Liver histology

Dr. Kashif Asghardrkashifasghar@gmail.com

1. portal triad 2. lobule 3. central vein 4. bile canaliculi 5.common bile duct 6. hepatic portal vein 7. hepatic artery

8. hepatocyte plate (with hepatocytes) 9.sinusoids

Functional organization of liver• Periportal: High respiratory

enzyme activity & glutathione contents. Take up more bile acid & secrete more bile constituents. Detoxification of ammonia to urea.

• Midzonal region: High regenerative activity

• Centrilobular: High concentration of P450 enzyme & low concentration of glutathione.

MID ZONAL

Periportal

Centrilobular

Liver 10x

Liver is divided histologically into lobules. The center of the lobule is the central vein. At the periphery of the lobule are portal triads. Functionally, the liver can be divided into three zones, based upon oxygen supply. Zone 1 encircles the portal tracts where the oxygenated blood from hepatic arteries enters. Zone 3 is located around central veins, where oxygenation is poor. Zone 2 is located in between.

Liver 40x

Hepatocellular carcinoma