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Lessons and Curriculum Part One

Graduate Level LessonI. Neurosciences and Physiology

A. Medical Neuroscience is a multidisciplinary course that is organized jointly by Neurologyand Neuropathology, with assistance from the departments and/or divisions of Cell

Biology, Physiology, Psychiatry, Neuroradiology, Internal Medicine, and Neuroscience.Emphasis is placed on applying basic anatomical and physiological principles toproblems in neuropathology and clinical neurology.

B. The Medical Physiology course examines the physiological function and regulation ofmajor organ systems and their components in the human body. Topics includemembranes and transport mechanisms; skeletal, cardiac and smooth muscle; and thecardiovascular, respiratory, renal, gastrointestinal, and endocrine systems.1. Instruction is composed of lectures, problem-solving and case-study sessions, and

clinical correlation sessions taught by practicing physicians. The course emphasizesmechanistic and integrative functions of normal physiology and explores abnormalfunction that occurs in many human diseases.

C. Chapters for entire lessons

2. Chapter 4 pgs. 49-62 "Smaller than Sand"3. Chapter 5 pgs. 65-72 "Making Blood"4. Chapter 6 pgs. 75-80 "Where the Blood Flows"

D. Background reading5. Go to following link below. Read each section and write a paragraph summary on

each section. Sections 11.2-12.7. Interactive activities on each section may helpwith understanding(does not work on portable device, try a computer)

II. http://nba.uth.tmc.edu/neuroscience/m/s4/chapter11.html6. Go to following link blow. Read Lactate Physiology in health and disease. Take

notes on key points - will be discussed in class.III. http://ceaccp.oxfordjournals.org/content/6/3/128.full

(1) Key points:

(a) Blood lactate concentrations reflect the balance between lactateproduction and clearance.

(b) Glycolysis, gluconeogenesis and pyruvate conversion to and from lactateare linked with NAD+ and NADH.

(c) Failure of oxidative mechanisms can affect both production and clearanceof lactate.

(d) Lactate concentrations >5 mmol litre 1 with severe metabolic acidosispredicts high mortality.

(e) Impaired lactate clearance, rather than hypoxic tissue production oflactate, is the cause of hyperlactaemia in stable septic patients.

II. PapersE. Case study

7. Student will choose ONE of the THREEtopics to discuss, study, and evaluate. Thecase study will have to include research on the internal and external human bodywith an anonymous patient (consent forms will be given out). APA format, 25 pages,10 background resources.a) Topics:

(2) Memory : The human memory is made up of four types of memory: working,episodic, semantic and remote. Each type uses a different network in thebrain, and therefore, one type can be affected by disease or injury whileanother type functions normally. The student will need to discuss how specific

http://nba.uth.tmc.edu/neuroscience/m/s4/chapter11.htmlhttp://nba.uth.tmc.edu/neuroscience/m/s4/chapter11.htmlhttp://ceaccp.oxfordjournals.org/content/6/3/128.fullhttp://ceaccp.oxfordjournals.org/content/6/3/128.fullhttp://ceaccp.oxfordjournals.org/content/6/3/128.fullhttp://nba.uth.tmc.edu/neuroscience/m/s4/chapter11.html

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memories that have occurred in TWO peoples life are affected by injury ordisease one patient will have a specific disease or injury and person twowill be constant(healthy). The student will have to look at the working,episodic, semantic, and remote memories

(3) Art and Creativity : Creativity combines elements of emotion, planning andsensory perception. Furthermore, creative expression can involve linguistic,

graphic and/or motor skills as well. The student will need evaluate howspecific activities induced creativity in the brain.

(4) Behavior : Neurodegenerative disease can lead to changes in a loved onessocial interactions. These changes may occur because of structural andneurochemical changes in the brain that affect a persons ability to processand act on information. The student will need to study how behavior canchange with disease. Student will chose a patient will a neurological disorderthat is known to change emotions and memories of love ones and how thataffects those around the patient as well as the patient. The student will needto discuss how the brain is affected as well as which parts and why does thisoccur.

III. Exam

F. Exam part 18. Student will be evaluated on what was learned about neuroscience and their clinical

ability with neurological diseases. Student will need to be able to spot out specificdiseases of the spinal cord, and brain that are affected by diseases, in blood as wella healthy brain and spinal cavity.

G. Exam part 29. Student will be evaluated on their ability to understand the components of blood

including blood lactate levels, and what level of lactate blood solutions do to specifictissues. Student will also have to recite blood flow and how the failure of inadequateblood flow can affect each body system, and the body as a whole.