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Kit Summary
Product Code(s) AB108667Product name 17 beta Estradiol ELISA Kit
Stop Solution
Chemical Name EC-No CAS-No Weight % Classification(67/548)
Classification(Reg. 1272/2008)
REACHRegistration
NumberSulphuric acid 231-639-5 7664-93-9 1.5 C; R35 Skin Corr. 1A
(H314)no data available
17 beta Estradiol-HRP Conjugate
Chemical Name EC-No CAS-No Weight % Classification(67/548)
Classification(Reg. 1272/2008)
REACHRegistration
NumberProclin - 55965-84-9 0.010 T; R20/21/22
C; R34R43
N; R50-53
Skin Corr. 1B(H314)
Skin Sens. 1(H317)
Aquatic Acute 1(H400)
Aquatic Chronic 1(H410)
no data available
TMB Substrate Solution
Chemical Name EC-No CAS-No Weight % Classification(67/548)
Classification(Reg. 1272/2008)
REACHRegistration
NumberDMSO 200-664-3 67-68-5 5 -
TMB 259-364-6 54827-17-7 0.03 Xi; R36/37/38 STOT SE 3 (H335) Skin Irrit. 2 (H315) Eye Irrit. 2 (H319)
Hydrogen peroxide 231-765-0 7722-84-1 0.0015 Xn; R20/22
C; R35
Xi; R41R5
O; R8
Acute Tox. 4(H302)
Acute Tox. 4(H332)
Skin Corr. 1A(H314)
Eye Dam. 1(H318)
17 beta Estradiol Standard 0
Chemical Name EC-No CAS-No Weight % Classification(67/548)
Classification(Reg. 1272/2008)
REACHRegistration
NumberSodium EDTA 200-573-9 64-02-8 0.46 Xn;R22
Xi;R41Eye Dam. 1 (H318)
Acute Tox. 4(H302)
Proclin - 55965-84-9 0.0015 T; R20/21/22C; R34
R43N; R50-53
Skin Corr. 1B(H314)
Skin Sens. 1(H317)
Aquatic Acute 1(H400)
Aquatic Chronic 1(H410)
17 beta Estradiol Control
Chemical Name EC-No CAS-No Weight % Classification(67/548)
Classification(Reg. 1272/2008)
REACHRegistration
NumberSodium EDTA 200-573-9 64-02-8 0.46 Xn;R22
Xi;R41Eye Dam. 1 (H318)
Acute Tox. 4(H302)
no data available
Proclin - 55965-84-9 0.0015 T; R20/21/22C; R34
R43N; R50-53
Skin Corr. 1B(H314)
Skin Sens. 1(H317)
Aquatic Acute 1(H400)
Aquatic Chronic 1(H410)
no data available
17 beta Estradiol Standard 1 (20 pg/mL)
Chemical Name EC-No CAS-No Weight % Classification(67/548)
Classification(Reg. 1272/2008)
REACHRegistration
NumberSodium EDTA 200-573-9 64-02-8 0.46 Xn;R22
Xi;R41Eye Dam. 1 (H318)
Acute Tox. 4(H302)
no data available
Proclin - 55965-84-9 0.0015 T; R20/21/22C; R34
R43N; R50-53
Skin Corr. 1B(H314)
Skin Sens. 1(H317)
Aquatic Acute 1(H400)
Aquatic Chronic 1(H410)
no data available
17 beta Estradiol Standard 2 (120 pg/mL)
Chemical Name EC-No CAS-No Weight % Classification(67/548)
Classification(Reg. 1272/2008)
REACHRegistration
NumberSodium EDTA 200-573-9 64-02-8 0.46 Xn;R22
Xi;R41Eye Dam. 1 (H318)
Acute Tox. 4(H302)
Proclin - 55965-84-9 0.0015 T; R20/21/22C; R34
R43N; R50-53
Skin Corr. 1B(H314)
Skin Sens. 1(H317)
Aquatic Acute 1(H400)
Aquatic Chronic 1(H410)
17 beta Estradiol Standard 3 (300 pg/mL)
Chemical Name EC-No CAS-No Weight % Classification(67/548)
Classification(Reg. 1272/2008)
REACHRegistration
NumberSodium EDTA 200-573-9 64-02-8 0.46 Xn;R22
Xi;R41Eye Dam. 1 (H318)
Acute Tox. 4(H302)
Proclin - 55965-84-9 0.0015 T; R20/21/22C; R34
R43N; R50-53
Skin Corr. 1B(H314)
Skin Sens. 1(H317)
Aquatic Acute 1(H400)
Aquatic Chronic 1(H410)
17 beta Estradiol Standard 4 (600 pg/mL)
Chemical Name EC-No CAS-No Weight % Classification(67/548)
Classification(Reg. 1272/2008)
REACHRegistration
NumberSodium EDTA 200-573-9 64-02-8 0.46 Xn;R22
Xi;R41Eye Dam. 1 (H318)
Acute Tox. 4(H302)
no data available
Proclin - 55965-84-9 0.0015 T; R20/21/22C; R34
R43N; R50-53
Skin Corr. 1B(H314)
Skin Sens. 1(H317)
Aquatic Acute 1(H400)
Aquatic Chronic 1(H410)
no data available
17 beta Estradiol Standard 5 (2,000 pg/mL)
Chemical Name EC-No CAS-No Weight % Classification(67/548)
Classification(Reg. 1272/2008)
REACHRegistration
NumberSodium EDTA 200-573-9 64-02-8 0.46 Xn;R22
Xi;R41Eye Dam. 1 (H318)
Acute Tox. 4(H302)
Proclin - 55965-84-9 0.0015 T; R20/21/22C; R34
R43N; R50-53
Skin Corr. 1B(H314)
Skin Sens. 1(H317)
Aquatic Acute 1(H400)
Aquatic Chronic 1(H410)
GHS / CLP - GHS - Classification
Signal WordWarning
Hazard statementsH317 - May cause an allergic skin reaction
Precautionary Statements - EU (§28, 1272/2008)P302 + P352 - IF ON SKIN: Wash with plenty of soap and waterP333 + P313 - If skin irritation or rash occurs: Get medical advice/ attentionP280 - Wear protective gloves/ eye protection/ face protectionP261 - Avoid breathing dust/ fume/ gas/ mist/ vapors/ sprayP272 - Contaminated work clothing should not be allowed out of the workplaceP363 - Wash contaminated clothing before reuseP501 - Dispose of contents/ container to an approved waste disposal plant
2.3 Other information
A safety datasheet follows for all potentially hazardous components – all other components are non-hazardousAvoid contact with DMSO solutions containing toxic materials or materials with unknown toxicological properties. DMSO is readilyabsorbed through skin and may carry such materials into the body.
TRANSPORT INFORMATION
DOT Not dangerous goods
IATA Not dangerous goods
ADR Not dangerous goods
Revision Date 02-Sep-2015 Version 8
Safety Data SheetIssuing date no data available
For research use only
Ozone Not applicable
E-mail address [email protected]
GHS Label elements, including precautionary statements
Product name 17 beta Estradiol Control
Emergency telephone Tel: (617)225-2272 or 888-77-ABCAM (22226) (US toll free) - Monday-Friday 8am-9pmEST
Signal WordWarning
Hazard statementsH317 - May cause an allergic skin reaction
1. PRODUCT AND COMPANY IDENTIFICATION
2. HAZARDS IDENTIFICATION
Precautionary Statements - EU (§28, 1272/2008)P302 + P352 - IF ON SKIN: Wash with plenty of soap and waterP333 + P313 - If skin irritation or rash occurs: Get medical advice/ attentionP261 - Avoid breathing dust/ fume/ gas/ mist/ vapors/ sprayP280 - Wear protective gloves/ eye protection/ face protectionP272 - Contaminated work clothing should not be allowed out of the workplaceP363 - Wash contaminated clothing before reuseP501 - Dispose of contents/ container to an approved waste disposal plant
GHS - Classification
Recommended use
Other information
Skin sensitization Category 1
Supplier Address Abcam Inc1 Kendall Square, Ste 341Cambridge, MA 02139-1517USATel: (617)225-2272 or 888-77-ABCAM (22226) (US toll free)Fax: (866) 739-9884 or (866) 457-9616 (both US toll free)
_____________________________________________________________________________________________AB108667-CP147578 - 17 beta Estradiol Control Revision Date 02-Sep-2015
Explosion Data Sensitivity to Mechanical Impact none.
Flammable properties Not flammable.
Sensitivity to Static Discharge none.
No information available
Specific hazards arising from thechemical
Thermal decomposition can lead to release of irritating gases and vapors In the event of fireand/or explosion do not breathe fumes May cause sensitization by inhalation and skincontact
Flash point not determined
Protective equipment andprecautions for firefighters
As in any fire, wear self-contained breathing apparatus pressure-demand, MSHA/NIOSH(approved or equivalent) and full protective gear.
5. FIRE-FIGHTING MEASURES
Suitable extinguishing media Use extinguishing measures that are appropriate to local circumstances and thesurrounding environment.
Move to fresh air.
3. COMPOSITION/INFORMATION ON INGREDIENTS
Sodium EDTA 64-02-8 0.1-1
Ingestion Clean mouth with water. Drink plenty of water.
Eye Dam. 1 (H318) Acute Tox. 4 (H302)
4. FIRST AID MEASURES
Notes to physician May cause sensitization of susceptible persons. Treat symptomatically.
Proclin 55965-84-9 <0.1 Skin Corr. 1B (H314) Skin Sens. 1 (H317)
Aquatic Acute 1 (H400)Aquatic Chronic 1 (H410)
General advice If symptoms persist, call a physician.
Eye contact Immediately flush with plenty of water. After initial flushing, remove any contact lenses andcontinue flushing for at least 15 minutes.
Chemical Name CAS-No
For the full text of the H-Statements mentioned in this Section, see Section 16
Weight %
_____________________________________________________________________________________________
Skin contact Wash off immediately with soap and plenty of water while removing all contaminatedclothes and shoes. May cause an allergic skin reaction. If symptoms persist, call aphysician.
Classification (Reg. 1272/2008)
Page 6 / 64
3.1 Substances
Inhalation
_____________________________________________________________________________________________AB108667-CP147578 - 17 beta Estradiol Control Revision Date 02-Sep-2015
7. HANDLING AND STORAGE
Advice on safe handling Ensure adequate ventilation. Wear personal protective equipment.
Technical measures/Storageconditions
Keep out of the reach of children. Keep container tightly closed. Keep containers tightlyclosed in a cool, well-ventilated place.
Personal precautions
Engineering measures ShowersEyewash stationsVentilation systems
9. PHYSICAL AND CHEMICAL PROPERTIES
Environmental precautions Try to prevent the material from entering drains or water courses.
Methods for cleaning up
Personal protective equipment
Soak up with inert absorbent material. Pick up and transfer to properly labeled containers.After cleaning, flush away traces with water. Prevent product from entering drains.
Use personal protective equipment. Avoid contact with the skin and the eyes.
Eye/face protection Tightly fitting safety goggles.
8. EXPOSURE CONTROLS/PERSONAL PROTECTION
Skin and body protection No special protective equipment required.Respiratory protection If exposure limits are exceeded or irritation is experienced, NIOSH/MSHA approved
respiratory protection should be worn. Positive-pressure supplied air respirators may berequired for high airborne contaminant concentrations. Respiratory protection must beprovided in accordance with current local regulations.
6. ACCIDENTAL RELEASE MEASURES
Hygiene measures When using, do not eat, drink or smoke. Remove and wash contaminated clothing beforere-use.
Exposure Guidelines This product does not contain any hazardous materials with occupational exposure limitsestablished by the region specific regulatory bodies.
Methods for containment Prevent further leakage or spillage if safe to do so.
Boiling point/boiling range
Evaporation rate No information available
No information availableNo information available
pH No information available
Vapor density no data available
Odor
Melting point/range No information available
VOC Content(%) not applicable
No information available.
Autoignition temperature No information available
Physical State @20°C No information availableOdor Threshold
Specific Gravity no data available
Decomposition temperature No information available
No information availableAppearance
solubility
_____________________________________________________________________________________________
No information available.
No information available.
Flash point
Page 7 / 64
Flammability Limits in AirExplosion limits No information available
No information available
_____________________________________________________________________________________________AB108667-CP147578 - 17 beta Estradiol Control Revision Date 02-Sep-2015
14. TRANSPORT INFORMATION
Stability
Chemical Name LD50 Oral
12. ECOLOGICAL INFORMATION
LD50 Dermal LC50 Inhalation
Incompatible products
Ecotoxicity
Sodium EDTA 10 g/kg ( Rat )
The environmental impact of this product has not been fully investigated.
None known based on information supplied.
11. TOXICOLOGICAL INFORMATION
Chemical Name Toxicity to algae Toxicity to fish Toxicity tomicroorganisms
Toxicity to daphnia andother aquatic invertebrates
Proclin 53 mg/kg ( Rat )
Sodium EDTA 1.01: 72 h Desmodesmussubspicatus mg/L EC50
41: 96 h Lepomismacrochirus mg/L LC50
static 59.8: 96 h Pimephalespromelas mg/L LC50 static
610: 24 h Daphnia magnamg/L EC50
Hazardous decomposition products None known based on information supplied.
Chronic toxicity
13. DISPOSAL CONSIDERATIONS
Stable under recommended storage conditions.
Waste disposal methods This material, as supplied, is not a hazardous waste according to Federal regulations (40CFR 261). This material could become a hazardous waste if it is mixed with or otherwisecomes in contact with a hazardous waste, if chemical additions are made to this material, orif the material is processed or otherwise altered. Consult 40 CFR 261 to determine whetherthe altered material is a hazardous waste. Consult the appropriate state, regional, or localregulations for additional requirements.
