Upload
others
View
5
Download
0
Embed Size (px)
Citation preview
M. Babar Imran, PINUM
M. Babar Imran, PINUM
An Art to attempt MCQs!
Dr M Babar Imran
MBBS, MSc, MS, PhD, FRCP
Director
PINUM Cancer Hospital
Faisalabad, Pakistan
For ABNM Candidates
M. Babar Imran, PINUM
Examination
What is an examination?
A test to see how good somebody is at
something
meant to determine suitability and to test
the required knowledge for the given job /title
M. Babar Imran, PINUM
Exam, Lecture and Black Bitter Coffee
One Common Feeling
.
M. Babar Imran, PINUM
Exam, Lecture and Black Bitter Coffee
One Common Feeling
It is always pleasure when one finishes
M. Babar Imran, PINUM
MCQs
Know the subject
Know how to attempt
M. Babar Imran, PINUM
When I will finish my talk
Understanding Instructions
Understanding the Stem
Selection Correct Answer
If you really don’t know the answer
Solved Questions with explanations
M. Babar Imran, PINUM
Which of the following is used for
skeletal scintigraphy?
a-MIBI
b-DTPA
c-MDP
d-HMPAO
Stem
Options
*
* Distractors
* Distractor
Anatomy of MCQ
M. Babar Imran, PINUM
Stem
requires analysis of a problem
requires application of principles
requires evaluation of alternatives
to combine several concepts or ideas
to test higher order thinking
M. Babar Imran, PINUM
Stem
What, Why, How statement ?
Incomplete statement !
Calculation !
Which one correct / incorrect
Interpretation of images
M. Babar Imran, PINUM
Thoroughly understand the exam pattern. Know all the
sections of the exam
Understand yourself i.e. know your strengths and
weaknesses.
Strength lies where you had been able to answer the
question in half of the allocated time (eg 30 sec) and
weakness where you had to spend more than
allocated time
Before Exam
M. Babar Imran, PINUM
Instructions Read Carefully
Instructions
Any error in understanding the instructions is fatal
Questions
Common errors occur when students fail to accurately
or thoroughly read the question. Understand what is
being emphasized / what is being asked before
starting to read the answer
M. Babar Imran, PINUM
Read the Stem
What is being asked?
If one or more options are correct
If assertion is on Negative or Positive
Underline the important words
M. Babar Imran, PINUM
Which one of the following statements about
Radioactive Iodine is TRUE?
a.Radioactive Iodine-131 is used for only treatment
purpose in benign and malignant thyroid diseases.
b.Radioactive Iodine-125 is used for imaging and
treatment purpose in benign and malignant thyroid
diseases
c. Radioactive Iodine-131 is used for imaging and
treatment purpose in benign and malignant thyroid
diseases.
d. Radioactive Iodine-125 is used for treatment
purpose in benign and malignant thyroid diseases.
M. Babar Imran, PINUM
Which one of the following statements about
Radioactive Iodine is TRUE?
a.Radioactive Iodine-131 is used for only treatment
purpose in benign and malignant thyroid diseases.
b.Radioactive Iodine-125 is used for imaging and
treatment purpose in benign and malignant thyroid
diseases
c. Radioactive Iodine-131 is used for imaging and
treatment purpose in benign and malignant thyroid
diseases.
d. Radioactive Iodine-125 is used for treatment
purpose in benign and malignant thyroid diseases.
M. Babar Imran, PINUM
Which one of the following statements about
Radioactive Iodine is False?
a. Radioactive Iodine-131 is used for treatment
purpose in benign and malignant thyroid
diseases.
b. Radioactive Iodine-125 is used for imaging and
treatment purpose in benign and malignant
thyroid diseases
c. Radioactive Iodine-123 is used for imaging of
benign and malignant thyroid diseases.
d. None of the above
M. Babar Imran, PINUM
Which one of the following statements about
Radioactive Iodine is False?
a. Radioactive Iodine-131 is used for treatment
purpose in benign and malignant thyroid
diseases.
b. Radioactive Iodine-125 is used for imaging and
treatment purpose in benign and malignant
thyroid diseases
c. Radioactive Iodine-123 is used for imaging of
benign and malignant thyroid diseases.
d. None of the above correct
M. Babar Imran, PINUM
If Stem long---
If Stem is long, carefully read the last
sentence/last part, it may include the
main target
M. Babar Imran, PINUM
A 60 yr old woman, known case of spinal stenosis and
hypertension, presented with atypical chest pain. Her
physical mobility is limited to slow pace 200 meters
walk only. She is referred for adenosine stress MPS.
