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Online Resource 1Aligned sequences (PHYLIP format) of DNA polymerases using MUSCLE
78 7004Homo_alpha--------------------------------------------MAPVHGDD------SLSDSGSFVSSRARREKKSKKGRQEALERLKKAKAGEKYKYEVEDFTGVYEEVDEEQYSKLVQARQDDDWIVDDDGIGYVEDGREIFDDDLEDDALDADEKGKDGKARNKDKRNVKKLAVTKPNNIKSMFIACAGKKTADKAVDLSKDGLLGDILQDLNTETPQITPPPVMILKKKRSIGASPNPFSVHTATAVPSGKIASPVSRKEPPLTPVPLKRAEFAGDDVQVESTEEEQESGAMEFEDGDFDEPMEVEEVDLEP-------------MAAKAWDK----ESEPAEEVKQ--------------EADSGKGTVSYLGSFLPD---VSCWDIDQ-EGDSSFSVQEVQVDSSHLPLVKGADEEQV--FHFYWLDAYEDQYNQPGVVFLFGKVWIESAETHVSCCVMVKNIERTLYFLPREMKIDLNTGKETGTPISMKDVYEEFDEKIATKYKIMKFKSKPVEKN-----YAFEIPDVP--EKSEY-L---EVKY------SAEMPQ-----LPQDLKGE----------------------------TFSHVFGTNTSSLELFLMNRK-------IKGPC-----------------------------------------------------------------------------------------------------------------------------------------WLE-VKSPQLL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NQPVSWCKVEAMAL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KPDLVNVIKDVSPP---------------------------------------------------------------------------------------------------------------------------------------------------------------PLVVMA----------------------------------------------------------------------------------------------------------------------------FSMKTM----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
QNA------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KNHQNE---------------------------------------------------------------------------------------------------------------------------------------------------------IIAMAALVHHSFALDKAAPK---------------PPFQSHFCVVSKPKDCIFPYAFKEVIEKKNVK------------------------------VEVAATERTLLGFF-----------------LAKVH-KIDPD----------------------IIVGHNIYGFELEVLLQR------------------------------------------------------------------------------------------------------------------------INVCKAP--------HWSKIGRL----------------------------------------------------------KRSNMPKLGGRS-GFGE---RN--------------ATCGRMIC--D-VEISA-KELIRC-----K--SYHL---------SELVQQI-L----------------------KTE---------------------------------------------------------------------------------------------------RVVIPMEN--IQNMY-SE-----------SS-------QLLYLLEHTWKDAKFILQIMC--ELN----------------------------VLPLALQI-TNIAGNIMSRTLMGGRSERNEFLLLHA--------------------------FYENNYI----VP----------------DKQIFRK-----PQQKLGDEDEEIDGDTNKYKKGRKKAA------------------------------------------YAGGLVLDPK-VGFY-----------------------------------------------------------------DK-FILLLDFNSLYPSII-----QEFNICFTT---------------------------------------------------VQRVASEA-----QKVTEDGEQEQIPE-L---------------------------------------------------------------------------------------------------------------------------PDPS-------------------LEMG--ILPREIRKLVERRKQVK-----QLMK-------------------QQDLNPDL-ILQYDIRQKALKLTANSM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YGCLGF-SYSRFYAKPLAALVTYKGREILMHT-KEMVQK-------------------------------------------------------------------------------------MN--L-EVIYGD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TDSIMIN----------------------TNS-TNLEEV---FKLGNKVKSEVNK------LYKL------------LEIDIDGVF-KSLLL-------LK-KKKYA-------ALVVEPTSDGNYVTKQELKGLDIVRRDWCDLAKDTGNFVIGQILS---
DQSRDTIVENI--------------------QKRLIEIGENVL--NGSVPVSQFEI------NKALTKDPQDYPDKKSLPHVHV--ALWIN----SQG-GRK-V--KA---------------------------------------------------------------------------------------------------------GDTVSY---VIC----------------------------------QDGS-NLT----------------------ASQRAYAPEQLQKQDN--------------------------LTIDTQYYLA----------------QQIHP--VVARICEP----------------------------------------------------------------------------------------------I---DGIDAVLIATWLGLDPTQFRVHHYH------------------------------------KDEENDALLGGPAQ------------------LTDEEKYRDC-----------------------------------------------------------------------------------------------------ERFKCPCPTCGTENIYDNVF-------------------------------------------------------------------DGSGTDMEPSLYRCSNIDCKASPLTFTVQLS-----------------------------------------------------------------------------------------------------NKLIMDIRRFIKKYYDGWLICEEPTCRNRTRHLPLQFSRTGPLCPACMKATLQPEYSDKSLYTQLCFYRYIF-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DAECALEKLTTDHEKDKLKKQFFTPKVLQDYRKLKNTAEQFLSRSGYSEVNLSKLFAGCAVKS--------------------------------------------Mus_alpha--------------------------------------------MAPMHEEDCKLEASAVSDSGSFAASRARREKKSKKGRQEALERLKKAKAGEKYKYEVEDLTSVYEEVDEEQYSKLVQARQDDDWIVDDDGIGYVEDGREIFDDDLEDDALDTCGKGSDGKAHRKDRKDVKKPSVTKPNNIKAMFIASAGKKTTDKAVDLSKDDLLGDILQDLNTETAQITPPPVLIPKKKRSTGALLNPFSVHTPKAIPSGKPASPVLRNEPLLTPIPLKRAELAGELAQPECPEDEQELGVMEFEDGDFDESMDTEKVDEKP-------------VTAKTWDQ----ETEPVERVEH--------------EADPERGTTSYLENFLPD---VSCWDIDQ-DDES--IPQEVQVDSSNLPLVKGADDEQV--FQFYWLDAYEDPYNQPGVVFLFGKVWIESVKTHVSCCVMVKNIERTLYFLPREMKFDLNTGKETAIPVTMKDVYEEFDSKISAKYKIMKFKSKIVEKN-----YAFEIPDVP--EKSEY-L---EVRY------SAEVPQ-----LPQNLKGE----------------------------TFSHVFGTNTSSLELFLMNRK-------IKGPC-----------------------------------------------------------------------------------------------------------------------------------------WLE-VKNPQLL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NQPISWCKFEVMAL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KPDLVNVIKDVSPP---------------------------------------------------------------------------------------------------------------------------------------------------------------PLVVMS----------------------------------------------------------------------------------------------------------------------------FSMKTM----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QNV------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QNHQHE---------------------------------------------------------------------------------------------------------------------------------------------------------IIAMAALVHHSFALDKAPPE---------------PPFQTHFCVVSKPKDCIFPCDFKEVISKKNMK------------------------------VEIAATERTLIGFF-----------------LAKVH-KIDPD----------------------ILVGHNICSFELEVLLQR------------------------------------------------------------------------------------------------------------------------INECKVP--------YWSKIGRL----------------------------------------------------------RRSNMPKLGSRS-GFGE-----------------RNATCGRMIC--D-VEISA-KELIHC-----K--SYHL---------SELVQQI-L----------------------KTE---------------------------------------------------------------------------------------------------RIVIPTEN--IRNMYSES-----------S--------YLLYLLEHIWKDARFILQIMC--ELN----------------------------VLPLALQI-TNIAGNIMSRTLMGGRSERNEFLLLHA--------------------------FYENNYI----VP----------------DKQIFRK-----PQQKLGDEDEEIDGDTNKYKKGRKKAT------------------------------------------YAGGLVLDPK-VGFY-----------------------------------------------------------------DK-FILLLDFNSLYPSII-----QEFNICFTT---------------------------------------------------VQRVTSEV-----QKATEDEEQEQIP-EL------------------------------------------------------------------------------------------------------------
---------------PDPN-------------------LEMG--ILPREIRKLVERRKQVK-----QLMK-------------------QQDLNPDL-VLQYDIRQKALKLTANSM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YGCLGF-SYSRFYAKPLAALVTYKGREILMHT-KDMVQK-------------------------------------------------------------------------------------MN--L-EVIYGD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TDSIMIN----------------------TNS-TNLEEV---FKLGNKVKSEVNK------LYKL------------LEIDIDAVF-KSLLL-------LK-KKKYA-------ALVVEPTSDGNYITKQELKGLDIVRRDWCDLAKDTGNFVIGQILS---DQSRDTIVENI--------------------QKRLIEIGENVL--NGSVPVSQFEI------NKALTKDPQDYPDRKSLPHVHV--ALWIN----SQG-GRK-V--KA---------------------------------------------------------------------------------------------------------GDTVSY---VIC----------------------------------QDGS-NLT----------------------ATQRAYAPEQLQKLDN--------------------------LAIDTQYYLA----------------QQIHP--VVARICEP----------------------------------------------------------------------------------------------I---DGIDAVLIALWLGLDSTQ-FRV-HQYH----------------------------------KDEENDALLGGPAQ------------------LTDEEKYKDC-----------------------------------------------------------------------------------------------------EKFKCLCPSCGTENIYDNVF-EGSGLDME---------------------------------------------------------------PSLYRCSNVDC-KVSPLTF--MVQLS-----------------------------------------------------------------------------------------------------NKLIMDIRRCIKKYYDGWLICEEPTCCSRLRRLPLHF---SRNGPLC---PVCMKAVLRPEYSDKSLYTQLC------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FYRYIFDAD-CALEKL-TEHEKDKLKKQF----------FPLRVLQDYRKVKNIAEQFLSWSGYSEVNLSKLFA----------------------
NYAGKS----------------------Latimeria_alpha---------------------------------------------MAPVCTSEKDANGAGGDSGSSAANRSRREKKQKAGRTEALERLKKAKAGEKIKYEVEELTDVYDEVDEDQYSKIVRDRQDDDWIVDDDGIGYVEDGREIFDEDLDDDALESVVKG---------------GKQAANKDKKNVKKVAVSKPNSIKSMFMASAVKKTEKDVDLSKDDLLGDILQDLNTEVAPSPASVRKAAAVKAEMISVAPASLKVASSPVKAVASQLQLSSTSLVDSAGSGGAVKSREEEEIVPEEDPSAMEFEDGDFDEPM-------------EDDATPISTQRSELEPEV---T--------------AKKDGQLMVEEKPLKTPLALPVSCWDHRE-EDEADSRVLEVHVDSSRLPLVTGPDGDQV--FRFYWLDAFEDQYSQPGVVYLFGKVWIESAEMYVSCCVAVKNIERILYLLPRETRVNLSTGTDTGTPVILMDVYHEFNQQIAERYKIMKFRSKACKKN-----YAFEIPDVP--AQSDY-L---EIRY------SAELPQ-----LPQELKGE----------------------------TFSHVFGTNTSSLEHLLLSRK-------IKGPS-----------------------------------------------------------------------------------------------------------------------------------------WVD-IKMPQLS---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NQPVSWCKVEAIAA------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KPDFVSIVKDLPPP---------------------------------------------------------------------------------------------------------------------------------------------------------------PLVIMS----------------------------------------------------------------------------------------------------------------------------ISMKTV----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QNP--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
----------------------KTHQNE---------------------------------------------------------------------------------------------------------------------------------------------------------VVVLAALVHHKFPLQKAAPQ---------------PPFQTHFSVML-------MANGK---------------------------------------VEIAPTERTLLGFF-----------------LAKIH-KVDPD----------------------VIVGHNIYGFGLEVLLQR------------------------------------------------------------------------------------------------------------------------ILACKVP--------HWSKVGRL----------------------------------------------------------RRSVMPKLGGRS-GFAE---KN--------------ATCGRIIC--D-VEISA-KELIRC-----K--SYHL---------SELVHQI-L----------------------KTE---------------------------------------------------------------------------------------------------RVTIPPEN--IRNMY-SD-----------TP-------YLVSLLENTWVDTAFILQIMC--ELN----------------------------VLPLALQI-TNIAGNVMSRTLMGGRAERNEFLLLHA--------------------------FHEGDYI----VP----------------DKHIFKK-----PQLDLVDEDEEVDADHNKVKKGRKKAA------------------------------------------YAGGLVLEPK-VGFY-----------------------------------------------------------------DK-FILLLDFNSLYPSII-----QEFNICFTT----------------------------------------------------VRRVASS-----SSLKMDMEE--------------------------------------------------------------------------------------------------------------------------EIPEL---PEPD-------------------LEMG--VLPKEIRKLVERRRHVK-----QLMK-------------------QSDLNSDM-YLQYDIRQKALKLTANSM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YGCLGF-SYSRFYAKPLAALVTHKGREILMNT-KEMVQK-------------------------------------------------------------------------------------MN--L-EVIYGD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TDSIMIN----------------------TNS-TNLEEV---FKLGNKVKSEINK------LYKL------------LEIDIDGVF-KSLLL-------LK-KKKYA-------ALTVEQTANGQYVTKQELKGLDVVRRDWCDLAKETGNYVISQILS---DQSRDVIVDNI--------------------QKRLIEIGESVV--NGSISLKQFEI------HKALTKDPQDYPDKKSLPHVHV--ALWIN----SQV-GQR-V--
KA---------------------------------------------------------------------------------------------------------GDTVSY---IIC----------------------------------QDGS-SLS----------------------ASQRAYAPEQLQKQDN--------------------------LTIDTQYYLA----------------NQIHP--VVARICEP----------------------------------------------------------------------------------------------I---DGIDSVLIASWLGLDPSQFRASSHFH-----------------------------------RDEENDALLAGPAQ------------------LSDEEKYRDC-----------------------------------------------------------------------------------------------------ERFKFSCLKCGTENIYDSVF-----------------------------------------------------------------------EGSGHQIESSLKRCCKIECDAAPFHYA-------------------------------------------------------------------------------------------------AQMSNKLILDIRSHIKKYYSGWLICEEQTCQNRMRRLPLSFSRSGPICQACMKATLRPEYSEKALYTQLCYY------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RYIFDLEYAREKLVPEYGKGHRTNKLGEDMKEIYKKLKDVADKALCMSSYSEVNLSKLFQTLNKIK--------------------------------------------Drosophila_alphaMSESPSEPRAKRQRVDKNGRFAAMERLRQLKGTKNKCKVEDQVDDVYDVVDEREYAKRAQEKYGDDWIEEDGTGYAEDLRDFFEDEDEYSDGEEDRKDSKKKKGVAPNSKKRPRENEKPVTGKASIKNLFSNAVPKKMDVKTSVKDDDILADILGEIKEEPAATSEKAEKVIAPAKISVTSRKFDAAAAKEYMNSFLNNIKVQEQERKKAEASSDNEMLERILKPKAAVPNTKVAFFSSPTIKKEPMPEKTPAKKATEDPFSDNEMDFSCLDDDENQFDVEKTQQTEKVSQTKTAAEKTSQSKVAEKSAPKKETTGS---PKESESEDISRLLNNWESICQMDDDFEK---SVLTTEQDSTISSDQQLRFWYWEAYEDPVKMPGE--VFLFGRTA-DG------KSVCLR------VQN--------INRVLY----LLPRQFLLDPIS--------------------------KEPTKQKVTVADIYK-----------------EFDSEVANQLKLEFFRSRKVTKSFAHHAIGIEVPQSCDY-L---EVHY-DG---KKPLPN-----LSADKKYN----------------------------SIAHIFGATTNALERFLLDRK-------IKGPC-----------------------------------------------------------------------------------------------------------------------------------------WLQ-VTGFKVS-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PTPMSWCNTEVTLT------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EPKNVELVQDKGKP-----------------------------------------------------------------------------------------------------------------------------------------------------------APPPPLTLLS----------------------------------------------------------------------------------------------------------------------------LNVRTS----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MNP------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KTSRNE---------------------------------------------------------------------------------------------------------------------------------------------------------ICMISMLTHNRFHIDRPAPQ---------------PAFNRHMCALTRPAVVSWPLDLNFEMAKYKSTT-----------------------------VHKHDSERALLSWF-----------------LAQYQ-KIDAD----------------------LIVTFDSMDCQLNVITDQ------------------------------------------------------------------------------------------------------------------------IVALKI---------------------------------------------------------------------------PQWSRMGRLRLSQSFGK---RL------------LEHFVGRMVC--D-VKRSA-EECIRA-----R--SYDL---------QTLCKQV-L----------------------KLKESE------------------------------------------------------------------------------------------------RMEVNADD--LLEMYEKG-----------E--------SITKLISLTMQDNSYLLRLMC--ELN----------------------------IMPLALQI-TNICGNTMTRTLQGGRSERNEFLLLHA--------------------------FHEKNYI----VP----------------DKKPVSK-------RSGAGDTDATLSGADATMQTKKKAA------------------------------------------YAGGLVLEPM-RGLY-----------------------------------------------------------------EK-YVLLMDFNSLYPSII-----QEYNICFTT---------------------------------------------------VQQPVDAD----------------------------------------------------------------------------------------------------------------------------------------ELPTL---PDSK-------------------TEPG--ILPLQLKRLVESRKEVK-----KLMA-------------------APDLSPEL-
QMQYHIRQMALKLTANSM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YGCLGF-AHSRFFAQHLAALVTHKGREILTNT-QQLVQK-------------------------------------------------------------------------------------MN--Y-DVVYGD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TDSLMIN----------------------TNI-TDYDQV---YKIGHNIKQSVNK------LYKQ------------LELDIDGVF-GCLLL-------LK-KKKYA-------AIKLSKDSKGNLRREQEHKGLDIVRRDWSQLAVMVGKAVLDEVLS---EKPLEEKLDAV--------------------HAQLEKIKTQIA--EGVVPLPLFVI------TKQLTRTPQEYANSASLPHVQV--ALRMN----RER-NRR-Y--KK---------------------------------------------------------------------------------------------------------GDMVDY---VIC---------------------------------LDGTT-NAA-----------------------MQRAYHLDELKTSEDKK------------------------LQLDTNYYLG----------------HQIHP--VVTRMVEV----------------------------------------------------------------------------------------------L---EGTDASRIAECLGMDPTKFRQNAQR------------------------------------TQRENTEQSEGESL------------------LKTTLQLYRL----------------------------------------------------------------------------------------------------CEPFRFQCVTCK----------------------------------------------------------------------TEQLMASAYRPGPSNSHIAVLQQCAKSECQTAPIQYL-------------------------------------------------------------------------------------------------ASVRNQLQLSMRQYVQRFYKNWLVCDHPDCNFNTRTHSLRKKSHRPLCQKCRSGSLL----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RQYTERDLYNQLCYLRFMFDLGKQTLQQKPTLTPELEQAYQLLYETVDQQLQSSSYVIISLSKLFARSLAQMSLQPSVAQPQIEAIPSALADVV---------------Arabidopsis_alpha-----------------------MSGDNSTETGRRRSRGAEASSRKDTLERLKAIRQGGIRSASGGGYDIRLQKPIFDTVDDEE
YDALVSRRREEARGFVVEDGEGGDLGYLDEGEEEDWSKPSGPESTDESDDGGRFSGRLKKKKKGKEQTQQPQVKKVNPALKAAATITGEGRLSSMFTSSSFKKVKETDKAQYEGILDEIIAQVTPDESDRKKHTRRKLPGTVPVTIFKNKKLFSVASSMGMKESEPTPSTYEGDSVSMDNELMKEEDMKESEVIPSETMELLGSDIVKEDGSNKIRKTEVKSELGVKEVFTLN-ATIDMKEKDSALSATAGWKEAMGKVGTENGALLGSSSEGKTEFDLDADGSLRFFILDAYEEAFGASMGTIYLFGKVK-MGDTY---KSCCVV------VKN--------IQRCVY----AIPNDSIFPS----------------------------HELIMLEQEVKDSRLSPESFRGKLHEMASKLKNEIAQELLQLNVSNFSMAPVKRNYAFERPDVPAGEQYVL-----KINY------SFKDRP-----LPEDLKGE----------------------------SFSALLGSHTSALEHFILKRK-------IMGPC-----------------------------------------------------------------------------------------------------------------------------------------WLKISSFSTCS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PSEGVSWCKFEVTVQ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SPKDITILVSEEKVVHP------------------------------------------------------------------------------------------------------------------------------------------------------------PAVVTA----------------------------------------------------------------------------------------------------------------------------INLKTI----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VNE------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KQNISE---------------------------------------------------------------------------------------------------------------------------------------------------------IVSASVLCFHNAKIDVPMPAPERKR----------
SGILSHFTVVRNPEGTGYPIGWKKEVSDRNSKNGCNV-------------------------LSIENSERALLNRL-----------------FLELN-KLDSD----------------------ILVGHNISGFDLDVLLQR------------------------------------------------------------------------------------------------------------------------AQACKVQSS------MWSKIGRL----------------------------------------------------------KRSFMPKLKGNS-NYGS---GA--------TPGLMSCIAGRLLCDTDLCSRDL-LKEV----------SYSL---------TDLSKTQ-L----------------------NRD---------------------------------------------------------------------------------------------------RKEIAPND--IPKMFQSS-----------K--------TLVELIECGETDAWLSMELMF--HLS----------------------------VLPLTLQL-TNISGNLWGKTLQGARAQRIEYYLLHT--------------------------FHSKKFI----LP----------------DKISQRMKEIKSSKRRMDYAPEDRNVDELDADLTLENDPSKGSKTKKGPA-------------------------------YAGGLVLEPK-RGLY-----------------------------------------------------------------DK-YVLLLDFNSLYPSII-----QEYNICFTT------------------------------------------I----PR--SE----------------------------------------------------------------------------------------------------------------------------------------------DGVPR---LPSS-------------------QTPG--ILPKLMEHLVSIRKSVK-----LKMK-------------------KET--GLK-YWELDIRQQALKLTANSM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YGCLGF-SNSRFYAKPLAELITLQGRDILQRT-VDLVQN------------------------------------------------------------------------------------HLN--L-EVIYGD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TDSIMIH-----------------------SGLDDIEEV---KAIKSKVIQEVNK------KYRC------------LKIDCDGIY-KRMLL-------LR-KKKYA-------AVKLQFK-DGKPCEDIERKGVDMVRRDWSLLSKEIGDLCLSKILY---GGSCEDVVEAI--------------------HNELMKIKEEMR--NGQVALEKYVI------TKTLTKPPAAYPDSKSQPHVQV--ALRMR----QRGYKEG-F--NA---------------------------------------------------------------------------------------------------------KDTVPY---IIC----------------------------------YEQGNASS-----------------ASSAGIAERARHPDEVKSEGSR-------------------------WLVDIDYYLA----------------QQIHP--VVSRLCAE----------------------------------------------------------------------------------------------
I---QGTSPERLAECLGLDPSK-------------------------------------------YRSKSNDATSSDPSTSLLFA------------TSDEERYKSC-----------------------------------------------------------------------------------------------------EPLALTCPSCSTAFNCPSIISSVCASISK--------------------------------------------------------KPATPETEESDSTFWLKLHCPKCQQEDSTGIIS------------------------------------------------------------------------------------------------PAMIANQVKRQIDGFVSMYYKGIMVCEDESCKHTTRSPNFRLLGERERGTVCPNYPNCNGTLLRKYTEADLYKQLSY---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FCHILDTQCSLEKMDVGVRIQVEKAMTKIRPAVKSAAAITRSSRDRCAYGWMQLTDIVI--------------------------------------------------Leishmania_alpha----------------------------------------------------------------------------------------------------------MSGGNDGASWRLSRKPNAPNFDETQEDQWRSLREEVLQSDEDENIPESGDLTIPQLPSAKKAAKKLRKPPSGAKPTPKPKQQTLAQSMSDMDMERLLKRYRIDEDIDIAEDIDMSHLLQLHSDSDDGGDAQEATLTADEFLARLARAEAAPAASIAKEKRESGENVTVVALKDELFNVERDQSAKPPRPRPTPGAGGGAGYRNEETPKQAIELTATLAPQMDAAQFVSPAVPYKSGEMTEGL---F--------------YWFDAREQPHTLSVDPGS---LFLFGKMAVEKNGRTSYLSCCVR------VRN--------MYRSVF----VLPKAGS--------------------------------SQEDVVKEINDICR--------------------NQGIEQRRIKFVERY-----YAFEVPGVPH-EKTQW-A---KLRY------PGRYPP-----LNAKGPFR----------------------------HILIIMGASSSLLELFLIKRK-------LKGPS-----------------------------------------------------------------------------------------------------------------------------------------FLR-ISGLVAS---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ANRISHCALEFSVE------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SPKNLRA--------------------------------------------------------------------------------------------------------------------------------------------------------------EDTKLPVPPFTLAS---------------------------------------------------------------------------------------
-------------------------------------IQIHTQ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LDS------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KGACNE---------------------------------------------------------------------------------------------------------------------------------------------------------ILIASVAIYKDVNI---------------------ENTIRYIPDNILTGVRPASMSTPLPIDLESYCSAKGLPG-----------------------VRRFANERALLDWL-----------------AQQLG-KIDAD----------------------MMIGHNFLGFTLDILLRR------------------------------------------------------------------------------------------------------------------------YQELSI--------SSWSTIGRL----------------------------------------------------------DLKRLPRFQGTA-TNVN---QE------------KETCIGRLVV--D-SYSLS-REHYKT-----V--NYRL---------LSLADQMQL----------------------QGITKG------------------------------------------------------------------------------------------------SNNFEPGTSVLTPAMLSA-----------SR-------DIYDVLLQVCNCAVLSTAVVS--HLD----------------------------VIRLTKRL-TTIAGNLWSRTLFGARSERIEYLLLHT--------------------------FHDLKFI----TP----------------DRYVQNF---------------KRGRDDEEEEDGKRKAK------------------------------------------YQGGMVLDPK-CGLY-----------------------------------------------------------------SD-YILLLDFNSLYPSLI-----QEFNICFTT-----------------------------------------------VD--RESGSEID-----VPPPENLICASC-----------------------------------------------------------------------------------------------------------------------AAAGL---SAPC-------------------LHKC--VLPKVIKSLVDSRREVK-----RLMKI------------------EKD--ANN-LALLEIRQKALKLTANSM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YGCLGF-EYSRFHAQPLAELVTRQGRLALQST-
VDLIPQ-------------------------------------------------------------------------------------LNPSL-RVIYGD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TDSVMIQ---------------------TGIK-NDIKAV---RDLGLDLKAKINK------RYQS------------LEIDIDGVF-RAILL-------LK-KKKYA-------ALTVTDWQGEGKTYKKEVKGLDMVRRDWCPLSKCVCDSVLSRVLN---AEGSEDILDYV--------------------MNYMRDVSEKVR--AGRYTLDNFVI------SKSLTKEPEAYRG-NSFPHATV--ALRMK----QRK--EL-V--RV---------------------------------------------------------------------------------------------------------GDLIPY---VIC----------------------------------TGDR--------------------------LSDKAFHVEEVRQNSQ--------------------------LQIDSEWYLS----------------VQIYP--PVMRLCEH----------------------------------------------------------------------------------------------I---QGFSNAQLSEAMGIACHTGAKLEEEEA----------------------------------ETMNDFSHSSLFQ-------------------SRNLEECFPA------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ALSLQVACTHCRLMTPINPHT-----------------------------------------------------------------------------------------------------RVMEVLADQERQRDRFDLYVCVSCRKSLPVDYV-ANCFTQTCYGIIRQFYQCGSAAAVKAVRTQFTYYRALF------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DVPHAPGCPARVKDAHYYQARRCLGVDRRLYTLAEAADPAVQEVADPVDPLNAAAETIYKRIDHLFINLDSLFAGI------------------------------------------------Saccharomyces_alpha--------------------------------------------MSSKSEKLEKLRKLQAARNGTSIDDYEGDESDGDRIYDEIDEKEYRARKRQELLHDDFVVDDDGVGYVDRGVEEDWREVDNSSSDEDTGNLASKDSKRKKNIKREKDHQITDMLRTQHSKSTLLAHAKKSQKKSIPIDNFDDILGEFESGEVEKPNILLPSKLRENLNSSPTSEFKSSIKRVNGNDESSHDAGISKKVKIDPDSSTDKYLEIESSPLKLQSRKLRYANDVQDLLDDVENSPVVATKRQNVLQDTLLANPPSAQSLADEEDDEDSDEDIILKRRTMRSVTTTRRVNIDSRSNPST---S--------------PFVTAPGTPIGIKGLTPS---KSLQSNTDVAT------LAVNVK------KEDVVDPETDTFQMFWLDYCEVNNTLILFGKVKLKD-----------------------DNCVSAMVQINGLCRELFFLPREGKTPTDIHEEIIPLLMDKYGLDNIRAKPQKMKYSFELPDI
P--SESDY-L---KVLL------PYQTPKSSRDTIPSDLSSD----------------------------TFYHVFGGNSNIFESFVIQNR-------IMGPC-----------------------------------------------------------------------------------------------------------------------------------------WLD-IKGADFN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SIRNASHCAVEVSVD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KPQNITPTTTKTMP---------------------------------------------------------------------------------------------------------------------------------------------------------------NLRCLS----------------------------------------------------------------------------------------------------------------------------LSIQTL----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MNP------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KENKQE---------------------------------------------------------------------------------------------------------------------------------------------------------IVSITLSAYRNISLD--------------------SPIPENIKPDD---LCTLVRPPQSTSFPLGLAALAKQKLPGR--------------------VRLFNNEKAMLSCF-----------------CAMLK-VEDPD----------------------VIIGHRLQNVYLDVLAHR------------------------------------------------------------------------------------------------------------------------MHDLNIPTFSSI---------------------------------------------------------------------GRRLRRTWPEKF-GRGNSNMNH---------FFISDICSGRLIC--D-IANEM-GQSLTP-----KCQSWDL------------SEMYQV----------------------TCE---------------------------------------------------------------------------------------------------KEHKPLDIDYQNPQYQND-----------VN-------SMTMALQENITNCMISAEVSY--
RIQ----------------------------LLTLTKQL-TNLAGNAWAQTLGGTRAGRNEYILLHE--------------------------FSRNGFI----VP----------------DKEGNRS----------RAQKQRQNEENADAPVNSKKAK------------------------------------------YQGGLVFEPE-KGLH-----------------------------------------------------------------KN-YVLVMDFNSLYPSII-----QEFNICFTT---------------------------------------------------VDRNKEDI----------------------------------------------------------------------------------------------------------------------------------------DELPS---VPPSE------------------VDQG--VLPRLLANLVDRRREVK-----KVMKT------------------ETD--PHK-RVQCDIRQQALKLTANSM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YGCLGY-VNSRFYAKPLAMLVTNKGREILMNT-RQLAES-------------------------------------------------------------------------------------MN--L-LVVYGD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TDSVMID----------------------TGC-DNYADA---IKIGLGFKRLVNE------RYRL------------LEIDIDNVF-KKLLL-------HA-KKKYA-------ALTVNLDKNGNGTTVLEVKGLDMKRREFCPLSRDVSIHVLNTILS---DKDPEEALQEV--------------------YDYLEDIRIKVE--TNNIRIDKYKI------NMKLSKDPKAYPGGKNMPAVQV--ALRMR------KAGRV-V--KA---------------------------------------------------------------------------------------------------------GSVITF---VIT----------------------------------KQDEIDNA---------------ADTPALSVAERAHALNEVMIKSNN-------------------------LIPDPQYYLE----------------KQIFA--PVERLLER----------------------------------------------------------------------------------------------I---DSFNVVRLSEALGLDSKKYFRREGGNN----------------------------------NGEDINNLQPLETT------------------ITDVERFKDT-----------------------------------------------------------------------------------------------------VTLELSCPSCD-----------------------------------------------------------------------KRFPFGGIVSSNYYRVSYNGLQCKHCEQLFTPLQLT-----------------------------------------------------------------------------------------------------SQIEHSIRAHISLYYAGWLQCDDSTCGIVTRQV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SVFGKRCLNDGCTGVMRYKYSDKQLYNQLLYFDSLFDCEKNKKQELKPIYLPDDLDYPKEQLTESSIKALTEQNRELMETGRSVVQKYLNDCGRRYVDMTSIFDFMLNHomo_delta-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDGKRRPGPGPGVPPKRARGGLWDDDDAPRPSQFEEDLALMEEMEAEHRLQEQEEEELQSVLEGVADGQVPPSAIDPRWLRPTPPALDPQT---EPLIFQQLEIDHYVGPAQPVPGGPPPSHGSVPV---LRAFGVTD-EG------FSVCCH------IHG--------FAPYFY----TPAPPGFGP-----------------------------EHMGDLQRELNLAIN----------RDSRGGRELTGPAVLAVE--LCSRESM---FGYHGH-----GPSPF-L---RITV-AL---PRLVAP-----ARRLLEQG--------------------IRVAGLGTPSFAPYEANVDFEIRFMVDTD-------IVGCN-----------------------------------------------------------------------------------------------------------------------------------------WLE-LPAGKYA------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LRLKEKATQCQLEADVL-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------WSDVVSHPPEGPWQRIA-------------------------------------------------------------------------------------------------------------------------------------------------------------PLRVLS----------------------------------------------------------------------------------------------------------------------------FDIECA------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GRKGIFP----------------------------------------------------------------------------------------------------
--------------------------------------------------------------------------------------------------------------------------------------------EPERDP---------------------------------------------------------------------------------------------------------------------------------------------------------VIQICSLGLRWGEP---------------------EPFLRLALTLR---PCAPILGAK---------------------------------------VQSYEKEEDLLQAW-----------------STFIR-IMDPD----------------------VITGYNIQNFDLPYLISR------------------------------------------------------------------------------------------------------------------------AQTLKVQTFPFLGRVAGL---------------------------------------------------------------CSNIRDSSFQSK-QTGR---RD----------TKVVSMVGRVQM--D-MLQVL-LREYKL-----R--SYTL---------NAVSFHF-L----------------------GEQ---------------------------------------------------------------------------------------------------KEDVQHSI--ITDLQNGN-----------DQ-------TRRRLAVYCLKDAYLPLRLLE--RLM----------------------------VLVNAVEM-ARVTGVPLSYLLSRGQQVKVVSQLLRQ--------------------------AMHEGLL----MP----------------VVKSEGG------------------------------ED------------------------------------------YTGATVIEPL-KGYY-----------------------------------------------------------------DV-PIATLDFSSLYPSIM-----MAHNLCYTTLL----------------------------------------R----PG--TAQKLGLT-----EDQFIRT------------------------P---------------------------------------------------------------------------------------------------TGDEF---VKTS-------------------VRKG--LLPQILENLLSARKRAK-----AELAK------------------ETD--PLR-RQVLDGRQLALKVSANSV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YGFTGA-QVGKLPCLEISQSVTGFGRQMIEKT-KQLVES----------------------------------------------------------------------------KYTVENGYSTS--A-KVVYGD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TDSVMCR----------------------FGV-SSVAEA---MALGGEAADWVSGHF----PSP-------------IRLEFEKVY-FPYLL-------IS-KKRYA-------GLLFSSRP--DAHDRMDCKGLEAVRRDNCPLVANLVTASLRRLLI---DRDPEGA------------------------
VAHAQDVISDLL--CNRIDISQLVI------TKELTRAASDYA--GKQAHVEL--AERMR----KRDPGSA-P--SL---------------------------------------------------------------------------------------------------------GDRVPY---VII----------------------------------SAAK-GVA----------------------AYMKSEDPLFVLEHS---------------------------LPIDTQYYLE----------------QQLAK--PLLRIFEP----------------------------------------------------------------------------------------------I------LGEGRAEAVLL-----------------------------------------------RGDHTRCKTVLTGK------------------VGGLLAFAKR--------------------------------------------------------------------------------------------------------RNCCIGCR------------------------------------------------------------------------------------TVLSHQGAVCEFCQPR--ESELY-----------------------------------------------------------------------------------------------------QKEVSHLNALEERFSRLWTQCQRCQGSLHEDVI-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CTSRDCP----------IFYMRKKVRKDLEDQEQLLRRFGPPGPEAW-------------------------------------------------------Mus_delta-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDCKRRQGPGPGVPPKRARGHLWDEDEPSPSQFEANLALLEEIEAENRLQEAEEELQLPP--EGTVGGQFSTADIDPRWRRPTLRALDPST---EPLIFQQLEIDHYVGSAPPLPEGPLPSRNSVPI---LRAFGVTD-EG------FSVCCH------IQG--------FAPYFY----TPAPPGFGA-----------------------------EHLSELQQELNAAIS----------RDQRGGKELSGPAVLAIE--LCSRESM---FGYHGH-----GPSPF-L---RITL-AL---PRLMAP-----ARRLLEQG--------------------VRVPGLGTPSFAPYEANVDFEIRFMVDAD-------IVGCN-----------------------------------------------------------------------------------------------------------------------------------------WLE-LPAGKYV------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
RRAEKKATLCQLEVDVL-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------WSDVISHPPEGQWQRIA-------------------------------------------------------------------------------------------------------------------------------------------------------------PLRVLS----------------------------------------------------------------------------------------------------------------------------FDIECA------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GRKGIFP------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EPERDP---------------------------------------------------------------------------------------------------------------------------------------------------------VIQICSLGLRWGEP---------------------EPFLRLALTLR---PCAPILGAK---------------------------------------VQSYEREEDLLQAW-----------------ADFIL-AMDPD----------------------VITGYNIQNFDLPYLISR------------------------------------------------------------------------------------------------------------------------AQALKVDRFPFLGRVTGL---------------------------------------------------------------RSNIRDSSFQSR-QVGR---RD----------SKVISMVGRVQM--D-MLQVL-LREHKL-----R--SYTL---------NAVSFHF-L----------------------GEQ---------------------------------------------------------------------------------------------------KEDVQHSI--ITDLQNGN-----------EQ-------TRRRLAVYCLKDAFLPLRLLE--RLM----------------------------VLVNNVEM-ARVTGVPLGYLLTRGQQVKVVSQLLRQ--------------------------AMRQGLL----MP----------------VVKTEGS------------------------------ED------------------------------------------YTGATVIEPL-KGYY-----------------------------------------------------------------DV-PIATLDFSSLYPSIM-----MAHNLCYTTLLR--------------------------------------------PG--AAQKLGLK-----PDEFIKTP---------------------------------------------------------------------------------------------------------------------------TGDEF---VKSS-------------------VRKG--LLPQILENLLSARKRAK-----AELAQ------------------ETD--PLR-
RQVLDGRQLALKVSANSV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YGFTGA-QVGKLPCLEISQSVTGFGRQMIEKT-KQLVES----------------------------------------------------------------------------KYTVENGYDAN--A-KVVYGD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TDSVMCR----------------------FGV-SSVAEA---MSLGREAANWVSSHF----PSP-------------IRLEFEKVY-FPYLL-------IS-KKRYA-------GLLFSSRS--DAHDKMDCKGLEAVRRDNCPLVANLVTSSLRRILV---DRDPDGA------------------------VAHAKDVISDLL--CNRIDISQLVI------TKELTRAAADYA--GKQAHVEL--AERMR----KRDPGSA-P--SL---------------------------------------------------------------------------------------------------------GDRVPY---VII----------------------------------GAAK-GVA----------------------AYMKSEDPLFVLEHS---------------------------LPIDTQYYLE----------------QQLAK--PLLRIFEP----------------------------------------------------------------------------------------------I------LGEGRAESVLL-----------------------------------------------RGDHTRCKTVLTSK------------------VGGLLAFTKR--------------------------------------------------------------------------------------------------------RNCCIGCR------------------------------------------------------------------------------------SVIDHQGAVCKFCQPR--ESELY-----------------------------------------------------------------------------------------------------QKEVSHLNALEERFSRLWTQCQRCQGSLHEDVI-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CTSRDCP----------IFYMRKKVRKDLEDQERLLQRFGPPGPEAW-------------------------------------------------------Latimeria_delta--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
