LORRAINE B. WARE, MD · CURRICULUM VITAE LORRAINE B. WARE, MD Date of Birth: November 26, 1966 San Diego, California Business Address: Center for Lung Research T-1218 Medical Center

Date Updated: 8/23/2017

CURRICULUM VITAE

LORRAINE B. WARE, MD

Date of Birth: November 26, 1966

San Diego, California

Business Address: Center for Lung Research

T-1218 Medical Center North

Vanderbilt University School of Medicine

Nashville, Tennessee 37232-2650

Marital Status: Reid C. Thompson, M.D.

EDUCATION:

09/84-05/88 B.A., Claremont McKenna College, Claremont, California

09/88-05/92 M.D., Johns Hopkins University, Baltimore, Maryland

POSTGRADUATE TRAINING:

07/92-06/95 Osler Internship and Residency in Internal Medicine, Johns Hopkins University, Baltimore,

Maryland

07/96-06/99 Postdoctoral Fellow, Pulmonary and Critical Care Medicine, University of California, San

Francisco, California

07/97-08/01 Postdoctoral Fellow, Cardiovascular Research Institute, University of California, San Francisco,

California

LICENSURE AND CERTIFICATION:

Maryland Medical License: D47486 (1995-1997)

California Medical License: A60136 (1996-2003)

Tennessee Medical License: 36159 (2002-Pres.)

DEA License: # BW 7713476

American Board of Internal Medicine Certifications:

Internal Medicine, 1995; Recertified 2005, 2015

Pulmonary Diseases, 1998; Recertified, 2008

Critical Care Medicine, 2000; Recertified, 2010

Ware, Lorraine B., M.D.

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ACADEMIC APPOINTMENTS:

07/95-06/96 Instructor in Medicine, Division of Internal Medicine, The Johns Hopkins University School of

Medicine, Baltimore, Maryland

09/01-03/02 Clinical Instructor in Medicine, Division of Pulmonary and Critical Care Medicine, University

of California at Los Angeles, Los Angeles, California

03/02-6/08 Assistant Professor of Medicine, Department of Medicine, Vanderbilt University School of

Medicine, Nashville, Tennessee

7/08-6/14 Associate Professor of Medicine with Tenure, Department of Medicine, Vanderbilt University

School of Medicine, Nashville, Tennessee

01/12-6/14 Associate Professor of Pathology, Microbiology and Immunology, Vanderbilt School of


7/14 – Pres. Professor of Medicine with Tenure, Department of Medicine, Vanderbilt University School of


7/14 – Pres. Professor of Pathology, Microbiology and Immunology, Department of Medicine, Vanderbilt

University School of Medicine, Nashville, Tennessee

HOSPITAL APPOINTMENTS:

2002-2008 Attending Physician, Department of Veterans Affairs Medical Center, Nashville, Tennessee

2002-Pres. Attending Physician, Vanderbilt University Medical Center, Nashville, Tennessee

HONORS AND AWARDS:

1984-1988 Distinguished Scholar, Claremont McKenna College

1986 Sigma Xi Scientific Research Society

1988 Graduated Summa Cum Laude with Honors in Chemistry and Biology, Claremont McKenna

College

1988 Berger Outstanding Senior Student Award

1988 Senior Science Award, Claremont McKenna College

1988 Phi Beta Kappa

1984-1988 McKenna Achievement Award

1988-1990 Pfeiffer Foundation Scholarship in Pharmacology and Molecular Sciences

1992 Alpha Omega Alpha Honor Medical Society

1992 Achievement Award, American Medical Women’s Association

1992 Hewlett Packard Top Medical Student Award

2000 American Lung Association of San Francisco and San Mateo Counties Walter Travel Fund

Award

2005 Judge Sidney H. Reiss Award for Teaching Excellence in Pulmonary Medicine

2008-2013 American Heart Association Established Investigator Award

2009 Finalist, Burroughs Wellcome Fund Clinical Scientist Award in Translational Research

2012 American Society of Clinical Investigation

2013 American Physiological Society Citation for Distinguished Service

2014 Highlighted abstract, American Thoracic Society International Conference (senior author)

2015 Highlighted abstract, American Thoracic Society International Conference (first author)

2015 American Thoracic Society Recognition Award for Scientific Accomplishments

2016 Recognition Award for Extraordinary Research in Lung Disease, American Lung Association of

Tennessee


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PROFESSIONAL ORGANIZATIONS:

1996-Pres. American Thoracic Society

Membership Committee (2002-2004)

Critical Care Programming Committee (2006-2007)

Co-Chair, Clinical Year in Review Committee (2006-2009)

Critical Care Planning Committee (2007-2009)

Respir. Cell and Molecular Biology Programming Committee (2010-2013)

Critical Care Assembly Mentoring Program (2014-Pres.)

Awards Committee (2015-2018)

Critical Care Assembly Nominating Committee (2017-19)

1996-Pres. American College of Chest Physicians (elected Fellow in 2002)

2003-Pres. Society of Critical Care Medicine

2003-Pres. American Physiological Society

2008-Pres. International Society of Heart and Lung Transplantation

2012-Pres. American Society of Clinical Investigation

PROFESSIONAL ACTIVITIES:

INSTITUTIONAL SERVICE (Committees, Councils, Task Forces)

Committee Member, Internal Medicine Residency Selection Committee, Johns Hopkins Hospital, Baltimore,

Maryland, 1995-1996

Participant, Faculty Development Course, The Johns Hopkins University School of Medicine, Baltimore,

Maryland, 1995-1996

Member, Data Safety and Monitoring Board: "BK Receptor Antagonism During Cardiopulmonary Bypass."

Principal investigator: Dr. Mias Pretorius, Department of Anesthesiology, Vanderbilt University School of

Medicine, Nashville, Tennessee, 2005-2009.

Member, Vanderbilt Center for Human Genetics Research, 2006 – present

Member, Data Safety and Monitoring Board: “The effects of intensive insulin therapy on somatic and visceral

protein turnover in acute kidney injury (AKI).” Principal investigator: Dr. Alp Ikizler, Department of Medicine,

Vanderbilt University, 2006 – 2010.

Member, Vanderbilt Task Force on “Getting Medicines Right”, 2020 Personalized Medicine Initiative, 2009.

Expert Consultant, Vanderbilt Institute for Clinical and Translational Research Studio Program, 4 – 6 Studios/year,

2009 – present.

Member, Vanderbilt Medical School Admissions Committee, 2010 – 2012.

Chair, Data Safety and Monitoring Board: “The ACT-ICU Study”. Principal Investigator: Dr. Nathan Brummel,

Department of Medicine, Vanderbilt University, 2011 – 2012.

Co-Director, Clinical and Translational T32 Research Training Program in Pulmonary Medicine, 2011 – present.

Co-Chair, Department of Medicine Research Council, 2011 – 2014.

Member, Vanderbilt Physician Scientist Development Program Study Section. 2012- present.

Member, Vanderbilt Edge for Scholars Internal Study Section, 2013 - present

Member, Limited Submissions Opportunities Internal Review Committee, 2013 – present.


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Member, Vanderbilt Medical School Executive Admissions Committee, 2012 – 2014.

Thesis Committee Member, Department of Pathology, Microbiology and Immunology, for Yin Guo, PhD

candidate. 2012 – 2016.

Promotions Committee Member, Immersion Phase, Doctor of Medicine program, 2016-2020.

Member, Medical Scientist Training Program Admissions Committee, 2017-present.

Director, Vanderbilt Medical Scholars Program, 2012- present.

TEACHING (past and present)

1995-1996 Faculty Preceptor, Medicine Housestaff Clinic, The Johns Hopkins University School of

Medicine, Baltimore, Maryland

1996-2001 Lecturer, Department of Medicine and Pulmonary and Critical Care, University of

California at San Francisco, San Francisco, California

2001-2002 Attending Physician, Pulmonary Consultant Service and MICU, University of California

at Los Angeles, Los Angeles, California

2002-2006 Attending Physician, Pulmonary Consult Service and MICU, Department of Veterans

Affairs Medical Center, Nashville, Tennessee

2002-Pres. Attending Physician, Pulmonary Consult Service and MICU, Vanderbilt Medical Center,

Nashville, Tennessee

2005-Pres. Course Director: "Clinical Proteomics," Vanderbilt Masters in the Science of Clinical

Investigation (MSCI) elective.

2009 – 2013 Small Group Leader, Capstone Course for 4th

year Medical Students, Vanderbilt

University Medical Center, Nashville, Tennessee

2009 - 2013 Lecturer, Disease, Diagnosis and Therapeutics Course for 2nd

year Medical Students.

“ARDS: Pathology, Pathophysiology and Therapy.” Vanderbilt Medical School.

2009 – 2013 Lecturer, Microbiology and Immunology 501 Course for 1st year Medical Students.

“Anaphylactic Shock.” Vanderbilt Medical School.

2012 – Pres. Preceptor, Internal Medicine Resident’s Journal Club

2014 – Pres. Lecturer, Homeostasis Block in Curriculum 2.0 for 1st year Medical Students. “Acute

Respiratory Distress Syndrome”. Vanderbilt Medical School.

CURRENT TRAINEES:

2012–Pres. Ciara Shaver, M.D.,Ph.D., Assistant Professor of Medicine, Vanderbilt University

Dr. Shaver is studying the effect of cell-free hemoglobin on macrophage phenotype and

lung inflammation. She received the 2014 Vanderbilt Research Forum Prize for best

clinical research and 2015 Vanderbilt Research Forum Best Poster Prize. She is the

recipient of an NIH T32 grant award, a Vanderbilt Faculty Scholars Research award, an

American Thoracic Society research grant, a Parker B. Francis fellowship and an NIH

K08 award.


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2012-Pres. Kirsten Kangelaris, MD, Assistant Professor of Medicine, UCSF

As a postdoctoral fellow and now junior faculty mentor under the co-mentorship of Drs.

Michael Matthay, Carolyn Calfee and Ware, Dr. Kangelaris has been studying predictors

of long term mortality in ARDS. She is the recipient of an NIH K23 award.

2012 – Pres. Joshua Diamond, M.D., Assistant Professor of Medicine, U Penn

Under the co-mentorship of Dr. Jason Christie and Dr. Ware, Dr. Diamond has been

studying the pathophysiology of primary graft dysfunction after lung transplantation. He

is the recipient of an NIH K23 award.

2014 – Pres. Angela Rogers, M.D., Assistant Professor of Medicine, Stanford University

Under the co-mentorship of Dr. Michael Matthay and Dr. Ware, Dr. Rogers is studying

the pulmonary edema fluid metabolome in ARDS. She received an American Thoracic

Society research grant and an NIH K23 award.

2014-Pres. Ryan Brown, M.D., Pulmonary and Critical Care Fellow, Vanderbilt University

Dr. Brown has been studying provider recognition of ARDS in patients at risk for ARDS

due to severe trauma or other critical illness.

2016-Pres. Eric Kerchberger, M.D., Pulmonary and Critical Care Fellow, Vanderbilt University

Under the co-mentorship of Dr. Julie Bastarache and Dr. Ware, Dr. Kerchberger is

studying the role of haptoglobin 1:2 genotype in cell-free hemoglobin mediated organ

dysfunction. He is the recipient of an NIH T32 training award in Anesthesia Critical Care.

2016-Pres. Shaina Johnson, M.D., Pediatric Hematology Fellow, Vanderbilt University

Under the co-mentorship of Dr. Michael Debaun and Dr. Ware, Dr. Johnson is studying

the role of cell-free hemoglobin and haptoglobin genotypes in acute chest syndrome in

sickle cell disease. She is the recipient of an NIH T32 training grant award.

2016-Pres. Katie DesPrez, B.S., Medical Student, Vanderbilt University School of Medicine

Ms. DesPrez is studying the use of the SpO2/FiO2 as a substitute for the PaO2/FIO2 ratio

in calculating the Oxygenation Index for assessment of severity of hypoxemia in ARDS.

2016-Pres. Karen Jackson, M.D., Internal Medicine Resident, Vanderbilt Medical Center

Dr. Johnson is studying the value of serum albumin levels in predicting outcome and

response to therapy in ARDS.

2017-Pres. Holly Sucharski, B.S., Graduate Student, Vanderbilt University.

Ms. Sucharski is studying the role of tissue factor in the alveolar epithelium in

maintaining alveolar barrier integrity through interactions with beta-1 integrin.

2017-Pres. Wen-Kuang (Elmer) Yu, Visiting Physician, Taipei Veterans General Hospital, Taiwan

Dr. Yu is studying the effect of cell-free hemoglobin on primary isolates of mouse and

human alveolar epithelial type II cells

PAST TRAINEES:

2003-2008 Ling Wang, M.D., Research Assistant Professor, University of Pittsburgh.

As a postdoctoral fellow with Dr. Ware, Dr. Wang studied the role of the alveolar

epithelium in modulating the intra-alveolar activation of protein C, an endogenous

anticoagulant.

2004-2005 Nimet Browne, B.S., Doctor of Veterinary Medicine

Ms. Browne’s research focused on developing a new method to measure the rate of

alveolar fluid clearance in anesthetized piglets.


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2005-2007 Minerva Covarrubias, M.D., Formerly Assistant Professor of Medicine and Director of

Critical Care Medicine, Meharry Medical College, Nashville TN, now in private practice.

As a postdoctoral fellow in Dr. Ware’s lab, Dr. Covarrubias received an NHLBI funded

supplement for diversity in biomedical research to fund her lung transplant studies as

well as a 2006 American Thoracic Society Minority Trainee Travel Award.

2006-2008 Eric Austin, M.D. Associate Professor of Pediatrics, Vanderbilt University.

Under the co-mentorship of Dr. Ware and Dr. James Loyd, Dr. Austin’s research focused

on the discovery and validation of novel biomarkers of familial and idiopathic pulmonary

hypertension that might be used for non-invasive early detection. He received NIH K12

and K23 awards and a Vanderbilt University Clinical Research Scholars program award.

His research has been recognized with a Junior Researcher/ Investigator Travel Award

and a Junior Investigator Excellence Award: ‘1st Place’ at the 4th World Symposium on

Pulmonary Hypertension 2008, as well as an American Thoracic Society Travel Award.

2006-2008 Richard Fremont, M.D., Associate Professor of Medicine, Meharry Medical College

Dr. Fremont was a postdoctoral fellow in Dr. Ware’s lab. During his training he

developed a biomarker panel for diagnosis of ARDS in patients with severe trauma.

Working with Dr. Ware he also received an award from the Vanderbilt GME office to

develop an online curriculum for teaching in the Intensive Care Unit.

2007-2008 Jonathan Kropski, M.D., Assistant Professor of Medicine, Vanderbilt University

During a 4-month research elective during his 4th

year of medical school, Dr. Kropski

investigated the release of Clara Cell Specific Protein into the airspaces and plasma of

patients with acute lung injury. His abstract submission was one of only three clinical

abstracts chosen for oral presentation at the Vanderbilt Research Forum in April 2008.

2007-2009 Hollis O’Neal, M.D. Assistant Professor of Medicine, LSU, Baton Rouge

Dr. O’Neal’s research focused on the role that pre-hospitalization exposure to statin

therapy has on the risk of developing acute lung injury in the setting of risk factors

including sepsis and pneumonia. His research was recognized with an American

Thoracic Society PAR Member ARDS Foundation Travel Award.

2007-2009 Fred Bossert. Obstetrics and Gynecology Resident, UT Chattanooga

Mr. Bossert studied new methods for singleplex and multiplex assays of diagnostic and

prognostic biomarkers for clinical use in acute lung injury and acute kidney injury.

2008-2012 Carolyn Calfee, MD, Associate Professor of Medicine, UCSF

Under the co-mentorship of Dr. Michael Matthay and Dr. Ware, Dr. Calfee developed an

extensive research program focused on biomarkers of ARDS and the effect of cigarette

smoking on the risk of ARDS that has been funded by an NIH K23 award and several

NIH R01 awards.

2008-2009 Blake Curtis, Radiology resident, University of Tennessee Memphis

Mr. Curtis’s project focused on validating a chest radiographic scoring system to quantify

the degree of pulmonary edema.

2009 Frank Qian, College Student.

Frank participated in the Vanderbilt Center for Science Outreach

Summer Internship Program. His project focused on the effect of statins on alveolar

epithelial tissue factor expression.

2010-2011 Nicolas Barnett, M.D., Attending Anesthesiologist, London, United Kingdom.


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Dr. Barnett studied the effect of prehospital Vitamin D status on risk of sepsis and acute

lung injury in critical illness. He received a Vanderbilt Institute for Clinical and

Translational Research Award to fund his project

2010-2011 Chen Yu Wang, M.D., Attending Physician, Taichung Veterans General Hospital,

Taichung, Taiwan.

Dr. Wang studied the determinants of long term mortality after hospitalization for acute

lung injury and other critical illness. He received an award from the Vanderbilt Institute

for Clinical and Translational Research to fund his project.

2010-2012 Yosaf Zeyed, M.D., Cardiovascular anesthesia fellow, University of Miami.

Dr. Zeyed studied the role of circulating microRNA as a biomarker and indicator of

pathogenesis of clinical acute lung injury. He was the recipient of a Vanderbilt Institute

for Clinical and Translational Research award to fund his research and completed his

MSCI training under Dr. Ware’s supervision.

2010-2012 Jennifer Clune, M.D., private practice, Dayton, Ohio.

Dr. Clune studied the role of tissue factor deletion in lung epithelium and myeloid cells

in the pathogenesus of acute lung injury.

2009-2012 Sara Sebag, Ph.D. Research Scientist, University of Iowa

Dr. Sebag studied the effect of cyclic mechanical strain in vitro and in vivo on

mechanisms of fibrin deposition in acute lung injury. Dr. Sebag was the recipient of an

NIH T32 training award.

2012 Andrew Taliaferro. Medical Student, Harvard Medical School

Mr. Taliaferro studied the relationship between organ donor smoking and physiologic

outcomes in the resected human lung including the degree of pulmonary edema and the

rate of alveolar epithelial fluid clearance.

2012-13 Devon Paul, M.D. Pulmonary and Critical Care fellow, Duke University

Dr. Paul studied causes of long term mortality in survivors of sepsis and ARDS.

2012-13 Gregory Shemancik, Undergraduate Student, Allegheny University

Mr. Shemancik spent two summers in the lab studying the effect of free hemoglobin on

lung epithelial cells in culture.

2003-2013 Julie A. Bastarache, M.D., Assistant Professor of Medicine, Vanderbilt University

Dr. Bastarache’s work as a postdoctoral fellow and now faculty member has focused on

how the human alveolar epithelium can initiate the extrinsic coagulation cascade through

the expression of tissue factor in response to an inflammatory stimulus. She is the

recipient of a Vanderbilt Physician Scientist Development Award, an NIH BIRCWH K12

award, an NIH loan repayment award, an NIH K08 award and NIH R01 funding.

2005-2013 Timothy Girard M.D., Associate Professor, University of Pittsburgh

Under the co-mentorship of Dr. Ware and Dr. Wes Ely during his fellowship training and

fellow-to-faculty transition, Dr. Girard studied biomarkers of delirium and long term

cognitive dysfunction in critically ill patients. He has received the Vanderbilt Physician

Scientist Development Award, a Hartford Geriatric Health Outcomes Research Scholars

Award, and an NIH K23 award.

2006-2013 Edward Siew, M.D., Associate Professor of Medicine, Division of Nephrology

Under the co-mentorship of Dr. Ware and Dr. Alp Ikizler during his fellowship training

and fellow-to-faculty transition, Dr. Siew’s research focused on the discovery and

validation of novel biomarkers of acute kidney injury in critically ill patients. Dr. Siew

received a Vanderbilt Clinical Research Scientist Award to fund his transition from


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Fellow to Junior Faculty, a National Kidney Foundation Research Fellowship Award, an

NIH K23 award and currently has a VA Merit Award.

2010–2014 David R. Janz, M.D., Assistant Professor of Medicine, LSU New Orleans

Dr. Janz was a postdoctoral fellow with Dr. Ware. He studied the effect of cell-free

hemoglobin on organ injury in sepsis and critical illness. He received multiple grants

from the Vanderbilt Institute for Clinical and Translational Research to fund his projects

and was the recipient of an American Thoracic Society International Conference Travel

Award and an NIH T32 Training Grant award.

2011-2015 Rupal Shah, MD. Assistant Professor of Medicine, UCSF

As a postdoctoral fellow under co-mentorship of Dr. Jason Christie and Dr. Ware, Dr.

Shah studied biomarkers for diagnosis and prediction of primary graft dysfunction after

lung transplantation.

2013- 2014 Wei (Peter) Chen, MD, Critical Care Physician, Taiwan.

Dr. Chen was a visiting scientist in Dr. Ware’s laboratory. He studied the utility of the

SpO2/FIO2 ratio compared to the PaO2/FIO2 ratio for diagnosis of ARDS.

2012- 2014 Derek Russell, M.D., Pulmonary and Critical Care Fellow, U Alabama Birmingham

Dr. Russell studied the effect of hyperoxia during trauma resuscitation on clinical

outcomes during his internal medicine residency.

2012- 2014. Cameron Upchurch, Emergency Medicine Resident, University of Michigan.

During medical school, Dr. Upchurch studied the effect of cell-free hemoglobin on lung

epithelial cells in culture. He was a finalist for the 2014 Vanderbilt Research Forum

Basic Science Award and has received the Vanderbilt Medical Scholars award.

