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17° RIUNIONE ANNUALE del REGISTRO DIALISI DEL LAZIO. L’EMODIALISI nel LAZIO in ETA’ PEDIATRICA. Stefano Picca Dipartimento di Nefrourologia , Unità di Dialisi Ospedale “Bambino Gesù” , Ist . di Ricerca Scientifica ROMA, Italia. - PowerPoint PPT Presentation
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Stefano PiccaDipartimento di Nefrourologia, Unit di DialisiOspedale Bambino Ges , Ist. di Ricerca ScientificaROMA, Italia.LEMODIALISI nel LAZIO in ETA PEDIATRICA 17 RIUNIONE ANNUALE del REGISTRO DIALISI DEL LAZIO
*
Demographics of CKD due to CAKUT:Insights from the ERA/EDTA Registry
Elke Whl, M.D.
Center for Pediatrics and Adolescent Medicine, University of Heidelberg, Germany
*
large longitudinal database of patients receiving RRT throughout Europecomplete population-based information from birth to adulthood available from 12 countries covering 150 million people
*
Spectrum of Primary Renal DiagnosesESCAPE and 4C-Study
*
Nefropatie di base allingresso (coorte 1995-2010)Et media (DS) allingresso per nefropatia CAKUT: 10,3 (4,9) Glomerulopathies: 8,6 (6,2) Hereditary: 11,0 (5,2) Other: 7,7 (6,2)
*
Incidence rates of RRT in the ERA-EDTA Registry
by age per million populationDiabetic or hypertensive GNunknownGNCAKUT
Diagramm3
0.93770140372.85621691930.57124338391.35805030880.31256713460.64669062320.22634171810.03233453120.97003593490.43112708220.0970035935
1.02750372181.93848640290.79446164050.32837747810.10592821870.26482054680.38134158750.0847425750.64616213430.73090470930.0741497531
2.01282889713.77151273151.13856988120.40663210040.12198963010.23381345770.31513987780.5184559280.80309839841.15890148620.1728186427
4.83730118614.69613480911.02580900641.20461975060.15057746880.39526585570.17881074421.00698682281.53400796372.64451679630.7340651605
8.91717779544.09242459210.65478793471.49050411460.11200319940.53416910470.2153907681.68004799043.63579616394.63520932751.3440383924
11.09599740473.52836752011.07766881271.06968608070.17562010280.35124020560.19158556671.83602834758.27809302786.01897988721.6125118531
13.11960670963.24313581791.71057998990.82045918070.17802416180.50311176170.13158307611.772501437514.33481511877.11322629272.0279274088
15.62442299492.81239613914.99200314690.77340893820.24217855640.41404720940.24217855641.984301720420.0383224919.25747062452.4764710447
18.920755992.575643101510.17174608970.90760756910.45789210690.44971546220.36794901452.305813824227.522586284512.32220366333.7530799479
22.6713382022.287212402417.34614902090.77695383130.56743819140.55870837310.55870837312.540377133940.296841409417.17155265435.3950277277
26.17023034272.115810933222.05145172610.73348112350.80870995670.45137299910.53600543643.084382160461.1704449823.05763736988.3409968789
31.79968770712.12414416922.39722601770.66639817071.25990904140.35402402820.84341018484.060863852697.502382347432.705572720311.214231716
35.37114675932.038649617820.7320300120.93294135051.77374034550.36856942241.12874385625.1714897085141.784049692947.69518682217.2306204988
41.94027572422.373977871218.86209740270.68754550372.46478576790.38917670020.98591430725.9803486263202.125405523767.275678906825.2835129559
43.94287808742.66229826419.6232321480.79270678653.61952910050.44870195461.21149527747.2988851282255.057147727999.357569480831.7082714586
41.76966081142.289262632115.93101618550.52540453854.14694296470.43158229951.08833797267.0366679264272.1595509472121.368448395434.2075883464
28.85607272021.806979505610.84187703360.25019716232.86336752430.33359621640.86179022574.8649448228213.0011841832113.72851011424.2691247444
10.50115013850.75008215273.637898440801.500164305500.18752053821.275139659792.972682833164.732089782111.4012487218
GN
Cakut
CKD
Hered.NP
IRF
HUS
Metabolic
Vasculitis
Misc
unknown
PN_other
All_g_abs
0-45-910-1415-1920-2425-2930-3435-3940-4445-4950-5454-5960-6464-6970-7475-7980-8485+Total
GN8797198514103513901695200023142597278330543071323329382226103828030550
Cakut26518337149947544241936031526222520417718317812265204765
CKD53751121097613522163912441987234521511800145413128493909715049
Hered.NP12631401281731341069911189786481535328901403
IRF2910121613222331566586121154190242221103401434
HUS60252342624465535564483432303023120702
Metabolic21363119252417314564578198768158315800
Vasculitis3851107195230229254282291328390449461488375175344350
Misc9061791634221037185225653366461665059364123101558117053145047662247999709
unknown40691142815387549191185150719672452314141415186664364684091172641222
PN_other9717781562022623174596188871077149619492120182387330412654
Total783602104819563170441458087534975412620157941968123809283963113826697144494985212638
FrequencyMissing=292
99999278006894403551983690171062575971160681131252703971291959461280047271222995531145499211063422059603867986822178770858076685952653292269359716312666374616762749318638259_RBREAK_391810233
All_g_abs
8726553126296021390409
971837531102536861697
19837111240122331517911417
51449910912816421910716328178
103547576173136225195422538156
13904421351342244242301037754202
16954192211062365172291852919262
20003606399931533125425651185317
2314315124411156554528233661507459
259726219878965646429146161967618
278322523457886485732865052452887
30542042151641213481390936431411077
307117718008115432984491231041411496
323318314545319030764611558151861949
293817813125324230814881705366432120
