Lymphoid System VIBS 443/602 OBJECTIVES PURPOSE OF THE IMMUNE SYSTEM CELLULAR BASIS OF IMMUNITY
EFFECTORS OF RESPONSE INDUCTION OF THE RESPONSE ONTOGENY FUNCTIONS OF THE IMMUNE SYSTEM
PROTECTION AGAINST FOREIGN INVADERS INTO BODY PRODUCE / PROTECT GERM FREE ENVIRONMENT OF THE BODY Thymus 123 Thymus, newborn THYMUS RETICULUM FRAMEWORK - EPITHELIUM EPITHELIUM 116 Lymph node Afferent lymphatic duct Lymph node follicle Germinal center Lymphocyte Reticulum cell 116 Lymph node Afferent lymphatic duct Subscapular space Parafollicular region
High endothelial cells of a venule Parafollicular region High endothelial cells of a venule
parafollicular region High endothelial cells of a venule INDUCTION OF RESPONSE PERIPHERAL ORGAN NEEDED TO GET ANTIGEN AND RESPONSIVE CELL TO INTERACT LYMPHOCYTE RECIRCULATING APPROPRIATE CONTEXT 19754 Lymphatic sinus in lymph node Venous sinus Medullary cord Lymphatic sinus or Medullary sinus
Lymph node medulla: Reticulum cell Lymphocyte Plasma cell Medullary cord Lymphatic sinus or Medullary sinus Lymphatic sinus or Medullary sinus
Macrophages in the lymph node medulla Macrophages Efferent lymphatic duct? 116 Spleen Spleen (reticulum stain)- capsule and reticulum fibers
218 Spleen (reticulum stain)- capsule and reticulumfibers 122 Spleen Spleen red and white pulp
122 Spleen: Central artery Periarteriolar lymphatic sheath Red pulp Spleen 122 Marginal zone Spleen 122 central artery PENICILLARY ARTERIES Marginal zone Splenic red pulp: Venous sinus Littoral cell Billroths strand Spleen reticulum: Reticulum fiber Billroths strand Sinuses Litteral cells of spleenic venial Spleen #19752 (UT117) Tonsil 419 Tonsil Tonsil 419 Esophagus and trachea, monkey
242 Esophagus and trachea, monkey 145 Fundic stomach Large intestine or Colon, monkey
153 Large intestine or Colon, monkey Plasma cells large intestine in Colon, monkey
153 Plasma cells large intestine in Colon, monkey 32412 EM 6 Image 112 LIFE CYCLE OF LYMPHOCYTES
FETAL ORGANS BONE MARROW PRIMARY LYMPHOID ORGANS (ANTIGEN INDEPENDENT DEVELOPMENT) - THYMUS - T LYMPHOCYTES - BONE MARROW - B LYMPHOCYTES SECONDARY LYMPHOID ORGANS (ANTIGEN DEPENDENT DEVELOPMENT) LYMPH NODES LYMPHOID NODULES SPLEEN ONTOGENY STEM CELLS - BONE MARROW PRIMARY LYMPHOID ORGANS
SECONDARY LYMPHOID ORGANS DIFFERENTIATION TO MATURE ANTIGEN REACTIVE CELLS thymus Bone marrow