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www.ebmt.org #EBMT16 EBMT database 2016: transplants by disease category NRM (%) by period according to the intensity of the conditioning regimen Allo-SCT 18-50 yo NRM (%) by period 0 20000 40000 60000 80000 100000 120000 140000 139249 Multiple Myeloma Lymphoma Acute Leukemia Solid Tumor Chronic Leukemia MDS & MPN Bone Marrow Failure Inherited Disorder Hemoglobinopathy Autoimmune Disease Histiocytic Disorder 0% 5% 10% 15% 20% 25% 30% 35% 100d NRM 6 m NRM 12 m NRM 1994-1998 1999-2003 2004-2008 2009-2013 0% 5% 10% 15% 20% 25% 100d 6 m 12 m 1999-2003 2004-2008 2009-2013 0% 5% 10% 15% 20% 25% 100d 6 m 12 m 1999-2003 2004-2008 2009-2013 RIC MAC 0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100% 2000 2001 2002 2003 2004 2205 2006 2007 2008 2009 2010 2011 2012 2013 BEAM CBV Thiotepa TBI Conditioning regimens for lymphomas in the ASCT setting Transplant activity for lymphoma EBMT 2001-2012 0 20 40 60 80 100 120 140 160 180 200 0 200 400 600 800 1000 1200 1400 1600 1800 2000 auto allo Absolute numbers 2012 % increase 2001 -> 2011 CLL HL TCL DLCL FL MCL DLCL HL MCL TCL FL CLL Total lymphoma transplants 2012 (w/o CLL): allo 1427; auto 6177 -100 -50 0 50 100 150 0% 50% 100% 2000 2002 2004 2006 2008 2010 2012 BEAM CBV Thiotepa TBI 0% 50% 100% 2000 2002 2004 2006 2008 2010 2012 BEAM CBV Thiotepa TBI DLBCL 0% 50% 100% 2000 2002 2004 2006 2008 2010 2012 BEAM CBV Thiotepa TBI FL 0% 50% 100% 2000 2002 2004 2006 2008 2010 2012 BEAM CBV Thiotepa TBI MCL HL HL+DBBCL+FL+MCL 0 50 100 150 200 250 300 350 400 450 TCL FL CLL HL DLCL MCL Members and staff: Peter Dreger (Chair), Stephen Robinson (Secretary), Olivier Hermine, Silvia Montoto, Norbert Schmitz, Harry Schouten, Anna Sureda, Alina Tanase, Ariane Boumendil (Statistician), Hervé Finel (Study Coordinator) General activity Lymphoma Working Party

Lymphoma Working Party - EBMT. EBMT2016_Pos… · #EBMT16 EBMT database 2016: transplants by disease category NRM (%) by period according to the intensity of the conditioning regimen

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Page 1: Lymphoma Working Party - EBMT. EBMT2016_Pos… · #EBMT16 EBMT database 2016: transplants by disease category NRM (%) by period according to the intensity of the conditioning regimen

www.ebmt.org #EBMT16

EBMT database 2016: transplants by disease category

NRM (%) by period according to the intensity of the

conditioning regimen

Allo-SCT 18-50 yo – NRM (%) by period

0

20000

40000

60000

80000

100000

120000

140000

139249

Multiple Myeloma Lymphoma Acute Leukemia Solid Tumor

Chronic Leukemia MDS & MPN Bone Marrow Failure Inherited Disorder

Hemoglobinopathy Autoimmune Disease Histiocytic Disorder

0%

5%

10%

15%

20%

25%

30%

35%

100d NRM 6 m NRM 12 m NRM

1994-1998 1999-2003 2004-2008 2009-2013

0%

5%

10%

15%

20%

25%

100d 6 m 12 m

1999-2003 2004-2008 2009-2013

0%

5%

10%

15%

20%

25%

100d 6 m 12 m

1999-2003 2004-2008 2009-2013

RIC MAC

0%

10%

20%

30%

40%

50%

60%

70%

80%

90%

100%

2000 2001 2002 2003 2004 2205 2006 2007 2008 2009 2010 2011 2012 2013

BEAM CBV Thiotepa TBI

Conditioning regimens for lymphomas in the ASCT setting

Transplant activity for lymphoma EBMT 2001-2012

0

20

40

60

80

100

120

140

160

180

200

0

200

400

600

800

1000

1200

1400

1600

1800

2000

auto

allo

Absolute numbers 2012 % increase 2001 -> 2011

CLL HL TCL DLCL FL MCL

DLCL HL MCL TCL FL CLL

Total lymphoma transplants 2012 (w/o CLL): allo 1427; auto 6177

-100

-50

0

50

100

150

0%

50%

100%

2000 2002 2004 2006 2008 2010 2012

BEAM CBV Thiotepa TBI

0%

50%

100%

2000 2002 2004 2006 2008 2010 2012

BEAM CBV Thiotepa TBI

DLBCL

0%

50%

100%

2000 2002 2004 2006 2008 2010 2012

BEAM CBV Thiotepa TBI

FL

0%

50%

100%

2000 2002 2004 2006 2008 2010 2012

BEAM CBV Thiotepa TBI

MCL

HL HL+DBBCL+FL+MCL

0

50

100

150

200

250

300

350

400

450

TCL FL CLL HL DLCL MCL

Members and staff: Peter Dreger (Chair), Stephen Robinson (Secretary), Olivier

Hermine, Silvia Montoto, Norbert Schmitz, Harry Schouten, Anna Sureda, Alina

Tanase, Ariane Boumendil (Statistician), Hervé Finel (Study Coordinator)

General activity

Lymphoma Working Party