Her BP= 130/70 mm Hg and pulse is 70 b/m. Her
baseline ECG is without any significant abnormality.
Because she is capable of performing some exercise,
administering adenosine infusion in combination with
low level exercise is recommended . As compared with
adenosine infusion alone, what should be expected
when combining adenosine infusion with low level
exercise?
M. Babar Imran, PINUM
A 60 yr old woman, known case of spinal stenosis and hypertension,
presented with atypical chest pain. Her physical mobility is limited to slow
pace 200 meters walk only. She is referred for adenosine stress MPS. Her
BP= 130/70 mm Hg and pulse is 70 b/m. Her baseline ECG is without any
significant abnormality. Because she is capable of performing some exercise,
administering adenosine infusion in combination with low level exercise is
recommended . As compared with adenosine infusion alone, what should
be expected when combining adenosine infusion with low level
exercise?
a. Relatively Less adenosine related adverse effects
b. To avoid artifacts in patients with LBBB
c. Higher radiopharmaceutical activity in spleen
d. Long delay for data acquisition is needed after stress
M. Babar Imran, PINUM
Starting with the answer (1)
Think if you can answer without looking at options
MDP, HEDP
HMDP, HDP
NaF
M. Babar Imran, PINUM
A 40 year old male underwent 201Tl stress redistribution study for
evaluation of chest pain. How do you interpret this study?
Norm, Isch
Inf. Artfct
1. Reversible perfusion defect
involving apex
2. Reverse Redistribution involving
apex
3. Motion artifact during SPECT
acquisition
4. Abnormal Tracer uptake in RV
free wall.
M. Babar Imran, PINUM
1. Reversible perfusion defect
involving apex
2. Reverse Redistribution involving
apex
3. Motion artifact during SPECT
acquisition
4. Abnormal Tracer uptake in RV
free wall.
A 40 year old male underwent 201Tl stress redistribution study for
evaluation of chest pain. How do you interpret this study?
M. Babar Imran, PINUM
A 40 year old male underwent 201Tl stress redistribution study for
evaluation of chest pain. How do you interpret this study?
M. Babar Imran, PINUM
A 40 year old male underwent 201Tl stress redistribution study for
evaluation of chest pain. How do you interpret this study?
M. Babar Imran, PINUM
Eliminate the answers which you know are wrong
Starting with the answer (2)
M. Babar Imran, PINUM
M. Babar Imran, PINUM
M. Babar Imran, PINUM
M. Babar Imran, PINUM
M. Babar Imran, PINUM
M. Babar Imran, PINUM
Use True and False method for negatively worded
questions.
Which one of the following statements is not a common
finding on a conventional bone scan in a patient with
renal osteodystrophy?
a. Decreased uptake in the calvaria
Starting with the answer (3)
M. Babar Imran, PINUM
Use True and False method for negatively worded
questions.
Which one of the following statements is not a common
finding on a conventional bone scan in a patient with
renal osteodystrophy?
a. Decreased uptake in the calvaria is not a common
finding on bone scan in renal osteodystrophy
Starting with the answer (3)
M. Babar Imran, PINUM
Use True and False method for negatively worded
questions.
Which one of the following statements is not a common
finding on a conventional bone scan in a patient with
renal osteodystrophy?
a. Decreased uptake in the calvaria T
Starting with the answer (3)
M. Babar Imran, PINUM
Use True and False method for negatively worded
questions.
Which one of the following statements is not a common
finding on a conventional bone scan in a patient with
renal osteodystrophy?
a. Decreased uptake in the calvaria T
b. High-bone to soft tissue uptake ratio
Starting with the answer (3)
M. Babar Imran, PINUM
Use True and False method for negatively worded
questions.
Which one of the following statements is not a common
finding on a conventional bone scan in a patient with
renal osteodystrophy?
a. Decreased uptake in the calvaria T
b. High-bone to soft tissue uptake ratio is not a common
finding on bone scan in renal osteodystrophy
Starting with the answer (3)
M. Babar Imran, PINUM
Use True and False method for negatively worded
questions.
