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Vision Science Theme
Lana J. NagyUniversity of Rochester
High Tech Maui Industry Education Exchange
March 2005
Goals of Vision Science
•Advance Vision Science
•Demonstrate value of Adaptive Optics (AO) to eye care
•Increase accessibility of Adaptive Optics to scientists and clinicians
•Develop novel ophthalmic instruments
•Education
Anatomy of the Eye
Ganglion cellsAmacrine cells Rods
Cones
Aberrations in Lens and Cornea Distort Wave front
Deformable MirrorCorrects Wavefront
Sharp Image in Camera
Wavefront SensorMeasures Wavefront
Courtesy of David Williams
Principle of AO
Without adaptive optics (single image)
With adaptive optics(single image)
1 deg retinal eccentricity
With adaptive optics(many images)
AO and Retinal Imaging
Courtesy of David Williams
AO Ophthalmoscope
Human Trichromatic Cone MosaicRoorda, A. and Williams, D.R. (Nature, 1999),
Heidi Hofer (2003)
NC-DeuteranopeHas L and M genes, but M gene defective
Joe Carroll (2004)
University of RochesterMissing Photoreceptors
AO Scanning Laser Ophthalmoscope (SLO)
Austin Roorda
Nerve fiber layer
Blood vessel just below nerve
layer
Photoreceptor layer
University of HoustonConfocal capabilities allow for:
•Sectioning through retinal layers
•Monitoring of real time dynamics
Flood Illuminated Retinal AO Camera
Indiana University
24μm
Registered stack of 120 images 30 Hz images rate0.8o Field of view1.4o retinal ecc.
•Real time imaging of photorecptoractivity
•Working to combine AO with optical coherence tomography to produce high resolution 3-D retinal views
Juntae Rha, Ravi Jonnal, Yan Zhang, Don Miller
AO Phoropter
Lawrence Livermore National Laboratories
Deformable mirror
Wavefrontsensor
Vision Science in the
Center for Adaptive Optics
Thank You!
Keck TelescopeMauna Kea, Hawaii