----------------------------------MDLKRRNAFGGALPSSQAKRPRGGDWDEDGPSQFEEELAYLDDIESEMMMQMEEEKGSSPQDVDSIRKSVLGVKNPRWLRPVLPNINPKT---DVLCFQQVELEHYVGPSSHISGMPGATHGPVPV---IRMFGITM-EG------NSVCCH------VHG--------FAPYFY----VPVQNGFSQ-----------------------------EHLSEFKRELNTVVI----------RDMRSNKDSISQAVLAVD--ICEKESI---YGYHGK-----RKIPF-L---KITM-AL---PRLIAP-----AKRLLEQG--------------------FRFGPFSVQAYQSYEANIDFEIRFMVDND-------VVGCN-----------------------------------------------------------------------------------------------------------------------------------------WIE-LPPGKYR------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IREEDKVSLCQIEVDIG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VNDFISHPAEGEWQKIA-------------------------------------------------------------------------------------------------------------------------------------------------------------PLRVLS----------------------------------------------------------------------------------------------------------------------------FDIECA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GRKG---IFP------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EPEKDP---------------------------------------------------------------------------------------------------------------------------------------------------------VIQIANMVLRQGEK---------------------DPFIRNVFTLN---SCAGIVGSK---------------------------------------VLSFEKESQLLQEW-----------------ADFIR-VVDPD----------------------IITGYNIQNFDLPYLLNR------------------------------------------------------------------------------------------------------------------------
ARTLKVAAFPHLSRIPAI---------------------------------------------------------------KSVIKDSSFQSK-QMGR---RE----------NKVINIEGRVQF--D-LLQVL-LRDYKL-----R--SYTL---------NAVSFHF-L----------------------QEQ---------------------------------------------------------------------------------------------------KEDVQHSI--ITDLQNGN-----------EQ-------TRRRLAVYCLKDAYLPLRLLE--KLM----------------------------CVINYMEM-ARVTGVPLSYLLSRGQQIKVVSQLLRQ--------------------------AMKQDLV----MP----------------VVKSEGG------------------------------ED------------------------------------------YTGATVIEPI-KGYY-----------------------------------------------------------------DV-PIATLDFSSLYPSIM-----MAHNLCYTT----------------------------------------------------LLQHGAV-----DKYSLSPEDFIKTP---------------------------------------------------------------------------------------------------------------------TGDHF---VKKS-------------------VRKG--LLPEILENLLAARKKAK-----NELKK------------------ETD--PFK-QKVLDGRQLALKVSANSV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YGFTGA-QVGKLPCLEIS----------------------------------------------------------------------------------------------------------------QVIYGD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TDSVMCK----------------------LGV-SSVEEA---MGIGREAAEWVSGHF----VFP-------------IKLEFEKVY-FPYLL-------IN-KKRYA-------GLYFSSSS--HTHDKMDCKGIETVRRDNCPLVANLINTCLQKILI---DRDPTGA------------------------VEHAKDVISDLL--CNRIDISQLVI------TKELTRTADEYA--GKQAHVEL--AQRMR----KRDAGSA-P--NL---------------------------------------------------------------------------------------------------------GDRVPY---VIV----------------------------------KAAK-GVA----------------------AYMKSEDPIYVLENN---------------------------IPIDTQYYLE----------------QQLAK--PLLRIFEP----------------------------------------------------------------------------------------------I------LGETKAESILL-----------------------------------------------KGEHTRCKTVLTSK------------------VGGLTAFTKK----------------------------------------------------------------------------------------------
----------RSTCIGCK------------------------------------------------------------------------------------ALLKDDGAVCDYCSSR--QSELY-----------------------------------------------------------------------------------------------------QKEISHLSSLEEKFARLWTQCQRCQGSLHEDVL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CTSRDCP----------IFYMRKKVQKDLGDQERLVSRFGPP---TW-------------------------------------------------------Drosophila_delta----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDGKRKFNGTSNGHAKKPRNPDDDEEMGFEAELAAFENSEDMDQTLLMGDGPENQTTSERWSRPPPPELDPSKHNLEFQQLDVEN------------------YLG----QPLPGM---P--------------GAQIGP---------VPV---VRMFGVTM-EG------NSVCCH------VHG--------FCPYFY----IEAPSQF------EE-----------------------HHCEKLQKALDQKVI----------ADIRNNKDNVQEAVLMVE--LVEKLN--I-HGYNGD-----KKQRY-I---KISV-TL---PRFVAA-----ASRLLKKE--------------------VIMSEIDFQDCRAFENNIDFDIRFMVDTD-------VVGCN-----------------------------------------------------------------------------------------------------------------------------------------WIE-LPMGHWR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IRNSHSKPLPESRCQIEVDVA------------------------FDRFIS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------HEPEGE----WSKVA-------------------------------------------------------------------------------------------------------------------------------------------------------------PFRILS----------------------------------------------------------------------------------------------------------------------------FDIECA----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GRKG---IFP------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EAKIDP---------------------------------------------------------------------------------------------------------------------------------------------------------VIQIANMVIRQGER---------------------EPFIRNVFTLN---ECAPIIGSQ---------------------------------------VLCHDKETQMLDKW-----------------SAFVR-EVDPD----------------------ILTGYNINNFDFPYLLNR------------------------------------------------------------------------------------------------------------------------AAHLKVRNFEYLGRIKNI---------------------------------------------------------------RSVIKEQMLQSK-QMGR---RE----------NQYVNFEGRVPF--D-LLFVL-LRDYKL-----R--SYTL---------NAVSYHF-L----------------------QEQ---------------------------------------------------------------------------------------------------KEDVHHSI--ITDLQNGD-----------EQ-------TRRRSAMYCLKDAYLPLRLLE--KLM----------------------------AIVNYMEM-ARVTGVPLESLLTRGQQIKVLSQLLRK--------------------------AKTKGFI----MP----------------SYTSQGS-----------------------------DEQ------------------------------------------YEGATVIEPK-RGYY-----------------------------------------------------------------AD-PISTLDFASLYPSIM-----MAHNLCYTT---------------------------------------------------LVLGGTREKLRQQENLQDDQVERTP-----------------------------------------------------------------------------------------------------------------------ANNYF---VKSE-------------------VRRG--LLPEILESLLAARKRAK-----NDLKV------------------ETD--PFK-RKVLDGRQLALKISANSV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YGFTGA-QVGKLPCLEISGSVTAYGRTMIEMT-KNEVES----------------------------------------------------------------------------HYTQANGYENN--A-VVIYGD---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TDSVMVN----------------------FGV-KTLERS---MELGREAAELVSSKF----VHP-------------IKLEFEKVY-YPYLL-------IN-KKRYA-------GLYFTRP---DTYDKMDCKGIETVRRDNSPLVANLMNSCLQKLLI---ERDPDGA------------------------VAYVKQVIADLL--CNRIDISHLVI------TKELAKT--DYA--AKQAHVEL--AAKMK----KRDPGTA-P--KL---------------------------------------------------------------------------------------------------------GDRVPY---VIC----------------------------------AAAK-NTP----------------------AYQKAEDPLYVLENS---------------------------VPIDATYYLE----------------QQLSK--PLLRIFEP------------------------------------------------------------------------------------------------------------ILGDNAESILL----------------------------------------KGEHTRTRTVVTSK------------------VGGLAGFMTK--------------------------------------------------------------------------------------------------------KTSCLGCK---------------------------------------------------------------------------------SLMPKGYEQACLCPHCEPR--MSELY-----------------------------------------------------------------------------------------------------QKEVGAKRELEETFSRLWTECQRCQESLHEEVI-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CSNRDCP----------IFYMRQKVRMDLDNQEKRVLRFGLAEW----------------------------------------------------------Arabidopsis_delta-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MNRSGISKKRPPPSNTPPPAGKHRATGDSTPSPAIGTLDDEFMMEEDVFLDETLLYGDEDEESLILRDIEERESRSSAWARPPLSPAYLSNSQSIIFQQLEI----------------DSIIA----ESHKEL---L--------------PGSSGQ---------API---IRMFGVTR-EG------NSVCCF------VHG--------FEPYFY----IACPPGM------GP-----------------------DDISNFHQSLEGRMR------------ESNKNAKVPKFVKRIE--MVQKRSIMY-YQQQ-------KSQTF-L---KITV-AL---PTMVAS-----CRGILDRG--------------------LQIDGLGMKSFQTYESNILFVLRFMVDCD-------IVGGN-----------------------------------------------------------------------------------------------------------------------------------------WIE-VPTGKYK-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KNARTLSYCQLEFHCL------------------------YSDLISHAA-------------------------------------------------------------------------------------------------------------------------------------------------------------------EGEYSKMA-----------------------------------------------------------------------------------------------------------------------------------------------------------------------PFRVLS----------------------------------------------------------------------------------------------------------------------------FDIECA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GRKG---HFP------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EAKHDP---------------------------------------------------------------------------------------------------------------------------------------------------------VIQIANLVTLQGED---------------------HPFVRNVMTLK---SCAPIVGVD---------------------------------------VMSFETEREVLLAWRVLFLPLHYYICITSSSSDLIR-DVDPD----------------------IIIGYNICKFDLPYLIER------------------------------------------------------------------------------------------------------------------------AATLGIEEFPLLGRVKNS---------------------------------------------------------------RVRVRDSTFSSR-QQGI---RE----------SKETTIEGRFQF--D-LIQAI-HRDHKL-----S--SYSL---------NSVSAHF-L----------------------SEQ---------------------------------------------------------------------------------------------------KEDVHHSI--ITDLQNGN-----------AE-------TRRRLAVYCLKDAYLPQRLLD--KLM----------------------------FIYNYVEM-ARVTGVPISFLLARGQSIKVLSQLLRK--------------------------GKQKNLV----LP----------------NAKQSGS----------------------------EQGT------------------------------------------YEGATVLEAR-TGFY-----------------------------------------------------------------EK-PIATLDFASLYPSIM-----MAYNLCYCTLV----------------------------------------T----PE--DVRKLNLP-----PEHVTKT------------------------P---------------------------------------------------------------------------------------------------
SGETF---VKQT-------------------LQKG--ILPEILEELLTARKRAK-----ADLKE------------------AKD--PLE-KAVLDGRQLALKISANSV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YGFTGA-TVGQLPCLEISSSVTSYGRQMIEQT-KKLVED----------------------------------------------------------------------------KFTTLGGYQYN--A-EVIYGD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TDSVMVQ----------------------FGV-SDVEAA---MTLGREAAEHISGTF----IKP-------------IKLEFEKVY-FPYLL-------IN-KKRYA-------GLLWTNP---QQFDKMDTKGIETVRRDNCLLVKNLVTESLNKILI---DRDVPGA------------------------AENVKKTISDLL--MNRIDLSLLVI------TKGLTKTGDDYE--VKSAHGEL--AERMR----KRDAATA-P--NV---------------------------------------------------------------------------------------------------------GDRVPY---VII----------------------------------KAAK-GAK----------------------AYERSEDPIYVLQNN---------------------------IPIDPNYYLE----------------NQISK--PLLRIFEP----------------------------------------------------------------------------------------------V--------LKNASKELL-----------------------------------------------HGSHTRSISITTPS------------------NSGIMKFAKK--------------------------------------------------------------------------------------------------------QLSCVGCK-------------------------------------------------------------------------------------VPISNGTLCASCKGR--EAELY-----------------------------------------------------------------------------------------------------CKNVSQVAELEEVFGRLWTQCQECQGSLHQDVL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CTSRDCP----------IFYRRMKAQKDMAVARQQLDRWSF-------------------------------------------------------------Leishmania_delta
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSSSALSLWKSIVRLPLPASYLHKDV----------------RFQLL----DCCQT-------------------KGNPHETVSRVRHSEVPV---VRLYGVTA-EG------FSVLVH------CYN--------YEPYLW----IEAPPNWLP-----------------------------VHSQEFMRELNNQLS---------------NQTRLQDTVVRVE--VHQRRSLMYFKGG--------QLVPH-L---KIVV-QL---PQHIPK-----LRSLLSDR-----------------GVSCPGAWDGTRVFQTFESNVIFPLRFLVDND-------IGGSN-----------------------------------------------------------------------------------------------------------------------------------------WLT-LTYGKFF-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ASPIKTSTCQIEVACS----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HEDVQNHEPLGDYLSIA--------------------------------------------------------------------------------------------------------------------------------------------------------------PFRILS----------------------------------------------------------------------------------------------------------------------------IDIECQ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GRKGLFP------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EPEHDP---------------------------------------------------------------------------------------------------------------------------------------------------------VIQIANHCVEYGHES--------------------EPLTKTIFTLK---SCAPIAGAQ---------------------------------------VLSYETEAEMLLAW-----------------ATFMK-ALDPD----------------------ILTGYNICNFDFPYLLNR------------------------------------------------------------------------------------------------------------------------
ATALKASDAFHYWGRQVHE--------------------------------------------------------------RTVARDKKFQSK-QMGN---RE----------YTELTLEGRIIM--D-AMVVI-QRDYKL-----R--SYSL---------NSVSQNF-L----------------------GEQ---------------------------------------------------------------------------------------------------KEDVHHSI--ISDLQHGD-----------EE-------TRRRLAVYCLKDAFLPVKLLD--RLM----------------------------CIVNNVEM-ARVTGVPVGWLLERGQQIKVFSMLLRK--------------------------AQKKKLV----VP----------------TVEYTGG----------------------------SDRG------------------------------------------YEGATVIDPI-KGFY-----------------------------------------------------------------NC-PVATLDFASLYPSII-----IAHNLCYST-----------------------------------------------LV--RPADARLY-----PEDALDRS-----------------------P---------------------------------------------------------------------------------------------------TSDVF---VKKE-------------------VFPG--ILPEVLQDLLAARKHAR-----AMMKDV-----------------PMN--SLE-YKVLNGRQLALKVSANSV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YGFTGA-QVGKLPCLEISASVTAYGRQMIDRT-KNLVEE-----------------------------------------------------------------------------------LYPG--A-RVLYGD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TDSVMVK-----------CVT----DEKSSDK-ERLQAA---MDFGIEAAEKVSS-NF---LKP-------------IKLEFEKVY-FPYLL-------MN-KKRYA-------GLLWTST---DRFDKLDAKGIETVRRDNCPLVARMVSGVLNRILI---HRSVESA------------------------VEFVKGTISDLL--LNRLDISNLVI------TKAFSKAEDEYA--GAQAHIAL--VERMR----QRDPASA-P--TI---------------------------------------------------------------------------------------------------------GDRVAY---VII----------------------------------KAAK-GAK----------------------AYERSEDPIYVLDNN---------------------------IPIDTQYYLE----------------HQLAP--PIMRVFEG---------------------------------------------------------------------------------------------------------VLDDPSVLIKG-------------------------------------------DHTRHIAISAPSKN------------------AGGLMRFVKV--------------------------------------------------------------------------------------------------------QLQCISCR-------------------------------------------------------------------------------------
AVIKAGALCDNCQDK--APEVY-----------------------------------------------------------------------------------------------------GKIVAKRNHYEAIYSQVWTQCQQCQGSLNQEVI-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CSSRDCP----------VFYMRKKVQKDLHEQQVLLDRFGVVDDW---------------------------------------------------------Saccharomyces_delta-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSEKRSLPMVDVKIDDEDTPQLEKKIKRQSIDHGVGSEPVSTIEIIPSDSFRKYNSQGFKAKDTDLMGTQLESTFEQELSQMEHDMADQEEHDLSSFERKKL----------------PTDFDPSLYDISFQQ---I--------------DAEQSVLNGIKDENTSTV---VRFFGVTS-EG------HSVLCN------VTG--------FKNYLY----VPAPNSSDANDQ--------------------------EQINKFVHYLNETFD---------------------HAIDSIE--VVSKQSI---WGYSGD-----TKLPF-W---KIYV-TY---PHMVNK-----LRTAFERG-------------------HLSFNSWFSNGTTTYD-NIAYTLRLMVDCG-------IVGMS-----------------------------------------------------------------------------------------------------------------------------------------WIT-LPKGKYS-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MIEPNNRVSSCQLEVSIN-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YRNLIAHPAEGDWSHTA-------------------------------------------------------------------------------------------------------------------------------------------------------------PLRIMS----------------------------------------------------------------------------------------------------------------------------FDIECA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GRIGVFP------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EPEYDP---------------------------------------------------------------------------------------------------------------------------------------------------------VIQIANVVSIAGAK---------------------KPFIRNVFTLN---TCSPITGSM---------------------------------------IFSHATEEEMLSNW-----------------RNFII-KVDPD----------------------VIIGYNTTNFDIPYLLNR------------------------------------------------------------------------------------------------------------------------AKALKVNDFPYFGRLKTV---------------------------------------------------------------KQEIKESVFSSK-AYGT---RE----------TKNVNIDGRLQL--D-LLQFI-QREYKL-----R--SYTL---------NAVSAHF-L----------------------GEQ---------------------------------------------------------------------------------------------------KEDVHYSI--ISDLQNGDSE------------------TRRRLAVYCLKDAYLPLRLME--KLM----------------------------ALVNYTEM-ARVTGVPFSYLLARGQQIKVVSQLFRK--------------------------CLEIDTV----IP----------------NMQSQAS-----------------------------DDQ------------------------------------------YEGATVIEPI-RGYY-----------------------------------------------------------------DV-PIATLDFNSLYPSIM-----MAHNLCYTT----------------------------------------------------LCNKATV-----ERLNLKIDEDYVITP--------------------------------------------------------------------------------------------------------------------NGDYF---VTTK-------------------RRRG--ILPIILDELISARKRAK-----KDLRD------------------EKD--PFK-RDVLNGRQLALKISANSV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YGFTGA-TVGKLPCLAISSSVTAYGRTMILKT-KTAVQE----------------------------------------------------------------------------KYCIKNGYKHD--A-VVVYGD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
TDSVMVK----------------------FGT-TDLKEA---MDLGTEAAKYVSTLF----KHP-------------INLEFEKAY-FPYLL-------IN-KKRYA-------GLFWTNP---DKFDKLDQKGLASVRRDSCSLVSIVMNKVLKKILI---ERNVDGA------------------------LAFVRETINDIL--HNRVDISKLII------SKTLAP---NYT--NPQPHAVL--AERMK----RRE-GVG-P--NV---------------------------------------------------------------------------------------------------------GDRVDY---VII----------------------------------GGND-KLY------------------------NRAEDPLFVLENN---------------------------IQVDSRYYLT----------------NQLQN--PIISIVAP----------------------------------------------------------------------------------------------I--------IGDKQANGM-----------------------------------------------FVVKSIKINTGSQ-------------------KGGLMSFIKK--------------------------------------------------------------------------------------------------------VEACKSCK-----------------------------------------------------------------------------------GPLRKGEGPLCSNCLAR--SGELY-----------------------------------------------------------------------------------------------------IKALYDVRDLEEKYSRLWTQCQRCAGNLHSEVL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CSNKNCD----------IFYMRVKVKKELQEKVEQLSKW---------------------------------------------------------------Homo_epsilon------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSLRSGGRRRADPGA--DGEASRDDGATSSVSALKRLERSQWTDKMDLRFGFERLKEPG--------------EKTGWLI----NMHPTE---I--------------LDEDKRL--------GSA---VDYYFIQD-DG------SRFKVA------LP---------YKPYFY----IATRKGC---------------------------------EREVSSFLSKKFQ-----------GKIAKVETVPKEDLDLPNHLVGLKRNYIRLSFHTVEDLVKVRKEISP---AVKKNRE---QDHASDAYTALLSSVLQRG----------GVITDEEETSKKIADQLDNIVDMREYDVPYHIRLSIDLK-------IHVAH-----------------------------------------------------------------------------------------------------------------------------------------WYN-VRYRGNA------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FPVEITRRDDLVERP-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DPVVLA----------------------------------------------------------------------------------------------------------------------------FDIETT---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KLPL---KFP------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DAETDQ---------------------------------------------------------------------------------------------------------------------------------------------------------IMMISYMIDGQGYL-----------------------ITNREIVSE---DIEDFEFTPKPEYEGPFC------------------------------VFNEPDEAHLIQRW-----------------FEHVQ-ETKPT----------------------IMVTYNGDFFDWPFVEAR------------------------------------------------------------------------------------------------------------------------AAVHG----------------------------------------------------------------------------LSMQQEIGFQKD-SQGE---YK---------------APQCIHM--D-CLRWV-KRDSYL-----PVGSHNL---------KAAAKAK-L----------------------GYD---------------------------------------------------------------------------------------------------PVELDPED--MCRMATE---------------------QPQTLATYSVSDAVATYYLYM--KY-----------------------------VHPFIFAL-CTIIPMEPDEVLRKGSGTLCEALLMVQ--------------------------AFHANII----FP----------------NKQEQEF------------------NKLTDDGHVLDSET------------------------------------------YVGGHVEALE-SGVFRSDIPCRFRMNPAAFDFLLQRVEKTLRHALEEEEKVPVEQVTNFEEVCDEIKSKLASLKDVPSRIECPLIYHLDVGAMYPNII-----LTNRLQPSAMVDE--------------------------ATCAA-------CDFNKPG--ANCQRKMAWQWRGEFMPASRSEYHRIQHQLESEKFP--
PLFPEGP-----------------------------------------------------------------------------------ARAFHELSREEQAKYEKRRLA---DYCRKAYKKIHITKV-EERLTTICQRENSFYVDTVRAFRDRRYEFK-----GLHKVWKKKLSAAVEVGDAAEV-KRC--KNM-EVLYDSLQLAHKCILNSF--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YGYVMR-KGARWYSMEMAGIVCFTGANIITQA-RELIEQ-------------------------------------------------------------------------------------IG----RPLELD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TDGIWCVLPNSFPENFVFKTTNVKKPKVTISY-PGAMLN---IMVKEGFTNDQYQEL----AEPSSLTYVTRSENS-IFFEVDGPY-LAMILPASKEEGKKLKKRYA-------VFNEDGS-------LAELKGFEVKRRGELQLIKIFQSSVFEAFLK---GSTLEEVYGSV--------------------AKVADYWLDVLY--SKAANMPDSELFELISENRSMSRKLEDYGE-QKSTSIST--AKRLA----EFL-GDQ-MVKDA---------------------------------------------------------------------------------------------------------GLSCRY---IIS----------------------------------RKPE-GSP----------------------VTERAIPLAIFQAEPTVRKHFLRKWLKSSSLQDFDIR-----AILDWDYYIERLGSAIQKIITIPAALQQVKN--PVPRVKHPDWLHKKLLEKNDVYKQKKISELFTLEGRRQVTMAEASEDSPRPSAPDMEDFGLVKLPHPAA--PVTVKRKRVLW--ESQEESQDLTPTVPWQEILGQPPALGTSQE-EWLVWLRFHKKKWQLQAR----------------------------------QRLARRKRQRLESAEGVLRPGA-IRDGP----ATGLGSFLRRTARSILDLPWQIVQISETSQAGLFRLWALVGSDLHCIRLSIPRVFYVNQR-VAKAEEGASYRKVNRVLPRSNMVYN--------LYEYSVPEDMYQEHINEINAELSAPDIEGVYETQVPLLFRALVHLGCVCVVNKQLVR---HLSGWEAETFALEHLEMRSLAQFSYLEPGS--IRHIYLYHHA--QAHKALFGIFIPSQRRASVFVLDTVRSNQMP---SLGALYSAEHGLLLEKV---GPELLPPPKHTFEVRAETDLKTICRAIQRFLLAYKEERRGPTLIAVQSSWELKRLASEIPVLEEFPLVPICVADKIN-YGVLDWQRHGARRMIRHYLNLDTCLSQAFEMSRYFHIPIGNLPEDISTFGSDLFFARHLQR
HNHLLWLSPTA--RPDLGGKEADDNCLVMEFDDQATVEINSSGCYSTVCVELDLQNLAVNTILQSHHVNDMEGADSMGISFDVIQQASLEDMITGGQAASAPASYDETALCSNTFRILKSMVVGWVKEITQYHNIYADNQVMHFYRWLRSPSSLLHDPALHRTLHNMMKKLFLQLIAEFKRLGSSVIYANFNRIILCTKKRRVEDAIAYVEYITSSIHSKETFHSLTISFSRCWEFLLWMDPSNYGGIKGKVS-------SRIHCGLQDSQKAGGAEDEQENEDDEEERDGEEEEEAEESNVEDL-LENNWNILQFLPQAASCQNYFLMIVSAYIVAVYHCMKDGLRRSAPGSTPVRRRGA-SQLSQEAEGAVGALPGMITFSQDYVANELTQSFFTITQKIQKKVTGSRNSTELSEMFPVLPGSHLLLNNPALEFIKYVCKVLSLDTNITNQVNKLNRDLLRLVDVGEFSEEAQFRDPCRSYVLPEVICRSCNFCRDLDLCKDSSFS-EDGAVLPQWLCSNCQAP--YDSSAIEMTLVEVLQKKLMAFTLQDLVCLKCRGVKETSMPVYCSCAGDFALTIHTQVFMEQIGIFRNIAQHYGMSYLLETLEWLLQKNPQLGHMus_epsilon--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MVLRNSGRRHPEPGADGEGSRDDGPSSSVSALKRLERSQWTDKMDLRFGFERLKEPG--------------ERTGWLI----NMHPTE---I--------------LDEDKRL--------VSA---VDYYFIQD-DG------SRFKVA------LP---------YMPYFY----IAARKGC---------------------------------DREVSSFLSKKFQ-----------GKIAKLENVPKEDLDLPNHLVGLKRSYIKLSFHTVEDLVKVRKEISP---AVKKNRE---QDHASDEYTTMLSSILQGG----------SVITDEDETSKKIADQLDNIVDMREYDVPYHIRLSIDLR-------IHVAH-----------------------------------------------------------------------------------------------------------------------------------------WYN-VRFRGNA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FPVEITRRDDLVERP-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DPVVLA----------------------------------------------------------------------------------------------------------------------------
FDIETT---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KLPL---KFP------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DAETDQ---------------------------------------------------------------------------------------------------------------------------------------------------------IMMISYMIDGQGYL-----------------------ITNREIVSE---DIEDFEFTPKPEYEGPFC------------------------------VFNEPDEVHLIQRW-----------------FEHIQ-ETKPT----------------------IMVTYNGDFFDWPFVEAR------------------------------------------------------------------------------------------------------------------------AAIHG----------------------------------------------------------------------------LSMYQEIGFQKD-SQGE---YK---------------APQCIHM--D-CLRWV-KRDSYL-----PVGSHNL---------KAAAKAK-L----------------------GYD---------------------------------------------------------------------------------------------------PVELDPED--MCRMATE---------------------QPQTLATYSVSDAVATYYLYM--KY-----------------------------VHPFIFAL-CTIIPMEPDEVLRKGSGTLCEALLMVQ--------------------------AFHANII----FP----------------NKQEQEF------------------NKLTDDGHMLDAET------------------------------------------YVGGHVEALE-SGVFRSDIPCRFRMNPAAFDFLLQRVEKTMRHAIEEEEKVPVEQATNFQEVCEQIKTKLTSLKDVPNRIECPLIYHLDVGAMYPNII-----LTNRLQPSAIVDE--------------------------ATCAA-------CDFNKPG--ASCQRKMAWQWRGEFMPASRSEYHRIQHQLESEKFP--PLFPEGP-----------------------------------------------------------------------------------ARAFHELSREEQAKYEKRRLA---DYCRKAYKKIHVTKV-EERLTTICQRENSFYVDTVRAFRDRRYEFK-----GLHKVWKKKLSAAVEVGDASEV-KRC--KNM-EILYDSLQLAHKCILNSF--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
------------------------------------------YGYVMR-KGARWYSMEMAGIVCFTGANIITQA-RELIEQ-------------------------------------------------------------------------------------IG----RPLELD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TDGIWCVLPNSFPENFVIKTTNAKKPKLTISY-PGAMLN---IMVKEGFTNHQYQEL----TEPSSLTYVTHSENS-IFFEVDGPY-LAMILPASKEEGKKLKKRYA-------VFNEDGS-------LAELKGFEVKRRGELQLIKIFQSSVFEAFLK---GSTLEEVYGSV--------------------AKVADYWLDVLY--SKAANMPDSELFELISENRSMSRKLEDYGE-QKSTSIST--AKRLA----EFL-GDQ-MVKDA---------------------------------------------------------------------------------------------------------GLSCRY---IIS----------------------------------RKPE-GSP----------------------VTERAIPLAIFQAEPTVRKHFLRKWLKSSSLQDFDIR-----TILDWDYYIERLGSAIQKIITIPAALQQVKN--PVPRVKHPDWLHKKLLEKNDIYKQKKISELFVLEGKRQIVMAQASENSLSLCTPDMEDIGLTKPHHSTV--PVATKRKRV-W--ETQKESQDIALTVPWQEVLGQPPSLGTTQE-EWLVWLQFHKKKWQLQAQ----------------------------------QRLALRKKQRLESAEDMPRLGP-IREGP----STGLGSFLRRTARSIMDLPWQIIQISETRQAGLFRLWAIIGNDLHCIKLSIPRVFYVNQR-VAKAEDGPAYRKVNRALPRSNIVYN--------LYEYSVPEDMYQEHINEINTELSVPDIEGVYETQVPLLFRALVQLGCVCVVNKQLTR---HLSGWEAETFALEHLEMRSLAQFSYLEPGS--IRHIYLYHHT--QGHKALFGVFIPSQRRASVFVLDTVRSNQMP---GLSALYSSEHSLLLDKV---DPKLLPPPKHTFEVRAETNLKTICRAIQRFLLAYKEERRGPTLIAVQSSWELCRLTSEIPVLEEFPLVPIRVADKIS-YAVLDWQRHGARRMIRHYLNLDLCLSQAFEMSRYFHIPVGNLPEDISTFGSDLFFARHLQHHNHLLWLSPTS--RPDLGGKEADDNRLVMEFDDRATVEINSSGCYSTVCVELDIQNLAVNTILQSHHVNDMEGAGSMGISFDVIQQASLEDMVTGNQAASALANYDETALCSSTFRILKSMVVGWVKEITQYHNIYADNQVMHFYRWLQSPCSLLHDPALHRTLHNMMKKLFLQLIAEFKRLGSSVVYANFNRIILCTKKRRIEDALAYVEYITNSIHSKEIFHSLTISFSRCWEFLLWMDPSNYGGIKGKVP-------SSIHCG-QVKEQDSQAREETDEEEEDKEKD-EEEEGMGESEVEDL-LENNWNILQFLPQAASCQSYFLMIVSAYIVAVYQSMKEELRHSAPGSTPVKRKGA-SQFSQESEGATGSLPGMITFSQDYVANELTQSFFTITQKIQKKVTGSRNTTEPSEMFPVLPGSHLLLNNPALEFIKYVCKVLSLDTNITNQVNKLNRDLLRLVDVGEFSEEAQFRDPCHSYVLPE
VICHSCNFCRDLDLCKDSSFS-QDGAILPQWLCSNCQAP--YDSSAIESALVEALQRKLMAFTLQDLVCLKCRGMKETHMPVYCSCAGDFTLTIRTEVFMEQIRIFQNIAKYYSMSYLQETIEWLLQTSPVSNCLatimeria_epsilon--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MVLQNSGRLKPESKGRWDTENQQDDGANLSALKRLERSQWTDEMDGRFGFERLKEPG--------------EKTGWLI----NMHPTE---I--------------LDEDKRM--------ISA---VDYYFLQE-DG------SRFKVA------LP---------YKPYFY----VATRKGC---------------------------------EREVSSFLSKKFQ-----------GKISKLETVPKEDLDLPNHLVGLKRNYIKLAFNTVDDLVKVRKDISP---AVRRNKE---RDNSRDAYTTMLSSALAGT----------SVTTEEGGTSKKMADQMDNIIDIREYDVPYHVRLSIDLK-------IHVAH-----------------------------------------------------------------------------------------------------------------------------------------WYN-IRNRGSS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YPPEIARRDDLVERP-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DPVVLA----------------------------------------------------------------------------------------------------------------------------FDIETT---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KLPL---KFP------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
DPESDQ---------------------------------------------------------------------------------------------------------------------------------------------------------IMMMSYMIDGQGYL-----------------------ITNREIVSE---DIEDFEFTPKPEYEGPFC------------------------------VFNEPDEAKLIQRW-----------------FEHVQ-ETKPN----------------------IFVTYNGDFFDWPFVEAR------------------------------------------------------------------------------------------------------------------------AAVHG----------------------------------------------------------------------------LNMYREIGFQKD-SQGE---YK---------------STQSIHM--D-CLRWV-KRDSYL-----PVGSHNL---------KAAAKAK-L----------------------GYD---------------------------------------------------------------------------------------------------PVELDPEE--MCRMATE---------------------EPQTLATYSVSDAVATYYMYM--KY-----------------------------VHPFIFAL-CTIIPMEPDEVLRKGSGTLCEALLMVQ--------------------------AFHANII----FP----------------NKQQQVF------------------NKLTDDGHVLDSET------------------------------------------YVGGHVEALE-SGVFRSDIPCRFKMNPAAFDFLLQRIEKTLHHAIEEEENIPLEQVTNLQEVCDEIKKKLTCLKEVPNRIECPLIYHLDVGAMYPNII-----LTNRLQPSAMVDE--------------------------ATCAA-------CDFNKPG--TTCQRRMAWQWRGEFMPATRSEYHRIQQQLESEKFP--PIFPNGP-----------------------------------------------------------------------------------PQAFHALSREEQAKYEKKRLA---DYCRKAYKKIHITRI-EERVTTICQRENSFYVDTVRAFRDRRYEFK-----GLHKVWKKKLSAAMESGDASEV-KRC--KNM-EILYDSLQLAHKCILNSF--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YGYVMR----------------------------------------------------------------------------------------------------------------------KG----RPLELD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TDGIWCVLPNSFPENFVIKSTNAKKPKVTISY-PGAMLN---IMVKEGFTNDQYQEL----VDPTSLTYISRSENS-IFFEVDGPY-LAMILPASKEEGKKLKKRYA-------VFNEDGS-------
LAELKGFEVKRRGELQLIKIFQSSVFEAFLK---GTTLEEVYASV--------------------AKVADYWLDVLY--SKAANMPDSELFELISENRSMSRKLEDYGE-QKSTSIST--AKRLA----EFL-GDQ-MVKDA---------------------------------------------------------------------------------------------------------GLSCRY---VIS----------------------------------KKPE-GSP----------------------VTERAIPLAIFQAEPSVRKHYLRKWLKSPSLQEFEIR-----SILDWDYYIERLGSAIQKIITIPAALQQVKN--PVPRVRHPDWLHKKLLEKNDVYKQKKINELFSSEGKRQITSNQPVESSQQSEIADMEDLGAPKRLQPSI--PIASKRKRVVAGGQSQEESQDLELTQSWREILGPPPPIGSTKD-ERLVWLRYHKKKWELQAR----------------------------------QRKERRKKRRLEDGEAVTGGGGIIRDTL----TTGLGSFLRRTARTILDMPWQLVQIAETNQPGLFKLWAVIGSDLHSIKLNIPRVFHVNQR-IPKLEESTAYRKVNRILPRSNVVYN--------LYEYSVPEDMYQEHINEINADLSAPDIEGVYETQIPLLFRALVQLGCVCMVNKQLIR---HLAGREAETFELEHLEMRSLAQFAYLEPGS--IRHIYLYHNS--QGNKALFGLFIPSQRKVSVFVVDTVRSNQMP---NLNNMYSVERTAMLEKV---DEELLPPDKHSFEIRAETDLKTVYRAIQRLLLNYKDERRGPTLIAIQSNWDLKRLSNGMPVFEEFPLVPVHIIDEIS-YNVLDWQRHGARRMIKHYLNLDSCLTQAFEMARYYHIPVGNLPEDISTFGSDLFFSRHLRRHNHLLWLSPNS--RPDLGGKEMDDNRLVMEFDEKVSVEINNPGCYSTVCVELDIQSLAVNTILQSHHINDMEGASSVGISFDVIQQASLEDMVTGNQ-TNTLASYDETALCSNTFRILKSMVVGWVKEITQYHNVYADNQVMHFYRWLRSPSSLLYDPALHRMLHNMMKKLFLQLVAEFKRLGSSIVYGNFNRIILCTKKRRIEDAIGYVEYITNSIHTREIFHSLTISFSRCWEFILWMDPANYGGIKGKLP-------SSIMYG--ETEKKKGEEGSEDEEEEAVDPD---EDSAGEDDVEEL-LENNWNIMQFLPQEASCQSYFLMIVSAYIVAVYHSMKEEMRRNAPGSTPVKRRGASSQVSQESEGDAGALPGMITFSQDYVSNELTQNFFTITQKIQKKVTGTRRATEPSEMFPVLPGSYLPLNNPALEFIKYVCRALSLDMNITNQVNKLKRDLLRLVDVGEFSEEAQFKDPCQSYILPEVICRHCNFCRDLDLCKDPSMA-QDGTVLPSWLCTNCQAE--YDSGSIEMALVEAVQKKLMAYTLQDLVCTKCKGIKEANMPIYCSCAGDFDLTISKKGFSEQMKVFRKIAHHYGMPFLLETIEWLVQMNPPICTDrosophila_epsilon----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
MSDSSKGKVLQNTGKFVSENRTEGDDFFNEAGYRQSRENDKIDSKYGFDRVKDSQ--------------ERTGYLI----NMHSNE---V--------------LDEDRRL--------IAA---LDLFFIQM-DG------SRFKCT------VA---------YQPYLL----IRPEDNM---------------------------------HLEVARFLGRKYS-----------GQISGLEHITKEDLDLPNHLSGLQQQYIKLSFLNQTAMTKVRRELMS---AVKRNQE---RQKSNTYYMQMLATSLAQS----------SAGSEDATLGKRQQDYMDCIVDIREHDVPYHVRVSIDLR-------IFCGQ-----------------------------------------------------------------------------------------------------------------------------------------WYN-IRCRSGV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ELPTITCRPDILDR----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PEPVVLA----------------------------------------------------------------------------------------------------------------------------FDIETT---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KLPL---KFP------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DAQTDQ---------------------------------------------------------------------------------------------------------------------------------------------------------VMMISYMIDGQGYL-----------------------ITNREIISS---NVDDFEYTPKPEFEGNFI------------------------------VFNEENEMQLLQRF-----------------FDHIM-EVRPH----------------------IIVTYNGDFFDWPFVETR------------------------------------------------------------------------------------------------------------------------AAVYD----------------------------------------------------------------------------LDMKQEIGFSKL-
RDGN---YL---------------SRPAIHM--D-CLCWV-KRDSYL-----PVGSQGL---------KAVAKAK-L----------------------RYD---------------------------------------------------------------------------------------------------PVELDPED--MCRMAVE---------------------QPQVLANYSVSDAVATYYLYM--KY-----------------------------VHPFIFAL-NTIIPMEPDEILRKGSGTLCETLLMVE--------------------------AYHAQIV----YP----------------NKHQSEL------------------NKLSNEGHVLDSET------------------------------------------YVGGHVEALE-SGVFRADIPCRFRLDPAMVKQLQEQVDAVLRHAIEVEEGIPLEKVLNLDEVRQEIVQGLQGLHDIPNRLEQPVIYHLDVGAMYPNII-----LTNRLQPSAMVSD--------------------------LDCAA-------CDFNKPG--VRCKRSMDWLWRGEMLPASRNEFQRIQQQLETEKFP--PLFPGGP-----------------------------------------------------------------------------------QRAFHELSKEDQAAYEKKRLT---DYCRKAYKKTKLTKL-ETRTSTICQKENSFYVDTVRAFRDRRYEYK-----GLTKVAKASVNAAVASGDAAEI-KAA--KGR-EVLYDSLQLAHKCILNSF--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YGYVMR-RGARWHSMPMAGIVCLTGSNIITKA-REIIER-------------------------------------------------------------------------------------VG----RPLELD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TDGIWCILPGSFPQEFTIHTSHEKKKKINISY-PNAVLN---TMVKDHFTNDQYH-ELRKDKENNLPKYDIRDENS-IFFEVDGPY-LAMVLPAAKEEGKKLKKRYA-------VFNFDGT-------LAELKGFEVKRRGELQLIKNFQSSVFEAFLA---GSTLEECYASV--------------------AKVADYWLDVLY--SRGSNLPDSELFELISENKSMSKKLEEYGA-QKSTSIST--AKRLA----EFL-GEQ-MVKDA---------------------------------------------------------------------------------------------------------GLACKY---IIS----------------------------------KKPE-GAP----------------------VTERAIPLAIFQSEPSVRRHHLRRWLKDNTMGDADIR-----DVLDWNYYIERLGGTIQKIITIPAALQGLAN--PVPRVQHPDWLHKKMLEKNDVLKQRRINEMFTSRPKPKPLATEEDK------
LADMEDLAGKDGGEGAAGCPIVTKRKRIQL--EEHDDEEAQPQATTWRQALGAPPPIGETRK-TIVEWVRFQKKKWKWQQD----------------------------------QRQRNRQASKRTRGEDPPVVRA---TGS----TATLGGFLRRAQRTLLDQPWQIVQLVPVDDLGHFTVWALIGEELHKIKLTVPRIFYVNQRSAAPPEEGQLWRKVNRVLPRSRPVFN--------LYRYSVPEQLFRDNSLGMLADLATPDIEGIYETQMTLEFRALMDMGCICGVQREEARRLAQLATKDLETFSIEQLEQRPQTQVKYLASANNRLRKIYLYQHNTPTAKKEIWSLILMPSKKAFVFALDTVRANQMP---NMRQLYTAERLALLKNLTAEEQDKIPVEDYTFEVLIEVDVKQIYRHIQRALTTYKQEHQGPTILCLQTALSARKLSLAMPILLEFPQAEIHISDDASLLSGLDWQRQGSRAVIRHFLNLNNVLDLMLDQCRYFHVPIGNMPPDTVLFGADLFFARLLQRHNFVLWWSAST--RPDLGGREADDSRLLAEFEESISVVQNKAGFYPDVCVELALDSLAVSALLQSTRIQEMEGASS-AITFDVMPQVSLEEMI-GTVPAATLPSYDETALCSAAFRVMRSMVNGWLREVSINRNIFSDFQIVHFYRWVRSSNALLYDPALRRSLNNLMRKMFLRIIAEFKRLGATIIYADFNRIILSSGKKTVSDALGYVDYIVQSLRNKEMFHSIQLSFEQCWNFMLWMDQANFSGIRGKLPKGIDETVSSIVSTTMIRDSERNQDDDEDEEEDSENRDPVESNEAEQDQEDELSLELNWTIGEHLPDENECREKFESLLTLFM---------------------------QSLAEKK-------------TTEQAIKDISHCAFDFILKLHKNYGKGKPS-------------------PGLELIRTLIKALSVDKTLAEQINELRRNMLRLVGIGEFSDLAEWEDPCDSHIINEVICKACNHCRDLDLCKDKHRAMKDG--VPVWLCAQCYVA--YDNEEIEMRMLDALQRKMMSYVLQDLRCSRCSEIKRENLAEFCTCAGNFVPLISGKDIQTLLGTFNKVAANHKMQLLQQTVHQALTTPR----Arabidopsis_epsilon---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSGDNRRRDRKDTRWSKKPKVVNTAEDELESKLGFGLFSEGETR----------------LGWLL----TFSSSS---W--------------EDRDTGKV-------YSC---VDLYFVTQ-DG------FSFKTK-------YK--------FRPYFY----AATKDKM---------------------------------ELELEAYLRRRYE-----------RQVADIEIVEKEDLDLKNHLSGLQKKYLKISFDTVQQLMEVKRDL-L---HIVE-RNQAKFDALEA-----YESILAGK------------------REQRPQDCLDSIVDLREYDVPYHVRFAIDND-------VRSGQ-----------------------------------------------------------------------------------------------------------------------------------------WYN-