Which one of the following statements is not a common
finding on a conventional bone scan in a patient with
renal osteodystrophy?
a. Decreased uptake in the calvaria T
b. High-bone to soft tissue uptake ratio F
Starting with the answer (3)
M. Babar Imran, PINUM
Use True and False method for negatively worded
questions.
Which one of the following statements is not a common
finding on a conventional bone scan in a patient with
renal osteodystrophy?
a. Decreased uptake in the calvaria T
b. High-bone to soft tissue uptake ratio F
c. Minimal or no evidence of urinary activity
Starting with the answer (3)
M. Babar Imran, PINUM
Use True and False method for negatively worded
questions.
Which one of the following statements is not a common
finding on a conventional bone scan in a patient with
renal osteodystrophy?
a. Decreased uptake in the calvaria T
b. High-bone to soft tissue uptake ratio F
c. Minimal or no evidence of urinary activity is not a
common finding on bone scan in renal osteodystrophy
Starting with the answer (3)
M. Babar Imran, PINUM
Use True and False method for negatively worded
questions.
Which one of the following statements is not a common
finding on a conventional bone scan in a patient with
renal osteodystrophy?
a. Decreased uptake in the calvaria T
b. High-bone to soft tissue uptake ratio F
c. Minimal or no evidence of urinary activity F
Starting with the answer (3)
M. Babar Imran, PINUM
Use True and False method for negatively worded
questions.
Which one of the following statements is not a common
finding on a conventional bone scan in a patient with
renal osteodystrophy?
a. Decreased uptake in the calvaria T
b. High-bone to soft tissue uptake ratio F
c. Minimal or no evidence of urinary activity F
d. Increased uptake in the axial skeleton
Starting with the answer (3)
M. Babar Imran, PINUM
Use True and False method for negatively worded
questions.
Which one of the following statements is not a common
finding on a conventional bone scan in a patient with
renal osteodystrophy?
a. Decreased uptake in the calvaria T
b. High-bone to soft tissue uptake ratio F
c. Minimal or no evidence of urinary activity F
d. Increased uptake in the axial skeleton is not a common
finding on bone scan in renal osteodystrophy
Starting with the answer (3)
M. Babar Imran, PINUM
Use True and False method for negatively worded
questions.
Which one of the following statements is not a common
finding on a conventional bone scan in a patient with
renal osteodystrophy?
a. Decreased uptake in the calvaria T
b. High-bone to soft tissue uptake ratio F
c. Minimal or no evidence of urinary activity F
d. Increased uptake in the ax ial skeleton F
Starting with the answer (3)
M. Babar Imran, PINUM
Generally a positive choice is more likely to be true
than a negative choice
Usually a correct answer is with maximum information
Even if you are unfamiliar with the question, use
common sense and a good guess to respond
When guessing ask why it is right, does it make a
sense
Starting with the answer (4)
M. Babar Imran, PINUM
Research indicate that your first selected answer is
correct. Changing an answer should be under good
reasons
While dealing with a question, if your logic differs with
your knowledge, go for your knowledge.
Starting with the answer (4)
M. Babar Imran, PINUM
Do not stop reading all of options merely because you
are 100% sure about the correct choice else you will fail
to understand the tricks
All of the above
None of the above
2/4 Correct
2/4 incorrrect
Starting with the answer (4)
M. Babar Imran, PINUM
Notice words
“Always”, “Every”, “All”
Less likely correct than
“Some”, “many”, “few”
these give more room for exceptions
Starting with the answer (5)
M. Babar Imran, PINUM
Indicate which statement about regional cerebral blood
flow SPECT is false
a. It is useful in the differential diagnosis of dementia
b. It provides very specific pattern for each type of
dementia
c. It is useful for localization of the epileptogenic focus
before surgical
d. treatment of refractory epilepsy
e. Images reflect the regional cerebral blood flow at the
time of injection
M. Babar Imran, PINUM
Indicate which statement about regional cerebral blood
flow SPECT is false
a. It is useful in the differential diagnosis of dementia
b. It provides very specific pattern for each type of
dementia
c. It is useful for localization of the epileptogenic focus
before surgical
d. treatment of refractory epilepsy
e. Images reflect the regional cerebral blood flow at the
time of injection
M. Babar Imran, PINUM
Difficult Question (unseen info)
Eliminate
True / False test to each option
Grammatically not fitting
Absolute words “Always”, “All”, “every”
All /None options
For “number” answers, consider the middle one
Starting with the answer (6)
M. Babar Imran, PINUM
Two similar options, choose the best one
Two opposite options, one of them might be correct
Remember you looking for the best answer (not only
correct answer)
Totally Correct Least Correct
Difficult Question (unseen info)
Starting with the answer (6)
M. Babar Imran, PINUM
Try to attempt maximum questions (No Negative
Scores). Never leave a question un-answered.
