July – August 2018ReseaRch Bulletin

Malcolm Whitman, Receives R01 supplement from nih/niaMs

Malcolm Whitman, PhD, professor of Developmental Biology, and Interim Dean for Research, received a Supplemental Award from NIH’s National Institute of Arthritis and Musculoskeletal and Skin Diseases for his R01 entitled, “Role of the First Secreted Tyrosine Kinase in Bone Development, Homeostasis,and Repair.”

Diseases associated with pathological changes of the extracellular matrix have a tremendous impact on the quality of life and well-being for all individuals. In the skeleton, these changes may include reduced bone density with age, osteoarthritis, and increased bone remodeling during tumor metastasis. The Whitman Lab has identified a new mechanism for the regulation of proteins that control bone and cartilage matrix homeostasis, with substantial implications for new therapeutic approaches to skeletal disease. These studies will define a novel mechanism for the regulation of the extracellular matrix function in bone, providing a new approach to the therapeutic modulation of skeletal development, homeostasis, and repair.

Yingzi Yang, Receives R01 from nih/national cancer institute

Yingzi Yang, PhD, professor of Developmental Biology, received an R01 Award from NIH’s National Cancer Institute entitled, “Cellular and Molecular Mechanism of Hippo Signaling in Suppressing Liver Tumor Formation.”

Recent studies have expanded the concept that inflammation is a critical component of tumor progression. Therefore, there is an urgent need to better understand cancer-immune

interactions, particularly under specific contexts of cells, tissues and deficient molecular pathways involved. Human hepatocellular carcinoma (HCC), a primary malignancy of the liver and the second-leading cause of cancer mortality worldwide is an example of inflammation-induced cancer.

The Hippo signaling pathway which the Yang Lab plays a critical role, has recently emerged as a major oncosuppressive pathway and play critical roles inhibiting hepatocyte proliferation, survival, and HCC formation. The goal of this study is to determine a previously unknown functional mechanism by which Hippo signaling in hepatocytes attenuates hepatocarcinogenesis by inhibiting macrophage infiltration and TAM differentiation. The Yang Lab has identified two secreted effectors of Hippo signaling in hepatocytes, each of which partially mediates Hippo effects in restricting inflammatory response and tumor growth.

Yang hypothesizes that a previously unknown function of Hippo signaling in hepatocytes is to regulate pro-tumor immune response by at least partially inhibiting Mcp1 and Jag1 expression. The knowledge gained from this project will establish a solid new foundation for further mechanistic investigation of hepatic Hippo signaling in inducing inflammation, tumor microenvironment remodeling, and provide new targets and strategies to treat HCC.

The Yang Lab includes the following postodoctoral research fellows: Drs. Qian Cong, Yuchen Liu, Emily Moore, Xiaohui Wang, Prem Yadav, and Miao Zhang. Additonal Lab members include: visiting postgraduate research fellow, Dr. Xiaolei Zhang; and visiting graduate students, Drs. Shuhao Feng, Bo Gao, and Taifeng Zhou; as well as summer intern Anna Li, and research assistant, Yaxing Zhou.

2 Research Bulletin • July – August 2018 • Harvard School of Dental Medicine

new Postdoctoral Fellows

Rocio Fuente Perez, Ms, PhD, joined the ionescu lab as a postdoctoral research fellow in the Department of Developmental Biology. Fuente Perez received a master’s degree in biomedicine

and molecular oncology from the University of Oviedo. She completed her PhD in biomedicine in Fernando Santos Laboratory in the Pediatric Research Group at the University of Oviedo, Spain, and Allan Bradley Laboratory in the Mouse Genomics Group at the Welcome Trust Sanger Institute, Cambridge, United Kingdom. Fuente Perez’s previous research involved the study of growth plate development in children with kidney disease using several animal models. In the Ionescu Lab, Fuente Perez will focus on the molecular mechanism that govern the articular cartilage hypertrophy and osteoarthritis evolution.