Chronic toxicity Repeated contact may cause allergic reactions in very susceptible persons Avoid repeatedexposure
Acute toxicity
Contaminated packaging Do not re-use empty containers.
10. STABILITY AND REACTIVITY
Sensitization As a precaution the product should be treated as a sensitizer.
Hazardous polymerization
Product Information May cause sensitization of susceptible persons.
Hazardous polymerization does not occur.
_____________________________________________________________________________________________
Target Organ Effects None known.
Page 8 / 64
Conditions to avoid None known based on information supplied.
_____________________________________________________________________________________________AB108667-CP147578 - 17 beta Estradiol Control Revision Date 02-Sep-2015
Clean Water ActThis product does not contain any substances regulated as pollutants pursuant to the Clean Water Act (40 CFR 122.21 and 40CFR 122.42).
SARA 313Section 313 of Title III of the Superfund Amendments and Reauthorization Act of 1986 (SARA). This product does not contain anychemicals which are subject to the reporting requirements of the Act and Title 40 of the Code of Federal Regulations, Part 372.
CERCLAThis material, as supplied, does not contain any substances regulated as hazardous substances under the ComprehensiveEnvironmental Response Compensation and Liability Act (CERCLA) (40 CFR 302) or the Superfund Amendments andReauthorization Act (SARA) (40 CFR 355). There may be specific reporting requirements at the local, regional, or state levelpertaining to releases of this material.
ADR Not dangerous goods
U.S. State Regulations
SARA 311/312 Hazard Categories
California Proposition 65This product does not contain any Proposition 65 chemicals.
Acute Health Hazard yes
U.S. State Right-to-Know Regulations
International Regulations
Chronic Health Hazard no
15. REGULATORY INFORMATION
Fire Hazard
WHMIS Note: This product has been classified in accordance with the hazard criteria of theControlled Products Regulations (CPR) and the MSDS contains all the informationrequired by the CPR.
no
IATA Not dangerous goods
Sudden Release of Pressure Hazard no
U.S. Federal Regulations
_____________________________________________________________________________________________
Reactive Hazard no
Page 9 / 64
DOT Not dangerous goods
_____________________________________________________________________________________________AB108667-CP147578 - 17 beta Estradiol Control Revision Date 02-Sep-2015
End of MSDS
Revision Note No information available.
Full text of H-Statements referred to under sections 2 and 3H314 - Causes severe skin burns and eye damage H317 - May cause an allergic skin reaction H400 - Very toxic to aquatic lifeH410 - Very toxic to aquatic life with long lasting effects
Hazard statementsH317 - May cause an allergic skin reaction
_____________________________________________________________________________________________
DisclaimerThe information provided in this Safety Data Sheet is correct to the best of our knowledge, information and belief at the date of itspublication. The information given is designed only as a guidance for safe handling, use, processing, storage, transportation, disposaland release and is not to be considered a warranty or quality specification. The information relates only to the specific materialdesignated and may not be valid for such material used in combination with any other materials or in any process, unless specified in thetext.
16. OTHER INFORMATION
Revision Date
Page 10 / 64
02-Sep-2015
Revision Date 02-Sep-2015 Version 4
Safety Data SheetIssuing date no data available
For research use only
Ozone Not applicable
E-mail address [email protected]
GHS Label elements, including precautionary statements
Product name 17 beta Estradiol Standard 1 (20 pg/mL)
Emergency telephone Tel: (617)225-2272 or 888-77-ABCAM (22226) (US toll free) - Monday-Friday 8am-9pmEST
Signal WordWarning
Hazard statementsH317 - May cause an allergic skin reaction
1. PRODUCT AND COMPANY IDENTIFICATION
2. HAZARDS IDENTIFICATION
Precautionary Statements - EU (§28, 1272/2008)P302 + P352 - IF ON SKIN: Wash with plenty of soap and waterP261 - Avoid breathing dust/ fume/ gas/ mist/ vapors/ sprayP272 - Contaminated work clothing should not be allowed out of the workplaceP280 - Wear protective gloves/ eye protection/ face protectionP333 + P313 - If skin irritation or rash occurs: Get medical advice/ attentionP363 - Wash contaminated clothing before reuseP501 - Dispose of contents/ container to an approved waste disposal plant
GHS - Classification
Recommended use
Other information
Skin sensitization Category 1
Supplier Address Abcam Inc1 Kendall Square, Ste 341Cambridge, MA 02139-1517USATel: (617)225-2272 or 888-77-ABCAM (22226) (US toll free)Fax: (866) 739-9884 or (866) 457-9616 (both US toll free)
_____________________________________________________________________________________________AB108667-CP173216 - 17 beta Estradiol Standard 1 (20 pg/mL) Revision Date 02-Sep-2015
Explosion Data Sensitivity to Mechanical Impact none.
Flammable properties Not flammable.
Sensitivity to Static Discharge none.
No information available
Specific hazards arising from thechemical
Thermal decomposition can lead to release of irritating gases and vapors In the event of fireand/or explosion do not breathe fumes May cause sensitization by inhalation and skincontact
Flash point not determined
Protective equipment andprecautions for firefighters
As in any fire, wear self-contained breathing apparatus pressure-demand, MSHA/NIOSH(approved or equivalent) and full protective gear.
5. FIRE-FIGHTING MEASURES
Suitable extinguishing media Use extinguishing measures that are appropriate to local circumstances and thesurrounding environment.
Move to fresh air.
3. COMPOSITION/INFORMATION ON INGREDIENTS
Sodium EDTA 64-02-8 0.1-1
Ingestion Clean mouth with water. Drink plenty of water.
Eye Dam. 1 (H318) Acute Tox. 4 (H302)
4. FIRST AID MEASURES
Notes to physician May cause sensitization of susceptible persons. Treat symptomatically.
Proclin 55965-84-9 <0.1 Skin Corr. 1B (H314) Skin Sens. 1 (H317)
Aquatic Acute 1 (H400)Aquatic Chronic 1 (H410)
General advice If symptoms persist, call a physician.
Eye contact Immediately flush with plenty of water. After initial flushing, remove any contact lenses andcontinue flushing for at least 15 minutes.
Chemical Name CAS-No
For the full text of the H-Statements mentioned in this Section, see Section 16
Weight %
_____________________________________________________________________________________________
Skin contact Wash off immediately with soap and plenty of water while removing all contaminatedclothes and shoes. May cause an allergic skin reaction. If symptoms persist, call aphysician.
Classification (Reg. 1272/2008)
Page 12 / 64
3.1 Substances
Inhalation
_____________________________________________________________________________________________AB108667-CP173216 - 17 beta Estradiol Standard 1 (20 pg/mL) Revision Date 02-Sep-2015
7. HANDLING AND STORAGE
Advice on safe handling Ensure adequate ventilation. Wear personal protective equipment.
Technical measures/Storageconditions
Keep out of the reach of children. Keep container tightly closed. Keep containers tightlyclosed in a cool, well-ventilated place.
Personal precautions
Engineering measures ShowersEyewash stationsVentilation systems
9. PHYSICAL AND CHEMICAL PROPERTIES
Environmental precautions Try to prevent the material from entering drains or water courses.
Methods for cleaning up
Personal protective equipment
Soak up with inert absorbent material. Pick up and transfer to properly labeled containers.After cleaning, flush away traces with water. Prevent product from entering drains.
Use personal protective equipment. Avoid contact with the skin and the eyes.
Eye/face protection Tightly fitting safety goggles.
8. EXPOSURE CONTROLS/PERSONAL PROTECTION
Skin and body protection No special protective equipment required.Respiratory protection If exposure limits are exceeded or irritation is experienced, NIOSH/MSHA approved
respiratory protection should be worn. Positive-pressure supplied air respirators may berequired for high airborne contaminant concentrations. Respiratory protection must beprovided in accordance with current local regulations.
6. ACCIDENTAL RELEASE MEASURES
Hygiene measures When using, do not eat, drink or smoke. Remove and wash contaminated clothing beforere-use.
Exposure Guidelines This product does not contain any hazardous materials with occupational exposure limitsestablished by the region specific regulatory bodies.
Methods for containment Prevent further leakage or spillage if safe to do so.
Boiling point/boiling range
Evaporation rate No information available
No information availableNo information available
pH No information available
Vapor density no data available
Odor
Melting point/range No information available
VOC Content(%) not applicable
No information available.
Autoignition temperature No information available
Physical State @20°C No information availableOdor Threshold
Specific Gravity no data available
Decomposition temperature No information available
No information availableAppearance
solubility
_____________________________________________________________________________________________
No information available.
No information available.
Flash point
Page 13 / 64
Flammability Limits in AirExplosion limits No information available
No information available
_____________________________________________________________________________________________AB108667-CP173216 - 17 beta Estradiol Standard 1 (20 pg/mL) Revision Date 02-Sep-2015
14. TRANSPORT INFORMATION
Stability
Chemical Name LD50 Oral
12. ECOLOGICAL INFORMATION
LD50 Dermal LC50 Inhalation
Incompatible products
Ecotoxicity
Sodium EDTA 10 g/kg ( Rat )
The environmental impact of this product has not been fully investigated.
None known based on information supplied.
11. TOXICOLOGICAL INFORMATION
Chemical Name Toxicity to algae Toxicity to fish Toxicity tomicroorganisms
Toxicity to daphnia andother aquatic invertebrates
Proclin 53 mg/kg ( Rat )
Sodium EDTA 1.01: 72 h Desmodesmussubspicatus mg/L EC50
41: 96 h Lepomismacrochirus mg/L LC50
static 59.8: 96 h Pimephalespromelas mg/L LC50 static
610: 24 h Daphnia magnamg/L EC50
Hazardous decomposition products None known based on information supplied.
Chronic toxicity
13. DISPOSAL CONSIDERATIONS
Stable under recommended storage conditions.
Waste disposal methods This material, as supplied, is not a hazardous waste according to Federal regulations (40CFR 261). This material could become a hazardous waste if it is mixed with or otherwisecomes in contact with a hazardous waste, if chemical additions are made to this material, orif the material is processed or otherwise altered. Consult 40 CFR 261 to determine whetherthe altered material is a hazardous waste. Consult the appropriate state, regional, or localregulations for additional requirements.
Chronic toxicity Repeated contact may cause allergic reactions in very susceptible persons Avoid repeatedexposure
Acute toxicity
Contaminated packaging Do not re-use empty containers.
10. STABILITY AND REACTIVITY
Sensitization As a precaution the product should be treated as a sensitizer.
Hazardous polymerization
Product Information May cause sensitization of susceptible persons.
Hazardous polymerization does not occur.
_____________________________________________________________________________________________
Target Organ Effects None known.
Page 14 / 64
Conditions to avoid None known based on information supplied.
_____________________________________________________________________________________________AB108667-CP173216 - 17 beta Estradiol Standard 1 (20 pg/mL) Revision Date 02-Sep-2015
Clean Water ActThis product does not contain any substances regulated as pollutants pursuant to the Clean Water Act (40 CFR 122.21 and 40CFR 122.42).
SARA 313Section 313 of Title III of the Superfund Amendments and Reauthorization Act of 1986 (SARA). This product does not contain anychemicals which are subject to the reporting requirements of the Act and Title 40 of the Code of Federal Regulations, Part 372.
CERCLAThis material, as supplied, does not contain any substances regulated as hazardous substances under the ComprehensiveEnvironmental Response Compensation and Liability Act (CERCLA) (40 CFR 302) or the Superfund Amendments andReauthorization Act (SARA) (40 CFR 355). There may be specific reporting requirements at the local, regional, or state levelpertaining to releases of this material.
ADR Not dangerous goods
U.S. State Regulations
SARA 311/312 Hazard Categories
California Proposition 65This product does not contain any Proposition 65 chemicals.
Acute Health Hazard yes
U.S. State Right-to-Know Regulations
International Regulations
Chronic Health Hazard no
15. REGULATORY INFORMATION
Fire Hazard
WHMIS Note: This product has been classified in accordance with the hazard criteria of theControlled Products Regulations (CPR) and the MSDS contains all the informationrequired by the CPR.
no
IATA Not dangerous goods
Sudden Release of Pressure Hazard no
U.S. Federal Regulations
_____________________________________________________________________________________________
Reactive Hazard no
Page 15 / 64
DOT Not dangerous goods
_____________________________________________________________________________________________AB108667-CP173216 - 17 beta Estradiol Standard 1 (20 pg/mL) Revision Date 02-Sep-2015
End of MSDS
Revision Note No information available.
Full text of H-Statements referred to under sections 2 and 3H314 - Causes severe skin burns and eye damage H317 - May cause an allergic skin reaction H400 - Very toxic to aquatic lifeH410 - Very toxic to aquatic life with long lasting effects
Hazard statementsH317 - May cause an allergic skin reaction
_____________________________________________________________________________________________
DisclaimerThe information provided in this Safety Data Sheet is correct to the best of our knowledge, information and belief at the date of itspublication. The information given is designed only as a guidance for safe handling, use, processing, storage, transportation, disposaland release and is not to be considered a warranty or quality specification. The information relates only to the specific materialdesignated and may not be valid for such material used in combination with any other materials or in any process, unless specified in thetext.
