McCormick

Robert R. McCormick School of Engineering and Applied ScienceNorthwestern University

Department of Chemical and Biological Engineering

Seventh Annual

Richard S. H. Mah Lectures on Modeling and Computation in Chemical and Biological Engineering

Presented by

Francis J. Doyle IIIAssociate Dean for Research

College of Engineering

University of California, Santa Barbara

McCormick

Northwestern Engineering

The Department of Chemical and Biological Engineering

in the Robert R. McCormick School of Engineering and

Applied Science at Northwestern University

cordially invites you to the

Seventh Annual Richard S. H. Mah Lectures on Modeling and Computation in Chemical and Biological Engineering

Presented by

Francis J. Doyle III Associate Dean for Research

College of Engineering

University of California, Santa Barbara

The Role of Process Systems Engineering in the Quest for the Artificial Pancreas (general audience)Wednesday, November 9, 2011Lecture 4:30 p.m.Pancoe Auditorium, Room 1101 Arthur and Gladys Pancoe –NSUHS Life Sciences Pavilion 2200 Campus Drive, Evanston, IllinoisReception to follow in the Einstein Bros. Bagels meeting area

Parking is available after 4 p.m. in the parking lot east of the Pancoe Life Sciences Pavilion

Robust Timekeeping in Circadian Clock Networks(Chemical and Biological Engineering Department audience) Thursday, November 10, 2011Lecture 9 a.m.Technological Institute, LR52145 Sheridan Road, Evanston, Illinois

www.chem-biol-eng.northwestern.edu

The Role of Process Systems Engineering in the Quest for the Artificial PancreasWednesday, November 9

Lecture 4:30 p.m.; reception to follow

Type 1 diabetes mellitus (T1DM) is a chronic autoimmune disease affecting about

3 million Americans. Associated health-care costs are estimated at $15 billion a

year. Current treatment requires multiple daily insulin injections or continuous sub-

cutaneous insulin infusion delivered via a pump. Both necessitate frequent blood

glucose measurements.

More than 30 years ago the idea of an artificial endocrine pancreas for T1DM

patients was envisioned. The closed-loop concept consisted of an insulin syringe,

a blood glucose analyzer, and a transmitter. A number of theoretical research

studies were performed with numerical simulations to demonstrate the relevance

of advanced control design to the artificial pancreas, with delivery algorithms

ranging from simple PID to H-infinity to model predictive control. The development

of continuous glucose sensing and of hardware and algorithms to communicate

with and control insulin pumps has brought the vision of closed-loop control of

blood glucose close to a reality.

In the last 10 years our research group has been working with medical doctors

on clinical investigations of control algorithms for the artificial pancreas. This talk

will cover the difficulties of controlling physiological variables, the challenges of

regulatory approval of devices, and the clinical testing of algorithms for feedback

control of the artificial pancreas based on model predictive control.

Robust Timekeeping in Circadian Clock NetworksThursday, November 10

Lecture 9 a.m.

Circadian timekeeping by intracellular molecular clocks is found throughout

nature. The clockworks are driven by autoregulatory feedback loops that

lead to oscillating levels of components whose maxima are in fixed-phase

relationships with one another. Circadian clocks are ideal systems for study-

ing relations between noise and its propagation in complex networks and

robustness. Tools from systems theory are introduced that elucidate design

principles in these complex architectures through the analysis of robust

and fragile regions of the network. Analysis of the performance properties

of circadian gene networks reveals the design principles that emerge from

these richly layered and hierarchical regulatory circuits.

This talk will highlight some recent results that analyze robustness properties

at the tissue level, where intercellular coupling appears to be responsible for

the generation of robust rhythms in the face of noise and other uncertainties.

In the absence of intercellular signaling, the individual (cellular) oscillators

lose these properties of robust performance. Finally, abstractions of the bio-

physical models will be used to generate theorems on the interplay of local

and global driving forces and the impact on the rate of synchronization.