VSISSTD---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VILEKRTDLLQRAE------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VRVCA----------------------------------------------------------------------------------------------------------------------------FDIETT---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KLPL---KFP------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DAEYDQ---------------------------------------------------------------------------------------------------------------------------------------------------------IMMISYMVDGQGFL-----------------------IINRECVGE---DVEDLEYTPKPEFEGYFK------------------------------VTNVKNEVELLQRW-----------------FYHMQ-ELKPG----------------------IYVTYNGDFFDWPFIERR------------------------------------------------------------------------------------------------------------------------ASHHG----------------------------------------------------------------------------IKMNEELGFRCDQNQGE---CR---------------AKFACHL--D-CFAWV-KRDSYL-----PQGSHGL---------KAVTKAK-L----------------------GYD---------------------------------------------------------------------------------------------------PLEVNPED--MVRFAME---------------------KPQTMASYSVSDAVATYYLYM--TY-----------------------------VNPFIFSL-ATIIPMVPDEVLRKGSGTLCEMLLMVE--------------------------AYKANVV----CP----------------NKNQADP------------------EKFYQN-QLLESET------------------------------------------YIGGHVECLE-SGVFRSDIPTSFKLDSSAYQQLIDNLGRDLEYAITVEGKMRMDSISNYDEVKDEIKEKLEKLR
DDPIREEGPLIYHLDVAAMYPNII-----LTNRLQPPSIVTD--------------------------EICTA-------CDFNRPG--KTCLRKLEWVWRGVTFMGKKSDYYHLKKQIESEFVD--AGANIMS-----------------------------------------------------------------------------------SKSFLDLPKVDQQSKLKERLK---KYCQKAYKRVLDKPITEVREAGICMRENPFYVDTVRSFRDRRYEYK-----TLNKVWKGKLSEAKASGNSIKI-QEA--QDM-VVVYDSLQLAHKCILNSF--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YGYVMR-KGARWYSMEMAGVVTYTGAKIIQNA-RLLIER-------------------------------------------------------------------------------------IG----KPLELD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TDGIWCCLPGSFPENFTFKTIDMK--KLTISY-PCVMLN---VDVAKNNTNDQYQ-TL---VDPVRKTYKSHSECS-IEFEVDGPY-KAMIIPASKEEGILIKKRYA-------VFNHDGT-------LAELKGFEIKRRGELKLIKVFQAELFDKFLH---GSTLEECYSAV--------------------AAVADRWLDLLD--NQGKDIADSELLDYISESSTMSKSLADYGE-QKSCAVTT--AKRLA----EFL-GVT-MVKDK---------------------------------------------------------------------------------------------------------GLRCQY---IVA----------------------------------CEPK-GTP----------------------VSERAVPVAIFTTNPEVMKFHLRKWCKTSS--DVGIR-----LIIDWSYYKQRLSSAIQKVITIPAAMQKVAN--PVPRVLHPDWLHKKVREKDDKFRQRKLVDMFSSANKDVVLDTDLPVTKDN--VEDIEDFCKENRPSVKGPKPIARSY-------EVNKKQSECEQQESWDTEFHDISFQNIDKSVNYQGWLELK-KRKWKVTL----------------------------------EKKKKRRL--GDLRSSNQVDTHEINQKVGQG-RGGVGSYFRRPEEALTSSHWQIIQLVPSPQSGQFFAWVVVEGLMLKIPLSIPRVFYINSK--VPIDEYFQGKCVNK---ILPHGRPCYS-----LTEVKIQEDQFKKESKKRAALLADPGVEGIYETKVPLEFSAICQIGCVCKIDNKAKHRNTQ-DGWE-----VGELHMKTTTECHYLKRS---IPLVYLYNST--STGRAIYVLYCHVSKLMSAVVVDPFN-GNELLPSALERQFRDSCLEL-------SLDSLSWDGIRFQVHYVDHPEAAKKIIQRAISEYREENCGPTVAVIECP-
DFTFMKEGIKALDDFPCVRIPFNDDDNSYQPVSWQRPAAKIAMFRCAAAFQWLDRRITQSRYAHVPLGNFGLDWLTFTIDIFLSRALRDQQQVLWVSDNG-VPDLGGINNE-EAFFADEVQQTSLVF---PGAYRKVSVELKIHNLAVNALLKSNLVNEMEGGGFMGFEQDVNPR---------GINSNDNTSFDETTGCAQAFRVLKQLIHSCLTDVRKSKNIYADSILQRLSWWLCSPSSKLHDPALHLMLHKVMQKVFALLLTDLRRLGAIIIYADFSKVIIDTVKFDLSAAKAYCESLLSTVRNSDIFEWILLEPVHYWHSLLFMDQYNYAGIRAD--------------------------------------DEISLDEVTIEPKWSVARHLPE----YIERDFIIIIAKFIFDPWKFAIEN------------KKGSSESLEAQ--------------MIEYLREQIGSTFINMLVKKVDDIMSHM------KEINVSDASRV--SGQAPKGDYSLEFIQVISAVLALDQNVQQDVLVMRKSLLKYIKVKECAAEAEFLDPGPSFILPNVACSNCDAYRDLDICRDPALLTEKE-----WSCADTQCGKIYDREQMESSLLEMVRQRERMYHMQDVVCIRCNQVKAAHLTEQCECSGSFRCKESGSEFSKRMEIFMDIAKRQKFRLLEEYISWIIYGPSY---Leishmania_epsilon---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSS---F--------------GP-------------QII---SEIIAVEK-ED------LDLVNH------LSG---------KKRVY--------------------------------------------LKVVFRNVQDLTT----------------VRGRLEKTVKLNASLGSENP---------------LRSQF-SGSLGDAM-AK---PFAEDP-----LYSAAGSS------------------------RWMDWVQDIREYDVKYHMRVAIDMK-------VYCGL-----------------------------------------------------------------------------------------------------------------------------------------WYD-VTVTEGG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ARVQRCDDSRYAP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AMPRVIA----------------------------------------------------------------------------------------------------------------------------FDIETT----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KAPL---RFP------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QPEVDE---------------------------------------------------------------------------------------------------------------------------------------------------------VYMISYMLDGRGYLI----------------------INREIVTE----DIAPFEYTPKPEYEGFFD------------------------------TFNEENEAATLRRF-----------------FDEMR-KYKPN----------------------VYVTYNGDYFDFPFIHAR------------------------------------------------------------------------------------------------------------------------ALYHG----------------------------------------------------------------------------MNMRNEIGFTQM-ADGA---FL---------------NKQIPHL--D-CFYWV-KRDSYL-----PQGSQGL---------KAVTKYK-L----------------------GYE---------------------------------------------------------------------------------------------------PIEVDPED--MLPLAQS---------------------QPQRMASYSVSDAVSTWYLYQ--KY-----------------------------VHPFIFSL-ATIIPMPPDDVLRKGSGGLCESLLMVQ--------------------------AEANNVV----FP----------------NKKEIER-------------------ERFYEGHLIDTET------------------------------------------YIGGRVEALR-SGVYRSDIPMTFDMNPDTYQSLIDDVDEALRFTLEVENGVKVEEVTNLEEVRAAILAKLTNLRDRPHQQEKPFIYHLDVGAMYPNII-----LTNRLQPYAIARP--------------------------DVCAG-------CCFNSPNNEAQCKRVMSWKWRAELFTAGRYEFQRVKAQLENESFA--AGVIEQANLAAVQKKAYGNRKGNVLEGTSYERKDDWKKSQSSRNGGGGAGYRQESRQQQREAADALLQREFGADRNGEGGSSDSDGDADGPKAYHKLNENTQFNMLKRRLS---EYSRKAYGKIHETRE-VMRSNVVCQRENSFYVDTVRLFRDRRYEYK-----AALKTWKKRLDAAK---DSDER-KVC--QSR-CVQMESLQLAHKCILNSF--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YGYVMR-KGSRWSSMEMAGIVTYLGATLIQMA-RSLVQQ-------------------------------------------------------------------------------------IG----
VTLELD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TDGIWCCLPNTFPENFTLATTNPSKPKISISY-PCVVLN---KMVHDRYSNHQYQDLVSTGVYKTRSECS-------IYFEVDGPY-LAMLLPASREEGKSIKKRYA-------VFSPDGS-------LAELKGFELKRRGELMLVKDFQSQVFRRFLD---GRTLADAYASA--------------------AVVADAALDMLE--SKGEGYDTEEILEKITESSNMTRRLSEYPESQKSLAITT--ARRIA----EFL-GPQ-MVKDK---------------------------------------------------------------------------------------------------------GLACHF---IIS----------------------------------RMPA-GRP----------------------VTERAIPVTIFRADPAVRTHFLRKWTADTTVPSELNLK----TLLDWDYYTARFSACVQKIVSIPAALQSLPN--PVPRVVHPDWLEKRIRHRNSRYRQVSLLGMLSKVQGKNEALAGVSAAAAAAAVRVDEDEDGVVLEQGGGAGAVEGELQDLEDMAGGAGSSTVRHAPKTQKARAACAGERRCAAGTDAETDWDEDDTDCEGESE----------------------------------DDMERLQREADAELDALAHDVKQRYFAPRSANALDADFFADR----GAKRWLAQRKDTWLQRARLRRELALENGRSEVALGGENSDAVTLGQATAPDVAGMNSHFIDLKSRALATVWNVLEVRENEESPGTVQVLAALEHSLYSFRVQVCRTVLVDADPALRLQAFDATEVSGRVLPRRAAAGRLYQVNVPPGEEGERCLNALHVMEGVRRIYEEHRTRVDTFVEQLGCCVSVDSARHLRNARRRPPSQRELFGIDEMNMHTCTNYLSCGAADRAVFVFHAVTEQRGLIAAVYPQTNTAFVVFIQPAEAAKPVISWSSICAESAKRLHTSTPEPIRVTSAVAEDQRAAWRQVHQHLSAALENAKAPLLAVLQSCQPTSTLLQQRALPVGLPYLRVLGAAEDERLLSDPFRWTRLLARRLFERFFASLLWVEERLALSRVSGIPLCNIAQDSCVHVLDVLYSRALHRRHHVLWCSSDPLITFDTVEERPREVCMAGGYTSWCVEFGLSRLDVVALLFSQAIEEGDDPNARVLCDRGVSTHFNILRDLVADLLGQAMENILADTLLNNVARWLRDPASSCYEPRLVELLSSLAHRALTGILLRLAKLGGRAVKVDGSSVTVLTSKYSLQEAVSFARFLTASLQDQPMLLLLSLQPLRYWCPYVVLDPCDYAGLFITED------------------------------------------------------------AIKLKQGEEPTRADLHVAHQLTMASRLPSRARNTFVERVVETLYQLNASTHHVYCDTVGDHTVTLATRHDHLTRRLLQDSQKLFEGVLQTDIMDEVQRVMDTRDLYTEEEHAAHERGELTLWSSGAVALEYAKCVCRVLELIPCNGAVGKVRNNCMRLCGISPFSAQSQFQADPFLAHRLQSVTCSFCNSHISIDLLVRRKSVTSPFTCTACAAPIAAASMEGTLVRHVSQLLRVYNQEDFVCTKCREMTTTYVAETCCGALVGKAAPVEGELRALHHLAKIQGFAWLAESVEAALLCT---------Saccharomyces_epsilon----------------------------------------------------------------------------------------------------------------
------------------------------------------------------------------------------------------------------------------------------------MMFGKKKNNGGSSTARYSAGNKYNTLSNNYALSAQQLLNASKIDDIDSMMGFERYVPPQYNGRFDAKDIDQIP--------------GRVGWLT----NMHATL---V--------------SQETLSSGSNGGGNSNDG---ERVTTNQGISG-----VDFYFLD------EEGGSFKSTVVYDPYFF----IACNDES--------------------------------RVNDVEELVKKYLE---------------------SCLKSLQ--IIRKEDLTM-DNHLLG-----LQKTL-I---KLSF-VN---SNQLFE-----ARKLLRPILQDNANNNVQRNIYNVAANGSEKVDAKHLIEDIREYDVPYHVRVSIDKD-------IRVGK-----------------------------------------------------------------------------------------------------------------------------------------WYK-VTQQGFI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EDTRKIAFA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DPVVMA----------------------------------------------------------------------------------------------------------------------------FDIETT---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KPPL---KFP------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DSAVDQ---------------------------------------------------------------------------------------------------------------------------------------------------------IMMISYMIDGEGFLI----------------------TNREIISE----DIEDFEYTPKPEYPGFFT------------------------------IFNENDEVALLQRF-----------------FEHIR-DVRPT----------------------VISTFNGDFFDWPFIHNR-------------------------------------------------------------------------------
-----------------------------------------SKIHG----------------------------------------------------------------------------LDMFDEIGFAPD-AEGE---YK---------------SSYCSHM--D-CFRWV-KRDSYL-----PQGSQGL---------KAVTQSK-L----------------------GYN---------------------------------------------------------------------------------------------------PIELDPEL--MTPYAFE---------------------KPQHLSEYSVSDAVATYYLYM--KY-----------------------------VHPFIFSL-CTIIPLNPDETLRKGTGTLCEMLLMVQ--------------------------AYQHNIL----LP----------------NKHTDPI-------------------ERFYDGHLLESET------------------------------------------YVGGHVESLE-AGVFRSDLKNEFKIDPSAIDELLQELPEALKFSVEVENKSSVDKVTNFEEIKNQITQKLLELKENNIRNELPLIYHVDVASMYPNIM-----TTNRLQPDSIKAE--------------------------RDCAS-------CDFNRPG--KTCARKLKWAWRGEFFPSKMDEYNMIKRALQNETFPNKNKFSKKK-----------------------------------------------------------------------------------VLTFDELSYADQVIHIKKRLT---EYSRKVYHRVKVSEI-VEREAIVCQRENPFYVDTVKSFRDRRYEFK-----GLAKTWKGNLSK-IDPSDKHAR-DEA--KKM-IVLYDSLQLAHKVILNSF--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YGYVMR-KGSRWYSMEMAGITCLTGATIIQMA-RALVER-------------------------------------------------------------------------------------VG----RPLELD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TDGIWCILPKSFPETYFFTLENGK--KLYLSY-PCSMLN---YRVHQKFTNHQYQ-EL---KDPLNYIYETHSENT-IFFEVDGPY-KAMILPSSKEEGKGIKKRYA-------VFNEDGS-------LAELKGFELKRRGELQLIKNFQSDIFKVFLE---GDTLEGCYSAV--------------------ASVCNRWLDVLD--SHGLMLEDEDLVSLICENRSMSKTLKEYEG-QKSTSITT--ARRLG----DFL-GED-MVKDK---------------------------------------------------------------------------------------------------------GLQCKY---IIS----------------------------------SKPF-NAP----------------------VTERAIPVAIFSADIPIKRSFLRRWTLDPSLEDLDIR-----
TIIDWGYYRERLGSAIQKIITIPAALQGVSN--PVPRVEHPDWLKRKIATKEDKFKQTSLTKFFS-KTKNVPTMGK---------IKDIEDLFEPTVEEDNAKIKIARTTKKKAV--SKRKRNQLTNEEDP----LVLPSEIPSMDE-DYVGWLNYQ-KIKWKIQA----------------------------------RDRKRRDQLFGNTNSSRE--------------RSALGSMIRKQAESYANSTWEVLQYKDSGEPGVLEVFVTINGKVQNITFHIPKTIYMKFKSQTMPLQKIKNCLIEKSSASLPNNPKTSNPAGGQLFKITLPESVFLEEKENCTSIFNDENVLGVFEGTITPHQRAIMDLGASVTFRSKAMG---ALGKGIQQGFEMKDLSMAENE--RYLSGFS--MDIGYLLHFPT-SIGYEFFSLFKSWGDTITILVLKPSNQAQEINASSLGQIYKQMFEKKKGKIETYSYLVDIKEDINFEFVYFTDISKLYRRLSQETTKLKEERGLQFLLLLQSPF-ITKLLGTIRLLNQMPIVKLSLNEVL--LPQLNWQPTLLKKLVNHVLSSGSWISHLIKLSQYSNIPICNLRLDSMDYIIDVLYARKLKKENIVLWWNEKAPLPDHGGIQNDFDLNTSWIMNDSEFPKINNSGVYDNVVLDVGVDNLTVNTILTSALINDAEGSDLVNNNMGIDDK---------DAVINSPSEFVHDAFSNDALNVLRGMLKEWWDEALK-ENSTADLLVNSLASWVQNPNAKLFDGLLRYHVHNLTKKALLQLVNEFSALGSTIVYADRNQILIKTNKYSPENCYAYSQYMMKAVRTNPMFSYLDLNIKRYWDLLIWMDKFNFSGLACI------------------------------------EIEEKENQDYTAVSQWQLKKFLSPIYQPEFEDWMMIILDSMLKTKQSYLKLNSGTQRPTQIVNVKKQDKED------------------SVENSLNGFSHLFSKPLMKRVKKLFKNQQEFILDPQYEADYVIPVLPGSHLNVKNPLLELVKSLCHVMLLSKSTILEIRTLRKELLKIFELREFAKVAEFKDPSLSLVVPDFLCEYCFFISDIDFCKAAPES--------IFSC--VRCHKAFNQVLLQEHLIQKLRSDIESYLIQDLRCSRCHKVKRDYMSAHCPCAGAWEGTLPRESIVQKLNVFKQVAKYYGFDILLSCIADLTI-------Homo_zeta------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAFSIDRALN-----------VALGNPSSTAQHVFKVS--LVSGMP--F-YGYHE------KERHF-M---KIYL-YN---PTMVKR-----ICELLQSG------------------------AIMNKFYQPHEAHIPYLLQLFIDYN-------LYGMNLIN--LAAVKFR-------KARRKSNTLHATGSC----------------------KNHLSGNSLADTLFRWEQDEIPSSLILEGV-------EPQSTCELEVDAVAADILN-RLDIEAQIGG---N----PGLQAIWEDEKQRRRNRNETSQMSQPESQDHRFVPATESEKKFQKRLQEILKQNDFSVTL
SGSVDYSDGSQEFSAELTLHSEVLSPEMLQCTPANMVEVHKDKESS--KGHTRHKVEEALINEEAILNLMENSQTFQPLTQRLSESPVFMDSSPDEALVHLLAGLESDGYRGERNRMPSPCRSFGNNKYPQNSDDEENEPQIEKEEMELSLVMSQRWDSNIEEHCAKKRSLCRNTHRSSTEDDDSSSGEEMEWSDNSLLLASLSIPQLDGTADENSDNPLNNENSRTHSSVIATSKLSVKPSIFHKDAATLEPSSSAKITFQCKHTSALSSHVLNKEDLIEDLSQTNKNT--EKGLDNSVTSFTNESTY-SMKYPGSLSSTVHSENSHKENSKKE-ILPVS-SCE--SSIFDYEEDIPSVTRQVPSR-KYTNIRKIEKDSPFIHMHRHPNENTLGKNSFNFSDLNHSKNKVSSEGNEKGNSTALSSLFPSSFTENCELLSCSGENRTMVHSLNSTADESGLNKLKIRYEEFQEHKTEKPSLSQQAAHYMFFPSVVLSNCLTRPQKLSPVTYKLQPGNKPSRLKLNKRKLAGHQETSTKSSETGSTKD----NFIQNNPCNSN-PEKDNALASDLTKTTRGAFENKTPTDGFIDCHFGDGT---LETEQSFGLYGNKYTLRAKRKVNYETEDSESSFVTHNSKISLPHPMEIGESLDGTLKSRKRRKMSKKLPPVIIKYIIINRFRGRKNMLVKLGKIDSKEKQVILTEEKMELYKKLAPLKDFWPKVPDSPATKYPIYPLTPKKSHRRKSKHKSAKKKTGKQQRT-NNENIKRTLSFRKK-RSHAILSPPSPSYNAETEDCDLNYSDVMSKLGFLSERSTSPINSSPPRCWSPTDPRAEEIMAAAEKEAMLFKGPNVYK-KTVNSRIGKTSRARAQIKKSKAKLANPSIVTKKRNKRNQTNKLVDDGKKKPRAKQK--TNEKGTSRKHITLKDEKIKSQSGAEVKFVLKHQNVSEFASSSGGSQLLFKQKDMPLMGSAVDH----PLSASLPTGINAQQKLS-GCFSSFLESKKSVDLQTFPSSRDDLHPSVVCNSIGPGVSKINVQRPHNQSAMFTLKESTLIQKNI-FDLSNHLSQVAQNTQISSGMSSKIEDNANNIQRNYLSSI-------GKLSEYRNSLESKLDQAYTPNFLHCKDSQQQIVCIAEQSK-------HSETCSPGNTASEES-QMPNNCFVTSLRSPIKQIAWEQKQRGFILDMSNFKPERVKPRSLSEAISQTKALSQCKNRNVSTPSAFGEGQSGLAVLKELLQKRQQKAQNANTTQDPLSNKHQPNKNISGSLEHNKANKRTRSVTSPRKPRTPRSTKQKEKIPKLLKVDSLNLQNSSQLDNSVSDDSPIFFSDPGFESCYSLEDSLSPEHNYNFDINTIGQTGFCSFYSGSQFVPADQNLPQKFLSDAVQDLFPGQAIEKNEFLSHDNQKCDEDKHHTTDSASWIRSGTLSPEIFEKSTIDSNENRRHNQWKNSFHPLTTRSNSIMDSFCVQQAEDCLSEKSRLNRSSVSKEVFLSLPQPNNSDWIQGHTRKEMGQ----SLDSANTSFTAILSSPDGELVDVACEDLELYVSRNNDMLTPTPDSSPRSTSSPSQSKNGSFTPRT--ANILKPLMSPPSREEIMATLLDHDLSETIYQE-PFCSNPSDVPEKPREIGGRLLMVETRLANDLAEFEGDFSLE-GLRLWKTAFSAMTQNPRPGSPLRSGQGVV--NKGS-SNSPKMVEDKKIVIMPCKCAPSRQLVQVWLQAKEEYERSKKLPKTKPTGVVKSAE--------NFSSSVNPDDKPVVPPKMDVSPCILPTTAHTKEDVDNSQIALQAPTTGCSQ---TASESQMLPPVASASDPEKDEDDDDNYYISYSSPDSPVIPPWQQPISPDSKALNGD--DRPSSPVEEL-PSLAF-
ENFLKPIKDGIQKSPCSEPQEPLVISPINTRARTGKCESLCFHSTPIIQRKLLERLPEAPGLSPLSTEPKTQKLSNKKGSNTDTLRRVLL-TQAKNQFAAVNTPQKETSQIDGPSLNNTYGFKVSIQNLQEAKALHEIQNLTLISVELHARTRRDLEPDPEF---------------DPICALFYCIS---SDTPLPDTE-KTELTGVIVIDKDKTVFSQDIRYQTPLLIRSGIT-GLEVTYAADEKALFHEI-----------------ANIIK-RYDPD----------------------ILLGYEIQMHSWGYLLQR------------------------------------------------------------------------------------------------------------------------AAALSIDLCRMISRVPDDKIEN-----------------------------------------------------------RFAAERDEYGSY-TMSE---IN---------------IVGRITL--N-LWRIM-RNEVAL-----T--NYTF---------ENVSFHV-L----------------------HQR---------------------------------------------------------------------------------------------------FPLFTFRV--LSDWFDNK-----------TDL------YRWKMVDHYVSRVRGNLQMLE--QLD----------------------------LIGKTSEM-ARLFGIQFLHVLTRGSQYRVESMMLRI--------------------------AKPMNYI--PVTP----------------SVQQRSQ----------------------------MRAP------------------------------------------QCVPLIMEPE-SRFY-----------------------------------------------------------------SN-SVLVLDFQSLYPSIV-----IAYNYCFST------------------------------------------C----LG--HVENLGKY-----DEFKFGCTSLRVPPDLLYQVRHD----ITVSP---------------------------------------------------------------------------------------------------NGVAF---VKPS-------------------VRKG--VLPRMLEEILKTRFMVK-----QSMKAY-----------------KQD--RAL-SRMLDARQLGLKLIANVT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FGYTSANFSGRMPCIEVGDSIVHKARETLERA-IKLVND----------------------------------------------------------------------------------TKKWG--A-RVVYGD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TDSMFVL----------------------LKG-ATKEQS---FKIGQEIAEAVTATN----PKP-------------VKLKFEKVY-LPCVL-------QT-KKRYV-------GYMYETLD--QKDPVFDAKGIETVRRDSCPAVSKILERSLKLLFE---TRDISLI------------------------
KQYVQRQCMKLL--EGKASIQDFIF------AKEY-RGSFSYKPGACVPALEL--TRKML----TYDRRSE-P--QV---------------------------------------------------------------------------------------------------------GERVPY---VII----------------------------------YGTP-GVP----------------------LIQLVRRPVEVLQDPT--------------------------LRLNATYYIT----------------KQILP--PLARIFSL----------------------------------------------------------------------------------------------I----------GIDVFSWYHELPRI----------------------------------------HKATSSSRSEPEGR------------------KGTISQYFTT---------------------------------------------------------------------------------------------------------LHCPVCD--------------------------------------------------------------------------------------DLTQHGICSKCRSQ--PQHVA-----------------------------------------------------------------------------------------------------VILNQEIRELERQQEQLVKICKNCTGCFDRHIP-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CVSLNCP----------VLFKLSRVNRELSKAPYLRQLLDQF------------------------------------------------------------Mus_zeta--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MFSVRIVTADYYMAS----------------PLPGL----DTCQSP---L--------------TQLPVK--------KVPV---VRVFGATP-AG------QKTCLH------LHG--------IFPYLY----VPYDGYG-QQ---PE-----------------------SYLSQMAFSIDRALN-----------VALGNPSSTAQHVFKVS--LVSGMP--F-YGYHE------KERHF-M---KIYL-YN---PAMVKR-----ICELLQSG------------------------AIMNKCYQPHEAHIPYLLQLFIDYN-------LYGMNLIN--LAAVKFR-------KARRKGNASHATGLF----------------------KHQLSGNSPAGTLFRWEEDEIPSSLLLEGV-------EPLSTCELEVDAVAADILN-RLDIEAQIGG---N----PGLQAIWEDEKQRRRNRNESSQISQPESQDCRFVPATESEKQFQKRLQEVLKQNDFSVTLSGSVDYSNGSQEFSAELTLHSEILSPEMLPCSPANMIEVHKDTDLS--KGNTKHKVEEALINEEAILNLIENSQTFQPLTQRLSETPVFMGSSPDESLVHLLAGLESDGYQGEKNRMPLPCHSFGESQNPQNSDDEENEPQIEKEEMELSVVMSQRWDSDIEEHCAKKRSLCRNAHRSSTEEDDSSSEEEMEWTDNSLLFANLSIPQLDGTADENSDNPLNNENSRAHSSVIATSKLSVRPSIFHKDAATLEPPSSAKITFQCKHTSALSSHVLNKDGLTEDLSQPN-ST--
EKGRDNSVT-FTKESTY-SMKYSGSLSSTVHSDNSHKEICKKDKSLPVS-SCE--SSVFDYEEDIPSVTRQVPSR-KYSNMRKIEKDASCIHVNRHISETILGKNSFNFADLNHSKRKLSSEGNEKGNSTSLSGVFPSSLTENCDLLPSSGENRSMAHSLESITDESGLNKLKIRYEEFQEHKMEKPSLSQQAAHYMFFPSVVLSNCLTRPQKLSPVTYKLQSGNKPSRLKLNKKKLIGLQETSTKSTETGATKD----SCTHNDLYTGA-SEKENGLSSDSAKATHGTFENKPPTEHFIDCHFGDGS---LEAEQSFGLYGNKYTLRAKRKVNYETEDSESSFVTQNSKISLPHPMEIGENLDGTLKSRKRRKMSKKLPPVIIKYIIINRFRGRKNMLVKLGKIDSKEKQVILTEEKMELYKKLAPLKDFWPKVPDSPATKYPIYPLTPKKSHRRKSKHKSAKKKPGKQHRT-NSENIKRTLSFRKK-RTHAVLSPPSPSYIAETEDCDLSYSDVMSKLGFLSERSTSPINSSPPRCWSPTDPRAEEIMAAAEKESMLFKGPNVYNTKTVSPRVGKASRARAQVKKSKARLANSSVVTNKRNKRNQTTKLVDDGKKKPRAKQKQRANEKSLSRKHAIPADEKMKPHSEAE--LTPNHQSVSELTSSS-GAQALSKQKEMSQTGPAVDH----PLPPAQPTGISAQQRLS-NCFSSFLESKKSVDLRTFPSSRDDSHSSVVYSSIGPGISKINIQRSHNQSAMFTRKETTLIQKSI-FDLSNHLSQVAQSTQVCSGIISPKTEESSSTQKNCGSSM-------GKLNEYRSSLESKPEQVCAPNFLHCKDSQQQTVSVSEQSK-------TSETCSPGNAASEES-QTP-NCFVTSLKSPIKQIAWEQKQRGFILDMSNFKPEKVKQRSLSEAISQTKALSQCKNQNVSTPSVFGEGQSGLAVLKELLQKRQQKAQSTNVVQDS-TSTHQPDKNISVSNEHKKANKRTRPVTSPRKPRTPRRTKPKEQTPRRLKVDPLNLQTSGHLDNSLSDDSPILFSDPGFESCYSLEDSLSPEHNYNFDINTIGQTGFCSFYSGSQFVPADQNLPQKFLSDAVQDLFPGQAIDKSELLSHDRQSCSEEKHHVSDSSPWIRASTLNPELFEKVAMDNNENHRHSQWKNSFHPLTSHSNSIMESFCVQQAENCLTEKSRLNRSSVSKEVFLSLPQANSSDWIQGHNRKEADQ----SLHSANTSFTTILSSPDGELVDAASEDLELYVSRNNDVLTPTPDSSPRSTSSPLQSKNGSFTPRT--AHILKPLMSPPSREEIVATLLDHDLSEAIYQE-PFCSNPSDVPEKPREIGGRLLMVETRLPNDLIEFEGDFSLE-GLRLWKTAFSAMTQNPRPGSPLRNGQAVV--NKES-SNSHKMVEDKKIVIMPCKYAPSRQLVQAWLQAKEEYERSKKLPKTELTPVTKSAE--------NVSPSLNPGDTCAVSPQVDKCPHTLSSSAHTKEEVSKSQIALQTSTTGCSQ---T------LLAAASAAVPEEDEDDNDNCYVSYSSPDSPGIPPWQQAASPDFRSLNGD--DRHSSPGKEL-CSLAV-ENFLKPIKDGIQKSSCSESWEPQVISPIHARARTGKWDPLCLHSTPVMQRKFLEKLPEATGLSPLSVEPKTQKLYNKKGSDADGLRRVLLTTQVENQFAAVNTPKKETSQIDGPSLNNTYGFKVSIQNLQEAKALHEIQNLTLISVELHARTRRDLQPDPEF---------------DPICALFYCIS---SDTPLPDTE-KTELTGVIVIDKDKTVTHQDIRSQTPLLIRSGIT-
GLEVTYAADEKALFQEI-----------------TNIIK-RYDPD----------------------ILLGYEIQMHSWGYLLQR------------------------------------------------------------------------------------------------------------------------AAALSVDLCQMISRVPDDKIEN-----------------------------------------------------------RFAAERDDYGSD-TMSE---IN---------------IVGRITL--N-LWRIM-RNEVAL-----T--NYTF---------ENVSFHV-L----------------------HQR---------------------------------------------------------------------------------------------------FPLFTFRV--LSDWFDNK-----------TDL------YRWKMVDHYVSRVRGNLQMLE--QLD----------------------------LIGKTSEM-ARLFGIQFLHVLTRGSQYRVESMMLRI--------------------------AKPMNYI--PVTP----------------SIQQRSQ----------------------------MRAP------------------------------------------QCVPLIMEPE-SRFY-----------------------------------------------------------------SN-SVLVLDFQSLYPSIV-----IAYNYCFST------------------------------------------C----LG--HVENLGKY-----DEFKFGCTSLRVPPDLLYQIRHD----VTVSP---------------------------------------------------------------------------------------------------NGVAF---VKPS-------------------VRKG--VLPRMLEEILKTRLMVK-----QSMKSY-----------------KQD--RAL-SRMLNARQLGLKLIANVT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FGYTAANFSGRMPCIEVGDSIVHKARETLERA-IKLVND----------------------------------------------------------------------------------TKKWG--A-RVVYGD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TDSMFVL----------------------LKG-ATKEQS---FKIGQEIAEAVTATN----PRP-------------VKLKFEKVY-LPCVL-------QT-KKRYV-------GYMYETLD--QKEPVFDAKGIETVRRDSCPAVSKILERSLKLLFE---TRDISLI------------------------KQYVQRQCMKLV--EGKASIQDFIF------AKEY-RGSFSYRPGACVPALEL--TRKML----AYDRRSE-P--RV---------------------------------------------------------------------------------------------------------GERVPY---VII----------------------------------YGTP-GLP----------------------LIQLIRRPAEVLQDPT--------------------------LRLNATYYIT----------------KQILP--
PLARIFSL----------------------------------------------------------------------------------------------I----------GIDVFSWYQELPRI----------------------------------------QKATSSSRSELEGR------------------KGTISQYFTT---------------------------------------------------------------------------------------------------------LHCPVCD--------------------------------------------------------------------------------------DLTQHGICSKCRSQ--PQHVA-----------------------------------------------------------------------------------------------------IILNQEIRELERKQEQLIKICRNCTGSFDRHIP-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CVSLNCP----------VLFKLSRVNRELSKAPYLRQLLDQF------------------------------------------------------------Latimeria_zeta--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MFAVRIVTADYYLAT----------------PLKGL----DVCYSE---F--------------RKAEVR--------KVPV---VRIFGATP-AG------QKTCLH------LHG--------VFPYIY----VPYDGCG-QQ---LE-----------------------RHLRQLAFSIDRALN-----------VALGNPSSSIQHVFKVS--LVSGTP--F-YGYHE------KEQQF-M---KIYL-YN---PLMVKR-----VCELLQGG------------------------AIMNKSYQPHEAHLPYLLQLFIDYN-------LYGMNLIN--LASIKFR-------KARRKDETQQEGTLCDDRDKTLRNRVSTNLWKSPATSKAHLSGSFIGGTFVQWEEDEIPSPLVLEGV-------ERQSTCQLEVDAVAADILN-RLEIEAQVGR---N----PGLQSIWEDEKQRRREKNESSQIEPPESQDRGFMQATDSEKVFKKRLKEILKQNDFSVTLSGSIDGSEGSELFPEELTLHSEVLSPGTLLCTPASQVEVHKDEESAIRVGNAKEE-EPPIVNEEAILNIMESSQIFQPSSQRLIQSPI-LESSQDQALAHLLAGLQDDGYQAGRLRQLSQHQFSGNCSYFQNSDDEENEPEIEKKEAELSLIMSQSWDSNISDRGAKTKHSGKSINESSTEEENENSEEEMEWSGNSSLFANLSIPQLDGAADESSDNALNESGSRTHSSVTATRKLLVKNSIFHKEAATLETQSAAKIGLQCGHDCGHSAHTLNEDSFAEPFQQPNSLTLIETQTELPVCSIIKERIYTSSKYPTSHTITLHTKNSGMDMDKSN--MPLDYSCDKKSSPCKPEEDMSLQNKRLQKRKKYTSITNLEKSAALMSKN---CESGLYWKPYNFSELNKLSGKVPPELHLKESSSFINKPLVSCRTEDFRVLCCPEVERSTVSAGESSTDEGSFGKLRIRYENFQEYKSEITSFSQQETHYKFFPSVVLSNCLDRSEKVISLPCKLQQVDRHSRLKLKKKKLNLVSQNAKEPVLANDKADGSAIAFTQPNACSSNISEESRPLSPNLAH
DNDTSVASVTPANR-LSLHIEEESPLQLDSEKAFSSCGSKYTLRTKRKINYETEDSESSLGSQNSRTSHLQFRTSTQNPDNSQQHWKRKKIRE--PPVIIKYIIVNRFKGRKNMLVKIGKVDSKEDSVTLNEHRMETYKKLAPLKDFWPKVPDSLATKYPVYPLTPKKIQKKKTKAKPSLKKKCKNLRNVDGKNTERTVPSKRKISSFSTLSPPLPCYTAEAEDCSPEYTDVMYKLGFLTERSPSPDKPSPPRCWSPSDPQAAELYEPSQGASLQRKGSGVLR-----KGAGARKPKKQPIKKSNII---PKTTSKKKNKNKQAKETEESVKNKKKEKQKKKSNEKRKAQKSLALTGEGPCGTNVVE--FVSEVQAQSGVLDFK-SSQPMFSQQDVSLTGHSMGHLPSTQLPCTQPLSTDSSQGNSPSCVRSLLEVSDSASLQEFSSPHEVGPSPKSSSHIRAGVQK-SPQINSKRSNISTISESSYFFEGIPFDSSTCHGQKVQHSQISLDSNFGRSSDSKDIQNNQYPTVPFPCRPYSQNGIMRSALPLKIK-----DFQFKSNSQQHLLFIQQPPRLFECPSSHGALVLPTSEESHESLHLPAEFSVSAVRSPVKQMGWEQKESGNILDISNFTFESKKQTSVSETTCSTIAQGKNGGKSLLT----NEGQSGLAVLKELLQKKRQKASSP---QEHLSSPPLNRITSCPIVQNMTKNKKPRSTTPSKKPRAPRNTKPKDKKSKSPKNEKVKQNDNTKADHPMSDISPVFLSDPGFESCYSLDDSLSPEHNYRFDINTLGQSEFCSLYSGSQFVPAYQNLPQKFLSD-VQDPVPGQAVTENNL--------EEDEQLHSQPIGRLSPGTLSPDLFDKYSPEIVEKAHLSNTDNHFSSHSSLVSPLLEATISQQPKPSTIDKRRRSSNSLYKEVFCCLPPVERQDLIENVNRKEFSSDVYMSFYSAETSLTGMMCSPNGDLVEGIDDDLEAPGSRRNYALTPTPNSSPRSISSPSQTKNGSLSSRTAGAHILKPLMSPPSRDEIMATLLDHDLTETNYQE-PFCSDPADAPEKPREIGGRVLMVETRLPDDLPEFEGDFSLE-GLQFWKTAFSVMTQNIRPTSPPLNGYSPIAAQKLE-RVNHSSTKDRKVIVMPCKSAPSCQRVHLWLQAKKEYERSKKC-KMEPAAEVDKAEQNQLMEDGNTSSHTEMAKAEAVTPVIGTGKPLEHKAIHCTRTKEEPASPIQISPIEVNESIKSPNSAQLELAVKPTEESCEEEKEEDDYYGNYSSPDSPVLPPWQQSPSPDARHCDPNELDGNKQELHTL-PSSPIGEDFVSEPHQHLPQYTKRESVKGLSSSLAQINAADAR-KSVYLHSTPVTQRRSREAAPEELCFTPISTDLRSQKLSQRRSSNADNLRRVLLTTQMKNQFTTLSQPKKESSQIEGPSLNNSYGFKVSIQNLQDAKALHEVQYLTLFSMELHARTRRDLEPDPEF---------------DPICAVFYCIS---SDAPLPNSN-KTEITGAIVVNKDFSTSSQGVRGQAPLLVRSGIT-GLQVTYTSDEKHLFEEV-----------------VKIMR-RFDPD----------------------ILLGYEVQMHSWGYLLQR------------------------------------------------------------------------------------------------------------------------AAAVEVDLCKMVSRVPDDKEN------------------------------------------------------------
RFAAERDEYGAD-TMSE------------------INVIGRVVL--N-IWRIT-KSEVAL-----N--NYTF---------ENVAFHV-L----------------------HQR---------------------------------------------------------------------------------------------------YPLFTFRV--LSDWFDNK-----------TDL------YRWKMVDHYISRVRGNLQLLQ--QLD----------------------------LIGRTSEL-ARLFGIQFYHVLTRGSQYRVESMMLRV--------------------------AKPMNYI--PVTP----------------SIQQRAQ----------------------------MRAP------------------------------------------QCVPLVMEPE-SRFY-----------------------------------------------------------------SN-SVLVLDFQSLYPSIV-----IAYNYCFST------------------------------------------C----LG--HVESLGKY-----EEFRFGCASLQVPPDLLYHLRND----ITVSP---------------------------------------------------------------------------------------------------NGIAF---VKQS-------------------VRKG--VLPSMLEEILKTRIMVK-----QSMKAH-----------------KDD--KAL-IRMLDARQLGLKLIANVT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FGYTAANFSGRMPCVEVGDSIVHKARETLERA-IKLVND----------------------------------------------------------------------------------TKKWG--A-RVVYGD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TDSMFVL----------------------LKG-ATKEQA---FKVGQEIAEAVTATN----PKP-------------VKLKFEKVY-LPCVL-------QS-KKRYV-------GYMYETID--QKDPVFDAKGIETVRRDSCPAVAKILERSIKLLFE---TRDISQI------------------------KQYVQRQCMKLL--EGKSSMQDLIF------AKEY-RGSASYRPGSCVPALEI--TRKML----AYDRRSE-P--RV---------------------------------------------------------------------------------------------------------GERVPY---VIV----------------------------------YGVP-GVP----------------------LIQLVRRPIEVLQDPS--------------------------IRLNATYYIT----------------KQILP--PLNRIFSL----------------------------------------------------------------------------------------------I----------GIDVFSWYHELPRV----------------------------------------QKASSTARSDQEGR------------------KGTISQYFTT-----------------------------------------------------------------------------------------------
----------LHCPVCD--------------------------------------------------------------------------------------ELTQHGICSKCRSQ--PQQVA-----------------------------------------------------------------------------------------------------VILNQEIREWERKQDQLLKICKNCVGCIDRQIQ-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CVSLNCP----------VLYKLSRVSREVSKAPYLRQLLDQF------------------------------------------------------------Drosophila_zeta----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAAAGEAIDGVYSVRLVIADFYMEK----------------PQFGM----DPCYSE---L--------------RGKEIK--------RVPV---IRVFGGNS-RG------QKTCMH------VHG--------VFPYLY----IPYDKKDFES---LE-----------------------RGILQMAMHLDKAIN-----------ISLGQGSSNAQHVFKIQ--LVKGIP--F-YGYHR------VEHQF-L---KIYM-FN---PRFVRR-----AANLLQSG------------------------AILSKNFSPHESHVPYILQFMIDYN-------LYGMSYVHVPLEVLKFR-------RNHDDD-------------------------------------------VIPYANVKQAQLLDITTA-------KKVACSALEVDVSSNFILN-RFQLVAKSKSNHTN----PGIEAIWNDEKLRRQKLVE-KHTDAGDEEKAEAVPVLELPPTQERHQIEIAESDIFYRT------------------ALESKLMT------------------------------LEQSTLSEQTL-----SDQTILPQATMQTTMP---------------------GTKAQKRRFNLQ-KLLANAVYPEECSQDQQQ-------------------------------------------------------------------------------------------------LLVNASFIQNHVT-------------CGYSSSVSLSTSKDE---------------SDDLDETVV----------------------------------------------------DEELIL-------------------------------------------SLTQPHGAIPHDATLRE--------------EDLELL----------------------DALQLLEEQ------------------------------NESESHVDLDSSLAPLSQHKKFELTPELLD--KETAATAALFDEDVD----------------SDE------DADQETRHDFSTV------------------LDDVDELLL-----------------------------KLTQSQPAESKELKASS----------------------------------KLPQIDGADDRL-----------QRTPIKSISSKSKSSP-SKTPTTPIGQKSLPKSPRTPKTSAAKK---------------------------------------------YAPLALTIG-----SSSSKKSNDEFAGRPSNPRLSLQLDQGTGTGTLRPEISLRK------
KLAMSEMRRKSFEDSFVLL--KNDCTPVRSTRRSTSNL-----------------DKTHIICSLTPRDRNP-------------------------GLSDMFETED--------GK----QLPPK-------------KVVRKTRWSTRNQDIESLPKAGCEIERP--HRSEGSALDELKPRRSARHK-----------------------------------VNSANPDECSSEIQTTGPRV----------------------------------------------------------------------------TTTSLDRPQKKARLSQ------------SPKENTKTSMNGTVALEKATKDSSSNS--------------------------------------ESPHQQENSVSEQIEYLE----SKPKKSDETARSCDEKLQRELIPQEP--AGISPGDSANSTEEIT-----------FSPCH--DEAIESDTESDYIVTKLRKT------------PNLKRLR------------------------------------------W----SIRSELLNK----------------QFTPSSGIRPPETETTPQLSPKSNESNTPELMRSFYEHSLIVNSPSV----------------------------FSDFLDSPEIHM------------------------DSPRSAPPSPDSN----------SFVIAPLELPPSYDEVVSGSRKMDIPEYEFQK-PYYSNPSDVS-KVTEVGFLVLHIPGNKLNDCDPFQSILGNDRGLASWR----------RRQLIAIGGLAMLQRHRGEQKVREYFSTQQRIAIEPAQLAPTWQEAKIWLKAKE----------------------------------------------------LLRQREEPKKSSDDIDSPIKIK---------------------------------------------------RQKITMMLQAEEGDGGSGDEDAGEELDCSLSL--------------TPLSQAKDKCKATPTSSKARETG--------KSRLKRGTRLSFIGSQDEEPPSSQSSEQSVSS--SAAQAELDRSSFLRQLEG--SSQDRQHDLSFGLSHATLDNTFGFKVNLENLQQAKADIDCNHLTIITLEVFVSTRGDLQPDPMH---------------DEIRCLFYAI-----EHSLPDEKLPSKACGYIMVN-----TVQDLLSEGPF---HGIDRDIEVQVVTSEAEAFEAL-----------------LALCE-RWDAD----------------------IYAGYEIEMSSWGYVIDR------------------------------------------------------------------------------------------------------------------------AKHLCFNIAPLLSRVPTQKV-------------------------------------------------------------RDFVDEDREQFT-DLDV-----------------EMKLCGRILL--D-VWRLM-RSEIAL-----T--SYTF---------ENVMYHI-L----------------------HKR---------------------------------------------------------------------------------------------------CPWHTAKS--LTEWFGSPC-------------------TRWIVMEYYLERVRGTLTLLD--QLD----------------------------LLGRTSEM-AKLIGIQFYEVLSRGSQFRVESMMLRI--------------------------AKPKNLV--PLSP----------------SVQARAH----------------------------MRAP------------------------------------------EYLALIMEPQ-SRFY-----------------------------------------------------------------AD-PLIVLDFQSLYPSMI-----IAYNYCFST------------------------------------------C----LG--RVEHLGGS-----SPFEFGASQLRVSRQMLQKLLEH--
DLVTVSP---------------------------------------------------------------------------------------------------CGVVF---VKRE-------------------VREG--ILPRMLTEILDTRQMVK-----QSMKL------------------HKD--SSALQRILHSRQLGLKLMANVT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YGYTAANFSGRMPSVEVGDSVVSKGRETLERA-IKLVEN----------------------------------------------------------------------------------NEEWK--V-RVVYGD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TDSMFVL----------------------VPG-RNRAEA---FRIGEEIAKAVTEMN----PQP-------------VKLKLEKVY-QPCML-------QT-KKRYV-------GYMYETAD--QEQPVYEAKGIETVRRDGCPAVAKMLEKVLRILFE---TQDVSKI------------------------KAYVCRQFTKLL--SGRANLQDLIF------AKEF-RGLNGYKPTACVPALEL--TRKWM----QKDPRHV-P--RR---------------------------------------------------------------------------------------------------------GERVPF---IIV----------------------------------NGPP-GMQ----------------------LIRLVRSPHDILANEG--------------------------HKINAIYYIT----------------KAIIP--PLNRCLLL----------------------------------------------------------------------------------------------I----------GANVHDWFASL-PRKLLMTP----------------------------------AVGTANELAGARGA------------------KSTISQYFST--------------------------------------------------------------------------------------------------------TSCVIDCG--------------------------------------------------------------------------------------RQTKAGICPDCLKN--ATTCV-----------------------------------------------------------------------------------------------------VVLSDKTARLERGYQLTRQICQACCGRLGSLQ--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CDSLDCP----------VLYVLEGKRRELQQIEHWNKLLEHHF-----------------------------------------------------------
Arabidopsis_zeta-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MADSQSGSNVFSLRIVSIDYYMAS----------------PIPGY----NICYSS---F--------------QGSEVNE--------VPV---IRIYGSTP-AG------QKTCLH------IHR--------ALPYLY----IPCSEIPLEHHKGVD-----------------------GSTLALSLELEKALK------------LKGNAASKRQHIHDCE--IVRAKKF---YGYHS------TEEAF-V---KIYLSYH---PPDVAR-----AASLLLAG------------------------AVLGKSLQPYESHIPFILQFLVDYN-------LYGMG--------HVHISKMKFRSPVPHHFRPRRFDLDDCPGQRIDEVAITKANSSAAASVSFPVWSLSTIPGQWMWNLSEESDTPLSQSQHRHQHHYRRQSLCELEGDATSSDILNQQFKMYNSLSQAQSDTNMVQSLVAIWEEEYERTGVHDAPIPPDPGKPSAADVLQTMSDYVGFGNMLKEMLNKVELSPPGMKPTAVSSAGPDMHAKPEITDLQALNHMVGTCSEFPASEQLSPLGEKSEEASMENDEYMKTPTDRDTPAQIQDAEALGLFKWFASSQAAEDINSDDEILR------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ETILSPLLPLASINKVLEMASTDYVSQSQKECQDILDSQENLPDFGSSTKRALPSNPDSQNLRTSSDKQSLEIEVASDVPDSSTSNGASENSFRRYRKSDLHTSEVMEYKN-------------------------------------------------------------------------------------------------------------------------------------------------------------------RSFSKSNKPSNSVWGPLPFTLTKNLQKDFDSTNASDKLGLTKISSY---------------------------------------------------------------------------------------------------------------------------------PMNEMT-------------------------------------------------------------DNYIVPVKEHQADVCNTIDRNVLAGCSLRDLMRKKRLCHGESPVSQHMKSRKVRDSRHGEKNECTLRCEAKKQGPALSAEFSEFVCGDTPNLSPIDSGNCECNISTESSELHSVDRCSAKETASQNSDEVLRNLSSTTVPFGKDPQTVESGTLVSS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NIHVGIEIDSVQKSGREQESTANETDETGRLICLTLSKKPPSLDCLSAGLQDSAHSHEIHAREKQHDEYEGNSNDIPFFPLEDNKEEKKHFFQGTSLGIPLHHLNDGSNLYLLTPAFSPPSVDSVLQWISNDKGDSNI--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DSEKQP---------------------------------------------------
LRDNHNDRGASFTDLASASNVVSVSEHVEQHNNLFVNSESNAYTESEIDLKPKGTFLNLNLQASVSQELSQISGPDGKSGPTPLSQMGFRDPASMGAGQQLTILSIEVHAESRGDLRPDPRF---------------DSVNVIALVVQ---NDDSFVAEVFVLLFSPDSIDQRNVDGLSGCK-----------------LSVFLEERQLFRYF-----------------IETLC-KWDPD----------------------VLLGWDIQGGSIGFLAER------------------------------------------------------------------------------------------------------------------------AAQLGIRFLNNISRTPSPTTTNNSDNKRKLGNNLLPDPLVANP--------------------------------------AQVEEVVIEDEW-GRTH---AS------------GVHVGGRIVL--N-AWRLI-RGEVKL-----N--MYTI---------EAVSEAV-L----------------------RQK---------------------------------------------------------------------------------------------------VPSIPYKV--LTEWFSSG-----------PAG------ARYRCIEYVIRRANLNLEIMS--QLD----------------------------MINRTSEL-ARVFGIDFFSVLSRGSQYRVESMLLRL--------------------------AHTQNYL--AISP----------------GNQQVAS----------------------------QPAM------------------------------------------ECVPLVMEPE-SAFY-----------------------------------------------------------------DD-PVIVLDFQSLYPSMI-----IAYNLCFST------------------------------------------C----LG--KLAHLKMN-----T---LGVSSYSLDLDVLQD-LNQ----ILQTP---------------------------------------------------------------------------------------------------NSVMY---VPPE-------------------VRRG--ILPRLLEEILSTRIMVK-----KAMKK---------------LT-PSE--AVL-HRIFNARQLALKLIANVT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YGYTAAGFSGRMPCAELADSIVQCGRSTLEKA-ISFVNA----------------------------------------------------------------------------------NDNWN--A-RVVYGD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TDSMFVL----------------------LKG-RTVKEA---FVVGQEIASAITEMN----PHP-------------VTLKMEKVY-HPCFL-------LT-KKRYV-------GYSYESPN--QREPIFDAKGIETVRRDTCEAVAKTMEQSLRLFFE---QKNISKV------------------------KSYLYRQWKRIL--SGRVSLQDFIF------AKEVRLGTYSTRDSSLLPPAAIVATKSMK----ADP-RTE-P--
RY---------------------------------------------------------------------------------------------------------AERVPY---VVI----------------------------------HGEP-GAR----------------------LVDMVVDPLVLLDVDTP-------------------------YRLNDLYYIN----------------KQIIP--ALQRVFGL----------------------------------------------------------------------------------------------V----------GADLNQWFLEMPRL----TR----------------------------------SSLGQRPLNSKNSH------------------KTRIDYFYLS---------------------------------------------------------------------------------------------------------KHCILCG------------------------------------------------------------------------------------EVVQESAQLCNRCLQN--KSAAA-----------------------------------------------------------------------------------------------------ATIVWKTSKLEREMQHLATICRHCGGGDWVVQS----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVKCNSLACS----------VFYERRKVQKELRGLSSIATESELYPKCMAEWF----------------------------------------------------Leishmania_zeta------------------------------------------------------------------------------------------------------------------------------------------------------------MYMQVVSIEHSLERPHAALGDAALSPIFRRVSARCPVLHLFGYVHIPLDLTPTTSGTSAPVASTEPRDASSSAPENELDGDAEITAAATPHSFSRGSSGGGILLLSRATPLVGRLSGTPAPLQQEDASPSPKRATYALDADGHGNKAAAAGAVARHCDAPS----------------SSFLPPCSTLCAATS---A--------------AGGDGDPLILTDGNLGSS---AAWRGRYTQ--------RRACLH------VHG--------VYPSLL----LPQYDRS-------------------------------VSADQLAAQLEAVAL--------CVLARQGTLVPTQQLVHNVR--IAHRFNV---YGYRP------HAYAF-Y---EVEL-ID---PDLLPR-----VVDVLQNS-----------------------TEVGGRQWQLYDAHYRYHTQFMVRWRVSGIAPFLLPAGRCHVRLPTVAELSENSPALSASLEAVGRLQAPQHSRGNDSDAAKRELKDKDEEEHRQAAASSAQQSQLLFRQRWRPDELGRATTAEVELDVAGADLLDHSSAVEEGEAKGAAVAAQGRRRTVTAGDNLNYTRRIIRHYFSEHGVSDTLRVADTIAMERHQQECAHVAAAGLKGQQGRYGHVMQIQRGDPTVRWLRHRMLEYLKERAEANAAVAAALAAPSAVRKTEDGSEVSTAMFLASTGAAAASVLPLSSAASLVESAVKLQDQRAIRQQLLAEYRRPGGATLRASRHGHRRGATDAMSTRVYADGHIAVPSSFAHVADQESAIAGGEALYVGFSSE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
