Lymphocyte development

Wilaiwan Petsophonsakul

Contents

• Overview of lymphocyte development

• Stage of B cell maturation

• Selection of the mature B cell repertoire in bone marrow

• Stage of T cell maturation

• Role of the thymus in T cell maturation

• Section processes in the maturation of MHC-restricted ab T cells

• Antigen receptor gene rearrangement and expression

• Commitment to the B and T Cell Lineages

Development of B and T cells

Pluripotent stem cells give rise to distinct B and T lineages

FO B = Follicular B-2 B cell

MZ B = marginal B-2 B cell

B-1B = B-1 cell

ab T = ab T cell gd T = gd T cell ILC = innate lymphoid cell

Lymphocyte maturation

Diversity in Ig and TCR genes

B cell maturation

The development of B cells

B cell subsets

B cell selection in bone marrow

Stage of B cell maturation

T cell maturation

T cell development

T cell maturation

Thymic selection

Self MHC restriction

Self tolerance

The function of AIRE in deletion of T cells in thymus

Thymocytes of different developmental stages

Stage of T cell maturation

Checkpoints in lymphocyte maturation