MAGELLAN is a high-throughput, parallel organic synthesiser designed for resin-basedsolid phase synthesis. It automates the creation of diverse compound libraries and issuitable for both pharmaceutical and agrochemical research.

FEATURES:

Organic Synthesiser

High-throughput parallel synthesiser

Modular, scaleable system with full computernetworking

96-position, removable Reaction Block

Reagent and Reaction Blocks all bar coded forsecurity of operation

Separate Heater-Agitators for off-line incubations

Resin-based, solid phase chemistry

Advanced liquid handling technology

Dual-function vacuum system for collection ofwaste or cleaved product

Reliable and robust hardware systems

Windows software for easy integration with hostcomputer systems

96-channel resin washing system

Flexible aliquoting of cleaved product

Magellan

TM

HOOK & TUCKERzenyx

HighThroughput Parallel SynthesisMAGELLAN is a high-throughput parallelorganic synthesiser designed to automatethe production of large numbers ofcompounds using resin-based, solid phasechemistry. MAGELLAN automates thefollowing processes:

Addition of reagents & solvents Heating and agitation of reactions Washing of resinsCleavage and collection of compoundsDistribution of compounds prior to HTS

Maximum Productivity MAGELLAN incorporates a number ofunique features designed to maximise theefficiency of organic synthesis including:

Removeable 96-position Reaction Block4-channel Solvent Delivery ProbeIntegral Heater-AgitatorDedicated Reagent Addition Probe8-way Solvent Selector Valve96-channel Filtration ManifoldPC controlled, off-line Heater-Agitators

Robust and ReliableA key consideration in the design ofMAGELLAN was to use practical, wellproven technology throughout. This hashelped to ensure maximum reliability inoperation as well as ease of maintenanceby both user and service engineer alike.Some examples of this approach includethe use of:

Robust liquid handling systemsSimple Reaction VesselsEasily replaceable tubing and filtersChemically resistant materials

Powerful Integrated Software MAGELLAN’s Windows software controlsboth the instrument and all chemicalprocesses. A Synthesis Task List gives theuser the means to control all synthetic stepsand allows highly complex chemistries to beset up. It also provides the interface to thelaboratory’s own computer systems.

Productivity is enhanced further bynetworked controlling software which co-ordinates the operation of any number ofMAGELLAN synthesisers and Heater-Agitators. This ensures that all units worktogether for maximum efficiency.

Automated Reagent & Solvent AdditionReaction Vessels containing pre-dispensedresin are initially loaded into a 96 positionReaction Block. This is identified by its barcode and placed in MAGELLAN’s IntegralHeater-Agitator. Reagents are then addedas specified in the Synthesis Task List.

On and Off-Line Heating & AgitationThe Reaction Block is agitated and, ifrequired, heated. If reaction times are longit can be removed and placed in an off-lineHeater-Agitator to maximise the use of thesynthesiser for more intensive pipetting andwashing steps.

Each off-line Heater-Agitator is also linkedto a PC. When a Reaction Block is placedon an external unit it is first identified by itsbar code. MAGELLAN’s network softwarethen resumes control of the reaction. Whenthe reaction is complete it can then placedback on the MAGELLAN for washing.

High-Speed Resin WashingDuring a wash cycle the 96-channel filtrationmanifold aspirates excess reagents to oneof two separate waste bottles. A solvent isthen dispensed into the reaction tubes torinse the Filtration Needles and the resin.A number of wash cycles using differentsolvents can be performed before the nextset of reagents is added.

Cleavage and CollectionWhen the synthesis is complete, cleavagereagent is added to the Reaction Vessels. A 96-position Collection Block is loaded intothe Collection Bay and released compoundsare then transferred by the FiltrationManifold into Collection Tubes.

Automated Compound DistributionAfter compound collection, the CollectionBlock can be removed and the compoundsdried down. The Compound CollectionBlock can also be placed on theMAGELLAN bed and the contentsdistributed directly into bar codedmicroplates and vials. All identifiers arestored in a database and can be used laterto control downstream processes.

A separate automated CompoundDistribution system is also available. This isparticularly suitable for the higherthroughput laboratory generating largenumbers of compound libraries.

Magellan

Heater-AgitatorReaction vessels: 96 Glass tubes (15ml) Resin Capacity: 200 mgsHeating: Up to 150°C Heating Rate: 2°C per minShaking: Orbital @ 100-600 rpm

Fluid SystemTubing: PTFE/PCTFE Probes: Nickel alloy

Physical SpecificationsDimensions: Weight: 150Kg Size: 1150W x 720D x 710H (mm)

HOOK & TUCKER ZENYX Brochure BRC0006 (Issue 4) March 2000

Technical Information

Filtration Probes

Integral Heater-Agitator

MAGELLAN

TM

HOOK & TUCKERzenyx

Vulcan WayNew AddingtonCroydonCR0 9UGUnited Kingdom

Telephone: +44 (0) 1689 843345Fax: +44 (0) 1689 841792E-mail: sales@htz.bizWeb site: http://www.htz.biz