SLKLSVPQGQTQPQPQPQQPAAAPENAAGKPIPSSSAYQSFFDELSATAYADVVAAPTQDLFTALAQPSAPSLPSHGDEPTTSVAAAVITTPRRSSMSSKEASGADCRDMQPMLETTREPASNADVTLTCAASDSIIAAAPSRAGSSWSSALSSSSTASLSSGR---------------------------------------------------TSPDHGNSCMEGREGVDPSFLGSSAAQSRERAQGEPCLAALDAAALVRETPTQRPTRSSVGRSPKISEGQDDDFAFDALDRIDGEAIRPSVGASQKDGSLPRLGRDTSSAALDELVGAENDHTPEGGRRCAGIAAAASPATATPTRLLTRHDLAEGDCVAFVRVREVAPSLRHGEVLAMARVAALMTETTELQWLLRLSETHFAAEEQALVRRGSWLRAQLPTAAAAAASTAPSMRDYHSHFAGTARDVQLGEVVLSNVYDSVLTSVLEGYAQAAAPSAPTQQLPARDVAVSA---------------ARTLDIGEIDLKVRETDPEEGSVSWQLGRRRPSDDAAAEVQVWRVHCFTDVAVYHSFAGPPDGRHRPHAGHPSCSSPPLLRVLCRYAYHVEARVLTSVCPDVFTPDVRKSAVDCRPLPSSRRVLSHGDQQLESGERRVDAATAHHSSRTGASSSRVLFTQPQPLLPLGAPRAHSRAAAASLTSPPAPSSPPVEVPATLAKAP-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------WLEASEEGCEDTLLFPSSSASTGSSWGGGRDASKRGDEAASACAAHAAPLGVTHMPDRAPPQSASEASAELPSPSAAVQTSQDAADAAPPPAGKRLWRVSLMRTPPPDFAVGRMRVLRGVQAARHFAAHAFVSEKQAWLRQRGASCTTDGSHGPTADAAAVGAIEESDTAPQLRFSNETADPDGDGNEEQPVGATVRDGSRANGARSGGTLAAAGGRRATEIVVLSAASSCAHSSSAAPIASFVVSSLTPSRSSSSSVDPVREVTASQRGFLDLLQA----------------------------------------------------GRNLDEGGARMVLLQHRGQLGYMVDGMRRCCAVSASGSEGLLLSRGGGGGSSGDLRVCASAVAWPWTAATEVTPSDGALLPCRYEAVASFPAPSAGIAGASRGARVAPTAARGTPTRRGAKQSLLLSVVSRRKSTSHVPGLSLSATQQPQHHLQCTLR-VLYIEVLLHRLPGEAPASTNEVLAVGLGQATTATNSAIAVRVFCVAAPLRCAAARAATHPSAAGRAPPLVGLTEAVQ--------------------VVTMPDEAALLARV-----------------RGEIL-AYDPD----------------------ILISWDGFKYGLGYLALRYRAVFHRNLASDLSRVLQHHGYQRTNANCGSHFAAAASASGGDAGADGGAAERACPSMAEEGPAEGGRGGADAGELAAARYRSRSPASHAAASFTVRHGSSGGGGEPVPSQESVRSATAMAARSSVLSSAASSASWAAPLRDLDEDDDDVDGGGTDDAGAKGGARGCRGGALAGQTVEYREGRTMHWAPPALRRNGQPPLLARPRAALDLRAA-ASAP---AAAAADQYAKRFGTDIHVVGRICS--S-LGKDL-RKEIKM-----P--SYSL---------TMVHVKL-L----------------------GQP---------------------------------------------------------------------------------------------------
LPYFTDSY--LSELFLTP-----------QCADAPGGGERHTALRYLASRVAAPHRIAC--KLR----------------------------WFTRLLEF-SRMYGILTKEVITRGSQFRVEATLLRF--------------------------AHPLGYA--MLSP----------------SLSQVQR----------------------------QPRI------------------------------------------ECIPLVMQPK-SDLY-----------------------------------------------------------------RHDPVVVLDFRSLYPSLI-----IAYNLCYST------------------------------------------C----LG--LVQPHSHGRLGVLPRFRQSNAALAELLPDDGAQHDG--VVFSP-----------------------------------------------------------------------------------------------------NGAMF---VSPS-------------------TRVG--LLPQMVQAVLDTRFEVQ-----AALKH---------------IAVPSE--DITMQQRLQEQQLALKMLANVT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YGYTAASYTGRMPCVDLAEAIVSLGRQTLERA-IELIHS----------------------------------------------------------------------------------TPAWR--A-EVVYGD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TDSLFVR----------------------LAG-RTKADA---FRIGQEMADAVTRSN----PAP-------------IRLQFEKVL-LPCLL-------LV-KKRYA-------GYMWTSPT--QEAPTFLAKGIEVVRRDQCPATVQLTDRLLRMLLD---GASATAL------------------------RQSYYAAVERLQ--SGAANPLQCIF------RRAVKLG--RYKD-AGETHLPL--AARLAFQQMEKDVTQT-P--FW---------------------------------------------------------------------------------------------------------GERLPY---VVV----------------------------------QSTTAVNK----------------------LTDKVLHPERLLQAHDT-------------------------HSVDAAYYIV----------------RHVNR--TLDRMFCL----------------------------------------------------------------------------------------------V----------GIRFARWYQEMPRRRTAHAALLNLPTFMAAQQRLQRLQGVVPPDARGAAPLPFSFDTASAPLSPRSRQMRLGQLASLMEGLRHHHSSSGVLSALRG------GAASAAATTAATAEEISDDEDPSAEAAQLTEVADLTRPSTQEVIDVDQLATQRSNRPSSSLTGAAPPQLDRFLKPGRAASRSGRRKRWRTVTLESFYPRTLCVVCEEEAVSLNDISRQQAVLM
HVGGVGCGAAVS-----------------------------------GGRCSKVAYPPASTAPAAPLPLPHRLPPICTRCWSD--PLSLH-----------------------------------------------------------------------------------------------------LHVQQQCRSMHRQMNALQGLCARCISGGGDAGDAAADEYRLAVADMEDMDAFCMSSTLTRRRNCPGHGYDGV------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DGSTPRHVLAAVELSAEGVPRGCVSVDCA----------VGFEKKWVTAQRTQWQALQAFLNKVL-----------------------------------------------------------Saccharomyces_zeta-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSRESNDTIQSDTVRSSSKSDYFRIQLNNQDYYMSK----------------PTFLD----PSHGES---L--------------PLNQFSQ--------VPN---IRVFGALP-TG------HQVLCH------VHG--------ILPYMF----IKYDGQITDTSTLRH-----------------------QRCAQVHKTLEVKIRASFKRKKDDKHDLAGDKLGNLNFVADVS--VVKGIP--F-YGYHVG-----WNLFY-----KISL-LN---PSCLSR-----ISELIRDG------------------------KIFGKKFEIYESHIPYLLQWTADFN-------LFGCS-----------------------------------------------------------------------------------------------------------------------------------------WIN-VDRCYFRSPVLNSILDIDKLTINDDLQLLLDRFCDFKCNVLSRRDFPRVGNGLIEIDILPQFIKNREKLQHRDIHHDFLEKLGDISDIPVKPYVSSARDMINELTMQREELSLKEY-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KEPPETKRHVSGHQWQSSGEFEAFYKKAQHKTSTFDGQIPNFENFIDKNQ-----------------------------------------------------------------------------------------------------------------------------------------------------------------KFSAINTPYEALPQLWPR---------------------------------------------------------------------------------------------------LPQIEINNNSMQDKKNDDQVNASFTEYEICGVDNENEGVKGSNIKSRSYSWLPESIASPKDSTILL--------------------------------------------------------------------------------------------------------
---------DHQTKYHNTINFSMDCAMTQNMASKRKLRSSVSANKTSLLSRKRKKVMAAGLRYGKRAFVYGEPPFGYQDILNK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LEDEGFPKIDYKDPFFSNPVDLENKPYAYAGKRFEISSTHVSTRIPVQFGGETVSVYN----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KPTFDM-------------------------------------------------------------------------------------FSSWKYALKPPTYDAVQKWYNKVPSMGNKKTESQISMHTPHSKFLYKFASDVSGKQKRKKSSVHDSLTHLTLEIHANTRSDKIPDPAI---------------DEVSMIIWCLE---EETFPLDLDIAYEGIMIVHKASEDSTFPTKIQHCINEIP---------VMFYESEFEMFEAL-----------------TDLVL-LLDPD----------------------ILSGFEIHNFSWGYIIER------------------------------------------------------------------------------------------------------------------------CQKIHQFD-------IVRELARV----------------------------------------------------------KCQIKTKLSDTW-GYAH---SS------------GIMITGRHMI--N-IWRAL-RSDVNL-----T--QYTI---------ESAAFNI-L----------------------HKR---------------------------------------------------------------------------------------------------LPHFSFES--LTNMWNAK-----------KSTT-----ELKTVLNYWLSRAQINIQLLR--KQD----------------------------YIARNIEQ-ARLIGIDFHSVYYRGSQFKVESFLIRI--------------------------CKSESFI--LLSP----------------GKKDVRK----------------------------QKAL------------------------------------------ECVPLVMEPE-SAFY-----------------------------------------------------------------KS-PLIVLDFQSLYPSIM-----IGYNYCYST------------------------------------------M----IG--RVREINLT-----EN-NLGVSKFSLPRNILAL-LKN--D-VTIAP---------------------------------------------------------------------------------------------------NGVVY---AKTS-------------------VRKS--TLSKMLTDILDVRVMIK-----KTMNE---------------IG-DDN--TTL-KRLLNNKQLALKLLANVT-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
-------------------------------------------------------------------------------------------------------------------------------------------------------------YGYTSASFSGRMPCSDLADSIVQTGRETLEKA-IDIIEK----------------------------------------------------------------------------------DETWN--A-KVVYGD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TDSLFVY----------------------LPG-KTAIEA---FSIGHAMAERVTQNN----PKP-------------IFLKFEKVY-HPSIL-------IS-KKRYV-------GFSYESPS--QTLPIFDAKGIETVRRDGIPAQQKIIEKCIRLLFQ---TKDLSKI------------------------KKYLQNEFFKIQ--IGKVSAQDFCF------AKEVKLG--AYKSEKTAPAGAVVVKRRIN----EDH-RAE-P--QY---------------------------------------------------------------------------------------------------------KERIPY---LVV----------------------------------KGKQ-GQL----------------------LRERCVSPEEFLE-GEN-------------------------LELDSEYYIN----------------KILIP--PLDRLFNL----------------------------------------------------------------------------------------------I----------GINVGNW-----------AQ----------------------------------EIVKSKRASTTTTK------------------VENITRVGTS---------------------------------------------------------------------------------------------------------ATCCNCG----------------------------------------------------------------------------------EELTKICSLQLCDDCLEK--RSTTT-----------------------------------------------------------------------------------------------------LSFLIKKLKRQKEYQTLKTVCRTCSYRYTSDAG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IENDHIASKCNSYDCP----------VFYSRVKAERYLRDNQSVQREEALISLNDW-------------------------------------------------------Methanocella--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MIV----------------DLWHR----PSTDSQ---------------------------------HGA---YLLWLRTA-DG-------IICVE------DRE--------FRPSFS------------------------------------------VIPSTQARLVEQVVA-------------------QHENVARAE-----------------------TACRY-P---SIYA------ADQVPV-----IRAFMLDE------------------------RRAEETMREIRARAPAEVRFAEWKL-------
LPELQ-----------------------------------------------------------------------------------------------------------------------------------------WYY-LRRIPPH-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SLVAIEAEGGVL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QSIEYI-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GPADSE---------------------------------------------------------------------------------------------------------------------------------------------------------ALKVMAIY---------------------------PAFTTRVPANCRIQSITLRYGKEE--------------------------------------VAISGREEDVLAEM-----------------QRRLD-ACDPD----------------------AIAIFDADWETLPLLGLR------------------------------------------------------------------------------------------------------------------------AQDNNMRL-------------------------------------------------------------------------RLGRLPDPTKLYPPRGAVRHWQ----------AKQVRTPGRILL--D-LWKDA-RTDADL-----KRTGLDL---------DDV-----Y----------------------------------------------------------------------------------------------------------------------------GAEFHDRQ------------------------------KSPASMVYDLARERLPMLMSW------------------------------------------CHRCLMPLDSVCREKHGFMNASSVNST--------------------------LIESTVI-----P----------------DEPEYPE---------------------GFKTPLTEQLK------------------------------------------ENGGLVITPE-AGLH-----------------------------------------------------------------EN--VAIVDFSSLFPRIF-----VKHNISPET---------------------------------------------------
INCRHPEC-----RAHGERV----------------------------------------------------------------------------------------------------------------------------PFLDF---HICR-------------------KRKG--VYPVVFGKVLAERDAVK-----AKLKSL-----------------DPA--SEE-YRKLEMLYKSLKMQLVSP--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YGYMQF-ALNNFRSVDGNRSIPAYGRHYLLRA-RDIAED-------------------------------------------------------------------------------------AG--F-NVIYAD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TDSLFIQ-----------------------------GGD---RELYTAFCNRISA------DFG-------------LELKLEHVCRWVLFLPEHPGGKKGLKKKYF--------ASVDGE--------VLVRGLEVRRQDRAAITKKVQEHVLEILASANDATEFRAMIPKV--------------------AAYVRGEVARIQ--AGNVTPEELAI------VRKLSHRPEEYK--ALPHHAVA--AEALA------AKGRS-V--RV---------------------------------------------------------------------------------------------------------GGKVEY---IVT---------------------------------------GTN--------------------------KATPLALAGND---------------------------PEYDVASYVE----------------NTVH---PIYMLLRE---------------------------------------------------------------------------------------------------------------------------------------------------------------FGLKYEDLLPGPK-------------------QVGLDAFMGA----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DSICQV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Korarchaeum
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MRKIYFHIEDTEDQL----------------ELWFS----------------------------------------------------------GG------MSERVR-----------------FRPYFY----ILPEEEG-----------------------------------NLSGFLEKERV--------------------RKKVMGVE-------------------------RDL-V---KVYF-KD---ERSMKR-----AMKGLKNP---------------------------------METGIPSWFKFILDSG-------LIPFS---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DPDNPSESYGIE-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DLKKLF----------------------------------------------------------------------------------------------------------------------------FSGMIY---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SED----GFP------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VEGKSP---------------------------------------------------------------------------------------------------------------------------------------------------------IVAISYSVD--------------------------DGPIEVISASD-------------------------------------------------------LDDSVIIREF-----------------VSVIS-KENPD----------------------VIVGYGQDADEFKHLMAR------------------------------------------------------------------------------------------------------------------------SKNLGLRLSIG----------------------------------------------------------------------
RDGSEPMETGKF-FRGT---II----------V-ENRIRGRANL--D-LFSVAWRDFPQL-----P--ERTW---------YELADELGV----------------------GRP---------------------------------------------------------------------------------------------------EVMMKFR---VAEAWKL---------------------NRDNALDYMRKKLSTIIGIYS----K----------------------------IIDNQIAL-SKMSLIPIHKLLRSSVGEIVEAILLKE--------------------------SRSRDWI----AF----------------SSPQRPE------------------------------ES------------------------------------------YEGGFVWIKS-PGVY-----------------------------------------------------------------EG--ICYLDFASMYPSIM-----ALHNLSFET---------------------------------------------------VNPEEGFC-----EVEEVNV----------------------------------------------------------------------------------------------------------------------------EGVRA---KVCR-------------------DVEG--LVPQLVRKLIEERSKIK-----ESLANL-----------------KQD--DPE-YKRLDAAQRAIKVVTNAI--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YGYMGW-ESATFMNISAARLTSAYGRLYIKKV-RGMLES-------------------------------------------------------------------------------------KG--L-SVIYID------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TDGIQFL-----------------------------------GKECENVIDDINSGI----PLR-------------LDLRYKALR-GIYLA----------KKKYA-------HLLEDGR--------IIAKGFEFVRRDYPKIVKEAQREVVEAILR---GKESEI-------------------------EKIVNKFRDKII--KGDIKREDLII------FETIGKEEERFE--RMTKGLRV--STWLK----AEK-GIE-V--HR---------------------------------------------------------------------------------------------------------GQVLRI---III----------------------------------KGPG-SVT------------------------DRARPAEFFDV-----------------------------SDADLDYYLS-----------------LFDQ--VIERTLSP----------------------------------------------------------------------------------------------L---------------RV-----------------------------------------------QESK----------------------------KGGLEEWF------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Pyrococcus-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MIL----DVDYIT---E--------------EG-------------KPV---IRLFKKE--NG------KFKIEH------DRT--------FRPYIY----ALLRDDS--------------------------------KIEEVKKITGERHG----------------------KIVRIV--DVEKVEKKF-LG---------KPITV-W---KLYL-EH---PQDVPT-----IREKVREH---------------------------PAVVDIFEYDIPFAKRYLIDKG-------LIPME-----------------------------------------------------------------------------------------------------------------------------------------GEE------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ELKILA----------------------------------------------------------------------------------------------------------------------------FDIETL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YHEGE-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
EFGKGP---------------------------------------------------------------------------------------------------------------------------------------------------------IIMISYA----------------------------DENEAKVITWK---NIDLPY------------------------------------------VEVVSSEREMIKRF-----------------LRIIR-EKDPD----------------------IIVTYNGDSFDFPYLAKR------------------------------------------------------------------------------------------------------------------------AEKLGIKL-------------------------------------------------------------------------TIGRDGSEPKMQ-RIGD---MT------------AVEVKGRIHF--D-LYHVI-TRTINL-----P--TYTL---------EAVYEAI-F----------------------GKP---------------------------------------------------------------------------------------------------KEKVYADE--IAKAW-ES-----------GE-------NLERVAKYSMEDAKATYELGK--E------------------------------FLPMEIQL-SRLVGQPLWDVSRSSTGNLVEWFLLRK--------------------------AYERNEV----AP----------------NKPSEEE------------------------YQRRLRES------------------------------------------YTGGFVKEPE-KGLW-----------------------------------------------------------------EN--IVYLDFRALYPSII-----ITHNVSPDT------------------------------------------L----NL--EGCKNYDI-----A----------------------------------------------------------------------------------------------------------------------------------PQVGH---KFCK-------------------DIPG--FIPSLLGHLLEERQKIK-----TKMKE------------------TQD--PIE-KILLDYRQKAIKLLANSF--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YGYYGY-AKARWYCKECAESVTAWGRKYIELVWKELEEK-------------------------------------------------------------------------------------FG--F-KVLYID------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TDGLYAT----------------------IPG-GESEEI---KKKALEFVKYINS------KLPGL-----------LELEYEGFY-KRGFF-------VT-KKRYA-------VIDEEGK--------VITRGLEIVRRDWSEIAKETQARVLETILK---HGDVEEA------------------------VRIVKEVIQKLA--NYEIPPEKLAI------YEQITRPLHEYK--AIGPHVAV--AKKLA----AKGVKIK-P-------------------------------------------------------------------------------------------------------------
GMVIGY---IVL----------------------------------RGDG-PIS------------------------NRAILAEEYDPKK---------------------------HKYDAEYYIE----------------NQVLP--AVLRILEG----------------------------------------------------------------------------------------------F---------------GY-----------------------------------------------RKEDLRYQKTRQVG------------------LTSWLNIKKS------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Methanococcus----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDLDYNS----------------KDLCI----DMYYKN---C--------------GLK------------KPE---INLQKECE--------------------------------FKPYFY----VDTSEPKEIYDYLDG-----------------------LNQEIDLKKLEPEFE----NNTSLKVQDLITNIEIIEKIVYSDYILNGKDISEV-SDFKNK-----KERKI-C---KVYV-KY---PNHVKI-----IREYFKEF------------------------------GKSYEFDIPFLRRYMIDQD-------IVPSA-----------------------------------------------------------------------------------------------------------------------------------------KYS---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EDNKIDNSIP-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ELNCIA------------------------------------------------------------------------------------------------------
----------------------FDMELY--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CKKEP------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NAKKDP---------------------------------------------------------------------------------------------------------------------------------------------------------IIMVNLFSKDYQ----------------------------KVITYK---KFENSEYNGC--------------------------------------VDYVKDEKELIQKT-----------------IEILK-QYD------------------------VIYTYNGDNFDFPYLKKR------------------------------------------------------------------------------------------------------------------------ANIYEIELDFDNA--------------------------------------------------------------------SNSQQPQIIKIS-KGGI---NR------------KSKIPGIIHI--D-LYPIA-RKLLNL-----T--KYKL---------ENVVQEL-F----------------------KIN---------------------------------------------------------------------------------------------------KEAVDYGD--IPKMWET---------------------EDTTLLRYAYEDALYTYKMGN--Y------------------------------FLPLEIMF-SRIVNQPLYDTSRMNSSQMVEFLLLKR--------------------------SFEQNMI----SP----------------NRPSSSS------------------------YRERAKFS------------------------------------------YEGGYVREPL-KGIQ-----------------------------------------------------------------ED--IVSLDFMSLYPSIL-----ISHNISPET---------------------------------------------------VIYEEKER----------------------------------------------------------------------------------------------------------------------------------------ENMEL-----------------------------G--IIPKTLNELLSRRKHIK-----MLLKDKI----------------QKNEFDEE-YSRLEHEQKSIKVLANSH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YGYLAF-PMARWYSDKCAEMVTGLGRKYIQET-IEKAEE-------------------------------------------------------------------------------------FG--F-
KVIYAD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TDGFYAKWDYDKLQKGKKEENDKSDKLSNLPK-LSKEEL---IILTKKFLKGINEEL----PEG-------------MELEFEGHF-KRGLF-------VT-KKKYA-------LIEDDGH--------IVVKGLEVVRRDWSNIAKDTQQAVIRALLE---DGDVNLA------------------------KKIIKNTIDNLK--KGNIDKNDLLI------HTQLTKNIEEYK--STAPHIEV--AKKIK----QR--GDS-V--RV---------------------------------------------------------------------------------------------------------GDVISY---IIV----------------------------------KGSR-SIS------------------------ERAELLEYA-------------------------------GDYDINYYID----------------NQVLP--PVIRIMES----------------------------------------------------------------------------------------------L-------------GISE-----------------------------------------------DELK------NSGK------------------QFKLDQFM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Methanopyrus---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLRTV----WVDYAR---K--------------G--------------EPD---VILVGRRE-DG------NPAALV------VKG--------FRPYFY----AEVEDGF--------------------------------DPSEVERL---------------------------SGVVEVEEVLLEH----P-YGG--------DRVEL-L---RIVA-TY---PKVVPK-----LREQVKKL---------------------------DGVKEVYEADIPFVRRAAVDLN-------LPPAS-----------------------------------------------------------------------------------------------------------------------------------------EVD-VSDLDTG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SWSGLPAYFADVEDARE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LDHRP------------------------------------------------------------------------------------------------------------------------------------------------------------------YPIEDLVVAS----------------------------------------------------------------------------------------------------------------------------FDLEVL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AEPGTTI---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KGASGP---------------------------------------------------------------------------------------------------------------------------------------------------------IIAISFAYSTPDGE-----------------------RRNYVITWK---GEDESFEVDGVETE----------------------------------VIVCRSEAAALRRF-----------------FDEFR-RVDPD----------------------VVFTYNGDEFDLPYLQHR------------------------------------------------------------------------------------------------------------------------AGKLGIDVSPLA---------------------------------------------------------------------RPAGKRGIILKH-GGGR---YA-------------SDIFGRAHV--D-LYHTA-RKNLKL-----E--RFTL---------EEAVKDV-L----------------------GVE---------------------------------------------------------------------------------------------------KEEMELAD--INEAWKRG--------------------NLDELMRYSAEDAHYTLEL----GLE----------------------------LAQVELEL-SYLTRLPLPDATRFSFGQLAEWRAIYK--------------------------ARQEDIL----VP----------------NKPTRDE------------------------YKRRRRKA------------------------------------------YKGAIVFEPE-IGLH-----------------------------------------------------------------EN--VVCVDFASLYPNVM-----VAHNISPDT------------------------------------------F----DC--DCCPRVTV-----EEVDDPTDATVA-----------------------------------------------------------------------------------------------------------------------PDVGH---KFCK-------------------RRKG--FFPRLVEGLIERRRELK-----
RRLRKL-----------------DTESHPHE-AKILDVRQQAYKVLANSY--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YGYMGW-ANARWFCRECAESVTAWGRYYISEV-RRIAEE------------------------------------------------------------------------------------KYG--L-KVVYGD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TDSLFVK----------------------LPD-ADLEET---IERVKEFLKEVNG------RLP-------------VELELEDAY-KRILF-------VT-KKKYA-------GYTEDGK--------IVTKGLEVVRRDWAPIARETQRRVLKRILA---DNDPEAA------------------------LKEIHEVLERLK--SGDVDIDELAV------TSQLTKKPSEYV--QKGPHVRA--ALRLA----RHL-GVE-P--EP---------------------------------------------------------------------------------------------------------GTIVRY---VIV----------------------------------RGPG-SVS------------------------DKAYPVELVREEG---------------------------KEPDVDYYIE----------------HQILP--AVERIMRA---------------------------------------------------------------------------------------------------------------------------------------------------------------IGYSRGQIVGETAS------------------QKTLDQFFG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Archaeoglobus-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MERV----------------EGWLI----DADYET---I--------------GG-------------KAV---VRLWCKDD-
QG------IFVAYD-------YN--------FDPYFY--------------------------------------------VIGVDEDILKNAA-----------------TSTRREVIKLK--SFEKAQLKT-LG---------REVEG-----YIVYAHH---PQHVPK-----LRDYLSQF------------------------------GDVREADIPFAYRYLIDKD-------LACMD-----------------------------------------------------------------------------------------------------------------------------------------GIA-IEGEKQG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVIRSYKIEKVERIPR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MEFPELKMLV----------------------------------------------------------------------------------------------------------------------------FDCEML-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SSFGMP------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EPEKDP---------------------------------------------------------------------------------------------------------------------------------------------------------IIVISVKTNDDDE------------------------------------------------------------------------------------IILTGDERKIISDF-----------------VKLIK-SYDPD----------------------IIVGYNQDAFDWPYLRKR------------------------------------------------------------------------------------------------------------------------AERWNI---------------------------------------------------------------------------PLDVGRDGSNVV-FRGG-----------------RPKITGRLNV--D-LYDIA-MRISDI-----K--IKKL---------ENVAEFLGT----------------------KIE---------------------------------------------------------------------------------------------------
IADIEAKD--IYRYWSRG--------------------EKEKVLNYARQDAINTYLIAK--E------------------------------LLPMHYEL-SKMIRLPVDDVTRMGRGKQVDWLLLSE--------------------------AKKIGEI----AP----------------NPPEHAE-------------------------------S------------------------------------------YEGAFVLEPE-RGLH-----------------------------------------------------------------EN--VACLDFASMYPSIM-----IAFNISPDT---------------------------------------------------YGCRDDCYEA--------------------------------------------------------------------------------------------------------------------------------------PEVGH---KFRK-------------------SPDG--FFKRILRMLIEKRRELK-----VELKNL-----------------SPE--SSE-YKLLDIKQQTLKVLTNSF--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YGYMGW-NLARWYCHPCAEATTAWGRHFIRTS-AKIAES-------------------------------------------------------------------------------------MG--F-KVLYGD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TDSIFVT----------------------KAG-MTKEDV-------DRLIDKLHE------ELP-------------IQIEVDEYY-SAIFF-------VE-KKRYA-------GLTEDGR--------LVVKGLEVRRGDWCELAKKVQREVIEVILK---EKNPEKA------------------------LSLVKDVILRIK--EGKVSLEEVVI------YKGLTKKPSKYE--SMQAHVKA--ALKAR----E-M-GII-Y--PV---------------------------------------------------------------------------------------------------------SSKIGY---VIV----------------------------------KGSG-NIG------------------------DRAYPIDLIEDFDGENLRIKTKSGIEI-------------KKLDKDYYID----------------NQIIP--SVLRILER---------------------------------------------------------------------------------------------------------------------------------------------------------------FGYTEASLKGSS--------------------QMSLDSFFS-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Pyrobaculum--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MRFWPL----DATYSV---V--------------GG-------------VPE---VRVFGVDG-EG------RRVVLV------DRR--------FRPYFY------------------------------------------AKCDKCDASLAKSYL---------------------SRVAPVE--AVEVVERRF-FG---------RPTIF-L---KVVA-KV---PEDVRK-----LREAALGA---------------------------PGVVDVYEADIRYYMRYMIDKG-------VVPCA-----------------------------------------------------------------------------------------------------------------------------------------WNV-VEAREAG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KLGPLPLYEVVEWAG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VEEGFPP----------------------------------------------------------------------------------------------------------------------------------------------------------------------PLRVLA----------------------------------------------------------------------------------------------------------------------------FDIEVY---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NER----GSP------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DPLRDP-----------------------------------------------------------------------------------------------------
----------------------------------------------------VVMLAVKTS--------------------------DGREEVFEAEG-------------------------------------------------------RDDRRVIRGF-----------------VDFVK-EFDPD----------------------VIVGYNSNGFDWPYLSER------------------------------------------------------------------------------------------------------------------------AKALGVPL-------------------------------------------------------------------------RVDRLGGVPQQS-VYGH---WS---------------VVGRANV--D-LYNIV-DEFPEI-----K--VKTL---------DRVAEYF------------------------GVMKRSE-----------------------------------------------------------------------------------------------RVLIPGHK--VYEYWNDPA-------------------KRPTLMRYVLDDVRSTLGLAE--K------------------------------LLPFLIQL-SSVSGLPLDQVAAASVGNRVEWMLLRY--------------------------AYRMGEV----AP----------------NREEREY------------------------------EP------------------------------------------YKGAIVLEPK-PGLY-----------------------------------------------------------------SD--VLVLDFSSMYPNIM-----MKYNLSPDT---------------------------------------------------YLEPHEPD-----PPEGVVVA---------------------------------------------------------------------------------------------------------------------------PEVGH---RFRK-------------------APTG--FIPAVLKHLVELRRAVR-----EEAKKY-----------------PPD--SPE-YRLLDERQRALKVMANAM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YGYLGW-VGARWYKKEVAESVTAFARAILLDV-VEYAKR-------------------------------------------------------------------------------------LG--I-EVIYGD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TDSLFVK--------------------------KSGAVD--------RLVKYVEE------RHG-------------IEIKVDKDY-ERVLF-------TEAKKRYA-------GLLRDGR--------IDIVGFEVVRGDWCELAKEVQLNVVELILK---SKSVGEARERV--------------------VKYVREVVERLK--AYKFDLDDLII------WKTLDKELDEYK--AYGPHVHA--ALELK----R-R-GYK-V--GK---------------------------------------------------------------------------------------------------------
GTTVGY---VIV----------------------------------RGPG-KVS------------------------ERAMPYIFVDDA----------------------------SKVDVDYYIE----------------KQVIP--AALRIAEV---------------------------------------------------------------------------------------------------------------------------------------------------------------LGVKESDLKTGRV-------------------EKSLLDFLG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Caldivirga--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MEK----------------RVYLV----DITYGL---V--------------GN-------------SPE---IRMFGVDE-NG------EKVVIL------DRG--------FRPYFY----VIPEEGF---------------------------------EDQVARVIGKMQN-----------------------VIKAD--VTERRL----FG---------KPIKV-V---KVTV-TV---PDKVRE-----LRDRVKSI---------------------------QHVKEVLEADIRFYIRYMIDND-------IRPG------------------------------------------------------------------------------------------------------------------------------------------WLM-FSNLKPV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DNKIGGVSNVYLTE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TPPTSLDLGIMP-------------------------------------------------------------------------------------------------------------------------------------------------------------RLNYMA----------------------------------------------------------------------------------------------------------------------------
LDIEVY-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NPRGTP------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DPKRDP---------------------------------------------------------------------------------------------------------------------------------------------------------IIIIALANS--------------------------NGDVKLLT------------------------------------------------------LDNYKHEREMLNDM-----------------MSVIK-EWDPD----------------------VLFGYNSNKFDMPYLVNR------------------------------------------------------------------------------------------------------------------------ADALNVKL-------------------------------------------------------------------------QLSKYGTPPEQS-VYGH---WS---------------IIGRAHI--D-LYNFI-EDMTDV-----K--RKSL---------DYVAEYF------------------------GVMKRSE-----------------------------------------------------------------------------------------------RVNIPGHR--IYQYWDDEG-------------------KRSQLIKYARDDVLSTLGLGKI--------------------------------LLPYAMQL-ASVSGLPLDQVGPASVGSRVEMMIMHE--------------------------AYKMGEL----AP----------------NRVERPY------------------------------ET------------------------------------------YKGAIVLEPK-PGIH-----------------------------------------------------------------YN--IAVLDFSSMYPNIM-----LKYNISPDT---------------------------------------------------LVLDSSEG-----DYYTA------------------------------------------------------------------------------------------------------------------------------PEVGY---RFRK-------------------SPRG--LYASLLQKLIEARREAR-----DEMRNY-----------------PEG--SFE-WVLLNERQRALKIMANAM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YGYCGW-LGARWYIREVAESVTAWGRYLLKTA-MSMAKE-------------------------------------------------------------------------------------RG--L-
TVIYGD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TDSLFVT--------------------------YDKDKV-------ADIISRINEMG--------------------FEVKIDKVY-SKLIF-------TESKKRYI-------GLTADGE--------VDIVGFEAVRGDWSELARNVQERVAELVLR---E-SVDEA------------------------VKYVKSVIDDLR--NYRFTIDDVII------WKTLDKDINEYK--AIQPHVVA--ARRLM----E-K-GYV-V--NK---------------------------------------------------------------------------------------------------------GDTVGF---VIV----------------------------------KDSGDKLT------------------------QRAYPYVFINDV----------------------------KEIDVDYYVE----------------KQVIP--AALRILEV---------------------------------------------------------------------------------------------------------------------------------------------------------------FGVNEAALLGKTGK--------------------SILDYFH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Thermofilum--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MVAGEVREL----------------EFWIL----DASYDV---V--------------KG-------------HPV---IYLWGITE-SG------ERIVVA------EKN--------FRPYFY----LVPENAI---------------------------------SDALVERVRTALH--------------------TFKVLSVN--AIERKL----FG---------RTLNV-L---KVTI-TD---PRDVPK-----AREVAAKI---------------------------PGIRDVLEADIRFYMRYMVDTG-------ISPSS-----------------------------------------------------------------------------------------------------------------------------------------WV--LAKVRSA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PVPNGWRVDEFFEL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VEAPRSLDKKSTP---------------------------------------------------------------------------------------------------------------------------------------------------------------RLKTYA----------------------------------------------------------------------------------------------------------------------------FDIECY-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NRYGEP------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DPERDP---------------------------------------------------------------------------------------------------------------------------------------------------------VLVISRT----------------------------GEDGTVIFSQD-----------------------------------------------------EGSSEKKLLEEF-----------------VNDLV-QYDPD----------------------VILGYNSNRFDWPYLLQR------------------------------------------------------------------------------------------------------------------------ARVNGVKL-------------------------------------------------------------------------SIGRNLGEPSQS-VYGH---FS---------------VVGRANV--D-LYDYA-SELQEV-----K--VKTL---------ENVSEF--L----------------------GVMKKSE-----------------------------------------------------------------------------------------------RVLIDTNK--VYEYW-DS-----------KD-------KRSLLLRYAGDDARSTYLLGQ--V------------------------------VLPFGIQL-SSLVGLPLDQVFAASVGNRVEWFLIRQ--------------------------AFVFNEL----VP----------------NSRERGE------------------------------ET------------------------------------------YKGAIVLKPK-PGVH-----------------------------------------------------------------KK--IAVLDFSSMYPNIM-----IKYNISPDT---------------------------------------------------YVPPEEHV-----DPSEVWVA------------------------------------------------------------------------------------------------
---------------------------PEVGH---RFRK-------------------HPPG--FYRKVLESLLEARRRLR-----EKMKTL-----------------DPR--SEE-YRIYDERQKAIKVITNAT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YGYSGW-SMARWYKREVAEATTAWGRELIKAT-IKKAQS-------------------------------------------------------------------------------------LG--L-SIIYGD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TDSIFVQ--------------------------FDEEKI-------GRLVEYVEK------ELG-------------FEIKLDKVY-EKVFF-------TESKKKYC-------GLLADGR--------VDLVGFEAVRGDWAEISKEIQERVVEIVLK---EEDPWKA------------------------VDFVRKTITELS--EGRIPLEKLVI------WKTLSKDLDEYE--VDAPHVVV--ARELK----R-L-GYR-V--GK---------------------------------------------------------------------------------------------------------GAKIGY---IVV----------------------------------KGAG-KVS------------------------EKAKPLISVKSP----------------------------DEVDTDYYVK----------------RQIVP--AALRILEY---------------------------------------------------------------------------------------------------------------------------------------------------------------FGVKEEHFSTGRR-------------------QATLSDFF--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Ignicoccus--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