22261228492822123583751450464681823
1038653909103123117576624091873
2802097040053424791726304
GN
Cakut
CKD
Hered.NP
IRF
HUS
Metabolic
Vasculitis
Misc
unknown
PN_other
all_g_pmp
872655312629602139
97183753110253687
198371112401223315117
51449910912816421910778
103547576173136225195156
1390442135134224424230202
1695419221106236517229262
200036063999315331254317
23143151244111565545282459
2597262198789656464291618
2783225234578864857328887
305420421516412134813901077
307117718008115432984491496
323318314545319030764611949
293817813125324230814882120
22261228492822123583751823
10386539091031231175873
28020970400534304
GN
Cakut
CKD
Hered.NP
IRF
HUS
Metabolic
Vasculitis
PN_other
all_d_abs
000000000
000000000
000000000
000000000
000000000
000000000
000000000
000000000
000000000
000000000
000000000
000000000
000000000
000000000
000000000
000000000
000000000
000000000
GN
Cakut
CKD
Hered.NP
IRF
HUS
Metabolic
Vasculitis
PN_other
all_d_pmp
0-45-910-1415-1920-2425-2930-3435-3940-4445-4950-5454-5960-6464-6970-7475-7980-8485+Total
GN0.93770140371.02750372182.01282889714.83730118618.917177795411.095997404713.119606709615.624422994918.9207559922.67133820226.170230342731.799687707135.371146759341.940275724243.942878087441.769660811428.856072720210.5011501385
Cakut2.85621691931.93848640293.77151273154.69613480914.09242459213.52836752013.24313581792.81239613912.57564310152.28721240242.11581093322.1241441692.03864961782.37397787122.6622982642.28926263211.80697950560.7500821527
CKD0.57124338390.79446164051.13856988121.02580900640.65478793471.07766881271.71057998994.992003146910.171746089717.346149020922.051451726122.397226017720.73203001218.862097402719.62323214815.931016185510.84187703363.6378984408
Hered.NP1.35805030880.32837747810.40663210041.20461975061.49050411461.06968608070.82045918070.77340893820.90760756910.77695383130.73348112350.66639817070.93294135050.68754550370.79270678650.52540453850.25019716230
IRF0.31256713460.10592821870.12198963010.15057746880.11200319940.17562010280.17802416180.24217855640.45789210690.56743819140.80870995671.25990904141.77374034552.46478576793.61952910054.14694296472.86336752431.5001643055
HUS0.64669062320.26482054680.23381345770.39526585570.53416910470.35124020560.50311176170.41404720940.44971546220.55870837310.45137299910.35402402820.36856942240.38917670020.44870195460.43158229950.33359621640
Metabolic0.22634171810.38134158750.31513987780.17881074420.2153907680.19158556670.13158307610.24217855640.36794901450.55870837310.53600543640.84341018481.12874385620.98591430721.21149527741.08833797260.86179022570.1875205382
Vasculitis0.03233453120.0847425750.5184559281.00698682281.68004799041.83602834751.77250143751.98430172042.30581382422.54037713393.08438216044.06086385265.17148970855.98034862637.29888512827.03666792644.86494482281.2751396597
Misc0.97003593490.64616213430.80309839841.53400796373.63579616398.278093027814.334815118720.03832249127.522586284540.296841409461.1704449897.5023823474141.7840496929202.1254055237255.0571477279272.1595509472213.001184183292.9726828331
unknown0.43112708220.73090470931.15890148622.64451679634.63520932756.01897988727.11322629279.257470624512.322203663317.171552654323.057637369832.705572720347.69518682267.275678906899.3575694808121.3684483954113.72851011464.7320897821
PN_other0.09700359350.07414975310.17281864270.73406516051.34403839241.61251185312.02792740882.47647104473.75307994795.39502772778.340996878911.21423171617.230620498825.283512955931.708271458634.207588346424.269124744411.4012487218
Total8.43931263346.37687876810.653761031318.408095564227.311549383135.235778808944.954970955558.857201421979.7549930538110.1703073195148.5205239068204.9278499551274.227168086368.3687192897465.7227154138500.9544630198401.6776442525186.9579765724
all_d_pmp
0000000000
0000000000
0000000000
0000000000
0000000000
0000000000
0000000000
0000000000
0000000000
0000000000
0000000000
0000000000
0000000000
0000000000
0000000000
0000000000
0000000000
0000000000
GN
Cakut
CKD
Hered.NP
IRF
HUS
Metabolic
Vasculitis
unknown
PN_other
cyst_a
0.93770140372.85621691930.57124338391.35805030880.31256713460.64669062320.22634171810.03233453120.97003593490.43112708220.0970035935
1.02750372181.93848640290.79446164050.32837747810.10592821870.26482054680.38134158750.0847425750.64616213430.73090470930.0741497531
2.01282889713.77151273151.13856988120.40663210040.12198963010.23381345770.31513987780.5184559280.80309839841.15890148620.1728186427
4.83730118614.69613480911.02580900641.20461975060.15057746880.39526585570.17881074421.00698682281.53400796372.64451679630.7340651605
8.91717779544.09242459210.65478793471.49050411460.11200319940.53416910470.2153907681.68004799043.63579616394.63520932751.3440383924
11.09599740473.52836752011.07766881271.06968608070.17562010280.35124020560.19158556671.83602834758.27809302786.01897988721.6125118531
13.11960670963.24313581791.71057998990.82045918070.17802416180.50311176170.13158307611.772501437514.33481511877.11322629272.0279274088
15.62442299492.81239613914.99200314690.77340893820.24217855640.41404720940.24217855641.984301720420.0383224919.25747062452.4764710447
18.920755992.575643101510.17174608970.90760756910.45789210690.44971546220.36794901452.305813824227.522586284512.32220366333.7530799479
22.6713382022.287212402417.34614902090.77695383130.56743819140.55870837310.55870837312.540377133940.296841409417.17155265435.3950277277
