LSM3212_Lecture 1 Introduction

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    Human Physiology: LSM 3212An Introduction:

    The application of Human Physiology in exerciseand sports performance

    1

    A/Prof Lim Chin LeongBSc, MSc, MBA, PhD

    Programme Director,Combat Protection and Performance

    DMERI@[email protected]

    Dept of Physiology,NUS NCAPSSC Singapore Institute of Clinical SciencesA*STAR

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    Human Physiology

    The study of humanbody functions

    Human Anatomy

    The study of humanstructure and morphology

    2

    FunctionsSystemsOrgansCellsProtein

    formationRNA

    formationDNA

    formation

    The Organization of Human Physiology

    StrengthMuscularNervousSkeletalMetabolic

    MusclesNerves

    GlycolysisM. typeM. FibersM. Fibrils

    MyosinActin

    ExpressionRegulatione.g., ACTN3,IFG-1

    ExpressionRegulatione.g., ACTN3

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    Physiological Systems of the Human

    Cardiovascular

    Cardiopulmonary

    Muscularskeletal

    Digestive

    Cognition

    3

    Endocrine

    NervesUrinary

    Immune

    Metabolism

    Thermoregulation

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    Physiological Systems of the Human

    Cardiovascular

    Cardiopulmonary

    MuscularSkeletal

    Metabolism

    Digestive

    Cognition

    4

    Endocrine

    NervesUrinary

    Immune

    Thermoregulation

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    Physiological Systems of the Human

    Cardiovascular

    Cardiopulmonary

    MuscularSkeletal

    Metabolism

    Digestive

    Cognition

    5

    Endocrine

    Nerves

    Urinary

    Immune

    Thermoregulation

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    Extremes of Physiological Systems in Sport

    Cardiovascular

    Cardiopulmonary

    MuscularSkeletal Metabolism

    Digestive

    6

    Endocrine

    Nerves Urinary

    Immune

    Thermoregulation

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    HomeostasisThe body will function to preserve its physiological

    equilibrium in order to survive the demands of theenvironment.

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    Immediate adaptation e.g., heart rate, body temperature andenergy production.

    Chronic adaptation

    Longer term adaptation e.g., changes in fitness and performancelevels and body composition.

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    Healthy and at rest

    Physical exertionIllness /

    The Dimensions of Physiological State and Homeostasis

    Non-survival /Chronic injury

    Shift in baseline physiology to

    survive at a new state ofexistence. Key issues: Acute adaptation Chronic adaptation

    8

    Extreme PerformanceOver exertion

    Challengeto regulate

    Limits of regulation

    Dysregulation

    ar a ons n a ap a on Limits of adaptations Mechanisms of adaptation Interpretation of physiology

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    Exercise is a Form of Stress

    9

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    STRESS :

    Stressor: The source of the stress

    Demands an adaptation from the body

    10

    ustress: e goo stress

    Distress: The bad stress

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    THE STRESS CONTINUUM

    EustressImproved fitness

    DistressBurnout

    EXERCISE

    11

    Cope better with daily

    tasks

    Improved self-image &confidence

    Stronger immune system

    Injury

    Substance abuse

    Distorted self-image

    e.g muscle dysmorphia,

    aneroxia nervosa.

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    STRESS ADAPTATION SYNDROME

    NCE

    PEAK

    12

    PERFORM

    ALARM

    TIME

    ADAPTATION FATIGUE

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    Physical Activity / Exercise

    Health

    Driven

    Performance

    Driven

    Purpose / Motivation

    Stress

    Commitment

    Intensity / Pain

    Outcome

    Time span

    Sacrifice

    Health risk

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    Health Benefits of Exercise

    14

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    Health Benefits of Exercise

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    Are fitness and health the same??

    HealthFitness

    Physical Exercise

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    Fitness and Health Relationship

    HealthFitness

    Health BenefitsIndividual risks

    Gill and Cooper Sports Med 2008

    Physical Exercise

    Aerobic capacityBody compositionMuscular strengthMuscular enduranceMuscular speed

    FlexibilityAgilityCoordinationEndurance

    ObesityInsulin resistanceGlucose toleranceLipid profileCV health

    Blood pressureBone densitySoft tissueMental health

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    The Continuum of Human Performance

    ical

    rmance Negative return

    Neutral return

    Positive return

    Untrained Optimal Maximal Over

    Phy

    Perf

    Training Volume

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    Intense Exercise: A Double Edged Sword

    Execution of Training

    Desired outcome Disastrous outcomeUndesired outcome

    19Training Load

    StressTolerance

    Limit of Tolerance+ve Adaptation

    -ve Adaptation

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    20

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    INDIVIDUAL DIFFERENCES IN RESPONSE

    TO TRAINING

    Variations in improvement inVO2 max following 20 weeks

    of endurance training byfamily.

