur 's broad experience and recognized profess­ional ability in hospital adminis­tration and construction, he was frequently called upon to partici­pate in surveys and serve on ad­visory panels abroad as well as in th is country.

I n 1965 he was one of five Amer­ican physicians sent by t he PHS to study health services in the Soviet Union. He addressed the Tenth World Health Assembly in Lisbon in 1957.

The following year, at the re­quest of the U.S. Department of State, Dr. Masur pa1ticipated in a survey of hospital facil ities in Ber­lin. In 1961 he attended the Inter­national Symposium on Hospitals and Medical School Design held in Dundee, Scotland.

He participated in a study tour of hospitals in Belgium in 1962, and was among a select group at

A happy occosian far Or. Masur was the day in June 1959 when g ro und was broke n for construc tion o f the Surgical Wing that serves the NHI Cardiac Surge ry Bra nch and the NINDS Surgical Neurology Branch.

the Numeld Symposium, in 1963, which planned for a balanced teaching hospital to be established in Birmingham, England.

Dr. Masur had also served as Hospital Consultant, Federation of J ewish Philanthropies, New York City; Chief Medical Officer, U.S. Office of Vocational Rehabilitation; and Hospital Officer, U.S. Office of Civilian Defense.

He entered hospital administra­tion at the age of 28 as Assistant Director, Montefiore Hospital, in New York, wheu'<! he had completed a residency in internal medicine.

Born in Augusta, Ga., in 1908, Dr. Masur moved to New York City in his youth. He received his

March 18, 1969

Dr. Jack Masur, a Giant in Size, Gentle In Spirit-He Will Be Missed at NIH

Contributed by o Former Clinical Ce nter Staff Member

Dr. Jack Masur was a giant in size, and this helped reinforce an impression of forcefulness. Everything about him was big, even the nib of his fountain pen (he would have nothing to do with those ball­

point pens that wrote l;ines all of a size) .

When a note anived from him, the words were big. "NO!" a note might say concerning a proposed plan, or, in forwarding a compli­ment t hat he had received, con­cerning a matter in which an as­sociate had had a pa1t, "THANK YOU!"

For so large a man, his voice was gentle. It was deep and reso­nant, never stumbled, and was courteous. He was always con­

Children and th2 NIH Patients' W ei- cerned lest he offend a lady. In fore Fund were o lways c, concern of Dr. Masur. He re he receives proceeds raised by the c nnuol N IH Children ·s fa;, from (I to r) Lcu ise Hofliday, Richard Zipkin, a nd Douglas Kresh-over.

his speeches, he often t imes used a story about a Viennese actor who was offered a stage role which af­forded him the opportunity of kiss­ing the leading lady's hand.

The actor explained his accept-

Tributes to Dr. Jack Masur The following tri butes to Dr. Jack Masur were among the many

received at. NIH: Dr. Robe1t Q. Marston, N IH Director:

"Dr . Jack Ma.11ir 1cc1s 1.i great man in all u:ays, a.~ a frie?Ul, as a physicum, as a connselor, as an officer in the Pl-IS- to n<irne 011/y a fe1.c.

" JirJ,ile all of us who were n.~sol-irtled with him are sciddened /;y his llntimely death, it i.~ gratifying to know that hi.s .spirit lives on in the Clinical Center.

"For ns <Lt N IH, thnt ?·enuirlmble inRtitution is Dr. Ma,;ur' s trim memo1·icLl. Nuthiny could be more fi tting, becaw;e it symbolizes his dediwti.on to the henllh of <lll mnnlc-iml."

Dr. James A. Shannon, former NIH Director:

"My profesfli01uil aud prrsmml association u•ith nr. Jack Mcts1tr goes Imel.: more limn 20 yewrs-from the lime thu.t he wrt~ concerned with the pu:inni11g of the Clinical Center, throuyh his tenure rLs chief of the Pl-IS Bnrean of Medicnl Services mul his ?·eturn t o N IH ,is Director of the institution thnt he himself lmd de.signed.

"To 7mt it con~erNLlii>ely, his performance of duty fa ench of these ussiynments 1V((S ea·lnwrdinary. Howeve1·, it shonld be emphasized tlwt his wo,·k in the Washin!lton area was only a part of his cont1-ilmtion to lwspitcils e·verywhere.

"! luwe often henrcl him refer to hospitctfo as 'bettering lwu.~es.' B ecrw.~e of Dr. Jl£ck Mrum.1· and other dedicated persons, hospital.~ more clewrly de.~erve tlmt description toda.y than ever before."