Kaho Ogawa, DDs, joined the nagai lab as a postdoctoral research fellow in the Department of Restorative Dentistry and Biomaterials sciences. Ogawa comes from Japan and received her dental degree from

Iwate Medical University. In the Nagai Lab, she is working on studying the comprehensive assessment of Japanese universal health coverage system, focussing on the reform of the dental insurance system. Ogawa is also working on the statistical analysis of the relationship between oral health and cognitive health.

hsDM/Forsyth chalk talksseptember 25, 2018

12-1pm @ The Forsyth InstituteVicki Rosen, PhD

Professor and Chair of Developmental Biology

October 19, 201812-1pm @ HSDM

Xiaozhe han, DDs, Msc, PhDAssociate Member of the Staff, Forsyth;

Lecturer in Oral Medicine, Infection, and Immunity

november 9, 201812-1pm @ The Forsyth Institute

satya Kota, PhDInstructor on Oral Medicine, Infection, and Immunity

December 14, 201812-1pm @ HSDM

Floyd Dewhirst, DDs, PhDSenior Member of the Staff, Forsyth;

Professor of Oral Medicine, Infection, and Immunity

hsDM Publications DeVelOPMental BiOlOgYGiddon D, Assael L. For preventive medicine to include oral health care, the dental profession, licensing agencies, payers, and the public must effect change. Preventive Medicine 2018;114:200-204.

Jiang L, Chen W, Geng Q, Du G, He P, Feng D, Qin T, Wei X.The cardiothoracic ratio: a neglected preoperative risk-stratified method for patients with rheumatic heart disease undergoing valve replacement surgery. European Journal of Cardio-Thoracic Surgery 2018; Jul 17.

Jiang Y, Feng D, Ma X, Fan S, Gao Y, Fu K, Wang Y, Sun J, Yao X, Liu C, Zhang H, Xu L, Liu A, Gonzalez FJ, Yang Y, Gao B, Huang M, Bi H. Pregnane X receptor regulates liver size and liver cell fate via yes-associated protein activation. Hepatology 2018; Jul 26.

Kim A, Gu D, Chandiramani R, Linjawi I, Deutsch I, Allareddy V, Masoud M. Accuracy and reliability of digital craniofacial measurements using a small-format, handheld 3D camera. Orthodontics and Craniofacial Research 2018; Jun 4.

Loder E, Weizenbaum E, Giddon D. Migraine pain location and measures of healthcare use and distress: An observational study. Pain Research Management 2018; Jun 4.

Volloch V, Rits S. Results of beta secretase-inhibitor clinical trials support amyloid precursor protein-independent generation of beta amyloid in sporadic Alzheimer’s disease. Medical Sciences (Basel) 2018; 6(2).

Research Bulletin • July – August 2018 • Harvard School of Dental Medicine 3

ORal MeDicine, inFectiOn anD iMMunitYBachour P, Sonis S. Predicting mucositis risk associated with cytotoxic cancer treatment regimens: rationale, complexity, and challenges. Current Opinion in Supportive and Palliative Care 2018;12(2):198-210.

Bajaj R, Courbebaisse M, Kroshinsky D, Thadhani I, Nigwekar S. Calciphylaxis in patients with normal renal function: A Case series and systematic review. Mayo Clinic Proc 2018; Jul 27.

Chapple I, Mealey B, Van Dyke T, Bartold P, Dommisch H, Eickholz P, Geisinger M, Genco R, Glogauer M, Goldstein M, Griffin T, Holmstrup P, Johnson G, Kapila Y, Lang N, Meyle J, Murakami S, Plemons J, Romito G, Shapira L, Tatakis D, Teughels W, Trombelli L, Walter C, Wimmer G, Xenoudi P, Yoshie H. Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus Report 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions. Journal of Periodontology 2018;89:S74-S84.

El Kholy K, Freire M, Chen T, Van Dyke T. Resolvin E1 promotes bone preservation under inflammatory conditions. Frontiers in Immunology 2018; 9:1300.