------------------------------------------------------------------------------------------------------------MKFYVL----DVSYEL---E--------------GN-------------KPV---ILIWALDE-NE------RRVLLK------DKR--------FRPYFY----VLLKEN--------------------------------ADLERLKRKLSLLSK-------------------PKSPIISLE--VLKKKL----IG---------REKTV-I---KVTT-VI---PESVRE-----YREEVKRL---------------------------EEVADVLEADIRFSMRYIIDTG-------LRPCG-----------------------------------------------------------------------------------------------------------------------------------------WAE-FEVKELG---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PEKSYRVETVYEVL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NGPEALNIDVKP----------------------------------------------------------------------------------------------------------------------------------------------------------------------KLKTLA----------------------------------------------------------------------------------------------------------------------------FDIEVY-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NKSGTP------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RPERDP---------------------------------------------------------------------------------------------------------------------------------------------------------IISIALASEGS-------------------------------VVSK---------------------------------------------------LSQDKNDKDLIVWF-----------------KKEML-ERDPD----------------------VVVGYNSNSFDWPYLIER------------------------------------------------------------------------------------------------------------------------SKVVGVRLD------------------------------------------------------------------------VGRKVGVIPTTG-AYGH---VS---------------VPGRLNV--D-VYDFA-KEVYEV-----K--VKTL---------ENVADY--F----------------------
NVMKKDE-----------------------------------------------------------------------------------------------RPLIPHHL--IYQYWEDP-----------Q--------KRDVLRKYNEADALSTLMLAE--L------------------------------FIPFGEQL-SYLTGLPLDQVMAASVGYRVEWYLMRV--------------------------AFVTNEL----VP----------------NRVERKV------------------------------AS------------------------------------------YKGAIVLRPL-KGVH-----------------------------------------------------------------EN--VAVLDFSSMYPNIM-----IKYNVGPDT---------------------------------------------------LVRPGEKV-----SPDEVYV----------------------------------------------------------------------------------------------------------------------------SPAGY---MFKK-------------------RPDA--FFKRSLVTLLNLRKEIK-----ERMKSL-----------------SPE--DPL-YKLLDNRQKAVKVLANAH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YGYMGW-PHARWYCRECAEAVTSWGRELILKA-IQMARE-------------------------------------------------------------------------------------LG--L-KVIYGD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TDSLFVI--------------------------YDKEKV-------EKLIERIEK------ELG-------------FEIKIDKIY-KKLFF-------TEAKKRYA-------GILEDGR--------IDVVGFEAVRGDWAEVAKEVQEKIIEIVLK---EGDVNKA------------------------VEYVNSIIEKLR--RGEVPIEKLVI------WKTLEKSLDEYK--SEPPHVAA--AKRAI----ER--GYE-V--KK---------------------------------------------------------------------------------------------------------GDKVGY---VIV----------------------------------KGVG-KLS------------------------SRAWPWFLVQK-----------------------------EMIDYNYYID----------------HQVIP--AAMRILGY---------------------------------------------------------------------------------------------------------------------------------------------------------------FGITEARLKGR---------------------KDGLWKFINK------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Staphylothermus----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSEKINL----------------EFYFL----DNSYEV---I--------------GN-------------EPH---IIIWGITR-DG------RRVLLR------DRR--------FRPYFY----AILKDKV--------------------------------NIEDLARKIRTYSD-------------------PKSPIIGVE--PVEKK---Y-FG---------RKVSA-L---KIIT-MI---PEYVRK-----YREKIKSL---------------------------PEVLEVVEADIRFSIRYIIDHD-------LRPCG-----------------------------------------------------------------------------------------------------------------------------------------WHV-AEVVEVP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KKPIYRVDAEYEII--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GDIKPLEQTLQP---------------------------------------------------------------------------------------------------------------------------------------------------------------DLRIIA----------------------------------------------------------------------------------------------------------------------------FDIEVY---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NKS----GTP------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RPQTDP---------------------------------------------------------------------------------------------------------------------------------------------------------IIIIGIMNN--------------------------
NGDIKQFLANK-------------------------------------------------------YDDKISVEEF-----------------VNYVK-TFDPD----------------------IIVGYNTDGFDWPYLIER------------------------------------------------------------------------------------------------------------------------SKYIGVKLD------------------------------------------------------------------------VTRRVGATPRTS-TYGH---IS---------------VPGRLNT--D-LYHFA-EEIPEV-----K--VKSL---------ENVAEY--L----------------------GVMKKSE-----------------------------------------------------------------------------------------------RVIIEYID--IPKYWDDE-----------K--------LRPKLLQYNIDDVKSTYGLAE--K------------------------------FLPFAMQL-SNITGLPLDQVGAASVGFRLEWYLMRE--------------------------AFRYGEL----VP----------------NRVERAA------------------------------ES------------------------------------------YRGAVVLKPV-KGVH-----------------------------------------------------------------EN--IAVLDFSSMYPNIM-----IKYNVGPDT----------------------------------------------------IVRNEKC-----NPDKHNIA---------------------------------------------------------------------------------------------------------------------------PEVGH---CFRK-------------------EPPG--FFKRVLETLLRLRKQIK-----SEMKKY-----------------PPT--SYE-YRLLDERQKAVKVLANAT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YGYMGW-IHARWYCRECAEAVTAWGRQTIKSA-IELARK-------------------------------------------------------------------------------------LG--L-KVIYGD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TDSLFVT--------------------------YDKDKV-------EKLIELIQT------KLG-------------FEIKIDKIY-KRVFF-------TEAKKRYA-------GLLEDGR--------IDIVGFEAVRGDWAEIAKEVQEKVTEILLK---ENSIDKA------------------------IEYVRQVIADLK--AGKIPLDKLII------WKTLSKRIEEYS--VDAPHVVA--AKKLI----K-A-GIK-V--ST---------------------------------------------------------------------------------------------------------NDKIGY---VIL----------------------------------KGGG-KIS------------------------SRAEPYIFVKDP----------------------------KLIDTEYYVD----------------HQIVP--AALRILNY---------------------------------------------------------------------------------------------------
------------------------------------------------------------FGVTETQLKRAAASAG----------------QKSLFDFFGGKK----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Hyperthermus------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAEEI----------------EFVLL----DSSYEI---V--------------GK-------------EPV---IVLWGVTL-SG------ERVVLL------DRR--------FRPYFY----ALIKRGFE------------------------------ENATAIAAAIRRLSK-------------------GSSPIIALE--VVDKKY----FG---------RPRKA-V---RVTT-VI---PESVRE-----YREAVKKI---------------------------DGVEDALEADIRFAMRYIIDKR-------LYPFM-----------------------------------------------------------------------------------------------------------------------------------------VYR-VPVEDVG---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KNPGYRVDKVFYVT-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GEPQRITDITRIDMP---------------------------------------------------------------------------------------------------------------------------------------------------------------DLRLTA----------------------------------------------------------------------------------------------------------------------------FDIEVY------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NKSGSP------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NPNRDP---------------------------------------------------------------------------------------------------------------------------------------------------------VIIIAVKSS--------------------------NGDEKLFEADG-------------------------------------------------------YDDRKAIRGF-----------------VDYIK-SFDPD----------------------IIVGYNSNGFDWPYLMQR------------------------------------------------------------------------------------------------------------------------ARKVGVRLD------------------------------------------------------------------------VTRRVGAEPTTS-VYGH---VS---------------VPGRLNV--D-LYHYA-EEIHEV-----K--VKTL---------EEVAEY--L----------------------GVMKKSE-----------------------------------------------------------------------------------------------RVLIHWWE--IPRYWEDP-----------E--------KRPILEQYARDDVRATYGLAE--K------------------------------MLPFAIQL-STVTGIPLDQVGVMGVGFRLEWYLIRA--------------------------AYEMNEL----VP----------------NRVERHE------------------------------ES------------------------------------------YRGAVVLKPL-KGVH-----------------------------------------------------------------EN--VVVLDFSSMYPNIM-----IKYNVGPDT---------------------------------------------------IVDDPAEC------EKYGGCYVA-------------------------------------------------------------------------------------------------------------------------PEVGH---RFRK-------------------QPPG--FFKTVLENLLRLRKQVR-----EKMKEL-----------------PPE--SPE-YRLYDERQRALKVLANAS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YGYMGW-SGARWYCKRCAEAVTAWGRSLILSA-IEYARK-------------------------------------------------------------------------------------LG--L-KVIYGD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TDSLFVT--------------------------YDPEKV-------KKLIDYVVN------VLG-------------FEIKIDKIY-
RRVFF-------TEAKKRYV-------GLLEDGR--------IDIVGFEAVRGDWCELAKEVQSTVAEIVLK---TGKIDEA------------------------IRYIRDVIKKLR--EGEIPVEKLII------WKTLSKRLEEYE--HEAPHVVA--ARRMK------EAGYD-V--SP---------------------------------------------------------------------------------------------------------GDKIGY---VIV----------------------------------RGAG-RIS------------------------SRAYPYFMVKP-----------------------------SDIDVDYYID----------------HQIVP--AVLRILSY----------------------------------------------------------------------------------------------F---------------GV-----------------------------------------------TEKQLKAASTGHRT------------------LFDFMRGKRG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Halobacterium--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MGNTELSEFMHESDGADDPGEDAIQEEAAVVAGDADPVVNEVLTAEADALPDATGEV----------------ELMVT----QVDYTI---E--------------GSGDRE---------RPV---LHVFGRTT-DD------EAEHVR------VHG--------FRPYFY----APTAT---------------------------------LSEDDLTDDVITGTE----------------------------------------DGYESI-----RGEAL-----TKIFGRT---PRDVGN-----IRDA----------------------------------FDHYEADILFPNRLLIDKD-------ITDGV--------------------------------------------------------------------------------------------------------------------------------------------RVPARRAD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DGALYVHHDEIAACE------------------------------------------------------------------------------------
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VAADLRVNT----------------------------------------------------------------------------------------------------------------------------FDIEVN-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DRNGFP------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EDGEEP---------------------------------------------------------------------------------------------------------------------------------------------------------VVCLTSHDSYR------------------------DEYVAWLYAAP---DATVDAPTAVPGYDPLTDDADID-------------------------VRVFDTEEAMHDAF-----------------LSYIE-DTNPD----------------------VLTGWNFDDFDAPYLIDR------------------------------------------------------------------------------------------------------------------------LDELDPRTDHDLDS-------------------------------------------------------------------DRLSRVSEVWTS-GWGG---PN---------------VKGRVVF--DLLYAYQRTKYSEL-----D--SYRL---------DAVGEQE-L----------------------GVG---------------------------------------------------------------------------------------------------KERYPGD---IGDLWED---------------------DPERLLEYNLRDVELCVEIDR--KQS----------------------------IVAFWDEA-RKLVGCKLEDATTPGDA--VDMYVLHK--------------------------AFG-NFV----LP----------------SKGQQDA------------------------------EE------------------------------------------FEGGAVFDPI-TGVR-----------------------------------------------------------------EN--VSVLDLKSLYPMSM-----VTINASPET---------------------------------------------------KV-----------DPEEFDGDTYR------------------------------------------------------------------------------------------------------------------------TPTGV---HFRK-------------------EPDG--IIREMVDELLTEREEKK-----ARRDDH-----------------EPD--SED-YERYDRQQAAVKVIMNSL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YGVFGW-DRFRLYDRAMSAGVTSTNREVIDFT-EQAAEE-------------------------------------------------------------------------------------FG--Y-EVAYGD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TDSVMLE---------------------LGDD-MTKAEA---IAESFDIEDHINA------AYDEFAREQLHADDHRFQIEFEKLY-RRFFQ-------AGKKKRYA-------GHIVWKEG--KDVDDVDITGFEYQRSDIAPITKRVQKEVIDLVVR---EGDVDAV------------------------EEYVHGVIEEFQ--EGDADLDDIGI------PGGIGKRLDNYE--TDTAQVRG--AKYAN----LLL-GTN-F--DR---------------------------------------------------------------------------------------------------------GSKPKR---LYL----------------------------------AKVH-PDFWGHVEDEQGIDTSTSDRYREFRRDPDVICYEYADQIPDT-------------------------FVVDYDKMLD----------------KTLKG--PIERILEA----------------------------------------------------------------------------------------------L-------------DLSW-----------------------------------------------DEVK------SGQT------------------QTGLGQFT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Halobacterium_NRC1--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MGNTELSEFMHESDGADDPGEDAIQEEAAVVAGDADPVVNEVLTAEADALPDATGEV----------------ELMVT----QVDYTI---E--------------GSGDRE---------RPV---LHVFGRTT-DD------EAEHVR------VHG--------FRPYFY----APTAT---------------------------------LSEDDLTDDVITGTE----------------------------------------DGYESI-----RGEAL-----TKIFGRT---
PRDVGN-----IRDA----------------------------------FDHYEADILFPNRLLIDKD-------ITDGV--------------------------------------------------------------------------------------------------------------------------------------------RVPARRAD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DGALYVHHDEIAACE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VAADLRVNT----------------------------------------------------------------------------------------------------------------------------FDIEVN-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DRNGFP------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EDGEEP---------------------------------------------------------------------------------------------------------------------------------------------------------VVCLTSHDSYR------------------------DEYVAWLYAAP---DATVDAPTAVPGYDPLTDDADID-------------------------VRVFDTEEAMHDAF-----------------LSYIE-DTNPD----------------------VLTGWNFDDFDAPYLIDR------------------------------------------------------------------------------------------------------------------------LDELDPRTDHDLDS-------------------------------------------------------------------DRLSRVSEVWTS-GWGG---PN---------------VKGRVVF--DLLYAYQRTKYSEL-----D--SYRL---------DAVGEQE-L----------------------GVG---------------------------------------------------------------------------------------------------KERYPGD---IGDLWED---------------------DPERLLEYNLRDVELCVEIDR--KQS----------------------------IVAFWDEA-RKLVGCKLEDATTPGDA--VDMYVLHK--------------------------AFG-NFV----LP----------------
SKGQQDA------------------------------EE------------------------------------------FEGGAVFDPI-TGVR-----------------------------------------------------------------EN--VSVLDLKSLYPMSM-----VTINASPET---------------------------------------------------KV-----------DPEEFDGDTYR------------------------------------------------------------------------------------------------------------------------TPTGV---HFRK-------------------EPDG--IIREMVDELLTEREEKK-----ARRDDH-----------------EPD--SED-YERYDRQQAAVKVIMNSL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YGVFGW-DRFRLYDRAMSAGVTSTNREVIDFT-EQAAEE-------------------------------------------------------------------------------------FG--Y-EVAYGD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TDSVMLE---------------------LGDD-MTKAEA---IAESFDIEDHINA------AYDEFAREQLHADDHRFQIEFEKLY-RRFFQ-------AGKKKRYA-------GHIVWKEG--KDVDDVDITGFEYQRSDIAPITKRVQKEVIDLVVR---EGDVDAV------------------------EEYVHGVIEEFQ--EGDADLDDIGI------PGGIGKRLDNYE--TDTAQVRG--AKYAN----LLL-GTN-F--DR---------------------------------------------------------------------------------------------------------GSKPKR---LYL----------------------------------AKVH-PDFWGHVEDEQGIDTSTSDRYREFRRDPDVICYEYADQIPDT-------------------------FVVDYDKMLD----------------KTLKG--PIERILEA----------------------------------------------------------------------------------------------L-------------DLSW-----------------------------------------------DEVK------SGQT------------------QTGLGQFT---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
-----------Methanospirillum-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MISPGEQQSPAEKDQN----------------KRILL----SICQVE---Y--------------STAAD----------GPI---IHIFGRTE-TG------DFKEIQ------VTG--------FFPYLY----------------------------------------------ILASQVTRNHP---------------------DQVIKIDPTPYTSI----------------HGEEL-R---RLYT-RR---PTDVRE---------------------------------------VRGNYTHFEADIPFATRYLIDAG-------ITGGI-------------------------------------------------------------------------------------------------------------------------------------------S-VPAGASI----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VPYTDVKPAEVHA-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PTRYCL----------------------------------------------------------------------------------------------------------------------------LDIECE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DDKG---GLP------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NPDRDR---------------------------------------------------------------------------------------------------------------------------------------------------------IICITAWDSFS------------------------DHYTTFLLQNS---ERSINEENLCRNTLHNGCFRGDIHT-----------------------IRVFDDEKSLLTGF-----------------SSYIR-ENNPD----------------------
ILSGWNFTDFDLPFIFGR------------------------------------------------------------------------------------------------------------------------IRALNL---------------------------------------------------------------------------PPDSMARLPGMS-ERSG--------------------VRGRVDF--DLLAGYKKMQSSKL-----D--SYRL---------DAVGERE-V----------------------GD----------------------------------------------------------------------------------------------------VKAFHYQPGMTARMWNE---------------------APHELVEYNFKDVELCVKINQ--KNN----------------------------IIEFYQEI-ARYVGCPLDRTL--NSSNVIDIYILRK---------------------------AHGKFI----LP----------------SKGYSPG------------------------------DE------------------------------------------FEGATVFEPS-SGIR-----------------------------------------------------------------EN--VVVLDLKSLYPMAM-----MTINASPET---------------------------------------------------KDPNGDLI----------------------------------------------------------------------------------------------------------------------------------------APNGI---KFRS-------------------KPDG--LTRSIISELLQERDLKK-----NKRNEY-----------------PFG--SQE-YQLYDMQQNVIKVIMNTY--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YGVSGY-SRFRLYDREIGSAVTSVGRAIIEHT-RNTIEN-------------------------------------------------------------------------------------MG--Y-SVIYGD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TDSCMIQ----------------------IPA-TSLEET---ITKAREIEAVLNE------SYNTFAREVLHAEKHYFSIKFEKVY-RRFFQ-------GGKKKRYA-------GNLIWKEG--KSVDETDMVGFEAKRSDSPLLTRKVMKEVMNKILQ---GADLPEI------------------------KKYLGDIIKTYR--SGGYSLDEIGI------PGGLGKELKDYG--TDDAHVRG--ATYSN----TYL-GTN-F--GK---------------------------------------------------------------------------------------------------------GSKPKR---IYI----------------------------------KSVN-GGY----------------------PKTDVLCFEYGDQVPDA-------------------------FVPDLELMLE----------------KTIKS--PISRILEP----------------------------------------------------------------------------------------------I-------------GWSW-----------------------------------------------SDVDPT--------------------------RTTLSDFF--------------------------------------------------------------------------------------------------
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Halorubrum_phageHF2--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MKEIYITNT-------------------------ELVYED---Y-----------------------------TPK---AKLFGRTE-AG------KSDSVT------VEN--------FPAYFY----VPAEERG--------------------------------RVDPFDNDYLEGYE------------------------------DTDKTGLV-------------NDEEL-V---KVIV-NN---PKKMGE-----VASFFSKS---------------------------------WEADVDYTDRLRIDLG-------IKTGV--------------------------------------------------------------------------------------------------------------------------------------------RVPSSRVT-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PDEIEPIEMDA------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PPRVLT----------------------------------------------------------------------------------------------------------------------------FDIETD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
DRGEGFP------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EYGQAR---------------------------------------------------------------------------------------------------------------------------------------------------------ILSIVAHDNYT------------------------DEYVGFIDLDGHGLGERFPDADLDAVSHPSDLGLDKLSK-----------------------LNFEPDERKMLTEF-----------------AKYVN-EKDSD----------------------LVVGWNSNGFDTPFVIER------------------------------------------------------------------------------------------------------------------------MKERGVN--------------------------------------------------------------------------ADRLSRTGNTYT-GYGG---PT---------------IQGRTCY--DLMDAWKDTKFTKV--------SGSL---------DNAAQME-L----------------------EDA---------------------------------------------------------------------------------------------------KIEHTDKG--FYELYSE---------------------NTQKFLNYNTKDVSLTVGVND--AAN----------------------------VLAFKKAL-RDTIGLDFEQTT--ANNEFIEMMIRRK--------------------------LHTEGYA----GP----------------TANPPEE-----------------------------TEK------------------------------------------YDGAYVFPAF-NGLK-----------------------------------------------------------------EN--VVGIDLASLYPNTL-----WMLNASPET---------------------------------------------------KVDPLYVEEHDDGLYAVLEEGGDLVPVAK-------------------------------------------------------------------------------------------------------------------AANDV---YFRL-------------------DYDG--VFRELVDEALRLKEHA------GEMKK------------------DDSLSAEE-KSKWAEEYSVRKTIVNSI--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YGVLGW-ARFFLYDDDIAAAVTLTGQAVIKRT-AKYVDE-------------------------------------------------------------------------------------ES--IANVAYGD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TDSNYIE----------------------FDSSMNQREC---LEAADAITDKLNNEV----YVDLAAEYGMPTDPCRFDIEIEMYA-SHFFM-------SGQKKFYAYTKVWDEGMDYDATLK-DGKGKLSISGYPCKKANTAQLTKEVQRETLETIVR---GGESDDI------------------------
RRIIREGAERID--ASNPDFDLIGI------PGGLGKELEDYSWTDGTPKGASPRAAYYG----NKFINDCNF--GK---------------------------------------------------------------------------------------------------------GNTVKR---VYL----------------------------------KHTTLGED-----------------TLDVIGYERGAQLDDLSDQ----------------------------LTVDVKRMQD----------------TLVRN--PMVDILDA----------------------------------------------------------------------------------------------V-----------------------------------------------------------------DIDVDAAIEGQS-------------------QTGLAAFC--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Aeropyrum--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAGPAKPKKPEPPPTLHREREPESKYQNTLPETTGKEPASMSLRRNQPSSKHEEYNSESGDVRGLTLEPSPQSELSDDDVILELVREPWVESV----------------RGYLL----DVRYDG---S--------------LG-------------KAV---LMLYDPSS-GS------LVKWAD------RTG--------HKPYFL----TDARPED-------------------------------LRAAGVDVSHDESFH-------------------QYDLVEKFH--PIDR-----------------KLVKL-T---KIVV-SD---PLAVRR-----LREKVSSA-----------------------------GFSVWEADIKYHHNYIFDRQ-------LIPGI-----------------------------------------------------------------------------------------------------------------------------------------LYE-VGGVRIV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HTLPLEMDDATRIVD-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EIFREEPREVRERAREWLRIFE-------------------------------------------------------------------------
-------------------------------------------------------------------------------APPPKLPLIA----------------------------------------------------------------------------------------------------------------------------FDIEVY-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SPIATRLP------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DPSTAP---------------------------------------------------------------------------------------------------------------------------------------------------------YPVISAATADS------------------------SGRSRVVLLYP---GGSRFYEGALPEGTE---------------------------------VEIYDSERAMLLDL-----------------VRILQ-RYP------------------------LVVSFNGDNFDLPYIARR------------------------------------------------------------------------------------------------------------------------LEVLGV---------------------------------------------------------------------------PREFAPIELKQD----------------------YATFRRSLHI--D-LHKLFGIRALQVYAFGNKYRELSL---------ESISRAL-L----------------------GKG---------------------------------------------------------------------------------------------------KVELKAP---VSEL------------------------NLNKLIEYNLQDARLTLELLTFSNNL----------------------------VFNLIIMV-MRTSKLGIEDITRSQISNWIRGLMYWE--------------------------HRRRGWL----VP----------------SRGEIEK----------------LSSAGARVGAIIKDKK------------------------------------------YRGAIVLDPP-VGIF-----------------------------------------------------------------FR--VLVLDFASLYPSLI-----KQWNLSYET-----------------------------------------------VNNPNCRDTIEV----------------------------------------------------------------------------------------------------------------------------------------PEVGH---RVCR-------------------EFKG--ISNEIVGMLRDFRVRLY-----KKKSK------------------DKSLREEE-RLWYDVVQSAMKVYINAS----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
----------------------------------------------YGVFGS-EKFSLYSLPVAESVTALGRAVLRGT-LEKSRE-------------------------------------------------------------------------------------LN--L-HIVYGD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TDSLFIW--------------------------DPPKDV------LNDLVDYVER------TYG-------------LELELDKVF-RAILF-------SGLKKNYL-------GITEEGD--------IVIKGMVAKKSNTPEFIKDEFSKAVKILSRLEKPEDVEAILAEL--------------------RDHINTVYNNVK--KKVYTLDQFAI------KVMLSKNPREYDK-NTPQHVKA--AMLLQ-----RL-GLT-L--SR---------------------------------------------------------------------------------------------------------GDIVYY---VKT----------------------------------RDKL-GVK-----------------------------PVQLARL----------------------------SDVDPGKYVE-----------------HVKT--AFEQMLMA----------------------------------------------------------------------------------------------F-------------GISW-----------------------------------------------DDISG---------------------------VRKLDRLLFD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------S-----------------------------------------------------------------------------------------------------Sulfolobus----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MTKQLTLFDIPSSKPAKSEQNTQQSQQSAPVEEKKVVRREWLEEAQENK----------------IYFLL----QVDYDG---K--------------KG-------------KAV---CKLFDKET-QK------IYALYD------NTG--------HKPYFL----VDLEP---------------------------------DKVGKIPKIVRDPSF---------------------DHIETVS----KIDPYTW------------NKFKL-T---KIVV-RD---PLAVRR-----LRNDVPKA---------------------------------YEAHIKYFNNYMYDIG-------LIPGM-------------------------------------------------------------------------------------------------------
----------------------------------PYV-VKNGKLE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SVYLSLDEKDVEEIKK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AFADSDEMTRQMAVDWLPIFE--------------------------------------------------------------------------------------------------------------------------------------------------------TEIPKIKRVA----------------------------------------------------------------------------------------------------------------------------IDIEVY-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TPVKGRIP------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DSQKAE---------------------------------------------------------------------------------------------------------------------------------------------------------FPIISIALAGS------------------------DGLKKVLVLNRNDVNEGSVKLDGIS-------------------------------------VERFNTEYELLGRF-----------------FDILL-EYP------------------------IVLTFNGDDFDLPYIYFR------------------------------------------------------------------------------------------------------------------------ALKLGY---------------------------------------------------------------------------FPEEIPIDVAGK-DEAK---YL-----------------AGLHI--D-LYKFFFNKAVRNYAFEGKYNEYNL---------DAVAKAL-L----------------------GTS---------------------------------------------------------------------------------------------------KVKVDT----LISFL-----------------------DVEKLIEYNFRDAEITLQLTTFNNDL----------------------------TMKLIVLF-SRISRLGIEELTRTEISTWVKNLYYWE--------------------------HRKRNWL----IP----------------LKEEILA-----------------KSSNIRTSALIKGKG------------------------------------------YKGAVVIDPP-AGIF-----------------------------------------------------------------FN--
ITVLDFASLYPSII-----RTWNLSYET---------------------------------------------------VDIQQCKK-----PYEVKDET---------------------------------------------------------------------------------------------------------------------------GEVLH---IVCM-------------------DRPG--ITAVITGLLRDFRVKIY-----KKKAK------------------NPNNSEEQ-KLLYDVVQRAMKVFINAT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YGVFGA-ETFPLYAPAVAESVTALGRYVITST-VKKARE-------------------------------------------------------------------------------------EG--L-TVLYGD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TDSLFLL----------------------NPP-KNSLEN---------IIKWVKT------TFN-------------LDLEVDKTY-KFVAF-------SGLKKNYF-------GVYQDGK--------VDIKGMLVKKRNTPEFVKKVFNEVKELMISINSPNDVKEIKRKI--------------------VDVVKGSYEKLK--NKGYNLDELAF------KVMLSKPLDAYKK-NTPQHVKA--ALQLR----PFGVNVL-P-------------------------------------------------------------------------------------------------------------RDIIYY---VKV----------------------------------RSKD-GVK-----------------------------PVQLAKV----------------------------TEIDAEKYLE-----------------ALRS--TFEQILRA----------------------------------------------------------------------------------------------F-------------GVSW-----------------------------------------------DEIAA---------------------------TMSIDSFFSY----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PSKGNS----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
----------Caldiarchaeum-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAFMAE----------------RYFLL----GVGYDG---Q--------------EK-------------KAF---LKLLNLST-NT------VEIHMD------STG--------HKPYCL--------------------------------------------TDRPIDELEKNQA--------------------LREAGATAFIKVTKYDSIAD-----------RMREM-----TLIQATD---PLAVGG-----SKKSIREL------------------------------VTAWEADIPYHLNYVYDMR-------LTPSM-----------------------------------------------------------------------------------------------------------------------------------------IYE-KKNGMLT---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PVFGEKSKVENILQ-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QFFPDLPAEEREEMEKWLRMLE--------------------------------------------------------------------------------------------------------------------------------------------------------SEHPAVDFTG----------------------------------------------------------------------------------------------------------------------------LDIEIL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SDSPTKVPSP------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SNPVDR---------------------------------------------------------------------------------------------------------------------------------------------------------VVAISFSGT--------------------------RGMGKVLVLRR---DGVDMTFNGGEYS-----------------------------------VEVFDDETTLLSRC-----------------FEIMD-SYP------------------------
IVVTFNGDDFDLPYLRNR------------------------------------------------------------------------------------------------------------------------AEKLGI---------------------------------------------------------------------------PKNRIPITLGRE----------------------GASLRRGIHL--D-LYRFFNNKSVQVYAFDNRYREHTL---------DGVAKAL-I----------------------GVG---------------------------------------------------------------------------------------------------KVELTKT---LNEL------------------------SLQELADYSYRDSRLLRDMVEAGDRL----------------------------ILRLMAVI-SRISKMPIEDVCRHGVSGWIKNLLYWE--------------------------LRGRNWL----IP----------------RKDELIT-----------------AKGGTTTKAIIEGKK------------------------------------------YRGALVVEPV-PGIH-----------------------------------------------------------------FN--VTVLDFASLYPSIL-----KEYNLSFET---------------------------------------------------INCSHEKC-----RTNNI------------------------------------------------------------------------------------------------------------------------------PETTH---WVCR-------------------EKRG--VQSSIIGVIRDIRVRWY-----KPMAS------------------NKSLDPVT-RSWYEVVQRALKVFLNAS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YGVLGF-EEFPLYCPPLAESTTAIGRYVFSSA-VEKAKS-------------------------------------------------------------------------------------LG--V-TVVYGD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TDSIFLK--------------------------AEKQEL------VHELIRWARE------KFR-------------LDLEFDKVY-RYVVF-------SKRKKNYL-------GVTDRGV--------VDVKGLTGKKRNIPVFIKEAFDDMLKQLAEVKSAEELETVKKNI--------------------RQVIATWYSRLK--NRTFEIDQLAF------RVMMSKTIERYEK-TTPQHVKA--AKKLQ----SLGVKVG-P-------------------------------------------------------------------------------------------------------------GDIISY---VKT----------------------------------KDKD-GVT-----------------------------PLQLAKR----------------------------ENIDVDKYIE-----------------YMRS--TFEQVLDP-------------------------------------------------------------------------------------------------
--------------------------------------------------------------LEIDFDSIIG----------------------LTSLESFM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Cenarchaeum---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VQDAVEIP----------------PSLLV----SATYDS---Q--------------AG-------------AVV---LKFYEPES-QK------IVHWTD------NTG--------HKPYCY--------------------------------------------TRQPPSELGELEG--------------------REDVLGTE--QVMRHDLIAD-----------KDVPV-T---KITV-AD---PLAIGG-----TNSEKSIR----------------------------NIMDTWESDIKYYENYLYDKS-------LVVGR-----------------------------------------------------------------------------------------------------------------------------------------YYS-VSGGKVI--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PHDMPISDEVKLALK---------------------SLLWDKVVDEGM--------------------------------------------------------------------------------------------------------------------------------------------------------------------ADRKEFREFIAGWADLLN--------------------------------------------------------------------------------------------------------------------------------------------------------QPIPRIRRLS----------------------------------------------------------------------------------------------------------------------------FDIEVD-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SEEG---RIP------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DPKISD-------------------------------------------------------------------------------------------------------------------------------------------------------RRVTAVGFAAT--------------------------DGLKQVFVLRS---GAEEGENGVTPGVE----------------------------------VVFYDKEADMIRDA-----------------LSVIG-SYP------------------------FVLTYNGDDFDMPYMLNR------------------------------------------------------------------------------------------------------------------------ARRLGV---------------------------------------------------------------------------SDSDIPLYMMRD----------------------SATLRHGVHL--D-LYRTFSNRSFQLYAFAAKYTDYSL---------NSVTKAM-L----------------------GEG---------------------------------------------------------------------------------------------------KVDYGVK---LGDL------------------------TLYQTANYCYHDARLTLELSTFGNEI----------------------------LMDLLVVT-SRIARMPIDDMSRMGVSQWIRSLLYYE--------------------------HRQRNAL----IP----------------RRDELEG-----------------RSREVSNDAVIKDKK------------------------------------------FRGGLVVEPE-EGIH-----------------------------------------------------------------FD--VTVMDFASLYPSII-----KVRNLSYET---------------------------------------------------VRCVHAEC-----KKNTI------------------------------------------------------------------------------------------------------------------------------PDTNH---WVCT-------------------KNNG--LTSMIIGSLRDLRVNYY-----KSLSK------------------STSITEEQ-RQQYTVISQALKVVLNAS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YGVMGA-EIFPLYFLPAAEATTAVGRYIIMQT-ISHCEQ-------------------------------------------------------------------------------------MG--V-RVLYGD-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------TDSLFIK--------------------------DPEERQ---IHEIVEHAKKEHG----------------------VELEVDKEY-RYVVL-------SNRKKNYF-------GVTRAGK--------VDVKGLTGKKSHTPPFIKELFYSLLDILSGVESEDEFESAKMRI--------------------SKAIAACGKRLE--ERQIPLVDLAF------NVMISKAPSEYVK-TVPQHIRA--ARLLE----NAR-E---V--KK---------------------------------------------------------------------------------------------------------GDIISY---VKV----------------------------------MNKT-GVK-----------------------------PVEMARA----------------------------GEVDTSKYLE-----------------FMES--TLDQLTSS---------------------------------------------------------------------------------------------------------------------------------------------------------------MGLDFDEILGKPK-------------------QTGMEQFFFK------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Nitrosopumilus--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MQVNLPETKKIESMP----------------ASMLV----SATYDN---I--------------SK-------------SAV---LKFYDPES-KK------LFLWKD------ETG--------HKPYCY--------------------------------------------SRLSPDELDFLQE--------------------RDDILEIK--TVRKYDLMKD-----------KEIDM-S---KITV-AD---PLAIGG-----TAGDKSIR----------------------------NVIETWESDIKYYENYLYDRQ-------LIVGK-----------------------------------------------------------------------------------------------------------------------------------------YYE-VVNGELK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