M. Babar Imran, PINUM
Guessing
If there is no penalty…
Use hints from those question you know the answer for
those you don’t
While guessing once selected don’t change the answer,
usually your first answer is correct unless you mis-read
the question
Only change if you are sure about the correction
Option “C” -----
M. Babar Imran, PINUM
Fix response or response C
FEBNM, Solved Paper
Research has
shown that C
more frequently
correct than other
options
Guessing
M. Babar Imran, PINUM
Guessing
If there is no penalty…
Use hints from those question you know the answer for
those you don’t
While guessing once selected don’t change the answer,
usually your first answer is correct unless you mis-read
the question
Only change if you are sure about the correction
Option “C” has more than 25% chance being correct
M. Babar Imran, PINUM
Optimize the art of speed------
Old remains gold or at least like gold. Try to solve past
years paper to understand the exam format and to
build speed, correctness (if available)
M. Babar Imran, PINUM
Time Management
Do not stick to one question only
Try to keep time for review at the end – you could have
mis-read some questions
It is never a good idea to leave the hall earlier, unless
you are sure you have attempted all the questions
correctly.
At the end, left out questions may be tried with “Guess”
M. Babar Imran, PINUM
If you have studied sufficiently
and have good knowledge only
then these tips can help you to
gain reasonable scores
M. Babar Imran, PINUM
If you have studied sufficiently
and have good knowledge only
then these tips can help you to
gain reasonable scores
M. Babar Imran, PINUM
Spillage in hot lab and notification to radiation
safety officer
Major Spillage in hot lab
needs notification to RSO
M. Babar Imran, PINUM
After access restriction, which of the following
spillage in hot lab requires immediate notification
to radiation safety officer
a. I-123 8 mCi
b. Tl-201 90 mCi
c. Tc-99m MDP 110 mCi
d. Tc-99m MIBI 50 mCi
Major Spillage in hot lab
needs notification to RSO
M. Babar Imran, PINUM
After access restriction, which of the following
spillage in hot lab requires immediate notification
to radiation safety officer
a. I-123 8 mCi
b. Tl-201 90 mCi
c. Tc-99m MDP 110 mCi
d. Tc-99m MIBI 50 mCi Major Spillage in hot lab needs
notification to RSO
Spillage of more than 10 mCi of
I-123 or more than 100 mCi of
Tl-201/Tc99m NUREG 1556 Volum 9
M. Babar Imran, PINUM
Which of the following factors is essential in the
calculation of standardized uptake value (SUV)?
a. Time activity curve
b. Serum insulin level
c. Injected dose
d. Arterial radioactivity concentration
M. Babar Imran, PINUM
Which of the following factors is essential in the
calculation of standardized uptake value (SUV)?
a. Time activity curve
b. Serum insulin level
c. Injected dose
d. Arterial radioactivity concentration
M. Babar Imran, PINUM
In a crystal scintillation detector the size or amplitude of the
electrical pulse is generally proportional to the:
a. Activity
b. Gamma photon energy
c. Number of gamma photons
d. Number of electrons
M. Babar Imran, PINUM
If a low-energy collimator is (incorrectly) used with a high-
energy radionuclide the results would be:
a. A reduced camera sensitivity (counting efficiency)
b. A blurred image
c. A reduced field of view
d. Increased image detail
M. Babar Imran, PINUM
A collimator designed for use with radionuclides with relatively
low photon energies, such as technetium, has relatively thin
septa between the holes. High energy photons will produce
significant septal penetration which results in a blurring of the
image and reduced image detail.