2013 Ma Li, MD, PhD, Vice Head of Critical Care Medicine, Wuxi City, China

Dr. Ma Li was a visiting physician scientist in Dr. Ware’s laboratory. She studied the

effect of bleomycin-induced acute lung injury on tissue factor expression in the mouse

lung.

2013 –2015 Hiromasa Nagata, M.D., Attending Anesthesiologist, Keio University, Japan.

Dr. Nagata developed a human model of acute lung injury in isolated perfused human

lungs obtained from organ donors. He received an award from the Vanderbilt Institute of

Clinical and Translational Research to fund his research project.

2013-2105 Sharidan Parr, M.D, Clinical Research Instructor, Vanderbilt University

As a postdoctoral fellow under the co-mentorship of Dr. Siew and Dr. Ware, Dr. Parr

studied biomarkers for early identification of acute kidney injury. She is the recipient of

a Vanderbilt Bioinformatics Fellowship award.

2014-2015 Liang Luo, M.D., Ph.D., Attending Physician, Nanjing Medical University School of

Medicine, Wuxi City, China. As a visiting scientist in Dr. Ware’s laboratory, Dr. Luo

studied clinical characteristics and clinical outcomes of ARDS due to direct versus

indirect mechanisms of lung injury.

2014- 2016 Jamie Kuck, Ph.D., Medical Student, University of Alabama Birmingham

As a postdoctoral fellow, Dr. Kuck studied the mitochondrial effects of cell-free

hemoglobin in lung endothelial and epithelial cells.

2016 Kelsey Auman, Undergraduate Student, Vanderbilt University

Ms. Auman studied degradation of the glycocalyx in the isolated perfused human lung.

2013 – 2017 Melissa Warren, M.D., Assistant Professor of Medicine, Vanderbilt University


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During her postdoctoral research training, Dr. Warren studied the role of chest

radiographic scores in quantitative assessment of the extent of pulmonary edema in

ARDS and in organ donors. She received a 2016 American Thoracic Society Assembly

on Critical Care Abstract Scholarship Award and a 2017 American Thoracic Society

ARDS Foundation Abstract Award.

2015-2017. Laura Murphy, B.S, Emergency Medicine Resident, Vanderbilt University Medical

Center. As a medical student, Ms. Murphy studied the utility of syndecan-1 as a

biomarker of ARDS and severity of endothelial injury in patients with severe sepsis.

2015-2017 Melinda Paul, B.S., former medical Student, Meharry Medical College

Ms. Paul studied mechanisms of free-hemoglobin associated acute kidney injury in sepsis

using renal tubular epithelial cells in culture and a mouse model of acute peritonitis. She

is the recipient of a Vanderbilt Medical Scholars award and an NIH NHLBI Diversity

Supplement.

2013-2017 David Botschner, B.S., Medical Student, University of Toledo

As an undergraduate and after his first year of medical school Dr. Botschner worked with

Dr. Ware on various research projects including the effect of cell-free hemoglobin on cell

respiration in pulmonary microvascular endothelial cells.

EXTRAMURAL ACTIVITIES

Committees, Working Groups, Data Safety and Monitoring Boards:

Treasurer, American Medical Student Association, Johns Hopkins Chapter, 1989-1991.

Representative of the Johns Hopkins Chapter, American Medical Student Association National Convention,

1989

Participant, NHLBI Workshop on Clinical Research, American Thoracic Society International Conference,

Atlanta, Georgia, 2002.

Member, Working Group on Primary Graft Failure, International Society of Heart and Lung

Transplantation. Convened September, 2003.

Juror, International Consensus Conference. "Necrotizing Pancreatitis: Consensus, Controversy and

Challenge." Washington, D.C., April 15-16, 2004.

Ad hoc Member, Career Advisory Committee for Carolyn Calfee, M.D., Postdoctoral Fellow,

Cardiovascular Research Institute, San Francisco, California, 2005-2010.

Member, Steering Committee, NIH NHLBI Clinical Proteomics Program, 2005-2009.

Member, Data Safety and Monitoring Board, The HEAL Trial--Hemodynamics and Extravascular Lung

Water in Acute Lung Injury. Principal Investigator, Charles Phillips, 2006-2008.

Chair, Steering Committee, NHLBI Clinical Proteomics Programs, 2006-2007.

Member, SCCM-ATS-ACCP Task Force on the Role of Clinical Research in Critical Care Medicine. 2009

– 2010.

Member, Editor Search Committee, American Journal of Respiratory and Critical Care Medicine, 2009.

Panel Member and Speaker, NHLBI Workshop on Clinical Trials in Acute Lung Injury: Beyond Mortality.


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Bethesda, MD, August, 2009.

Panelist and Invited Speaker. The Roundtable on U.S. Critical Care Policy. Washington D.C., October,

2009.

Member, Data Safety and Monitoring Board. A Randomized Double-Blind Placebo-Controlled Trial of

Ganciclovir and Valganciclovir for Prevention of CMV Reactivation in Acute Lung Injury. Principal

Investigator, Michael Boeckh, MD, 2010-2016.

Member, NHLBI Working Group: Optimizing the NHLBI Biologic Specimen Repository. Bethesda, MD,

September, 2010.

Member, NHBLI Biorepository Expert Panel, 2011- 2013.

Member, Data Safety and Monitoring Board. Vitamin C Infusion for TReatment In Sepsis Induced-Acute

Lung Injury. (CITRIS-ALI). Principal Investigator, Alpha Fowler, MD, Virginia Commonwealth

University. 2013-present.

Member, Board of Medical Directors. The ARDS Foundation. 2013-present.

Fellowship Officer, Howard Hughes Medical Institute Medical Research Fellows Program, 2012 – present.

Member, Advisory Board, Osler Medical Residency, Johns Hopkins School of Medicine. 2016 - present.

External Advisory Board, Aspen Lung Conference. 2015 – present.

Member, Data Safety and Monitoring Board. Serial, Non-Invasive Molecular Analysis of Exhaled Breath

Condensate to Define the Pulmonary Flora in Critically Injured, Ventilated Adults. Principal Investigator

Addison May, MD, Vanderbilt University Medical Center 2016 – present.

Chair, NHLBI Data Safety and Monitoring Board. Phase I, open label study to evaluate adenosine 2a

receptor agonist (Regadenoson) in patients undergoing lung transplantation. Principal Investigator

Christine Lau, MD, University of Virginia. 2016 – present.

Participant and invited speaker, National Heart Lung and Blood Institute and American Association of

Thoracic Surgeons Workshop: “Identifying collaborative clinical research priorities in lung transplantation.”

Bethesda, MD. June 2017.

Service at National and International Conferences

Facilitator: “Ventilator-Induced Lung Injury.” Thematic Poster Session, American Thoracic Society

Annual International Meetings, San Francisco, California, April, 2001.

Moderator: “Biologic Markers of Acute Lung Injury.” American Thoracic Society International Meeting,

Atlanta, Georgia, 2002.

Facilitator, Thematic Poster Session: "Molecular Biology of Critical Care." American Thoracic Society

International Conference, Orlando, Florida, May, 2004.

Session Chair, Scientific Symposium: "Acute Lung Injury: Targeting Coagulation and Fibrinolysis."

American Thoracic Society International Conference, Orlando, Florida, May, 2004.

Facilitator, Thematic Poster Session: "Acute Lung Injury: Mechanisms." American Thoracic Society

International Conference, San Diego, California, May 2005.


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Symposium Chair: Bench to Bedside: Targeting Coagulation and Fibrinolysis in Acute Lung Injury.

Experimental Biology Meeting, San Francisco, California, April, 2006.

Session Chair: Clinical Year in Review Sessions. American Thoracic Society International Conference.

San Francisco, CA, May, 2007.

Session Chair: “ALI/ARDS: Risks and Outcomes”. American Thoracic Society International Conference.

San Francisco, CA, May, 2007.

Session Chair: “Getting Beyond the Starting Line: Determinants of Resolution in Acute Lung Injury.”

American Thoracic Society International Conference. Toronto, Canada, May, 2008.

Session Facilitator: “Acute Lung Injury and ARDS: Biological Mechanisms.” American Thoracic Society

International Conference. American Thoracic Society International Conference. Toronto, Canada, May,

2008.

Session Chair: Clinical Year in Review Sessions. American Thoracic Society International Conference.

San Diego, California, May, 2009.

Facilitator: Thematic Poster Session. “New Insights into Inflammation and Acute Lung Injury”.

American Thoracic Society International Conference. San Diego, California, May, 2009.

Facilitator: Thematic Poster Session. “Omics and Informatics”. American Thoracic Society International

Conference. San Diego, California, May, 2009.

Facilitator: Thematic Poster Session. “Sepsis: Mechanisms and Implications for Management.” American

Thoracic Society International Conference. New Orleans, Louisiana, May, 2010.

Facilitator, Thematic Poster Session. “Mechanical Ventilation.” American Thoracic Society International

Conference. Denver, Colorado, May, 2011.

Session Chair. “Microparticles: Small Wonders or a Big Deal in Pulmonary Injury and Disease.”

American Thoracic Society International Conference. San Francisco, California, May, 2012.

Facilitator, Thematic Poster Session. “New Insights in Acute Lung Injury: In Vivo and In Vitro”. American

Thoracic Society International Conference. San Francisco, California, May, 2012.

Session Chair. “Mechanisms of Lung Regeneration.” American Thoracic Society International

Conference, Philadelphia, Pennsylvania, May 2013.

Meet the Professor Presenter. “How I Do It: Strategies of Successful Women In Critical Care.” American

Thoracic Society International Conference, San Francisco, CA, May 2016.

Facilitator, Thematic Poster Session. “Respiratory Failure: Clinical and Translational Aspects Of VILI

And Lung Protective Mechanical Ventilation.” American Thoracic Society International Conference, San

Francisco, CA, May 2016.

Facilitator, Thematic Poster Session. American Thoracic Society International Conference, “Critical care:

Translational insights into ARDS and sepsis - from bench to bedside,” Washington, DC, May 2017.

EDITORIAL RESPONSIBILITIES

Senior Associate Editor, American Journal of Physiology: Lung Cellular and Molecular Physiology,

2012-2013


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Associate Editor, American Journal of Physiology: Lung Cellular and Molecular Physiology, 2006 - 2011

Editorial Board Memberships:

American Journal of Respiratory and Critical Care Medicine, 2003 - 2008

American Journal of Physiology: Lung Cellular and Molecular Physiology

2003-2005

Biomarker Insights, 2006 - Pres.

Editorial Services:

New England Journal of Medicine Chest

European Respiratory Journal American Journal of Medicine

Journal of Pharmacology and Experimental Therapeutics Intensive Care Medicine

International Journal of Radiation Oncology Biology Physics Journal of Experimental Medicine

Lancet Journal of Cellular Physiology

American Journal of Respiratory and Critical Care Medicine JAMA

Science Translational Medicine Lancet Respiratory Medicine

Critical Care Medicine Journal of Clinical Investigation

American Journal of Respiratory Cell and Molecular Biology Blood

American Journal of Obstetrics and Gynecology American Journal of Transplantation

Journal of Heart and Lung Transplantation Critical Care

Other Editorial Responsibilities:

Guest Editor, Seminars in Respiratory and Critical Care Medicine issue on Acute Lung Injury, 2013.

Guest Editor, Clinics in Chest Medicine issue on Acute Respiratory Distress Syndrome, 2014.

REVIEW RESPONSIBILITIES

NIH Extramural Grant Review:

NIH NHLBI Program Project Grant Review Committee, February, 2002.

NIH NHLBI Program Project Grant Review Committee, May, 2003.

NIH/NHLBI Program Project Grant Review Committee, December, 2006.

NIH/NHLBI Molecular Phenotypes for Lung Diseases Review Committee, August, 2008.

NIH/NHLBI Small Business Respiratory Sciences Special Emphasis Panel, July, 2009.

Co-Chair, NIH/NHLBI Small Business Respiratory Sciences Special Emphasis Panel, November, 2009,

March, 2010.

NIH SAT (Surgery, Anesthesia, Trauma) Study Section Ad Hoc reviewer. January 2010, September 2010,

February 2011.

NIH SAT (Surgery, Anesthesia, Trauma) Permanent Study Section member. 2011 – 2017.

Other Grant Review:

Ad Hoc Reviewer, Health Research Board of Ireland, Clinical Research Training Fellowship Program,


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2000

Ad Hoc Reviewer, Congressionally Directed Peer-Reviewed Medical Research Program (CDMRP),

American Institute of Biological Sciences and U.S. Army Research and Material Command, June 2003

Ad Hoc Reviewer, National Medical Research Council, Singapore, September, 2003

External Reviewer, Respiratory System Committee, Canadian Institute of Health Research, May 2004,

November 2004

External Reviewer, Burroughs Wellcome Fund Research Training Fellowship Program, January 2007.

External Reviewer, Hong Kong University Grants Council, March, 2010.

External Reviewer, Medical Research Council, United Kingdom, August, 2010, April, 2011, November

2013.

External Referee, The Netherlands Organisation for Health Research and Development. January, 2012.

External Reviewer, Swedish Foundation for Strategic Research, August 2014, March 2017.

External Reviewer, UK National Institute for Health Research Efficacy and Mechanism Evaluation

Programme, December 2014.

External Reviewer, French Intensive Care Society Research Grant Program, June 2015.

Programmatic Reviewer, US Army Medical Research and Materiel Command PRMRP Discovery Award

program, 2015.

External Reviewer, Austrian Science Fund, 2017.

GRANT AWARDS

PENDING:

1R01GM122425 (Ware, Janz, Liu) 08/01/17 – 07/31/2022

NIH/NIGMS

“Acetaminophen for Reduction of Organ Dysfunction in Severe Sepsis II (ACROSS II).” This multicenter

prospective randomized clinical trial tests the hypothesis that acetaminophen will reduce oxidant injury and organ

dysfunction compared to placebo in patients with severe sepsis.

CURRENT:

1R01HL135849 (Ware, Bastarache) 07/01/17 – 06/30/2022

NIH/NHLBI

“Targeting cell-free hemoglobin in sepsis to reduce lung microvascular permeability: mechanistic and translational

studies.” This translational project studies the mechanisms of harmful effects of cell-free hemoglobin in mouse

sepsis models, cultured lung microvascular endothelial cells and isolated perfused human lungs.

R01 HL126176-01 (Ware) 12/01/2014 – 11/30/19

NIH/NHLBI

“The GOLD Study: Goal of Open Lung Ventilation in Donors.” This prospective randomized clinical trial will test

the hypothesis that an open lung protective ventilatory strategy will improve oxygenation and donor lung utilization

in 400 brain dead organ donors.


14

5 K24 HL103836 (Ware) 07/09/10 - 03/31/21

NIH/NHLBI

“Midcareer Investigator Award in Patient Oriented Research in Acute Lung Injury.” This award allows Dr. Ware to

build and expand her research and mentoring programs in patient-oriented research in acute lung injury (ALI) and to

devote more time to her current mentees as well as to expand her mentoring to include new postdoctoral trainees as

well as medical students in the research immersion phase of their training.

1 R01 HL 111111-01A1 (Pandharipande) 08/15/12 – 06/30/17

NIH/NHLBI

“Altering Sedation Paradigms to Improve Brain Injury and Survival in Severe Sepsis.” This study tests the

hypotheses that sedation of mechanically ventilated septic patients with an alpha2 agonist (dexmedetomidine) rather

than a GABAergic agent (propofol) will increase days alive without delirium or coma, improve 90-day survival,

decrease long-term cognitive impairment, and reduce the pro-inflammatory cytokine cascade following sepsis.

R01 HL 087115-06A1 (Christie) 07/01/14 – 6/30/18

NIH/NHLBI

“Clinical Risk Factors for Primary Graft Dysfunction.” Dr. Ware leads the biomarker development and validation

aspects of this project. This is a multicenter cohort study of lung transplant recipients investigating the role of donor

smoking as a risk factor for acute lung injury (primary graft dysfunction) following lung transplantation.

COMPLETED:

5 R01 HL 088263 (Ware) 02/01/08 - 01/31/15

NIH/NHLBI

“Treatment of Pulmonary Edema in Organ Donors.” Dr. Ware designed and implemented this multicenter clinical

trial. This project tested the hypothesis that administration of an aerosolized beta-2 agonist (albuterol) in a

randomized, blinded placebo controlled trial in 500 brain dead organ donors will improve donor oxygenation by

enhancing clearance of pulmonary edema and will improve donor lung procurement rates.

1 R01 HL 108712-01 (Ware) 09/01/12 – 08/31/14

NIH/NHLBI – Mayo Clinic Subcontract

“LIPS-A: Lung Injury Prevention Study with Aspirin.” This proect was a multicenter, phase II, double-blind,

placebo-controlled, randomized clinical trial of aspirin for the prevention of ALI. Dr. Ware’s laboratory served as

the biomarker core for this clinical trial.

NIH P30 ES000267 (Liebler) 10/1/13 – 9/30/14

Center for Molecular Toxicology Pilot Project Grant

“Air Pollutants and Risk of Acute Respiratory Distress Syndrome.” This study tests the hypothesis that exposure to

high levels of common air pollutants including ozone and particulate matter causes lung inflammation and oxidative

stress, priming the lung to develop ARDS in the setting of an appropriate clinical risk factor.

5 R21 HL 112656 (Ware) 05/04/12 - 04/30/15

NIH/NHLBI

“Inflammatory and Epithelial Injury Markers for ARDS Prognosis: A Validation Study.” This study is designed to

test the hypothesis that biomarkers of inflammation and lung epithelial injury can be validated to serve as prognostic

indicators in patients with acute lung injury.

AHA Established Investigator Award 01/01/09 - 12/31/13

American Heart Association

“Coagulation and Fibrinolysis in Ventilator Associated Lung Injury: The Role of Alveolar Epithelium.” The overall

hypothesis for this proposal was that cyclic mechanical stretch of the alveolar epithelium potentiates pro-

inflammatory intra-alveolar fibrin deposition.

2 R01 HL 055330-15A1 (Choi) 06/01/13 – 05/31/14

NIH/ (subcontract Brigham & Women’s)


15

“Inflammasomes: Regulation and Function in Acute Lung Injury.” Specific Aim #1: To determine the regulation

and function of inflammasome complex formation and its regulated pro-inflammatory cytokines in experimental

ALI. Specific Aim #2: To determine the mechanism(s) by which cytoprotective CO molecule inhibits

inflammasome complex and its downstream pro-inflammatory cytokines in experimental ALI Specific. Aim #3: To

determine whether inflammasome complexes and/or its regulated pro-inflammatory cytokines can serve as

biomarkers to predict disease severity and mortality in human

NIH - 1 K08 HL 090785-01A1 (Bastarache) 01/01/09 - 12/31/13

NIH/NHLBI

“Tissue Factor Mediated Fibrin Deposition in Acute Lung Injury.” Under the guidance of Dr. Lorraine Ware

(mentor), Dr. Bastarache tested the hypothesis: Alveolar epithelial upregulation and release of active tissue factor in

response to inflammatory and apoptotic stimuli is necessary for intra-alveolar fibrin deposition and is a key

determinate of physiologic and histologic extent of acute lung injury and the acute respiratory distress syndrome.

5 U01 DK 082192-05 (Ikizler) 12/01/09 - 06/30/13

NIH/NIDDK

“Impact of Acute Kidney Injury on Kidney Disease Progression.” This project established an Acute Kidney Injury

(AKI) Natural History Consortium with the primary objective of following the natural history of patients with AKI

after they finish the acute phase of their illness for comparison with concurrent relevant control patients. AKI is a

common and serious complication in hospitalized patients.

5 R01 HL 081619-02 (Christie) 02/01/08 – 01/31/12

NIH/NHLBI

“Genetics of Primary Graft Dysfunction.” Primary graft dysfunction (PGD) is severe acute lung injury occurring in

the days after lung transplantation, characterized by diffuse pulmonary edema and profound hypoxemia. This study

expanded an established multicenter cohort study infrastructure, including prospective clinical data collection and

sequential blood collection, to determine the association of candidate oxidant stress regulatory genes in donors and

recipients with development of PGD.

1 R01 AG 027472-01A1 (Ely) 9/01/06 – 06/30/11

NIH

"The MIND ICU Study." Dr. Ware was responsible for designing and implementing all the proposed studies of

biomarkers of delerium and long term cognitive dysfunction in this large multi-center observational study. This

study examined whether duration of delirium is an independent risk factor for the incidence, severity and/or duration

of long-term cognitive impairment and impaired health-related quality of life in ICU survivors.

1 U01 HL 081332-01 (Ware) 08/12/05 – 06/30/09

NIH/NHLBI

"Biomarker Profiles in the Diagnosis/Prognosis of ARDS." Dr. Ware directed this multidisciplinary Vanderbilt

Clinical Proteomics Program, one of four NHLBI sponsored Clinical Proteomics Programs.

NIH K08 HL 70521 (Ware) 09/01/2001 – 08/31/2006

NIH/NHLBI

“Alveolar Epithelium in Acute Lung Injury.” The overall goal of the proposal was to study the mechanisms that

regulate alveolar fluid clearance in ALI/ARDS.