16. OTHER INFORMATION
Revision Date
Page 16 / 64
02-Sep-2015
Revision Date 02-Sep-2015 Version 4
Safety Data SheetIssuing date no data available
For research use only
Ozone Not applicable
E-mail address [email protected]
GHS Label elements, including precautionary statements
Product name 17 beta Estradiol Standard 2 (120 pg/mL)
Emergency telephone Tel: (617)225-2272 or 888-77-ABCAM (22226) (US toll free) - Monday-Friday 8am-9pmEST
Signal WordWarning
Hazard statementsH317 - May cause an allergic skin reaction
1. PRODUCT AND COMPANY IDENTIFICATION
2. HAZARDS IDENTIFICATION
Precautionary Statements - EU (§28, 1272/2008)P302 + P352 - IF ON SKIN: Wash with plenty of soap and waterP261 - Avoid breathing dust/ fume/ gas/ mist/ vapors/ sprayP272 - Contaminated work clothing should not be allowed out of the workplaceP280 - Wear protective gloves/ eye protection/ face protectionP333 + P313 - If skin irritation or rash occurs: Get medical advice/ attentionP363 - Wash contaminated clothing before reuseP501 - Dispose of contents/ container to an approved waste disposal plant
GHS - Classification
Recommended use
Other information
Skin sensitization Category 1
Supplier Address Abcam Inc1 Kendall Square, Ste 341Cambridge, MA 02139-1517USATel: (617)225-2272 or 888-77-ABCAM (22226) (US toll free)Fax: (866) 739-9884 or (866) 457-9616 (both US toll free)
_____________________________________________________________________________________________AB108667-CP173217 - 17 beta Estradiol Standard 2 (120 pg/mL) Revision Date 02-Sep-2015
Explosion Data Sensitivity to Mechanical Impact none.
Flammable properties Not flammable.
Sensitivity to Static Discharge none.
No information available
Specific hazards arising from thechemical
Thermal decomposition can lead to release of irritating gases and vapors In the event of fireand/or explosion do not breathe fumes May cause sensitization by inhalation and skincontact
Flash point not determined
Protective equipment andprecautions for firefighters
As in any fire, wear self-contained breathing apparatus pressure-demand, MSHA/NIOSH(approved or equivalent) and full protective gear.
5. FIRE-FIGHTING MEASURES
Suitable extinguishing media Use extinguishing measures that are appropriate to local circumstances and thesurrounding environment.
Move to fresh air.
3. COMPOSITION/INFORMATION ON INGREDIENTS
Sodium EDTA 64-02-8 0.1-1
Ingestion Clean mouth with water. Drink plenty of water.
Eye Dam. 1 (H318) Acute Tox. 4 (H302)
4. FIRST AID MEASURES
Notes to physician May cause sensitization of susceptible persons. Treat symptomatically.
Proclin 55965-84-9 <0.1 Skin Corr. 1B (H314) Skin Sens. 1 (H317)
Aquatic Acute 1 (H400)Aquatic Chronic 1 (H410)
General advice If symptoms persist, call a physician.
Eye contact Immediately flush with plenty of water. After initial flushing, remove any contact lenses andcontinue flushing for at least 15 minutes.
Chemical Name CAS-No
For the full text of the H-Statements mentioned in this Section, see Section 16
Weight %
_____________________________________________________________________________________________
Skin contact Wash off immediately with soap and plenty of water while removing all contaminatedclothes and shoes. May cause an allergic skin reaction. If symptoms persist, call aphysician.
Classification (Reg. 1272/2008)
Page 18 / 64
3.1 Substances
Inhalation
_____________________________________________________________________________________________AB108667-CP173217 - 17 beta Estradiol Standard 2 (120 pg/mL) Revision Date 02-Sep-2015
7. HANDLING AND STORAGE
Advice on safe handling Ensure adequate ventilation. Wear personal protective equipment.
Technical measures/Storageconditions
Keep out of the reach of children. Keep container tightly closed. Keep containers tightlyclosed in a cool, well-ventilated place.
Personal precautions
Engineering measures ShowersEyewash stationsVentilation systems
9. PHYSICAL AND CHEMICAL PROPERTIES
Environmental precautions Try to prevent the material from entering drains or water courses.
Methods for cleaning up
Personal protective equipment
Soak up with inert absorbent material. Pick up and transfer to properly labeled containers.After cleaning, flush away traces with water. Prevent product from entering drains.
Use personal protective equipment. Avoid contact with the skin and the eyes.
Eye/face protection Tightly fitting safety goggles.
8. EXPOSURE CONTROLS/PERSONAL PROTECTION
Skin and body protection No special protective equipment required.Respiratory protection If exposure limits are exceeded or irritation is experienced, NIOSH/MSHA approved
respiratory protection should be worn. Positive-pressure supplied air respirators may berequired for high airborne contaminant concentrations. Respiratory protection must beprovided in accordance with current local regulations.
6. ACCIDENTAL RELEASE MEASURES
Hygiene measures When using, do not eat, drink or smoke. Remove and wash contaminated clothing beforere-use.
Exposure Guidelines This product does not contain any hazardous materials with occupational exposure limitsestablished by the region specific regulatory bodies.
Methods for containment Prevent further leakage or spillage if safe to do so.
Boiling point/boiling range
Evaporation rate No information available
No information availableNo information available
pH No information available
Vapor density no data available
Odor
Melting point/range No information available
VOC Content(%) not applicable
No information available.
Autoignition temperature No information available
Physical State @20°C No information availableOdor Threshold
Specific Gravity no data available
Decomposition temperature No information available
No information availableAppearance
solubility
_____________________________________________________________________________________________
No information available.
No information available.
Flash point
Page 19 / 64
Flammability Limits in AirExplosion limits No information available
No information available
_____________________________________________________________________________________________AB108667-CP173217 - 17 beta Estradiol Standard 2 (120 pg/mL) Revision Date 02-Sep-2015
14. TRANSPORT INFORMATION
Stability
Chemical Name LD50 Oral
12. ECOLOGICAL INFORMATION
LD50 Dermal LC50 Inhalation
Incompatible products
Ecotoxicity
Sodium EDTA 10 g/kg ( Rat )
The environmental impact of this product has not been fully investigated.
None known based on information supplied.
11. TOXICOLOGICAL INFORMATION
Chemical Name Toxicity to algae Toxicity to fish Toxicity tomicroorganisms
Toxicity to daphnia andother aquatic invertebrates
Proclin 53 mg/kg ( Rat )
Sodium EDTA 1.01: 72 h Desmodesmussubspicatus mg/L EC50
41: 96 h Lepomismacrochirus mg/L LC50
static 59.8: 96 h Pimephalespromelas mg/L LC50 static
610: 24 h Daphnia magnamg/L EC50
Hazardous decomposition products None known based on information supplied.
Chronic toxicity
13. DISPOSAL CONSIDERATIONS
Stable under recommended storage conditions.
Waste disposal methods This material, as supplied, is not a hazardous waste according to Federal regulations (40CFR 261). This material could become a hazardous waste if it is mixed with or otherwisecomes in contact with a hazardous waste, if chemical additions are made to this material, orif the material is processed or otherwise altered. Consult 40 CFR 261 to determine whetherthe altered material is a hazardous waste. Consult the appropriate state, regional, or localregulations for additional requirements.
Chronic toxicity Repeated contact may cause allergic reactions in very susceptible persons Avoid repeatedexposure
Acute toxicity
Contaminated packaging Do not re-use empty containers.
10. STABILITY AND REACTIVITY
Sensitization As a precaution the product should be treated as a sensitizer.
Hazardous polymerization
Product Information May cause sensitization of susceptible persons.
Hazardous polymerization does not occur.
_____________________________________________________________________________________________
Target Organ Effects None known.
Page 20 / 64
Conditions to avoid None known based on information supplied.
_____________________________________________________________________________________________AB108667-CP173217 - 17 beta Estradiol Standard 2 (120 pg/mL) Revision Date 02-Sep-2015
Clean Water ActThis product does not contain any substances regulated as pollutants pursuant to the Clean Water Act (40 CFR 122.21 and 40CFR 122.42).
SARA 313Section 313 of Title III of the Superfund Amendments and Reauthorization Act of 1986 (SARA). This product does not contain anychemicals which are subject to the reporting requirements of the Act and Title 40 of the Code of Federal Regulations, Part 372.
CERCLAThis material, as supplied, does not contain any substances regulated as hazardous substances under the ComprehensiveEnvironmental Response Compensation and Liability Act (CERCLA) (40 CFR 302) or the Superfund Amendments andReauthorization Act (SARA) (40 CFR 355). There may be specific reporting requirements at the local, regional, or state levelpertaining to releases of this material.
ADR Not dangerous goods
U.S. State Regulations
SARA 311/312 Hazard Categories
California Proposition 65This product does not contain any Proposition 65 chemicals.
Acute Health Hazard yes
U.S. State Right-to-Know Regulations
International Regulations
Chronic Health Hazard no
15. REGULATORY INFORMATION
Fire Hazard
WHMIS Note: This product has been classified in accordance with the hazard criteria of theControlled Products Regulations (CPR) and the MSDS contains all the informationrequired by the CPR.
no
IATA Not dangerous goods
Sudden Release of Pressure Hazard no
U.S. Federal Regulations
_____________________________________________________________________________________________
Reactive Hazard no
Page 21 / 64
DOT Not dangerous goods
_____________________________________________________________________________________________AB108667-CP173217 - 17 beta Estradiol Standard 2 (120 pg/mL) Revision Date 02-Sep-2015
End of MSDS
Revision Note No information available.
Full text of H-Statements referred to under sections 2 and 3H314 - Causes severe skin burns and eye damage H317 - May cause an allergic skin reaction H400 - Very toxic to aquatic lifeH410 - Very toxic to aquatic life with long lasting effects
Hazard statementsH317 - May cause an allergic skin reaction
_____________________________________________________________________________________________
DisclaimerThe information provided in this Safety Data Sheet is correct to the best of our knowledge, information and belief at the date of itspublication. The information given is designed only as a guidance for safe handling, use, processing, storage, transportation, disposaland release and is not to be considered a warranty or quality specification. The information relates only to the specific materialdesignated and may not be valid for such material used in combination with any other materials or in any process, unless specified in thetext.
16. OTHER INFORMATION
Revision Date
Page 22 / 64
02-Sep-2015
Revision Date 02-Sep-2015 Version 4
Safety Data SheetIssuing date no data available
For research use only
Ozone Not applicable
E-mail address [email protected]
GHS Label elements, including precautionary statements
Product name 17 beta Estradiol Standard 3 (300 pg/mL)
Emergency telephone Tel: (617)225-2272 or 888-77-ABCAM (22226) (US toll free) - Monday-Friday 8am-9pmEST
Signal WordWarning
Hazard statementsH317 - May cause an allergic skin reaction
1. PRODUCT AND COMPANY IDENTIFICATION
2. HAZARDS IDENTIFICATION
Precautionary Statements - EU (§28, 1272/2008)P302 + P352 - IF ON SKIN: Wash with plenty of soap and waterP261 - Avoid breathing dust/ fume/ gas/ mist/ vapors/ sprayP272 - Contaminated work clothing should not be allowed out of the workplaceP280 - Wear protective gloves/ eye protection/ face protectionP333 + P313 - If skin irritation or rash occurs: Get medical advice/ attentionP363 - Wash contaminated clothing before reuseP501 - Dispose of contents/ container to an approved waste disposal plant
GHS - Classification
Recommended use
Other information
Skin sensitization Category 1
Supplier Address Abcam Inc1 Kendall Square, Ste 341Cambridge, MA 02139-1517USATel: (617)225-2272 or 888-77-ABCAM (22226) (US toll free)Fax: (866) 739-9884 or (866) 457-9616 (both US toll free)
_____________________________________________________________________________________________AB108667-CP173218 - 17 beta Estradiol Standard 3 (300 pg/mL) Revision Date 02-Sep-2015
Explosion Data Sensitivity to Mechanical Impact none.
Flammable properties Not flammable.
Sensitivity to Static Discharge none.
No information available
Specific hazards arising from thechemical
Thermal decomposition can lead to release of irritating gases and vapors In the event of fireand/or explosion do not breathe fumes May cause sensitization by inhalation and skincontact
Flash point not determined
Protective equipment andprecautions for firefighters
As in any fire, wear self-contained breathing apparatus pressure-demand, MSHA/NIOSH(approved or equivalent) and full protective gear.
5. FIRE-FIGHTING MEASURES
Suitable extinguishing media Use extinguishing measures that are appropriate to local circumstances and thesurrounding environment.
Move to fresh air.
3. COMPOSITION/INFORMATION ON INGREDIENTS
Sodium EDTA 64-02-8 0.1-1
Ingestion Clean mouth with water. Drink plenty of water.
Eye Dam. 1 (H318) Acute Tox. 4 (H302)
4. FIRST AID MEASURES
Notes to physician May cause sensitization of susceptible persons. Treat symptomatically.
Proclin 55965-84-9 <0.1 Skin Corr. 1B (H314) Skin Sens. 1 (H317)
Aquatic Acute 1 (H400)Aquatic Chronic 1 (H410)
General advice If symptoms persist, call a physician.
Eye contact Immediately flush with plenty of water. After initial flushing, remove any contact lenses andcontinue flushing for at least 15 minutes.
Chemical Name CAS-No
For the full text of the H-Statements mentioned in this Section, see Section 16
Weight %
_____________________________________________________________________________________________
Skin contact Wash off immediately with soap and plenty of water while removing all contaminatedclothes and shoes. May cause an allergic skin reaction. If symptoms persist, call aphysician.
Classification (Reg. 1272/2008)
Page 24 / 64
3.1 Substances
Inhalation
_____________________________________________________________________________________________AB108667-CP173218 - 17 beta Estradiol Standard 3 (300 pg/mL) Revision Date 02-Sep-2015
7. HANDLING AND STORAGE
Advice on safe handling Ensure adequate ventilation. Wear personal protective equipment.
Technical measures/Storageconditions
Keep out of the reach of children. Keep container tightly closed. Keep containers tightlyclosed in a cool, well-ventilated place.