M. Babar Imran, PINUM
In Nuclear Medicine departments chemical impurity of Alumina
in the Mo-99/Tc-99m generator elute is evaluated through
which of the following test:
a. Thin-layer chromatography
b. HPLC
c. Colorimetric qualitative spot test
d. Paper chromatography
M. Babar Imran, PINUM
In Nuclear Medicine departments chemical impurity of Alumina
in the Mo-99/Tc-99m generator elute is evaluated through
which of the following test:
a. Thin-layer chromatography
b. HPLC
c. Colorimetric qualitative spot test
d. Paper chromatography
The
quantified
M. Babar Imran, PINUM
Nuclear binding energies are usually expressed in units of:
a. keV
b. Watts
c. Joules
d. Newtons
M. Babar Imran, PINUM
Nuclear binding energy
is the minimum energy that would be required to
disassemble the nucleus of an atom into its
component parts. These component parts
are neutrons and protons, which are collectively
called nucleons.
Nuclear binding energy = Δmc2
The most commonly used unit is the MeV.
1 electron volt = 1eV = 1.6 x 10-19 joules
1 MeV = 106 eV; 1 GeV = 109 eV; 1 TeV = 1012 eV
M. Babar Imran, PINUM
Which combination is false?
a. Bremsstrahlung – electromagnetic radiation
b. Orbital electron capture – alpha decay
c. Isomer transition – gamma decay
d. Positron – annihilation radiation
M. Babar Imran, PINUM
One curie is equal to
a. 3.7 X 1010 dps
b. 3.7 X 1012 dpm
c. 3.7 X 107 dps
d. 2.2 X 109 dpm
Curie is a unit of radioactivity = 3.7 ×1010 disintegrations per second.
It is quantity of radioactive substance that emits one curie of activity.
"a curie of any radioactive element disintegrates at the same rate as 1
gram of natural radium”
1MBq = 2.7 uCi
M. Babar Imran, PINUM
Mode of decay by electron
capture occurs in all except:
a. Cr 51
b. Co 57
c. Ga 67
d. I 124
Iodine-124 is a positron
emitter with a half-life of
4.2 days and appropriate
chemical properties.
Measurements made
under realistic conditions
on several different PET
scanners have shown that
satisfactory imaging and
quantitation can be
achieved.
M. Babar Imran, PINUM
Stochastic effects. Effects that
occur by chance and which may
occur without a threshold level
of dose, whose probability is
proportional to the dose and
whose severity is independent
of the dose.
Stochastic effects in a mammal :
a. Cancer
b. Cataract
c. Radiation sickness
d. Sterility
M. Babar Imran, PINUM
Which of the following is not a PET radio-
pharmaceutical for imaging of neuroendocrine
tumors
a. 68 Ga-DOTANOC
b. 18 F-Fluorodopa
c. 177 Lu-DOTATATE
d. 18 F-FDG
M. Babar Imran, PINUM
Which of the following is not a PET radio-
pharmaceutical for imaging of neuroendocrine
tumors
a. 68 Ga-DOTANOC
b. 18 F-Fluorodopa
c. 177 Lu-DOTATATE
d. 18 F-FDG
M. Babar Imran, PINUM
A 60-year-old female with a history of gastroesophageal reflux,
attended the hospital complaining of chest pain at rest. Her
ECG and echocardiography were normal. She underwent MPI
which revealed reversible perfusion defects in the apex and
the inferior wall; LVEF was 59%. The expected perfusion scan
finding is:
a. Scan within normal limits
b. Moderate defect in the LAD territory
c. Large defect in the LAD territory
d. Large defect in the RCA territory
M. Babar Imran, PINUM
M. Babar Imran, PINUM
M. Babar Imran, PINUM
The given ECG shows
a. First degree AV Block
b. Right Bundle Branch Block
c. Left Bundle Branch Block
d. Interventricular Conduction
M. Babar Imran, PINUM
M. Babar Imran, PINUM
Which is useful for the evaluation of myocardial
sympathetic innervation?
a. I-123 BMIPP
b. I-123 MIBG
c. Tc-99m MIBI
d. Tl-201
M. Babar Imran, PINUM
MIBG is analog of norepinephrine (NE)
MIBG diffuses into the synaptic cleft
Taken up into pre-synaptic sympathetic
terminals via the NE transporter-1
(NET1) (energy dependent )
MIBG is not metabolized
MIBG & ITS MECHANISM OF ACTION
123I-MIBG imaging depicts integrity of re-uptake function, thus
the integrity and health of cardiac sympathetic innervation.
