8/8/2019 Liquid vs Lypholised Form

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SUPERIORITY OF SOLUTION FORM INTERFERON OVERLYOPHILIZED POWDERD.

Liquid Lyophilized/ Freeze dried Powder

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No chances of contamination as there isno reconstitution.

No re-mixing required thus no refoldingof protein chains.

Simple and easy to administration

No chances of mistakes,No inconsistent results,Less undesirable side effects

Surity of Quality is present as all the

manufacturing process is completedunder one roof and quality control,which is essential for biogenericproduct.

Chances of contamination due to due toreconstitution

Reconstitution products are avoided in formularies of Europe and USA because they have to pass throughtedious process of re-mixing. During mixing if proper care is not taken the protein chains of Interferon may remain without refolding due towhich the results may vary in the patients. It isbecause the refolding of chains is essential to bringthe desired therapeutic effects.

Difficult administration, these are even mentioned onthe leaf insert as well i.e. “The mixing of thesuspension should be made with gentle rotation, thevial containing the suspension should not be shakenvigorously”. But it is not done in reality. If you donotbelieve just give a surprise check to the staff that isinjecting the product.

Three big mistakes are done while injectinglyophilized forms

1) The water / solvent is directly sprayed on thepowder which is against preparationinstructions

2) The vial is not left idle so that the contents getmixed slowly

3) Vigorous shaking is done to mix the contents;this results in breaking of many proteinchains, which leads to inconsistent cure ratesand more side effects.

Actually two separate products are used in

lyophilized forms1) Interferon2) Water/solvent for injection

Both are separate pharmaceutical preparations andare not manufactured by the same Co. This is usuallypurchased from other companies; the quality controlmay differ and thus is the quality of the mixedproduct.

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Do you want to leave aside thesebenefits

• Simplicity in administration• Convenience• More Safety• Better Results

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Liquid form is the modern in which allthe original brands are available.

• Intron-A• Roferon• Pegasys etc

Original Brand is always superior • FDA Approved• Clinical data is regularly update

Thus the only way is to keep as close informulation to original brand aspossible. The closer you are toformulation, the closer you are to theresults of the original brand.INTEFEN is similar to the originalbrand in all aspects.

Do you want to buy for your patients:

• Complicated administration• Difficulty• More side effects• Inconsistent/bad results

Admix able products i.e. products containing twoseparate formulations

1) Lyophilized powder 2) Water/solvent for reconstitution

Is a primitive/discarded product form for interferon?The Original BRANDS are now available only inliquid forms. All have stopped manufacturing of the

powder and water combination Interferon.No bio similar product can claim superiority over theoriginal brand

• Not approved by FDA• Clinical data is not updated

Marked difference in formulation, marked differencein results

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When you want to treat patients in 2010 modern andeasy to administer forms are required which are easyto administer and patient compliance is at its best.