D1·. William H. Stewart, PHS Surgeon Genera l: "Dr. Jnck Masur w<1s one of the ablest ho,;piu.tl admi11ist1·ators thcit

I hnve known. He 71lnyed a 1najor role in the development of the Clini­cal Center ns a uniq11.e resem·ch institution.

"The citt,-ilmte tlwt I liked rno.~t about lJr. Mrisio· was his iusistence that the 1Hitienl br give11 7>rimcf!ry considemtion, and I /,elieve thcil this a ttitude conl?-ilmted grecitly to the s1wcess of the NIH clinical r esearch proyram."

premedical training at University College, New York University, and was graduated in 1928. He re­ceived his medical degree from Cornel.l University Medical School in l!J32, and interned at Bellevue Hospital.

Dr. Masur was a Sandham Fel­low in Biology at NYU, and a Traveling Fellow in Intemal Med­icine and Biochemistry, Monte­fiore Hospital, New York City, to

Wilhelmina Gasthuis, Univers.ity of Amsterdam, Holland, in 1935.

A Diplomate of the American Board of P1·eve11tive Medicine and Public Health, he was also a F el­low of the American College of P hysicians, American College of Hospital Administrators, N ew York Academy of Medicine, Amer­ican Medical Association, Ameri­can Public Health Association, and the American College of Preven-

THE NIH RECORDrHI

ance of tr.,e small part by saying, "After all, one must begin some-I where.'' Dr. Masur liked the story; it was successful; yet, whenever T he included it in a speech, henur: would ask his secretary if she wasple sure no lady would be offended. som

Perhaps it was his courtesy ;men perhaps it was his expression of T gratit ude every time a subordinatehesi helped; perhaps it was simply theClin excellence of the Clinfoal Center-"Bli Dr. Masur developed a loyal andfall proud staff. ingt

The phrase "The House thatpati Jack Built"-referring to the Clin-and ical Center-meant more than say- lY. ing that he had p layed a majorgar, role in planning and construction.pitc It meant that it was Jack's House,for in which J ack's Family worked. the

Once, a Clinical Center official, D complaining t.o a per son in an-plin other NJH organization, said, "If wif, you do what you are planning, I'm ing

Following he r tour o l the Clinico i Cente r in April 1962, Empress Farah o f Iran tells Or. Masur (through her interpret er) that it wos the highlight o f her visit to the U. S.

going to take it to the top!" It was automatically understood that the "top" was Jack Masur .

the Ma,

F.

All members of the Family were entitled to consideration; all were subject to rules. When winter ap­proached, everyone would receive Dr. a memo reminding him that in the forr event of snow, he was essential. Sha

( Src GENTf,g 1;/.>\N'I', /'age 7) to the

t ive Medicine. ter' He had been a member of the

Advisory Committee of the Ke!- ne, logg Foundation and of t he Sloan of l nst it utc for Hospital Administra- in tiM. li

Dr. Masur received the PHS mo Distinguished Service Medal in Un I !)65, and the Founders Award of I the Associat.i on of Military Sur- an geons in 1968. ter

He leaves his wife, Barbara be! Forsch Masur; a son, Henry, 22, the who is a medical student at Cor- I nell University; three daughters, so Nancy, 24, of the home address; enc J ennie, 20, a sophomore at Mount be Holyoke College, a nd Co1·inne, 14, be of the home, a student at Cathe- l dral School in Washington. yie

A pictorial exhibit on events in oU Dr. Masur's life is being featured pe1 at the NIH Library in the Clinical me Center. The display will be there I for about 3 weeks. ne

:DJ'HE NIB RECORD

;~ GENTLE GIANT y; (Continued from Page 0)

er This meant not just doctors and cienurses; it included :personnel peo­asple and clerks. "I a m essential?"

someone would a.sk in astonish­y ;ment, and the answer was, yes. of T his, pal·adoxically, led to co­tehesiveness. A proud week for the 1eClinical Center came dur ing t he -''Blizzard of '66"-the worst snow-1clfall to hit the Metropolitan Wash-

ington area in 44 years-when 400 atpatients had to be taken care of­n-and were. y- Many employees who had re­orgarded themselves as nonessential n. pitched in and did essential tasks (e,for those still t rying to dig through

the drifts. d , Dr. Masur loved to receive com­n- p liments for h is House. A patient's If wife would write that she was go­ming to rename the Clinical Center

the "House of Hope," and D,·. Masur's eyes would go shiny.