M. Babar Imran, PINUM
MIBG is not metabolized
It accumulates in the presynaptic
terminal.
123I-MIBG imaging depicts function
of the uptake-1 process, and thus
the integrity and health of cardiac
sympathetic innervation.
M. Babar Imran, PINUM
• Scintigraphic assessment of sympathetic
innervation of the myocardium in patients with
New York Heart Association [NYHA] class II or
class III HF and left ventricular ejection fraction
[LVEF] < 35%
• Help identify patients with lower one and two-
year mortality risks, as indicated by an [HMR]
ratio >1.6
Indications of Cardiac 123I-MIBG Imaging
M. Babar Imran, PINUM
M. Babar Imran, PINUM
Given the myocardial perfusion scan (MPS) of a 50-year-
old female (see below) with a TID of 1.1 which of the
following statements is true for the image below:
a. Normal MPI
b. Balanced ischemia
c. Transient ischemic dilatation
d. Suspected triple-vessel disease
TID : 1.1
M. Babar Imran, PINUM
Transient ischemic dilation (TID)
Stress-induced apparent increase in the size of the left
ventricle visualized by MPS
TID ratio is calculated dividing stress by rest LV
volumes; this is usually done on the non-gated images
defining the endocardial limits of the LV but also can
be done on the gated, end-diastolic images
M. Babar Imran, PINUM
• Transient ischemic dilation (TID) of the left ventricle (LV) is a
marker for severe and extensive CAD, which has been shown to
be of prognostic value.
• Although TID is usually higher in patients with LAD ischemia or
multivessel disease (MVD), it can also be found in patients with
LVH or diabetes.
• However, TID in the absence of evident perfusion abnormalities
should always raise the question of balanced myocardial ischemia
in the first place, which is more common in MVD.
M. Babar Imran, PINUM
A 47 year old female presented with progressive exertional dyspnea
for the last 3 months. There is no H/O angina. Adenosine stress Tc
99m MIBI gated cardiac scan is performed. LV EDV is 138 and 140
ml during rest and stress study. What is the most likely diagnosis
M. Babar Imran, PINUM
A 47 year old female presented with progressive exertional dyspnea
for the last 3 months. There is no H/O angina. Adenosine stress Tc
99m MIBI gated cardiac scan is performed. LV EDV is 138 and 140
ml during rest and stress study. What is the most likely diagnosis
1. LV infarct leading to dilated LV
2. Ischemic Heart Disease
3. Non Ischemic Cardiomyopathy
4. Infarct with peri infarct ischemia
Uniform perfusion with dilated LV and symptoms of LV
Failure strongly suggestive of dilated cardiomyopathy of
non ischemic origin
M. Babar Imran, PINUM
Which of the following examination is appropriate for the
early diagnosis of Alzheimer’s dementia?
a. Brain MRI
b. Brain 18F-FDG PET
c. Brain amyloid plaque imaging PET
d. CSF tau protein analysis
M. Babar Imran, PINUM
The characteristic features of Alzheimer’s disease (AD)
are the appearance of extracellular amyloid-beta (Aβ)
plaques and neurofibrillary tangles in the intracellular
environment, neuronal death and the loss of synapses, all
of which contribute to cognitive decline in a progressive
manner.
M. Babar Imran, PINUM
In Alzheimer’s disease, regional blood flow is decreased
except in the:
a. Temporal cortex
b. Posterior cingulate gyrus
c. Precuneus
d. Cerebellum
M. Babar Imran, PINUM
rCBF is an indirect measure for brain functional activity. Reduction in activity of
neurons or number of neurons leads to reduced rCBF
In AD there is decrease in flow (at single photon emission computed tomography) or
metabolism (at positron emission tomography [PET]) in the temporoparietal regions
M. Babar Imran, PINUM
Single Photon Emission Tomography
• The most widely used tracer is 99mTcHMPAO.
• Neuroreceptor studies using 123I-ioflupane(IFP)-CIT
(DAT-scan) which allows visualization of the
degeneration of the nigrostriatal dopaminergic neurons
• A 123IIBZM-SPECT shows the integrity of the
postsynaptic dopamine receptor.