SHDLEISDEVRLALK---------------------SLLWDKVDSESM--------------------------------------------------------------------------------------------------------------------------------------------------------------------VDAEEFKKYISEWADLLN--------------------------------------------------------------------------------------------------------------------------------------------------------QPIPKIKRLS----------------------------------------------------------------------------------------------------------------------------IDIEVE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AEIGRIPDP------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KIAEKK---------------------------------------------------------------------------------------------------------------------------------------------------------VTAIGLKGS--------------------------DGFDQIFVLKT----EGTEEGTNELEQNIKIT------------------------------FYESDKEKEMIQDA-----------------FEIMK-TFP------------------------FVLTYNGDEFDLPYLYNR------------------------------------------------------------------------------------------------------------------------AERLGV---------------------------------------------------------------------------KNSDNPLYMMRD----------------------SATLKEGVHL--D-LYKVLSNRSFQIYAFSQKYTDFSL---------NSVSKAL-L----------------------G-----------------------------------------------------------------------------------------------------KEKIDYGL--EFDEL-----------------------SLYQTANYCYNDALLTYELTSFNKDL----------------------------MMDLLVII-ARIGRMPIDDIARMGVSQWIRSLLYYE--------------------------HRRENCL----IP----------------KREELQR-----------------RSEGVMSDAVIKDKK------------------------------------------YRGGLVVEPK-EGIH-----------------------------------------------------------------FD--VVVMDFASLYPSII-----KVRNLSYET---------------------------------------------------VRCPHEEC-----KKNTI------------------------------------------------------------------------------------------------------------------------------PGTNH---WACT-------------------KKNG--QTSMIIGSLRDLRVNYY-----KSLSK------------------KETLTDDQ-
RQQYTVVSQALKVILNAS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YGVMGA-EIFPLYFLPVAEATTAIGRYTILET-IKKCEE-------------------------------------------------------------------------------------AG--I-EVLYGD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TDSLFIK--------------------------NPTKEQ---IKIVIEQAKKEHG----------------------VDLEIDKTY-RYCVL-------SNRKKNYL-------GVTKDGK--------VDVKGLTGKKSHTPAFIKNLFYELIDVLSRVQTVEDFVKAKQEI--------------------TEKIATCGKKVE--AKEIPLKDLTF------NVMLSKAPSEYVK-TIPQHIRA--AKQLE----SIRE----I--KK---------------------------------------------------------------------------------------------------------GDKISF---IKI----------------------------------LNKP-GVK-----------------------------PVELAKK----------------------------EEIDSKKYME-----------------FMES--TLEQITSS---------------------------------------------------------------------------------------------------------------------------------------------------------------MDLDFDTMLGKPK-------------------QTGLDEFFWS------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Nitrosoarchaeum--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MQVNVKETEKITSMP----------------PSMLV----SAIYDN---I--------------TR-------------TAV---LKFYEPIS-QK------LILWND------ETG--------HKPYCY--------------------------------------------
SRLAPDELDFLQE--------------------RDDILEIK--SVKRHDLIKD-----------EEVNL-S---KITV-AD---PLTIGG-----TTGDKSIR----------------------------NIIETWESDIKYYENYLYDRS-------LIVGK-----------------------------------------------------------------------------------------------------------------------------------------YYE-IIDGKIK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PHDLEISDEVKLALK---------------------SLLWDKVDSENM--------------------------------------------------------------------------------------------------------------------------------------------------------------------VDPKEFKELISDWADLLN--------------------------------------------------------------------------------------------------------------------------------------------------------QPIPRIKRLS----------------------------------------------------------------------------------------------------------------------------VDIEVE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AEIGRIPDP------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KVAEKK---------------------------------------------------------------------------------------------------------------------------------------------------------VTAIGLKGT--------------------------NDFDQIFVLRT----EGTDEGTNELGKNIKIV------------------------------FYDQDKEKEMILDA-----------------FKIIE-EFP------------------------FVVTYNGDEFDLPYLYNR------------------------------------------------------------------------------------------------------------------------AERLGI---------------------------------------------------------------------------KKEENPLYMMKD----------------------SATLKQGVHL--D-LYRTLSNRSFQIYAFSQKYTDFSL---------NSVSKAL-L----------------------N-----------------------------------------------------------------------------------------------------KEKIDYGL--EFDQL-----------------------
SLYQTANYCYNDALLTYELTSFNKDL----------------------------LMDLLVII-SRIGRMPIDDIARMGVSQWIRSLLYYE--------------------------HRQRNAL----IP----------------KREELEK-----------------RSEGVTSDAVIKDKK------------------------------------------YRGGLVIDPK-EGIH-----------------------------------------------------------------FD--VVVMDFASLYPSII-----KVRNISYET---------------------------------------------------VRCSHEEC-----KKNTI------------------------------------------------------------------------------------------------------------------------------PQTNH---WACT-------------------KRNG--ITAIIIGSLRDLRVNYY-----KSLSK------------------KETLTEDQ-RQQYTVVSQALKVILNAS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YGVMGA-EIFPLYFLPAAEATTAIGRFTILET-IKKCEA-------------------------------------------------------------------------------------IG--I-EVLYGD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TDSLFIK--------------------------KPTDQQ---IHTVIEQAKKDHG----------------------VDLEIDKVY-RYCVL-------SNRKKNYL-------GVTKSGT--------VDVKGLTGKKSHTPPFIRNLFYELLDVLSKVQTVADFENAKKEI--------------------TDKIATCAKKVE--SKEIPLKDLTF------NVMISKAPSEYVK-TVPQHIRA--ARLLE-------SIRE-V--KK---------------------------------------------------------------------------------------------------------GDKISY---VKI----------------------------------INKP-GVK-----------------------------PLEMAKK----------------------------EEIDSKKYME-----------------FMES--TLDQITSS---------------------------------------------------------------------------------------------------------------------------------------------------------------MDLDFQTMLGKPK-------------------QTGLDEFFWN----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Megavirus_terra1---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLVFKSQI---------------------------------------------------------------------------------AMREFSNVLARPLK-----------------------------------------------------------------------TEGLTK---------------------------------------EPMLYQRFESNIEPHIRCMHINN-------LSSCG-----------------------------------------------------------------------------------------------------------------------------------------WVT-IDNKNLK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NNSEYSNCDYSYSVQ-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------WKHIKPSSNDDRMA--------------------------------------------------------------------------------------------------------------------------------------------------------------PLKIMG----------------------------------------------------------------------------------------------------------------------------YDIECV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SCDH---NFPQA----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DRETDK----------------------------------------------------------------------------------------------------
-----------------------------------------------------IIQIGITMYRYGSM---------------------ECYEQYILTLK---KCARIKGTN---------------------------------------VECYKTEKGLIRGW-----------------AKKIS-EIRPD----------------------FKGGYNNFGFDDKYIFDR----------------------------------------------------------------------------------------------------------------INRIDREEADRQGISVNELENRFLDEILNIMGKVNNVYLIENEGVNKLTDDSNTRQHEGIRKS--------------------------LTYFEIKNLSSS-ALGD---NE----------LKFFQVPGIISV--D-MMKVI-QRDHRL-----I--GYKL---------DNVSANF-ITQKALRCVE------------TGKNNDDENLDISIYTESTKALEKDSYIQIMVDDGYSSSPLCEGAKYKVIDIDGITETVYDENEKKNVTYSYQAIKTKISQKDTEQLREVLTNKLLRVYWTFAKDDMHHTL--INKYFNEG-----------DPK------KIRQIAKYCIKDCKLVNLLLA--KLE----------------------------IIVNSVGM-AKVCHVPLSYLFLRGQGVKIFSLVSKK--------------------------CREKNFL----IP----------------VLRRNKK-----------------------DNDGDDDNT------------------------------------------YEGATVITPK-PNVY-----------------------------------------------------------------LS-PIGVLDYSSLYPNSM-----RERNLSPECYINDNKYDNLPGYIYHDVTIILKDKKGKIIRNLDGSPKKEHHRFAQELINDKQINTEMKDIFDKINKTMDNNIETILQQTYFTIKNIEDKIKKEKLITDSRIEDISFNDDFSTKKKAKLIETEKIEMKNRLKIYLEIDEKIKEISIKKKLSIDNIDKSLDADQKSKEIGKIEKTYNENIKNVLEKYIISKEEREEMITME---REKATKSMNDEKSKVYNIVDGKMVRYG--ILPEILTELLNKRKETN-----GRLAV------------------EKD--SFV-KAILNALQLAFKVTANSL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YGQTGA-PTSPIFFIAIAASTTAIGRERLHYA-RKMVED-----------------------------------------------------------------------------------NFPG--S-EVIYGDSVTGDTPIMI-KDKNNNINIVTIKELGEKWKPYDIFKSHEINSNRKYKQQADF--NGEVWTSNGWAKIKRVIRHKTVKKLYRVLTNTGCIDVTEDHSLLDTNKNIIKPIDCKIGTELLHGFPEINNNH-----------------------------------------NKLSLE---IYKEL--DITSELFDCMIESNKKW--NNEKMK---AC---------------------------------FIGSEYRK------QNKNISNEILNC--SKKIKKYFLLGYLG-----NDKEYI------TNNKINAQM-----VYYLMKCLGYNIVI--DLIESS---YKLCIVDNINK--PYCINKIIQLQDTS--INGEYVYDLETESGTFHAGIGELIVKNTDSIFIN-----------FHIKDENGQERTDK-EALIQT---IAKCQRAAKLINQ-NV---PKP-------------QSIVYEKTF-HPFIL-------VA-KKKYV-------GLLFETN---PNKYFLKSMGIVLKRRDNAPIVKIVVGGIIDYILK---
NRDIDKA------------------------VEYTRNVLSKLM--NGEYPIDKFII------SKTLKS---KYKKPSTIAHKVL--ADRMA----IRDPGNK-P--QI---------------------------------------------------------------------------------------------------------NDRIPF---VYV----------------------------------VKDM-GNK----------------KKKDILQGDLIEHPDYVIQNN---------------------------MKIDYLYYLE----------------HQIIK--PATQILEL---------------------------------------------------------------------------------------------------------MIDSRSVNKL--------------------------------------------FDEYKITEENKRKG------------------RRSILEFVPD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SKKKNVIMNGSKTTKLVLKSQKNRKIE------------------------------------------------------------------------------------------------PKYQNLPYIGNTRKLECKNLGNWMYGDNVKQSSIDDGELDL----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Megavirus_courdo5------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MVLINNSVNNKVLEFQI----------------TDWNS----YHETDP---E--------------DEK------------KYV---IQLFGRTE-DD------KDVCIK------VTD--------FTPYFY----VQIPTNW------KK-----------------------KHVDKFVYYLKRKVS-------WTTNNNPNYAYDLSNSLVNYK--MVEKHN--F-YNFTKK-----KYFNF-V---MLVF-KS---HIAMRE-----FSNVLARP------------------LKTEGLTKEPMLYQRFESNIEPHIRCMHINN-------LSSCG-----------------------------------------------------------------------------------------------------------------------------------------WVT-IDNKNLK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NNSEYSNCDYSYSVQ------------------------WKHIKPSNN-----------------------------------------------------------------------------------------------
------------------------------------------------------------------------DDRMA----------------------------------------------------------------------------------------------------------------------------------------------------------------------PLKIMG----------------------------------------------------------------------------------------------------------------------------YDIECV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SCDH---NFPQA----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DRETDK---------------------------------------------------------------------------------------------------------------------------------------------------------IIQIGITMYRYGSM---------------------ECYEQYILTLK---KCARIKGTN---------------------------------------VECYKTEKGLIRGW-----------------AKKIS-EIRPD----------------------FKGGYNNFGFDDKYIFDR----------------------------------------------------------------------------------------------------------------INRIDREEADKQGINVNELENRFLDEILNIMGKVNNVYLIENEGVNKLTDDSNTRQHEGIRKS--------------------------LTYFEIKNLSSS-ALGD---NE----------LKFFQVPGIISV--D-MMKVI-QRDHRL-----I--GYKL---------DNVSANF-ITQKALRCVE------------TGKNNDDEDLDISIYTESTKALEKDSYIQIMVDDGYSSSPLCEGAKYKVIDIDGITETVYDENEKKNVTYSYQAIKTKISQKDTEQLREVLTNKLLRVYWTFAKDDMHHTL--INKYFNEG-----------DPK------KIRQIAKYCIKDCKLVNLLLA--KLE----------------------------IIVNSVGM-AKVCHVPLSYLFLRGQGVKIFSLVSKK--------------------------CREKNFL----IP----------------VLRRNKK-----------------------DNDGDDDNT------------------------------------------YEGATVITPK-PNVY-----------------------------------------------------------------LS-PIGVLDYSSLYPNSM-----RERNLSPECYINDNKYDNLPGYIYHDVTIILKDKKGKIIRNLDGSPKKEHHRFAQELISDKQINTEMKDVFDKITKTMNNNIETILQQTHFTIKNIEDKIKKEKLITDSRIEDISFNDDFSTKKKAKLIETEKIEMKNRLKIYLEIDEKIKEISIKKKLSIDNIDKSLDADQKSKEIDKIEKTYNENIKNVLEKYIISKEEREEMITME---REKATKNMNDEKSKVYNVVDGKMVRYG--ILPEILTELLNKRKETN-----GRLAV------------------EKD--SFV-KAILNALQLAFKVTANSL--------------------------------------------------------------------------------
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YGQTGA-PTSPIFFIAIAASTTAIGRERLHYA-RKMVED-----------------------------------------------------------------------------------NFPG--S-EVIYGDSVTGDTPLIIRRNGSKDIKITTIENMSDIWENYDVFKAGD--SNRKSKQQAYI--DYQVWTDNGWAKIKRVIRHKTSKKIYRVLTHTGCVDVTEDHSLLDKNKNIIKPKDCTIGTELLHGFMEPRNIH-----------------------------------------ENISIKEAFVWGFFMGDGSCGIYDYEYGTKYSWALNNQDLKILNKCKNYLEEVEDIKFKILDTMKSSGVYKLVPIKKSKNIVKKYRKIFYDSQKYKLVPTKILNS--SSDIKQSFLNGYFEADGCRADKKNIGCLRCDIKGKISAQC-----LFYLIKSLGYNVSI--NTRSDKNQIYRLSYTKSSQRKSPIKIKKIEYLRDT---FKDEYVYDLETESGTFHAGIGELIVKNTDSIFIN-----------FHIKDENGQERTDK-EALIQT---IAKCQRAAKLINQ-NV---PKP-------------QSIVYEKTF-HPFIL-------VA-KKKYV-------GLLFETN---PNKYFLKSMGIVLKRRDNAPIVKIVVGGIIDYILK---NRDIDKA------------------------VEYTRNVLSKLM--NGEYPIDKFII------SKTLKS---KYKKPSTIAHKVL--ADRMA----IRDPGNK-P--QI---------------------------------------------------------------------------------------------------------NDRIPF---VYV----------------------------------VKDM-GNK----------------KKKDILQGDLIEHPDYVIQNN---------------------------MKIDYLYYLE----------------HQIIK--PATQILEL---------------------------------------------------------------------------------------------------------MIDSRSVNKL--------------------------------------------FDEYKITEENKRKG------------------RRSILEFVPD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SKKKNVIMNGSKTTKMVLKSQKN-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Megavirus_courdo7----------------------------------------------------------------------------------------------------------------
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MVLINNSVDHKVLEFQI----------------TDWNS----YHETDP---E--------------DEK------------KYV---IQLFGRTE-DD------KDVCIK------VTD--------FTPYFY----VQIPISWKK-----------------------------KHVDKFVYYLKRKVS-------WTTNNNPNYACDLSNSLVNYK--MVEKHN--F-YNFTKK-----KYFNF-V---MLVF-KS---QIAMRE-----FSNVLARP------------------LKTEGLTKEPMLYQRFESNIEPHIRCMHINN-------LSSCG-----------------------------------------------------------------------------------------------------------------------------------------WVT-IDNKNLK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NNSEYSNCDYSYSVQ------------------------WKHIKPSSN-----------------------------------------------------------------------------------------------------------------------------------------------------------------------DDRMA----------------------------------------------------------------------------------------------------------------------------------------------------------------------PLKIMG----------------------------------------------------------------------------------------------------------------------------YDIECV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SCDH---NFPQA----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DRETDK---------------------------------------------------------------------------------------------------------------------------------------------------------IIQIGITMYRYGSM---------------------ECYEQYILTLK---KCARIKGTN---------------------------------------VECYKTEKGLIRGW-----------------AKKIS-EIRPD----------------------FKGGYNNFGFDDKYIFDR----------------------------------------------------------------------------------------------------------------
INRIDREEADRQGISVNELENRFLDEILNIMGKVNNVYLIENEGVNKLTDDSNTRQHEGIRKS--------------------------LTYFEIKNLSSS-ALGD---NE----------LKFFQVPGIISV--D-MMKVI-QRDHRL-----I--GYKL---------DNVSANF-ITQKALRCVE------------TGKNNDDENLDISIYTESTKALEKDSYIQIMVDDGYSSSPLCEGAKYKVIDIDGITETVYDENEKKNVTYSYQAIKTKISQKDTEQLREVLTNKLLRVYWTFAKDDMHHTL--INKYFNEG-----------DPK------KIRQIAKYCIKDCKLVNLLLA--KLE----------------------------IIVNSVGM-AKVCHVPLSYLFLRGQGVKIFSLVSKK--------------------------CREKNFL----IP----------------VLRRNKK-----------------------DNDGDDDNT------------------------------------------YEGATVITPK-PNVY-----------------------------------------------------------------LS-PIGVLDYSSLYPNSM-----RERNLSPECYINDNKYDNLPGYIYHDVTIILKDKKGKIIRNLDGSPKKEHHRFAQELINDKQINTEMKDVFDKINKTMDNNIETILQQTYFTIKNIEDKIKKEKLITDSRIEDISFNDDFSTKKKAKLIETEKIEMKNRLKIYLEIDEKIKEISIKKKLSIDNIDKSLDADQKSKEIGKIEKTYNENIKNVLEKYIISKEEREEMITME---REKATKSMNDEKSKVYNIVDGKMVRYG--ILPEILTELLNKRKETN-----GRLAV------------------EKD--SFV-KAILNALQLAFKVTANSL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YGQTGA-PTSPIFFIAIAASTTAIGRERLHYA-RKMVED-----------------------------------------------------------------------------------NFPG--S-EVIYGDSVTGDTPIMI-KDKNNNINIVTIKELGEKWKPYDIFKSHEINSNRKYKQQADF--NGEVWTSNGWAKIKRVIRHKTVKKLYRVLTNTGCIDVTEDHSLLDTNKNIIKPIDCKIGTELLHGFPEINNNH-----------------------------------------NKLSLE---IYKEL--DITSELFDCMIESNKKW--NNEKMK---AC---------------------------------FIGSEYRK------QNKNISNEILNC--SKKIKKYFLLGYLG-----NDKEYI------TNNKINAQM-----VYYLMKCLGYNIVI--DLIESS---YKLCIVDNINK--PYCINKIIQLQDTS--INGEYVYDLETESGTFHAGIGELIVKNTDSIFIN-----------FHIKDENGQERTDK-EALIQT---IAKCQRAAKLINQ-NV---PKP-------------QSIVYEKTF-HPFIL-------VA-KKKYV-------GLLFETN---PNKYFLKSMGIVLKRRDNAPIVKIVVGGIIDYILK---NRDIDKA------------------------VEYTRNVLSKLM--NGEYPIDKFII------SKTLKS---KYKKPSTIAHKVL--ADRMA----IRDPGNK-P--QI---------------------------------------------------------------------------------------------------------NDRIPF---VYV----------------------------------VKDM-GNK----------------KKKDILQGDLIEHPDYVIQNN---------------------------MKIDYLYYLE----------------HQIIK--
PATQILEL---------------------------------------------------------------------------------------------------------MIDSRSVNKL--------------------------------------------FDEYKITEENKRKG------------------RRSILEFVPD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SKKKNVIMNGSKTTKLVLKSQKNRKIE------------------------------------------------------------------------------------------------PKYQNLPYIGNTRKLECKNLGNWMYGDNVKQSSIDDGELDL----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Mimivirus-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MPSETIDSTKQFEFQI----------------SDWNS----YHELDQ---E--------------EEE------------KYV---IQLFGRTE-DD------HDVCLK------VTG--------YTPFFY----VEIPKQW------KQ-----------------------RQVDKFVEILKNKVQ-------YHCKKNLDEDFDLSKSLIKYA--MVKKHK--F-YNFRNK-----QLYNF-L---LLVF-KS---HTAMKE-----FSSILARP------------------LEAKGLTNKPMLYQRYESNIEPHIRFMHINN-------LSSCG-----------------------------------------------------------------------------------------------------------------------------------------WAS-IDKDKLK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KIPEYSNCDYSFSVN------------------------WKDVKPSNN-----------------------------------------------------------------------------------------------------------------------------------------------------------------------DDRMA----------------------------------------------------------------------------------------------------------------------------------------------------------------------PFKIMG----------------------------------------------------------------------------------------------------------------------------
YDIECV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SCDQ---NFPQA----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ERPSDK---------------------------------------------------------------------------------------------------------------------------------------------------------IIQIGITMYRYGSM---------------------KCYEQHILTLK---KCAPIEGVN---------------------------------------VECYKKEKGLLRGF-----------------AKKIA-ELRPD----------------------FKTGYNNFGFDDKYIYDR----------------------------------------------------------------------------------------------------------------ILRIDKREGKKQGVNINALKNKFMDEILRTIGKVNNNYLIENEGLDRIPIYTTVKDKKISSKASRFIQIRGGTYVENGNNLKYVQSPG-ITYFEVKNLSSS-ALGD---NE----------LKFIQIPGVLSI--D-MMKVI-QRDHRL-----I--GYKL---------DNVSANF-ITEKADKIIEMPHNQEDSDSEKEDEDTDDKTYDVNIYTKSTKALEKDSYIQIMVNDGYSSSPLSEGAKYKVYDIQTITEKKLNEKTNKEEIFVYQAIKTKICQKDIQQLRETIKNPLLGISWTFAKDDMHHTK--INEYFEEG-----------DPK------KIRQIAKYCLKDCKLVNLLLA--KLE----------------------------IIVNSVGM-AKVCHVPLSYLFLRGQGVKIFSLVSKK--------------------------CREKNFL----IP----------------VLRRKSK-----------------------DNEGDEDET------------------------------------------YEGATVITPK-PNVY-----------------------------------------------------------------LS-PIGVLDYSSLYPNSM-----RERNLSQECYVDDSKYDNLPGYIYHDVEIILKDKKGKILRNIDGTPQKEYHRFAQEIITDEQINRELKDIFDKINTVFENNVAIIQNQKYFTEKNISELIDKHKNISDSKIEDIEFDESLSDKRKNKLVDAEKDSLDKNIGFYQKIKSQIDKIKLDSKIEIDNLSKNLNEEEKSKQINKMELNTKNLISKVFSKYLITEQQREELIVLE---KERAKRSVNAEKAKVYNTVDGITVRYG--ILPEILTELLNKRKETN-----GKLAN------------------EKD--PFV-KAILNALQLAFKVTANSL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YGQTGA-PTSPLYFIAIAACTTAIGRERLHYA-
KKTVED-----------------------------------------------------------------------------------NFPG--S-EVIYGDSVTGDTPIIT-RHQNGDINITTIEELGSKWKPYEIFKAHEKNSNRKFKQQSQYPTDSEVWTAKGWAKIKRVIRHKTVKKIYRVLTHTGCIDVTEDHSLLDPNQNIIKPINCQIGTELLHGFPESNNVY-----------------------------------------DNISEQEAYVWGFFMGDGSCGSYQTKNGIKYSWALNNQDLDVLNKCKKYLEETENIQFKILDTMKSSSVYKLVPIRKIKYMVNKYRKIFYDNKKYKLVPKEILNS--TKDIKNSFLEGYYAADGSRKETENMGCRRCDIKGKISAQC-----LFYLLKSLGYNVSI--NIRSDKNQIYRLTFSNKKQRKNPIAIKKIQLMNETSNDHDGDYVYDLETESGSFHAGVGEMIVKNTDSIFIN-----------FHIKDENGEEKTDK-EALMKT---IAKCQRAAKLINQ-NV---PKP-------------QSIVYEKTL-HPFIL-------VA-KKKYV-------GLLFEKS---PDKYFLKSMGIVLKRRDNAPIVKIVVGGIIDNILK---NRDIDKA------------------------IEYTKIVLDKLM--NGEYPMDKFII------SKTLKS---RYKKPSTIAHKVL--ADRMA----VRDPGNK-P--QI---------------------------------------------------------------------------------------------------------NDRIPF---VYI----------------------------------VKDM-GKK----------------KKKDILQGDLIEHPEYVIANN---------------------------LKIDYLYYLE----------------HQIIN--PASQILEL----------------------------------------------------------------------------------------------M-----MDTKDVQKFF-------------NK----------------------------------YIIDEQNKRKGAQS------------------LTKWMDFSKL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PKESGSKTAKKPYQSQKLQKTKSSNKSQI--DPKYI-----------------------------------------------------------------------------------------------------NLIKNKSRKHECQNMNKWISSTDKCTDDWEPIVE------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Cafeteria_virus--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MASIEFQIYDYRETH----------------QTFED----EDTEKE---M--------------MG-------------EYI---
IQVFGRTQ-DG------ESVYAK------LKD--------FHPRFY----IKIPENW------TN-----------------------RHLKRMETFLKSKDN-------------RKIWNKDRECLVSCS--MVKRKK--A-YGFTNN-----KLYKF-A---VLTF-TN---YYACKK-----FASLFELN-----------------KVYIPGVTTKAITFKIYEANLTPMLRCFHIQD-------IPGCG-----------------------------------------------------------------------------------------------------------------------------------------WVRAENFINIK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TKNKESTCNYEIVLS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YKDIKPIVKESNA---------------------------------------------------------------------------------------------------------------------------------------------------------------PLRICS----------------------------------------------------------------------------------------------------------------------------FDIECD---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SCDG---MFPQA----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NRPNDN---------------------------------------------------------------------------------------------------------------------------------------------------------IIQIGCTYTLLGKS---------------------EPYRQYICTLN---SCDNIEGAT---------------------------------------VESFDVESDLLLAW-----------------LEEIK-NSDAD----------------------ILTGYNIFYFDEKYIMDR------------------------------------------------------------------------------------------------------------------------AKYLGI----EIDIKYLSKLKTF----------------------------------------------------------RCPFKEQKLASS-ALGE---NL----------LRYFDTPGLVHI--D-LMKDV-QKTYNL-----S--SYKL---------DKVASNF-
I----------------------KGN----VKEIKNISTKNKSPVNKFELICDQVN--------DLHQDDYIHLELMESFVSEDIGDKFKIIKLDIENKIITIKTKLDLIEECDFTRGKIYWSQAKDDVPPKE--IFKMQHMG-----------SK-------ERCTVAKYCLKDCKLVNLLIN--KLE----------------------------IVTKNIEM-ANVCYVPLSYLFVRGQGIKLFSLCLKE--------------------------YRKHKFL----FP----------------VVKKPDV----------------------------DLGS------------------------------------------YEGAIVFDPI-PKVS-----------------------------------------------------------------YQ-AHATKDFASLYPSAI-----IQKNMSHET-----------------------------------------------KV--DNDEFDNI-----PGIEYFNAKFKDDTGNW------------------------------------------------------------------------------------------------------------------QYRRF---AKLP-------------------DEFG--VVPTILRTLLGERKAVK-----KLMKV------------------EKD--PFK-YAILDAKQLALKVTANSL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YGQLGA-ATSPVRDRDIAACTTSTGREMLIYA-KKYDEE-------------------------------------------------------------------------------ILPWIING--L-QKAYQTNDTDTIEYLYNKELKDPANEKLKEQIKDFCLKTNDYVFNPIIKYGDTDSIFSCYQYRENTSKISTENKLTLFQEIIKFGKELILPFIPREYQEEFDKLYTKYYGKIRNLKLNSNLKVKPEPTHFKIILPIHDRLKQFLKEYLEESYFPWLWTLHDIFTMDLSYLDYKQRNEIMEVKLFNHGFSQIEKMRLLPSIFSSADKYNLINQIRNFCKNTLKQYYLIPYWKFNSK-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------TNKLEYR------------MDFRNKGDPIIDK-RNLDKS---IDMGIISGELIKKRL----PFP-------------HDLEYEKTF-WPYLI-------LT-KKRYV-------GNKYEFD---RNKYKLDYMGIVLKRRDNAPIVKEICNGIINKLIE---HKDPEGA------------------------YHFLENSLNKMF--NNEYNIKYFLT------SKTLKMK-ESYADWKRIAHVVL--SERIG----ERDPGNK-P--QA---------------------------------------------------------------------------------------------------------GDRISF---AVV---------------------------------EVPPKKGML----------------------QGERIETPDYIKENN---------------------------LTIDYLFYLT----------------NQIEK--PALQFLKL-----------------------------------------------------------------------------------------------------------AVPNV-----------------------------------------------EKRLENLKIIRENE------------------KKGYEDIYKY-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
---------------VNMNNMIDSCLSTNLYEL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Phaeocystis_globosavirus-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MKAKPTVKTKSYKLYDFNVYDGFSKAENLG-------------------------KNGYDK---F--------------KDNK-----------KFI---IQMFGINV-AG------ETVSLI------VED--------FNPFYY----IKVGDDW------GE-----------------------SDRAEFIAHIKNKLG-----------------AYYEDSIVASK--LVKRHK--L-YGFDDN-----KLHTF-I---KISF-TN---TGAYNRAKKMFYVDSTVDG-------------VFKRELIPDGYLYEETKCYLYEANIPPLLKLFHIQE-------ISPSG-----------------------------------------------------------------------------------------------------------------------------------------WIQ-IQSDKIT-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KMRQKSTHCAYEYITS------------------------YKHLKKADK-----------------------------------------------------------------------------------------------------------------------------------------------------------DDIVKYSICSFDIEASSSHGDFPV------------------------------------------------------------------------------------------------------------------------------------------------------------PIKDYKKLA-------------------------------------------------------------------------------------------------------------TNILEYYNEMEDKTKFDVTCF-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
---------------------------------------------------------------------------------------KKLIDAGYGYERCPDIATVYPKLKNISKEQLDNIFSNFMLYIPAKDQSRKDYIKENEESDTDSDN----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DDEDDK--------------------------------------------------------------------------------------------KENDGADEAAAFHKRHKKVKKYHKTANLLQIIHDDKCENDTKLFELNKALTKFYPELEGDMVTFIGMTFLNYSEK---------------------KPHTRYIIVKG---GCEVPEKYKSWVLENNVK------------------------------IIEKTTEKGVLLEF-----------------TKIMT-LENPH----------------------IVTGYNINGFDFDFMFKR------------------------------------------------------------------------------------------------------------------------SKEIGCVEDFLKLSKNIDEVCMTKDWK------------------------------------------------------TGEMEIAKNKIVLASGE---YN----------LSFINMPGRIIV--D-MCVVF-RREYTL-----S--SNKL---------DYVSSYF-I----------------------SDS------------VKKIDVDKENNQTRIYSK--------NLTGLTVGCYVKFDEVSHSTNNYKKGQKYEILDINLDTASFLIDSAEELDLKKYKINWGLAKDDVSVQE--IFELANKS-----------DI-------DRFTVGKYCIGDCDNVIWLLI--KVD----------------------------IITDKVEM-SNLCDVPLNFLLQRGQGIKLQSYVSKK--------------------------CGEKNTL----MP----------------IVEKNLN-----------------------------DGG------------------------------------------YEGAHVFNPK-TGLY-----------------------------------------------------------------LEDPVACVDYSSLYPSSM-----ISENLSHDS---K--------------------------VWTKEYDLSDNLIHSTGEK--DADENFIY-----DNLPNYTYVDVKYDTYEYLRKTP--KAAEKKT-----------------------------------------------------------------------------------VV--------------GYKIC---RFAQ-------------------FPKGKAIMPAILEDLLSARKATK-----KLMGK------------------EED--PFK-QNIYDKRQLSIKVTANSL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YGQCGA-RTSAFYEKDVAASCTAIGRKLLFYG-KDVIEG------------------------------------------------------------------------------------CYN--NVEITLSDGV-------------------------------------------------------------------------------KVVTKAEC-----------------------------------------------------------------------------------------VYG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
--DTDSVFFK-----------FNLKTPEGKRIINK-QALIYT---IELAKQAGELATK-FL---KKP-------------HDLEYEKTF-WPFNL-------LS-KKRYD-------GMLYEND---PEYCKLKSMGNVLKRRDNAPIVKDIYGGVVGILMK---DKSLPKS------------------------IKFVKESVQNMI--DEKYPIEKLLV------TKALRG---YYKNPKQIAHKVL--ADRIG----VREQGNK-P--GA---------------------------------------------------------------------------------------------------------GDRMNY---AYI----------------------------------KNPNKKAL----------------------QGEKIETPEFIKDNE---------------------------LKLDYGHYIT----------------NQIMK--PLLQLYAL----------------------------------------------------------------------------------------------E------------------------------------------------------------------------------------------------LENIQEFKDK----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QFNIKEYNTDKKVILW--EEEII-----------------------------------------------------------------------------------------------------KLKEKWPDPEKYVKKYEELRCKEVKALIFDKYLKGLK---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Chlorellavirus_OR0704----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSFDPGIISTKRAYDTKSHNILYYHLSSDMASLTVFP----------------TDWRS----GDEGEQ---F--------------R--------------------INLFGKTP-DG------KTACIR------IR---------FTPVFL----LEMPATW--------------------------------SPSRQKLFITETAI--------------------KYGAIKDMCLPVKKKS--M-WGFDGG-----VMRNL-A---QFAF-PT---LEKMRK-----AKYGLKRD------------------------------YQIYESNVDPIVRLFHIRK-------INPAG-----------------------------------------------------------------------------------------------------------------------------------------WVQ-IKQSYPV----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------MTRISRSDIEVDCN-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FTTVCGSELTTPP---------------------------------------------------------------------------------------------------------------------------------------------------------------PLVIAS----------------------------------------------------------------------------------------------------------------------------WDIETY---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SKER---KFPLS----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SNPTDY---------------------------------------------------------------------------------------------------------------------------------------------------------VTQIATSFQRYGEE---------------------EPYRRVVVCFK---DTGKVDGVE---------------------------------------IVSCSEEQDMINAW-----------------MTIVS-EEKTD----------------------VLIGYNVFQYDWKYVSGR-------------------------------------------------------------------------------------------------------------------------AQMLVDDASADDTVFVDTLGRLLEG-------------------------------------------------------GGAVVERELASN-AFGQ---NF----------FYYLDTPGVIQL--D-LLQWM-RKNRNL-----E--SYSL---------NNVSKLY-L----------------------GDQ---------------------------------------------------------------------------------------------------KDDLPAMK--IFEKFEGG-----------PE-------DRAVIAKYAAQDTLLPLKLLS--KLA----------------------------IFEDITEM-ANAVKVPVDWIGFRGQQVRAFSCLFGK--------------------------AREMNYA----IP----------------DDKAWAA-----------------------------EGK------------------------------------------FEGATVLEPK-KGAY-----------------------------------------------------------------FT-PIAALDFASLYPSII-----RAHNMSPETLV----------------------------------------M----DA--RYKNLPGV-----EYYEIGT----------------------------------------------------------------------------------------------------------------------------GIGTF---RYSQ-------------------QSQG--VVPALLDDLAKFRKNAK-----KLMAA---------------AHKEGD--DFK-EALYDASQRSYKVVMNSV------------------------------------------------------------------------------
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YGFLGA-SKGFLPCVPIAASVTATGRNMIDVASRRAIEL------------------------------------------------------------------------------------LPG--S-EVIYGD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TDSIMVK-----------MKL----PE-GKNQ-EDINDH---FEVAKWLAGEITK-EY---RAP-------------NDLEFEKIY-YPYIL-------YS-KKRYA-------AIKYEDP---EEKGKVDVKGLALVRRDFSPITREILKESLDTILF---AKDTPTA------------------------VKDTREKIRKVL--DNEYPMEKFVM------SKTLKTG---YKN-EMQPHLIV--ANKIF----DRT-GFP-V--PS---------------------------------------------------------------------------------------------------------GARVPF---VYV----------------------------------EDKD-NID--------------------AKQSMRAEDPKYAMDNG---------------------------LIVDRLFYIN----------------HQLLK--PLTSLFEP----------------------------------------------------------------------------------------------LVDHPEKELFGHVDVVGKIEALTTRHKAE------------------------------------LKDTKRVKKNKANN------------------QIEITSFFKP--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KTLKL-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Chlorellavirus_NEJV3------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDIYP----------------VDWRS----GDENGQ---F--------------K--------------------ITMFGKTV-
DG------KSSCVR------IR---------FTPSFL----LEMPDSW-------------------------------SAPRQRLFITETVMK---------------------YGAIKDMCLPVQRKSL---WGFDNG-----KSRNM-A---QFAF-PT---MEAMRK-----AKYGLKGN------------------------------HQVYESSVDPIIRLFHLRK-------LSPSG-----------------------------------------------------------------------------------------------------------------------------------------WVR-VSQSYPA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MTRVSRCDIEVECN-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FTQVGPSDVVSTP---------------------------------------------------------------------------------------------------------------------------------------------------------------PLVIAS----------------------------------------------------------------------------------------------------------------------------WDIETY---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SRER---KFPLA----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SNPDDY---------------------------------------------------------------------------------------------------------------------------------------------------------VTQIATSFQRYGEA---------------------EPFKRVVFCLN---DTAGVPGVE---------------------------------------IVSCSQEADVINAW-----------------MDAIT-KEKTD----------------------VLIGYNVFQYDWKYVYGR-------------------------------------------------------------------------------------------------------------------------AQMLVDDATAEETVFPEKLGYLLED-------------------------------------------------------GGKVVERELASN-AFGQ---NF----------FYYLDTPGVIQL--D-LLQWF-RKNRNL-----E--SYSL---------NNVSKLY-L----------------------