26.17023034272.115810933222.05145172610.73348112350.80870995670.45137299910.53600543643.084382160461.1704449823.05763736988.3409968789
31.79968770712.12414416922.39722601770.66639817071.25990904140.35402402820.84341018484.060863852697.502382347432.705572720311.214231716
35.37114675932.038649617820.7320300120.93294135051.77374034550.36856942241.12874385625.1714897085141.784049692947.69518682217.2306204988
41.94027572422.373977871218.86209740270.68754550372.46478576790.38917670020.98591430725.9803486263202.125405523767.275678906825.2835129559
43.94287808742.66229826419.6232321480.79270678653.61952910050.44870195461.21149527747.2988851282255.057147727999.357569480831.7082714586
41.76966081142.289262632115.93101618550.52540453854.14694296470.43158229951.08833797267.0366679264272.1595509472121.368448395434.2075883464
28.85607272021.806979505610.84187703360.25019716232.86336752430.33359621640.86179022574.8649448228213.0011841832113.72851011424.2691247444
10.50115013850.75008215273.637898440801.500164305500.18752053821.275139659792.972682833164.732089782111.4012487218
GN
Cakut
CKD
Hered.NP
IRF
HUS
Metabolic
Vasculitis
Misc
unknown
PN_other
cyst_pmp
000000000
000000000
000000000
000000000
000000000
000000000
000000000
000000000
000000000
000000000
000000000
000000000
000000000
000000000
000000000
000000000
000000000
000000000
GN
Cakut
CKD
Hered.NP
IRF
HUS
Metabolic
Vasculitis
PN_other
CAKUT_a
000000000
000000000
000000000
000000000
000000000
000000000
000000000
000000000
000000000
000000000
000000000
000000000
000000000
000000000
000000000
000000000
000000000
000000000
GN
Cakut
CKD
Hered.NP
IRF
HUS
Metabolic
Vasculitis
PN_other
CAKUT_pmp
PRD(PRD)agedm
0-45-910-1415-1920-2425-2930-3435-3940-4445-4950-5454-5960-6464-6970-7475-7980-8485+
-929192853568299132152206248255255250269226125312495
0Chronic renal failure; aetiology uncertain3150862284826728201053135517612204288638864936637462423966169538727
10Glomerulonephritis; histologically NOT examined491614128742855469679196810601252130014401379107855614712106
11Focal segmental glomerulosclerosis with nephrotic syndrome in children52526968443929464234253127312517111643
12IgA nephropathy (proven by immunofluorescence, not code 76 and not 85)10158024535846250755558755656642838825017860205256
13Dense deposit disease; membrano-proliferative GN; type II (proven by immunofluorescence and/or electron microscopy)05699301619182921182217161051251
14Membranous nephropathy1117253757749812413417520922823617469151665
15Membrano-proliferative GN; type I (proven by immunofluorescence and/or electron microscopy - not code 84 or 89)38103653649493108103125108131110106823621272
16Crescentic (extracapillary) glomerulonephritis (type I, II, III)38223752584750627699146170217237224111321651
17Focal segmental glomerulosclerosis with nephrotic syndrome in adults1210237810512813217818521319219017714111948241946
19Glomerulonephritis; histologically examined, not given above22114679193242289363434461516520526555467287115305156
20Pyelonephritis - cause not specified54650104140158193234314432490643807790575243675255
21Pyelonephritis associated with neurogenic bladder14183049504648393434372627181722482
22Pyelonephritis due to congenital obstructive uropathy with/without vesico-ureteric reflux8046981431341301189286544533344041383191252
23Pyelonephritis due to acquired obstructive uropathy2361529323850801061782764406687557734121754038
24Pyelonephritis due to vesico-ureteric reflux without obstruction15208718719918619915212913110285817369431661780
25Pyelonephritis due to urolithiasis0038816334583131194227293334415350159412340
29Pyelonephritis due to other cause2025151433296267838412014016012559211021
30Interstitial nephritis (not pyelonephritis) due to other cause, or unspecified (not mentioned above)31312183142447074106132162183214213170101271615
31Nephropathy (interstitial) due to analgesic drugs0001162011355910815822225624018867161388
32Nephropathy (interstitial) due to cis-platinum000033433713181020181000112
33Nephropathy (interstitial) due to cyclosporin A000214912184046638011273361710523
34Lead induced nephropathy (interstitial)00000102321101400015
39Drug induced nephropathy (interstitial) not mentioned above12491415173640629816216117814211752181128
40Cystic kidney disease - type unspecified5851091321458413314818719516015713076151401
41Polycystic kidneys; adult type (dominant)4517166416155211221814213319171569126311246912967812817
42Polycystic kidneys; infantile (recessive)37212019141510911122215147101120249
43Medullary cystic disease; including nephronophthisis54183622832243017112217975862409
49Cystic kidney disease - other specified type2031191153101720151317169102173
50Hereditary/Familial nephropathy - type unspecified9581725232719373428243128241050354
51Hereditary nephritis with nerve deafness (Alports Syndrome)041988118866458534232253418191440678
52Cystinosis22624643176755323111107
53Primary oxalosis189659031561731442185
54Fabrys disease0001144851113711101058
59Hereditary nephropathy - other specified type117221323302515222113181516710400371
60Renal hypoplasia (congenital) - type unspecified47386556323925443325273921293719121589
61Oligomeganephronic hypoplasia046103211000241310038
63Congenital renal dysplasia with or without urinary tract malformation11365917054323022281717810107442584
66Syndrome of agenesis of abdominal muscles (Prune Belly)96634301010013300040