Hanna G, Kofman E, Shazib M, Woo SB, Reardon B, Treister N, Haddad R, Cutler C, Antin J, Van Allen E, Uppaluri R, Soiffer R. Integrated genomic characterization of oral carcinomas in post-hematopoietic stem cell transplantation survivors. Oral Oncology 2018; 81:1-9.

Ide N, Ye R, Courbebaisse M, Olauson H, Densmore M, Larsson T, Hanai J, Lanske B. In vivo evidence for an interplay of FGF23/Klotho/PTH axis on the phosphate handling in renal proximal tubules. American Journal of Physiology and Renal Physiology 2018; Jul 11.

Jepsen S, Caton J, Albandar J, Bissada N, Bouchard P, Cortellini P, Demirel K, de Sanctis M, Ercoli C, Fan J, Geurs N, Hughes F, Jin L, Kantarci A, Lalla E, Madianos P, Matthews D, McGuire M, Mills M, Preshaw P, Reynolds M, Sculean A, Susin C, West N, Yamazaki K. Consensus Report 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions. Journal of Periodontology 2018;89:S237-S248.

Lee C, Kim S. Effectiveness of a flipped classroom in learning periodontal diagnosis and treatment planning. Journal of Dental Education 2018; 82(6):614-620.

Mawardi H, Hashmi S, Elad S, Aljurf M, Treister N. Chronic graft-versus-host disease: current management paradigm and future perspectives. Oral Diseases 2018; Jul 9.

Shekar R, George B, Bohnen J, Villa A. A SIMPL application to assess oral medicine residents’ performance and level of autonomy. Oral Surgery Oral Medicine Oral Pathology Oral Radiology 2018; May 29.

Shukla A, Nyambose J, Vanucci R, Johnson L, Welch K, Lind E, Villa A. Evaluating the effectiveness of human papillomavirus educational intervention among oral health professionals. Journal of Cancer Education 2018; Jul 13.

Tsukamoto S, Løvendorf M, Park J, Salem K, Reagan M, Manier S, Zavidij O, Rahmat M, Huynh D, Takagi S, Kawano Y, Kokubun K, Thrue C, Nagano K, Petri A, Roccaro A, Capelletti M, Baron R, Kauppinen S, Ghobrial I. Inhibition of microRNA-138 enhances bone formation in multiple myeloma bone marrow niche. Leukemia 2018; Jun 20.

Villa A, Hanna G. Human papillomavirus and oropharyngeal cancer. Current Problems in Cancer 2018; Jun 27.

Villa A, Stoopler E, Napenas J. Employment type and career satisfaction among oral medicine specialists. Journal of Dental Education 2018; 82(6):630-635.

Viniegra A, Goldberg H, Çil Ç, Fine N, Sheikh Z, Galli M, Freire M, Wang Y, Van Dyke T, Glogauer M, Sima C. Resolving macrophages counter osteolysis by anabolic actions on bone cells. Journal of Dental Research 2018; Jul 1.

Yu Y, Wilk K, Waldon P, Intini G. In vivo identification of Bmp2-correlation networks during fracture healing by means of a limb-specific conditional inactivation of Bmp2.Bone 2018; Jul 23.

ORal anD MaXillOFacial suRgeRY Heffernan C, Calabrese C, Resnick C. Does mandibular distraction change the laryngoscopy grade in infants with Robin Sequence? Journal of Oral and Maxillofacial Surgery 2018; Jun 4.

Peacock Z, Krishnan D. Advances in imaging over 100 years: The impact on oral and maxillofacial surgery. Journal of Oral and Maxillofacial Surgery 2018; 76(7):1387-1399.

Zhou S, Glowacki J. Dehydroepiandrosterone and bone.Vitamins and Hormones 2018;108:251-271.

ORal health POlicY anD ePiDeMiOlOgYAbo-Sido N, Simon L, Tobey M. Rates of criminal legal system involvement among patients who are discharged against medical advice. Journal of General Internal Medicine 2018; Jun 29.

Hackley D, Mumena C, Gatarayiha A, Cancedda C, Barrow J. A case study optimizing human resources in Rwanda’s first dental school: Three innovative management tools. Journal of Dental Education 2018; 82(6):602-607.

