1

Khandesh College Education Society’s

Moolji Jaitha College, Jalgaon

An “Autonomous College”Affiliated to

KBC North Maharashtra University, Jalgaon

SYLLABUS STRUCTURE OF

M. Sc. Chemistry

Under Choice Based Credit System (CBCS)

[w. e. f. Academic Year: 2019-20]

2

M. Sc. I Organic and Analytical Chemistry Course Structure

Term /

Semester

Course

Module

Subject

Code Title of Paper Credit

Hours

per

Week

I

DSC CH- 101 Physical Chemistry-I 4 4

DSC CH- 102 Inorganic Chemistry-I 4 4

DSC CH- 103 Physical Chemistry Practical 4 8

DSC CH- 104 Inorganic Chemistry Practical 4 8

SEC CH- 105 Laboratory planning and safety 4 4

DSE CH- 106 Organic Chemistry-I 4 4

II

DSC CH- 201 Physical Chemistry-II, 4 4

DSC CH- 202 Inorganic Chemistry-II 4 4

DSC CH- 203 Organic Chemistry practical 4 8

DSC CH- 204 Analytical Chemistry practical 4 8

GE CH-205 Analysis and monitoring of

Environmental Pollution 4

4

DSE CH- 206 Organic Chemistry-II 4 4

M. Sc. II Organic Chemistry Course Structure

3

Term /

Semester

Course

Module

Subject

Code Title of Paper Credit

Hours per

Week

III

DSC CHO-301 Organic Reaction Mechanism 4 4

DSC CHO-302 Stereochemistry 4 4

DSC CHO-303 Lab Course- CHO-I 4 8

DSC CHO-304 Lab Course- CHO-II 4 8

SEC CHO-305 A

OR CHO-305 B

A- Physical methods in

structure determination

OR

B- Advanced reaction

mechanism

4

4

DSE CHO-306 Pericyclic reaction ,free radical

and Photochemistry 4

4

IV

DSC CHO-401 Natural Product 4 4

DSC CHO-402

Molecular modeling and drug

design 4 4

DSC CHO-403

Lab Course- CHO-III

4 8

DSC CHO-404 Research Project - CHO-IV 4 8

GE CHO-405 A

OR

CHO-405 B

A-Research methodology

OR

B-Bio organic chemistry

4 4

4

4

DSE CHO-406 Hetero and Medicinal

chemistry 4

4

M. Sc. II Analytical Chemistry Course Structure

4

Term /

Semester

Course

Module

Subject

Code Title of Paper Credit

Hours

per

Week

III

DSC CHA-301 Concepts of Analytical Chemistry 4 4

DSC CHA-302 Modern Separation Science 4 4

DSC CHA-303 Lab Course- CH A-I 4 8

DSC CHA-304 Lab Course- CH A-II 4 8

SEC

CHA-305 A

OR CHA -305 B

A)Pharmaceutical Analysis

OR

B) Bio-Analysis and Analysis of

Food

4

4

DSE CHA-306 Instrumental Methods of Analysis 4 4

IV

DSC

CHA-401

Spectroscopic Methods of

Analysis 4 4

DSC

CHA-402

Special Analytical Methods and

Analysis of Complex Materials 4 4

DSC CHA-403 Lab Course-CHA-III 4 8

DSC CHA-404 Research Project- CHA–IV– 4 8

GE CHA-405 A- Environmental Analytical

Chemistry

B- Analysis of Organics and

Medicinal

4 4

DSE CHA-406 Applications of Nanotechnology 4 4

Examination Pattern for the all Courses (60: 40)

Nature Marks

External Marks 60

Internal Marks 40

Total Marks 100

1

Khandesh College Education Society’s

Moolji Jaitha College, Jalgaon

An “Autonomous College”Affiliated to

KBC North Maharashtra University, Jalgaon

SYLLABUS

Chemistry (Organic/Analytical)

M. Sc. I

(Semester I& II)

Under Choice Based Credit System (CBCS)

[w. e. f. Academic Year: 2019-20]

1

2

M. Sc. Part I Organic and Analytical Chemistry

SEMESTER I

CH-101 Physical Chemistry-I (4 Credits, 60L)

Objectives:

1. To study the theories and basic concepts of quantum mechanics.

2. To study the Partial molar property, fugacity and its significance.

3. To study the statistical entropy and partition functions.

4. To study the adsorption phenomenon.

Course Outcome:

After successful completion of the course the students :

1. Can understand wave function, operator and quantum mechanical properties and

rigid rotator.

