METABOLIC PROFILE AND OSTEOPOROSIS IN POSTMENOPAUSAL WOMEN

First author: Valentina Cojocaru

Coauthor: Mara-Maria Bercea

Coordinator: Associate Professor Ionela Maria Paşcanu

22 millions women and5,5 millions men in EU€ 37 bilion 1,180,000 quality-adjusted life years lost during 2010

INTRODUCTION

“Osteoporosis in the European Union: medical management, epidemiology and economic burden”, E. Hernlund, A. Svedbom, M. Ivergård , Arch Osteoporos (2013) 8:136

OBJECTIVE

MATERIAL AND METHOD

Retrospective case-control study

296 postmenopausal women from Endocrinology Department between 2009-2015

196 with osteoporosis 100 without osteoporosis

Were not included patients with antihyperlipidemic agents treatment, thyroid disorders, hypercortisolism

Body mass index between 18,5 and 35 kg/m² Cut off for enumerated blood parameters and

contingency tables accordingly

RESULTS

For total cholesterol level > 200 mg/dl as a risk factor for osteoporosisOddsRatio 4,91p< 0,001

RESULTS

For HDL-cholesterol level > 45 mg/dl as a risk factor for osteoporosisOR 2,83p< 0,05

RESULTS

For LDL-cholesterol level > 150 mg/dl as a risk factor for osteoporosisOR 3,03p< 0,05

RESULTS

For serum levels of triglycerides > 130 mg/dlOR 0,76p< 0,05

RESULTS

For serum levels of magnesium > 2 mg/dlOR 0,24p< 0,05

RESULT

For uric acid serum levels > 6mg/dl OR 0,69p= 0,30

RESULTS

For iron serum levels > 100 µg/dlOR 1,45p=0,31

RESULTSFor phosphate serum levels > 3mg/dlOR 1,55p= 0,22

DISSCUSIONS

Yamagughi et al.: high LDL-cholesterol is associated with low bone mineral density (BMD) at radial site

Cui LH et al.: The serum levels of total cholesterol and LDL-cholesterol were inversely associated with pre- and post-menopausal women

“Plasma lipids and osteoporosis in postmenopausal women.” Yamaguchi T1, Sugimoto T, Yano S et al., Endocr J. 2002 Apr;49(2):211-7

“Association between bone mineral densities and serum lipid profiles of pre- and post-menopausal rural women in South Korea.” Cui LH1, Shin MH, Chung EK et al., Osteoporos Int. 2005 Dec;16(12):1975-81

Buizert PJ et al.:  “The lipid profile that is favorable in the prevention of CVD (high levels of HDL-c and low TC/HDL-c ratio) is unfavorable for BMD”

Adami S et al. : High levels of total cholesterol, triglycerides, LDL-cholesterol, triglycerides are positively associated to BMD

“Lipid levels: a link between cardiovascular disease and osteoporosis?”. Buizert PJ1, van Schoor NM, Lips P et al., J Bone Miner Res. 2009 Jun;24(6):1103-9.

“Relationship between lipids and bone mass in 2 cohorts of healthy women and men.” Adami S1, Braga V, Zamboni M e al., Calcified Tissue International 2004 Feb;74(2):136-42.

Atherogenic lipid profile is proosteoporotic

Atherogenic lipid profile is antiosteoporotic

DISSCUSIONS

The experimental studies show:

“Bone density and hyperlipidemia: the T-lymphocyte connection.” Graham LS1, Tintut Y, Parhami F et al., J Bone Miner Res. 2010 Nov;25(11):2460-9“The Roles of Lipid Oxidation Products and Receptor Activator of Nuclear Factor-κB Signaling in Atherosclerotic Calcification.” Linda Demer, Yin TintutMay;, Circulation Research.2011; 108: 1482-1493.

DISCUSSIONS

Stendig-Lindberg G et al.: in their clinical trial, increasing the intake of magnesium in postmenopausal osteoporotic women increased the BMD

“Trabecular bone density in a two year controlled trial of peroral magnesium in osteoporosis.” Stendig-Lindberg G1, Tepper R, Leichter I., Magnes Res 1993 Jun;6(2):155-63.

Zheng et al.: Iron defficit is a risk factor for osteoporosis

Danoux CB et al.: “inorganic phosphate has a positive effect on the expression of osteogenic markers”

“Low serum levels of zinc, copper, and iron as risk factors for osteoporosis: a meta-analysis”. Zheng J, Mao X, Ling J et al., Biol Trace Elem Res 2014 Jul;160(1):15-23.

“Elucidating the individual effects of calcium and phosphate ions on hMSCs by using composite materials.”, Danoux CB, Bassett DC2, Othman Z et al., Acta Biomater 2015 Apr 15;17:1-15

Magnesium role Iron and Phosphate

CONCLUSIONS

CONCLUSIONS

A serum level of total cholesterol > 200 mg/dl, a HDL-cholesterol level > 45 mg/dl, a LDL-cholesterol level > 150 mg/dl are risk factors for osteoporosis

A serum level of triglycerides > 130 mg/dl and a magnesium serum level >2 mg/dl are protective factors for osteoporosis

Iron, uric acid and phosphate serum level are indifferent factors

BIBLIOGRAPHY “Osteoporosis in the European Union: medical management, epidemiology and economic burden”

E. Hernlund, A. Svedbom, M. Ivergård et al., 2013. “Plasma lipids and osteoporosis in postmenopausal women.” Yamaguchi T1, Sugimoto T, Yano S et

al., Endocr J. 2002 Apr;49(2):211-7 “Association between bone mineral densities and serum lipid profiles of pre- and post-menopausal

rural women in South Korea.” Cui LH1, Shin MH, Chung EK et al., Osteoporos Int. 2005 Dec;16(12):1975-81

“Lipid levels: a link between cardiovascular disease and osteoporosis?”. Buizert PJ1, van Schoor NM, Lips P et al., J Bone Miner Res. 2009 Jun;24(6):1103-9.

“Relationship between lipids and bone mass in 2 cohorts of healthy women and men.” Adami S1, Braga V, Zamboni M e al., Calcified Tissue International 2004 Feb;74(2):136-42.

“Bone density and hyperlipidemia: the T-lymphocyte connection.” Graham LS1, Tintut Y, Parhami F et al., J Bone Miner Res. 2010 Nov;25(11):2460-9.

“The Roles of Lipid Oxidation Products and Receptor Activator of Nuclear Factor-κB Signaling in Atherosclerotic Calcification.” Linda Demer, Yin TintutMay;, Circulation Research.2011; 108: 1482-1493

“Oxysterols regulate differentiation of mesenchymal stem cells: pro-bone and anti-fat.” Kha HT1, Basseri B, Shouhed D et al., J Bone Miner Res. 2004 May;19(5):830-40

“Trabecular bone density in a two year controlled trial of peroral magnesium in osteoporosis.” Stendig-Lindberg G1, Tepper R, Leichter I., Magnes Res 1993 Jun;6(2):155-63.

“Elucidating the individual effects of calcium and phosphate ions on hMSCs by using composite materials.”, Danoux CB, Bassett DC2, Othman Z et al., Acta Biomater 2015 Apr 15;17:1-15

“Low serum levels of zinc, copper, and iron as risk factors for osteoporosis: a meta-analysis”. Zheng J, Mao X, Ling J et al., Biol Trace Elem Res 2014 Jul;160(1):15-23.

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