M. Babar Imran, PINUM
Brain perfusion SPECT shows increase in CBF in the
following states except in:
a. Epileptic foci
b. Reperfusion after ischemia
c. Parkinson’s disease
d. Encephalitis
M. Babar Imran, PINUM
Which one of the following is normally used to explore the
cerebral vasodilatory flow reserve by means of CBF SPECT
a. Captopril
b. Acetazolamide
c. Dobutamine
d. Furosemide
M. Babar Imran, PINUM
An 80-year-old woman with recent onset of fever and
headache without any previous medical problems had CT,
MRI and SPECT scans performed. What is the possible
diagnosis?
a. Seizure
b. Herpes simplex encephalitis
c. Glioblastoma multiforme
d. Cerebral infarction
M. Babar Imran, PINUM
A 45-year-old female with diffuse large B-cell lymphoma
received 6 courses of R-CHOP therapy. F-18 FDG PET
images before and after treatment are shown. Which of the
following statement is the most likely interpretation of the F-
18 FDG uptake indicated by arrows in post therapy image?
a. Relapse of malignant lymphoma
b. Supraclavicular Lymph nodes
metastasis
c. Activation of brown adipose tissue
d. Neurolymphomatosis
M. Babar Imran, PINUM
Brown Fat
One of two types of adipose tissue (white and brown)
Contains smaller fat vacuoles, higher number of mitochondria, more capillaries than white fat
Richly innervated by sympathetic nerves (b1, b2, b3)
Uncoupling protein-1 (UCP-1, thermogenin) in inner mitochondrial membrane uncouples oxidative phosphorylation producing heat energy (non-shivering thermogenesis) with ATP provided by glycolysis
Present in newborns (5% body mass) and hibernating animals; most disappear in adulthood (not in mice)
Contribution to evolutionary success of mammals Cannon B et al. Physiol Rev 2004 (Sweden)
M. Babar Imran, PINUM
Kaposi’s Sarcoma is
1. Ga 67 negative and Tl 201 positive
2. Ga 67 positive and Tl 201 positive
3. Ga 67 negative and Tl 201 negative
4. Ga 67 positive and Tl 201 negative
Sensitivity of Tl-Ga combination
reduces in the presence of
opportunistic infections
M. Babar Imran, PINUM
Metastatic medullary thyroid carcinoma can
be localized with all except
a. 123I-MIBG
b. 131I-anti AFP antibodies
c. 18F-FDG
d. 111In-octreotide
Imaging Medullary Thyroid Carcinoma . J Clin Endocrinol Metab. 2007; 92: 4185-4190 Occult Medullary Carcinoma. HORMONES 2012, 11(2):210-214
AFP related with Liver
testis and ovarian tumor
/ congenital abnormalities
M. Babar Imran, PINUM
Bilaterally increased renal visualization on MDP
bone scanning can be found in the following
conditions except
a) Renal metastases
b) Hypercalcaemia
c) Recent chemotherpy
d) Renal vein thrombosis
M. Babar Imran, PINUM
Bilaterally increased renal visualization on MDP
bone scanning can be found in the following
conditions except
a) Renal metastases
b) Hypercalcaemia
c) Recent chemotherpy
d) Renal vein thrombosis
Hyperparathyroidism,
hypercalcaemia, iron
overload, cirrhosis and
sickle cell disease. Post
chemotherapy (cisplatin)
M. Babar Imran, PINUM
Bilaterally increased renal visualization on MDP
bone scanning can be found in the following
conditions except
a) Renal metastases
b) Hypercalcaemia
c) Recent chemotherpy
d) Renal vein thrombosis
Conventional NM agents,
uptake is always less in
tumour tissue
However, it is known not to
correlate with any specific
malignancy or the presence
of metastasis World J Nuc Med2005;4:104–7
M. Babar Imran, PINUM
Which of the following statements is true?