Personal precautions
Engineering measures ShowersEyewash stationsVentilation systems
9. PHYSICAL AND CHEMICAL PROPERTIES
Environmental precautions Try to prevent the material from entering drains or water courses.
Methods for cleaning up
Personal protective equipment
Soak up with inert absorbent material. Pick up and transfer to properly labeled containers.After cleaning, flush away traces with water. Prevent product from entering drains.
Use personal protective equipment. Avoid contact with the skin and the eyes.
Eye/face protection Tightly fitting safety goggles.
8. EXPOSURE CONTROLS/PERSONAL PROTECTION
Skin and body protection No special protective equipment required.Respiratory protection If exposure limits are exceeded or irritation is experienced, NIOSH/MSHA approved
respiratory protection should be worn. Positive-pressure supplied air respirators may berequired for high airborne contaminant concentrations. Respiratory protection must beprovided in accordance with current local regulations.
6. ACCIDENTAL RELEASE MEASURES
Hygiene measures When using, do not eat, drink or smoke. Remove and wash contaminated clothing beforere-use.
Exposure Guidelines This product does not contain any hazardous materials with occupational exposure limitsestablished by the region specific regulatory bodies.
Methods for containment Prevent further leakage or spillage if safe to do so.
Boiling point/boiling range
Evaporation rate No information available
No information availableNo information available
pH No information available
Vapor density no data available
Odor
Melting point/range No information available
VOC Content(%) not applicable
No information available.
Autoignition temperature No information available
Physical State @20°C No information availableOdor Threshold
Specific Gravity no data available
Decomposition temperature No information available
No information availableAppearance
solubility
_____________________________________________________________________________________________
No information available.
No information available.
Flash point
Page 25 / 64
Flammability Limits in AirExplosion limits No information available
No information available
_____________________________________________________________________________________________AB108667-CP173218 - 17 beta Estradiol Standard 3 (300 pg/mL) Revision Date 02-Sep-2015
14. TRANSPORT INFORMATION
Stability
Chemical Name LD50 Oral
12. ECOLOGICAL INFORMATION
LD50 Dermal LC50 Inhalation
Incompatible products
Ecotoxicity
Sodium EDTA 10 g/kg ( Rat )
The environmental impact of this product has not been fully investigated.
None known based on information supplied.
11. TOXICOLOGICAL INFORMATION
Chemical Name Toxicity to algae Toxicity to fish Toxicity tomicroorganisms
Toxicity to daphnia andother aquatic invertebrates
Proclin 53 mg/kg ( Rat )
Sodium EDTA 1.01: 72 h Desmodesmussubspicatus mg/L EC50
41: 96 h Lepomismacrochirus mg/L LC50
static 59.8: 96 h Pimephalespromelas mg/L LC50 static
610: 24 h Daphnia magnamg/L EC50
Hazardous decomposition products None known based on information supplied.
Chronic toxicity
13. DISPOSAL CONSIDERATIONS
Stable under recommended storage conditions.
Waste disposal methods This material, as supplied, is not a hazardous waste according to Federal regulations (40CFR 261). This material could become a hazardous waste if it is mixed with or otherwisecomes in contact with a hazardous waste, if chemical additions are made to this material, orif the material is processed or otherwise altered. Consult 40 CFR 261 to determine whetherthe altered material is a hazardous waste. Consult the appropriate state, regional, or localregulations for additional requirements.
Chronic toxicity Repeated contact may cause allergic reactions in very susceptible persons Avoid repeatedexposure
Acute toxicity
Contaminated packaging Do not re-use empty containers.
10. STABILITY AND REACTIVITY
Sensitization As a precaution the product should be treated as a sensitizer.
Hazardous polymerization
Product Information May cause sensitization of susceptible persons.
Hazardous polymerization does not occur.
_____________________________________________________________________________________________
Target Organ Effects None known.
Page 26 / 64
Conditions to avoid None known based on information supplied.
_____________________________________________________________________________________________AB108667-CP173218 - 17 beta Estradiol Standard 3 (300 pg/mL) Revision Date 02-Sep-2015
Clean Water ActThis product does not contain any substances regulated as pollutants pursuant to the Clean Water Act (40 CFR 122.21 and 40CFR 122.42).
SARA 313Section 313 of Title III of the Superfund Amendments and Reauthorization Act of 1986 (SARA). This product does not contain anychemicals which are subject to the reporting requirements of the Act and Title 40 of the Code of Federal Regulations, Part 372.
CERCLAThis material, as supplied, does not contain any substances regulated as hazardous substances under the ComprehensiveEnvironmental Response Compensation and Liability Act (CERCLA) (40 CFR 302) or the Superfund Amendments andReauthorization Act (SARA) (40 CFR 355). There may be specific reporting requirements at the local, regional, or state levelpertaining to releases of this material.
ADR Not dangerous goods
U.S. State Regulations
SARA 311/312 Hazard Categories
California Proposition 65This product does not contain any Proposition 65 chemicals.
Acute Health Hazard yes
U.S. State Right-to-Know Regulations
International Regulations
Chronic Health Hazard no
15. REGULATORY INFORMATION
Fire Hazard
WHMIS Note: This product has been classified in accordance with the hazard criteria of theControlled Products Regulations (CPR) and the MSDS contains all the informationrequired by the CPR.
no
IATA Not dangerous goods
Sudden Release of Pressure Hazard no
U.S. Federal Regulations
_____________________________________________________________________________________________
Reactive Hazard no
Page 27 / 64
DOT Not dangerous goods
_____________________________________________________________________________________________AB108667-CP173218 - 17 beta Estradiol Standard 3 (300 pg/mL) Revision Date 02-Sep-2015
End of MSDS
Revision Note No information available.
Full text of H-Statements referred to under sections 2 and 3H314 - Causes severe skin burns and eye damage H317 - May cause an allergic skin reaction H400 - Very toxic to aquatic lifeH410 - Very toxic to aquatic life with long lasting effects
Hazard statementsH317 - May cause an allergic skin reaction
_____________________________________________________________________________________________
DisclaimerThe information provided in this Safety Data Sheet is correct to the best of our knowledge, information and belief at the date of itspublication. The information given is designed only as a guidance for safe handling, use, processing, storage, transportation, disposaland release and is not to be considered a warranty or quality specification. The information relates only to the specific materialdesignated and may not be valid for such material used in combination with any other materials or in any process, unless specified in thetext.
16. OTHER INFORMATION
Revision Date
Page 28 / 64
02-Sep-2015
Revision Date 02-Sep-2015 Version 4
Safety Data SheetIssuing date no data available
For research use only
Ozone Not applicable
E-mail address [email protected]
GHS Label elements, including precautionary statements
Product name 17 beta Estradiol Standard 4 (600 pg/mL)
Emergency telephone Tel: (617)225-2272 or 888-77-ABCAM (22226) (US toll free) - Monday-Friday 8am-9pmEST
Signal WordWarning
Hazard statementsH317 - May cause an allergic skin reaction
1. PRODUCT AND COMPANY IDENTIFICATION
2. HAZARDS IDENTIFICATION
Precautionary Statements - EU (§28, 1272/2008)P302 + P352 - IF ON SKIN: Wash with plenty of soap and waterP261 - Avoid breathing dust/ fume/ gas/ mist/ vapors/ sprayP272 - Contaminated work clothing should not be allowed out of the workplaceP280 - Wear protective gloves/ eye protection/ face protectionP333 + P313 - If skin irritation or rash occurs: Get medical advice/ attentionP363 - Wash contaminated clothing before reuseP501 - Dispose of contents/ container to an approved waste disposal plant
GHS - Classification
Recommended use
Other information
Skin sensitization Category 1
Supplier Address Abcam Inc1 Kendall Square, Ste 341Cambridge, MA 02139-1517USATel: (617)225-2272 or 888-77-ABCAM (22226) (US toll free)Fax: (866) 739-9884 or (866) 457-9616 (both US toll free)
_____________________________________________________________________________________________AB108667-CP173219 - 17 beta Estradiol Standard 4 (600 pg/mL) Revision Date 02-Sep-2015
Explosion Data Sensitivity to Mechanical Impact none.
Flammable properties Not flammable.
Sensitivity to Static Discharge none.
No information available
Specific hazards arising from thechemical
Thermal decomposition can lead to release of irritating gases and vapors In the event of fireand/or explosion do not breathe fumes May cause sensitization by inhalation and skincontact
Flash point not determined
Protective equipment andprecautions for firefighters
As in any fire, wear self-contained breathing apparatus pressure-demand, MSHA/NIOSH(approved or equivalent) and full protective gear.
5. FIRE-FIGHTING MEASURES
Suitable extinguishing media Use extinguishing measures that are appropriate to local circumstances and thesurrounding environment.
Move to fresh air.
3. COMPOSITION/INFORMATION ON INGREDIENTS
Sodium EDTA 64-02-8 0.1-1
Ingestion Clean mouth with water. Drink plenty of water.
Eye Dam. 1 (H318) Acute Tox. 4 (H302)
4. FIRST AID MEASURES
Notes to physician May cause sensitization of susceptible persons. Treat symptomatically.
Proclin 55965-84-9 <0.1 Skin Corr. 1B (H314) Skin Sens. 1 (H317)
Aquatic Acute 1 (H400)Aquatic Chronic 1 (H410)
General advice If symptoms persist, call a physician.
Eye contact Immediately flush with plenty of water. After initial flushing, remove any contact lenses andcontinue flushing for at least 15 minutes.
Chemical Name CAS-No
For the full text of the H-Statements mentioned in this Section, see Section 16
Weight %
_____________________________________________________________________________________________
Skin contact Wash off immediately with soap and plenty of water while removing all contaminatedclothes and shoes. May cause an allergic skin reaction. If symptoms persist, call aphysician.
Classification (Reg. 1272/2008)
Page 30 / 64
3.1 Substances
Inhalation
_____________________________________________________________________________________________AB108667-CP173219 - 17 beta Estradiol Standard 4 (600 pg/mL) Revision Date 02-Sep-2015
7. HANDLING AND STORAGE
Advice on safe handling Ensure adequate ventilation. Wear personal protective equipment.
Technical measures/Storageconditions
Keep out of the reach of children. Keep container tightly closed. Keep containers tightlyclosed in a cool, well-ventilated place.
Personal precautions
Engineering measures ShowersEyewash stationsVentilation systems
9. PHYSICAL AND CHEMICAL PROPERTIES
Environmental precautions Try to prevent the material from entering drains or water courses.
Methods for cleaning up
Personal protective equipment
Soak up with inert absorbent material. Pick up and transfer to properly labeled containers.After cleaning, flush away traces with water. Prevent product from entering drains.
Use personal protective equipment. Avoid contact with the skin and the eyes.
Eye/face protection Tightly fitting safety goggles.
8. EXPOSURE CONTROLS/PERSONAL PROTECTION
Skin and body protection No special protective equipment required.Respiratory protection If exposure limits are exceeded or irritation is experienced, NIOSH/MSHA approved
respiratory protection should be worn. Positive-pressure supplied air respirators may berequired for high airborne contaminant concentrations. Respiratory protection must beprovided in accordance with current local regulations.
6. ACCIDENTAL RELEASE MEASURES
Hygiene measures When using, do not eat, drink or smoke. Remove and wash contaminated clothing beforere-use.
Exposure Guidelines This product does not contain any hazardous materials with occupational exposure limitsestablished by the region specific regulatory bodies.
Methods for containment Prevent further leakage or spillage if safe to do so.
Boiling point/boiling range
Evaporation rate No information available
No information availableNo information available
pH No information available
Vapor density no data available
Odor
Melting point/range No information available
VOC Content(%) not applicable
No information available.
Autoignition temperature No information available
Physical State @20°C No information availableOdor Threshold
Specific Gravity no data available
Decomposition temperature No information available
No information availableAppearance
solubility
_____________________________________________________________________________________________
No information available.
No information available.
Flash point
Page 31 / 64
Flammability Limits in AirExplosion limits No information available
No information available
_____________________________________________________________________________________________AB108667-CP173219 - 17 beta Estradiol Standard 4 (600 pg/mL) Revision Date 02-Sep-2015
14. TRANSPORT INFORMATION
Stability
Chemical Name LD50 Oral
12. ECOLOGICAL INFORMATION
LD50 Dermal LC50 Inhalation
Incompatible products
Ecotoxicity
Sodium EDTA 10 g/kg ( Rat )
The environmental impact of this product has not been fully investigated.
None known based on information supplied.
11. TOXICOLOGICAL INFORMATION
Chemical Name Toxicity to algae Toxicity to fish Toxicity tomicroorganisms
Toxicity to daphnia andother aquatic invertebrates
Proclin 53 mg/kg ( Rat )
Sodium EDTA 1.01: 72 h Desmodesmussubspicatus mg/L EC50
41: 96 h Lepomismacrochirus mg/L LC50
static 59.8: 96 h Pimephalespromelas mg/L LC50 static
610: 24 h Daphnia magnamg/L EC50
Hazardous decomposition products None known based on information supplied.
Chronic toxicity
13. DISPOSAL CONSIDERATIONS
Stable under recommended storage conditions.
Waste disposal methods This material, as supplied, is not a hazardous waste according to Federal regulations (40CFR 261). This material could become a hazardous waste if it is mixed with or otherwisecomes in contact with a hazardous waste, if chemical additions are made to this material, orif the material is processed or otherwise altered. Consult 40 CFR 261 to determine whetherthe altered material is a hazardous waste. Consult the appropriate state, regional, or localregulations for additional requirements.