He loved it; he would direct that each person w'l10 had had a hand in that patient's care be furnished a copy of the lette1·, together with an expression of his own grati­tude.

Yet, he would not capitalize on such a lette r. Tt could not be used in formal reports, and he would

ve Dr. Jack Masur, accompanied by he farmer N1H Director Dr. James A.

Shonnon escorts President Johnson in­to the Clinical Center for o tour of

- the research hospito l during the lat-ter's visit ta NIH July 21 , 1967.

he ~I- never allow phrases such as "one an of the best hospitals" to be used a- in reference to the Clinical Center.

It could be characterized as "a IS modern hospital, l ike others in the in Uni ted States." of H e refused to exploit patients in 1r- an effort to make t he Clinical Cen-

ter appear more impressive. He ra believed that a patient is part of '.2, the research team. ,r- Since the patient is contributing rs, so much, he should not be asked or :s; encouraged to allow his pictu re to nt be taken or his individual story to l4, be told. ,e- If the study on that patie11 t

yielded information that helped in others, it could be told in an ,m­ed ,1 ersonal scientific article or in a ~al med ical conference setting. ,re In vain, wl'iters for the public

nedia would protest t hat big stories

March 18, )969

NIH Scientists, Grantees Show Measles Virus Associated With Brain Disorder

Ors. David A. Fuccillo, John L. Sever, and Luix Horta Barbosa, all of the Perinatal Rcseorch Bronch, NINOS, e1tamine phatagrophs of fluorescent anti­body technique .

By Julian Morris

Isolation of the first common virus associated with a progressive, chronic nervous system disease iJ1 humans has been reported by NIH and NIH g,·ant-supported scientists.

are told in terms of li ttle people. Dr. Masur had a profound convic­tion that a )latient has a moral right to privacy.

He was a 1·omantic; he was emo­tional; he was a sentimentalist He appeared to value personal re­lationships abov!' all things, Among the short letters that streamed from h is office would be one thank­ing an 8-year-old for playing a piano piece for him while he was visiting in the parents' home.

He never hesitated to express his regard for a person in tones t hat showed he wanted everybody to know it. He was master of cere­monies at t he reception for Dr. James A. Shannon when t he lat­ter was retiring a.s NIH Director, and he made appropriate comments in introducing several dignitaries.

When he came to Mrs. Shannon, he said merely, "Alice, Alice, Alice" in that big, resonant voice. ~'rom anot.her, it might have been bathos; from Dr. Jack Masur, it was-well, you should h ave been there.

He treasured a cluster of books in which he had found thoughtful passages; he a)lparently read these 01· rcfel't'ed to them over and over. He found inspiration in a New Testament passage: the one in the Book of Saint John about the Pool of Bethesda.

He thought this story of the making whole of the halt and with­ered had particular relevance to the Clinical Center. The Biblical verses hung on his office wall and a re d isplayed in the Clinical Cen­ter lobby.

Dr. J ack Masur reached out to others, and touched many, for he was as big in spirit as he was in stature.

Their demonstration that ml'-as les virus is associated with a ra r e brain disorder, subacute sclerosing pan­encephalitis (SSPE), may help in determining whether-as is sus­pected- viruses cause mult iple sclerosis, 1:'a1·ki11s011's disease, and other more common neurological disorders.

Drs. Luiz Horta Barbosa, David A. Fuccillo, and John L. Sever, National Institute of Neurological Diseases and Stroke, and Dr. Wolf­gang Zeman of Indiana University Medical Center reported their iso­lation of measles virus from in­fected SSPE brain tissue in the journal Nrrture, March 8, l9G9.

Although virns had been sus­pected as the cause of SSPE for 35 years, it was not until 1965 that convincing evidence began to accumulate indicating measles vi­rus was involved.

Children with the disease were observed to have high levels of measles antibody in their blood and spinal fluid, sustained over several months.

Similarity Shown

Elect,·on microscopic examina­t ion of infected brain cells rev-ealed s tructures simila1· to those formed by measles virus.

l 11 d i re ct fluorescent-antibody tests using measles antisera show­ed specific intracellular vir al im­munofluoTescence in brain cells, fur ther implicating the measles virus.

Until the present st udy, free in­fectious virus had not b2en isolated from brain or other tissue speci­mens from t hese children.