Biomedical Research Grant (Ware) 7/1/2005 –6/31/2007

American Lung Association

"Alveolar Epithelial Modulation of Intra-Alveolar Coagulation in ARDS." The overall objective of this project was

to investigate the hypothesis that the alveolar epithelium actively modulates intra-alveolar coagulation and

fibrinolysis, an important factor in the pathogenesis and resolution of acute lung injury

INVITED LECTURES:

Intramural:


16

Vanderbilt Pulmonary/Critical Care Gordon Conference: "Alveolar Fluid in ARDS: Overcoming Problems in

Translational Research," September 2002.

Vanderbilt Pulmonary Research Seminar: "Alveolar Epithelial Fluid Transport and Lung Transplantation.

Evaluation of Donor Lungs and Patients with Reperfusion Pulmonary Edema," March 2003.

Series Editor, Core Lecture Series, “Environmental Medicine,” Allergy, Pulmonary and Critical Care Medicine,

August-September, 2003.

Lecturer, “The Pulmonary Physiology of SCUBA Diving,” Environmental Medicine Core Lecture Series, Allergy,

Pulmonary and Critical Care Medicine, August 13, 2003.

Medical Grand Rounds, "The Role of the Alveolar Epithelium in the Pathogenesis and Resolution of ARDS,"

Vanderbilt University Department of Medicine, March 2004.

Cardiovascular and Thoracic Surgery Grand Rounds, "The Role of Alveolar Epithelial Fluid Transport in Lung

Transplantation," Vanderbilt University Department of Thoracic Surgery, August, 2004.

Vanderbilt Pulmonary Critical Care Gordon Conference, "Clinical Proteomics in Acute Lung Injury," June 2004.

Vanderbilt Pulmonary Critical Care Gordon Conference, "Increasing Donor Lung Utilization Rates: Is There a Role

for New Donor Management Strategies?" November, 2004.

Vanderbilt Department of Medicine Housestaff Conference, "ARDS--The Basics," January 2005.

Vanderbilt Pulmonary Research Conference, "Regulation of Intra-Alveolar Coagulation Under Pathological

Conditions: Role of the Alveolar Epithelium," September 2002.

Series Editor, Core Lecture Series, "Acute Lung Injury," Division of Allergy, Pulmonary, and Critical Care

Medicine, September-October, 2005.

Lecturer, "Diving Physiology," Division of Allergy, Pulmonary, and Critical Care Medicine, September 2005.

Speaker, "Biomarker Profiles in Acute Lung Injury/ARDS, "Vanderbilt Pulmonary Critical Care Friday Noon

Conference, November, 2005.

Lecturer, "Biomarker Profiles in Acute Lung Injury," MSCI Program Case Studies Lecture, Vanderbilt Clinical

Proteomics Program, November, 2005.

Invited Speaker: “Pulmonary edema in organ donors and ARDS patients: Opportunities to integrate proteomic and

genetic studies.” Vanderbilt Center for Human Genetics Research. Genetics Interest Group Seminar. Nov., 2006.

Speaker, Pulmonary Core Lecture Series. “Acute Respiratory Distress Syndrome.” February, 2007.

Chair and Invited Speaker. Vanderbilt Biomarker Summit “Biomarkers for Diagnosis and Prognosis in Acute Lung

Injury.” June, 2007.

Lecturer, “Physiology of SCUBA Diving”, Division of Allergy Pulmonary and Critical Care Medicine, Aug., 2007.

Lecturer, “Severe Acute Pancreatitis”, Division of Allergy Pulmonary and Critical Care Medicine, September. 2007.

Speaker, “Research Profile”, Division of Allergy, Pulmonary and Critical Care Medicine, Gordon Conference.

February, 2008.

Lecturer, “ARDS”, Pulmonary Core Lecture Series. August, 2008.


17

Speaker, Pulmonary Grand Rounds. “Extravascular Fibrin Deposition in ARDS – Basic Mechanisms and Clinical

Significance.” October, 2008.

Speaker, Pulmonary/Critical Care Gordon Conference. “The BOLD Study. Update on a Randomized Clinical Trial

of Nebulized Albuterol in Organ Donors.” October, 2008.

Lecturer, “Acute Pancreatitis”, Pulmonary Core Lecture Series, August, 2009.

Lecturer, “Diving Physiology”, Pulmonary Core Lecture Series, October, 2009.

Invited Speaker, Molecular Physiology and Biophysics Research Seminar Series, “The alveolar epithelium – Key

regulator of alveolar fibrin deposition?” October, 2009.

Vanderbilt Pulmonary Critical Care Gordon Conference. “Biomarkers of Acute Lung Injury: Pathways to

Pathogenesis?” April, 2010.

Vanderbilt Infectious Disease Grand Rounds. “What’s New in Sepsis? Biomarkers, Pathophysiology and Novel

Therapies.” April, 2010.

Lecturer, “ARDS”, Pulmonary and Critical Care Core Curriculum. September, 2010.

Vanderbilt Pulmonary Grand Rounds. “Acute Lung Injury: Insights into genetic and environmental risk factors from

the VALID Study.” December, 2010.

Department of Medicine Research Council. “Atrial fibrillation and critical illness.” May, 2011.

Lecturer, “Severe Acute Pancreatitis”, Pulmonary Core Lecture Series. August, 2011

Lecturer, “Diving Physiology”, Pulmonary Core Lecture Series, September, 2011.

Women on Track Invited Speaker. “Collaboration in Translational Research”. October, 2011.

Speaker, Pulmonary Grand Rounds. “Results of the BOLD Study: Beta-agonists for Oxygenation in Lung Donors”.

November, 2011.

Speaker, Pathology, Microbiology and Immunology Grand Rounds. “Fibrin Deposition in Acute Lung Injury:

Necessary or Necessary Evil?” February, 2012.

Lecturer, “ARDS.” Anesthesia Critical Care Conference. October, 2012.

Lecturer, “ARDS” Pulmonary Fellowship Core Curriculum. October, 2012

Speaker, Pulmonary/Critical Care Gordon Conference. “The Gold Study: Goal of Open Lung Ventilation in

Donors.” April, 2013.

Invited Speaker, Vanderbilt Elliot Newman Society. “Establishing Effective Collaborations.” May, 2013.

Lecturer, “Severe Acute Pancreatitis”, Pulmonary Core Lecture Series. November, 2013

Lecturer, “Diving Physiology”, Pulmonary Core Lecture Series, November, 2013.

Lecturer, “ARDS: What’s New in 2013?” Anesthesia Critical Care Conference. November, 2013.

Invited Speaker, Pulmonary Grand Rounds. “Thinking outside the cell: Cell-free hemoglobin in sepsis and acute

lung injury”, April 2014.


18

Lecturer, “ARDS.” Pulmonary Fellowship Core Curriculum. September 2014.

Invited Speaker, Pulmonary Grand Rounds. “Something in the air? Exposure to air pollutants and risk of ARDS”,

February 2015.

Lecturer, “Update in ARDS post Berlin: Diagnostic criteria, biomarkers and current challenges” Anesthesia

Critical Care Conference. March, 2015.

Lecturer, “Diving Physiology”, Pulmonary Core Lecture Series, September, 2015.

Lecturer, “Severe Acute Pancreatitis”, Pulmonary Core Lecture Series, January 2016.

Vanderbilt Program in Molecular Medicine, “Seeing red: Free Hemoglobin and the Pathogenesis of Sepsis-induced

ARDS.” January, 2016.

Vanderbilt Acute Kidney Injury Club, “Cell-Free Hemoglobin and Acute Kidney Injury in Sepsis.” February, 2016.

Speaker, Pulmonary Grand Rounds, “Red Rover, Red Rover send hemoglobin over: How cell-free hemoglobin

injures the endothelial barrier in sepsis”. November, 2016.

Lecuture, “Acute Respiratory Distress Syndrome”, Pulmonary Core Lecture Series, November 2016.

National:

Invited Speaker: "From CMC to the ICU. Reflections on Becoming a Doctor." Women in Medicine Series, Marion

Miner Cook Athenaeum, Claremont McKenna College, Claremont, California, 1997.

Invited Speaker, BRIDGE Lecture: “Resolution of Pulmonary Edema.” Department of Medicine, University of

California at San Francisco, 1998.

Invited Speaker: “Alveolar Epithelial Fluid Transport in Patients with Acute Lung Injury: The Value of Multiple

Sequential Pulmonary Edema Fluid Samples.” American Thoracic Society, Chicago, Illinois, 1998.

Invited Speaker: “Clinical Significance of Endothelial and Epithelial Markers in Pulmonary Edema Fluid of Patients

with Acute Lung Injury.” American Thoracic Society, Chicago, Illinois, 1998.

Invited Speaker: “Keratinocyte Growth Factor Increases Alveolar Epithelial Wound Healing In Vitro.” Experimental

Biology Meeting, San Francisco, California, 1998.

Invited Speaker “Elevated pulmonary edema fluid concentrations of sICAM-1, a biological marker of both

endothelial and epithelial injury, identify patients with acute lung injury who have impaired alveolar epithelial fluid

transport and more severe acute respiratory failure.” Aspen Lung Conference on Acute Lung Injury, Aspen,

Colorado, 1998.

Invited Speaker: “Maximal Alveolar Epithelial Fluid Clearance in Clinical Acute Lung Injury: An Excellent

Predictor of Survival and the Duration of Mechanical Ventilation.” American Thoracic Society, San Diego,

California, 1999.

Invited Speaker: “Results of the NIH ARDS Network Trial of Low Tidal Volume Ventilation for ARDS.” Cedars

Sinai Hospital, Los Angeles, California, 2000.

Visiting Professor: “What Can We Learn from Pulmonary Edema Fluid?” University of Alabama in Birmingham,

Birmingham, Alabama, 2001.

Visiting Professor: “Alveolar Fluid Transport in Acute Lung Injury and Hydrostatic Pulmonary Edema.” Case

Western Reserve University, Cleveland, Ohio, 2001.


19

Invited Speaker: “Evaluation of Lungs Rejected for Transplantation.” California Transplant Donor Network Donor

Management Meeting, Millbrae, California, 2001.

Visiting Professor: “What Can We Learn from Pulmonary Edema Fluid?” University of California at Los Angeles,

Los Angeles, California, 2001.

Visiting Professor: “Determinants of Alveolar Fluid Clearance in Hydrostatic Edema and Acute Lung Injury,”

Vanderbilt University, Nashville, Tennessee, 2002.

Invited Speaker: “Enhanced alveolar epithelial repair may contribute to the protective effect of keratinocyte growth

factor (KGF) in ventilator induced lung injury (VILI).” Experimental Biology Meeting, New Orleans, Louisiana,

2002.

Invited Speaker: "Evaluation of Donor Lungs that are Rejected for Transplantation. Are We Wasting Good Lungs?"

Issues in Transplantation and Organ Procurement, Tennessee Donor Services, Nashville, Tennessee, May 2003.

Visiting Professor: "Modulation of Intra-Alveolar Coagulation and Fibrinolysis by the Alveolar Epithelium."

Cardiovascular Research Institute, University of California, San Francisco, December, 2003.

Invited Speaker: "Non-invasive Measures for Determining the Etiology of Acute Pulmonary Edema." Postgraduate

Seminar: Pulmonary Edema: Forms, Physiology and Management. American Thoracic Society International

Conference, Orlando, Florida, May, 2004.

Invited Speaker: "Human Studies of Coagulation and Fibrinolysis Factors in ARDS." American Thoracic Society

International Conference, Orlando, Florida, May, 2004.

Invited Speaker: "Alterations in Coagulation and Fibrinolysis in ARDS." Pulmonary and Critical Care Grand

Rounds, Memorial Sloane Kettering Hospital, New York, New York, April, 2005.

Invited Speaker and Participant: "Proteomics in acute lung injury." NIH NHLBI Working Group: The Next Step:

Population Studies in the "-OMIC" age. Bethesda, Maryland, June 2005.

Invited Speaker: "Biomarkers in Acute Lung Injury - Combined SCCOR Project”. Annual Acute Lung Injury

SCCOR Meeting, San Francisco, California, September, 2005.

Invited Speaker: "Update on Biomarker Profiles in ALI/ARDS." Clinical Proteomics Programs Investigators

Meeting, NIH NHLBI, Washington, D.C., March, 2006.

Invited Speaker: "Coagulation and Fibrinolysis in Clinical ARDS--New Therapeutic Target?" Experimental Biology

Meeting, San Francisco, California, April, 2006.

Invited Speaker: “Biomarker profiles in acute lung injury. Studies in the ALVEOLI database.” Annual Acute Lung

Injury SCCOR Meeting, Baltimore, MD September, 2006.

Invited Speaker: “Proteomic analysis of plasma in ARDS.” 2006 American Physiological Society Conference:

Physiological Genomics and Proteomics of Lung Disease”, Ft. Lauderdale, FL, November, 2006.

Invited Speaker: “Protein profiles in the diagnosis and prognosis of acute respiratory distress syndrome.” 2006

American Heart Association session “Cardiovascular Proteomics: Ready for the clinic?” Chicago, IL, November,

2006.

Visiting Professor: “Fibrin Deposition in the Acutely Injured Lung – Role of the Alveolar Epithelium”.

Northeastern Ohio University Department of Physiology. May, 2007.

Invited Speaker: “Proteomic Approaches for Biomarker Discovery”. American Thoracic Society Postgraduate


20

Course. Tools of the Trade for Translational Research. San Francisco, CA, May, 2007.

Session Chair and Invited Speaker: “Mining the Proteome for Biomarkers in Lung and Heart Disease: Update from

the NHLBI Clinical Proteomics Programs”. American Thoracic Society International Conference. San Francisco,

CA, May, 2007.

Invited Speaker: “Measuring extravascular lung water in ARDS”. American Thoracic Society International

Conference. San Francisco, CA, May, 2007.

Invited Speaker: “Combining Clinical and Biochemical Indices Improves Prediction of Outcomes in Acute Lung

Injury”. American Thoracic Society International Conference. San Francisco, CA, May, 2007.

Invited Speaker: “Modulation of Intra-Alveolar Fibrin Deposition by the Alveolar Epithelium in Acute Lung Injury”.

Aspen Lung Conference on Lung Injury and Repair, Aspen, CO, June, 2007.

Visiting Professor: “Inflammatory coagulopathy in ARDS: Role of the Alveolar Epithelium”. Pulmonary and

Critical Care Division, University of Washington, Seattle, WA, August, 2007.

Invited Speaker and Session Moderator: “Vanderbilt Clinical Proteomics Program in Acute Lung Injury”.

Proteomic Technologies: Current State and Challenges for the Future. Chevy Chase, MD, September, 2007.

Faculty and Invited Speaker: “Use of Specific Biologic Markers as Indicators or Prognostic Markers of Various

Levels of Sepsis”. American College of Chest Physicians, CHEST 2007, Chicago, IL, October, 2007.

Invited Speaker: “Update on Biomarker Profiles for Diagnosis and Prognosis in ALI/ARDS”. NHLBI Clinical

Proteomics Programs Steering Committee Meeting, Rochester, MN, October, 2007.

Invited Speaker and Faculty: “Markers of Lung Injury”. Biomarkers of Cardiovascular Risk: State of the Art. Mayo

Clinic, Rochester, MN, October, 2007.

Invited Speaker: “Challenges in Bringing Proteomics to the Clinic: Experiences in ARDS”. American Heart

Association Scientific Sessions, Orlando, FL, November, 2007.

Visiting Professor: “Strategies to Improve Donor Lung Function: The Role of Alveolar Fluid Clearance.”

University of Tennessee at Memphis, Department of Physiology, Memphis, Tennessee, January, 2008

Visiting Professor: “Extravascular fibrin deposition in ARDS – Basic mechanisms and clinical significance.”

Brigham and Women’s Hospital, Pulmonary and Critical Care Medicine, Boston, Massachusetts, February, 2007.

Invited Speaker: “Vanderbilt Clinical Proteomics Program in ARDS”. NHLBI Clinical Proteomics Program

External Advisory Panel Meeting. Bethesda, MD, February 2008.

Invited Speaker: “Current Evidence-Based practices in managing ALI/ARDS.” Experimental Biology Meeting, San

Diego, California, April, 2008.

Invited Speaker: “Genomics and proteomics of acute lung injury”. FASEB Summer Research Conference, “The

Lung Epithelium in Development and Disease”. Saxton’s River, Vermont, August, 2008.

Invited Speaker, Medical Grand Rounds: “The lung epithelium in ARDS: Therapeutic target?” University of Texas,

Tyler Texas, December, 2008.

Visiting Professor: “ARDS: What’s new in diagnosis and treatment.” University of Pennsylvania, Division of

Pulmonary, Allergy and Critical Care, Philadelphia, Pennsylvania, February, 2009.

Invited Speaker: “Update on the Vanderbilt Clinical Proteomics Program in Acute Lung Injury.” NHLBI Clinical

Proteomics Program External Advisory Panel Meeting. San Diego, California, February, 2009.


21

Invited Speaker: “Lung Biomarkers: Adventures in Multiplex Validation”. Special Joint NHLBI Proteomics Open

Session, “Translating Proteomics into Biomarkers for Heart and Lung Diseases”, US HUPO Meeting, San Diego,

California, February, 2009.

Visiting Professor: “Fibrin Deposition in the Acutely Injured Lung: Role of the Alveolar Epithelium.” Institute of

Environmental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, February, 2009.

Invited Speaker: “Proteomics. Ready for Prime Time?” American Thoracic Society International Conference

Postgraduate Course, “A Genomics Toolbox”. San Diego, California, May, 2009.

Visiting Professor: “Regulation of intra-alveolar fibrin deposition in acute lung injury – A new role for the alveolar

epithelium?” University of Iowa, Pulmonary Division, Iowa City, Iowa, December, 2009.

Invited Speaker. “Biomarker Profiles in ALI/ARDS.” American Thoracic Society International Conference,

Molecular Markers at the Bedside Session. New Orleans, Louisiana, May, 2010.

Invited Speaker. “Proteomic Analysis of Pulmonary Edema Fluid from Patients with ALI/ARDS Reveals a

Prominence of Intracellular Proteins.” Aspen Lung Conference, Systems Biology of Lung Diseases – Progress in the

“Omics” Era. Aspen, Colorado, June, 2010.

Invited Speaker. “Biomarkers for ARDS” in “Biomarkers in Clinical Research” Session. Society of Critical Care

Medicine Congress. San Diego, California, January, 2011.

Visiting Professor. “Biomarkers and beyond: Diagnostic and prognostic predictors in clinical acute lung injury.”

University of Colorado, Pediatric and Adult Critical Care, Denver, Colorado, April, 2011.

Visiting Professor. “A confluence of cascades: How inflammation and coagulation interact with the lung epithelium

to modulate fibrin deposition in acute lung injury.” University of Colorado, Pediatric and Adult Critical Care,

Denver, Colorado, April, 2011.

Invited Speaker. “Restoring the Balance Between Alveolar Fibrin Deposition and Fibrinolysis. Translational

Studies of the Alveolar Epithelium.” American Thoracic Society International Conference. Denver, Colorado, May,

2011.

Invited Speaker/Career Expert, Investigator Pathway. Center for Fellows and Junior Professionals. American

Thoracic Society International Conference. Denver, Colorado, May, 2011.

Visiting Professor. “A confluence of cascades. How the lung epithelium modulates fibrin deposition in acute lung

injury.” Department of Anesthesia, University of Alabama, Birmingham, Alabama, June 2011.

Visiting Professor. “Fibrin deposition in acute lung injury: Necessary or necessary evil?” Department of

Pharmacology, University of Illinois, Chicago, Illinois. October, 2011.

Visiting Professor. “ARDS: New insights in risk prediction, diagnosis and prognosis.” Pulmonary and Critical Care

Medicine, University of Illinois, Chicago, Illinois, October, 2011.

Visiting Professor. “Results of the Beta-Agonists for Oxygenation in Lung Donors Trial.” Cardiovascular Research

Institute, University of California, San Francisco, California. January, 2012.

Visiting Professor. “Fibrin deposition in acute lung injury: Necessary or necessary evil?” Division of Pulmonary

and Critical Care Medicine, University of California, San Francisco, California, January, 2012.

Plenary Speaker. “Clinical Year in Review: ARDS”. American Thoracic Society International Conference, San

Francisco, California, May, 2012.


22

Invited Speaker. “Incomplete Journeys in Drug Discovery and Development – Acute Lung Injury and Sepsis”

American Thoracic Society International Conference, San Francisco, California, May, 2012.

Invited Speaker and Organizing Committee. “ARDS. Biomarker Phenotype”. Pittsburgh International Lung

Conference, Pittsburgh, Pennsylvania, October, 2012.

Invited Speaker. “New developments in the diagnosis and treatment of ARDS.” Department of Medicine Grand

Rounds. University of South Alabama Medical Center, Mobile, Alabama, April, 2013.

Distinguished Scientist Seminar. “Cell-Free hemoglobin and the pathogenesis of acute lung injury: A tale of bad

blood?” Lung Biology Center, University of South Alabama, Mobile, Alabama, April, 2013.

Moderator, Poster Discussion Session. “Acute Respiratory Distress Syndrome. Risk Factors, Biomarkers and a

New Definition.” American Thoracic Society International Conference, Philadelphia, Pennsylvania, May 2013.

Invited Speaker. “The Gold Study: Goal of Open Lung Ventilation in Donors.” California Transplant Donor

Network Thoracic Affairs Committee Meeting, San Francisco, California, May, 2013.