Morgan J, Isyagi M, Ntaganira J, Gatarayiha A, Pagni S, Roomian T, Finkelman M, Steffensen J, Barrow J, Mumena C, Hackley D. Building oral health research infrastructure: The first national oral health survey of Rwanda. Global Health Action 2018;11(1):1477249.

RestORatiVe DentistRY anD BiOMateRials sciencesHwang H, Lee S, Park E, Yoon H. Assessment of the trueness and tissue surface adaptation of CAD-CAM maxillary denture bases manufactured using digital light processing. Journal of Prosthetic Dentistry 2018; Jul 10.

Multi-DePaRtMentalKihara H, Kim D, Nagai M, Nojiri T, Nagai S, Chen C, Lee C, Hatakeyama W, Kondo H, Da Silva J. Epithelial cell adhesion efficacy of a novel peptide identified by panning on a smooth titanium surface. International Journal of Oral Sciences 2018; 10(3):21.

Kressirer C, Chen T, Lake Harriman K, Frias-Lopez J, Dewhirst F, Tavares M, Tanner A. Functional profiles of coronal and dentin caries in children. Journal of Oral Microbiology 2018;10(1):1495976.

4 Research Bulletin • July – August 2018 • Harvard School of Dental Medicine

a publication of the Office of Research

188 Longwood Avenue Boston, MA 02115

www.hsdm.harvard.edu

Malcolm Whitman, PhD, Interim Dean for Research

Dawn M. DeCosta, Editor and Layout

Heather M. Denny, Editing

Lia Sgourakes, Editing

Francesca gori, named Program Director of the hsDM Forsyth Research academy

Francesca Gori, PhD, assistant professor of Oral Medicine, Infection and Immunity at HSDM, has been named Program Director for the

HSDM Forsyth Research Academy. The Research Academy is a three-year structured Doctor of Medical Sciences (DMSc-only), research-intensive degree in oral biology. Under the mentorship of world-renowned scientists, participants undertake an intensive research training experience in laboratories at HSDM or Forsyth. The goal of the program is to train academic researchers in oral and craniofacial biology and skeletogenesis in the best possible scientific environment, and thus provide superior research leadership to institutions and countries around the globe. The Oversight Committee includes; Francesca Gori, PhD (Director); Yingzi Yang, PhD; Thomas Van Dyke, DDS, PhD; and, Alpdogan Kantarci, DDS, MSc, PhD.

Brian swann, awarded Dean’s community service award for Wampanoag tribe Work

Brian J. Swann, DDS, recently promoted assistant professor of Oral Health Policy and Epidemiology, was awarded a 2018 Dean's Community Service Award for his work with the Wampanoag Tribe Oral Health Relief Effort. Since 2013, Swann has led efforts to bring sustainable, comprehensive, family-centered oral health care to the underserved native population on Martha's Vineyard. He has built lasting relationships within the Tribe, as well as mentored numerous students who have

traveled with him to Martha’s Vineyard to work with the population and learn first-hand the importance of public health dentistry, and culturally-sensitive care. Swann graduated from the University of California San Francisco, School of Dentistry. After a 30-year career in public health and private practice, he realized he would make a greater impact by focusing on community dentistry and public health policy. This decision led him to Boston as the first Joseph L. Henry Fellow in Minority Health Policy. He earned certificates in Minority Health Policy from Harvard Medical School, and Oral Health Policy and Epidemiology from HSDM.

hiroe Ohyama completes hMs academy Medical education Fellowship

Hiroe Ohyama, DDS, MMSc, PhD, DMD, assistant professor of Restorative Dentistry and Biomaterials Sciences, successfully completed the HMS Academy Medical Education Fellowship. Ohyama published two papers during the Fellowship period. The HMS Academy Medical Education Fellowship provides educators with dedicated time to develop the expertise and skills needed to advance academic careers in medical education research. The Director of the HMS Academy Medical Education Fellowship, David Hirsh, MD, is photographed with Ohyama.