Chronic toxicity Repeated contact may cause allergic reactions in very susceptible persons Avoid repeatedexposure
Acute toxicity
Contaminated packaging Do not re-use empty containers.
10. STABILITY AND REACTIVITY
Sensitization As a precaution the product should be treated as a sensitizer.
Hazardous polymerization
Product Information May cause sensitization of susceptible persons.
Hazardous polymerization does not occur.
_____________________________________________________________________________________________
Target Organ Effects None known.
Page 32 / 64
Conditions to avoid None known based on information supplied.
_____________________________________________________________________________________________AB108667-CP173219 - 17 beta Estradiol Standard 4 (600 pg/mL) Revision Date 02-Sep-2015
Clean Water ActThis product does not contain any substances regulated as pollutants pursuant to the Clean Water Act (40 CFR 122.21 and 40CFR 122.42).
SARA 313Section 313 of Title III of the Superfund Amendments and Reauthorization Act of 1986 (SARA). This product does not contain anychemicals which are subject to the reporting requirements of the Act and Title 40 of the Code of Federal Regulations, Part 372.
CERCLAThis material, as supplied, does not contain any substances regulated as hazardous substances under the ComprehensiveEnvironmental Response Compensation and Liability Act (CERCLA) (40 CFR 302) or the Superfund Amendments andReauthorization Act (SARA) (40 CFR 355). There may be specific reporting requirements at the local, regional, or state levelpertaining to releases of this material.
ADR Not dangerous goods
U.S. State Regulations
SARA 311/312 Hazard Categories
California Proposition 65This product does not contain any Proposition 65 chemicals.
Acute Health Hazard yes
U.S. State Right-to-Know Regulations
International Regulations
Chronic Health Hazard no
15. REGULATORY INFORMATION
Fire Hazard
WHMIS Note: This product has been classified in accordance with the hazard criteria of theControlled Products Regulations (CPR) and the MSDS contains all the informationrequired by the CPR.
no
IATA Not dangerous goods
Sudden Release of Pressure Hazard no
U.S. Federal Regulations
_____________________________________________________________________________________________
Reactive Hazard no
Page 33 / 64
DOT Not dangerous goods
_____________________________________________________________________________________________AB108667-CP173219 - 17 beta Estradiol Standard 4 (600 pg/mL) Revision Date 02-Sep-2015
End of MSDS
Revision Note No information available.
Full text of H-Statements referred to under sections 2 and 3H314 - Causes severe skin burns and eye damage H317 - May cause an allergic skin reaction H400 - Very toxic to aquatic lifeH410 - Very toxic to aquatic life with long lasting effects
Hazard statementsH317 - May cause an allergic skin reaction
_____________________________________________________________________________________________
DisclaimerThe information provided in this Safety Data Sheet is correct to the best of our knowledge, information and belief at the date of itspublication. The information given is designed only as a guidance for safe handling, use, processing, storage, transportation, disposaland release and is not to be considered a warranty or quality specification. The information relates only to the specific materialdesignated and may not be valid for such material used in combination with any other materials or in any process, unless specified in thetext.
16. OTHER INFORMATION
Revision Date
Page 34 / 64
02-Sep-2015
Revision Date 02-Sep-2015 Version 4
Safety Data SheetIssuing date no data available
For research use only
Ozone Not applicable
E-mail address [email protected]
GHS Label elements, including precautionary statements
Product name 17 beta Estradiol Standard 5 (2,000 pg/mL)
Emergency telephone Tel: (617)225-2272 or 888-77-ABCAM (22226) (US toll free) - Monday-Friday 8am-9pmEST
Signal WordWarning
Hazard statementsH317 - May cause an allergic skin reaction
1. PRODUCT AND COMPANY IDENTIFICATION
2. HAZARDS IDENTIFICATION
Precautionary Statements - EU (§28, 1272/2008)P302 + P352 - IF ON SKIN: Wash with plenty of soap and waterP261 - Avoid breathing dust/ fume/ gas/ mist/ vapors/ sprayP272 - Contaminated work clothing should not be allowed out of the workplaceP280 - Wear protective gloves/ eye protection/ face protectionP333 + P313 - If skin irritation or rash occurs: Get medical advice/ attentionP363 - Wash contaminated clothing before reuseP501 - Dispose of contents/ container to an approved waste disposal plant
GHS - Classification
Recommended use
Other information
Skin sensitization Category 1
Supplier Address Abcam Inc1 Kendall Square, Ste 341Cambridge, MA 02139-1517USATel: (617)225-2272 or 888-77-ABCAM (22226) (US toll free)Fax: (866) 739-9884 or (866) 457-9616 (both US toll free)
_____________________________________________________________________________________________AB108667-CP173220 - 17 beta Estradiol Standard 5 (2,000 pg/mL) Revision Date 02-Sep-2015
Explosion Data Sensitivity to Mechanical Impact none.
Flammable properties Not flammable.
Sensitivity to Static Discharge none.
No information available
Specific hazards arising from thechemical
Thermal decomposition can lead to release of irritating gases and vapors In the event of fireand/or explosion do not breathe fumes May cause sensitization by inhalation and skincontact
Flash point not determined
Protective equipment andprecautions for firefighters
As in any fire, wear self-contained breathing apparatus pressure-demand, MSHA/NIOSH(approved or equivalent) and full protective gear.
5. FIRE-FIGHTING MEASURES
Suitable extinguishing media Use extinguishing measures that are appropriate to local circumstances and thesurrounding environment.
Move to fresh air.
3. COMPOSITION/INFORMATION ON INGREDIENTS
Sodium EDTA 64-02-8 0.1-1
Ingestion Clean mouth with water. Drink plenty of water.
Eye Dam. 1 (H318) Acute Tox. 4 (H302)
4. FIRST AID MEASURES
Notes to physician May cause sensitization of susceptible persons. Treat symptomatically.
Proclin 55965-84-9 <0.1 Skin Corr. 1B (H314) Skin Sens. 1 (H317)
Aquatic Acute 1 (H400)Aquatic Chronic 1 (H410)
General advice If symptoms persist, call a physician.
Eye contact Immediately flush with plenty of water. After initial flushing, remove any contact lenses andcontinue flushing for at least 15 minutes.
Chemical Name CAS-No
For the full text of the H-Statements mentioned in this Section, see Section 16
Weight %
_____________________________________________________________________________________________
Skin contact Wash off immediately with soap and plenty of water while removing all contaminatedclothes and shoes. May cause an allergic skin reaction. If symptoms persist, call aphysician.
Classification (Reg. 1272/2008)
Page 36 / 64
3.1 Substances
Inhalation
_____________________________________________________________________________________________AB108667-CP173220 - 17 beta Estradiol Standard 5 (2,000 pg/mL) Revision Date 02-Sep-2015
7. HANDLING AND STORAGE
Advice on safe handling Ensure adequate ventilation. Wear personal protective equipment.
Technical measures/Storageconditions
Keep out of the reach of children. Keep container tightly closed. Keep containers tightlyclosed in a cool, well-ventilated place.
Personal precautions
Engineering measures ShowersEyewash stationsVentilation systems
9. PHYSICAL AND CHEMICAL PROPERTIES
Environmental precautions Try to prevent the material from entering drains or water courses.
Methods for cleaning up
Personal protective equipment
Soak up with inert absorbent material. Pick up and transfer to properly labeled containers.After cleaning, flush away traces with water. Prevent product from entering drains.
Use personal protective equipment. Avoid contact with the skin and the eyes.
Eye/face protection Tightly fitting safety goggles.
8. EXPOSURE CONTROLS/PERSONAL PROTECTION
Skin and body protection No special protective equipment required.Respiratory protection If exposure limits are exceeded or irritation is experienced, NIOSH/MSHA approved
respiratory protection should be worn. Positive-pressure supplied air respirators may berequired for high airborne contaminant concentrations. Respiratory protection must beprovided in accordance with current local regulations.
6. ACCIDENTAL RELEASE MEASURES
Hygiene measures When using, do not eat, drink or smoke. Remove and wash contaminated clothing beforere-use.
Exposure Guidelines This product does not contain any hazardous materials with occupational exposure limitsestablished by the region specific regulatory bodies.
Methods for containment Prevent further leakage or spillage if safe to do so.
Boiling point/boiling range
Evaporation rate No information available
No information availableNo information available
pH No information available
Vapor density no data available
Odor
Melting point/range No information available
VOC Content(%) not applicable
No information available.
Autoignition temperature No information available
Physical State @20°C No information availableOdor Threshold
Specific Gravity no data available
Decomposition temperature No information available
No information availableAppearance
solubility
_____________________________________________________________________________________________
No information available.
No information available.
Flash point
Page 37 / 64
Flammability Limits in AirExplosion limits No information available
No information available
_____________________________________________________________________________________________AB108667-CP173220 - 17 beta Estradiol Standard 5 (2,000 pg/mL) Revision Date 02-Sep-2015
14. TRANSPORT INFORMATION
Stability
Chemical Name LD50 Oral
12. ECOLOGICAL INFORMATION
LD50 Dermal LC50 Inhalation
Incompatible products
Ecotoxicity
Sodium EDTA 10 g/kg ( Rat )
The environmental impact of this product has not been fully investigated.
None known based on information supplied.
11. TOXICOLOGICAL INFORMATION
Chemical Name Toxicity to algae Toxicity to fish Toxicity tomicroorganisms
Toxicity to daphnia andother aquatic invertebrates
Proclin 53 mg/kg ( Rat )
Sodium EDTA 1.01: 72 h Desmodesmussubspicatus mg/L EC50
41: 96 h Lepomismacrochirus mg/L LC50
static 59.8: 96 h Pimephalespromelas mg/L LC50 static
610: 24 h Daphnia magnamg/L EC50
Hazardous decomposition products None known based on information supplied.
Chronic toxicity
13. DISPOSAL CONSIDERATIONS
Stable under recommended storage conditions.
Waste disposal methods This material, as supplied, is not a hazardous waste according to Federal regulations (40CFR 261). This material could become a hazardous waste if it is mixed with or otherwisecomes in contact with a hazardous waste, if chemical additions are made to this material, orif the material is processed or otherwise altered. Consult 40 CFR 261 to determine whetherthe altered material is a hazardous waste. Consult the appropriate state, regional, or localregulations for additional requirements.
Chronic toxicity Repeated contact may cause allergic reactions in very susceptible persons Avoid repeatedexposure
Acute toxicity
Contaminated packaging Do not re-use empty containers.
10. STABILITY AND REACTIVITY
Sensitization As a precaution the product should be treated as a sensitizer.
Hazardous polymerization
Product Information May cause sensitization of susceptible persons.
Hazardous polymerization does not occur.
_____________________________________________________________________________________________
Target Organ Effects None known.
Page 38 / 64
Conditions to avoid None known based on information supplied.
_____________________________________________________________________________________________AB108667-CP173220 - 17 beta Estradiol Standard 5 (2,000 pg/mL) Revision Date 02-Sep-2015
Clean Water ActThis product does not contain any substances regulated as pollutants pursuant to the Clean Water Act (40 CFR 122.21 and 40CFR 122.42).
SARA 313Section 313 of Title III of the Superfund Amendments and Reauthorization Act of 1986 (SARA). This product does not contain anychemicals which are subject to the reporting requirements of the Act and Title 40 of the Code of Federal Regulations, Part 372.
CERCLAThis material, as supplied, does not contain any substances regulated as hazardous substances under the ComprehensiveEnvironmental Response Compensation and Liability Act (CERCLA) (40 CFR 302) or the Superfund Amendments andReauthorization Act (SARA) (40 CFR 355). There may be specific reporting requirements at the local, regional, or state levelpertaining to releases of this material.
ADR Not dangerous goods
U.S. State Regulations
SARA 311/312 Hazard Categories
California Proposition 65This product does not contain any Proposition 65 chemicals.
Acute Health Hazard yes
U.S. State Right-to-Know Regulations
International Regulations
Chronic Health Hazard no
15. REGULATORY INFORMATION
Fire Hazard
WHMIS Note: This product has been classified in accordance with the hazard criteria of theControlled Products Regulations (CPR) and the MSDS contains all the informationrequired by the CPR.
no
IATA Not dangerous goods
Sudden Release of Pressure Hazard no
U.S. Federal Regulations
_____________________________________________________________________________________________
Reactive Hazard no
Page 39 / 64
DOT Not dangerous goods
_____________________________________________________________________________________________AB108667-CP173220 - 17 beta Estradiol Standard 5 (2,000 pg/mL) Revision Date 02-Sep-2015
End of MSDS
Revision Note No information available.
Full text of H-Statements referred to under sections 2 and 3H314 - Causes severe skin burns and eye damage H317 - May cause an allergic skin reaction H400 - Very toxic to aquatic lifeH410 - Very toxic to aquatic life with long lasting effects
Hazard statementsH317 - May cause an allergic skin reaction
_____________________________________________________________________________________________
DisclaimerThe information provided in this Safety Data Sheet is correct to the best of our knowledge, information and belief at the date of itspublication. The information given is designed only as a guidance for safe handling, use, processing, storage, transportation, disposaland release and is not to be considered a warranty or quality specification. The information relates only to the specific materialdesignated and may not be valid for such material used in combination with any other materials or in any process, unless specified in thetext.