Invited Speaker. “Hemolysis in ARDS.” American Thoracic Society International Conference, San Diego,

California, May 2014.

Invited Speaker. “Oxidative injury due to cell-free hemoglobin in sepsis and ARDS: Results of a randomized

clinical trial of acetaminophen.” Aspen Lung Conference, Aspen, Colorado, June 2014.

Invited Speaker. “Acute Respiratory Distress Syndrome: Current Issues in Diagnosis, Prognosis and Therapy.”

Global Blood Therapeutics, South San Francisco. July 2014.

Invited Speaker. “Long-Term Ozone Exposure Levels are Associated with Development of Acute Respiratory

Distress Syndrome (ARDS) in Critically Ill Patients.” American Thoracic Society International Conference.

Denver, Colorado, May 2015.

Recognition for Scientific Accomplishments Award Lecture. “Seeing Red: Free Hemoglobin and the Pathogenesis

of Sepsis and ARDS.” American Thoracic Society International Conference. Denver, Colorado, May 2015.

Visiting Professor. “Seeing Red: Free Hemoglobin and the Pathogenesis of Sepsis and ARDS”. Brown

University/Rhode Island Hospital COBRE program, Providence, Rhode Island, November 2015.

Visiting Professor. “Seeing Red. Cell-free hemoglobin is a mediator of sepsis-induced organ dysfunction and acute

lung injury.” University of Chicago, Chicago, IL, February 2016.

Special Lecturer. “Cell Free Hemoglobin: Role in ARDS and Other Organ Dysfunction.” 33rd

Annual Conference

on High Frequency Ventilation of Infants, Children and Adults. Snowbird, Utah, March 2016.

Visiting Professor. “Seeing Red: Cell-free hemoglobin mediated organ dysfunction in sepsis and ARDS.” University

of Utah, Salt Lake City, UT, April 2016.

Invited Speaker. “Long-term Exposure to Ozone and the Risk of ARDS in Critically Ill Patients.” 2nd

Annual

Vanderbilt-UAB Pulmonary Research Summit. Birmingham, AL, June 2016.

Visiting Professor. “Seeing red: Cell-free hemoglobin mediated organ dysfunction in sepsis and ARDS”. Ohio

State University Wexner Medical Center. Columbus, OH, March 2017.

Invited Speaker. “Molecular phenotyping to reduce heterogeneity in ARDS.” Shock Society Annual Meeting, Fort

Lauderdale, FL, June 2017.


23

International:

Invited Speaker: “Criteria for Transplantation of Donor Lungs Should be Reevaluated.” 4th International Congress

on Lung Transplantation, Paris, France, 2000.

Visiting Professor: "Resolution of Acute Lung Injury and Hydrostatic Pulmonary Edema.” Hospital Henri Mondor,

Creteil, France, 2000.

Invited Speaker: “Biomarkers of Acute Lung Injury.” NATO Conference on Acute Lung Injury, Corfu, 2000.

Invited Speaker: “Nitrate Levels and Nitrated Surfactant Proteins in the Epithelial Lining Fluid of Patients with

Acute Lung Injury.” NATO Conference on Acute Lung Injury, Corfu, Greece, 2000.

Invited Speaker: “Identification of Nitrated Surfactant Protein-A in Pulmonary Edema Fluid from Acute Lung Injury

Patients.” American Thoracic Society, Toronto, Canada, 2000.

Invited Speaker: “Alveolar Epithelial Fluid Transport is Preserved in Human Lungs Rejected for Transplantation.”

American Thoracic Society, Toronto, Canada, 2000.

Invited Speaker: "Importance of Alveolar Fluid Clearance for Survival and Morbidity in the Intensive Care Unit."

30th Annual Meeting of the Society for Neonatology and Pediatric Intensive Care Medicine, Ulm, Germany, 2004.

Invited Speaker: "High prevalence of pulmonary arterial thrombi in donor lungs rejected for transplantation:

implications for lung dysfunction in donor lungs and lung recipients." Sixth International Congress on Lung

Transplantation, Paris, France, 2004.

Plenary Speaker: "Alterations in coagulation and fibrinolysis in ARDS." 9th Acute Lung Injury Conference, Tokyo,

Japan, February, 2005.

Invited Speaker: "Alterations in coagulation and fibrinolysis in ARDS." Keio Igakukai. Keio University School of

Medicine, Tokyo, Japan, February, 2005.

Invited Speaker: "Alterations in coagulation and fibrinolysis in ARDS." Tochigi Respiratory Conference. Dokkyo

University School of Medicine, Utsonomiya, Japan, February, 2005.

Faculty: 26th International Symposium on Intensive Care and Emergency Medicine, Brussels, March 2006.

Invited Speaker: "Hemodynamic vs. non-hemodynamic pulmonary edema." 26th International Symposium on

Intensive Care and Emergency Medicine, Brussels, Belgium, March 2006.

Invited Speaker: "Role for beta-adrenergic agonists in the treatment of ALI/ARDS." 26th International Symposium

on Intensive Care and Emergency Medicine, Brussels, Belgium, March 2006.

Invited Speaker: “Modulation of coagulation and fibrinolysis by the alveolar epithelium.” 26th International

Symposium on Intensive Care and Emergency Medicine, Brussels, Belgium, March 2006.

Session Chair: Clinical Year in Review Sessions. American Thoracic Society International Conference. Toronto,

Canada, May, 2008.

Session Chair and Invited Speaker: “Proteomic approached to Lung and Heart Disease: Update from the NHLBI

Clinical Proteomics Programs”. American Thoracic Society International Conference. Toronto, May, 2008.

Plenary Speaker: “Clinical Year in Review: ARDS”. American Thoracic Society International Conference.

Toronto, Canada, May, 2008.

Invited Speaker: “Coagulation, fibrinolysis and the transition to recovery.” American Thoracic Society International


24

Conference. Toronto, Canada, May, 2008.

Invited Speaker: “Pulmonary edema in organ donors: Comparison of chest radiograph scoring to lung weight as a

quantitative index of lung water.” International Society of Heart and Lung Transplantation, Paris, France, April

2009.

Visiting Professor: “Mechanisms of Fibrin Deposition in Acute Lung Injury.” London Health Sciences Center,

University of Western Ontario, London, Ontario, Canada, June 2009.

Invited Speaker: “Biomarkers of ALI/ARDS in the 21st Century: Pathways to pathogenesis?” Le Syndrome de

Detresse Respiratoire Aigue: Physiopathologie et Nouveau Traitements. Paris, France, April, 2010.

Invited Speaker: “Ventilator Strategies and Inhaled Therapies to Increase Donor Lung Yield”. International Society

of Heart and Lung Transplantation Annual Meeting, Prague Czech Republic, April, 2012.

Invited Speaker: “A Randomized Trial of Nebulized Albuterol to Enhance Resolution of Pulmonary Edema in 506

Brain Dead Organ Donors”. International Society of Heart and Lung Transplantation Annual Meeting. Prague,

Czech Republic, April, 2012.

Invited Speaker: “Free Hemoglobin in Acute Lung Injury: Bystander or Instigator?” International Conference on

Acute Lung Injury: Pathogenesis and Treatment. London, United Kingdom, June, 2012.

Invited Speaker: “Donor Smoking is Associated with Increased Pulmonary Edema and Lower Rates of Alveolar

Fluid Clearance in the Ex Vivo Donor Lung.” 10th

International Congress on Lung Transplantation. Paris, France.

September, 2012.

Visiting Professor. “Searching for New Therapeutic Targets in ARDS”. Inter-departmental Critical Care Medicine

City Wide Grand Rounds. University of Toronto, Toronto, Canada. November, 2012.

Invited Speaker. “Prognostic Markers and Clinical Endpoints”. Scientific Expert Symposium: ARDS. Boehringer

Ingleheim, Biberach, Germany. April, 2013.

Invited Speaker: “Plasma Free Hemoglobin Potentiates the Association between Reperfusion FiO2 and Primary

Graft Dysfunction after Lung Transplantation”. International Society of Heart and Lung Transplantation Annual

Meeting. Montreal, Canada. April, 2013.

Invited Speaker. “Biomarkers for Diagnosis, Prognosis and Clinical Trial Design in ARDS.” 18th

Congress of the

Asian Pacific Society of Respirology. Yokohama, Japan.

November, 2013.

Invited Speaker. “Resolution of ARDS: Future Directions of Treatment.” Deutsche Anästhesiecongress 2014.

Leipzig, Germany. May 2014.

Invited Speaker. “Optimization Options for Lung Donor Organs: In the Donor.” World Transplant Congress. San

Francisco, California. July 2014.

Invited Speaker. “Radiographic atelectasis is a major cause of donor hypoxemia and decreased lung utilization:

findings from the BOLD study.” 11th

International Congress on Lung Transplantation. Paris, France. September,

2014.

Invited Speaker and Co-Chair. “Something in the Air? Exposure to Air Pollutants and Risk of ARDS.” 3rd

International ARDS Conference. Belfast, Northern Ireland. August, 2015.

Invited Speaker. “Cell-Free Hemoglobin: A New Therapeutic Target for Prevention Of Primary Graft Dysfunction?”

12th

International Congress on Lung Transplantation. Paris, France. September, 2016.


25

Invited Speaker. “Circulating Cell-Free Hemoglobin Causes Acute Lung Injury and Increases Mortality in Murine

Polymicrobial Sepsis.” International Federation of Shock Societies, Tokyo, Japan. October, 2016.

Invited Speaker and Conference Co-Chair. “Radiographic Assessment of Lung Edema.” 4th

International ARDS

Conference. Paris, France. June 2017.

BIBLIOGRAPHY

Original Investigations:

1. Ware, L.B., Golden, J.A., Finkbeiner, W.E., Matthay, M.A. Alveolar epithelial fluid transport capacity in

reperfusion lung injury after lung transplantation. Am. J. Respir. Crit. Care Med. 159: 980-988, 1999.

2. Wang, Y, Folkesson, H.G., Jayr, C., Ware, L.B., Matthay, M.A. Alveolar epithelial fluid transport can be

simultaneously upregulated by both KGF and beta-agonist therapy. J. Appl. Physiol. 87: 1852-1860, 1999.

3. Verghese, G.M., Ware, L.B., Matthay, B.A., Matthay, M.A. Alveolar epithelial fluid transport and the

resolution of clinically severe hydrostatic pulmonary edema. J. Appl. Physiol. 87:1301-1312, 1999.

4. Conner, E.R., Ware, L.B., Modin, G., Matthay, M.A.. Elevated pulmonary edema fluid concentrations of

soluble intercellular adhesion molecule-1 in patients with acute lung injury: Biological and clinical

significance. Chest 116: 83S-84S, 1999.

5. Zhu, S., Ware, L.B., Geiser, T., Matthay, M.A., Matalon, S. Increased levels of nitrate and nitrated surfactant

protein-A in the edema fluid of patients with acute lung injury. Am. J. Respir. Crit. Care Med. 163:166-172,

2001.

6. Geiser, T., Atabai, K., Jarreau, P.-H., Ware, L.B., Pugin, J., Matthay, M.A. Pulmonary edema fluid from

patients with acute lung injury augments alveolar epithelial repair by an IL-1β dependent mechanism. Am. J.

Respir. Crit. Care Med. 163:1384-1388, 2001.

7. Ware, L.B., Matthay, M.A. Alveolar fluid clearance is impaired in the majority of patients with acute lung

injury. Am. J. Respir. Crit. Care Med. 163:1376-1383, 2001.

8. Ware, L.B., Conner, E.R., Matthay, M.A. Von Willebrand factor antigen is an independent marker of poor

outcome in patients with early acute lung injury. Crit. Care Med. 29(12):2325-2331, 2001. Olman, M.A.,

White, K.E., Ware, L.B., Cross, M.T., Zhu, S., Matthay, M.A. Microarray analysis indicates that pulmonary

edema fluid from patients with acute lung injury mediates inflammation, mitogen gene expression, and

fibroblast proliferation through bioactive interleukin-1. Chest 121:69S-70S, 2002.

9. Atabai, K., Ishigaki, M, Geiser, T., Ueki, I., Matthay, M.A., Ware, L.B.. Keratinocyte growth factor can

enhance alveolar epithelial repair by nonmitogenic mechanisms. Am. J. Physiol.: Lung Cell. Mol. Physiol.

283:L163-L169, 2002.

10. Atabai, K., Ware, L.B., Snider, M.E., Koch, P., Daniel, B., Nuckton, T., Matthay, M.A.. Aerosolized beta-2

adrenergic agonists achieve therapeutic levels in the pulmonary edema fluid of ventilated patients with acute

respiratory failure. Intensive Care Med. 28(6):705-711, 2002.

11. Ware, L.B., Wang, Y., Fang, X., Warnock, M., Sakuma, T., Hall, T., Matthay, M.A. Assessment of lungs

rejected for transplantation and implications for donor selection. Lancet 360:619-620, 2002.

12. Pham, I., Uchida, T., Planes, C., Ware, L.B., Kaner, R., Matthay, M.A., Clerici, C. Hypoxia upregulates

VEGF expression in alveolar epithelial cells in vitro and in vivo. Am. J. Physiol.: Lung Cell Mol. Physiol.

283(5):L1133-L1142, 2002.

13. Ware, L.B., Fang, X., Wang, X., Sakuma, T., Hall, T.S., Matthay, M.A. Selected contribution: mechanisms

that may stimulate the resolution of alveolar edema in the transplanted human lung. J. Appl. Physiol.

93(5):1869-1874, 2002.

14. Albertine, K., Soulier, M.F., Wang, Z., Ishizaka, A., Hashimoto, S., Zimmerman, G.A., Matthay, M.A., Ware,


26

L.B. Fas and Fas Ligand are upregulated in the pulmonary edema and the lung tissue of patients with acute

lung injury and the acute respiratory distress syndrome. Am. J. Pathol. 161(5):1783-1796, 2002.

15. Cheng, I.W., Ware, L.B., Greene, K.E., Nuckton, T.J., Eisner, M.D., Matthay, M.A. Prognostic value of

surfactant proteins A and D in patients with acute lung injury. Crit. Care Med. 31(1):20-27, 2003.

16. Galiacy, S., Planus, E., Lepetit, H., Fereol, S., Laurent, V., Ware, L., Isabey, D., Matthay, M., Jarreau, P.-H.,

Harf, A., d’Ortho, M.-P. KGF promotes cell motility during alveolar epithelial repair in vitro. Exp. Cell Res.

283(2):215-229, 2003.

17. Flori, H.R., Ware, L.B., Glidden, D., Matthay, M.A. Early elevation of plasma soluble intercellular adhesion

molecule-1 in pediatric acute lung injury identifies patients at increased risk of death and prolonged

mechanical ventilation. Pediat. Crit. Care Med. 4(3):315-321, 2003.

18. Ware, L.B., Fang, X., Matthay, M.A. Protein C and thrombomodulin in human acute lung injury. Am. J.

Physiol.: Lung Cell Mol. Physiol. 285(3):L514-L21, 2003.

19. Prabhakaran, P., Ware, L.B., White, K.E., Cross, M.T., Matthay, M.A., Olman, M.A. Elevated levels of

plasminogen activator inhibitor-1 in pulmonary edema fluid predict the outcome of clinical acute lung injury.

Am. J. Physiol.: Lung Cell Mol. Physiol. 285(1):L20-L28, 2003.

20. Bowler, R.P., Velsor, L.W., Duda, B., Chan, E.D., Abraham, E., Ware, L.B., Matthay, M.A., Day, B.J.

Pulmonary edema fluid anti-oxidants are depressed in acute lung injury. Crit. Care Med. 31(9):2309-2315,

2003.

21. Eisner, M.D., Parsons, P., Matthay, M.A., Ware, L.B., Greene, K., and the ARDS Network. Serum surfactant

protein levels and clinical outcomes in patients with acute lung injury. Thorax 59(11):983-988, 2003.

22. Olman, M.A., White, K.E., Ware, L.B., Simmons, W.L., Benveniste, E.N., Zhu, S., Pugin, J., Matthay, M.A.

Pulmonary edema fluid from patients with early lung injury stimulates fibroblast proliferation by IL-1β

induced IL-6 expression. J. Immunol. 172(4):2668-2677, 2004.

23. Wang L, Zhu du M, Su X, Bai CX, Ware LB, Matthay MA. Acute cardiopulmonary effects of a dual-

endothelin receptor antagonist on oleic acid-induced pulmonary arterial hypertension in dogs. Exp. Lung Res.

30(1):31-42, 2004.

24. Bowler, R.P., Duda, B., Chan, E.D., Enghild, J.J., Ware, L.B., Matthay, M.A., Duncan, M.W. A proteomic

analysis of pulmonary edema fluid and plasma in patients with acute lung injury. Am. J. Physiol.: Lung Cell

Mol. Physiol. 286:L1095-L1104, 2004.

25. ARDS Network [includes Dr. Ware]. Higher versus lower positive end-expiratory pressures in patients with

the acute respiratory distress syndrome. N. Engl. J. Med. 351:327-336, 2004.

26. Sue, R.D., Matthay, M.A., Ware, L.B. Human re-expansion pulmonary edema: evidence for a hydrostatic

mechanism. Intensive Care Med. 30:1921-1926, 2004.

27. Ware, L.B., Eisner, M.D., Thompson, B.T., Parsons, P., Matthay, M.A., and the ARDS Network. Significance

of von Willebrand factor in septic and non-septic patients with acute lung injury. Am. J. Respir. Crit. Care

Med. 170:766-772, 2004.

28. Cheng, I.W., Eisner, M.D., Thompson, B.T., Ware, L.B., Matthay, M.A. and the ARDS Network. Acute

effects of tidal volume strategy on hemodynamics, fluid balance and sedation in acute lung injury. Crit. Care

Med. 33:63-70, 2005.

29. Parsons, P.E., Matthay, M.A., Ware, L.B., Eisner, M.D. and the Acute Respiratory Distress Syndrome

Network. Elevated plasma levels of soluble TNF receptor are associated with morbidity and mortality in

patients with acute lung injury. Am. J. Physiol.: Lung Cell. Mol. Physiol. 288:L426-L431, 2005.

30. Ware, L.B., Kaner, R., Crystal, R., Schane, R., Trivedi, N., McAuley, D., Matthay, M.A. VEGF levels do not

distinguish between ARDS and hydrostatic pulmonary edema. Eur. Respir. J. 26:101-105, 2005.

31. Ware, L.B., Fang, X., Wang, Y., Babcock, W., Jones, K., Matthay, M.A. High prevalence of pulmonary

arterial thrombosis in donor lungs that are rejected for transplantation. J. Heart Lung Transplant. 24:1650-1656,

2005.


27

32. Sakuma, T., Gu, X., Wang, Z., Maeda, S., Sugita, M., Sagawa, M., Osanai, K., Toga, H., Ware, L.B.,

Folkesson, H.G., Matthay, M.A. Stimulation of alveolar epithelial fluid clearance in human lungs by

exogenous epinephrine. Crit. Care Med. 34:676-681, 2006.

33. Uchida, T., Shirasawa, M., Ware, L.B., Kojima, K., Hata, Y., Makita, K., Mednick, G., Matthay, Z.A.,

Matthay, M.A. Receptor for Advanced Glycation End-products is a Marker of Type I cell injury in acute lung

injury. Am. J. Respir. Crit. Care Med. 173(9):1008-1015, 2006.

34. Ganter, M.T,, Ware, L.B., Howard, M., Roux, J., Gartland, B., Matthay, M.A., Fleshner, M., Pittet, J.F.

Extracellular heatshock protein 72 is a marker of the stress protein response in acute lung injury. Am. J.

Physiol. Lung. Cell. Mol. Physiol. 291:L354-61, 2006.

35. Bhandari, V., Choo-Wing, R., Lee, C.G., Zhu, Z., Nedrelow, J.H., Chupp, G.L., Matthay, M.A., Ware, L.B.,

Homer, R.J., Elias, J.A. Hyperoxia causes angiopoietin-2 mediated acute lung injury and necrotic cell death.

Nat. Med. 12:1286-93, 2006.

36. Christie, J.D., Robinson, N., Ware, L.B., Plotnick, M., DeAndrade, J., Lama, V., Milstone, A., Orens, J.,

Weinacker, A., Demissie, E., Bellamy, S., Kawut, S., for the Lung Transplant Outcomes Group. Association

of protein C and type-1 plasminogen activator inhibitor with primary graft dysfunction. Am. J. Respir. Crit.

Care Med. 175:69-74, 2007.

37. McClintock, D.E., Ware, L.B., Eisner, M.D., Wickersham, N., Thompson, B.T., Matthay, M.A. and the

NHLBI ARDS Network. Higher urine nitric oxide is associated with improved outcomes in patients with acute

lung injury. Am. J. Respir. Crit. Care Med. 175:256-262, 2007.

38. Flori, H.R., Ware, L.B., Glidden, D., Matthay, M.A. Early elevation of plasma von Willebrand factor antigen

in pediatric acute lung injury is associated with an increased risk of death and prolonged mechanical

ventilation. Pediatr. Crit. Care Med. 8:96-101, 2007.

39. Wang, L., Bastarache, J., Wickersham, N., Fang, X., Matthay, M.A., Ware, L.B. Novel role of the human

alveolar epithelium in regulating intra-alveolar coagulation. Am. J. Respir. Cell. Mol. Biol. 36:497-503, 2007.