a. The mechanism of uptake of Tc-99m IDA is by Kupffer cell
extraction
b. Tc-99m mebrofenin has better hepatic extraction than Tc-
99m HIDA
c. The chemical structure of IDA radiopharmaceuticals is
similar to the diphosphonates
d. With hepatic insufficiency, the alternate elimination route
for IDA radiopharmaceuticals is via the bowel
M. Babar Imran, PINUM
Physiologic functions of the liver can be evaluated
1. 99mTc-Labeled IDA Derivatives used to evaluate the
functional status of the hepatocytes and the patency of the
biliary duct
2. Lipophilic compounds(99mTc-Sulfur Colloid) labeled with
radionuclides for RE system (Kupffer cells)
Hepatobiliary radiopharmaceuticals
M. Babar Imran, PINUM
A Two-month-old baby girl presented with jaundice since
birth with frequent vomiting and pale stools. Her bilirubin
level was 4.6 mg/dl. A Tc-99m DISIDA scan was done. What
is your most probable diagnosis?
a. Choledochal cyst
b. Biliary obstruction
c. Acute cholecystitis
d. Delayed biliary to bowel transit
M. Babar Imran, PINUM
High-grade common bile duct obstruction
Usually prompt liver uptake & function
No secretion of the radiotracer into biliary ducts.
Delayed images, even up to 24 h, often show only a
persistent hepatogram.
M. Babar Imran, PINUM
True statement regarding cholescintigraphy is
a.Chronic cholecystitis may cause non-visualization of
gallbladder even at 60 minutes
a.The common bile duct is usually seen starting at 60 min
b.Transit from the biliary ducts to small intestine normally
occurs in less than 5 minutes
c. In the arterial blood flow phase normally liver is seen
before the spleen and kidneys
M. Babar Imran, PINUM
True statement regarding cholescintigraphy is
a.Chronic cholecystitis may cause non-visualization of
gallbladder even at 60 minutes
a.The common bile duct is usually seen starting at 60 min
b.Transit from the biliary ducts to small intestine normally
occurs in less than 5 minutes
c. In the arterial blood flow phase normally liver is seen
before the spleen and kidneys
M. Babar Imran, PINUM
The gall bladder is usually not visualized on hepatobiliary
imaging in the following cases except:
a.acute cholecystitis
b.chronic cholecystitis
c. congenital biliary atresia
d.severe hyperbilirubinemia
M. Babar Imran, PINUM
In Meckel's diverticulum study; which statement is not correct
a. Tc-99m SC is used as radiopharmaceutical agent
b. The diagnostic sensitivity/PPV is high in children
c. The ectopic gastric mucosa is identified
d. Sequential views are obtained
PPV
Sensitivity
M. Babar Imran, PINUM
It is indicated primarily for overt mid or lower
gastrointestinal bleeding, specifically when an upper
gastrointestinal bleed has been excluded
Labeled RBCs & Tc-99m SC
Colloids can be used for acute bleeding only. RBCs for
intermittent as well
Diagnostic Criteria
1. The appearance of activity outside the expected anatomic
blood pool structures,
2. Change in the intensity of activity on consecutive images,
3. Movement of activity in a pattern consistent with bowel.
Gastrointestinal bleeding scintigraphy
M. Babar Imran, PINUM
Advantages of RBC scintigraphy
1. 10-fold greater sensitivity for detection of slow bleeding
rates or chronic bleeding
2. The ability to examine the entire lower GI tract
simultaneously and continuously over an extended period
of time (60 to 90 minutes)
3. The ability for repeat imaging up to 24 hours.
GI Bleed Scintigraphy Vs Angiography
M. Babar Imran, PINUM
A 2-year-old girl presents with lower GI bleeding episodes and anemia. A
Meckel’s scan is performed. A focus of ectopic tracer uptake is identified.
Which scinitigraphic findings would suggest that this focus represents a
Meckel’s diverticulum?
a. The focus appears simultaneously with the normal uptake in the gastric
mucosa and gradually fades away
b. The focus appears simultaneously with the normal uptake in the gastric
mucosa and intensifies during the study
c. The focus first appears 10 minutes post tracer injection and persists
throughout the remainder of the study
d. The focus first appears at an early stage in the right upper abdominal
quadrant, fades away and reappears towards the end of the study.
M. Babar Imran, PINUM
Which of the following is true regarding Tc-99m sulfur colloid
for the detection of GI bleed?
a. It has higher sensitivity than angiography
b. It is best for upper GI bleed
c. It is good for detecting intermittent bleeds
d. It requires labelling of RBCs
M. Babar Imran, PINUM
Exam
Subject
Practice Technique
Know
Succ
ess
M. Babar Imran, PINUM
Thank you very much for being with me
.