PENGARUH VIRGIN COCONUT OIL (VCO) DI DALAM BASIS KRIM TERHADAP
PENETRASI ZAT AKTIFHenny Lucida, Vinny Hosiana dan Vivi Muharmi
Jurusan Farmasi FMIPA Universitas Andalas Padang E-mail:
[email protected] ABSTRACTA study on formulation of cream in a
base containing Virgin Coconut Oil (VCO) with Piroxicam (1%) as a
model has been undertaken. VCO concentration in the creambase were
made 0 %, 31%, 36% and 41% respectively to determine the influence
of VCO concentration on the penetration profile of the drug. The
profil of penetration was d tr n db u i Fa zd fs n c l(eta t e wt
temi si a dp 8 eemi e y s g rn i i e v rc ly ) i h n f o u l i p h
cs k n H e n phosphate buffer as membrane and medium respectively.
Concentration of piroxicam released was determined
spectrophotometically at wavelength 353.2 nm. Results indicated
that the penetration profile of piroxicam from formula 1, 2 and 3
followed zero order kinetic with the slope (k) of 0.0171 (r =
0.9913); 0.0217 (r = 0.9869) and 0.0217 (r = 0.9939) respectively,
while that from formula 4 followed Higuchi equation with the slope
(k) of 0,0570 mg/sec (r = 0.9853). The highest rate was observed
from Formula 4 (VCO concentration was 41%). Statistical anlysis
showed that VCO affected the release of piroxicam from the
formulation significantly (p0,01) yang menunjukkan bahwa penetrasi
piroksikam dari masing-masing formula krim sangat berbeda nyata.
Selanjutnya dilakukan uji beda nyata terkecil terhadap data
konsentrasi piroksikam yang
berpenetrasi setelah 240 menit dengan uji Student Newman Keuls
(SNK) , hasilnya dapat dilihat pada Tabel V.
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Tabel V. Hasil uji beda nyata terkecil terhadap konsentrasi
rata-rata piroksikam berpenetrasi setelah 240 menit. Q.sx 0,828
0,760 0,740 Formula I II III Rata-rata 5,7957 6,4766 7,2616 IV
9,1115 3,3158* 2,6349* 1,8499* III 7,2616 1,4659* 0,7850* II 6,4766
0,6809 I 5,7957 Keterangan : * = berbeda nyata, Q.sx = nilai nyata
terkecil Formula 0,602 IV 9,1115 -
KESIMPULAN Penelitian ini menunjukkan Virgin Coconut Oil (VCO)
di dalam basis krim dapat meningkatkan laju penetrasi piroksikam
melalui mebran kulit mencit secara in-vitro. Selanjutnya VCO juga
meningkatkan konsentrasi berpenetrasi secara bermakna ( p