40. Fremont, R.D., Kallet, R., Matthay, M.A. Ware, L.B. Post-obstructive pulmonary edema: a case for

hydrostatic mechanisms. Chest 131:1742-1746, 2007.

41. Bastarache, J.A., Wang, L., Geiser, T., Wang, Z.M., Albertine, K.H., Matthay, M.A.,Ware, L.B. The alveolar

epithelium can initiate the extrinsic coagulation cascade through expression of tissue factor. Thorax 62:608-

616, 2007.

42. Ware, L.B., Matthay, M.A., Parsons, P.E., Thompson, B.T., Eisner, M.D. and the NHLBI Acute Respiratory

Distress Syndrome Clinical Trials Network. Pathogenetic and prognostic significance of altered coagulation

and fibrinolysis in patients with acute lung injury. Crit. Care Med. 35:1821-28, 2007.

43. Rice, T.W., Wheeler, A. P., Bernard, G.R., Ware, L.B., and the NIH NHLBI ARDS Network. Comparison of

the SpO2/FiO2 ratio and the PaO2/FiO2 ratio in patients with acute lung injury or acute respiratory distress

syndrome. Chest 132:410-417, 2007.

44. Lee, J.W., Fang X., Dolganov, G., Fremont, R.D., Bastarache, J.A., Ware, L.B., Matthay, M.A. Acute lung

injury edema fluid decreases net fluid transport across human alveolar epithelial type II cells. J. Biol. Chem.

282:24109-19, 2007.

45. Calfee, C.S., Eisner, M.D., Ware, L.B., Thompson, B.T., Parsons, P.E., Wheeler, A.P., Korpak, A., Matthay,

M.A. and the NHLBI ARDS Network. Trauma-associated lung injury differs clinically and biologically from

acute lung injury owing to other clinical disorders. Crit. Care Med. 35:2243-2250, 2007.

46. Covarrubias, M., Ware, L.B., Kawut, S., DeAndrade, J., Milstone, A., Weinacker, A., Orens, J., Lama, V.,

Demissie, E., Christie, J.D., for the Lung Transplant Outcomes Group. Plasma intercellular adhesion

molecule-1 and Von Willebrand factor in primary graft dysfunction following lung transplantation. Am. J.

Transpl. 7:2573-8, 2007.

47. Liu, K.D., Glidden, D.V., Eisner, M.D., Parsons, P.E., Ware, L.B., Wheeler, A., Thompson, B.T., Dhertow,

G.M., Matthay, M.A., and the NHLBI ARDS Network Clinical Trials Group. The predictive value of plasma

biomarkers for acute kidney injury in patients with acute lung injury. Crit. Care Med. 35:2755-61, 2007.


28

48. White, K.E., Ding, Q., Moore, B.B., Peters-Golden, M., Ware, L.B., Matthay, M.A., Olman M.Prostaglandin

E2 mediated IL-1β-related fibroblast mitogenic effects in acute lung injury through differential utilization of

prostanoid receptors. J. Immunol. 180(1):637-646, 2008.

49. McClintock, D., Zhuo, H., Wickersham, N., Matthay M.A., Ware L.B.. Derangements in biomarkers of

inflammation, coagulation and fibrinolysis predict mortality in acute lung injury. Crit. Care. 12:R41, 2008

50. Bastarache, J.A., Wang, L., Wang, Z., Albertine, K.H., Matthay, M.A., Ware L.B. Intra-alveolar tissue factor

pathway inhibitor is not sufficient to block tissue factor procoagulant activity. Am. J. Physiol. Lung Cell Mol.

Physiol. 294(5):L874-L881, 2008.

51. Lawson, W.E., Crossno, P.F., Plolsukhin, V.V., Roldan, J., Cheng, D-S., Lane, K.B., Blackwell, T.R., Xu, C.,

Markin, C., Ware, L.B., Miller, G.G., Loyd, J.E., Blackwell, T.S. Endoplasmic reticulum stress in alveolar

epithelial cells is prominent in IPF: Association with altered surfactant protein processing and herpesvirus

infection. Am. J. Physiol. Lung Cell. Mol. Physiol. 294:L1119-26, 2008.

52. Calfee, C.S., Ware, L.B., Eisner, M.D., Parsons, P.E., Thompson, B.T., Wickersham, N., Matthay, M.A..

Plasma receptor for advanced glycation end-products and clinical outcomes in acute lung injury. Thorax

63:1083-9, 2008.

53. Hoffman, S.A., Wang L., Shah C.V., Ahya V.N., Pochettino A., Olthoff K., Shaked A., Wille K., Lama V.,

Milstone A,. Ware L.B., Orens J., Weinacker A., Demissie E., Bellamy S., Kawut S.M., Hancock W.W., and

Christie J.D. Multiplex analysis of plasma cytokines and chemokines in clinical primary graft dysfunction

post-lung transplantation. Am. J. Transpl. 9(2):389-396, 2009.

54. Calfee, C.S., Eisner, M.D., Parsons, P.E., Thompson, B.T., Matthay, M.A., Ware, L.B., and the NHLBI

ARDS Clinical Trials Network. Soluble intercellular adhesion molecule-1 (sICAM-1) and clinical outcomes

in patients with acute lung injury. Intensive Care Med. 35:248-257, 2009.

55. Pandharipande, P., Shintani, A., Hagerman, H., Sanders, N., St. Jacques, P., Rice, T., Ware, L.B., Bernard, G.,

Ely, E.W. Imputing SaO2/FiO2 ratio for PaO2/FiO2 ratio for the respiratory component of Sequential Organ

Failure Assessment (SOFA) Score. Crit. Care Med. 37:1317-1321, 2009.

56. Iles, K.E., Wright, M.M., Cole, M.P., Saini, D., Welty, N.E., Chumley, P.H., Powell, P.C., Baker, P.R.S.,

Schopfer, F., Matthay, M.A., Ware, L.B., Agarwal, A., Freeman, B.A. Fatty acid transduction of nitric oxide

signaling: nitrolinoleic acid mediates protective effects through regulation of the ERK pathway. Free Radic.

Biol. Med. 9:389-96, 2009.

57. Kropski, J.A., Fremont, R.D., Calfee, C.S., Ware, L.B. Clara Cell Protein (CC16), a marker of lung epithelial

injury, is decreased in plasma and pulmonary edema fluid from patients with acute lung injury. Chest

135:1440-7, 2009.

58. Kawut, S.M., Okun, J., Shimbo, D., Lederer, D.J., De Andrade, J., Lama, V., Milstone, A., Ware, L.B.,

Weinacker, A., Demissie, E., Tracy, R.P., Christie, J.D. Soluble P-selectin and the risk of primary graft

dysfunction after lung transplantation. Chest 136:237-44, 2009.

59. Siew, E., Ware, L.B., Gebretsadik, T., Shintani, A., Wickersham, N., Bossert, F., Ikizler, T.I.. Urine

Neutrophil Gelatinase-Associated Lipocalin moderately predicts acute kidney injury in critically ill adults. J.

Am. Soc. Nephrology. 20(8):1823-32, 2009.

60. Christie, J.D., Shah, C.V., Kawut, S., Mangalmurti, N., Lederer, D., Sonett, J.R., Ahya, V.N., Palmer, S.M.,

DeAndrade, J., Wille, K., Lama, V., Orens, J., Shah, A., Weinacker, A., Demissie, E., Bellamy, S., Ware, L.B.

Plasma levels of receptor for advanced glycation endproducts (RAGE), blood transfusion, and primary graft

dysfunction. Am. J. Respir. Crit. Care. Med. 180:1010-15, 2009.

61. Bastarache, J.A., Fremont, R.D., Kropski, J.A., Bossert, F.L., Ware, L.B. Procoagulant alveolar

microparticles in the lungs of patients with acute respiratory distress syndrome. Am. J. Physiol. Lung Cell.

Mol. Physiol. 297:L1035-41, 2009.

62. Ware, L.B., Fremont, R.D., Bastarache, J.A., Calfee, C.S., Matthay, M.A.. Determining the aetiology of

pulmonary oedema using the oedema fluid-to-plasma protein ratio. Eur. Respir. J. 35:331-7, 2010.

63. Ware, L.B., Koyama, T., Billheimer, D.D., Wu, W., Bernard, G.R., Thompson, B.T., Brower, R.G.,


29

Standiford, T.J., Martin, T.R., Matthay, M.A., and the NHLBI ARDS Clinical Trials Network. Prognostic and

pathogenetic value of combining clinical and biochemical indices in patients with acute lung injury. Chest

137:288-96, 2010.

64. Katayama, M., Ishizaka, A., Sakamoto, M., Fujishima, S., Sekiguchi, K., Asano, K., Betsuyaku, T., Kotani, T.,

Ware, L.B., Matthay, M.A., Hashimoto, S. Laminin γ2 fragments are increased in the circulation of patients

with early-phase acute lung injury. Intensive Care Med. 36:479-86, 2010.

65. Fremont, R.D., Koyama, T., Calfee, C.S., Wu, W., Dossett, L.A., Bossert, F.R., Mitchell, D., Wickersham, N.,

Bernard, G.R., Matthay, M.A., May, A.K., Ware, L.B. Diagnosis of acute lung injury in patients with

traumatic injuries using a panel of biomarkers. J. Trauma 68:1121-7, 2010.

66. Calfee, C.S., Thompson, B.T., Parsons, P.E., Ware, L.B., Matthay, M.A., Wong, H.R. Plasma IL-8 is not an

effective risk stratification tool for adults with vasopressor-dependent septic shock. Crit. Care Med. 38:1436-

41, 2010.

67. Siew, E., Ikizler, T.A., Gebretsadik, T., Shintani, A., Wickersham, N., Bossert, F., Peterson, J.F., Parikh, C.R.,

May, A.K., Ware. L.B. Elevated urinary IL-18 levels at the time of ICU admission predict adverse clinical

outcomes. Clin. J. Am. Soc. Nephr. 5:1497-505, 2010.

68. Ong, T., McClintock, D.E., Kallet, R.H., Ware, L.B., Matthay, M.A., Liu, K.D. Ratio of angiopoietin-2 to

angiopoietin-1 as a predictor of mortality in acute lung injury patients. Crit. Care Med. 38:1845-51, 2010.

69. Stapleton, R.D., Dixon, A.E., Parsons, P.E., Ware, L.B., Suratt, B.T., and the NHLBI Acute Respiratory

Distress Syndrome Network. The association between body mass index and plasma cytokine levels in patients

with acute lung injury. Chest 138:568-77, 2010.

70. Christie, J.D., Bellamy, S., Ware, L.B., Lederer, D., Hadjiliadis, D., Lee, J., Robinson, N., Locallo, AR.,

Wille, K., Lama, V., Palmer, S., Orens, J., Weinacker, A., Demissie, E., Kimmel, S.E., Kawut, S.M.

Construct validity of the definition of primary graft dysfunction after lung transplantation. J. Heart Lung

Transplant. 29:1231-8, 2010.

71. Lee, H.J., Joo, M., Abdorasulnia, R., Young, D.G., Choi, I., Ware, L.B., Blackwell, T.S., Christman, B.W.

Peptidylarginine deiminase2 suppresses inhibitory Kappa B Kinase activity in lipopolysaccharide-stimulated

RAW 264-7 macrophages. J. Biol. Chem. 285:39655-62, 2010.

72. Hsieh, S.J., Ware, L.B., Eisner, M.D., Yu, L., Jacob, P., Havel, C., Goniewicz, M.L., Duan, M., Yturralde, O.,

Matthay, M.A., Benowitz, N.L., Calfee, C.S. Biomarkers increase detection of active smoking and secondhand

smoke exposure in critically ill patients. Crit. Care Med. 39:40-45, 2011.

73. Munshi, R., Johnson, A., Siew, E., Ware, L.B., Ikizler, T.A., Himmelfarb, J., Zager, R.A. Monocyte

chemoattractant protein-1 gene expression and gene activating histone marks: Tools for studying experimental

and clinical acute kidney injury. J. Am. Soc. Nephr. 22:165-75, 2011.

74. Diamond, J.M., Kawut, S.M., Ledere, D.J., Ahya, V.N., Kohl, B., Sonett, J., Palmer, S.M., Crespo, M., Wille,

K., Lama, V., Shah, P.D., Orens, J., Bhorade, S., Weinacker, A., Demissie, E., Bellamy, S., Christie, J.D.,

Ware, L.B. Elevated plasma Clara cell secretory protein concentration is associated with high-grade primary

graft dysfunction. Am. J. Transplant. 11:561-567, 2011.

75. Ware, L.B., Johnson, A.C.M., Zager, R.A. Renal cortical albumin gene induction and urinary albumin

excretion in responses to acute kidney injury. Am. J. Physiol.: Renal Physiol. 300:F628-38, 2011.

76. Fang, A., Studer, S., Kawut, S,M., Ahya, V.N., Lee, J., Wille, K., Lama, U., Ware, L., Orens, J., Weinacker,

A., Palmer, S.M., Crespo, M., Lederer, D.J., Deutschman, C.S., Kohl, B.A., Bellamy, S., Demissie, E.,

Christie, J.D., for the Lung Transplant Outcomes Group. Elevated Pulmonary Artery Pressure is a risk factor

for primary graft dysfunction following lung transplantation for idiopathic pulmonary fibrosis. Chest 139:782-

787, 2011.

77. Haase, M., Devarajan, P., Haase-Fielitz, A., Bellomo, R., Cruz, D.N., Wagener, G., Krawczeski, C.D., Koyner,

J.L., Murray, T., Zappitelli, M., Goldstein, S.L., Makris, K., Ronco, C., Martensson, J., Martling, C.R., Venge,

P., Siew, E., Ware, L.B., Ikizler, A., Mertens, P.R. The outcome of neutrophil gelatinase-associated lipocalin

(NGAL)-positive subclinical acute kidney injury: A multicenter pooled analysis of prospective studies. J. Am.


30

Coll. Cardiol. 57:1752-61, 2011.

78. Bastarache, J.A., Wickersham, N.L., Mitchell, D.B., Mernaugh, R.L., Ware, L.B. Accuracy and

reproducibility of the Searchlight® Multiplex Immunoassay platform: A validation study.

J.Immunol.Methods 31:33-9, 2011.

79. Finigan, J.H., Faress, J.A., Mishra, R., Nethery, D.E., Wyler, D., Shatat, M., Ware, L.B., Matthay, M.A.,

Mason, R., Silver, R.F., Kern, J.A. Neuregulin-1-HER2 signaling is a central regulator of pulmonary

epithelial permeability and acute lung injury. J. Biol.Chem. 286:10660-70, 2011.

80. Rice, T.W., Ware, L.B., Haponik E., Chiles, C., Wheeler, A.P., Bernard, G.R., Steingrub, J., Hite, R.D.,

Matthay, M.A., Wright, P., Ely, E.W., and the NIH NHLBI ARDS Network. Vascular Pedicle Width in acute

lung injury: correlation with intravascular pressures and ability to discriminate fluid status. Crit. Care. 15:R86,

2011.

81. Calfee, C.S., Ware, L.B., Glidden, D.V., Wisner, M.D., Parsons, P.E., Thompson, B. T., Matthay, M.A. Use

of risk reclassification with multiple biomarkers improves mortality prediction in acute lung injury. Crit. Care

Med. 39: 711-717, 2011.

82. O’Neal, H.T., Koyama, T., Koehler, E.A.S, Siew, E., Curtis, B.R., Fremont, R.D., May,A.K., Bernard,G.R.,

Ware, L.B. Prehospital statin and aspirin use and the prevalence of severe sepsis and ALI/ARDS. Crit. Care

Med. 39:1343-50, 2011.

83. Meyer, N.J., Li, M., Feng, R., Bradfield, J., Gallop,R., Localio, A.R., Bellamy, D., Fuchs, B.F., Lanken, P.N.,

Albelda, S.M., Ware, L.B., Wurfel, M.M., Hakonarson, H., Christie, J.D. Identification and replication of an

ANGPT2 variant associated with trauma-associated acute lung injury. Am. J. Respir. Crit. Care Med. 183:

1344-53, 2011.

84. Bastarache, J.A., Ong, T., Matthay, M.A., Ware, L.B. Alveolar fluid clearance is faster in women with acute

lung injury compared to men. J.Crit.Care 26: 249-56, 2011.

85. Ware, L.B., Fessel, J.P., May, A.K., Roberts, L.J. II. Plasma biomarkers of oxidant stress and development of

organ failure in severe sepsis. Shock 36: 12 – 17, 2011.

86. Ware, L.B., Koyama, T., Billheimer, D., Landeck, M., Johnson, E., Brady, S., Bernard, G.R., Matthay, M.A.,

and the California Transplant Donor Network. Advancing donor management research: design and

implementation of a large randomized placebo controlled trial. Ann. Intens. Care 1:20, 2011

87. Polosukhin, V., Cates, J., Lawson, W., Zaynagetdinov, R., Milstone, A., Massion, P., Ocak, S., Ware, L.B.,

Lee, J., Bowler, R., Kononov, A., Randell, S., Blackwell, T.. Bronchial secretory IgA deficiency correlates

with airway inflammation and progression of COPD. Am. J. Respir. Crit. Care Med. 184:317-27, 2011.

88. Sims, M.W., Beers, M.F., Ahya, V.N., Kawut, S.M., Sims, K.D., Lederer, D.J., Palmer, S.M., Willie, K.,

Lama, V., Shah, P.D., Orens, J.B., Bhorade, S., Crespo, M., Weinacker, A., Demissie, E., Bellamy, S., Christie,

J.D., Ware, L.B., for the Lung Transplant Outcomes Group. Effect of single versus bilateral lung

transplantation on plasma surfactant protein-D levels in idiopathic pulmonary fibrosis. Chest 140:489-96,

2011.

89. Johnson, A.C.M., Ware, L.B., Himmelfarb, J., Zager, R.A. HMG-CoA reductase activation and urinary pellet

cholesterol elevations in acute kidney injury. Clin. J. Am. Soc. Nephrol. 6:2108-13, 2011.

90. Bastarache, J.A., Sebag, S., Grove, B.S., Ware, L.B. IFN-α and TNFα act synergistically to upregulate tissue

factor in alveolar epithelial cells. Exp. Lung Res. 37:507-17, 2011.

91. Diamond, J.M., Lederer, D., Kawut, S.M., Lee, J., Cantu, E., Ahya, V., Bellamy, S., Palmer, S., Lama, V.,

Bhorade, S., Crespo, M., Demissie, E.J., Sonett, J., Wille, K., Orens, J.B., Shah, P.D., Weinacker, A., Weill,

D., Kohl, B., Deutschman, C., Arcasoy, S., Shah, A., Belperio, J., Wilkes, D., Reynolds, J.M., Ware, L. and

Christie, J.D. for the Lung Transplant Outcomes Group. Elevated plasma long pentraxin-3 levels and primary

graft dysfunction after lung transplantation for idiopathic pulmonary fibrosis. Am. J. Transplant. 11:561-7,

2011.

92. Heffernan, D.S., Dossett, L.A., Lightfoot, M.A., Fremont, R.D., Ware, L.B., Sawyer, R.G., May, A.K. Gender

and ARDS in critically injured adults: A prospective study. J Trauma. 71:878-85, 2011.


31

93. Lederer, D.J., Kawut, S.M., Wickersham, N., Winterbottom, C., Bhorade, S., Palmer, S.M., Lee, J., Diamond,

J., Wille, K.M., Weinacker, A., Lama, V.N., Crespo, M., Orens, J.B., Sonett, J.R., Arcasoy, S.M., Ware, L.B.,

Christie, J.D., for the Lung Transplant Outcomes Group. Obesity and primary graft dysfunction after lung

transplantation: the LTOG obesity study. Am. J. Respir. Crit. Care Med. 9:1048-54, 2011.

94. Christie, J.D., Wurfel, M.M., Feng, R., O’Keefe, G.E., Bradfield, J., Ware, L.B., Christiani, D.C., Calfee,

C.S., Meyer, N.J., Kim, C., Li, M., Akey, J., Barnes, K.C., Sevransky, J., Lanken, P.N., Aplenc, R.A.,

Maloney, J.P, Hakonarson, H. Genome wide association identifies PPFIA1 as a candidate gene for acute lung

injury risk following major trauma. PLOS One 7(1): e28268, 2012.

95. Polosukhin, V.V., Degryse, A.L., Newcomb, D.C., Jones, B.R., Ware, L.B., Lee, J.W., Loyd, J.E., Blackwell,

T.S., Lawson, W.E. Intratracheal bleomycin causes airway remodeling and airflow obstruction in mice. Exp

Lung Res. 38; 135-46, 2012.

96. Annane, D., Mira, J.P., Ware, L.B., Gordon, A., Sevranski, J., Stüber, F., Heagerty, P.J., Wellman, H.F.,

Neira, M., Mancini, A.D.J., Russell, J.A.. Design, conduct and analysis of a multicenter pharmacogenomic

biomarker study in matched patients with severe sepsis treated with or without drotecogin Alfa (activated).

Ann. Intensive Care 2:15, 2012

97. Dolinay, T., Young, S.K., Howrylak, J., An, C.H., Fredenburgh, L., Massaro, A.F., Rogers, A., Hunninghake,

G.M., Gaxourian, L., Landazury, R., Epannapaly, S., Christie, J., Ware, L.B., Christiani, D., Ryter, S.W.,

Baron R.M., Choi, A.M.K. Inflammasome-regulated cytokines are critical mediators of acute lung injury. Am.