70Renal vascular disease - type unspecified034762427578317330255285014412117215912634369504
71Renal vascular disease due to malignant hypertension020135180136197206252269217229275271217116442575
72Renal vascular disease due to hypertension113104094144228394589974145920382960372939572706109120418
73Renal vascular disease due to polyarteritis126391013143232356779112152117669759
74Wegeners granulomatosis10131827262546558411614821321324420089191537
75Cholesterolembolia00020237242128611091361578117630
76Glomerulonephritis related to liver cirrhosis00010022331391210681070
78Cryoglobulinaemic glomerulonephritis01011022467882885164
79Renal vascular disease - due to other cause (not given above and not code 84-88)52366614183374104159262421530469255502417
80Diabetes glomerulosclerosis or diabetic nephropathy - Type I302610956211441493171718351877209521652131181210803696718467
81Diabetes glomerulosclerosis or diabetic nephropathy - Type II2002284590254644148827083925495351323688154531224798
82Myelomatosis/light chain deposit disease00010521550116199281456580662572268943301
83Amyloid003931478090103205240361487572471355100213175
84Lupus erythematosus10205912715616416815913011110779644229721425
85Henoch-Schoenlein purpura06122727292111171318182322201493290
86Goodpastures Syndrome01334492919202830344668708157278604
87Systemic sclerosis (scleroderma)000059615193248505550301541339
88Haemolytic Uraemic Syndrome (including Moschcowitz Syndrome)60252342624465535564483432303023120702
89Multi-system disease - other (not mentioned above)2128211029325365908185139132121649944
90Tubular necrosis (irreversible) or cortical necrosis (different from 88)2910121613222331566586121154190242221103401434
91Tuberculosis0000127520183044636874482110411
92Gout010043161011184048373425132253
93Nephrocalcinosis and hypercalcaemic nephropathy1017714891929202243353928141297
94Balkan nephropathy00002123238109151342074
95Kidney tumour21626651217285399172221299334205101331620
96Traumatic or surgical loss of kidney4143965102023427380100105944013632
98Other identified renal disorders00000002010132330015
99Chronic renal failure; aetiology uncertain482940587499841321532042133214024825234832681363749
FR080000001017254666114204266280342374236842064
TotalTotal783602104819563170441458087534975412620157941968123809283963113826697144494985212638
FrequencyMissing=292
99999278006894403551983690171062575971160681131252703971291959461280047271222995531145499211063422059603867986822178770858076685952653292269359716312666374616762749318638259_RBREAK_391810233
0-45-910-1415-1920-2425-2930-3435-3940-4445-4950-5454-5960-6464-6970-7475-7980-8485+
-920.09700359350.20126361560.28464247030.49878786550.48247532030.65458401960.7662779141.03121191771.24285000451.79834257592.33209382862.65518021132.9370375853.24313916834.02336085964.24076520373.47496058771.1626273368
0Chronic renal failure; aetiology uncertain0.33412348870.52964109370.87425901592.14572893084.15273400715.36439586766.34694837878.226258706811.079353658815.373210078420.725543541230.05039250944.758149236964.032539738595.3342086212117.1276831917110.253549526363.5694624454
10Glomerulonephritis; histologically NOT examined0.04311270820.09533539690.16265284021.3269639442.47268601673.41660927284.28806024615.43729920226.46772601048.45046414319.967820396413.036414213914.973132786418.680481609320.625333179920.228074732615.45662469415.5131038227
11Focal segmental glomerulosclerosis with nephrotic syndrome in children0.56046520680.55082673740.70144037320.63995424250.37908775170.31132654590.22446524750.35936172890.34341908020.29681382320.23509010370.32278661390.31098045020.40214925690.37391829550.31899561270.30579653170.0375041076
12IgA nephropathy (proven by immunofluorescence, not code 76 and not 85)0.010778177100.15248703770.75288734412.11082952652.85781803663.57596359873.96079122924.53803784555.12440335955.22840390615.89345882194.92961602515.03335198923.7391829553.34007170911.66798108210.7500821527
13Dense deposit disease; membrano-proliferative GN; type II (proven by immunofluorescence and/or electron microscopy)00.05296410940.06099481510.08469982620.07754067650.23948195840.12384289520.14843201850.14717960580.25316473160.19747568710.18742448550.25339147790.22053346340.23930770910.1876444780.13899842350.0375041076
14Membranous nephropathy0.01077817710.01059282190.01016580250.06587764260.2153907680.2953610820.44119031410.57810365080.80131118711.08249747291.26008295581.82218249792.40721904032.95774292153.52978870953.26501391791.91817824440.5625616146
15Membrano-proliferative GN; type I (proven by immunofluorescence and/or electron microscopy - not code 84 or 89)0.03233453120.0847425750.10165802510.33879930490.45662842820.51089484450.72757700930.72653566930.88307763480.89917128791.17545051841.1245469131.50883107311.4269812341.58541357291.53868471991.00078864930.0750082153
16Crescentic (extracapillary) glomerulonephritis (type I, II, III)0.03233453120.0847425750.22364765520.34821039670.44801279750.46299845290.36378850460.39061057490.50695197550.6634661930.93095681061.52022082691.95802505672.81504479813.54474544144.20323630813.08576500191.2001314444
17Focal segmental glomerulosclerosis with nephrotic syndrome in adults0.01077817710.02118564370.10165802510.21645511140.67201919620.83818685430.99074316161.03121191771.45544276851.6150163912.00296768341.9991945122.18838094572.29614253112.10889918662.23296928871.33438486570.9000985833
