Lecture 10 – Second Messengers IV – Niric Oxide, cGMP, and ROS Signalling BIOL 5190/6190 Cellular & Molecular Singal Transduction Prepared by Bob Locy

Lecture 10 – Second Messengers IV – Niric Oxide, cGMP, and ROS Signalling

BIOL 5190/6190 Cellular & Molecular Singal TransductionPrepared by Bob Locy

Last modified -13F

CSB Fig 02:01 Cell signalling pathways

Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

Transducers Second Messengers II

1. Nitric Oxide• cyclic GMP Signaling

2. Redox signaling3. ROS signaling


CSB Fig 2:45 NO and cyclic GMP signalling


CSB Fig 2:46 NO synthase mechanism


CSB Fig 2:47 eNOS activation


CSB Fig 2:48 Summary of redox signalling


CSB Fig 2:49 Reactive oxygen species (ROS)


CSB Fig 2:50 Sites of ROS formation


CSB Fig 2:51 Plasma membrane ROS formation


CSB Fig 2:52 GSH/GSSG couple


CSB Fig 2:53 H2O2 metabolism


CSB Fig 2:54 Peroxiredoxin catalytic cycles


CSB Fig 2:55 Reversible & irreversible ROS oxidations


CSB Fig 2:56 ROS formation and action CSB Fig 2:56 ROS formation and action


CSB Fig 2:57 Recovery of protein oxidation CSB Fig 2:57 Recovery of protein oxidation


CSB Fig 2:58 Thimerosal-induced Ca2+ signalling CSB Fig 2:58 Thimerosal-induced Ca2+ signalling


Module 2:59 Figure ROS effects on Ca2+ signalling Module 2:59 Figure ROS effects on Ca2+ signalling


CSB Fig 2:60 ROS microdomains CSB Fig 2:60 ROS microdomains


CSB Fig 2:61 ROS microdomains CSB Fig 2:61 ROS microdomains

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Lecture 10 – Second Messengers IV – Niric Oxide, cGMP, and ROS Signalling BIOL 5190/6190 Cellular & Molecular Singal Transduction Prepared by Bob Locy