GDQ---------------------------------------------------------------------------------------------------KDDLPAMK--IFEKFEGD-----------AE-------DRAVIAKYAAQDTLLPLKLLS--KLA----------------------------IFEDVAEM-ANAVKIPMDWVGFRGQQVRAFSCLFGK--------------------------AREMGYA----IP----------------DNKAWPA-----------------------------EGK------------------------------------------FEGATVLEPK-KGAY-----------------------------------------------------------------FE-PIAALDFASLYPSII-----RAHNMSPET---------------------------------------------------IVMEPKFANVPGVEYYEIQT----------------------------------------------------------------------------------------------------------------------------GIGKF---RYSQ-------------------KSQG--VVPALLDDLAKFRKNAK-----KLMAQ---------------AHKEGD--DFK-EALYDASQRSYKVVMNSV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YGFLGA-SKGFIPCVPIAASVTATGRNMIDVAARRALEL------------------------------------------------------------------------------------LPG--S-VVVYGD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TDSIMVK-----------MKL----PE-GKDQ-NNINDH---FEVAKWLAGEITK-EY---KAP-------------NDLEFEKIY-YPYIL-------YS-KKRYA-------AIKFEDP---NEKGKVDVKGLALVRRDFSPITRDILKESLDTILF---AKDTPTA------------------------VKDTREKIRKVL--DNEYPMEKFVM------SKTLKTG---YKN-EMQPHLIV--ANKIL----ERT-GVP-V--PS---------------------------------------------------------------------------------------------------------GARVPF---VYV----------------------------------EDDD-KID--------------------LKQSMRAEDPTFAQN-NG--------------------------LVVDRLFYID----------------HQLLK--PLVSLFDP----------------------------------------------------------------------------------------------LVEDPEKELFGH-EDVVEKIEM-LKNVHNKQ----------------------------------LKVTKRVKKNASNR------------------QHEITSFFKT----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KGK----------------------------------------------------------------------------------------------------------
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Pandoravirus_salinus---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MASCTAEAPKVDLGDRAKIMSNLFGVRETVTRVPARLRVQLLDPLVRDANGSRDRRQIEDAGRPVARYHHADHRESRQFDGILDDG----------------TLIKAPGADDDAEGE---P--------------DDDDGWHDEGQRRERPPLVDTLLLLNGVDDEG------RTVCVS------VRG--------MRYAIY----VLCPPSWGV-----------------------------AHMQALAATIEGYYG--------IRRGGVTYQQRPLHHMLGWEPETNDLTRTRR-HNYCVLGFGSARVMEWAA---NAIDGRE---AKLCRR-----LREPLNER--------------------------DMRSLQVYERRVDPVHKALERLG------GLQPCS-----------------------------------------------------------------------------------------------------------------------------------------WFD-VQRWRIP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DLYHTHAQIEVEAD-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ARDIVPRPEIDAMA--------------------------------------------------------------------------------------------------------------------------------------------------------------PVWKAS----------------------------------------------------------------------------------------------------------------------------WDVECY--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
-------------------------------------------------------------------------SRDG---SFPRA----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DHPRGC------------------------------------------------------------------------------------------------------------------------------------DHTICINTYFSQHRTDGRPPRVVQTSHHFGAVRVHRPVDAERDRVD----------DPRQRAHWSVFEMNRAAPADTMATETADAQQQQQQQEQQPRSHREVY---------------VMQCATELEAIEGW-----------------RDLIVLDVQPS----------------------VVEGYNTDAFDFDWLGTR---------------------------------------------------------------------------------------------------------------------AQRCARYGVRSRLFEAGVLIGE--------------------------------------------------------------HTPMRRKDLDSA-AKGS---NT----------LNFIPMPGRILI--D-MYHIV-KAEKRL-----E--SYTL---------DDVCRSI-F----------------------AKDESLR-----------------------------------------------------------------------------------------------KIDVPPEE--IFDHYASG-----------DLD------RRAVVVEYCARDCRLPLALEE--HLM----------------------------TLTGVVEM-ARITRTPLPLMLISGQQVKTWSQIVYE--------------------------AHTMGYV--VNAP----------------EGRDRSGGGTRDWLRGAYGVGDHGVGDQWLPGVIAMASIRAGGGNADGHIMPQDGGKVAGAADAEEG--------------YAGATVLQPR-AGYY-----------------------------------------------------------------DV-PIVTLDYQSLYPSIM-----EANNLCPSTRVTAEP------------------------------------IHRELARHCREVREATSEVLRADGAGQDATALNRVFASRPDWLPGQFAVDTDRR-------------------------------------------------------------------------------------GIQRTVAYREVTPAAGRTH---VFVQ-------------------HVQG--VVPRILTALKNQRKRVR-----ADQKAY-----------------EKG--TAL-WGVYENRQLGIKITANCFPADDHEILTETGFMNYAAVTEHFKRHAHLSVACYVDGQLQYHDITEANVVANTGDHRLVQFEAGSSTGKRATTNGVSLCCTDNHRIYARVGPTWGNRIWRRKGTESQESAAPPFTIQSAGDILDAGTRDPSTMVQFTAVCSKGVTLDGGDLPFVEALGLRTEDQVDAFVELYGYWLGDGWLDVSCQAIAFSPVKTADSAYLAALFARLPLPLLTKDTRGPGAIGAFVTPEPAGVKRRARYTAWTTPHRHYIYTPSWWRYFAEQYGHKYSGAALEHVIQGALRSGADLPARRPDAKPSTGKARTLASSTSMGGGRLSAACATRRNRINDGVAERVCYSDHCASAGVWQPLTTAFPRHSPKGSGKATYGGKCRKCVSARAYQNRIARRTQLAARYDAMFAANTGKRQTALGAEEVKSAKWMWSWVWRRLHPDRLRLLLRGLRMADGDMAGGDRGGGAIYTSSRRFAEEVVRVAMHAGYTAMIQPRCAAGDVTGLNQKGVPIVATAQNWVVNYSDFTREAQPKITVATQMSSAPYHGTVWCVNVPVEPHLIVVRRIVQRYGVSVPSRAVVVGNSVYGFLGAVKRGRMP
CVEVSESVTCIGRDMINAT-KAYVETHLPRYVSGLLDDPALVAAAAERQRAKERLDASFASAGLGAVAVTDVALAQPALEPAAKDDRSEREKNRDALLDALTSASVKPGDITG--A-TVVYGDSVGADTPLLLRFDGKHVDYVRADQVDGILARGDTSAAASLWSAYQGDKEAFCLARPVEVWTERGWTAVNRVIRHRAGKKMFRVLTHTGCVDVTEDHSLLDPNAEKVKPTEVSVGSALLHADLPTHECATASLKSRVPMSTQDITDDDGDDDSAKVSAASSTSADGSVLVSAADKAHAWAMGMFFAEGSCNEHPRDNCTQYCWRIANKDMALVRMAFDGLEGRYPGVTFSISGPCTDGMAYVVANGPGKMGLVANYRTAFYDPVYALKRVPTEILNAHVEIKRAFIRGYFAGDGNKKLYGADGTYCGSRCGGKGKIGMAGIYYLLSACGYLASVDTCGGPERDTYRINFCDAATARRTQRKPADTVKKIIPLDSAAFDGAYVYDLETANHHFAAGIGRLVVHNTDSVMIK-----------FHG------VPATR-EGVEVA---LQLGVAASDYITT-KF---PDQ-------------IILDTEKAY-WPYVL-------FR-KKRYV-------GRMWTLD---GKPPYIDAKGVEVKRRDNWAGMRKTYKACLEAMME---RMDINAV------------------------KDIVLRLVCDLK--GDRVSLDDYKI------SKSLKRDYSKCK--SAPPHVVV--RDKIA----RRNPGSE-P--LA---------------------------------------------------------------------------------------------------------GNRVYF---VIT----------------------------------IDDRLKKK-----------------------SARAEDPAYVAANPRL-------------------------ARIDRLYYLD-----------------SLKN--PFGALLEP------------------------------------------------------------------------------------------------------------CFDNPEQL-------------------------------------------FADAAVFIANQQKG------------------QAPITQWMGG---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KRAAVPTTEAEVEAAEAR-----------------------------------------------------------------------------------------------------ERAQIAARVKRRRNDQTYVPAAVLKQQKTEARK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AARKKPPPTTGPLTAFVKKRPAS------------------------------------------------------------Pandoravirus_dulcis--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MRERPRPPRDTAVEAPTVDLGARAKTMSGLFGVRETVTHVPAQLRVQLLDPLVRDANGSRDRRQIEDAAQPVAYYHHGEHRESRQFDGFLDDG-------------
TLVSAPGDAMAETDGDDN------------------GDDGWHDEGERRERTPPADTLLLLNGVDG-EG------RTVCVS------VKG--------MRYAIY----VLCPATWGV-----------------------------EHMQALAATVEGYYG--------IRRGGVTYQQRALHHMLGWEPETNDLTRTKR-HNYCVLGFGSARVMEWAAN--AIHGGGN---GKLCSR-----VRLPLTER--------------------------DMRSLQVYERRVDPVHKALERLG------GLQPCS-----------------------------------------------------------------------------------------------------------------------------------------WFD-VRRWRVP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ELYHTHAQIEVEVD-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ARDIVPRPEIDVMA--------------------------------------------------------------------------------------------------------------------------------------------------------------PVWKAS----------------------------------------------------------------------------------------------------------------------------WDVECY------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SRDGSFPRA----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DHPRGC------------------------------------------------------------------------------------------------------------------------------------DHTICINTYFSQHRSDGRPPRVVQTSHHFGAVRVHRPVEAERDRVD----------DPKQRERWGVREMDLTSAGRPEATATTAGHMVDAEEEPSQREVY------------------VMQCATELEAIEGW-----------------RDLIVLDVQPS----------------------VVEGYNTDAFDFGWLGVR---------------------------------------------------------------------------------------------------------------------AERCARYGVRSRLFEAGVLIGE--------------------------------------------------------------HTPMRRKDLDSA-AKGS---NT----------LNFIPMPGRILV--D-MYHIV-KAEKRL-----E--
SYTL---------DDVCRAI-F----------------------PKDESLR-----------------------------------------------------------------------------------------------KIDVPPEE--IFEHYASG-----------DLD------RRAIVVEYCARDCRLPLALEE--HLM----------------------------TLTGVVEM-ARITRTPLPLMLISGQQVKTWSQIVYE--------------------------AHTMGYV--VNAP----------------ENRDADGGTRDWLRGAYGAGDHGGVGDAWLPGVIAMASIRAGGGNADGHAVPTAGGKVTGVAADAEG--------------YVGATVLQPR-AGYY-----------------------------------------------------------------DV-PIVTLDYQSLYPSIM-----EANNLCPSTRVTSRT------------------------------------VHAQLARHCREVREPVSEVLRADGAGQDDGALNRVFASRRDWLPGQFAVDTDRP-------------------------------------------------------------------------------------GVPRTVAYREVSPAPSRTH---VFVQ-------------------HVQG--VVPRILTALKNQRKKVR-----ADQKAY-----------------EKG--TAL-WGVYENRQLGIKITANCFPADDHEILTETGFMNYAAVVEHFKHHARLSVACYVDGQLQYHDIAESNVVANTGDHRLVQFEAGSSTGKRATTNGVSLCCTDNHRIYARVGSTWGNRIWRRKGTESQESAAPPFTIQSAGDILAAGTRDPSTVVQFTAACSKGVALDGDDLPFAATLGLHTEDQIDAFVELYGYWLGDGWLDVSCQAIAFSPVKTADSAYLAALFARLPLPVLTEDTRGPGAIGAFITPKPSEARQRARYSAWAKPHRHYIYTPSWWRYFAEQYGHKYSGAALEHVMQEALRSGSDLPARRPDAKPLAGKARALATLSPVRDSRPSGACAAQR---------------------------------------------------------NYIARRNKLTARYDAMFAANTGKRRTTPDAEEVRSAKWMWSWVWRRLHPGRLRLLLRGLRIADGDMAGGDRGGGAIYTTSRRFAEEVVRVAIHAGYTAMIQPRCAAGAVTSLNQKGVPIVATTQNWVVNYSDFTREAQPKITVATQMSSAPYHGTVWCVNVPVEPHLIVVRRIVQRHGVSVPSRAVVVGNSVYGFLGAVKRGRMPCVEVSESVTCIGRDMINAT-KAYVETHLPRYVGGLLDDPALVAAAAERQRAKERLDAGHATADLSAVTLSPPK-----------DDRSDREKNREALLDALAAAGVTPCDITG--A-TVVYGD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TDSVMIH-----------FHG------VPKTR-EGVEVA---LQLGVAASDYITT-KF---PDQ-------------IILDTEKAY-WPYVL-------FR-KKRYV-------GRMWTLE---GKPPYIDAKGVEVKRRDNWAGMRKTYKACLEAMME---RMDINAV------------------------KDIVLRLVCDLK--GDRVSLDDYKI------SKSLKRDYSKCK--SPPPHVVV--RDKIA----RRNPGSE-P--LA---------------------------------------------------------------------------------------------------------
GNRVYF---VIT----------------------------------IDERLKKK-----------------------SARAEDPAYVAANPRL-------------------------ARIDRLYYLQ-----------------SLAN--PFGALLEP------------------------------------------------------------------------------------------------------------CFENPQQL-------------------------------------------FADAAVFIANQQRG------------------QAPITQWMGG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KRAAVAPTCEADIEAAEAR-----------------------------------------------------------------------------------------------------ERAQIAARVKRRCTDQTYVPAAVLKQQKTEARK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AARKAPPPKTGPLTAFVKKRPAA------------------------------------------------------------Feldmannia_virus-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MRGSTTSQVLLVRPRSGI----------------PRWYR-------------------------------------------------SSRWLKTG---------GPPTFK------SKT--------FCPWFY----VDLNEFF--------------------------------TFAQFKSVVAEQYW--------------------ARNVVSCE--LVARKRF---IGFADG-----KSFDYVL---MTFTGLI---PMYCSR-------KYLRTL-----------------------------KVHLHEDSVDPLLKFFHSSG-------IKPSS-----------------------------------------------------------------------------------------------------------------------------------------YFEMDGFVVWN---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GQGKTHCSREYYVA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VQNLRPSADSGSPP--------------------------------------------------------------------------------------
------------------------------------------------------------------------PIPMCS----------------------------------------------------------------------------------------------------------------------------YDIESS----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DPASDY---------------------------------------------------------------------------------------------------------------------------------------------------------VFQVSLCFGFLGEDLDSRS----------------AISDSFVICVG---DVESVEGTP---------------------------------------ILCVQNELQLLKKF-----------------REIVV-ERQVC----------------------ILVGYNSYQFDGQFLYKR-----------------------------------------------------------------------------------------------------------------------AVDTYNYQDFCKIGFLRND---------------------------------------------------------------KASLKTKVLESS-ALGK---NE----------LSQFVIPGRVEF--D-ALMTV-RRNHKL-----G--SYKL---------DSVCRHF-F----------------------GGK---------------------------------------------------------------------------------------------------KDDVSYEY--ILSACESK-----------DPK------KLGVIAKYCLQDAWLTLRLVS--SLK----------------------------DVYNGLEM-SKLCVVPLSYIESRGQQIKCLSLILDR---------------------------VHGEFVCNKASR----------------VLPGGVK--------------------------------------------------------------------------FQGATVIDAT-KGFH-----------------------------------------------------------------NKDPVVCLDFASLYPSII-----RWKNLCYTT-----------------------------------------------YL--DSDEFANI-----PGVHYERFEISPG----------------------------------------------------------------------------------------------------------------------VYETF---ATRP-------------------GHKG--ILSAIEEDLGEARRQTK-----AAMKV------------------EKD--SKK-LQLLNSKQLAQKVTMNSL----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
----------------------------------------------YGFCGT-VNGCLPLVAIAAAVTCTGRSMIKTT-ADFIRT------------------------------------------------------------------------------------EMG--G-TVIYGD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TDSVMCT-----------FPA-PQTVRGQGKR-ALLGHA---YAMGLSAEEKSLS-LF---GHP-------------VKLEYEKIY-FPFLL-------IS-KKRYA-------CMSYDRP---DSEPKMSTSGLVTVRRDNAKVVRDCANGVISILME---GRGQGDV------------------------VEYVKTVLSKLE--NSEIGVEDLTI------SNELKKHPDQYA--TPSAHSVL--AGKLN----ARAKNQK-LYREIVRPVVEQGGVPSLGTAYGVLEGVRRKFSFDQRRDVSYEEFLRDLANGRVAEKLKGSAPQVSECESLVGSTEDKLIQEGIRTEKILNDMYREFSVFDRMYWEAQSLGSRVPY---VIV----------------------------------RGNG-SVN------------------------ERSEDPRFVEMADH--------------------------LRIDTKYYID----------------QQLKN--PILGIVEA----------------------------------------------------------------------------------------------F--------PDGRASLERV----------------------------------------------FREFSRRADNANKG------------------RREITSFFER---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SVRSKV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Pithovirus---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MELTVHAYDWSVRDLAIPSGGFETTI----------------YAWCL----DRESKP----------------------------------------HLLRIPF---------LHVCYF------E----------LKPILVSGRSVPWDE---------------------------------NRASHLLMKITTLLG--------------------
DNKPINAR--FVRKPKLYYFQGK--------RTFPM-I---QMVF-SS---EFSLAA-----FRKIASRP----------------FHFTGANGKKISVSGQLWEDRQSPVRRLLTERD-------CRFAQ-----------------------------------------------------------------------------------------------------------------------------------------WFR-ISVVEVP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ENHKVSTISEFQG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DWRTLKSYSAIESKGWVT-----------------------------------------------------------------------------------------------------------------------------------------------------------APKIFS----------------------------------------------------------------------------------------------------------------------------FDIECY-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SDNHKAMPKE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YAITNV---------------------------------------------------------------------------------------------------------------------------------------------------------VYMISCVVFRNKT----------------------NEREKYLIVMG---KVGEIPGTT---------------------------------------IIEVETEEQLCFAF-----------------ANLIR-ETDPD----------------------IVTGFNIFGFDYPYLYFR-------------------------------------------------------------------------------------------------------------------------LGMYLQDWPAMGRLRSKA--------------------------------------------------------------KTILSEINWKSS-AYSR---QR----------YYMMQMEGRVNF--D-LYTLV-RREMKL-----L--RYNL---------DTVSKQY-L----------------------GRG---------------------------------------------------------------------------------------------------KHDISAIE--MFNIYEKY-----------CAHPDKFQAEFRSVAEYCIEDSLLVVDLIE--KLN----------------------------VWIWLVEF-
SSVTGVSVSDLFTRGQQMRCFSLIQHL--------------------------TSQKGIV----IDT---------------ITQSRDK--------------------------------------------------------------------------YSGAYVSDPI-PGLY-----------------------------------------------------------------DY--IACIDFNSLYPSIM-----IAYNMCYTT-----------------------------------------------LI--HPSDEKEVLKVLTPDDYWVVEWDETDEETKVEKH--------------------------------------------------------------------------------------------------------------FRHLF---VKEH-------------------IKKG--LLPELVAGLIQERTDVR-----NSMRG------------------EKC--QIT-LDTKEKRQLGLKVVANST--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YGFTGA-RQGRLPIPQIAASVTAMGRKLIHQG-NDYLKE------------------------------------------------------------------------------------KYG--M-DAVYND------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TDSIFFP----------------------TQC-SNYADA---MKRGEELAKEVSD-IF---PPA-------------LNLGLEKVG-RMFCI-------K--KKKYA-------FWPVNRDGTFKNEAEIIHKGTIKARRDNCQWQQNLFYTTLMDCLN---RQGLKEM------------------------FENISAQVIETY--QRKFSWQDFVV------VKSLGE---NYKD-KNNCMKIF--SEALA----A-R-GAP-A--NP---------------------------------------------------------------------------------------------------------GDRLDY---IIV----------------------------------QNEG-QYL-----------------------GNKMMLPEHFLQ-DNEEK----------K------------VEIDYDYYIE----------------HFGIK--NIEQLYQI----------------------------------------------------------------------------------------------A--------HKE-QIEQH-----------EH----------------------------------FHVEFSAKYALQQF------------------LTAFPQYVGL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LQYQPTWKATHEHLFEA--LKARH-----------------------------------------------------------------------------------------------------IGKNRQILHKLFVSRVKRKTSRICLNPVKQQMVL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
---------------------------------------------------------------------------------------------------------------------------------------------------------------VKAKREH----------TNELKHISQNGQLSSSEILH-YIRHGAPQSE------------------------------------------------------Herpesvirus_5-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MFFNPYLSGGVTGGAVAGGRRQRSQPGSAQGSGKRPPQKQFLQIVPRGVMFDGQTGLIKHKTGRLPLMFYREIKHLLSHDMVWPCPWRETLVGRVVGPIRFHTYDQTD----------------AVLFF----DSPENV---S--------------PRYRQHLVPS-----GNV---LRFFGATE-HG------YSICVN------VFG--------QRSYFY----CEYSDTD--------------------------------RLREVIASVGELVP-------------------EPRTPYAVS--VTPATKTSI-YGYGT------RPVPD-L---QCVSISN---WTMARK-----IGEYLLEQ-----------------------------GFPVYEVRVDPLTRLVIDRR-------ITTFG-----------------------------------------------------------------------------------------------------------------------------------------WCS-VNRYDWR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QQGRASTCDIEVDCD-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VSDLVAVPDDSSWP----------------------------------------------------------------------------------------------------------------------------------------------------------------RYRCLS----------------------------------------------------------------------------------------------------------------------------FDIECM---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SGEG---GFPCA----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
EKSDDI---------------------------------------------------------------------------------------------------------------------------------------------------------VIQISCVCYETGGNTAVD-----------------QGIPNGNDGRGCTSEGVIFGHSGLHLFTIGTCGQVGPDVD----------------------VYEFPSEYELLLGF-----------------MLFFQ-RYAPA----------------------FVTGYNINSFDLKYILTR------------------------------------------------------------------------------------------------------------------------LEYLYKVDSQRFCKLPTAQGGRFFLHSPA----------------------------------------------------VGFKRQYAAAFP-SASH---NN----PASTAAT-KVYIAGSVVI--D-MYPVC-MAKTNS-----P--NYKL---------NTMAELY-L----------------------RQR---------------------------------------------------------------------------------------------------KDDLSYKD--IPRCF-VA-----------NAE------GRAQVGRYCLQDAVLVRDLFN--TIN----------------------------FHYEAGAI-ARLAKIPLRRVIFDGQQIRIYTSLLDE--------------------------CACRDFI----LPNHYSKGTTVPETNSVAVSPNAAIISTAAVPGDAGSVAAMFQMSPPLQSAPSSQDGVSPGSGSNSSSSVGVFSVGSGSSGGVGVSNDNHGAGGTAAVSYQGATVFEPE-VGYY-----------------------------------------------------------------ND-PVAVFDFASLYPSII-----MAHNLCYST---------------------------------------------------LLVPGGEY-----PVDPADVYSVTLE----------------------------------------------------------------------------------------------------------------------NGVTH---RFVRAS-----------------VRVS--VLSELLNKWVSQRRAVR-----ECMRE------------------CQD--PVR-RMLLDKEQMALKVTCNAF--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YGFTGV-VNGMMPCLPIAASITRIGRDMLERT-ARFIKD---------------------------NFSEPCFLHNFFNQEDYVVG-----------TREGDSEESSALPEGLETSSGGSNERRVE--A-RVIYGD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TDSVFVR----------------------FRG-LTPQAL---VARGPSLAHYVTACLF---VEP-------------VKLEFEKVF-VSLMM-------IC-KKRYI-------GKVEGASG-------LSMKGVDLVRKTACEFVKGVTRDVLSLLFE---DREVSEAAVRLSRLSLDEVKKYGVPRGFWRILRRLVQARDDLY--LHRVRVEDLVL------SSVLSKDISLYRQ-SNLPHIAV--IKRLA----ARS-EEL-P--
SV---------------------------------------------------------------------------------------------------------GDRVFY---VLTAPGVRTAPQGSSDNGDSVTAGVVSRSDAIDGTDDDADGGGVEESNRRGGEPAKKRARKPPSAVCNYEVAEDPSYVREHG---------------------------VPIHADKYFE-----------------QVLK--AVTNVLSP----------------------------------------------------------------------------------------------V-------------------------------------------------------------------------FPGGE------------------TARKDKFLHM----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VLPRRLHLEPAFLPYSVKAHECC---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Herpesvirus_1--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MFSGGGGPLSPGGKSAARAASGFFAPAGPRGAGRGPPPCLRQNFYNPYLAPVGTQQKPTGPTQRHTYYSECDEFRFIAPRVLDEDAPPEKRAGVHDGHLKRAPKVYCGGDERDVLRVGSGGFWPRRSRLWGGVDHAPAGFNPTVTVFHVYDILENVEHAYGMRAAQFHARFMDAITPTGTVVTLLGLTP-EG------HRVAVH------VYG--------TRQYFY------------------------------------------MNKEEVDRHLQCRAPRDLCERMAAALRESPGASFRGISADHFEAEVVERTDVYY-YET--------RPALF-Y---RVYV-RS---GRVLSY-----LCDNFCPA------------------------------IKKYEGGVDATTRFILDNP------GFVTFG-----------------------------------------------------------------------------------------------------------------------------------------WYRLKPGRNNT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
LAQPRAPMAFGTSSDVEFNCT-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ADNLAIEGGMSDLP----------------------------------------------------------------------------------------------------------------------------------------------------------------AYKLMC----------------------------------------------------------------------------------------------------------------------------FDIECK---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AGGEDELAFPVA----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GHPEDL---------------------------------------------------------------------------------------------------------------------------------------------------------VIQISCLLYDLSTT---------------------ALEHVLLFSLG---SCDLPESHLNELAARGLPTPV---------------------------VLEFDSEFEMLLAF-----------------MTLVK-QYGPE----------------------FVTGYNIINFDWPFLLAK-----------------------------------------------------------------------------------------------------------------------LTDIYKV---------PLDGYGRMNG--------------------------------------------------------RGVFRVWDIGQS-HFQK---RS------------KIKVNGMVNI--D-MYGII-TDKIKL-----S--SYKL---------NAVAEAV-L----------------------KDK---------------------------------------------------------------------------------------------------KKDLSYRD--IPAYYAAG-----------PA-------QRGVIGEYCIQDSLLVGQLFF--KFL----------------------------PHLELSAV-ARLAGINITRTIYDGQQIRVFTCLLRL--------------------------ADQKGFI----LP----------------DTQGRFRGAGGEAPKRPAAAREDEERPEEEGEDEDEREEGGGEREPEGARETAGRHVG-----------------------YQGARVLDPT-SGFH-----------------------------------------------------------------VN-PVVVFDFASLYPSII-----QAHNLCFST---------------------------------------------------LSLRADAVAHLEAGKDYLEIEVGG------------------------------------------------------------------------------------------------------------------------RRLFF---VKAH-------------------VRES--LLSILLRDWLAMRKQIR-----SRIP-------------------QSS--PEE-
AVLLDKQQAAIKVVCNSV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YGFTGV-QHGLLPCLHVAATVTTIGREMLLAT-REYVHA-----------------------------------------------------------------RWAAFEQLLADFPEAADMRAPGPYSMRIIYGD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TDSIFVL----------------------CRG-LTAAGL---TAMGDKMASHISRALF---LPP-------------IKLECEKTF-TKLLL-------IA-KKKYI-------GVIYGGK--------MLIKGVDLVRKNNCAFINRTSRALVDLLFY---DDTVSGAAAALAERPAEEWLARPLPEGLQAFGAVLVDAHRRIT--DPERDIQDFVL------TAELSRHPRAYTN-KRLAHLTV--YYKLM----ARR-AQV-P--SI---------------------------------------------------------------------------------------------------------KDRIPY---VIV---AQTREVEETVARLAALRELDAAAPGDEPAPPAALPSPAKRPRETPSHADPPGGASKPRKLLVSELAEDPAYAIAHG---------------------------VALNTDYYFS----------------HLLGA--ACVTFKAL----------------------------------------------------------------------------------------------F--------GNNAKITESLLKRFIPEVWHPP----------------------------------DDVAARLRAAGFGA------------------VGAGATAEET--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RRMLHRAFDTLA----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Herpesvirus_4----------------------------------------------------------------------------------------------------------------
--------------------------------------------------------------------------------------------------------MSGGLFYNPFLRPNKGLLKKPDKEYLRLIPKCFQTPGAAGVVDVRGPQPPLCFYQDSLTVVGGDEDGKGMWWRQRAQEGTARPEADTHGSPLDFHVYDILE----------------TVYTH----EKCAVI---P--------------SDKQGYVVPC-----GIV---IKLLGRRKADG------ASVCVN------VFG--------QQAYFY----ASAPQGL-----------------------------------DVEFAVLSALK-------------ASTFDRRTPCRVSVE--KVTRRSIMG-YGN--------HAGDY-H---KITL-SH---PNSVCH-----VATWLQDK----------------------------HGCRIFEANVDATRRFVLDND-------FVTFG-----------------------------------------------------------------------------------------------------------------------------------------WYS-CRRAIPR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LQHRDSYAELEYDCE-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VGDLSVRREDSSWP----------------------------------------------------------------------------------------------------------------------------------------------------------------SYQALA----------------------------------------------------------------------------------------------------------------------------FDIECL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GEE----GFPTA----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TNEADL---------------------------------------------------------------------------------------------------------------------------------------------------------ILQISCVLWSTGEEA--------------------GRYRRILLTLG---TCEDIEGVE---------------------------------------VYEFPSELDMLYAF-----------------FQLIR-DLSVE----------------------IVTGYNVANFDWPYILDR------------------------------------------------------------------------------------------------------------------------
ARHIYSINPASLGKIRAGGV-------------------------------------------------------------CEVRRPHDAGKG-FLRA---NT------------KVRITGLIPI--D-MYAVC-RDKLSL-----S--DYKL---------DTVARHL-L----------------------GAK---------------------------------------------------------------------------------------------------KEDVHYKE--IPRLFAAG-----------PE-------GRRRLGMYCVQDSALVMDLLN--HFV----------------------------IHVEVAEI-AKIAHIPCRRVLDDGQQIRVFSCLLAA--------------------------AQKENFI----LP----------------MPSASDR------------------------------DG------------------------------------------YQGATVIQPL-SGFY-----------------------------------------------------------------NS-PVLVVDFASLYPSII-----QAHNLCYSTMI----------------------------------------T----PG--EEHRLAGL-----RPGEDYESFRLTG----------------------------------------------------------------------------------------------------------------------GVYHF---VKKH-------------------VHES--FLASLLTSWLAKRKAIK-----KLLAA------------------CED--PRQ-RTILDKQQLAIKCTCNAV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YGFTGV-ANGLFPCLSIAETVTLQGRTMLERA-KAFVEA-----------------------------------------------------------------LSPANLQALAPSPDAWAPLNPEGQL-RVIYGD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TDSLFIE----------------------CRG-FSESET---LRFADALAAHTTRSLF---VAP-------------ISLEAEKTF-SCLML-------IT-KKRYV-------GVLTDGK--------TLMKGVELVRKTACKFVQTRCRRVLDLVLA---DARVKEAASLLSHRPFQESFTQGLPVGFLPVIDILNQAYTDLR--EGRVPMGELCF------STELSRKLSAYKS-TQMPHLAV--YQKFV----ERN-EEL-P--QI---------------------------------------------------------------------------------------------------------HDRIQY---VFV----------------------------------EPKG-GVK-------------------GARKTEMAEDPAYAERHG---------------------------VPVAVDHYFD-----------------KLLQ--GAANILQC----------------------------------------------------------------------------------------------L----------------------------------------------------------------FDNNSGAALSVLQN------------------FTARPPF--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Entomopoxvirus-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSVFNNKIFKSTLSTDEYIDSDHAIHYIKKRTYDESIFKELTNDIENIRIHIINWY-----QYNYSK---L--------------ER-------------YIV---CKCKNIDT---------DELIFF------IFD--------FYHYFL-----------------CS-----------------------KELVNNNNDLKDLIN-----------IIDEYKIGEYEILENLKILDVDLIPKDY-YNFEE------TDINI-AKYRNLYL-FK---TIFKIQ-----LESEFNHS-------------------------FLDYRWFYVLNNIDPSACYNIDIT-------SDNCK-----------------------------------------------------------------------------------------------------------------------------------------IFVTNIHFKFK----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TYYVSNPKKLFMN------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KIDPLPC----------------------------------------------------------------------------------------------------------------------------------------------------------------------KISRLS----------------------------------------------------------------------------------------------------------------------------FDIECK----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
---------------------------------------------------------------------------QTGSFP------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DPKYMP---------------------------------------------------------------------------------------------------------------------------------------------------------ISHICVECFYD------------------------DPKKNKILILT---NCNLYEKNAKKNKKVYDMNECEKILNMNSSV-----------------IKIYTSEKNILIIF-----------------QCLLFHEFD------------------------YILSFNGHEFDIPYINTR------------------------------------------------------------------------------------------------------------------------MDIYNLLKLRMLNPFGFPN--------------------------------------------------------------LNVIKGDASSRY-THIE---YS------------------SILF--D-LYVYT-KKTYVL-----P--EYKL---------ETVCKTK-F----------------------NINAIAELIENTNNVKIIPKDTKNKLKIFYSVI--------RTANYCFINDIAYQINKNDIIDNMQKLYDKDAINQSIGVPFIVKNCNITGNIVVALS----KDDIDIGDKSTYENYTIE--------------------KANEIGNYCIHDTVLCNKLFE--TDL----------------------------IHEVITGY-SSQYLLPQNQVFNFTSSNTATGQLLYT--------------------------LLQEKQM----------------------FKKYITE-----------------------------KDE------------------------------------------YEGAYVFDPKVKKKY-----------------------------------------------------------------ITEPIILEDYTSLYPTIM-----RQINASPEK------------------------------------------I----IK--VITSNDNIMNAKIDNYIFNTYNYPEYMYIDITNSNK--L---------------------------------------------------------------------------------------------------------TTFII---TDCR--------------------KDG--IIPLMLKQGMEKRSFYK-----KKMND---------------AKKAND--DIL-YNVYNSMQYTTKIFINSI--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YGLMAS-ETFMFNSKYCAQFCTALGRKCIKYT-ADILNN-----------------------------------------SYNING-----------IFTVNNVINIFTKTHIQTKYNSNIQECFT--L-EIVYGD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TDSVFII--------------------
VHFKN-KSLNDT-YMLRLCKDIGIFISNTISNTGIFPKL-----------FNLEFGGVK-KWMLF-------IE-KKKYI---------SYDIINYDTLEAKIESKGTSLIKRDYSNFHKHHYKTIIEIIQKSIENKNNNSKNVV---------------------IKYIDELIKNLVDNLDKLNYMDFAV------TKRYSG---KYVSIDNIIELTV--NKFNA----KYP-DYK-I--RK---------------------------------------------------------------------------------------------------------GDRFLYIYGIYM----------------------------------KPID-KSW------------------NISYIKDISKKMIIIPSNLNNF------------------------NISEIRICIE----------------SYVIK--LITDVSQL----------------------------------------------------------------------------------------------L----------------------------------------------------------------DDKEI---------------------------TEKLSKYKKK------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Fowlpoxvirus------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDIRC----------------VNWFE----NKGETK---Y-----------------------------------IYLKAINR-ES------NVIFIR------FNY--------YYHYVY------------------------------------------DASKELEYKPNECID------------------LGPFKIINIDEKLSTDIRYV-------------EPRNYYTS--ELVL-VK---DLKRNR-----EKQYLQEY--------------------------LDITWFYLLNNITPDGCYKIDIE-----------------------------------------------------------------------------------------------------------------------------------------------------HLTPIKKDCYH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CDDVSKVF------------------------
IQEIPIFEV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KFTYLL----------------------------------------------------------------------------------------------------------------------------FDIECQ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FDK----KFP------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SVFVNP---------------------------------------------------------------------------------------------------------------------------------------------------------ISHISCWII--------------------------DKVTEYKFTLI---NTDILPDKEPSILHHKDFSPKD--------------------------RITYCTEIVMLLIM-----------------KKILEHRFD------------------------FVITFNGNNFDIRYISGR------------------------------------------------------------------------------------------------------------------------LEILEKSFIYFSLPDATETVK------------------------------------------------------------LKIFERFVTGGTFTNKT---YH------------INNNNGVMFF--D-LYAFI-QKTERL-----D--SYKL---------DSISKNI-F----------------------NCN------------VAIKEIDDTILTLEATVK--------DNSKDKLSIFSRVLETGNYITIGDNNVSKIVYKDINQDSFIIKVISNRDYEIGSVHNISFGKDDVDLKD--MYKNYNLE--------------------IALDMERYCIHDACLCKYIWD--YYR----------------------------VPSKINAA-SSTYLLPQSLALEYRASTLIKGPLLKL--------------------------LLEERVI----------------------YTRKITK----------------------------VRYP------------------------------------------YIGGKVFLPS-QKTF-----------------------------------------------------------------EN-NVMIFDYNSLYPNVC-----IYGNLSPEK------------------------------------------L----VC--ILLNSNKL-----ESEINMRTIKSKYPYPEYVCVSC--ESRLSDY---------------------------------------------------------------------------------------------------YSEII---VYDR-------------------REKG--IIPKLLEMFIGKRKEYK-----NLLKT------------------AST--TIE-STLYDSLQYIYKIIANSV-----------------------------------------------------------------------------------
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YGLMGF-SNSTLYSYSSAKTCTTIGRNMITYL-DSIMNG--------------------------------------AVWENDKLI-----------LADFPRNIFSGETMFNKELEVPNMNESFK--F-RSVYGD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TDSIFSE----------------------IST-KDIEKT---AKIAKHLEHIINTKIL---HAN-------------FKIEFEAIY-TQLIL-------QS-KKKYT-------TIKYLANYKPGDKPIRVNKGTSETRRDVALFHKHMIQRYKDMLMKLLMESKGQQEITRLIL------------------QSLETDMISEF---THNREFEKYLL------SRKHHN---NYKS-ATHSNFEL--VKRYN----LEN--TEKI--EI---------------------------------------------------------------------------------------------------------GERYYY---IYI----------------------------------CDIS-LPW----------------------QKKLCNILSYEVIADSKFY-----------------------LPKDKRIFYE----------------IYFKR--IASEVVNL----------------------------------------------------------------------------------------------L-----------------------------------------------------------------TDKTQCMLFFSRL------------------FGTKPVFSSD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Yokapoxvirus------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDVRC----------------INWFE----SRGDER---F-----------------------------------LYLKARCK-
NG------DTVFIR-----------------FPYYYY-----------------------------------------YVVTDDIYHSLSPEAF-------------------RSKSLGEMK--IINIEEIVS-YSIDIDD----RNISI-S---NMWIIEE---PKKRNI-----SKIYMDEF--------------------------LNITWFFIINEISPDGCYSLDDT-----------------------------------------------------------------------------------------------------------------------------------------------------YLTKINSSCYH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CDDIKRCF------------------------IKEIDRFNI--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PRSYLF----------------------------------------------------------------------------------------------------------------------------LDIECH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FDK----KFP------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SVFINP---------------------------------------------------------------------------------------------------------------------------------------------------------ISHISYCYIDL------------------------SGIRRLFTLIN---EEMLSTHEIEDAVNNRGCIHITSLKDMDYN------------------KEYVICPEIILLQI-----------------SKHLL-ELTFD----------------------FVVTFNGHNFDLRYISNR------------------------------------------------------------------------------------------------------------------------LELLTGEKIIFKSPDKKEHVM------------------------------------------------------------LSVYERNQSSHK-GVGGIANTT----------FHVNNNNGTIFF--D-LYTFI-QKSEKL-----D--SYKL---------DSISKNA-F----------------------NCISRVEDVGSGTITFIGDNTTDEKGKAELFGRILSTGNYITIDDDIICKVIEKEIYDKGFKVILS