It is not known why only one person i 11 a mi I lion ever suffers from SSPE, although neady every American has been exposed to measles before age 20.

However, at a recent press con-

Page 7

New 'Dry' Stand ls Open For Business in Bldg. 35

Employees of Buildings 36 and 37 ,vill be happy to know cf t he opening March 3 of a new dry st a nd. It is managed by Mrs. Catherine Reilly, and is located in Room 35B201, di ­rectly below the cafeteria.

A wide variety of items, ranging from candy, cookies, tobacco, newspapers, maga­zine6, and cards, a lready are available. Others will be added shortly.

ference, t he scientists offered two possible explanations :

One, t hat SSPE victims have a l'are defect in their immune sys­tems which allows the slow-devel­oping infection to occur . The other explanati-011 may be that a variant form of the measles virus causes SSPE.

But, according to Dr. Sever, if the agent resvonsible for SSPE does differ from the virus causing measles, no known laboratory tech­n'q11es have been able to reveal this.

SSPF. should not be confused with measles encephalitis, a more common but sLill rare complication of acute measles infection, occur-1,ing once in about every thousand cas.es.

Measles encephalitis, which de­velops within a few days of the viral infection, is believed by some researchers to be an associated al­lergic reaction not directly attrib­utable to the virus.

This theory may have to be re­evaluated in light of the present

Or. Barbosa studies a brain tissue cul­ture manolayer in a le ight on tube.

findings, accol'ding to Dr. Zeman. Attempts to isolate an infectious

agent from cultures of SSPE-in­fected brain cells had been unsuc­cessful until the NIH team mixed brain cell cultures with HeLa cell cultur es.

HeLa cells ate derived from cancerous human tissue and are used in viral studies because of their rapid growth and metabo­lism. The two cultures combin('d to form a s ingle one containing many

(See 8/lAIN DISORPF;R, Pan• 8)

Page 8

DDH Produces Films on Continuing Education, Surgical Procedures

Two new films, "University With­out Vlalls,'' and "Surgical Pro­cedures for Gingivoplas ty and Gin­givectomy," are now available to the dental profession.

They were produced by the Di­vision of Dental Health, Bureau of Health Professions Education and Manpower Training, and are ready for short-term l-0an.

The "University Without Walls,'' is a 12-minute, s-0und color movie (in bo·th 8 and 16 mm) in which the problem of continuing dental education is discussed.

Two methods of automated self­instl-uction are demonstrated.

'l'he one-hour motion picture on surgical procedures is a "first" in the field of dental education.

Viewers Answer Questions

Viewers actively participate by answering questions on the mate­rial presented. A response card and a summnry brochure are part of this education package.

'l'he film fh-st briefly reviews in­dications and contraindicaitions for the operation to augment diagnos­tic skills of the general practi­tioner.

A major part of this film on gingivoplasty and gingivectomy in­cludes measuring and marking periodor,tal pockets, estimating the correct line and angle of incision, considerations in the shaping and contouring of the gingiva, and postoperative treatment.

Inquiries on t he films should be addressed to: Continuing Educa­tion Branch, Division of Dental Health, Dental Health Center, USPHS, 14th Avenue and Lake Street, San Francisco, Calif. 94118.

DR. SEBRELL (Contima:d from Pa(Jo 1)

Two years later he was appoint­ed Director of Columbia's Institute of Nutrition Sciences, an interna­ti:ma.lly recognized institution for training professionals in public health nutrition for service in their native countries.

Dr. Sebrell is also an advisor on htcrnational public health nutri­tion problems. He serves as a con­sultant to WHO, FAO, and the U.N. Children's Fund.

He has been a member of the Food and Nutrition Board of the National Research Council since 195B. Dr. Sebrell is recognized par­t icularly for his work in efltablish­ing certain standards that are es­sential in the human diet.

During this coming summer he will lead a multinational team which will conduct a country-wide nutrition survey of the Dominican Republic. The survey will be spon­sored by Research Corporation.

