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endokrin drugs
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Major Endocrine Organs
HORMONAL DISEASE
PANCREAS
OVARIUM & TESTIS
ADRENAL
THYROID
REPRODUCTION
METABOLISM
GROWTH & DEVELOPMENT
ENERGY & NUTRITION
HYPER / HYPO SECRETIONDISEASE
HORMONAL DISEASE (MOST)
GROWTH DISORDERSSTRUMA ( HYPO & HIPERTHYROIDI)
DIABETES MELLITUSLIPID DISORDERS
INFERTILITYMENSTRUATION & MENOPAUSE
CARCINOMAOSTEOPOROSIS
HIPERTENSI
THYROID
PANCREAS
OVARIUM & TESTIS
ADRENAL
Waah capek sekali
Bapak kurang minum
hormon seks
Gara-gara hormon seks
POROS HIPOTALAMUS-HIPOPISIS-OVARIUM/TESTIS
Ovarian hormones
OVARIUM
ESTROGEN ( blood stream)
UTERUS; VAGINA; MAMMA
HYPOTALAMUS
PROGESTERON
F S H L H
HYPHOPHYSIS (gland) GnRH
Paired ovaries in the abdominopelvic cavity produce estrogens and progesterone
They are responsible for: Maturation of the reproductive organsAppearance of secondary sexual
characteristicsBreast development and cyclic changes in the
uterine mucosa
Gonads: Female
ESTROGEN & PROGESTERONE
SIDE EFFECT / TOXICITYPHYSIOLOGIC / BALANCE
HYPER HORMONAL
NON HORMONAL ?MENSTRUAL DISTURBANCE
CLINICAL USE
Hypo secretion; menopause (HRT) Hormonal contraceptive
ANTI ESTROGEN
Preparat : ClomiphenTamoxiphene
Clinical use: infertility ---- induce ovulation
( an ovulatoir)
Mech of action : blocking estrogen receptor
FSH & LH increase
Mechanism of action ANTI ESTROGEN
OVARIUM
ESTROGEN ( blood stream) Clomiphene
UTERUS; VAGINA; MAMMA
HYPHOPHYSIS (gland)
PROGESTERON
F S H
L H
TESTIS
TESTOSTERONE ( blood stream)
Penis, Larynx, skeleton, Muscle massPubic and axillary hair
HYPOTALAMUS
F S H L H
HYPHOPHYSIS (gland)
GnRH
Testes located in an extra-abdominal sac (scrotum) produce testosterone
Testosterone:Initiates maturation of male reproductive organsCauses appearance of secondary sexual
characteristics and sex driveIs necessary for sperm productionMaintains sex organs in their functional state
Gonads: Male
TESTOSTERONE
SIDE EFFECT / TOXICITY
NON HORMONAL ?
CLINICAL USE
HYPOGONADISM, STIMULATE RBC,INCREASE MUSCLE BULK
Hormonal contraceptive
MECHANISM OF GLUCOCORTICOID
Dexamethasone
Prenisone,Triamcinolone
Cortisol
Aldosteron
Fludocortisone
Spironolactone
Mifepristone
Aminoglotethimide
Metyrapone
Ketoconazole
INFLAMATION
SIDE EFFECT / TOXICITY
HYPERGLYCEMIA CUSHING SYNDROOM
HYPERTENSION
PREDNISON (STEROID)
The hyperglycemic effects of glucagon and the hypoglycemic effects of insulin
Regulation of Blood Glucose Levels