J. Respir. Crit. Care Med. 185:1225-34, 2012

98. Bastarache, J.A., Diamond, J.M., Kawut, S.M., Lederer, D.J., Ware, L.B, Christie, J.D. Post-operative

estradiol levels associate with the development of primary graft dysfunction in lung transplant recipients.

Gender Med. 9:154-165, 2012

99. Shah, R.J., Bellamy, S.L., Localio, A.R., Wickersham, N., Diamond, J.M., Weinacker, A. Lama, V.N.,

Bhorade, S., Belperio, J.A., Crespo, M., Demissie, E.J., Kawut, S.M., Wille, K.M., Ledered, D.J., Lee, J.C.,

Palmer, S.M., Orens, J., Reynolds, J., Shah, A., Wilkes, D.S., Ware, L.B.*, Christie, J.D.* A panel of lung

injury biomarkers enhances the definition of primary graft dysfunction (PGD) after lung transplantation. J

Heart and Lung Transplant. 31:942-9, 2012

100. Diamond, J.M., Meyer, N.J., Feng, R., Rushefski, M., Lederer, D.J., Kawut, S.M.,Lee, J., Cantu, E., Bellamy,

E., Sonett, J., Wille, K., Orens, J., Weinacker, A., Weill, D., Kohl, B.A., Arcasoy, S., Shah, A.S., Shah, P.D.,

Belperio, J.A., Wilkes, D., Reynolds, J.M., Ware, L.B., Palmer, S.M., Christie, J.D. for the Lung Transplant

Outcomes Group. Variation in PTX3 is Associated With Primary Graft Dysfunction After Lung

Transplantation. Am. J. Respir. Crit. Care Med. 186:546-552, 2012.

101. Wu, H., Chen, Q., Ware, L.B., Koyama, T. A Bayesian approach for generalized linear model with an

explanatory biomarker measurement variables subject to detection limit – an application to acute lung injury.

J. Appl. Statistics. 39:1733-47, 2012.

102. Girard, T.D., Ware, L.B., Bernard, G.R., Pandharipande, P.P., Thompson, J.L., Shintani, A.K., Jackson, J.C.,

Ely, E.W. Associations of biomarkers of inflammation and coagulation with delirium during critical illness.

Intens. Care Med. 38: 1965-73, 2012.

103. Zeyed, Y.G., Bastarache, J.A., Matthay, M.A., Ware, L.B. The severity of shock is associated with impaired

rates of net alveolar fluid clearance in clinical acute lung injury. Am. J. Physiol. Lung Cell. Mol. Physiol.

303:L550-5, 2012.

104. Ware, L.B., Neyrinck, A., O’Neal, H.R., Lee, J.W., Landeck, M., Johnson, E., Calfee, C.S., Matthay, M.A.

and the California Transplant Donor Network. Comparison of chest radiographic scoring to lung weight as a

quantitative index of pulmonary edema in organ donors. Clin. Transpl. 26:665-71, 2012.

105. Bastarache, J.A., Ware, L.B., Girard, T.D., Wheeler, A.P., Rice, T.W. Markers of inflammation and

coagulation may be modulated by enteral feeding strategy. J. Parenter. Enteral Nutr. 36:732-40, 2012.

106. Shah, R.J., Diamond J.M., Lederer, D.J., Arcasoy, S.M., Canta, E., Demissie, E.J., Kawut, S.M., Kohl, B., Lee,

J.C., Sonett, J., Christie, J.D., Ware, L.B. Plasma monocyte chemotactic protein-1 (MCP-1) levels are a

biomarker of primary graft dysfunction following lung transplantation. Transl. Res. 160:435-42, 2012.


32

107. Bastarache, J.A., Sebag, S.C., Clune, J.K., Grove, B.S., Lawson, W.E., Janz, D.R., Roberts, L.J.II, Dworski, R.,

Mackman, N., Ware, L.B. Low levels of tissue factor lead to alveolar hemorrhage, potentiating murine acute

lung injury and oxidative stress. Thorax 67:1032-9, 2012.

108. Diamond, J.M., Porteous, M., Cantu, E., Meyer, N., Lederer, D.J., Kawut, S.M., Lee, J., Bellamy, S., Palmer,

S.M., Lama, V.N., Bhorade, S., Crespo, M., Demissie, E., Wille, K., Orens, J., Shah, P.D., Weinacker, A.,

Weill, D., Arcasoy, S., Wilkes, D., Ware, L.B., Christie, J.D. Elevated Plasma Angiopoeitin-2 Levels and

Primary Graft Dysfunction after Lung Transplantation. PLoS One 7:e51932, 2012.

109. Ware, L.B., Magarik, J.A., Wickersham, N., Cunningham, G., Rice, T.W., Christman, B.W., Wheeler, A.P.,

Bernard, G.R., Summar, M. Low plasma levels of citrulline are associated with development of ARDS in

patients with severe sepsis. Crit.Care 17:R10, 2013.

110. Morandi, A., Barnett, N., Miller, R., Girard, T.D., Pandharipande, P.P., Ely, E.W., Ware, L.B. Vitamin D and

delirium in critically ill patients: A preliminary investigation. J. Crit. Care 28:230-5, 2013.

111. Janz, D.R., Bastarache, J.A., Peterson, J.F., Sills, G., Wickersham, N., May, A.K., Roberts, L.J. II, Ware, L.B.

Association between cell-free hemoglobin, acetaminophen and mortality in patients with sepsis: an

observational study. Crit. Care Med. 41:784-90, 2013.

112. Roux, J., Carles, M., Koh, H., Goolaerts, A., Howard, M., Houseman, B.T., Shokat, K.M., Paquet, A.C., Ware,

L.B., Matthay, M.A., Pittet, J.F. IL-8 inhibits cAMP-stimulated alveolar epithelial fluid transport via a

GRK2/P13K- dependent mechanism. F.A.S.E.B. J. 27:1095-106, 2013.

113. Shah, R.J., Bellamy, S.L., Lee, J.C., Cantu, E., Diamond, J.M., Mangalmurti, N., Kawut, S.M., Ware, L.B.,

Christie, J.D. Early plasma soluble receptor for advanced glycation end-product (sRAGE) levels are

associated with bronchiolitis obliterans syndrome. Am. J. Transpl. 13:754-9, 2013.

114. Sebag, C.C., Bastarache, J.A., Ware, L.B. Mechanical stretch inhibits lipolysaccharide (LPS)-induced KC

and tissue factor expression while increasing procoagulant activity in murine lung epithelial cells J.Biol.Chem.

288:7875-84, 2013.

115. Diamond, J.M., Lee, J.C., Kawut, S.M., Shah, R.J., Localio, A.R., Bellamy, S., Lederer, D.J., Cantu, E., Kohl,

B.A., Lama, V.N., Bhorade, S., Crespo, M., Demissie, E., Sonnett, J., Wille, K., Orens, J., Shah, A.S.,

Weinacker, A., Acasoy, S., Shah, P.D., Wilkes, D.S., Ware, L.B., Palmer, S.M., Christie, J.D. Clinical Risk

Factors for Primary Graft Dysfunction after Lung Transplantation. Am. J. Respir. Crit. Care Med. 187:527-

34, 2013.

116. Shah, R.J., Diamond, J.M., Cantu, E., Lee, J.C., Lederer, D.J., Lama, V.N., Orens, J., Weinacker, A., Wilkes,

D.S., Bhorade, S., Wille, K.M., Ware. L.B., Palmer, S.M., Crespo, M., Localio, A.R., Demissie, E.J., Kawut,

S.M., Bellamy, S.L., Christie, J.D. Latent class analysis identifies distinct phenotypes of primary graft

dysfunction after lung transplantation. Chest 144:616-22, 2013.

117. Janz, D.R., Zhao, Z., Koyama, T., Cripps, B., May, A.K., Bernard, G.R., Bastarache, J.A., Young, P.P., Ware,

L.B. Longer storage duration of red blood cells is associated with an increased risk of acute lung injury in

patients with sepsis. Ann Intensive Care 3:33, 2013.

118. Ware, L.B., Koyama, T., Zhao, Z., Janz, D.R., Wickersham, N., Bernard, G.R., May, A.K., Calfee, C.S.,

Matthay, M.A.. Biomarkers of lung epithelial injury and inflammation distinguish severe sepsis patients with

acute respiratory distress syndrome. Crit Care 17:R253, 2013.

119. Siew, E.D., Ware, L.B., Bian, A., Shintani, A., Eden, S., Wickersham, N., Cripps, B., Ikizler, T.A.. Distinct

injury markers for the early detection and prognosis of incident AKI in critically ill adults with preserved

kidney function. Kidney Int., 84:786-94, 2013.

120. Janz, D.R., Bastarache, J.A., Sills, G., Wickersham, N., May, A.K., Bernard, G.R., Ware, L.B.. Association

between haptoglobin, hemopexin and mortality in adults with sepsis. Crit Care 17:R272, 2013.

121. Shah, R.J., Wickersham, N., Lederer, D.J., Palmer, S.M., Cantu, E., Diamond, J.M., Kawut, S.M., Lama, V.N.,

Bhorade, S., Crespo, M., Demissie, E., Sonett, J., Wille, K., Orens, J., Weinacker, A., Shah, P., Arcasoy, S.,

Wilkes, D., Christie, J.D., Ware, L.B.. Pre-operative plasma club (clara) cell secretory protein levels are

associated with primary graft dysfunction after lung transplantation. Am J Transplant 14:446-52, 2014.


33

122. Kangelaris, K.N., Calfee, C.S., May, A.K., Zhuo, H., Matthay, M.A., Ware, L.B. Is there still a role for the

Lung Injury Score in the era of the Berlin definition ARDS? Ann Intensive Care 4:4, 2014.

123. Wang, C.Y., Calfee, C.S., Paul, D., Janz, D.R., May, A.K., Zhuo, H., Bernard, G.R., Matthay, M.A., Ware,

L.B., Kangelaris, K.N. One-year mortality and predictors of death among hospital survivors of acute

respiratory distress syndrome. Intensive Care Med 40:388-96, 2014.

124. Barnett, N., Zhao., Z., Koyama, T., Janz, D.R., Wang, C.Y., May, A.K., Bernard, G.R., Ware, L.B. Vitamin

D deficiency and risk of acute lung injury in severe sepsis and severe trauma: a case control study. Ann

Intensive Care 4:5, 2014.

125. Diamond, J.M., Akimouci, T., Feng, R., Kawut, S.M., Meyer, N.J., Shah, R.J., Canter, E., Lee, J.C., Hancock,

W.W., Aplenc, R., Ware, L.B., Palmer, S.M., Bhorade, S., Lama, V.N., Weinacker, A., Orens, J., Wille, K.,

Crespo, M., Lederer, D.J., Arcasoy, S., Demissie, E., Christie, J.D., for the Lung Transplant Outcomes Group.

Genetic variation in prostaglandin E2 pathway is associated with primary graft dysfunction. Am J Respir Crit

Care Med 89:567-75, 2014.

126. Ware, L.B., Landeck, M., Koyama, T., Zhao, Z., Singer, J., Kern, R., Johnson, E., Janz, D.R., Bernard, G.R.,

Lee, J.W., Matthay, M.A., and the California Transplant Donor Network. A randomized trial of the effects of

nebulized albuterol on pulmonary edema in brain-dead organ donors. Am. J. Transplant 14: 621-8, 2014.

127. Chen, Q. Wu, H., Ware, L.B., Koyama, T.. A Bayesian approach for the Cox proportional hazards model

with covariates subject to detection limit. Int. J. Stats. Med. Res. 3:32-43 2014.

128. Shah, R.J., Emtiazjoo, A.M., Diamond, J.M., Smith, P.A., Roe, D.W., Wille, K.M., Orens, J.B., Ware, L.B.,

Weinacker, A., Lama, V.N., Bhorade, S.M., Palmer, S.M., Crespo, M., Lederer, D.J., Cantu, E., Eckert, G.J.,

Christie, J.D., Wilkes, D.S.. Plasma complement levels are associated with primary graft dysfunction and

mortality after lung transplantation. Am. J. Respir. Crit. Care Med. 189: 1564-7, 2014.

129. Bastarache, J.A., Koyama, T., Wickersham, N.E., Ware, L.B.. Validation of a multiplex

electrochemiluminescent immunoassay platform in human and mouse samples. J. Immunol. Methods 408: 13-

23, 2014.

130. Reilly, J.P., Bellamy, S., Shashaty, M.G.S., Gallop, R., Meyer, N.J., Lanken, P.N., Kaplan, S., Holena, D.N.,

May, A.K., Ware, L.B., Christie, J.D.. Heterogeneous Phenotypes of the Acute Respiratory Distress

Syndrome after Major Trauma. Ann. Am. Thorac. Soc. 11:728-36, 2014.

131. Calfee, C.S., Delucchi, K., Parsons, P.E., Thompson, B.T., Ware, L.B., Matthay, M.A., and the NHLBI

ARDS Network. Subphenotypes in acute respiratory distress syndrome: latent class analysis of data from two

randomised controlled trials. Lancet Respir Med 2: 611-20, 2014.

132. Ware, L.B., Lee, J.W., Wickersham, N., Nguyen, J., Matthay, M.A., Calfee, C.S.. Donor smoking is

associated with pulmonary edema, inflammation and epithelial dysfunction in ex vivo human donor lungs.

Am. J. Transpl. 14:2295-302, 2014.

133. Brittain, E.L., Janz, D.R., Austin, E.D., Bastarache, J.A., Wheeler, L.A., Ware, L.B., Hemnes, A.R..

Elevation of plasma cell free hemoglobin in pulmonary arterial hypertension. Chest, 146:1478-85, 2014.

134. Sowards, K.J., Mukherjee, K., Norris, P.R., Shintani, A., Ware, L.B., Roberts, L.J., May, A.K.. Elevated

serum creatine phosphokinase is associated with mortality and inotropic requirement in critically injured

adults. Injury 45: 2096-2100, 2014.

135. Singer, J., Peterson, E.R., Synder, M.E., Golden, J.A., D’Ovidio, F., Bacchetta, M., Sonett, J.R., Kukreja, J.,

Shah, L., Robbins, H., Van Horn, K., Shah, R.J., Wickersham, N., Sun, L., Hays, S., Arcasoy, S.M., Palmer,

S.M., Ware, L.B., Christie, J.D., Lederer, D.J. Body composition and mortality after adult lung

transplantation in the United States. Am J Respir Crit Care Med. 190: 1012-21, 2014.

136. West, J.D., Austin, E.D, Gaskill, C., Marriott, S., Baskir, R., Bilousova, G., Jean, J.C., Hemnes, A.R., Menon,

S., Bloodworth, N.C., Fessel, J.P., Kropski, J.A. Irwin, D.C., Ware, L.B., Wheeler, L.A., Hong, C.C.,

Meyrick B.O., Loyd, J.E., Bowman, A.B., Ess, K.C., Klemm, D.J., Young, P.P., Merryman, W.D., Kotton, D.,

Majka, S.M.. Identification of a common Wnt associated genetic signature across multiple cell types in

pulmonary arterial hypertension. Am J Physiol Cell Physiol. 307:C415-30, 2014.


34

137. Chen, W., Janz, D.R., Bastarache, J.A., May, A.K., O'Neal, H.R. Jr, Bernard, G.R., Ware, L.B.. Prehospital

aspirin use is associated with reduced risk of acute respiratory distress syndrome in critically ill patients: a

propensity-adjusted analysis. Crit. Care Med. 43:801-7, 2015.

138. Sayah, D.M., Mallavia, B., Liu, F., Ortiz-Muñoz, G., Caudrillier, A., DerHovanessian, A., Ross, D.J., Lynch,

III J.P., Saggar, R., Ardehali, A., Ware, L.B., Christie, J.D., Belperio, J.A., Looney, M.R. and the LTOG

Investigators. Neutrophil extracellular traps are pathogenic in primary graft dysfunction after lung

transplantation. Am. J. Respir. Crit. Care Med. 191:455-63, 2015.

139. Janz, D.R., Bastarache, J.A., Rice, T. W., Bernard, G.R., Warren, M.A., Wickersham, N., Sills, G., Oates, J.A.,

Roberts, L.J. II, Ware, L.B.. Randomized, Placebo-controlled Trial of Acetaminophen for the Reduction of

Oxidative Injury in Severe Sepsis: The ACROSS Trial. Crit Care Med. 43:534-41, 2014.

140. Sapru, A., Calfee, C.S., Liu, K.D., Kangelaris, K., Hansen, H., Pawlikowska, L., Ware, L.B., Al Khouli, M.,

Abbot, J., Matthay, M.A.. Plasma soluble thrombomodulin levels are associated with mortality in the acute

respiratory distress syndrome. Intens. Care Med. 41:470-8, 2014.

141. Kropski, J.A., Pritchett,

J.M., Zoz,

D.F., Crossno,

P.F., Markin,

C., Garnett,

E.T., Degryse,

A.L., Mitchell,

D.B.,

Polosukhin, V.V., Rickman,

O.B., Choi,

L., Cheng,

D.-S., McConaha,

M.E., Jones,

B.R., Gleaves,

L.A.,

Worrell, J.A., Solus,

J.F., Ware,

L.B., Stein,

C.M., Lee,

J.W., Massion,

P.P., Zaynagetdinov,

R., White,

E.S.,

Johnson, J.E., Groshong,

S.D., Lancaster,

L.H., Young,

L.R., Steele,

M.P., Phillips III,

J.A., Cogan,

J.D., Loyd,

J.E., Lawson, W.E., Blackwell, T.S.. Extensive phenotyping of individuals at-risk for Familial Interstitial

Pneumonia reveals clues to the pathogenesis of interstitial lung disease. Am. J. Respir. Crit. Care Med.

191:417-26, 2015.

142. Parr, S.K., Clark, A.J., Bian, A., Shintani, A., Wickersham, N.E., Ware, L.B., Ikizler, T.A., Siew, E.D..

Urinary L-FABP Predicts Poor Outcomes In Critically Ill Patients with Early AKI. Kidney Int. 87:640-8,

2015.

143. Calfee, C.S. Janz, D.R., Bernard, G.R., May, A.K., Kangelaris, K.N., Matthay, M.A., Ware, L.B.. Distinct

molecular phenotypes of direct versus indirect ARDS in single-center and multi-center studies. Chest

147:1539-48, 2015.

144. Shaver, C.M., Chen, W., Janz, D.R., May, A.K., Darbar, D., Bernard, G.R., Bastarache, J.A., Ware, L.B..

Atrial fibrillation is an independent predictor of mortality in critically ill patients. Crit Care Med 43: 2104-11,

2015.

145. Ma, L., Shaver, C.M., Grove, B.S., Mitchell, D.B., Wickersham, N.E., Carnahan, R.H., Cooper, T.L., Brake,

B.E., Ware, L.B., Bastarache, J.A.. Kinetics of lung tissue factor expression and procoagulant activity in

bleomycin induced acute lung injury. Clin Transl Med, 4: 63, 2015.

146. Calfee, C.S., Matthay, M.A., Benowitz, N., Kangelaris, K.N., Siew, E., Janz, D.R., Bernard, G.R., May, A.K.,

Jacob, P., Havel, C., Ware, L.B.. Cigarette smoke exposure and the acute respiratory distress syndrome. Crit

Care Med 43: 1790-7, 2015.

147. Shah, R.J., Diamond, J.M., Cantu, E., Flesch, J., Lee, J.C., Lederer, D.J., Lama, V.N., Orens, J., Weinacker, A.,

Wilkes, D.S., Roe, D., Bhorade, S., Wille, K.M., Ware, L.B., Palmer S., Crespo, M., Demissie, E.J., Sonnet,

J., Shah, A., Kawut, S.M., Bellamy, S.L., Localio, A.R., Christie, J.D.. Objective estimates improve risk

stratification for primary graft dysfunction after lung transplantation. Am J Transplant 15: 2188-96, 2015.

148. Chen, W., Chen, Y.-Y., Tsai, C.-F., Chen, S.C.-C., Lin, M.-S., Ware, L.B., Chen, C.-M.. Incidence and

outcomes of acute respiratory distress syndrome--a nationwide registry-based study in Taiwan, 1997-2011.

Medicine 94:e1849, 2015.

149. Chen, W., Janz, D.R., Shaver, C.M., Bernard, G.R., Bastarache, J.A., Ware, L.B.. Clinical characteristics and

outcomes are similar in ARDS diagnosed by SpO2/FiO2 ratio compared with PaO2/FiO2 ratio. Chest

148:1477-83, 2015.

150. Shaver, C.M., Grove, B.S., Putz, N., Clune, J.K., Lawson, W.E., Carnahan, R.H., Ware, L.B., Bastarache,

J.A.. Regulation of alveolar procoagulant activity and permeability in direct acute lung injury by lung

epithelial tissue factor. Am J Respir Cell Molec Biol 53: 719-27, 2015.

151. Kangelaris, K.N., Ware, L.B., Wang, CY, Zhuo, H, Matthay, M.A., Calfee, C.S.. Timing of intubation and


35

clinical outcomes in adults with acute respiratory distress syndrome. Crit Care Med 44:120-9, 2016.