19Glomerulonephritis; histologically examined, not given above0.23711989520.11652104060.46762691550.74347625231.6628167291.93182113092.23691229442.83583277363.54866382874.02444624994.85225974015.41448513686.05835988137.19976895366.984793765.38539651973.19696374071.1251232291
20Pyelonephritis - cause not specified0.05389088530.04237128750.06099481510.47055459010.89602559491.11758247241.222948591.5077568191.91333487542.74116295554.06235699185.10211099437.405941832110.468853235211.815818137910.78955748726.75532338252.5127752117
21Pyelonephritis associated with neurogenic bladder0.01077817710.04237128750.18298444520.28233275410.42216590530.39913659730.35604832370.37498615190.31888914590.29681382320.3197225410.38526144240.29946265570.35025903020.26922117280.31899561270.05559936940.0750082153
22Pyelonephritis due to congenital obstructive uropathy with/without vesico-ureteric reflux0.86225416430.48726980620.99624864611.34578612761.15449451651.0377551530.91334135210.71872345780.70319144990.47141018980.42316218660.34361155680.39160501130.51890226690.61322600460.71304901650.86179022570.3375369687
23Pyelonephritis due to acquired obstructive uropathy0.02155635410.03177846560.06099481510.1411663770.24985329090.25544742230.29412687610.39061057490.65413158130.92536074291.67384153832.87384211115.06782955858.665667857611.292332524214.504918152411.4534700976.5632188365
24Pyelonephritis due to vesico-ureteric reflux without obstruction0.16167265580.21185643750.88442481841.75987416691.71451051331.48478814191.5402960091.18745614761.05478717491.14360620120.95916762310.88506007040.93294135050.94699663711.03201449560.80687125560.44479495520.2250246458
25Pyelonephritis due to urolithiasis000.03049740750.07528873440.06892504580.12772371110.25542597130.35154951740.67866151561.14360620121.82429920462.36363101163.37471377424.33283392886.20704370536.56755673144.42014986751.5376684131
29Pyelonephritis due to other cause0.021556354100.0203316050.0470554590.12923446080.11175824720.25542597130.22655413340.50695197550.58489782810.78049914420.8746475991.38213533411.81615793422.39307709122.34555597551.64018139740.7875862604
30Interstitial nephritis (not pyelonephritis) due to other cause, or unspecified (not mentioned above)0.03233453120.13770668440.12198963010.16939965240.26708455230.33527474170.34056796180.54685480480.60507171270.92536074291.24127574751.68682036952.10775638452.7761271283.18578387773.18995612672.80776815491.0126109062
31Nephropathy (interstitial) due to analgesic drugs0000.00941109180.00861563070.04789639170.1548036190.08593432650.28618256680.51505928141.01558924791.64517048392.55695036813.32097450833.58961563683.52771618711.8625788750.6000657222
32Nephropathy (interstitial) due to cis-platinum00000.02584689220.02394819580.03096072380.02343663450.02452993430.06110872830.12224685390.18742448550.11517794450.25945113350.26922117280.18764447800
33Nephropathy (interstitial) due to cyclosporin A0000.01882218360.12061883010.07184458750.09288217140.1406198070.32706579070.40157164320.59242706130.83299771331.28999297850.94699663710.53844234550.31899561270.02779968470
34Lead induced nephropathy (interstitial)000000.007982731900.0156244230.02452993430.01745963670.00940360410.010412471400.01297255670.0598269273000
39Drug induced nephropathy (interstitial) not mentioned above0.01077817710.02118564370.040663210.08469982620.12061883010.11974097920.13158307610.28123961390.32706579070.54124873640.92155320651.68682036951.85436490662.30911508782.12385591852.19544039311.44558360450.6750739375
40Cystic kidney disease - type unspecified0.05389088530.0847425750.05082901260.0941109180.07754067650.10377551530.16254379990.35154951740.68683816041.16106583781.39173341381.9471321552.2459699182.07560906772.34820689582.43937821452.11277603730.5625616146
41Polycystic kidneys; adult type (dominant)0.04311270820.05296410940.01016580250.06587764260.13785009150.51089484451.24616913294.31234074669.174195428215.835890449920.057887646819.960707706118.071419493816.384339078116.811366565812.96623343258.22870667172.9253203957
42Polycystic kidneys; infantile (recessive)0.3987925510.22244925940.20331605020.17881074420.12061883010.11974097920.07740180950.07030990350.08994309240.104757820.20687929120.15618707130.16124912230.09080789670.14956731820.20640892580.05559936940
43Medullary cystic disease; including nephronophthisis0.05389088530.43430569680.84376160840.58348769170.24123766020.25544742230.18576434280.23436634490.1390029610.09602800160.20687929120.17701201410.10366015010.09080789670.07478365910.15011558240.16679810820.0750082153
49Cystic kidney disease - other specified type0.021556354100.03049740750.10352200980.07754067650.08781005140.03870090470.02343663450.08176644770.14840691160.1880720830.15618707130.14973132790.22053346340.23930770910.16888003020.2779968470.0750082153
50Hereditary/Familial nephropathy - type unspecified0.09700359350.05296410940.08132642010.15998856060.2153907680.18360283480.20898488560.14843201850.30253585640.29681382320.26330091610.2498993140.3570516280.36323158680.35896156370.1876444780.13899842350
51Hereditary nephritis with nerve deafness (Alports Syndrome)00.04237128750.19315024770.82817607861.0166444250.68651494730.49537158080.45310826690.43336217260.36665236980.30091533270.26031178540.39160501130.23350602010.28417790460.26270226930.11119873880