    Average was 18% but the

    21

    range was .

    The range was influenced bygenetics but was influencedvery little by age, sex andrace.

    Adapted from C. Bouchard et al., 1999, Familiaraggregation of VO2 max response to exercisetraining. Results from HERITAGE Family Study,Journal of Applied Physiology 87: 10031008.

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    Cardiopulmonary and Vascular Systems

    Heart

    Lungs

    Blood vessels

    Arteries: transport oxygenated blood

    : transport blood from the

    heart to the organs/ muscles

    Veins: transport deoxygenated

    blood

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    : transport blood from organsto the heart

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    CAPACITY OF THE LUNG

    24

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    Primary Roles of the Pulmonary System

    during Exercise

    Inhalation of oxygen.

    Oxygen supply

    Diffusion of O2 into the pulmonary vein capillaries.

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    CO2 removal

    Diffusion of CO2 from Pulmonary artery capillaries into thealveoli.

    Exhalation of carbon dioxide

    Acid - Base balance.

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    CARDIOVASCULAR SYSTEM

    26

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    FUNCTIONS DURING EXERCISE

    Transportation of oxygen to exercisingmuscles.

    Removal of carbon dioxide and lactatefrom exercising muscles.

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    exercising muscle.

    Removal of heat from exercisingmuscle.

    Transportation of heat to skin surface.

    Maintenance of blood flow.

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    Autonomic Nervous System

    Part of peripheral nervoussystem that coordinates thefunctions of major organs

    Activated mainly by the spinalcord, brain stem andhypothalamus

    Major organs under the control ofthe ANS:

    Heart

    Bronchus

    28

    Comprises of sympathetic andparasympathetic systems

    SNS: Fight or flight system

    PSNS: Promotes functions ofthe resting state.

    Stomach

    Kidney

    Blood vessels

    Intestines

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    Key Roles of ANS During Exercise

    Heart rate

    Stroke volume

    Cardiac output

    VO2

    Blood pressure

    29

    Blood distribution

    Thermoregulation

    Sweating

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    Unnatural Alteration of Physiology

    for Sports Performance

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    Breakdown of the ancient Olympic games some2000 years ago was due to political interferenceand the use of drugs.

    The first reported death from doping occurred in1886 when a cyclist, Arthur Linton, took caffeine.

    History of Doping Cases in Sports

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    The first near death in the modern Olympicsoccurred in 1904 when Thomas Hicks, collapsedafter taking a mixture of brandy and strychnine in amarathon.

    Danish cyclist Knut Jensen collapsed and died inthe heat of the Rome Olympics in 1960 after takingronicol tablets and amphetamines in the belief thatthey would increase blood flow through his

    muscles.

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    In 1986 European Champion shot-putter Heidi Krieger was a long termuser of male hormone injections

    under state run doping programmesin East Germany.

    I was no longer Heidi Krieger. I

    History of Doping Cases in Sports

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    n t now anymore w o was

    wasnt able to identify with my bodyanymore, and that led me toundergo a sex change

    Today Krieger is a gruff-voiced 40-year old man called Andreas.

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    Ben Johnson (Canada)tested positive for anabolicsteroids at Seoul in 1988.

    1984: LA Olympics, Bronze100 m

    1984: LA Olympics, Bronze,

    History of Doping Cases in Sports

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    1987: World Championship,Disqualified, 100m

    1988: Seoul Olympics,

    Disqualified, 100m

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    Floyd Landis, winner of the2006 Tour de France winnerFloyd Landis.

    Overcame a normallyinsurmountable 8 min deficitin the final days of the 3-week race.

    History of Doping Cases in Sports

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    Tested positive for syntheticsteroids in 17 of his urinesample after his winningrace.

    Spent about US$2 Mil in hisdefence.

    Stripped of his title in 2007