16. OTHER INFORMATION
Revision Date
Page 40 / 64
02-Sep-2015
Revision Date 02-Sep-2015 Version 6
Safety Data SheetIssuing date no data available
Tel: (617)225-2272 or 888-77-ABCAM (22226) (US toll free) - Monday-Friday 8am-9pmEST
Other information
No information available
1. PRODUCT AND COMPANY IDENTIFICATION
2. HAZARDS IDENTIFICATIONGHS - Classification
Recommended use
Ozone Not applicable
For research use only
E-mail address [email protected]
GHS Label elements, including precautionary statements
Product name Stop Solution
Emergency telephone
Skin Corr. 1A (H314)
3. COMPOSITION/INFORMATION ON INGREDIENTS
Supplier Address
For the full text of the H-Statements mentioned in this Section, see Section 16
3.1 Substances
Abcam Inc1 Kendall Square, Ste 341Cambridge, MA 02139-1517USATel: (617)225-2272 or 888-77-ABCAM (22226) (US toll free)Fax: (866) 739-9884 or (866) 457-9616 (both US toll free)
Chemical Name CAS-No Weight % Classification (Reg. 1272/2008)Sulphuric acid 7664-93-9 1-5
_____________________________________________________________________________________________AB108667-CP91791 - Stop Solution Revision Date 02-Sep-2015
Suitable extinguishing media Use extinguishing measures that are appropriate to local circumstances and thesurrounding environment.
7. HANDLING AND STORAGE
5. FIRE-FIGHTING MEASURES
Advice on safe handling Handle in accordance with good industrial hygiene and safety practice.
Explosion Data
Flash point not determined
Technical measures/Storageconditions
Keep containers tightly closed in a dry, cool and well-ventilated place.
Sensitivity to Mechanical Impact none.
Flammable properties
Sensitivity to Static Discharge none.
Not flammable.
Protective equipment andprecautions for firefighters
As in any fire, wear self-contained breathing apparatus pressure-demand, MSHA/NIOSH(approved or equivalent) and full protective gear.
Personal precautions Ensure adequate ventilation.
Skin contact
Ingestion Clean mouth with water. Drink plenty of water.
Wash off immediately with soap and plenty of water while removing all contaminatedclothes and shoes.
Environmental precautions Try to prevent the material from entering drains or water courses.
Eye contact Immediately flush with plenty of water. After initial flushing, remove any contact lenses andcontinue flushing for at least 15 minutes.
Methods for containment Prevent further leakage or spillage if safe to do so.
Notes to physician Treat symptomatically.
Methods for cleaning up
_____________________________________________________________________________________________
Pick up and transfer to properly labeled containers.
Inhalation
Page 42 / 64
Move to fresh air.
6. ACCIDENTAL RELEASE MEASURES
4. FIRST AID MEASURES
_____________________________________________________________________________________________AB108667-CP91791 - Stop Solution Revision Date 02-Sep-2015
Exposure Guidelines
Respiratory protection If exposure limits are exceeded or irritation is experienced, NIOSH/MSHA approvedrespiratory protection should be worn. Positive-pressure supplied air respirators may berequired for high airborne contaminant concentrations. Respiratory protection must beprovided in accordance with current local regulations.
Chemical Name ACGIH TLV
Other Exposure Guidelines Vacated limits revoked by the Court of Appeals decision in AFL-CIO v. OSHA, 965 F.2d962 (11th Cir., 1992).
Hygiene measures Handle in accordance with good industrial hygiene and safety practice.
OSHA PEL NIOSH IDLH
10. STABILITY AND REACTIVITY
This product does not contain any hazardous materials with occupational exposure limitsestablished by the region specific regulatory bodies.
Stability Stable under recommended storage conditions.
Engineering measures ShowersEyewash stationsVentilation systems
Sulphuric acid 7664-93-9
TWA: 0.2 mg/m3 thoracic fraction
Incompatible products None known based on information supplied.
9. PHYSICAL AND CHEMICAL PROPERTIES
Conditions to avoid None known based on information supplied.
TWA: 1 mg/m3
(vacated) TWA: 1 mg/m3
IDLH: 15 mg/m3
TWA: 1 mg/m3
Hazardous decomposition products None known based on information supplied.
Personal protective equipment
Hazardous polymerization Hazardous polymerization does not occur.
8. EXPOSURE CONTROLS/PERSONAL PROTECTION
Eye/face protection No special protective equipment required.
NIOSH IDLH: Immediately Dangerous to Life or Health
Skin and body protection No special protective equipment required.
Odor
Melting point/range No information available
VOC Content(%) not applicable
No information available.
Autoignition temperature No information available
Physical State @20°C No information availableOdor Threshold
Specific Gravity no data available
Decomposition temperature No information available
No information availableAppearance
solubility No information available.
No information available.
Flash pointBoiling point/boiling range
Evaporation rate No information available
No information availableNo information available
pH
_____________________________________________________________________________________________
No information available
Vapor density no data available
Page 43 / 64
Explosion limits No information availableNo information availableFlammability Limits in Air
_____________________________________________________________________________________________AB108667-CP91791 - Stop Solution Revision Date 02-Sep-2015
14. TRANSPORT INFORMATION
LD50 Dermal
Sulphuric acid A2 Group 1
Chemical Name Toxicity to algae Toxicity to fish Toxicity tomicroorganisms
Toxicity to daphnia andother aquatic invertebrates
Known X
Sulphuric acid 500: 96 h Brachydanio reriomg/L LC50 static
29: 24 h Daphnia magnamg/L EC50
LC50 Inhalation
Product Information
ACGIH: (American Conference of Governmental Industrial Hygienists)A2 - Suspected Human Carcinogen
Product does not present an acute toxicity hazard based on known or supplied information.
Sulphuric acid
IARC: (International Agency for Research on Cancer)Group 1 - Carcinogenic to Humans
13. DISPOSAL CONSIDERATIONS
2140 mg/kg ( Rat )
NTP: (National Toxicity Program)Known - Known Carcinogen
Waste disposal methods This material, as supplied, is not a hazardous waste according to Federal regulations (40CFR 261). This material could become a hazardous waste if it is mixed with or otherwisecomes in contact with a hazardous waste, if chemical additions are made to this material, orif the material is processed or otherwise altered. Consult 40 CFR 261 to determine whetherthe altered material is a hazardous waste. Consult the appropriate state, regional, or localregulations for additional requirements.
510 mg/m3 ( Rat ) 2 h 347 ppm (Rat ) 1 h
OSHA: (Occupational Safety & Health Administration)X - Present
Contaminated packaging Do not re-use empty containers.
Chronic toxicity
This product contains one or more substances that are listed with the State of California as a hazardous waste.
11. TOXICOLOGICAL INFORMATION
Chemical Name California Hazardous Waste Status
Target Organ Effects
Sulphuric acid Toxic Corrosive
Eyes. Respiratory system. Skin. Teeth.
Carcinogenicity This product contains one or more substances which are classified by IARC ascarcinogenic to humans (Group I), probably carcinogenic to humans (Group 2A) or possiblycarcinogenic to humans (Group 2B)
Acute toxicity
Chemical Name
12. ECOLOGICAL INFORMATION
Chemical Name ACGIH
_____________________________________________________________________________________________
IARC NTP
Ecotoxicity
Page 44 / 64
OSHA
LD50 Oral
The environmental impact of this product has not been fully investigated.
_____________________________________________________________________________________________AB108667-CP91791 - Stop Solution Revision Date 02-Sep-2015
CWA - ReportableQuantities
CWA - Toxic Pollutants CWA - Priority Pollutants CWA - HazardousSubstances
Weight % SARA 313 - ThresholdValues %
Sulphuric acid 1000 lb X
IATA
CERCLAThis material, as supplied, does not contain any substances regulated as hazardous substances under the ComprehensiveEnvironmental Response Compensation and Liability Act (CERCLA) (40 CFR 302) or the Superfund Amendments andReauthorization Act (SARA) (40 CFR 355). There may be specific reporting requirements at the local, regional, or state levelpertaining to releases of this material.
Sulphuric acid 7664-93-9 1.5 1.0
Chemical Name Hazardous Substances RQs Extremely Hazardous SubstancesRQs
RQ
Not dangerous goods
15. REGULATORY INFORMATION
Sulphuric acid 1000 lb 1000 lb RQ 1000 lb final RQ RQ 454 kg finalRQ
SARA 311/312 Hazard Categories
U.S. State Regulations
Acute Health Hazard
California Proposition 65This product contains the following Proposition 65 chemicals:
no
U.S. Federal Regulations
Chemical Name CAS-No California Prop. 65
Chronic Health Hazard no
Sulphuric acid 7664-93-9 Carcinogen
U.S. State Right-to-Know Regulations
Fire Hazard
Chemical Name Massachusetts New Jersey Pennsylvania Illinois Rhode Island
no
Sulphuric acid X X X X X
International Regulations
Sudden Release of Pressure Hazard no
SARA 313Section 313 of Title III of the Superfund Amendments and Reauthorization Act of 1986 (SARA). This product contains a chemicalor chemicals which are subject to the reporting requirements of the Act and Title 40 of the Code of Federal Regulations, Part 372:
Chemical Name Carcinogen Status Exposure limits
Reactive Hazard
Sulphuric acid A2 Mexico: TWA 1 mg/m3
no
ADR Not dangerous goods
_____________________________________________________________________________________________
Clean Water ActThis product does not contain any substances regulated as pollutants pursuant to the Clean Water Act (40 CFR 122.21 and 40CFR 122.42).
DOT Not dangerous goods
Page 45 / 64
Chemical Name CAS-No
Chemical Name
_____________________________________________________________________________________________AB108667-CP91791 - Stop Solution Revision Date 02-Sep-2015
WHMIS Note: This product has been classified in accordance with the hazard criteria of theControlled Products Regulations (CPR) and the MSDS contains all the informationrequired by the CPR.
Revision Note No information available.
Full text of H-Statements referred to under sections 2 and 3H314 - Causes severe skin burns and eye damage
_____________________________________________________________________________________________
DisclaimerThe information provided in this Safety Data Sheet is correct to the best of our knowledge, information and belief at the date of itspublication. The information given is designed only as a guidance for safe handling, use, processing, storage, transportation, disposaland release and is not to be considered a warranty or quality specification. The information relates only to the specific materialdesignated and may not be valid for such material used in combination with any other materials or in any process, unless specified in thetext.
Revision Date 02-Sep-2015
Page 46 / 64
16. OTHER INFORMATION
End of MSDS
Revision Date 02-Sep-2015 Version 9
Safety Data SheetIssuing date no data available
For research use only
Ozone Not applicable
E-mail address [email protected]
GHS Label elements, including precautionary statements
Product name 17 beta Estradiol-HRP Conjugate
Emergency telephone Tel: (617)225-2272 or 888-77-ABCAM (22226) (US toll free) - Monday-Friday 8am-9pmEST
Signal WordWarning
Hazard statementsH317 - May cause an allergic skin reaction
1. PRODUCT AND COMPANY IDENTIFICATION
2. HAZARDS IDENTIFICATION
Precautionary Statements - EU (§28, 1272/2008)P302 + P352 - IF ON SKIN: Wash with plenty of soap and waterP333 + P313 - If skin irritation or rash occurs: Get medical advice/ attentionP261 - Avoid breathing dust/ fume/ gas/ mist/ vapors/ sprayP280 - Wear protective gloves/ eye protection/ face protectionP272 - Contaminated work clothing should not be allowed out of the workplaceP363 - Wash contaminated clothing before reuseP501 - Dispose of contents/ container to an approved waste disposal plant
GHS - Classification
Recommended use
Other information
Skin sensitization Category 1
Supplier Address Abcam Inc1 Kendall Square, Ste 341Cambridge, MA 02139-1517USATel: (617)225-2272 or 888-77-ABCAM (22226) (US toll free)Fax: (866) 739-9884 or (866) 457-9616 (both US toll free)
_____________________________________________________________________________________________AB108667-CP91839 - 17 beta Estradiol-HRP Conjugate Revision Date 02-Sep-2015
Sensitivity to Mechanical Impact none.
Flammable properties Not flammable.
Sensitivity to Static Discharge none.
Specific hazards arising from thechemical
Thermal decomposition can lead to release of irritating gases and vapors In the event of fireand/or explosion do not breathe fumes May cause sensitization by inhalation and skincontact
Flash point not determined
Protective equipment andprecautions for firefighters
As in any fire, wear self-contained breathing apparatus pressure-demand, MSHA/NIOSH(approved or equivalent) and full protective gear.
No information available
5. FIRE-FIGHTING MEASURES
Suitable extinguishing media Use extinguishing measures that are appropriate to local circumstances and thesurrounding environment.
Explosion Data
Notes to physician May cause sensitization of susceptible persons. Treat symptomatically.
General advice If symptoms persist, call a physician.
For the full text of the H-Statements mentioned in this Section, see Section 16
Chemical Name
Eye contact Immediately flush with plenty of water. After initial flushing, remove any contact lenses andcontinue flushing for at least 15 minutes.
CAS-No Weight %
Skin contact Wash off immediately with soap and plenty of water while removing all contaminatedclothes and shoes. May cause an allergic skin reaction. If symptoms persist, call aphysician.
Classification (Reg. 1272/2008)
3.1 Substances
3. COMPOSITION/INFORMATION ON INGREDIENTS
Proclin
Inhalation Move to fresh air.
55965-84-9 <0.1
_____________________________________________________________________________________________
Skin Corr. 1B (H314) Skin Sens. 1 (H317)
Aquatic Acute 1 (H400)Aquatic Chronic 1 (H410)
4. FIRST AID MEASURES
Ingestion
Page 48 / 64
Clean mouth with water. Drink plenty of water.
_____________________________________________________________________________________________AB108667-CP91839 - 17 beta Estradiol-HRP Conjugate Revision Date 02-Sep-2015
Technical measures/Storageconditions
Keep out of the reach of children. Keep container tightly closed. Keep containers tightlyclosed in a cool, well-ventilated place.
Advice on safe handling Ensure adequate ventilation. Wear personal protective equipment.