52Cystinosis0.02155635410.27541336870.24397926030.05646655080.03446252290.02394819580.00774018090.05468548050.04905986860.06110872830.04701802070.05206235710.03455338340.02594511330.04487019550.01876444780.02779968470.0375041076
53Primary oxalosis0.1940071870.09533539690.06099481510.0470554590.077540676500.02322054280.00781221150.04088322380.052378910.00940360410.07288729990.03455338340.01297255670.05982692730.07505779120.05559936940.0375041076
54Fabrys disease0000.00941109180.00861563070.03193092780.03096072380.0624976920.04088322380.09602800160.12224685390.07288729990.01151779450.01297255670.014956731800.02779968470
59Hereditary nephropathy - other specified type1.26104671530.23304208120.13215543260.21645511140.25846892160.19956829860.11610271420.17186865290.17170954010.11348763830.16926487470.15618707130.18428471120.09080789670.14956731820.075057791200
60Renal hypoplasia (congenital) - type unspecified0.50657432150.40252723120.66077716320.52702114090.2757001830.31132654590.19350452370.34373730590.26982927730.21824545820.2538973120.40608638530.24187368350.37620414350.55339907730.35652450830.33359621640.0375041076
61Oligomeganephronic hypoplasia00.04237128750.06099481510.0941109180.02584689220.01596546390.00774018090.00781221150000.02082494280.04607117780.01297255670.04487019550.018764447800
63Congenital renal dysplasia with or without urinary tract malformation1.21793400710.68853342180.92508802850.65877642610.46524405890.25544742230.23220542850.17186865290.22894605350.14840691160.15986127050.08329977130.11517794450.12972556670.10469712270.07505779120.11119873880.0750082153
66Syndrome of agenesis of abdominal muscles (Prune Belly)0.09700359350.06355693120.06099481510.02823327540.03446252290.023948195800.007812211500.0087298183000.01151779450.038917670.0448701955000
70Renal vascular disease - type unspecified00.03177846560.040663210.06587764260.05169378430.19158556670.20898488560.44529605540.67866151561.5102585712.83988845265.74768422219.790125283418.69345416631.663401263140.512442808535.11100177816.3517909299
71Renal vascular disease due to malignant hypertension00.021185643700.12234419340.43939716670.63861855571.05266460921.5390056651.68438882192.19991421912.52956951572.25950629752.63757492933.56745308514.05327432324.07188517343.22476342541.650180736
72Renal vascular disease due to hypertension0.01077817710.01059282190.03049740750.0941109180.34462522880.75037680291.11458605671.78118422143.22159803815.14186299619.159110439715.191795797223.473265091338.398767752455.773652957174.250919959975.225946802440.9169814324
73Renal vascular disease due to polyarteritis0.01077817710.02118564370.06099481510.02823327540.07754067650.07982731950.10062235230.1093709610.26165263250.27935418650.32912614520.69763558490.90990576161.45292634742.27342323672.19544039311.83477919030.3375369687
74Wegeners granulomatosis0.010778177100.13215543260.16939965240.23262202940.20755103060.19350452370.35936172890.44971546220.73330473971.09081808111.54104576972.45329021812.76315457143.64944256413.75288956082.47417193840.7125780451
75Cholesterolembolia0000.018822183600.01596546390.02322054280.05468548050.01635328950.03491927330.19747568710.29154919970.70258546151.41400867742.03411552752.94601830522.25177446080.6375698298
76Glomerulonephritis related to liver cirrhosis0000.0094110918000.01548036190.0156244230.02452993430.0261894550.12224685390.09371224280.13821353340.12972556670.08974039090.15011558240.02779968470
78Cryoglobulinaemic glomerulonephritis00.010592821900.00941109180.008615630700.01548036190.0156244230.03270657910.052378910.0658252290.08329977130.09214235560.02594511330.11965385460.15011558240.13899842350.0375041076
79Renal vascular disease - due to other cause (not given above and not code 84-88)0.05389088530.02118564370.03049740750.05646655080.05169378430.04789639170.10836253330.1406198070.26982927730.64600655640.97797483131.65558295533.01766214625.46144635947.92706786468.800526027.08891959891.8752053819
80Diabetes glomerulosclerosis or diabetic nephropathy - Type I0.032334531200.0203316050.05646655080.93910374854.48629535368.854767006411.663631765714.039299064316.019216634817.65056498521.814127618324.936024986627.644518270427.10159805820.265603628210.25808365492.5127752117
81Diabetes glomerulosclerosis or diabetic nephropathy - Type II0.0215563541000.01882218360.01723126140.06386185560.34830814270.70309903482.07686777075.622003004313.992562971628.196972596845.207343220564.253073201976.757947700769.203283500742.950512863911.7012815829
82Myelomatosis/light chain deposit disease0000.009411091800.03991365970.01548036190.11718317250.40883223831.01265892621.87131722542.92590446815.25211426977.52408287049.901356464910.73326414387.45031553.5253861179
83Amyloid000.03049740750.08469982620.26708455230.37518840150.6192144760.70309903480.8421944111.78961275762.25686499543.75890218155.60916589777.4203024177.04462068736.66137897042.77996847020.7875862604
84Lupus erythematosus0.010778177100.20331605020.55525441631.09418510151.24530618361.26938967571.31245153161.30008651791.13487638281.04380006041.11413444160.90990576160.83024362710.62818273640.54416898630.19459779290.0750082153
85Henoch-Schoenlein purpura00.06355693120.12198963010.25409947860.23262202940.23149922640.16254379990.08593432650.1390029610.11348763830.16926487470.18742448550.26490927240.28539624680.29913463640.26270226930.25019716230.1125123229
