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• Vitiligo is an acquired pigmentary anomaly of the skin manifested by depigmented white patches surrounded by a normal or a hyperpigmented border which may slowly enlarge with concurrent development of new lesions.
Theories• autoimmune, • cytotoxic, • biochemical,• oxidant-antioxidant, • neural, and • viral
GENETICS
MELASMA
Treatment options
• Sun screen• Depigmenting agentsHydroquinone 4% Azelaic acid 20% Tretinoin 0.05 %
Combination Therapy
• Mild steroid(0.1% H.cort)
• Tretinoin 0.05%
• Hydroquinine 4%