2. Can study concept of partial molar properties and third law of thermodynamics.

3. Can know the partition function and application of statistical thermodynamics.

4. Can understand the surface phenomenon and adsorption types.

1. Quantum Mechanics (20L)

Introduction of Quantum mechanics, wave function, acceptability of wave functions, normalized

and orthogonal wave functions, Operators, Operator algebra, Eigen functions and Eigen values

Quantum mechanical properties linear, Angular momentum, Hermitian operators, Orbital and

generalized angular momentum, Postulates of Quantum mechanics, Problems on operator

algebra, Eigen values and Average values of quantities.

Application of Schrodinger wave equation to simple systems: Degeneracy in 3-Dimensional

Box, Rigid rotor, Potential well of finite depth (Tunneling Effect), Simple Harmonic Oscillator,

The Hydrogen atom.

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2. Thermodynamics (15L)

State functions, exact and inexact differentials, test of exactness. Brief resume of the concept of

enthalpy, entropy, free energy and laws of thermodynamics.

Partial molar properties, Chemical potential, Effect of temperature and pressure, Determination

of partial molar properties by: (1) Direct Method, (ii) Apparent method, (iii) Method of intercept.

Concept of fugacity and its determination by (i) Graphical method, (ii) From equation of

state(iii) Approximation method, Nernst heat theorem and its application to solid, Third law of

thermodynamics, Experimental determination of entropy by third law.

3. Statistical Thermodynamics (15L)

Statistical entropy, microcanonical and canonical ensembles, Maxwell-Boltzmann distribution,

Thermodynamic quantities and canonical partition function, molecular partition functions,

translational, rotational, vibrational and electronic partition functions. Ideal monoatomic and

diatomic gases. Heat capacities - Einstein theory and Debye theory. Applications of statistical

thermodynamics to activated complex theory.

4. Adsorption and Surface phenomenon (10L)

Physisorption and chemisorptions , adsorption isotherms, Langmuir and B. E. T. equation and

significance in surface area determination, surface films, states of insoluble films, L. B. films and

their application, adsorption from solution, adsorption types, surface excess concentration ,

Gibb's adsorption equation :derivation , significance and experimental verification , catalytic

activity of surfaces. Micelles – Surface active agents, classification. Micelles, process of Micellisation, CMC, factors

affecting CMC, thermodynamics of micellisation, cleansing action of soap and detergent.

References:

1. I.N. Levine, Quantum Chemistry, 2000, 5th

edition, Pearson educ., Inc.New Delhi.

2. A.K.Chandra, Introductory Quantum Chemistry, 1994, 4th

edition, Hill, New Delhi.

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4

3. L. Pualing and E. B. Wilson, Introduction to Quantum Mechanics with Applications to

Chemistry, 1935, McGraw Hill, New York

4. R. K. Prasad, Quantum Chemistry, New Age International, Delhi.

5. R. K. Prasad, Quantum Chemistry through problems and solutions, 2009,New Age

International, Delhi.

6. B. C. Reed, Jones and Bartlett, Quantum Mechanics, 2010, New Delhi.

7. R. P. Rastogi and R. R. Mishra, An Introduction to Chemical Thermodynamics,2010,

Vikas Publication, Gorakhpur

8. P. W. Atkins’and D. Paula, Physical Chemistry, 2010, 8th Edition, Oxford University

Press

9. G. K. Vemulapalli, Physical Chemistry, 1997, Prentice– Hall of India.

10. A. W. Adamson, Physical chemistry of surfaces

11. A. Clark, Theory of adsorption and catalysis.

12. B. M. W. Trapnell and H.O. Hayward, Chemisorption,

13. D. J. Shaw, Introduction to colloide and surface chemistry.

14. A. J. K. laidler, Theories of chemical reaction rates.

15. J. J. Bikermann, Surface chemistry.

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CH- 102 Inorganic chemistry-I(4 Credits, 60L)

Learning Objective:

1. To study Wave mechanics wave nature of the electron. 2. To understand the Electronic spectra and magnetic properties of Transition metal complexes 3. To know General properties of metals. 4. To study the interpretation on Orientation of bonds. 5. To study Infrared and Raman Spectroscopy techniques.

Course Outcome:

After successful completion of the course the students :

1.Can understand nature of electron in an atom.

