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PROTEINS: PRIMARY
STRUCTURELesson 4
SUCCESS CRITERIA Describe the structure of an amino acid Describe the formation and breakage of
peptide bonds Explain the term primary structure
STARTER Draw the structure of a protein and label
it in as much detail as you can
TASK Use the diagram of the amino acid to
make a model using molymods
AMINO ACID
R Group
Acid GroupAmino
Group
EXAMPLES OF AMINO ACIDS WITH DIFFERENT R GROUPS
Valine
Phenylalanine
FORMATION OF A DIPEPTIDE
+ H20
Condensa
tion
Reactio
n
Hydro
lysis
Reactio
n
Peptide Bond
TASK Make another model of an amino acid to
make a model using of peptide bond formation
PROTEINS The function of each protein is
determined by its structure A protein’s structure is firstly
determined by its amino acid sequence
KEY TERM: PRIMARY STRUCTURE The specific sequence of amino acids
that make up a protein
MAKING A POLYPEPTIDE CHAIN DNA strands code for protein structure 3 bases code for a specific amino acid,
this is known as a codon or triplet code
TASK Use the look up table to create a DNA strand that
will code for a 10 amino acid protein, it needs to start with Methionine and end with a stop code
Swap with the person next to you Convert their DNA strand into a polypeptide
chain
HYDROLYSIS OF PEPTIDE BONDS The covalent bond that forms the
peptide bond is strong, it must be broken apart by an enzyme
Enzymes that breakdown proteins are called proteases
Examples of protease activity other than digestion:Hormone regulationAgeing
P101 in book
PAST PAPER QUESTION Jan 2010 Q4a
PROTEIN (BIURET TEST)1. Draw a results table2. Add sample to a test tube.3. Add biuret reagent4. Identify which sample contains protein5. What colour is a positive test? What
colour is a negative test?
Practical Skills: Qualitative• Drawing Results Table
PROTEIN (BIURET TEST)1. Add sample to a test tube.2. Add biuret reagent3. Positive result shown by lilac
PEER ASSESS RESULTS TABLEMark Complete?
Appropriate column and row headings
Ruled rows and columns
Separate conclusions and observation columns
All tests and results recorded
Correct conclusions for all test results
SUCCESS CRITERIA Describe the structure of an amino acid Describe the formation and breakage of
peptide bonds Explain the term primary structure
PLENARY Draw the structure of a protein and label
it in as much detail as you can
HOMEWORK Complete the first part of the summary
table