152. Du, R.H., Richmond, B.W., Blackwell, T.S. Jr., Cates, J.M., Massion, P.P., Ware, L.B., Lee, J.W., Kononov,

A.V., Lawson, W.E., Blackwell, T.S., Polosukhin, V.V.. Secretory IgA from submucosal glands does not

compensate for its airway surface deficiency in chronic obstructive pulmonary disease. Virchows Arch

467:657-66, 2016.

153. Cantu, E., Suzuki, Y., Diamond, J.M., Ellis, J., Tiwari, J., Beduhn, B., Nellen, J., Shah, R., Meyer, N.J.,

Lederer, D.J., Kawut, S.M., Palmer, S.M., Snyder, L., Hartwig, M.G., Lama, V.N., Bhorade, S., Crespo, M.,

Demissie, E., Wille, K., Orens, J., Shah, P.D., Weinacker, A., Weill, D., Wilkes, D., Roe, D., Ware, L.B.,

Feng, R., Christie, J.D. for the Lung Transplant Outcomes Group. Protein quantitative trait loci analysis

identifies genetic variation in the innate immune regulator TOLLIP in post lung transplant primary graft

dysfunction risk. Am J Transpl 16:833-40, 2016.

154. Shaver, C.M., Grove, B.S., Clune, J.K., Mackman, N., Ware, L.B., Bastarache, J.A.. Myeloid tissue factor

does not modulate lung inflammation or permeability during experimental acute lung injury. Scientific

Reports 6:22249, 2016.

155. Diamond, J.M., Porteous, M., Roberts II, L.J., Wickersham, N., Rushefski, M., Kawut, S.M., Shah, R.J., Cantu,

E., Lederer, D.J., Lama, V.N., Bhorade, S., Crespo, M., Wille, K., Orens,, J., Weinacker, A., Arcasoy, S., Shah,

P.D., Wilkes, D.S., Palmer, S.M., Calfee, C.S., Ware, L.B., Christie, J.D., for the Lung Transplant Outcomes

Group. The relationship between plasma lipid peroxidation products and primary graft dysfunction is

modified by donor smoking and reperfusion hyperoxia. J Heart Lung Transpl 35:500-7, 2016.

156. Ware, L.B., Zhao, Z., Koyama, T., May, A.K., Matthay, M.A., Lurmann, F.W., Balmes, J.R., Calfee, C.S..

Long-term ozone exposure increases the risk of developing the acute respiratory distress syndrome. Am J

Respir Crit Care Med 193: 1143-50, 2016.

157. Sapru, A., Liu, K.D., Wiemels, J., Hansen, H., Pawlikowska, L., Poon, A., Jorgenson, E., Witte, J.S., Calfee,

C.S., Ware, L.B., Matthay, M.A., and the NHLBI ARDS Network. Association of common genetic variation

in the protein C pathway genes with clinical outcomes in acute respiratory distress syndrome. Crit Care.

20:151, 2016.

158. Kor, D.J., Carter, R.E., Park, P.K., Festic, E., Banner-Goodspeed, V.M., Hinds, R., Talmor, D., Gajic, O.,

Ware, L.B., Gong, M.N.. Effect of aspirin on development of ARDS in at-risk patients presenting to the

emergency department: The LIPS-A Randomized Clinical Trial. JAMA 315:2406-2414, 2016.

159. Shaver, C.M., Upchurch, C.P., Janz, D.R., Grove, B.S., Putz, N., Wickersham, N., Richmond, B.W., Ware,

L.B., Bastarache, J.A.. Cell-free hemoglobin: A novel mediator of acute lung injury. Am J Physiol Lung Cell

Mol Physiol 310:L532-41, 2016.

160. Zackular, J.P., Moore, J.L., Jordan, A.T., Juttukonda, L.J., Noto, M.J., Nicholson, M.R., Crews, J.D., Semler,

M.W., Zhang, Y., Ware, L.B., Washington, M.K., Chazin, W.J., Caprioli, R.M., Skaar, E.P.. Dietary zinc

alters the microbiota and decreases resistance to Clostridium difficile. Nat Med 22:1330-4, 2016.

161. Mathias, R.A., Taub, M., O'Connor, T.D., Fu, W., Gignoux, C.R., Vergara, C., Torgerson, D., Pino-Yanes, M.,

Shringarpure, S., Huang, L., Rafaels, N., Johnston, H.R., Ortega, W., Levin, A.M., Padhukasahasram, B., Eng,

C., Mejia-Mejia, D.-A., Ferguson, T., Qin, Z.S., Scott, A.F., Yazdanbakhsh, M., Wilson, J.G., Marrugo, J.,

Lange, L.A., Kumar, R., Avila, P., Williams, L.K., Watson, H., Ware, L.B., Olopade, S., Oliveira, R., Ober,

C., Nicholae, D., Meyers, D., Mayorga, A., Knight-Madden, J., Hartert, T.V., Hansel, N., Foreman, M., Ford,

J., Figueiredo, C., Faruque, M., Dunston, G.M., Cooper, P.J., Caraballo, L., Burchard, E.G., Bleecker, E.,

Barreto, M., Araujo, M., Herrera-Paz, E.F., Gietzen, K., Grus, W.E., Bustamante, C., Kenny, E.E., Bamshad,

M., Hernandez, R., Akey, J., Beaty, T.H., Ruckzinski, I., CAAPA, and Barnes K.C.. A continuum of

admixture in the Western Hemisphere revealed by the African Diaspora genome. Nat Comm 11:1252, 2016.

162. Hughes, C.G., Pandharipande, P.P., Thompson, J.L., Chandrasekhar, R., Ware, L.B., Ely, E.W., Girard, T.D..

Endothelial activation and blood-brain barrier injury as risk factors for delirium in critically ill patients. Crit

Care Med 44:e809-17, 2016.

163. Russell, D.W., Janz, D.R., Emerson, W.L., May, A.K., Bernard, G.R., Zhao, Z., Koyama, T., Ware, L.B..

Early exposure to hyperoxia and mortality in critically ill patients with severe traumatic injuries. BMC Pulm

Med 17:29, 2017.


36

164. Zhao, B., Lu, Q., Cheng, Y., Belcher, J.M., Siew, E.D., Leaf, D.E., Body, S.C., Fox, A.A., Walkar, S.W.,

Collard, C.D., Thiessen-Philbrook, H., Ikizler, T.A., Ware, L.B., Edelstein, C., Garg, A.X., Choi, M., Schaub,

J., Zhao, H., Lifton, R.P., Parikh, C.R., for the TRIBE-AKI Consortium. A genome-wide association study to

identify single nucleotide polymorphisms for acute kidney injury. Am J Respir Crit Care Med 195:482-490,

2017.

165. Famous, K., Delucchi, K., Ware, L.B., Kangelaris, K.N., Thompson, B.T., Matthay, M.A., Calfee, C.S..

ARDS subphenotypes respond differently to randomized fluid management strategy. Am J Respir Crit Care

Med, 195:331-8, 2017.

166. McKown, A.C., McGuinn, E., Ware, L.B., Wang, L., Janz, D.R., Rice, T.W., Semler, M.W.. Preadmission

oral corticosteroids are associated with reduced risk of acute respiratory distress syndrome in critically ill

adults with sepsis. Crit Care Med, 45:774-80, 2017.

167. Polosukhin, V.V, Richmond, B.W., Du, R.-H. Massion, P.P., Ware, L.B., Lee, J.W., Kononov, A.V., Lawson,

W.E., Blackwell, T.S.. SIgA deficiency in individual small airways is associated with persistent inflammation

and remodeling. Am J Respir Crit Care Med, 195:1010-1021, 2017.

168. Luo, L., Shaver, C.M., Zhao, Z., Koyama, T., Calfee, C.S., Bastarache, J.A, Ware, L.B.. Clinical predictors

of hospital mortality differ between direct and indirect acute respiratory distress syndrome. Chest, 151:755-63,

2016.

169. Shaver, C.M., Clune, J.K., Grove, B.S., Wickersham, N.E., Ware, L.B., Bastarache, J.A.. Higher levels of

circulating microparticle levels are reduced in patients with ARDS. Critical Care, 21:120 2017.

170. Rogers, A.J., Contrepois, K., Wu, M., Zheng, M., Peltz, G., Ware, L.B., Matthay, M.A.. Profiling of ARDS

pulmonary edema fluid identifies a metabolically distinct subset. Am J Physiol Lung Cell Mol Physiol

312:L703-9, 2017.

171. Zhao, Z., Wickersham, N., Kangelaris, K.N., May, A.K., Bernard, G.R., Matthay, M.A., Calfee, C.S, Koyama,

T., Ware, L.B.. External validation of a biomarker and clinical prediction model for hospital mortality in

acute respiratory distress syndrome. Intensive Care Med 43:1123-31, 2017.

Journal Articles in Press:

1. Long, J., Zheng, N.S., Bastarache, L.A., Bastarache, J.A., Lu, Y., Ware, L.B., Shu, X.O., Denny, J.C. A

common deletion in the haptoglobin gene associated with blood cholesterol levels among Chinese women. In

press, J Hum Genetics. May 2017.

2. Ware, L.B., Zhao, Z., Koyama, T., Brown, R.M., Semler, M.W., Janz, D.R., May, A.K., Fremont, R.D.,

Matthay, M.A., Cohen, M.J., Calfee, C.S.. Derivation and validation of a two-biomarker panel for diagnosis

of ARDS in patients with severe traumatic injuries. Trauma Acute Care Surg Open. In press, 2017.

3. Porteous, M.K., Lee, J.C., Lederer, D., Palmer, S.M., Cantu, E., Shah, R.J., Bellamy, S.L., Lama, V., Bhorade,

S.M., Crespo, M.M., Wille, K.M., Localio, A.R., Orens, J.B., Shah, P.D., Weinacker, A.D., Arcasoy, S.,

Wilkes, D.S., Ware, L.B., Christie, J.D., Kawut, S.M., Diamond, J.M., for the Lung Transplant Outcomes

Group. Clinical Risk Factors and Prognostic Model for Primary Graft Dysfunction after Lung Transplantation

in Patients with Pulmonary Hypertension. Ann Am Thorac Soc. In press, 2017.

4. DesPrez, K., McNeil, J.B., Wang, C., Bastarache, J.A., Shaver, C.M., Ware, L.B.. Oxygenation saturation

index predicts clinical outcomes in ARDS. Chest. In press, 2017.

5. McKown, A.C., Brown, R.M., Ware, L.B., Wanderer, J.P.. External validity of electronic sniffers for

automated recognition of acute respiratory distress syndrome. J Intensive Care Med. In press, 2017.

Journal Articles Submitted:

1. Brown, A.M., Chipps, T.M., Gebretsadik, T., Ware, L.B., Islam, J., Hartert, T.V.. Vanderbilt Medical

Scholars Program: Training the Next Generation of Physician Researchers. Submitted, 2017.


37

2. Annane, D., Mira, J.P., Ware, L.B., Gordon, A.C., Hinds, C., Christiani, D., Sevransky, J., Barnes, K.,

Buchman, T.G., Heagerty, P.J., Balshaw, R., Lesnikova, N., de Nobrega, K., Wellman, H.F., Neira, M.,

Mancini, A.D.J., Walley, K.R., Russell, J.A.. Pharmacogenomic biomarkers do not predict response to

drotrecogin alfa (activated) in patients with severe sepsis. Submitted, 2017.

3. Stapleton, R.D., Suratt, B.T., Neff, M.J., Wurfel, M.M., Ware, L.B., Ruzinski, J.T., Caldwell, E., Hallstrand,

T.S., Parsons, P.E.. Bronchoalveolar fluid and plasma inflammatory biomarkers in contemporary patients with

acute respiratory distress syndrome. Submitted, 2017.

4. Rogers, A.J., Solus, J., Hunninghake, G.M., Baron, R.M., Schwartz, D.A., May, A.K., Lawson, W.E.,

Blackwell, T.S., Ware, L.B.. MUC5B promotor polymorphism and development of ARDS. Submitted, 2017.

5. Harbron, C., Liptrot, T., Jenkins, S., Huang, X., Schmitt, N., Lindemann, J., Ware, L.B., Holland, R., Bernard,

G.R.. Prognostic biomarkers of sepsis outcome in a Phase IIb study of AZD9773 in adult patients with severe

sepsis and/or septic shock. Submitted 2017.

6. Diamond, J.M., Chang, B.-L., Rushefski, M., Meyer, N.J., Feng, R., Kawut, S.M., Copeland, A.F., Lederer,

D.J., Shah, R., Cantu, E., Lama, V.N., Bhorade, S., Crespo, M., Wille, K., Orens, J., Shah, P.D., Weinacker, A.,

Arcasoy, S., Wilkes, D., Reynolds, J.M., Ware, L.B., Olthoff, K.M., Meyer, K., Emond, J., Shaked, A.,

Palmer, S. M., Christie, J.D. for the Lung Transplant Outcomes Group and the Clinical Trials in Organ

Transplantation-03 Investigators. TLR4 variation and gene expression alter risk of primary graft dysfunction

in lung transplant recipients. Submitted, 2017.

7. Shah, R.J., Rothaar, K., Emtiazjoo, A., Frye, S., Diamond, J.M., Cantu III, E., Lederer, D.J., Lama, V.N.,

Orens, J., Shah, P., Weinacker, A., Dhillon, G., Bhorade, S., Wille, K.M., Ware, L.B., Palmer, S.M., Snyder,

L., Hartwig, M., Crespo, M., McDyer, J., Wilkes, D.S., Christie, J.D.. The role of antibodies to collagen V in

the development of primary graft dysfunction after lung transplantation. Submitted, 2017.

8. Toki, S., Goleniewska, K., Reiss, S., Zhang, J., Bloodworth, M.H., Stier, M.T., Zhou, W., Newcomb, D.C.,

Ware, L.B., McKenzie, A.N.J., Stanwood, G.D., Galli, A., Boyd, K.L., Niswender, K.D., Peebles, R.S..

Glucagon-like peptide 1 receptor agonist, liraglutide inhibits allergen-induced IL-33 release and reduces group

2 innate lymphoid cell (ILC2) cytokine production in vivo. Submitted, 2017.

9. Putz, N.D, Shaver, C.M., Dofu, K., Li, C.-M., Xu, Q., Hutchaleelaha, A., Lehrer-Graiwer, J., Ware, L.B.,

Bastarache, J.A.. GBT1118, a compound that increases the oxygen affinity of hemoglobin, improves survival

in murine hypoxic acute lung injury. Submitted, 2017.

10. Warren, M.A., Zhao, Z., Koyama, T., Bastarache, J.A., Shaver, C.M., Semler, M.W., Rice, T.W., Matthay,

M.A., Calfee, C.S., Ware, L.B.. Radiographic assessment of lung edema: association with clinical outcomes

and response to fluid treatment in ARDS. Submitted, 2017.

11. Murphy, L.S., Wickersham, N., McNeil, J.B., Shaver, C.M., May, A.K., Bastarache, J.A., Ware, L.B..

Endothelial glycocalyx degradation is more severe in patients with non-pulmonary sepsis compared to

pulmonary sepsis and associates with risk of ARDS and other organ dysfunction. Submitted, 2017.

12. Leaf, D.E., Siew, E., Eisenga, M.F., Singh, K., McCausland, F.R., Srivastava, A., Ikizler, T.A., Ware, L.B.,

Ginde, A.A., Kellum, J.A., Palevsky, P.M., Wolf, M., Waikar, S.S.. Fibroblast growth factor 23 and mortality

among critically ill patients. Submitted, 2017.

13. Hamilton, B., Liu, K., Segal, M., Johansen, K., Ware, L.B., Thompson, B.T., Kukreja, J., Matthay, M.A.. A

parsimonious model combining biologic and clinical variables to predict mortality in septic shock. Submitted,

2017.

14. Cantu, E., Diamond, J.M., Suzuki, Y., Lasky, J., Schaufler, C., Lim, B., Shah, R., Porteous, M., Lederer, D.J.,

Kawut, S.M., Palmer, S.M., Snyder, L., Hartwig, M.G., Lama, V.N., Bhorade, S., Bermudez, C., Crespo, M.,

McDyer, J., Wille, K., Orens, J., Shah, P.D., Weinacker, A., Weill, D., Wilkes, D., Roe, D., Hage, C., Ware,

L.B., Bellamy, S.L., Christie, J.D., for the Lung Transplant Outcomes Group. Quantitative evidence for

revising the definition of primary graft dysfunction following lung transplantation. Submitted, 2017.

15. Diamond, J.M., Ramphal, K., Porteous, M.K., Cantu, E., Crespo, M., Lederer, D.J., Arcasoy, S., Lama, V.N.,

Bhorade, S., McDyer, J., Wille, K., Shah, R.J., Singer, J.P., Shah, P.D., Orens, J., Weinacker, A., Hage, C.,

Palmer, S.M., Snyder, L., Ware, L.B., Christie, J.D., Kawut, S.M., for the Lung Transplant Outcomes Group.


38

Association of long pentraxin 3 with pulmonary hypertension and PGD in lung transplant recipients.

Submitted, 2017.

16. McNeil, J.B., Shaver, C.M., Russell, D., Grove, B.S., Warren, M.A., Wickersham, N.E., Ware, L.B.,

McDonald, W.H., Bastarache, J.A.. Novel method for non-invasive sampling of the distal airspace in acute

respiratory distress syndrome. Submitted, 2017.

17. Shaver, C.M., Wickersham, N., McNeil, J.B., Nagata, H., Miller, A., Landstreet, S.R., Kuck, J.L., Diamond,

J.M., Lederer, D.J., Kawut, S.M., Palmer, S.M., Wille, K.M., Weinacker, A., Lama, V.N., Crespo, M., Orens,

J.B., Shah, P.D., Hage, C.A., Cantu, E. Porteous, M.K., Dhillon, G., McDyer, J., Bastarache, J.A., Christie,

J.D., Ware, L.B., and the Lung Transplant Outcomes Group. Plasma cell-free hemoglobin and risk of primary

graft dysfunction after lung transplantation: mechanisms and clinical implications. Submitted, 2017.

Invited Reviews, Case Reports, Letters, Editorials:

1. Ware, L.B., Keith, F.M., Gordon, R.L., Ries, C.A., Seitz, R.F., Mitchell, E.J., Gold, W.M., Golden, J.A. Lung

transplantation for pulmonary amyloidosis: A case report. J. Heart Lung Transplant. 17:1129-1132, 1998.

2. Matthay, M.A., Flori, H.R., Conner, E.R., Ware, L.B. Alveolar epithelial fluid transport: Basic mechanisms

and clinical relevance. Proc. Assoc. Am. Phys. 110:496-505, 1998.

3. Ware, L.B., Matthay, M.A. Medical progress: The acute respiratory distress syndrome. N. Engl. J. Med.

342:1334-1349, 2000.

4. Brower, R.G., Ware, L.B., Berthiaume, Y., Matthay, M.A. Treatment of ARDS. Chest120:1347-1367, 2001.

5. Ware, L.B. Managing death in the intensive care unit: the transition from cure to comfort. [Book Review]. N.

Engl. J. Med. 346:542, 2002.

6. Ware, L.B., Matthay, M.A. Keratinocyte and hepatocyte growth factors in the lungs: roles in lung

development, inflammation, and repair. Am. J. Physiol.: Lung Cell Mol. Physiol. 282:L924-L940, 2002.

7. Matthay, M.A., Bhattacharya, S., Gaver, D., Ware, L.B., Lim, L., Syrkina, O., Eyal, F., Hubmayr, R.

Ventilator-induced lung injury: in vivo and in vitro mechanisms. Am. J. Physiol.: Lung Cell Mol. Physiol.

283(4):L678-L682, 2002.

8. Ware, L.B., Matthay, M.A. Measuring microvascular blood flow in sepsis--a continuing challenge. Lancet

360(9341)1187-1188, 2002.

9. Ware, L.B. Advances in the pathogenesis and treatment of the acute respiratory distress syndrome. Clin. Pulm.

Med. 10(4):208-218, 2003.

10. Ware, L.B. Modulation of alveolar fluid clearance by acute inflammation--the plot thickens. Am. J. Respir.

Crit. Care Med. 169:332-333, 2004.

11. Matthay, M.A., Ware, L.B. Plasma protein C levels in patients with Acute Lung Injury: prognostic

significance. Crit. Care Med. 32(5):S229-S232, 2004.

12. Prudhomme, J.B., Ware, L.B. Potential new pharmacologic therapies for acute lung injury and the acute

respiratory distress syndrome. Drug Discovery Today: Disease Mechanisms 1(1):123-128, 2004.

13. Nathens, A.B., Curtis, J.R., Beale, R.J., Cook, D.J., Moreno, R.P., Roman, J-A., Skerrett, S.J., Stapleton, R.D.,

Ware, L.B., Waldmann, C.S. Management of the critically ill patient with severe acute pancreatitis. Crit. Care

Med. 32(12):2524-2536, 2004

14. Matthay, M.A., Ware, L.B. Can nicotine treat sepsis? Nat. Med. 10(11):1161-1162, 2004.

15. Ware, L.B. Keratinocyte growth factor as an epithelial protective agent: where do we stand? Intl. J. Rad. Onc.

Biol. Phys. 60:1345-1346, 2004.

16. Nathens, A.B., Curtis, J.R., Beale, R.J., Cook, D.J., Moreno, R.P., Romand, J.A., Skerrett, S.J., Stapleton, R.D.,

Ware L.B., Waldmann, C.S. Executive summary: management of the critically ill patient with severe acute


39

pancreatitis. Proc. Am. Thorac. Soc. (4):289-290, 2004.