2. Can apply concept of metallurgy. 3. Can understand electronic properties using spectral data. 4. Can apply concept of Hybridization and wave mechanical description 5. Gain the concepts of Vibrations in simple molecules

1. Wave mechanics (10L)

Origin of quantum theory, black body radiation, atomic spectra, photoelectric effect, matter

waves, wave nature of the electron, the wave equation, the theory of hydrogen atom, particle in

one dimensional box.

2. The Metallic bond (10L)

General properties of metals, conductivity, Luster, malleability and cohesive force. Theories of

Bonding in metals – free electron theory, valence bond theory, molecular orbital or band theory.

Conductors, Insulators and semiconductors; Alloys – interstitial alloys and related compounds,

alloys, Cu / Ni (Phase diagram expected), super conductivity.

3. Inorganic Stereochemistry (10L)

Hybridization and wave mechanical description for sp, sp2, sp

3orbital, qualitative idea about

dsp2,dsp

3 and d2sp

3, VSEPR theory, shapes of simple molecules like N2O, F2O, ICl2, PCl5, ClF3,

SF6, IF7, TeCl4, XeOF4, XeF6, Linnet's double quartet theory and spectra of simple molecules.

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6

4. Electronic spectra and magnetic properties of Transition metal complexes (15L)

Spectroscopic ground states, correlation, Orgal and Tanabe-Sugano diagrams for transition metal

complexes (d1-d9 states), calculation of Dq B and β parameters, charge transfer spectra,

spectroscopic method of assignment of absolute configuration in optically active metal chelates

and their steriochemical information, anomalous magnetic moments, magnetic exchange

coupling and spin crossover.

5. Infrared and Raman Spectroscopy (15L)

Vibrations in simple molecules (H2O, CO2) and their symmetry notation for molecular vibrations

– combined uses of IR and Raman spectroscopy in the structural elucidation of simple molecules

- effect of coordination on ligand vibrations – uses of groups vibrations in the structural

elucidation of metal complexes. Applications of IR and Raman spectroscopy to inorganic

compounds.

References:

1. F.A. Cotton & Wilkinson, Advanced Inorganic Chemistry, John wiley.

2. J.E. Huhey, Inorganic chemistry, Harpes& Row

3. G.Wilkinson, R.D. Gillards& JA McCleverty, Comprehensive Co-ordination Chemistry,

Pergaman.

4. D.Banerjea, Co-ordination Chemistry, Asian Books Pvt. Ltd

5. Lewis &Wilkers, Modern Coordination Chemistry.

6. M. Chand, Atomic Structure & Chemical bond, TMH.

7. M.C. Day &J.Selbin, Theoretical Inorganic Chemistry, Affiliated East West Press Pvt. Ltd.

8. B.R. Puri, L.R. Sharma & K.C. Kalia, Principles of Inorganic Chemistry.

9. B.R. Puri, L.R. Sharma &Pathania, Principles of Physical Chemistry.

10. A. B. P Lever, Inorganic Electronic Spectroscopy, 1986, 2nd Sub. Edition, Elsevier.

12. J. E. Huheey, E. A. Keiter, R. L. Keiter, Inorganic Chemistry Principles of Structures and

Reactivity, 4th edition.

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CH- 103 Physical Chemistry Practical

Objective:

1. To study behavior of electrolyte.

2. To study the dissociation constants and know pH values.

3. To determine the stability constants.

Course Outcome:

After successful completion of the course the students will :

1. Used various instruments likes conductometer, pH meter,

potentiometer, spectrophotometer, polarimeter for various analysis

2. Study kinetics of reaction

3. Determine stability constant , dissociation constant and Hammett constant.

Attempt Any 14 Experiments:

1. Conductometry:

a) Determine the conductance of strong electrolyte (KCl/ NaCl/ AgNO3/HCl) at various

Concentrations and verify the applicability of DHO equation.

b) Determination of degree of hydrolysis and hydrolysis constant of sodium acetate

conductometrically.

c) Study the second order velocity constant of hydrolysis of ethyl acetate by sodium

hydroxide using conductance measurement.

d) Determination of critical micellar concentration (CMC) of sodium lauryl sulphate

fromthe measurement of conductivities at different concentrations.

2. pH -Metry:

a) To determine acidic and basic dissociation constants of an amino acid and hence the iso-

electric point of the acid.

b) To determine the three dissociation constants of polybasic acid such as H3PO4 by pH

measurements.

c) Determination of Hammett constant of a given substituted benzoic acid by pH

measurements.