86Goodpastures Syndrome00.01059282190.03049740750.31997712130.42216590530.23149922640.1470634380.15624422990.22894605350.26189454990.3197225410.47897368520.78321002270.90807896711.21149527741.06957352480.75059148690.3000328611
87Systemic sclerosis (scleroderma)00000.04307815360.07184458750.04644108570.11718317250.15535625060.27935418650.45137299910.52062357080.63347869480.64862783370.44870195460.28146671710.11119873880.0375041076
88Haemolytic Uraemic Syndrome (including Moschcowitz Syndrome)0.64669062320.26482054680.23381345770.39526585570.53416910470.35124020560.50311176170.41404720940.44971546220.55870837310.45137299910.35402402820.36856942240.38917670020.44870195460.43158229950.33359621640
89Multi-system disease - other (not mentioned above)0.02155635410.01059282190.0203316050.07528873440.18092824510.07982731950.22446524750.24999076790.43336217260.56743819140.84632437330.84341018480.97901252831.80318537761.97428860032.27049818431.77917982090.3375369687
90Tubular necrosis (irreversible) or cortical necrosis (different from 88)0.31256713460.10592821870.12198963010.15057746880.11200319940.17562010280.17802416180.24217855640.45789210690.56743819140.80870995671.25990904141.77374034552.46478576793.61952910054.14694296472.86336752431.5001643055
91Tuberculosis00000.00861563070.01596546390.05418126660.03906105750.16353289530.15713672990.28210812440.45814874230.72562105040.88213385381.10679815470.90069349460.58379337870.3750410764
92Gout00.0105928219000.03446252290.02394819580.00774018090.0468732690.08176644770.09602800160.16926487470.41649885670.55285413370.47998459690.50852888190.46911119510.36139590110.0750082153
93Nephrocalcinosis and hypercalcaemic nephropathy0.010778177100.01016580250.06587764260.0603094150.11175824720.06192144760.07030990350.15535625060.25316473160.1880720830.22907437120.49526516140.45403948360.5833125410.52540453850.38919558580.0375041076
94Balkan nephropathy00000.01723126140.00798273190.01548036190.02343663450.01635328950.0261894550.07522883320.10412471420.10366015010.19458835010.19443751370.07505779120.05559936940
95Kidney tumour0.22634171810.06355693120.0203316050.05646655080.05169378430.03991365970.09288217140.13280759550.22894605350.46268037150.93095681061.79094508372.54543257373.87879444534.99554842793.84671179982.80776815491.237635552
96Traumatic or surgical loss of kidney0.04311270820.01059282190.040663210.02823327540.07754067650.04789639170.03870090470.0781221150.16353289530.20078582160.39495137420.76011041340.92142355611.29725566731.57045684111.76385809361.11198738810.4875533993
98Other identified renal disorders00000000.01562442300.008729818300.01041247140.03455338340.02594511330.04487019550.056293343400
99Chronic renal failure; aetiology uncertain0.51735249860.30719183430.40663210040.54584332450.63755667330.79029046260.65017519981.03121191771.25102664931.78088293922.00296768343.34240332484.63015336936.25277231647.82237074199.06322828937.45031555.1005586387
FR080000000.07982731950.13158307610.19530528740.37612565930.57616800981.07201087282.1241441693.0637333243.63231586855.11520228257.01790347866.56072558963.1503450415
TotalTotal8.43931263346.37687876810.653761031318.408095564227.311549383135.235778808944.954970955558.857201421979.7549930538110.1703073195148.5205239068204.9278499551274.227168086368.3687192897465.7227154138500.9544630198401.6776442525186.9579765724
Cystic KD
0-45-910-1415-1920-2425-2930-3435-3940-4445-4950-5454-5960-6464-6970-7475-7980-8485+
unknown5851091321458413314818719516015713076151401
dominant4517166416155211221814213319171569126311246912967812817
recessive37212019141510911122215147101120249
medullary54183622832243017112217975862409
other2031191153101720151317169102173
00000
00000
00000
00000
00000
00000
00000
00000
00000
00000
00000
00000
00000
00000
00000
00000
00000
00000
unknown
dominant
recessive
medullary
other
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
unknown
recessive
medullary
other
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
recessive
medullary
other
Cystic KD
0-45-910-1415-1920-2425-2930-3435-3940-4445-4950-5454-5960-6464-6970-7475-7980-8485+
unknown0.05389088530.0847425750.05082901260.0941109180.07754067650.10377551530.16254379990.35154951740.68683816041.16106583781.39173341381.9471321552.2459699182.07560906772.34820689582.43937821452.11277603730.5625616146
dominant0.04311270820.05296410940.01016580250.06587764260.13785009150.51089484451.24616913294.31234074669.174195428215.835890449920.057887646819.960707706118.071419493816.384339078116.811366565812.96623343258.22870667172.9253203957
recessive0.3987925510.22244925940.20331605020.17881074420.12061883010.11974097920.07740180950.07030990350.08994309240.104757820.20687929120.15618707130.16124912230.09080789670.14956731820.20640892580.05559936940
medullary0.05389088530.43430569680.84376160840.58348769170.24123766020.25544742230.18576434280.23436634490.1390029610.09602800160.20687929120.17701201410.10366015010.09080789670.07478365910.15011558240.16679810820.0750082153
other0.021556354100.03049740750.10352200980.07754067650.08781005140.03870090470.02343663450.08176644770.14840691160.1880720830.15618707130.14973132790.22053346340.23930770910.16888003020.2779968470.0750082153
00000
00000
00000
00000
00000
00000
00000
00000
00000
00000
00000
00000
00000
00000
00000
00000
00000
00000
unknown
dominant
recessive
medullary
other
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
unknown
