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Islet cellsecretinghormones
Cells secretingpancretic juice
Insulin and glucagon
Pancreticduct
Duodenum
Pancreas
Common bile duct
Blood
Pancreatic Anatomy
Pancreatic Secretions
• Acinar Enzymes Digestion
• Ductal HCO3 and Water Protection Digestion
Cell Type Component Function:
ATP
cAMP
Adenyl cyclase
?
?Ca2+
Ca2+
stores
Secretin
Ach
CCK
En
zymes
IP3
The Hormones also Modulate Enzyme Expression
Primary Stimulus
PANCREATIC ACINAR CELL
Regulators of Pancreatic Secretion
• Acinar CCK / Ach Secretin
• Ductal Secretin CCK / Ach
Cell Type PrimaryActivator Potentiator
(Ca2+ )
(cAMP )
Cephalic and Gastric: Neural – Ach
Intestinal : Hormonal
Liver
HepaticDucts
Right
Left
Common BileDuct
Cystic Duct
GallbladderAmpulla
ofVater
DuodenalLumen
PancreaticDuct
Sphincterof Oddi
• Excretory Component - Bilirubin, Drug Metabolites.
• Secretory Component- Bile: Produced and Filtered by Hepatocytes
Primary Bile Acids: Cholic Acid, Chenodeoxycholic Acid
- Secondary Bile Acids - Formed by Bacteria in the Intestine
: Deoxycholic Acid, Lithocholic Acid
Bile AcidsPrimary bile acids Secondary bile acids
Cholesterol
Cholic acid Deoxycholic acid
Chenodeoxycholic acid
Lithocholic acid
Liver Intestine
Cholesterol 7-hydroxylase
80% 20%Fraction of Total
Amphipathic Carboxylic Acids
C
Have both Hydrophilic and Hydrophobic domains
Formation
of
Micelles
Co-Lipase
Bile Acids are Amphipathic
Centralvein
Hepatic cell plateBile canaliculus
Venous sinusoidTerminalbile duct
Kupffer cell
Portal venule
Aorta
(200)
Celiac(700)
PortalVein
Superior Mesenteric (700)
InferiorMesenteri
c (400)
LIVER
STOMACH
SPLEEN
PANCREAS
SMALLINTESTINE
COLON
To Systemic Circulation
(1800) mls/min
HEPATIC
Rates:
ml/min
Cholesterol 7-hydroxylase
Newly synthesizedbile acids(0.6 g/24 h)
Cholesterol
2 - 4 gbile-acid pool: circulated 6 - 10 times in 24 h
Excretedbile acids(0.6 g/24 h)
Liver
BileductsPortal
vein
ColonSmall intestine
Stomach
EnterohepaticCirculation
SECRETIONS of the INTESTINES
Information pertaining to the next 3
slides is found in the Lecture Notes for
the last Lecture
Blood vesselsLymph vesselsNervesSmooth muscleConnective tissuelymphocytesPlasma cellsEosinophiles
Villousepithelium
Undifferentiated
GobletMitoses
Endocrine cells
Cryptepithelium
Cryptlumen
Muscularismucosa
Absorp-tive cells
Gobletcells
Endocrine cells
Cell Loss
• Crypts of Lieberkuhn: Small and Large Intestine
- Contain Primarily Epithelial Cells, Mucus Goblet Cells, and Endocrine Cells.
- Water Secretion - VIP Activates Water Secretion by Elevating cAMP and Cl- conductance.
- Cell Growth and Differentiation: Cell Turnover at the Tip of a Villus is High (3-6 day Cycle).
Secretions of the Small Intestine (2000 ml/day)