7. HANDLING AND STORAGE
Personal precautions
Engineering measures ShowersEyewash stationsVentilation systems
9. PHYSICAL AND CHEMICAL PROPERTIES
Environmental precautions Try to prevent the material from entering drains or water courses.
Methods for cleaning up
Personal protective equipment
Soak up with inert absorbent material. Pick up and transfer to properly labeled containers.After cleaning, flush away traces with water. Prevent product from entering drains.
Use personal protective equipment. Avoid contact with the skin and the eyes.
Eye/face protection Tightly fitting safety goggles.
8. EXPOSURE CONTROLS/PERSONAL PROTECTION
Skin and body protection No special protective equipment required.Respiratory protection If exposure limits are exceeded or irritation is experienced, NIOSH/MSHA approved
respiratory protection should be worn. Positive-pressure supplied air respirators may berequired for high airborne contaminant concentrations. Respiratory protection must beprovided in accordance with current local regulations.
6. ACCIDENTAL RELEASE MEASURES
Hygiene measures When using, do not eat, drink or smoke. Remove and wash contaminated clothing beforere-use.
Exposure Guidelines This product does not contain any hazardous materials with occupational exposure limitsestablished by the region specific regulatory bodies.
Methods for containment Prevent further leakage or spillage if safe to do so.
Boiling point/boiling range
Evaporation rate No information available
No information availableNo information available
pH No information available
Vapor density no data available
Odor
Melting point/range No information available
VOC Content(%) not applicable
No information available.
Autoignition temperature No information available
Physical State @20°C No information availableOdor Threshold
Specific Gravity no data available
Decomposition temperature No information available
No information availableAppearance
solubility
_____________________________________________________________________________________________
No information available.
No information available.
Flash point
Page 49 / 64
Flammability Limits in AirExplosion limits No information available
No information available
_____________________________________________________________________________________________Revision Date 02-Sep-2015AB108667-CP91839 - 17 beta Estradiol-HRP Conjugate
14. TRANSPORT INFORMATION
IATA Not dangerous goods
DOT Not dangerous goods
Chronic toxicity
Hazardous decomposition products None known based on information supplied.
13. DISPOSAL CONSIDERATIONS
Waste disposal methods This material, as supplied, is not a hazardous waste according to Federal regulations (40CFR 261). This material could become a hazardous waste if it is mixed with or otherwisecomes in contact with a hazardous waste, if chemical additions are made to this material, orif the material is processed or otherwise altered. Consult 40 CFR 261 to determine whetherthe altered material is a hazardous waste. Consult the appropriate state, regional, or localregulations for additional requirements.
Chronic toxicity Repeated contact may cause allergic reactions in very susceptible persons Avoid repeatedexposure
Stable under recommended storage conditions.
Contaminated packaging Do not re-use empty containers.
Acute toxicity
Sensitization As a precaution the product should be treated as a sensitizer.
10. STABILITY AND REACTIVITY
Hazardous polymerization
Product Information
Target Organ Effects None known.
May cause sensitization of susceptible persons.
Hazardous polymerization does not occur.
Conditions to avoid None known based on information supplied.
Stability
12. ECOLOGICAL INFORMATION
Chemical Name LD50 Oral LD50 Dermal LC50 Inhalation
Ecotoxicity
Incompatible products
_____________________________________________________________________________________________
The environmental impact of this product has not been fully investigated.
Proclin 53 mg/kg ( Rat )
Page 50 / 64
None known based on information supplied.
11. TOXICOLOGICAL INFORMATION
_____________________________________________________________________________________________AB108667-CP91839 - 17 beta Estradiol-HRP Conjugate Revision Date 02-Sep-2015
no
U.S. State Regulations
U.S. Federal Regulations
Fire Hazard
California Proposition 65This product does not contain any Proposition 65 chemicals.
no
U.S. State Right-to-Know Regulations
Sudden Release of Pressure Hazard no
International Regulations
Not dangerous goods
15. REGULATORY INFORMATION
Reactive Hazard no
SARA 311/312 Hazard Categories
WHMIS Note: This product has been classified in accordance with the hazard criteria of theControlled Products Regulations (CPR) and the MSDS contains all the informationrequired by the CPR.
Clean Water ActThis product does not contain any substances regulated as pollutants pursuant to the Clean Water Act (40 CFR 122.21 and 40CFR 122.42).
Acute Health Hazard
_____________________________________________________________________________________________
yes
ADR
CERCLAThis material, as supplied, does not contain any substances regulated as hazardous substances under the ComprehensiveEnvironmental Response Compensation and Liability Act (CERCLA) (40 CFR 302) or the Superfund Amendments andReauthorization Act (SARA) (40 CFR 355). There may be specific reporting requirements at the local, regional, or state levelpertaining to releases of this material.
Page 51 / 64
SARA 313Section 313 of Title III of the Superfund Amendments and Reauthorization Act of 1986 (SARA). This product does not contain anychemicals which are subject to the reporting requirements of the Act and Title 40 of the Code of Federal Regulations, Part 372.
Chronic Health Hazard
_____________________________________________________________________________________________AB108667-CP91839 - 17 beta Estradiol-HRP Conjugate Revision Date 02-Sep-2015
End of MSDS
Revision Note No information available.
Full text of H-Statements referred to under sections 2 and 3H314 - Causes severe skin burns and eye damage H317 - May cause an allergic skin reaction H400 - Very toxic to aquatic lifeH410 - Very toxic to aquatic life with long lasting effects
Hazard statementsH317 - May cause an allergic skin reaction
_____________________________________________________________________________________________
DisclaimerThe information provided in this Safety Data Sheet is correct to the best of our knowledge, information and belief at the date of itspublication. The information given is designed only as a guidance for safe handling, use, processing, storage, transportation, disposaland release and is not to be considered a warranty or quality specification. The information relates only to the specific materialdesignated and may not be valid for such material used in combination with any other materials or in any process, unless specified in thetext.
16. OTHER INFORMATION
Revision Date
Page 52 / 64
02-Sep-2015
Revision Date 02-Sep-2015 Version 6
Safety Data SheetIssuing date no data available
Ozone Not applicable
For research use only
E-mail address [email protected]
GHS Label elements, including precautionary statements
Not dangerous
Product name TMB Substrate Solution
Emergency telephone Tel: (617)225-2272 or 888-77-ABCAM (22226) (US toll free) - Monday-Friday 8am-9pmEST
Other information
1. PRODUCT AND COMPANY IDENTIFICATION
2. HAZARDS IDENTIFICATION
Avoid contact with DMSO solutions containing toxic materials or materials with unknown toxicological properties. DMSO is readilyabsorbed through skin and may carry such materials into the body.
GHS - Classification
Recommended use
Supplier Address Abcam Inc1 Kendall Square, Ste 341Cambridge, MA 02139-1517USATel: (617)225-2272 or 888-77-ABCAM (22226) (US toll free)Fax: (866) 739-9884 or (866) 457-9616 (both US toll free)
_____________________________________________________________________________________________Revision Date 02-Sep-2015AB108667-CP91840 - TMB Substrate Solution
Sensitivity to Mechanical Impact none.
Flash point not determined
Sensitivity to Static Discharge none.
Protective equipment andprecautions for firefighters
As in any fire, wear self-contained breathing apparatus pressure-demand, MSHA/NIOSH(approved or equivalent) and full protective gear.
Flammable properties
Suitable extinguishing media Use extinguishing measures that are appropriate to local circumstances and thesurrounding environment.
Not flammable.
5. FIRE-FIGHTING MEASURES
Explosion Data
Chemical Name CAS-No
Inhalation Move to fresh air.
Weight % Classification (Reg. 1272/2008)
For the full text of the H-Statements mentioned in this Section, see Section 16
3.1 Substances
Ingestion Clean mouth with water. Drink plenty of water.
3. COMPOSITION/INFORMATION ON INGREDIENTS
DMSO
Notes to physician Treat symptomatically.
67-68-5 3-7
TMB 54827-17-7
4. FIRST AID MEASURES
<0.1 STOT SE 3 (H335) Skin Irrit. 2 (H315) Eye Irrit. 2 (H319)
Eye contact
_____________________________________________________________________________________________
Immediately flush with plenty of water. After initial flushing, remove any contact lenses andcontinue flushing for at least 15 minutes.
Hydrogen peroxide 7722-84-1
Page 54 / 64
<0.1 Acute Tox. 4 (H302) Acute Tox. 4 (H332)Skin Corr. 1A (H314) Eye Dam. 1 (H318)
Skin contact Wash off immediately with soap and plenty of water while removing all contaminatedclothes and shoes.
_____________________________________________________________________________________________Revision Date 02-Sep-2015AB108667-CP91840 - TMB Substrate Solution
Advice on safe handling Handle in accordance with good industrial hygiene and safety practice.
7. HANDLING AND STORAGE
Technical measures/Storageconditions
Keep containers tightly closed in a dry, cool and well-ventilated place.
Engineering measures ShowersEyewash stationsVentilation systems
6. ACCIDENTAL RELEASE MEASURES
Exposure Guidelines This product does not contain any hazardous materials with occupational exposure limitsestablished by the region specific regulatory bodies.
Personal protective equipment
Methods for containment Prevent further leakage or spillage if safe to do so.
Eye/face protection No special protective equipment required.Skin and body protection No special protective equipment required.
Personal precautions
Chemical Name
Respiratory protection If exposure limits are exceeded or irritation is experienced, NIOSH/MSHA approvedrespiratory protection should be worn. Positive-pressure supplied air respirators may berequired for high airborne contaminant concentrations. Respiratory protection must beprovided in accordance with current local regulations.
ACGIH TLV OSHA PEL NIOSH IDLH
Hygiene measures Handle in accordance with good industrial hygiene and safety practice.
Environmental precautions
Hydrogen peroxide 7722-84-1
TWA: 1 ppm TWA: 1 ppm TWA: 1.4 mg/m3
(vacated) TWA: 1 ppm (vacated)TWA: 1.4 mg/m3
IDLH: 75 ppmTWA: 1 ppm TWA: 1.4 mg/m3
Try to prevent the material from entering drains or water courses.
Methods for cleaning up
NIOSH IDLH: Immediately Dangerous to Life or Health
Pick up and transfer to properly labeled containers.
Ensure adequate ventilation.
_____________________________________________________________________________________________
8. EXPOSURE CONTROLS/PERSONAL PROTECTION
Other Exposure Guidelines Vacated limits revoked by the Court of Appeals decision in AFL-CIO v. OSHA, 965 F.2d962 (11th Cir., 1992).
Page 55 / 64
_____________________________________________________________________________________________AB108667-CP91840 - TMB Substrate Solution Revision Date 02-Sep-2015
Product Information Product does not present an acute toxicity hazard based on known or supplied information.
Incompatible products None known based on information supplied.
Chemical Name LD50 Oral LD50 Dermal LC50 InhalationDMSO 14500 mg/kg ( Rat ) 40 g/kg ( Rat )
Hydrogen peroxide 801 mg/kg ( Rat ) 4060 mg/kg ( Rat ) 2000 mg/kg (Rabbit )
2 mg/L ( Rat ) 4 h
Conditions to avoid None known based on information supplied.
Chronic toxicity
Carcinogenicity This product contains one or more substances which are classified by IARC ascarcinogenic to humans (Group I), probably carcinogenic to humans (Group 2A) or possiblycarcinogenic to humans (Group 2B)
Hazardous decomposition products None known based on information supplied.
Chemical Name ACGIH IARC NTP OSHAHydrogen peroxide A3 Group 3
9. PHYSICAL AND CHEMICAL PROPERTIES
Hazardous polymerization Hazardous polymerization does not occur.
Target Organ Effects None known.
10. STABILITY AND REACTIVITY
11. TOXICOLOGICAL INFORMATION
Acute toxicity
Stability Stable under recommended storage conditions.
Appearance
solubility No information available.
No information available.
Flash pointBoiling point/boiling range
Evaporation rate No information available
No information availableNo information available
pH No information available
Vapor density no data available
Odor
Melting point/range No information available
VOC Content(%) 5
No information available.
Autoignition temperature No information available
Physical State @20°C No information availableOdor Threshold
Specific Gravity
_____________________________________________________________________________________________
no data available
Decomposition temperature No information available
No information available
Page 56 / 64
No information availableNo information availableFlammability Limits in Air
Explosion limits
_____________________________________________________________________________________________AB108667-CP91840 - TMB Substrate Solution Revision Date 02-Sep-2015
IATA
SARA 313Section 313 of Title III of the Superfund Amendments and Reauthorization Act of 1986 (SARA). This product does not contain anychemicals which are subject to the reporting requirements of the Act and Title 40 of the Code of Federal Regulations, Part 372.
Not dangerous goods
SARA 311/312 Hazard Categories Acute Health Hazard no
14. TRANSPORT INFORMATION
ADR
Chronic Health Hazard no
Not dangerous goods
Fire Hazard no
DOT
Sudden Release of Pressure Hazard no
Not dangerous goods
15. REGULATORY INFORMATIONU.S. Federal Regulations
13. DISPOSAL CONSIDERATIONS
34: 96 h Pimephalespromelas mg/L LC50 33-37:96 h Oncorhynchus mykiss
g/L LC50 static 40: 96 hLepomis macrochirus g/L
LC50 static 41.7: 96 hCyprinus carpio g/L LC50
7000: 24 h Daphnia speciesmg/L EC50
Waste disposal methods This material, as supplied, is not a hazardous waste according to Federal regulations (40CFR 261). This material could become a hazardous waste if it is mixed with or otherwisecomes in contact with a hazardous waste, if chemical additions are made to this material, orif the material is processed or otherwise altered. Consult 40 CFR 261 to determine whetherthe altered material is a hazardous waste. Consult the appropriate state, regional, or localregulations for additional requirements.