recessive
medullary
other
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
recessive
medullary
other
0-45-910-1415-1920-2425-2930-3435-3940-4445-4950-5454-5960-6464-6970-7475-7980-8485+
21Pyelonephritis associated with neurogenic bladderPN_neurogenic14183049504648393434372627181722482
22Pyelonephritis due to congenital obstructive uropathy with/without vesico-ureteric refluxPN_obstructive8046981431341301189286544533344041383191252
24Pyelonephritis due to vesico-ureteric reflux without obstructionPN_refluxive15208718719918619915212913110285817369431661780
60Renal hypoplasia (congenital) - type unspecifiedHypodys_congenital47386556323925443325273921293719121589
61Oligomeganephronic hypoplasiaOligomeganephronia046103211000241310038
63Congenital renal dysplasia with or without urinary tract malformationDysplasia__CAKUT11365917054323022281717810107442584
66Syndrome of agenesis of abdominal muscles (Prune Belly)Prune_belly96634301010013300040
0000000
0000000
0000000
0000000
0000000
0000000
0000000
0000000
0000000
0000000
0000000
0000000
0000000
0000000
0000000
0000000
0000000
0000000
PN_neurogenic
PN_obstructive
PN_refluxive
Hypodys_congenital
Oligomeganephronia
Dysplasia__CAKUT
Prune_belly
0-45-910-1415-1920-2425-2930-3435-3940-4445-4950-5454-5960-6464-6970-7475-7980-8485+
21PN_neurogenic0.01077817710.04237128750.18298444520.28233275410.42216590530.39913659730.35604832370.37498615190.31888914590.29681382320.3197225410.38526144240.29946265570.35025903020.26922117280.31899561270.05559936940.0750082153
22PN_obstructive0.86225416430.48726980620.99624864611.34578612761.15449451651.0377551530.91334135210.71872345780.70319144990.47141018980.42316218660.34361155680.39160501130.51890226690.61322600460.71304901650.86179022570.3375369687
24PN_refluxive0.16167265580.21185643750.88442481841.75987416691.71451051331.48478814191.5402960091.18745614761.05478717491.14360620120.95916762310.88506007040.93294135050.94699663711.03201449560.80687125560.44479495520.2250246458
60Hypodys_congenital0.50657432150.40252723120.66077716320.52702114090.2757001830.31132654590.19350452370.34373730590.26982927730.21824545820.2538973120.40608638530.24187368350.37620414350.55339907730.35652450830.33359621640.0375041076
61Oligomeganephronia00.04237128750.06099481510.0941109180.02584689220.01596546390.00774018090.00781221150000.02082494280.04607117780.01297255670.04487019550.018764447800
63Dysplasia__CAKUT1.21793400710.68853342180.92508802850.65877642610.46524405890.25544742230.23220542850.17186865290.22894605350.14840691160.15986127050.08329977130.11517794450.12972556670.10469712270.07505779120.11119873880.0750082153
66Prune_belly0.09700359350.06355693120.06099481510.02823327540.03446252290.023948195800.007812211500.0087298183000.01151779450.038917670.0448701955000
0000000
0000000
0000000
0000000
0000000
0000000
0000000
0000000
0000000
0000000
0000000
0000000
0000000
0000000
0000000
0000000
0000000
0000000
PN_neurogenic
PN_obstructive
PN_refluxive
Hypodys_congenital
Oligomeganephronia
Dysplasia__CAKUT
Prune_belly
*
CAKUT Diagnosis CodesERA-EDTA Annual Report 2009Pyelonephritis associated with neurogenic bladderPyelonephritis due to congenital obstructive uropathy w/o VUR Pyelonephritis due to VUR without obstruction
Renal hypoplasia (congenital) unspecifiedOligomeganephronic hypoplasiaCongenital renal dysplasia w/o urinary tract malformationSyndrome of agenesis of abdominal muscles (prune belly)
CODE212224
60616266
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Characteristics of RRT Patients in the ERA-EDTA Registry
ALLCAKUTPrevalence 2009 (cases pmp)947.544.9Incidence (no of patients) 1.1.1999-31.12.2009212 9304 765Gender (% male)61.561.5CAKUT diagnoses (%)2.2100Neurogenic PN5.6Obstructive PN22.9Refluxive PN41.9Hypoplasia17.3Dysplasia12.3
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Caratteristiche deio pazienti pediatrici del RRDTL
ALLCAKUTIncidence 2010 (cases pmp)16742.9Incidence (no of patients) 1.1.1995-31.12.201012 57654Gender (% male)62.664.8CAKUT diagnoses (%)1.5100Neurogenic PN11.9Refluxive PN64.4Hypoplasia22.7Prune Belly1.0
*
Age Distribution at Start of RRTPercent of patients starting RRT at given age groups
CAKUT
Other diagnoses
*
*
63%37%
*
*
*
Anno di incidenza. RRDTL 1995-2010
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Et allingresso, per sesso. RRDTL 1995-2010
*
Metodica dialitica per anno. RRDTL, 1995-2010
*
Et allingresso per metodica dialitica. RRDTL 1995-2010
MetodicaMediaDSMedianaRIQHD10,95,0129-15DP4,75,040-8Totale9,55,6115-14
*
Centro dialisi allingresso. RRDTL 1995-2010
*
Paese di nascita. RRDTL 1995-2010
*
Paese di nascita per anno. RRDTL 1995-2010
*
Tipologia di accesso vascolare per anno. RRDTL, 2002-2010
*
Incidenza cumulativa di trapianto per nefropatia. RRDTL, 1995-2010Mesi Cakut Glomerulopathies Hereditary Other 12 0.28 0.29 0.08 0.08 24 0.52 0.45 0.39 0.17 36 0.74 0.66 0.39 0.41 48 0.81 0.83 0.39 0.41 60 0.88 0.87 0.51 0.41
*
Incidenza cumulativa di trapianto per quartili di et allingresso. RRDTL, 1995-2010Mesi 0-5 6-11 12-14 15-17 12 0.11 0.31 0.30 0.19 24 0.16 0.48 0.45 0.65 36 0.46 0.72 0.65 0.73 48 0.52 0.77 0.71 0.84 60 0.66 0.77 0.83 0.88
*
Dialysis Unit, Bambino Ges Pediatric HospitalRoma, Italy.Doctor:S. Picca
Headnurse:Tancredi
Nurses:N. AvariV. BandinuD. CiulloE. IacoellaP. LozziF. PaolucciC. Pia
TransplantCoordinators:S. TeseiI. Pannacci
*