17. Ware, L.B. Prognostic determinants of ARDS in adults: Impact on clinical trial design. Crit. Care Med.

33(3):S217-S222, 2005.

18. Fussell, K.M., Awad, J.A., Ware, L.B. A case of fulminant hepatic failure due to unrecognized peripartum

cardiomyopathy. Crit. Care Med. 33:891-893, 2005.

19. Arcasoy, S.M., Fisher, A., Hachem, R.R., Scavuzzo, M., Ware, L.B. Report of the ISHLT Working Group on

Primary Graft Dysfunction. Part V: Predictors and Outcomes. J. Heart Lung Transplant. 24:1483-1488, 2005.

20. Ware, L.B., Bastarache, J.A., Wang, L. Coagulation and fibrinolysis in human acute lung injury--new

therapeutic targets? Keio J. Med. 4:142-149, 2005.

21. Ware, L.B., Matthay, M.A. Clinical Practice: Acute Pulmonary Edema. N. Engl. J. Med. 353:278-296, 2005.

22. Fussell, K.M., Ware, L.B.. Unrecognized peripartum cardiomyopathy. Crit. Care Med. 33(8):1893, 2005.

23. Rice, T.W., Ware, L.B. Clinical trial design in ARDS: facing down the complexity. J. Crit. Care 21:32-37,

2006.

24. Matthay, M.A., Christman, J.W., Pitt, B.R., Schwiebert, L.M., Stevens, T., Ware, L.B. Perspectives,

translational research and letters to the editor. Am. J. Physiol.: Lung Cell. Mol. Physiol. 290(4):L621, 2006.

25. Wardwell, N.R., Miller, R., Ware, L.B. Pulmonary alveolar proteinosis associated with a disease modifying

antirheumatoid arthritis drug. Respirology 11(5):663-665, 2006.

26. Bastarache, J.A., Wang, L., Ware, L.B. The role of coagulation and fibrinolysis in the pathogenesis of acute

lung injury. Current Respiratory Medicine Reviews 2:157-171, 2006

27. Sapru, A., Wiemels, J.L., Witte, J.S., Ware, L.B., Matthay, M.A. Acute lung injury and the coagulation

pathway: potential role of gene polymorphisms in the protein C and fibrinolytic pathways. Intensive Care Med.

32(9):1293-1303, 2006.

28. Matthay, M.A., Christman, J.W., Pitt, B.R., Schwiebert, L.M., Stevens, T., Ware, L.B. A new era of

opportunities in lung research. Am. J. Physiol.: Lung Cell. Mol. Physiol. 290(1):L1, 2006.

29. Ware, L.B. Pathophysiology of acute lung injury and the acute respiratory distress syndrome. Semin. Respir.

Crit. Care Med. 27(4):337-349, 2006.

30. Bastarache, J.A., Ware, L.B., Bernard, G.R. The role of the coagulation cascade in the continuum of sepsis

and ALI/ARDS. Semin. Respir. Crit. Care Med. 27(4):365-376, 2006.

31. Ware, L.B., Camerer E, Welty-Wolf, K., Schultz, M., Matthay, M.A. Bench to Bedside: Targeting coagulation

and fibrinolysis in acute lung injury. Am. J. Physiol: Lung Cell. Molec. Physiol. 291(3):L354-L361, 2006.

32. Calfee, C.S., Ware, L.B. Biomarkers of lung injury in primary graft dysfunction following lung

transplantation. Biomarkers in Medicine. 1(2):285-291, 2007.

33. Raj, U., Aliferis, C., Caprioli, R., Cowley Jr., A., Davies, P., Duncan, M., Erle, D., Erzurum, S.C., Finn, P.,

Ischiropoulos, H., Kaminski, N., Kleeberger, S., Leikauf, G., Loyd, J., Martin, T., Matalon, S., Moore, J.,

Quackenbush, J., Sabo-Attwood, T., Ware, L.B., Matthay, M.A.. Genomics and Proteomics of Lung Disease:

Conference Summary. Am. J. Physiol. Lung Cell. Mol. Physiol. 293:L45-51, 2007.

34. Ware, L.B. Clinical Year in Review III. Asthma, lung transplantation, cystic fibrosis and ARDS. Proc. Am.

Thorac. Soc. 4:489-93, 2007.

35. Tino, G., Ware, L.B., Moss M. Clinical Year in Review IV. Chronic obstructive pulmonary disease,

nonpulmonary critical care, diagnostic imaging and mycobacterial disease. Proc. Am. Thorac. Soc. 4:494-8,

2007.

36. Girard T.D., Ware, L.B.. Biomarkers of cardiac injury in acute respiratory distress syndrome: Getting to the

heart of the matter. Crit Care Med. 35:2638-2639, 2007.

37. Fremont, R.D., Ware,L.B., Kallet, R.H., Matthay, M.A. Response to Postobstructive Pulmonary Edema; a

case for hydrostatic mechanisms. Chest 132(6);2057, 2007.


40

38. Ware, L.B.. Modeling human lung disease in animals. Am. J. Physiol. Lung Cell. Mol. Physiol. 294: L149-

L150, 2008.

39. Gerszten, R.E., Accurso, F., Bernard, G.R., Caprioli, R.M., Klee, E.W., Klee, G.G., Kullo, I., Roth, F.P.,

Sabatine, M., Srinivas, P., Wang, T.J., Ware, L.B. for the NHLBI Clinical Proteomics Programs. Challenges

in Translating Proteomic Technologies from Bench to Bedside: Update from the NHLBI Clinical Proteomics

Programs. Am. J. Physiol. Lung Cell Mol. Physiol. 295:L16-L22, 2008.

40. Wang L., Bastarache J.A., Ware L.B. The Coagulation Cascade in Sepsis. Curr. Pharm. Design 14:1860-1869,

2008.

41. Ware, L.B. Clinical year in review IV: Acute Respiratory Syndrome, Radiology in the Intensive Care Unit,

Nonpulmonary Critical Care and Pulmonary Infections in the Immunocompromised Host. Proc. Am. Thorac.

Soc. 5(7):755-760, 2008.

42. Moss M., Wilkes, D., Ware, L.B. Clinical Year in Review II: Pulmonary Infections in the Immunocompetent

Host, Issues in the Training of Fellows and Residents, Asthma, and Chronic Obstructive Pulmonary Disease.

Proc. Am. Thorac. Soc. 5(7):745-750, 2008.

43. Ware, L.B., Matthay, M.A. Beyond Fishing: The role of discovery proteomics in mechanistic lung research.

Am. J. Physiol. Lung Cell. Mol. Physiol. 296:L12-3, 2009.

44. Levitt, J.E., Gould, M.K., Ware, L.B., Matthay, M.A.. The pathogenetic and prognostic value of biologic

markers in acute lung injury. J. Intensive Care Med. 24:151-67, 2009.

45. Ware, L.B., Eisner, M.D., Flaherty, K. Clinical Year in Review II. Sepsis, mechanical ventilation,

occupational/environmental lung disease, sleep. Proc. Am. Thorac. Soc. 15:494-9, 2009.

46. Ware, L.B. Clinical Year in Review I. Interstitial lung disease, pulmonary vascular disease, pulmonary

infections and cardiopulmonary exercise testing and pulmonary rehabilitation. Proc. Am. Thorac. Soc. 15:487-

93, 2009.

47. Spragg, R.G., Bernard, G.R., Checkley, W., Curtis, J.R., Gajic, O., Guyatt, G., Hall, J., Israel, E., Jain, M.,

Needham, D., Randolph, A., Rubenfeld, G., Schoenfeld, D., Thompson, B.T., Ware, L.B., Young, D., Harabin,

A.L. Beyond Mortality: Future clinical research in acute lung injury: An NHLBI workshop report. Am. J.

Respir. Crit. Care Med. 181:1121-7, 2010.

48. Ware, L.B., Summar, M.L. Understanding the role of NOS-3 in ventilator - induced lung injury – Don’t take

NO for an answer. Am. J. Physiol. Lung Cell. Mol. Physiol. 299:L147-9, 2010.

49. Siew, E.D., Ware, L.B., Ikizler, T.A. Biological markers of acute kidney injury. J. Amer. Soc. Nephrol. 2011;

22:810-20.

50. Rey. M.M, Ware, L.B., Matthay, M.A., Bernard, G.R., McGuire, A.L., Caplan, A.L., Halpern, S.D. Informed

consent in research to improve the number and quality of deceased donor organs. Crit. Care Med. 39:280-3,

2011.

51. Barnett, N., Ware, L.B. Biomarkers in acute lung injury – Marking forward progress. Crit. Care Clin. 27:

661-83, 2011.

52. Pitt, B.R., Christman, J.W., Gunst, S.J., Matthay, M.A., Stevens, T., Ware, L.B. Physiology, reductionism and

translational medicine: The right mix. Am. J. Physiol. Lung Cell, Mol. Physiol. 301:L389-90, 2011.

53. Sebag, S.C., Bastarache, J.A., Ware, L.B. Therapeutic modulation of coagulation and fibrinolysis in acute lung

injury and acute respiratory distress syndrome. Curr Pharm. Biotech. 12:1481-96, 2011.

54. Ware, L.B., Girard, T. Acute lung injury: Surprisingly common in the Neuro ICU. Crit. Care Med. 40:694-5,

2012.

55. Tonelli, M., Curtis, J.R., Guntupalli, K., Rubenfeld, G., Arroliga, A., Brochard, L., Douglas, I., Gutterman, D.,

Hall, J., Davanagh, B., Mancebo, J., Misak, C., Simpson, S., Slutsky, A., Suffredini, A., Thompson, B.T.,

Ware, L.B., Wheeler, A., Zacharias, E., Levy, M. The role of clinical research results in the practice of critical

care medicine. An Official Multi-Society Statement: Am J Respir Crit Care Med. 185:1117-1124, 2012.


41

56. Matthay, M.A., Ware, L.B., Zimmerman, G.A. The acute respiratory distress syndrome. J. Clin. Invest.

122:2731-40, 2012.

57. Wilcox, M.E., Rivera, M.P., Sassoon, C., Ware, L.B., Wunsch, H., Herridge, M.S. Clinical Year in Review II.

Mechanical ventilation, acute respiratory distress syndrome, critical care and lung cancer. Proc. Am. Thorac.

Soc. 9:190-6, 2012.

58. Janz, D.R., Ware, L.B. Biomarkers of ALI/ARDS: pathogenesis, discovery, and relevance to clinical trials.

Semin Respir Crit Care Med. 34:537-48, 2013.

59. Ware, L.B. Acute Respiratory Distress Syndrome: From TRALI to trials. Lancet Respir. Med. 1: e1, 2013.

60. Ware, L.B. Autopsy in ARDS: insights into natural history. Lancet Respir Med 1:352-354, 2013.

61. Janz, D.R., Ware, L.B. The authors reply. Crit Care Med 41: e186, 2013.

62. Ware, L.B., Herridge, M.. Acute lung injury. Semin Respir Crit Care Med. 34, 439-40, 2013.

63. Janz, D.R., Ware, L.B.. The needle in the haystack: searching for biomarkers in acute respiratory distress

syndrome. Crit Care 17:192, 2013.

64. Janz, D.R., Ware, L.B.. Plasma biomarkers in acute respiratory distress syndrome. A work in progress. Crit

Care Med. 42:755-6, 2014.

65. Bastarache, J.A., Roberts, L.J. II, Ware, L.B.. Thinking outside the cell: how cell-free hemoglobin can

potentiate acute lung injury. Am. J. Physiol. Lung Cell. Mol. Physiol. 306:L231-2, 2014.

66. Janz, D.R., Ware, L.B.. Approach to the patient with the acute respiratory distress syndrome. Clin. Chest

Med., 35: 685-96, 2014.

67. Walter, J.M., Wilson, J., Ware, L.B. Biologic markers in acute respiratory distress syndrome: from

pathobiology to improving patient care. Expert Rev. Respir. Med. 8:573-86, 2014.

68. Ware, L.B.. Transfusion-induced lung endothelial injury: a DAMP death? Am. J. Respir. Crit. Care Med.

190:1331-2, 2014.

69. Walter, J., Ware, L.B., Matthay, M.A.. Mesenchymal stem cells: mechanisms of potential therapeutic benefit

in ARDS and sepsis. Lancet Respir. Med. 2:1016-26, 2014.

70. Ware, L.B., Bastarache, J.A., Calfee, C.S.. ARDS: New mechanistic insights, new therapeutic directions.

Clin. Chest Med. 35: xv-xvi, 2014.

71. Chen, W., Ware, L.B.. Prognostic factors in the acute respiratory distress syndrome. Clin Transl. Med.; 4:65,

2015.

72. Bastarache, J.A., Wynn, J.L., Ware, L.B.. Fanning the fire: can methemoglobin enhance neutrophil activation?

EBioMedicine; 2: 184-5, 2015.

73. Matthay, M.A., Ware, L.B.. Resolution of alveolar edema in ARDS – Physiology and biology. Am. J. Respir.

Crit. Care Med. 192:124-5, 2015.

74. Janz, D.R., Ware, L.B.. The role of red blood cells and cell-free hemoglobin in the pathogenesis of ARDS. J.

Intens. Care Med. 3:20, 2015.

75. Meksonto Dessap, A., Bouadma, L., Ware, L.B.. What’s new with biomarker-driven clinical strategy in sepsis

and circulatory failure? Intens. Care Med. 42: 418-21, 2016.

76. Ware, L.B., Calfee, C.S.. Biomarkers of ARDS: what’s new? Intensive Care Med 42: 797-9, 2016.

77. Meksonto Dessap, A., Ware, L.B., Bagshaw, S.M.. How could biomarkers of ARDS and AKI drive clinical

strategies? Intens Care Med. 42:800-2, 2016.

78. Bhattacharya, M., Kallet, R., Ware, L.B., Matthay, M.A.. Negative pressure pulmonary edema. Chest 150:

927-33, 2016.

79. McKown, A.C., Ware, L.B.. Quantification of lung recruitment by respiratory mechanics and CT imaging:

what are the clinical implications? Ann Transl Med 4:145, 2016.


42

80. Hamilton B.C.S., Kukreja J., Ware L.B., Matthay M.A.. Protein biomarkers associated with primary graft

dysfunction following lung transplantation. Am J Physiol Lung Cell Mol Physiol 312:L531-41, 2017.

81. Shaver, C.M., Ware, L.B.. Primary graft dysfunction: pathophysiology to guide new preventive therapies.

Exp Rev Respir Med. 11:119-128, 2017.

82. Mehta, S., Burns, K.E.A., Machado, F.R., Fox-Robichaud, A.E., Cook, D.J., Calfee, C.S., Ware, L.B.,

Burnham, E.L., Kissoon, N., Marshall, J.C., Mancebo, J., Finfer, S., Hartog, C., Reinhart, K., Maitland, K.,

Stapleton, R.D., Kwizera, A., Amin, P., Abroug, F., Smith, O., Laake, J.H., Shrestha, G.S., Herridge, M.S..

Gender parity in critical care medicine. Am J Respir Crit Care Med, in press, 2017.

83. Ware, L.B.. Biomarkers in critical illness: challenges and future directions. Am J Respir Crit Care Med, in

press, 2017.

84. Matthay, M.A., McAuley, D.F., Ware, L.B.. Clinical trials in acute respiratory distress syndrome: challenges

and opportunities. Lancet Respir Med 5:524-34, 2017.

Books and Book Chapters:

1. Berthiaume, Y., Ware L.B. and Matthay, M.A. Treatment of acute pulmonary edema and the acute respiratory

distress syndrome. In: Pulmonary Edema. M.A. Matthay, D.H. Ingbar, eds.; C. Lenfant, series editor. Lung

Biology in Health and Disease, Volume 116. Marcel Dekker, New York, 1998, pp. 575-631.

2. Matthay, M.A., Conner, E.R., Ware, L.B., Verghese, G. Biological markers of acute lung injury. In: Acute

Respiratory Distress Syndrome: Cellular and Molecular Mechanisms and Clinical Management. S Matalon, J.I.

Sznajder, eds., Plenum Publishing, New York, 1998, pp. 207-214.

3. Ware, L.B., Matthay, M.A. Acute hypoxemic respiratory failure. In: Chest Medicine: Essentials of Pulmonary

and Critical Care Medicine. R.B. George, R.W. Light, M.A. Matthay, R.A. Matthay, eds., Lippincott Williams

and Wilkins, Media, PA, 2000, pp. 576-591.

4. Ware, L.B., Matthay, M.A. Biological markers of acute lung injury. In: Etiology and Treatment of Acute Lung

Injury: From Bench to Bedside. S. Matalon, J.I. Sznajder, eds., Plenum Publishing, NY, pp. 103-112, 2001.

5. Matthay, M.A., Ware, L.B., Frank, J.A. Pulmonary epithelial injury: Clinical and experimental evidence for a

major role in acute lung injury and multiorgan dysfunction. In: Mechanisms of Organ Dysfunction in Critical

Illness. T.W. Evans, M.P. Fink, eds.; J-L. Vincent, series editor. Update in Intensive Care and Emergency

Medicine, Vol. 38, Springer-Verlag, 2002, pp. 222-226.

6. Ware, L.B., Evans, T.W. Pathogenesis of acute lung injury. In: Acute Respiratory Distress Syndrome. M.A.

Matthay, ed., C. Lenfant, series ed.: Lung Biology in Health and Disease, Marcel Dekker, NY, 2003, pp. 147-

180.

7. Ware, L.B. Severe acute respiratory syndrome (SARS). In: Acute Respiratory Distress Syndrome. M.A.

Matthay, ed., C. Lenfant, series ed.: Lung Biology in Health and Disease, Marcel Dekker, NY, 2003, pp. 633-

644.

8. Ware, L.B., Matthay, M.A. Acute hypoxemic respiratory failure. In: Chest Medicine: Essentials of Pulmonary

and Critical Care Medicine, 5th ed. R.B. George, R.W. Light, R. A. Matthay, M.A. Matthay, eds., Lippincott,

Williams & Wilkins, 2005, pp. 549-563.

9. Ware, L.B., Bernard, G.R. Acute lung injury and the Acute Respiratory Distress Syndrome. In: Textbook of

Critical Care, 5th edit., Fink, M.P., Abraham, E., Kochanel, P.M., Vincent, J-L., eds., Elsevier Science,

Philadelphia, 2005, pp. 571-579.

10. Covarrubias, M.B., Ware, L.B. Pulmonary edema in organ donors and lung transplant recipients: Is there a

role for beta-adrenergic agonists? 2006 Yearbook of Intensive Care and Emergency Medicine. J.L. Vincent,

edit., Springer-Verlag, 2006, pp. 366-373.

11. [Contributor] What's Past is Prologue, a book of personal essays about women in academic medicine. EG

Neilson, ed., Hillsboro Press, Franklin, Tennessee, 2006, pp. 69-74.

12. Hirsch, J., Ware, L.B., Matthay, M.A. Pulmonary proteomics. In: Clinical Proteomics: From Diagnosis to

Therapy, J. Van Eyk, M.J. Dunn, eds. Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany, 2008,


43

pp.323-347.

13. Ware, L.B., Matthay, M.A. Resolution of Alveolar Edema. Mechanisms and Relationship to Clinical Acute

Lung Injury. In: Acute Respiratory Distress Syndrome, 2nd

Ed. A. Choi, ed., InForma HealthCare, New York,

2010, pp. 237-261.

14. O’Neal H.R., Ware L.B. What is the natural history of a patient with ARDS? In: An Evidence Based Practice

of Critical Care. C.S. Deutschman, P. Neligan, eds., Saunders Elsevier; Philadelphia, PA, 2010, pp. 68-72.

15. Bastarache, J.A., Ware, L.B., Bernard, G.R. Acute lung injury and the acute respiratory distress syndrome.

In: Textbook of Critical Care, 6th

edit., Fink, M.D., Abraham, E., Kochanek, P.M. Vincent, J.-L., eds., Elsevier

Science, Philadelphia, 2011, pp. 388-97.

16. Ware, L.B. Pathophysiology of the Acute Respiratory Distress Syndrome. In: Oxford Textbook of Critical

Care, 2nd

edit. Webb, A., Angus, D.C., Finfer, S., Gattinoni, L., Singer, M., eds., Oxford University Press, New

York, 2016, pp. 497-500.

17. Ware, L.B., Bastarache, J.A., Bernard, G.R.. Acute respiratory distress syndrome. In: Textbook of Critical

Care, 7th

edit.. Vincent., J.-L., Abraham, E., Kochanek, P., Moore, F., Fink, M., eds., Elsevier, Philadelphia,

PA, 2017, pp 413-24.

18. Matthay, M.A., Ware, L.B.. Acute respiratory failure. In: Goldman-Cecil Medicine, 26th

Edition. Goldman,

L., Schafer, A., Eds. Elevier, Philadelphia, PA. In press, 2017.

Electronic Media

1. Ware, L.B. Acute Respiratory Distress Syndrome. BMJ Best Practice online reference

(http://bestpractice.bmj.com/best-practice/monograph/374.html). Last updated 8-09-16.

Abstracts – Available on request.

Documents

LORRAINE B. WARE, MD · CURRICULUM VITAE LORRAINE B. WARE, MD Date of Birth: November 26, 1966 San Diego, California Business Address: Center for Lung Research T-1218 Medical Center