CKYILNDTTYKLSFG---------------------KDDVDLSE--MYRNYNLD--------------------IALDMARYCIHDACLCQYLWE--YYG----------------------------VETKTDAG-AATYVLPQSMIFEYKASTLIKGPLLKS--------------------------LLDTKTI----------------------LVRYDTK----------------------------QKLP------------------------------------------YEGGKVFVPK-QKMF-----------------------------------------------------------------TN-NVLIFDYNSLYPNVC-----IFGNLSPET------------------------------------------L----VG--VLVSTNKL-----EKEINDQLLLHKYPPPRYISVYC--EPRYPNL---------------------------------------------------------------------------------------------------ISEIA---IFDR-------------------SIEG--IIPRLLRTFLTERLKYK-----KMMKH------------------ATT--STE-KDIYDSMQYTYKIIANSV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YGLMGY-RNSALYSYASAKSCTSIGRKMIIYL-ESVLNG------------------------------------STLSNGIINFA-----------NPLINPFYKDTRDTNHKIKTLLPIEYNCN--F-RSVYGD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TDSVFTE----------------------IDT-KDVDLS---IEVAKELERIINEKVL---FDN-------------FKIEFEAVY-KNLIM-------QS-KKKYT-------TMKYSASSNSLSTPERINKGTSETRRDVSKFHKNMIKVYKTRISEMLSDGNMSASQVCCDIL-----------------KSLNIDLQTEFE--NRTSPLELFLL------SRTHHS---NYKS-VDNPNMLL--VTEYN----KNNTEKI----EL---------------------------------------------------------------------------------------------------------GERYYF---AYI----------------------------------CPASEPWT---------------------RKLVNIKTYETIIDRSFK-------------------------LSNDKRIFYE----------------VYFKR--LASEIVNL----------------------------------------------------------------------------------------------L----------------------------------------------------------------DNSSQMSISFFQRM------------------FGTKPIFYK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Variolavirus------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDVRC----------------INWFE----SHGENR---F-----------------------------------LYLKSRCR-NG------ETVFIR-----------------FPHYFY-----------------------------------------YVVTDEIYQSLAPPPF-------------------NARPMGKMRTIDIDETIS---YNLDIKD----RKCSV-A---DMWLIEE---PKKRNI-----QNATMDEF--------------------------LNISWFYISNGISPDGCYSLDDQ-----------------------------------------------------------------------------------------------------------------------------------------------------YLTKINNGCYH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CGDPRNCF-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AKEIPRFDI-------------------------------------------------------------------------------------------------------------------------------------------------------------------PRSYLF----------------------------------------------------------------------------------------------------------------------------LDIECH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FDKKFP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
---------------------------SVFINP---------------------------------------------------------------------------------------------------------------------------------------------------------ISHTSYCYIDL------------------------SGKRLLFTLIN---EEMLTEQEIQEAVDRGCLRIQS--------------------------LMEMDYERELVLCSEIVLLQI----------AKQLL-ELTFD----------------------YIVTFNGHNFDLRYITNR------------------------------------------------------------------------------------------------------------------------LELLTGEKIIFRSPDKKEAVH------------------------------------------------------------LCIYERNQSSHK-GVGGMANTT----------FHVNNNNGTIFF--D-LYSFI-QKSEKL-----D--SYKL---------DSISKNA-F----------------------SCM--------------GKVLNRGVREMTFIGD--------DTTDAKGKAAVFAKVLTTGNYVTVD-DIICKVIHKDIWENGFKVVLSCPTLTNDTYKLSFGKDDVDLAQ--MYKDYNLN--------------------IALDMARYCIHDACLCQYLWE--YYG----------------------------VETKTDAG-ASTYVLPQSMVFGYKASTVIKGPLLKL--------------------------LLETKTI----------------------LVRSETK----------------------------QKFP------------------------------------------YEGGKVFAPK-QKMF-----------------------------------------------------------------SN-NVLIFDYNSLYPNVC-----IFGNLSPET------------------------------------------L----VG--VVVSSNRL-----EEEINNQLLLQKYPPPRYITVHC--EPRLPNL---------------------------------------------------------------------------------------------------ISEIA---IFDR-------------------SIEG--TIPRLLRTFLAERARYK-----KMLKQ------------------ATS--STE-KAIYDSMQYTYKIIANSV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YGLMGF-RNSALYSYASAKSCTSIGRRMILYL-ESVLNG------------------------------------AELSNGMLRFA-----------NPLSNPFYMDDRDINPIVKTSLPIDYRFR--F-RSVYGD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TDSVFTE----------------------IDS-QDVDKS---IEIAKELERLINSRVL---FNN-------------FKIEFEAVY-KNLIM-------QS-KKKYT-------
TMKYSASSNSKSVPERINKGTSETRRDVSKFHKNMIKIYKTRLSEMLSEGRMNSNQVCIDIL-----------------RSLETDLRSEFD--SRSSPLELFML------SRMHHL---NYKS-ADNPNMYL--VTEYN----KNNPETI----EL---------------------------------------------------------------------------------------------------------GERYYF---AYI----------------------------------CPANVPWT---------------------KKLVNIKTYETIIDRSFK-------------------------LGSDQRIFYE----------------VYFKR--LTSEIVNL---------------------------------------------------------------------------------------------------------------------------------------------------------------LDNKVLCISFFERM------------------FGSRPTFYEA------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Vacciniavirus------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDVRC----------------INWFE----SHGENR---F-----------------------------------LYLKSRCR-NG------ETVFIR-----------------FPHYFY-----------------------------------------YVVTDEIYQSLSPPPF-------------------NARPLGKMRTIDIDETIS---YNLDIKD----RKCSV-A---DMWLIEE---PKKRSI-----QNATMDEF--------------------------LNISWFYISNGISPDGCYSLDEQ-----------------------------------------------------------------------------------------------------------------------------------------------------YLTKINNGCYH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CDDPRNCF-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
AKKIPRFDI-------------------------------------------------------------------------------------------------------------------------------------------------------------------PRSYLF----------------------------------------------------------------------------------------------------------------------------LDIECH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FDKKFP------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SVFINP---------------------------------------------------------------------------------------------------------------------------------------------------------ISHTSYCYIDL------------------------SGKRLLFTLIN---EEMLTEQEIQEAVDRGCLRIQS--------------------------LMEMDYERELVLCSEIVLLRI----------AKQLL-ELTFD----------------------YVVTFNGHNFDLRYITNR------------------------------------------------------------------------------------------------------------------------LELLTGEKIIFRSPDKKEAVY------------------------------------------------------------LCIYERNQSSHK-GVGGMANTT----------FHVNNNNGTIFF--D-LYSFI-QKSEKL-----D--SYKL---------DSISKNA-F----------------------SCM--------------GKVLNRGVREMTFIGD--------DTTDAKGKAAAFAKVLTTGNYVTVDEDIICKVIRKDIWENGFKVVLLCPTLPNDTYKLSFGKDDVDLAQ--MYKDYNLN--------------------IALDMARYCIHDACLCQYLWE--YYG----------------------------VETKTDAG-ASTYVLPQSMVFEYRASTVIKGPLLKL--------------------------LLETKTI----------------------LVRSETK----------------------------QKFP------------------------------------------YEGGKVFAPK-QKMF-----------------------------------------------------------------SN-NVLIFDYNSLYPNVC-----IFGNLSPET------------------------------------------L----VG--VVVSTNRL-----EEEINNQLLLQKYPPPRYITVHC--EPRLPNL---------------------------------------------------------------------------------------------------ISEIA---IFDR-------------------SIEG--TIPRLLRTFLAERARYK-----KMLKQ------------------ATS--STE-KAIYDSMQYTYKIVANSV----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YGLMGF-RNSALYSYASAKSCTSIGRRMILYL-ESVLNG------------------------------------AELSNGMLRFA-----------NPLSNPFYMDDRDINPIVKTSLPIDYRFR--F-RSVYGD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TDSVFTE----------------------IDS-QDVDKS---IEIAKELERLINNRVL---FNN-------------FKIEFEAVY-KNLIM-------QS-KKKYT-------TMKYSASSNSKSVPERINKGTSETRRDVSKFHKNMIKTYKTRLSEMLSEGRMNSNQVCIDIL-----------------RSLETDLRSEFD--SRSSPLELFML------SRMHHS---NYKS-ADNPNMYL--VTEYN----KNNPETI----EL---------------------------------------------------------------------------------------------------------GERYYF---AYI----------------------------------CPANVPWT---------------------KKLVNIKTYETIIDRSFK-------------------------LGSDQRIFYE----------------VYFKR--LTSEIVNL---------------------------------------------------------------------------------------------------------------------------------------------------------------LDNKVLCISFFERM------------------FGSKPTFYEA------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Monkeypoxvirus------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDVRC----------------INWFE----SHGENR---F-----------------------------------LYLKSRCR-NG------ETVFIR-----------------FPHYFY-----------------------------------------YVVTDEIYQSLSPPPF-------------------NARPMGKMRTIDIDETIS---YNLDIKD----RKCSV-A---
DMWLIEE---PKKRSI-----QNATMDEF--------------------------LNISWFYISNGISPDGCYSLDEQ-----------------------------------------------------------------------------------------------------------------------------------------------------YLTKINNGCYH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CDDPRNCF-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AKEIPRFDI-------------------------------------------------------------------------------------------------------------------------------------------------------------------PRSYLF----------------------------------------------------------------------------------------------------------------------------LDIECH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FDKKFP------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SVFINP---------------------------------------------------------------------------------------------------------------------------------------------------------ISHTSYCYIDL------------------------SGKRLLFTLIN---EEMLTEQEIQEAVDRGCLRIQS--------------------------LMEMDYERELVLCSEIVLLRI----------AKQLL-ELTFD----------------------YVVTFNGHNFDLRYITNR------------------------------------------------------------------------------------------------------------------------LELLTGEKIIFRSPDKKEAVH------------------------------------------------------------LCIYERNQSSHK-GVCGMANTT----------FHVNNNNGTIFF--D-LYSFI-QKSEKL-----D--SYKL---------DSISKNA-F----------------------SCM--------------GKVLNRGVREMTFIGD--------DTTDAKGKADTFAKVLTTGNYVTVDEDIICKVIRKDIWENGFKVVLSCPTLPNDTYKLSFGKDDIDLAQ--MYKDYNLN--------------------IALDMARYCIHDACLCQYLWE--YYG----------------------------VEXKXDAG-
ASTYVLPQSMVFEYRASTVIKGPLLKL--------------------------LLETKTI----------------------LVRSETK----------------------------QKFP------------------------------------------YEGGKXFAPK-QKMF-----------------------------------------------------------------SN-NVLIFDYNSLYPNVC-----IFGNLSPET------------------------------------------L----VG--VVVSTNRL-----EEEINNQLLLQKYPPPRYITVHCEPRL--------------------------------------------------------------------------------------------------------PNLISEIAIFDR-------------------SIEG--TIPRLLRTFLAERARYK-----KMLKQ------------------ATS--STE-KAIYDSMQYTYKIVANSV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YGLMGF-RNSALYSYASAKSCTSIGRRMILYL-ESVLNG------------------------------------AELSNGMLRFA-----------NTLSNPFYMDDRDINPIVKTSLPIDYRFR--F-RSVYGD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------XDSVFTE----------------------IDS-QDVDKS---IEIAKELERLINSRVL---FNN-------------FKIEFEAVY-KNLIM-------QS-KKKYT-------TMKYSASSNSKSVPERINKGTSETRRDVSKFHKNMIKTYKTRLSEMLSEGRMNSNQVCIDIL-----------------RSLETDLRSEFD--SRSSPLELFML------SRMHHS---NYKS-ADNPNMYL--VTEYN----KNNPETI----EL---------------------------------------------------------------------------------------------------------GERYYF---AYI----------------------------------CPANVPWT---------------------KKLVNIKTYETIIDRSFK-------------------------LGSNQRIFYE----------------VYFKR--LTSEIVNL---------------------------------------------------------------------------------------------------------------------------------------------------------------LDNKVLCISFFQRM------------------FGSRPTFYEA----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Culex_nucleopolyhedrovirus------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MFMKK----------------CSWEE----VRNYVD---S--------------TRCEYT---------VPA---NAVFLIT----------KIRCIS------DER--------PNSYLQ--------------------------------------------PSEVHLYLRNPFI-------------GIKVILYSVPIVGYAFCNCERK----------------GEVDC-----KLCVPCT---PVLAPDHINPVIKRVRQTT--------------------------NGVRNYLCDSNMSDVERFMNYYK-------IFESS-----------------------------------------------------------------------------------------------------------------------------------------YVA-FTTHLTP------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QNGTVRGLNIAQVYVPT---------------------LALPEEVNGFQI---------------------------------------------------------------------------------------------------------------------------------------------------------------------AYNPRGPKKMTDDQ----------------------------------------------------------------------------------------------------------------------------------------------------------LVPLKPIKMTM--------------------------------------------------------------------------------------------------------------------------ASYDIETY--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NSSKHHRMADP------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TIEGDT------------------------------------------------------------------------------------------------------
---------------------------------------------------VFSISIHYYESAE------------------------VQEYFQLYL---DPNAVIDSEYRPTVDTFKEGTTIR------------------------VILCKDEAELMDNF-----------------ITLID-ALNPD----------------------LVVDFNGHGYDIPYMITR--------------------------------------------------------------------------------------------------------------------------QSGDPKLNTFKFMRY----------------------------------------------------------------GVTDPTINFVKNDSYVD---VN------------RITSSSYQML--D-MFKFA-RKWHP------GETSFKL---------DDLASKY-L----------------------GAK---------------------------------------------------------------------------------------------------KISYDFKV--MKVDYEQG--------------------RPHLIIEYNMVDAILVTLLSL--HLQ----------------------------APERLFTK-ARMTGYTMNYALDEGAVKAYNTLFFYR--------------------------GLEMNQI----YTFTDSLRNKLSPEVLGGRRQRYDAEILNISFKRAIEEERKRSPERQDELDDLERKSLFRISTAQQTWGDQGNTK------------------------IGGGLVLPTV-PGLH-----------------------------------------------------------------EH--LAIMDFNSLYPSIM-----LAERVCPNN---------------------------------------------------IAVES-------------------------------------------------------------------------------------------------------------------------------------------NGDLL---LVPM-------------------PKEN--LTSSIIKEALKNRKFHR-----SEAAKY-----------------DKD--SYE-YMMHDAAQGAYKITANSV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YGFFAL----RFP--PLGNFITKTGRGKVRSA-VNYTTE--------------------------------------------------------------------------------YWNEQYGLCA-FFVYGD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TDSIMFK--------------------FMQPT-SGVTVD---PNAFPGLIEHFSAGLAKTVGVG-------------YNMALELIV-RSSVF-------THRKKSYV-------FHIADNI--------YKYRGL-LVGRNLTRAIVRCYKRWIEYTMKLCEEGALSYSLA----------------------TDILLEDLRKIQ--EEDFSVDS------------LSRTISYSGKSGSLIANSL--VGQHE----AAF-GYT-P--TV---------------------------------------------------------------------------------------------------------GDRLKFISATNI----------------------------------VYEH-
GKLLKGKLTANMTPTRASLLYNFALKLKLERNQLEVQHREKFNNMRTYNSYFLKAERLLDSITELIQTPSKARKLFE----------DLKKIVDSVIPYNLLTDLFDP---------------------------------------------------------------------------------------------------------DIHRVNWSIYGRQGHTLVSVLGPTF-----------------------------DAHFPESPNEVERI------------------RNELDEKFER--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CSYPTTARLYNTKGEVVVS------------------------------------------------------------------------------------------------------KTRGYRHISAKQLVQEFVACRNELEVEDADEI----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QFDRSEVAQCNGERAMAKVRAPRRSGPPVVQHIPAKLAAPSHDDEEFTEDEIRTWLGLKM---------------------------------------------------------Cydia_granulovirus----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLLSKRKAEGVEYEPAVKAIKLSQETLMGDN----------------TNFKV----CLDVNE---L--------------IPAKL----------VSA---GMCFNNTHEFL------ITRLRY------DNG--------FLLLFL------------------------------------------TGVNNVQLYYKTPCT-----------------------IHSYRRCYHMRTPCVN------------KCETYKS---MVVTGLK---AYQCNR-----INVFKVDR------------------------------ARCNNDDAMLLDRFCTDVNRVQMQLGLCEGD-----------------------------------------------------------------------------------------------------------------------------------------YVRFKNVVRVN---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EEGLAIGPLGNVEK-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
LKVEDVRN----------------------------------------------------------------------------------------------------------------------------------------------------------------------PTKVIV--------------------------------------------------------------------------------------------------------------------------ASFDLETF------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TNLNSFS------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NPKVDP---------------------------------------------------------------------------------------------------------------------------------------------------------IITISLVVKTH------------------------DDTPKQYCFINTQGRNFTLDDPVEERVDGEII------------------------------VLPYHNERDMIVAF-----------------FTLLC-KSNPD----------------------TILDYNGDKFDIPYWTQR------------------------------------------------------------------------------------------------------------------------AIILDI------DPKFLRRYN------------------------------------------------------------LSPVEMNTVEVN-TKFG---YK---------LN-NHFMKYFNHL--D-VYQFIKGSIDAS-----KLENLKL---------DTAASYY-L----------------------KVG---------------------------------------------------------------------------------------------------KVELPVRE--MMRLYNNK--------------------QFGKIVKYNVRDSLLPLNMFLKCKMDNKQYADASLLYLTNDDSHLTIYHRLNLALFHRAISN-INEAGRPDPYFFNRSDLSKIMGGNKRFAADEKEDKEV-----------ENEGELVDFTVLGRPPVP----------------TSQIPAD--------------------AIPLCDLKTRIK------------------------------------------YIGGKVLSPK-PGYY-----------------------------------------------------------------RK--TFTLDFSQLYTSIM-----IFFTTCLSN---------------------------------------------------LFVGANKK----------------------------------------------------------------------------------------------------------------------------------------LYLQI--------------------------NQNA--ITTKFLKEMANNRVLYK-----QEMKKY-----------------EPD--SFE-YQMYDSWQNAAKLVCNSQ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YGWFGL------CCKPLANFITAQGRSKLEEA-QRIITE----------------------------------------------------------------------LSENEAIKTKWNLSKMK--L-EVVYGD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TDSNFVS-------------------I-DLER-EEFERMGGDVGLRRLIMEDIMK-PLNDTWKGA------------FKMELENIM-DCMLI-------KG-KKSYM-------CLKENGT--------LYKRGFN-VKKDSPLFLRQAFDAVIFEILN---NHSLDCI------------------------LNHLVSSLKKKRDEFCVANCEEYSF------SQTLNETKNGGTGVVTIANELA--IQLRN----DANTKYI-P--SS---------------------------------------------------------------------------------------------------------GDRIPY---LLI----------------------------------DKLASTVK------------------------GRAKPTQLINADDTINWSKHLGIVNTFLNDIMSMIGNDTLFVYAFNEICE----------------YFQKD--QCFDVLYP----------------------------------------------------------------------------------------------N-------------IKTLTNSR-IKDILCKE----------------------------------LNVKKKKDLTDDKL------------------NDILRNNEQK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F--IHKYE-----------------------------------------------------------------------------------------------------FTLNKRRPAYTINIERFSTDCPKCNERGV----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SAVQKTTSLELVVEKQSASRKRPSKQN----------------------------------------------------------Neodiprion_nucleopolyhedrovirus-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MGMVIKKSIFEKLIYDSKFLST----------------IRPQI----NGKPSP---A--------------
NDSEFH---------ISK---NVVWRITR---------ITAIED------DEH--------VHKLVF------------------------------------------ALSTTLSETIPTTIC----------------AYIMKPRLYMWQRCFCNNIPNSVCFR---------NCIKM-----KYLM------APGVKG-----YENTINVY------------------------KVYRKQTRVLDDFLTTPMRLCHQYG-------ITEGC-----------------------------------------------------------------------------------------------------------------------------------------YVT-FRHDMYI---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KEIPVLCQLNDFII------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VKENVQEI---------------------------------------------------------------------------------------------------------------------------------------------------------------------KTSVLA----------------------------------------------------------------------------------------------------------------------------FDIEVR----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SPSGRFCNA------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KKIDDE---------------------------------------------------------------------------------------------------------------------------------------------------------IISISLVMKRV------------------------DDVTLRFCLIY---RQNAVFSTLQDCDTNGTL------------------------------VILHDSEKEMIETF-----------------LNCIE-LMNPD----------------------FITGYNSSNFDIPYIRDR------------------------------------------------------------------------------------------------------------------------MKILNMG--------------------------------------------------------------------------NLFVRRFGFQLEVKFGN---FF----------Q-RFRKVPAINI--P-LYAYH-DTILSVNNLRLD--NYRL---------DTVARFL-L----------------------NEN---------------------------------------------------------------------------------------------------
KIDLPFWE--LNRLWECG--------------------EIDNIIKYNVYDSELTLKVFL--KLD----------------------------VTNVSYSM-CEIMKIS-TESLNEGIMKKLTGLVFDY-------------------------AINNVNVIDNETIPDPYFLLITDFYVCK--TKQDTKV------------------VENTMSFHKLKRQPVPYKVIEKYHPVKLCNADGKFV--------------------YTGGDVMQPR-RGVF-----------------------------------------------------------------EN--VGIFDFEGMYATRM-----IKDKICETN---------------------------------------------------IVITENGD----------------------------------------------------------------------------------------------------------------------------------------VYRLT--------------------------HQIG--VVDKIVADLKQRRTDLK-----KILKTL-----------------KSD--TFE-YKMLHIFQNTVKEITNSM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YGWHAT------NCKILAAEITRLARNKLYDA-QNKINN------------------------------------------------------------------------------------HISNNY-TVIYGD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TDSCFVH----------------------VKNIDNPVYH---LKLLEKELNDSWNGD--------------------AVIELENFC-VKIIL-------YQ-KKNYC-------FLTDKG---------VFKDTIVTKRRNKPLMARQSLEIFLKHFLQ---TSSFEESMFKF--------------------IDYIKKITEVLD-------------------VKLYTSSV-QYSEGKNSHASYC--VDLLK----KHANQTI-P--HD---------------------------------------------------------------------------------------------------------GERIDI---LYI----------------------------------KNNSTVIK------------------------EKCLPLEMFDASK---------------------------YDIDFTKFCE----------------DHIKP--FMVMFGTL----------------------------------------------------------------------------------------------L-----NDKQKFIVENYEKIFQLITKSRTRC----------------------------------YMVKGTKFDIKYTD------------------NKSITQYFH----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Gulladenovirus--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLITRDLTDAWTWISSRAPVRKCLSCG----------------RYWNT----GHSCNE---L-----------------------------RSA---FYFHAVQK-NG------RDMWQH------------------VPF---------------------------------------------RCPAQPANLRQLFV--------------------TYDIETYTQHEARGK----------------RMHPFLL---CFALSGD---DALASE-----ARRLALQD------------------------------ETLRETGGGYY-------------------------------------------------------------------------------------------------------------------------------------------------------------WLDFEPGAVAR----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RFRAFR----------------------------------------------------------------------------------------------------------------------------TRLQQH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FARDL-------------------------------------------------------------------------------------------------------
--------------------------------------------------VRRFAEHN---------------------------GEFCQQTMRDG---GYASPYDIPYEL------------------------------------FEQPAQALTLPEDF-----------------YVVNV----------------------------VVLGHNITKFDELLLATE----------------------------------------------------------------------------------------------------------------------LVERRDIFPTAGKCTRTFMPRVGRLLFNDVHFAMPNPL---------------------------------------------YLRRDPTRTQRW-ARGIVLPSD------------ARHVAVRFLV-RD-TLQLTSGAKLKK-----AAAAYALELAKGECPYEAVNDMVAL----------------------GSF---------------------------------------------------------------------------------------------------ESDADGFP--VARYWESEAVRREQKALWEQNHPGTPYDLTRACLEYCMLDVKVTEELAV--TL-----------------------------YRSYDTYY-KRELGMRGDYNIFERPTIPSNTHAFWKQLAFTAFAEKNGAEADARGKRKGKRKDVPHNYVAMLYAP----------------YRPMFTY----------------------------IRQA------------------------------------------LRGGRCYPNV-LGPY-----------------------------------------------------------------RE-RVYVFDICGMYASALTHPMPHGMPLDPAH------------------------------------------S----AK--HVDELNAMLARERPLSYFDERVKPSILKIDAYPPPV--DMLDPLP-----------------------------------------------------------------------------------PLCSRR----------GGKLV---WTNE-------------------ALHE--EVVTVLDVLTLHNRGWTVTVLHDEMNIVFPEWSTICADYVARNIAAKE--KAD-KEKNEVMRSISKMLSNAL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YGAFAT--NMDTSRVVFEQDLTDRDRKEIYEG-TQIVK--------------------------------------------------------------------------------------------HVTLLNDRSFSGVVVTPQSAPFSAERMRRH------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FDALGDHEDDEYDRSPEDTDEEEEEGEVDARVADRSPDP---YDVIKGERKRTETALTEDEPLPLTE----------VDLDLEEAL----------------RDPAL-------LYPSDDHAHYASANETRFKSMVLLDAAPEALTVLHLEKLDQLVEN---KRYATQIACFVLGWS----------------RAVRCGWCEILHGPDRGVHQHDRQP------QSLYGDTDSMFVTESGYRRMKERGAHRIK----GPQ-TRL-I--
YD---------------------------------------------------------------------------------------------------------EKRPAL---YWA----------------------------------CECD-VKC------------------------ERCKADAYASES----------------------------VFLAPKLYGL----------------RDAVCTNPECGHVGP--------------------------------------------------------------------------------------------------------GKIRSKGHRQAELIYDTLLKC----------------------------------WQRYEDQLYAG---------------------FSDLPELHTS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RTIFKTTLLNKVSRYEPFTIHTEPLT-----------------------------------------------------------------------------------------------------RVLRPWRDPTLYAHGGFLYPCDTAHPNPRTAHE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RRRVPDIGHEDPLAPLDIDPLSFLSVEECDCLLDSIGESCGEPDEAKEEPEAGSRRR------------------------------------------------Murineadenovirus_2---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDPSAGTRGDLGTPVHPGDPTTRHPGGPATNPGSPTLAAAPPTLGAAARSPSPTSGGGGTATKKMKAKKQKPQV----------------LGWRA----ARYLAG---R--------------SD-----------------------GATD-RA------LRVAYH------PEG--------LRPFRR----LLEL---------LH-----------------------LDPDQHHLRLQELLT------------------QQSQRPLRLDE-LVEVLGLEP-WG---------GPVDLIRSHLSCISPPH---PLLCPGAG---AAPGLPSR--------------------------PKLIFLLVSGKTSVHGLYLV----------RHQKP-----------------------------------------------------------------------------------------------------------------------------------------FVELLRCDDCG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
VVYRQCHVCNPHRASY------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YYHQIKPSKDWWEPVRFQPIGS-------------------------------------------------------------------------------------------------------------------------------------------------------PAGILR------------------------------------------------------------------------------------------------------------------------LFITYDIETY-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TWHGGRGKELLPYLLVFHLHGD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DTLLQP---------------------------------------------------------------------------------------------------------------------------------------------------------VARLLATDPELGRDWTRYPE-----------------DALTYYRLD---RTPHAIGNKFHQFRNQVQQCLAWCFWDRVRKQSPRLAAMEDEGHEFTADELQTNVDSYLRELNERRLRAKRRRRSDDDGLQDEEGEEGPE--------PTCLLEGRPHFWEVYVVGHNISGFDEIVMAAA----------------------------------------------------------------------------------------------------------------------VIDNRASVPAAFRVSRTFMPRQGKVLFNDIRYSLPN-----------------------------------------------PRYRPRVSFEEW-EQGI---ER----------VSDRRHQGLVFLVRD-TYQLT-HTSLRQ-----AAAAYNLSVAKGHCPYEAVNDHFRL----------------------GTYE--------------------------------------------------------------------------------------------------SDDWGFPS--LRYWASEQEHREAREEFLTRSPRPVRYDIEAEALRYCALDVQVTAELVQ--RLAESYSR-----------------------FVTEHVGLDVRSNFNVFQRPTISSNSHAIFRQVWYR-------------------ETQIRRPTFHHRLL----AP----------------SHQMYDY----------------------------VRLS------------------------------------------IRGGRCYPTF-LGVL-----------------------------------------------------------------EE-PIFVYDICGMYASALTHPFPVGFPLAGPRLQ----------------------------------------LAIERWR--RRLRDRAA------ISYFDPELLPGILSIDADAPDP--EQLDVLP-----------------------------------------------------------------------------------
PFSSRR----------GGRLC---WTNE-------------------DLRG--EVATTIDIVTLHNRGWKVRVLDDARSTIFPETACVARSYVTLNIQAKE--QAD-REKNQTMRSIAKLLSNSL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YGSFAT-KLDNRRALFAADFDGEYGDEDERGD-VAVI---------------------------------------------------------------------------------------------GATFLV------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PDAMSEE---------------------ILPQFRHTYYS---PVQCSNVVRLPNGG---------------------LSYCYDGTL-PPENA------DLPRPPPPF-------IPREHDPP--VQQPEYQPMGFFQAEPDDITIL--TVQKQTDLVEN---KRYPTHLASFVLAWT----------------RAFVSEWANFLYESDRGLRLERRLL------KSVYGDTDSLFLTAEGRRWMEDRGRHRIK----KNRLGGL-V--FD---------------------------------------------------------------------------------------------------------PEKPAL---TWL----------------------------------VECE-TVC------------------------SVCGADAYSPST----------------------------VFLAPKVYAL----------------REVIC--TADPSHRG----------------------------------------------------------------------------------------------R---------GKLRAKGHAASQLNYELLATC----------------------------------YQRHELEEDPEARF------------------VTSRVALKRT-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LASLQANAIPFSVLETRLTRVLQPW--KDRTL-----------------------------------------------------------------------------------------------------APLTPDEPHLLVPYSNSQPNPRIVETQLMPNEL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ANAPPTDQAMPMPPIPPTCSSILWPSDT------------------------------------------------------Humanadenovirus_37----------------------------------------------------------------------------------------------------------------
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MQCVDTTTNSPVE----------------IKYHL----HLKHAL---T--------------R--------------LYE---VNLRTLPPDLD------LRDTMD------SSQ--------LRALVF----ALRP-----------------------------------RRAEIWTWLPRGLV----------------------SLSVLEEPQGESHAGEH-ENHQPGP----PLLKFLLKGRAVYLVDE---VQPVQR------CEYCGRF-----------------------------YKHQHECSVRRRDFYFHHIN-------SHSTN-----------------------------------------------------------------------------------------------------------------------------------------WWQEIQFFPIG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SHPRTERLFVT----------------------------------------------------------------------------------------------------------------------------YDVETY-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TWMGSFGKQLVPFMLVM-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KFSGDPE--------------------------------------------------------------------------------------------------------------------------------------------------------LVALARDLAVRLRWDRW------------------ERDPLTFYCVT---PEKMAVGQQFRLFRDELQTLMAREL-----------------------WASFMQANPHLQEW-----------------ALEQHGLQCPEDLTYEELKKLPHIKGRPRFMELYIVGHNINGFDEIVLAAQ----------------------------------------------------------------------------------------------------------------------VINNRASVPGPFRITRNFMPRAGKILFNDVTFALPN-----------------------------------------------
PLSKKRTDFELW-EHGGCDDSD-----------FKYQFLKVMVR--D-TFALT-HTSLRK-----AAQAYALPVEKGCCPYKAVNHFYML----------------------GSY---------------------------------------------------------------------------------------------------RADDRGFP--LREYWKDDEEYALNRALWEKKEEAGYD-IIRETLDYCAMDVLVTAELVA--KLQDSYAH-----------------------FIRDSVRL-PHAHFNIFQRPTISSNSHAIFRQIVFR-------------------AEQPQRTNLGPAFL----AP----------------SHELYDY----------------------------VRAS------------------------------------------IRGGRCYPTY-IGIL-----------------------------------------------------------------SE-PIYVYDICGMYASALTHPMPWGPPLNPYERA----------------------------------------LAAREWQ--MALDDASS-----KIDYFDKELCPGIFTIDADPPDE--HLLDVLP-----------------------------------------------------------------------------------PFCSRK----------GGRLC---WTNE-------------------PLRG--EVATSVDLVTLHNRGWRVRIVPDERTTVFPEWKCVAREYVQLNIAAKE--RAD-RDKNQTMRSIAKLLSNAL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YGSFAT-KLDNKKIVFSDQMDESLLKSIAAGQ-ANIK---------------------------------------------------------------------------------------------SSSFLE------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TDNLSAE------------------VMPALER-EYLPQQ---LALVDSDAEESEDEHR---PAP-----------------------------------------FY-------TPPSGTPG----HVAYTYKPITFLDAEEGDMCLHTVEKVDPLVDN---DRYPSHVASFVLAWT----------------RAFVSEWSEFLYEEDRGTPLQDRPI------KSVYGDTDSLFVTERGHRLMETRGKKRIK----KNG-GKL-V--FD---------------------------------------------------------------------------------------------------------PEQPEL---TWL----------------------------------VECE-TVC------------------------AHCGADAFAPES----------------------------VFLAPKLYAL----------------QSLLC--PACGRSSK----------------------------------------------------------------------------------------------G---KLRAKGHAAEALNY-----KLMVNCYL----------------------------------ADAQGEDRARFSTS------------------RMSLKRTLAS----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
AQPGAHPFTVTETTLTRTLRPW--KDMTL-----------------------------------------------------------------------------------------------------AALDAHRLVPYSRSRPNPRNEEVCWIEMP-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Chimpanzeeadenovirus_Y25------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MALVQTHGSRGLHPEASDPGRQPSRRRSRQSSPGAVPEPTRARRRRAPAAPASGPRAASAARRAS----------------SPPLLTMEEAPPPSP---Q--------------PPKKKRGTVVTPQGHGT----LQAIDVAT-NGAVE---IKYHLD------LPR--------ALEKLLQVNRAPPLPTDLTPQRLRT-----------------------LDSSGLRALVLALRP-----------ARAEVWTCLPRGLVSMT--TIEAEEGQADHHDVVQHEMQAPRLHFPL---KFLVKGT---QVQLVQ-----HVHPVQRC-----------------------EHCGRLYKHKHECSARRRHFYFHHIN-------SHSSN-----------------------------------------------------------------------------------------------------------------------------------------WWQEIQFFPIG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SHPRT-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ERLFLT----------------------------------------------------------------------------------------------------------------------------YDVETY-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TWMGSFGKQLVPFMLVMK------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LSGDDR---------------------------------------------------------------------------------------------------------------------------------------------------------LVELALDLALQLKWDRW------------------HGDPRTFYCVT---PEKMAVGQQFRQYRDRLQTALAVDL-----------------------WTSFLRANPHLADW-----------------ALEQHGLSDPDELTYEELKKLPHVKGRPRFVELYIVGHNINGFDEIVLAAQ----------------------------------------------------------------------------------------------------------------------VINNRAEVPQPFRITRNFMPRAGKILFNDVTFALPN-----------------------------------------------PAYKKRTDFQLW-EQGGCD-DI----------DFKHQFLKVMVR--D-TFALT-HTSLRK-----AAQAYALPVEKGCCAYKAVNQFYML----------------------GSY---------------------------------------------------------------------------------------------------RADQDGFP--LEEYWKDREEFLLNRELWKQKGQLKYD-IIQETLDYCALDVLVTAELVA--KLQDSYAH-----------------------FIRDSVGL-PHAHFNIFQRPTISSNSHAIFRQIVYR-------------------AEKPSRTNLGPGLL----AP----------------SHELYDY----------------------------VRAS------------------------------------------IRGGRCYPTY-IGIL-----------------------------------------------------------------EE-PLYVYDICGMYASALTHPMPWGTPLSPYERA----------------------------------------LAVREWQ--ASLDDLAT-----SISYFDPDLLPGIFTIDADPPDE--VMLDPLP-----------------------------------------------------------------------------------PFCSRK----------GGRLC---WTNE-------------------PLRG--EVATSVDLITLHNRGWQVRIVPDEMTTVFPEWKCVAREYVQLNIAAKE--RAD-KEKNQTMRSIAKLLSNAL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YGSFAT-KLDNKKIVFSDQMDEGLLKGISAGT-VNIK---------------------------------------------------------------------------------------------SSSFLE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------TDNLSAE------------------VMPAFER-EYLPQQ---LALLDSDPEDSEDEQG---PAP-----------------------------------------FY-------TPPAGTPG----HVAYTYKPITFLDVDEGDMCLHTLEKVDPLVDN---DRYPSHVASFVLAWT----------------RAFVSEWAGFLYEEDRGTPLEDRPI------KSVYGDTDSLFVTQRGHELMETKGKKRIK----KNG-GKL-V--FD---------------------------------------------------------------------------------------------------------PDQPDL---TWL----------------------------------VECE-TVC------------------------AHCGADAYAPDS----------------------------VFLAPKLYAL----------------KSLLC--PACGQTSK----------------------------------------------------------------------------------------------G----KLRAKGH-AAEALNYEL-MVNC--YL----------------------------------ADAQGADRERFSTS------------------RMSLKRTLAS----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AQPGAHPFTVTETTLTRTLRPW--KDRTL-----------------------------------------------------------------------------------------------------AALDAHRLVPYSRSRPNPRNEEVCWIEMP-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
