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Determine the function of the gene
What is the function of the protein that the gene encodes?
Is it involved in neural transmission?
Neural development?
Synaptic development?
Bourgeron 2009
Create a genetically modified animal model
Control > ASD
Compare animals with extremely similar genetics except for a specific modification.
What about humans?
Human genetics – SFARI, Autism Speaks
Neuroimaging – MRI, fMRI, DTI
Electrophysiology – EEG
Post mortem