Lipid Metabolism

By

Amr S. Moustafa, M.D.; Ph.D.

Structure of common Lipid classes

Overview of lipid digestion

lipid metabolism:Hormonal control

Lipid absorption: Mixed micelle

Secretion of Lipids from Entrocytes as Chylomicron

Chylomicron Metabolism

Triacylglycerol synthesis and degradation

Production of cytosolic acetyl CoA

Acetyl Co A carboxylase: Allosteric regulation

Acetyl Co A carboxylase: Covalent modification

De novo synthesis of palmitate

Malic enzyme:NADPH production

The relation between glucose metabolism and palmitate synthesis

Pathways for Glycerphosphate Production

Synthesis of

Triacylglycerol

Common PrecursorFor

TG and PLSynthesis

Hormone-sensitive lipase: Hormonal regulation

Carnitine Shuttle

β-Oxidationof

Fatty Acid

Propionyl CoAMetabolism

Phytanic acid

Ketogenesis

KetolysisKetogenesis

Structure of someglycerophospholipids

Sphingomyelin

Phosphatidylcholinesynthesis

Intracellular Signaling by Inositol triphosphate

PI glycan membrane protein anchor

Phospholipases