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Layer-Specific Attentional Modulation in Early Visual Areas
Elizabeth A. BuffaloLaboratory of Neuropsychology
National Institute of Mental Health, NIH
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Fries, Reynolds, Rorie, and Desimone (Science, 2001)
Attentional Modulation in Area V4
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Unattended stimulus
Attended stimulus
V4
v2 v2
pp
V1V4
TETEO
V2
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1°
RF
1°
RF
1°
RF
1°
RF
Resp
on
se/
Rew
ard
0.5-5.0s1.0s
Spatial Attention Task
fix
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Electrode Path
Modified from Gegenfurtner, Kiper, and Levitt (1997)
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Superficial Recording Deep Recording
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Electrode Path
Modified from Gegenfurtner, Kiper, and Levitt (1997)
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Attentional Modulation in Area V2Superficial Layers
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Attentional Modulation in Area V2Deep Layers
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Superficial Layers
Deep Layers
Area V1 Area V2
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Superficial Layers Deep Layers
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Cortical Circuitry
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Feedforward intracortical connections V1 (II/III) to V2 (IV)
Cortical Circuitry
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Feedforward intracortical connections V1 (II/III) to V2 (IV)
Feedback intracortical and subcortical connectionsV2 (VI) to V1 (VI)V1 (V) to SC,V1 (VI) to LGN,V2 (V) to SC, Pons, Striatum
Cortical Circuitry
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V1
TE
V2
V4
TEO
pfc
Superficial LayersGamma-frequency synchronization:
Attention
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Superior Colliculus, Striatum, Pons, LGN
V1
TE
V2
TEO
pfc
V1
TE
V2
V4
TEO
pfc
Superficial LayersGamma-frequency synchronization:
Attention
Deep LayersBeta-frequency synchronization:
???
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Baker, Kilner, Pinches, and Lemon (1999)
Beta-frequency Oscillations
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Synchronization correlated with behavioral response
Superficial Layers Deep Layers
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Synchronization correlated with behavioral response
Superficial Layers Deep Layers
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Superior Colliculus, Striatum, Pons, LGN
V1
TE
V2
TEO
pfc
V1
TE
V2
V4
TEO
pfc
Superficial LayersGamma-frequency synchronization:
Attention
Deep LayersBeta-frequency synchronization:
Motor response inhibition?
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Superficial Layers: Coherence Across Time
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Deep Layers: Coherence Across Time
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Cortical Circuitry
LGN
Higher Cortical Areas
SC
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Cortical Circuitry
LGN
Higher Cortical Areas
SC
Inhibitory Interneurons
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Collaborators
Robert DesimonePascal FriesTim BuschmanDavid HeisterPartha Mitra