Ecotoxicity
Hydrogen peroxide 2.5: 72 h Chlorella vulgarismg/L EC50
16.4: 96 h Pimephalespromelas mg/L LC50 18-56:96 h Lepomis macrochirusmg/L LC50 static 10.0-32.0:96 h Oncorhynchus mykiss
mg/L LC50 static
Contaminated packaging Do not re-use empty containers.
7.7: 24 h Daphnia magnamg/L EC50 18 - 32: 48 h
Daphnia magna mg/L EC50Static
This product contains one or more substances that are listed with the State of California as a hazardous waste.
Chemical Name log Pow
Chemical Name
Chemical Name California Hazardous Waste Status
DMSO -2.03
Hydrogen peroxide Toxic Corrosive Ignitable Reactive
_____________________________________________________________________________________________
Toxicity to algae Toxicity to fish Toxicity tomicroorganisms
Toxicity to daphnia andother aquatic invertebrates
Page 57 / 64
12. ECOLOGICAL INFORMATION
The environmental impact of this product has not been fully investigated.
DMSO 12350 - 25500: 96 hSkeletonema costatum mg/L
EC50
_____________________________________________________________________________________________AB108667-CP91840 - TMB Substrate Solution Revision Date 02-Sep-2015
Chemical Name Carcinogen Status Exposure limitsHydrogen peroxide A3 Mexico: TWA 1 ppm Mexico: TWA 1.5
mg/m3
Mexico: STEL 2 ppm Mexico: STEL 3mg/m3
California Proposition 65This product does not contain any Proposition 65 chemicals.
Chemical Name Hazardous Substances RQs
WHMIS Note: This product has been classified in accordance with the hazard criteria of theControlled Products Regulations (CPR) and the MSDS contains all the informationrequired by the CPR.
Extremely Hazardous SubstancesRQs
RQ
U.S. State Right-to-Know Regulations
no
Chemical Name Massachusetts New Jersey Pennsylvania Illinois Rhode Island
Hydrogen peroxide
DMSO X
1000 lb
Hydrogen peroxide X X X X
CERCLAThis material, as supplied, does not contain any substances regulated as hazardous substances under the ComprehensiveEnvironmental Response Compensation and Liability Act (CERCLA) (40 CFR 302) or the Superfund Amendments andReauthorization Act (SARA) (40 CFR 355). There may be specific reporting requirements at the local, regional, or state levelpertaining to releases of this material.
Clean Water ActThis product does not contain any substances regulated as pollutants pursuant to the Clean Water Act (40 CFR 122.21 and 40CFR 122.42).
International Regulations
U.S. State Regulations
Reactive Hazard
Revision Note No information available.
Full text of H-Statements referred to under sections 2 and 3H302 - Harmful if swallowed H332 - Harmful if inhaled H335 - May cause respiratory irritation H314 - Causes severe skin burnsand eye damage H318 - Causes serious eye damage H319 - Causes serious eye irritation H315 - Causes skin irritation
_____________________________________________________________________________________________
DisclaimerThe information provided in this Safety Data Sheet is correct to the best of our knowledge, information and belief at the date of itspublication. The information given is designed only as a guidance for safe handling, use, processing, storage, transportation, disposaland release and is not to be considered a warranty or quality specification. The information relates only to the specific materialdesignated and may not be valid for such material used in combination with any other materials or in any process, unless specified in thetext.
Revision Date 02-Sep-2015
Page 58 / 64
16. OTHER INFORMATION
End of MSDS
Revision Date 02-Sep-2015 Version 8
Safety Data SheetIssuing date no data available
For research use only
Ozone Not applicable
E-mail address [email protected]
GHS Label elements, including precautionary statements
Product name 17 beta Estradiol Standard 0
Emergency telephone Tel: (617)225-2272 or 888-77-ABCAM (22226) (US toll free) - Monday-Friday 8am-9pmEST
Signal WordWarning
Hazard statementsH317 - May cause an allergic skin reaction
1. PRODUCT AND COMPANY IDENTIFICATION
2. HAZARDS IDENTIFICATIONGHS - Classification
_____________________________________________________________________________________________
Recommended use
Page 59 / 64
Skin sensitization Category 1
Abcam Inc1 Kendall Square, Ste 341Cambridge, MA 02139-1517USATel: (617)225-2272 or 888-77-ABCAM (22226) (US toll free)Fax: (866) 739-9884 or (866) 457-9616 (both US toll free)
Supplier Address
_____________________________________________________________________________________________Revision Date 02-Sep-2015AB108667-CP91842 - 17 beta Estradiol Standard 0
Flammable properties Not flammable.
No information available
Other information
Flash point not determined
Suitable extinguishing media Use extinguishing measures that are appropriate to local circumstances and thesurrounding environment.
5. FIRE-FIGHTING MEASURES
Precautionary Statements - EU (§28, 1272/2008)P302 + P352 - IF ON SKIN: Wash with plenty of soap and waterP333 + P313 - If skin irritation or rash occurs: Get medical advice/ attentionP261 - Avoid breathing dust/ fume/ gas/ mist/ vapors/ sprayP280 - Wear protective gloves/ eye protection/ face protectionP272 - Contaminated work clothing should not be allowed out of the workplaceP363 - Wash contaminated clothing before reuseP501 - Dispose of contents/ container to an approved waste disposal plant
55965-84-9 <0.1 Skin Corr. 1B (H314) Skin Sens. 1 (H317)
Aquatic Acute 1 (H400)Aquatic Chronic 1 (H410)
General advice If symptoms persist, call a physician.
Eye contact Immediately flush with plenty of water. After initial flushing, remove any contact lenses andcontinue flushing for at least 15 minutes.
Chemical Name CAS-No
For the full text of the H-Statements mentioned in this Section, see Section 16
Weight %
Skin contact Wash off immediately with soap and plenty of water while removing all contaminatedclothes and shoes. May cause an allergic skin reaction. If symptoms persist, call aphysician.
Classification (Reg. 1272/2008)
3.1 Substances
Inhalation Move to fresh air.
3. COMPOSITION/INFORMATION ON INGREDIENTS
Sodium EDTA 64-02-8 0.1-1
Ingestion Clean mouth with water. Drink plenty of water.
_____________________________________________________________________________________________
Eye Dam. 1 (H318) Acute Tox. 4 (H302)
Page 60 / 64
4. FIRST AID MEASURES
Notes to physician May cause sensitization of susceptible persons. Treat symptomatically.
Proclin
_____________________________________________________________________________________________Revision Date 02-Sep-2015AB108667-CP91842 - 17 beta Estradiol Standard 0
Thermal decomposition can lead to release of irritating gases and vapors In the event of fireand/or explosion do not breathe fumes May cause sensitization by inhalation and skincontact
Sensitivity to Static Discharge
Technical measures/Storageconditions
Keep out of the reach of children. Keep container tightly closed. Keep containers tightlyclosed in a cool, well-ventilated place.
none.
Explosion Data
Protective equipment andprecautions for firefighters
As in any fire, wear self-contained breathing apparatus pressure-demand, MSHA/NIOSH(approved or equivalent) and full protective gear.
Sensitivity to Mechanical Impact
7. HANDLING AND STORAGE
none.
Advice on safe handling Ensure adequate ventilation. Wear personal protective equipment.
Specific hazards arising from thechemical
Eye/face protection Tightly fitting safety goggles.
8. EXPOSURE CONTROLS/PERSONAL PROTECTION
Skin and body protection No special protective equipment required.Respiratory protection If exposure limits are exceeded or irritation is experienced, NIOSH/MSHA approved
respiratory protection should be worn. Positive-pressure supplied air respirators may berequired for high airborne contaminant concentrations. Respiratory protection must beprovided in accordance with current local regulations.
6. ACCIDENTAL RELEASE MEASURES
Hygiene measures When using, do not eat, drink or smoke. Remove and wash contaminated clothing beforere-use.
Exposure Guidelines This product does not contain any hazardous materials with occupational exposure limitsestablished by the region specific regulatory bodies.
Methods for containment Prevent further leakage or spillage if safe to do so.
Personal precautions
Engineering measures ShowersEyewash stationsVentilation systems
Environmental precautions
_____________________________________________________________________________________________
Try to prevent the material from entering drains or water courses.
Methods for cleaning up
Personal protective equipment
Page 61 / 64
Soak up with inert absorbent material. Pick up and transfer to properly labeled containers.After cleaning, flush away traces with water. Prevent product from entering drains.
Use personal protective equipment. Avoid contact with the skin and the eyes.
_____________________________________________________________________________________________AB108667-CP91842 - 17 beta Estradiol Standard 0 Revision Date 02-Sep-2015
Product Information May cause sensitization of susceptible persons.
Incompatible products None known based on information supplied.
Chemical Name LD50 Oral LD50 Dermal LC50 InhalationSodium EDTA 10 g/kg ( Rat )
Proclin 53 mg/kg ( Rat )
Conditions to avoid None known based on information supplied.
Chronic toxicity
Chronic toxicity Repeated contact may cause allergic reactions in very susceptible persons Avoid repeatedexposure
Hazardous decomposition products None known based on information supplied.
Sensitization As a precaution the product should be treated as a sensitizer.
9. PHYSICAL AND CHEMICAL PROPERTIES
Hazardous polymerization Hazardous polymerization does not occur.
Target Organ Effects None known.
10. STABILITY AND REACTIVITY
11. TOXICOLOGICAL INFORMATION
Acute toxicity
Stability Stable under recommended storage conditions.
Odor Threshold
Specific Gravity no data available
Decomposition temperature No information available
No information availableAppearance
solubility No information available.
No information available.
Flash pointBoiling point/boiling range
Evaporation rate No information available
No information availableNo information available
pH No information available
Vapor density no data available
Odor
Melting point/range No information available
VOC Content(%) not applicable
No information available.
Autoignition temperature
_____________________________________________________________________________________________
No information available
Physical State @20°C No information available
Page 62 / 64
No information availableFlammability Limits in AirExplosion limits No information available
_____________________________________________________________________________________________AB108667-CP91842 - 17 beta Estradiol Standard 0 Revision Date 02-Sep-2015
yes
14. TRANSPORT INFORMATION
ADR
Chronic Health Hazard no
Not dangerous goods
Fire Hazard no
DOT
Sudden Release of Pressure Hazard no
Not dangerous goods
Reactive Hazard no
15. REGULATORY INFORMATIONU.S. Federal Regulations
Clean Water ActThis product does not contain any substances regulated as pollutants pursuant to the Clean Water Act (40 CFR 122.21 and 40CFR 122.42).
CERCLAThis material, as supplied, does not contain any substances regulated as hazardous substances under the ComprehensiveEnvironmental Response Compensation and Liability Act (CERCLA) (40 CFR 302) or the Superfund Amendments andReauthorization Act (SARA) (40 CFR 355). There may be specific reporting requirements at the local, regional, or state levelpertaining to releases of this material.
IATA
SARA 313Section 313 of Title III of the Superfund Amendments and Reauthorization Act of 1986 (SARA). This product does not contain anychemicals which are subject to the reporting requirements of the Act and Title 40 of the Code of Federal Regulations, Part 372.
Not dangerous goods
U.S. State Regulations
SARA 311/312 Hazard Categories Acute Health Hazard
Toxicity tomicroorganisms
Toxicity to daphnia andother aquatic invertebrates
12. ECOLOGICAL INFORMATION
The environmental impact of this product has not been fully investigated.
Waste disposal methods This material, as supplied, is not a hazardous waste according to Federal regulations (40CFR 261). This material could become a hazardous waste if it is mixed with or otherwisecomes in contact with a hazardous waste, if chemical additions are made to this material, orif the material is processed or otherwise altered. Consult 40 CFR 261 to determine whetherthe altered material is a hazardous waste. Consult the appropriate state, regional, or localregulations for additional requirements.
Sodium EDTA 1.01: 72 h Desmodesmussubspicatus mg/L EC50
41: 96 h Lepomismacrochirus mg/L LC50
static 59.8: 96 h Pimephalespromelas mg/L LC50 static
Contaminated packaging Do not re-use empty containers.
610: 24 h Daphnia magnamg/L EC50
_____________________________________________________________________________________________
Ecotoxicity
Page 63 / 64
Chemical Name Toxicity to algae Toxicity to fish
13. DISPOSAL CONSIDERATIONS
_____________________________________________________________________________________________AB108667-CP91842 - 17 beta Estradiol Standard 0 Revision Date 02-Sep-2015
California Proposition 65This product does not contain any Proposition 65 chemicals.
U.S. State Right-to-Know Regulations
International Regulations
WHMIS Note: This product has been classified in accordance with the hazard criteria of theControlled Products Regulations (CPR) and the MSDS contains all the informationrequired by the CPR.
End of MSDS
Revision Note No information available.
Full text of H-Statements referred to under sections 2 and 3H314 - Causes severe skin burns and eye damage H317 - May cause an allergic skin reaction H400 - Very toxic to aquatic lifeH410 - Very toxic to aquatic life with long lasting effects H318 - Causes serious eye damage H302 - Harmful if swallowed
Hazard statementsH317 - May cause an allergic skin reaction
_____________________________________________________________________________________________
DisclaimerThe information provided in this Safety Data Sheet is correct to the best of our knowledge, information and belief at the date of itspublication. The information given is designed only as a guidance for safe handling, use, processing, storage, transportation, disposaland release and is not to be considered a warranty or quality specification. The information relates only to the specific materialdesignated and may not be valid for such material used in combination with any other materials or in any process, unless specified in thetext.
16. OTHER INFORMATION
Revision Date
Page 64 / 64
02-Sep-2015