March 18, 1969

Bureau of Health Professions Education and Manpower Training

New l ocation, Phone Numbers in Building 31

0 ffice of the Directm· Room Extension Dr. Leonard D. Fenninger 5C-02 64068

Director D r. Joseph A. Gallagher 5C-02 64046

Deput y Director Dr. Charles H . Boettner 5C-02 64111

Associate Director Richard W. Bunch 5C-11 61012

Executive Officer Harry C. Abernathy 5C-ll 61089

Assistant Executive Officer Lambert G. Longen 5C-l7 62112

Special Assistant, Office of Administrative Management

Harold F . Eisele 5B-63 64875 Chief, Special Projects Staff

Elizabeth Chase 5C-32 62127 Special Assistant

Joseph Preissig 5C-23 62573 Special Assistant for Program Planning a,nd Budgeting

Mel White 5B-62 66011 Acting Director, Office of Inforrnation

Margar et D. West 5C-27 62251 Director, Office of Program Planning and Evaluation

J oseph J . Cooney 5B-50 66281 Chief, Cont1·acts Staff

William Liggett 5R-5.5 66895 Chief, Data Systems Staff

J ohn W. Hambleton 5C-36 62414 Chief, Financial Management Staff

Edward J. Cunningham 5B-43 64661 Chief, General Services Staff

J ames W. Thomas 5C-35 62313 Chief, Management Planning and Ap1ffaisal Staff

J ohn H. O'Brien 5B-42 66154 Chief, Personnel Staff

Ge01·ge A. Harvey liR-[il 63683 Chief, Regulations and Legislative Reference Staff

Division H eads

Dr. Daniel Whiteside 3C-02 61071 Director, Division of Health Manpower and Educational Services

Jessie M. Scott 2C-39 61418 Director, Division of Nursing

Dr. Frank McKee 3B-03 66724 Director, Division of Physician Manpower

Dr. Charles H. Boettner 5C-02 6411 1 Acting Director, Division of Allied Health Manpower

Dr. Thomas Bowery 5B-03 65605 Director, Division of Research Resources Division of Dental Health will remain in its present location.

Dr. Sebre ll, former NIH Director (rJ, who receive d citation for his leoder­ship in public health nutrition from Dr. Coles, will soon conduct o nutri­tion survey of the Dominican Re­public.

BRAIN DISORDER (Co,rtinued from Pape 1)

giant cells. The supernatant fluid was found

t o contain an infectious agent which immunological tests proved to be measl';)s virus.

The scientists believe that the HeLa cells 1·elease suppressed ge­netic information in the infected brain cells, enabling t he devclop­men t of complete, infectious virus fr.om the latent, incomplete, non­infectious viral material in the cell.

Cell culture combinations are be­ing used in other studies in an ef-

THE NIH RECORD

The 'Old West' Switches From Flathead (Indian) To Egghead {Scientist )

In 150 years Hamilton, Mont. has gone from a populat ion of F lathead Indians to egghead sci­entists.

On a per capita basis, it seems that Hamilton may have more rec­ognized scientists than any other cit y in the North~vest. This is the "heady" observation one draws from glancing at World Who's Who in Science.

Hamilton, the ancestral home of the F lathead Indian tribe, lies deep in the Bitterroot Valley of western Monta,na and is now t he home of the National Institute of Allergy and Infectious Diseases' Rocky Mountain Laboratory.

The "Who's Who" just issued by t he A. N . Marquis Co., includes 30,000 scientists, 1 iving and dead.

In relation to population, the whole state of Montana should have only three scientists. However, in Hamilton alone five scientist s as­sociated with the RML are among those listed.

'l'hey a1·e Drs. J ohn J. Munoz, Glen M. Kohls, William L. Jelli­son, Richard A. Ormsbee, and Cor­nelius B. P hilip.

DR. FREDRICKSO N (Co»ti,mcd from Paoc 1)

Recently, Dr. Fredrickson and his colleagues intr oduced a new system for using plasma lipopro­tcin patterns to identify and class­ify excesses of blood cholesterol and other fats.

With it they have demonstrated sever al new syndromes not p1·evi­ously recognized as separate dis­eases.

Employing s i mp le, low-cost methods, this system is coming in­to wide clinical use as a basis for the diagnosis, treatment, and fol­lowup of patients with elevated blood lipids.

The system establishes the prev­alence of these diseases which are frequently associated with accel­erated development of atheroscle-rosis.

Dr. Fredrickson received h is B.S. and M.D. degrees at the University of Michigan. He did postgraduate work at Peter Bent Brigham Hos­pital, Massachusetts General Hos­pital, and Harvard Medical Schoot

He joined the NHI staff as a clinical associate in 1953. He was c-ertified by the American Board of Internal Medicine in 1957.

fort to find "hidden" viruses in hu­man cancer and ot!wr diseases.

The technique will doubtless be employed in future studies of chronic, degenerative neurological disorders of unknown origin.