Francis J. Doyle III

Francis J. Doyle III is the associate dean for research in the College of Engineering

at the University of California, Santa Barbara, and director of the Army Institute for

Collaborative Biotechnologies. He holds the Duncan and Suzanne Mellichamp Chair in

Process Control in the university's chemical engineer-

ing department and appointments in electrical engi-

neering and biomolecular science and engineering.

Doyle's research group works in systems biology,

bringing systems-theoretic approaches to the model-

ing and analysis of complex biophysical systems rang-

ing from gene regulatory networks to protein signaling

networks to intercellular coupling. The group has a

particular interest in periodic phenomena in nature,

such as circadian timekeeping, and brings novel

analysis and simulation methods to the treatment of

stochastic coupled oscillators. It works closely with

medical partners for clinical trials and with biolo-

gists for experimental studies. In its large diabetes research effort, it has designed an

artificial pancreas for subjects with type 1 diabetes and works to identify novel drug

targets for insulin resistance underlying type 2 diabetes. Larger collaborative efforts

include modeling tauopathies in Alzheimer’s disease and biomarker discovery for post-

traumatic stress disorder.

Doyle received a BSE degree from Princeton University (1985), CPGS from Cambridge

University (1986), and PhD from California Institute of Technology (1991), all in chemi-

cal engineering. He has held faculty appointments at Purdue University and the

University of Delaware and visiting positions at DuPont and Weyerhaeuser and at

Stuttgart University. His research awards include the 2005 Computing in Chemical

Engineering Award from the American Institute of Chemical Engineers for his innova-

tive work in systems biology, the NSF National Young Investigator, the Office of Naval

Research Young Investigator, and the Humboldt Research Fellowship. He is a fellow of

multiple professional societies was editor in chief of the IEEE Transactions on Control

Systems Technology from 2004 to 2009.

Richard S. H. Mah Lecturers

2005 James Wei, Princeton University

2006 John H. Seinfeld, California Institute of Technology

2007 Bernhard Ø. Palsson, University of California, San Diego

2008 Glenn H. Fredrickson, University of California, Santa Barbara

2009 Matthew Neurock, University of Virginia

2010 Athanassios Z. Panagiotopoulos, Princeton University

Richard S. H. Mah

Richard S. H. Mah was a leader in the movement to incorporate digital computing

methods and their applications into chemical engineering practice and education.

Born in China, Mah received a BSc from England’s

University of Birmingham and a PhD from Imperial

College in London, both in chemical engineering.

After a two-year postdoctoral appointment at the

University of Minnesota, he spent five years each

with Union Carbide Corporation and the Exxon Math

and Systems Company. From 1972, when he joined

Northwestern, until 1995, Mah dedicated his life to

chemical engineering education and research. He

authored many papers in the technical literature as

well as the influential monograph Chemical Process

Structure and Information Flows (1993). Mah held

leadership positions in the Computing and Systems

Technology division of the American Institute of

Chemical Engineers (AIChE). He was a founding member and later president of

CACHE, a nonprofit corporation dedicated to furthering the use of computer aids for

chemical engineering. Among his many professional accolades were the Youden Prize

of the American Society for Quality Control (1986), the AIChE Computing in Chemical

Engineering Award (1981), and the Ernest Thiele Award of the Chicago Section of

AIChE (1990). He became a fellow of the AIChE in 1985. His last formal scholarly

accomplishment was a DSc in chemical engineering from the University of London

Imperial College of Science and Technology in 1993.

The Richard S. H. Mah Lectures on Modeling and Computation in Chemical and

Biological Engineering have been established through the generosity of the Mah

family to honor the memory of Richard S. H. Mah and his contributions to Northwestern

University, its Department of Chemical and Biological Engineering, and the profession

of chemical engineering. In particular, the lectures are meant to honor Mah’s role as a

champion of introducing digital computing into modern chemical engineering. Each

year a recognized leader in the field is invited to address topics that will cover diverse

applications within the broad area of modeling and computation in chemical and

biological engineering and will also appeal to individuals working in a wide range of

disciplines.