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8

d) To determine the amount of aspirin in the given tablet. 3. Potentiometry:

a) To determine the stability constant of a complex ion [Ag2(S2O3)]-3potentiometrically.

b) To determine standard free energy change ΔG0 and equilibrium constant for the reaction

Cu + 2Ag+ = Cu+2 + 2Ag Potentiometrically

c) To determine the amount of each halide in a mixture of halides containing KI and

KBr/KCl Potentiometrically.

4. Colorimetry/ Spectrophotometry:

a) Determination of iron in water using a colorimeter.

b) To determine pKa and Ka of given indicator by colorimetry/ spectrophotometry.

c) Record the UV spectrum of Benzene, Pyridine and Pyrimidine in methanol. Compare and

discuss the various transition involved in terms of MO theory.

5. Polarimetry:

a) Polarimetric determination of the specific rotation of camphor in benzene and carbon

tetrachloride.

b) Determine the percentage of two optically active substances (d-glucose and d-tartaric

acid) in a mixture polarimetrically.

6. Chemical kinetics:

a) To investigate the kinetics of iodination of acetone.

b) To determine energy of activation of the hydrolysis of methyl acetate in presence of

hydrochloric acid.

c) To determine the order of the reaction between potassium persulphate and potassium

iodide by fractional change method.

7. Non instrumental:

a) Investigate the adsorption of acetic acid in aqueous solution by using activatedcharcoal

and verify Freundlich’s adsorption isotherm.

b) Determination of partial molar volume of ethanol in dilute aqueous solutions.

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9

c) To study the effect of addition of an electrolyte (KCl /NaCl /NH4Cl / Na2SO4/ K2SO4) on

solubility of an organic acid(benzoic acid or salicylic acid.

Reference:

1. S.W.Rajbhojand Dr. T.K.Chondekar, Systematic Experimental Physical Chemistry, 3rd

edition, Anjali Publication, Aurangabad

2. V.D.Athawale, P.Mathur, Experimental physical Chemistry, New age International Ltd,

New Delhi.

3. J.B.Yadav, Advanced Practical Physical, 19th edition or latest edition, Goel Publishing

House, Meerut.

4. Dr.Pande, Dr.Mrs. Datar, Dr.Mrs. Bhadane, Advanced Practicals in Physical Chemistry,

4th revised edition or latest 13th

Edition,Manali Publication, Pune.

5. P.C.Kamboj, University Practical Chemistry, Vishal Publishing Co. Jalandhar, Panjab.

6. A.M. James and F.F. Prichard, Practical Physical Chemistry, LongmanGroup Ltd.

10

CH-104 Inorganic Chemistry Practical

Objective:

1. To study Analysis of ores 2. To understand the iodometric Method. 3. To know Inorganic Preparations and purity of complexes. 4. To study the determination of concentration of metal in ppm by flame photometer. 5. To study Instrumental methods of quantitative analysis

Course Outcome:

After successful completion of the course the students:

1.Can understand concept of ore extraction.

2. Can apply concept of point potentiometric titration. 3. Can understand the synthesis of inorganic compounds and determination of its purity. 4. Can apply concept to calculate number ppm of metal by flame. 5. Gain the concepts of handling instruments.

1. Analysis of ore (Any One)

a) Pyrolusite ore - Estimation of silica gravimetrically and Manganese volumetrically. b) Haematite - Estimation of copper volumetrically and Iron gravimetrically. c) Chromite ore – Estimation of Iron gravimetrically and chromium volumetrically.

2. To determine the amount of copper present in given solution by iodometric Method

potentiometrically.

3. Inorganic Preparations and purity (Any Four)

a) Bis (ethylene diamine) copper (II) sulphate. b) Tris (acetylacetonato) Iron (III). c) Nitropentammino cobalt (III) chloride. d) 8-hydroxy QuinolineNi(II). e) Potassium trioxalatoChromate(III) f) Tris(acetylacetonato)iron(III)

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11

4. To determine the Li / Na/ K/Ca in given solution flame photometrically, by calibration curve

Method.

5. Analysis of binary mixtures by gravimetric and volumetric methods from the Mixture

Solutions (Any Three) a) Copper- Nickel b) Copper -Magnesium

c) Copper-Zinc d) Iron-Magnesium

e) Silver-Zinc f) Lead-Tin 6. To determine the strength of given mixture of carbonate and bicarbonate in the Given mixture

by pH metric method.

7. Drug Analysis: Determination of iron from given drug sample. 8. To determine the lattice energy of binary salts (NaCl, KCl, CaCl2, MnCl2, CuCl2). (Any two

salts)

9. Chromatography (Any One)

a) Determination of the Rf value of Pb,Cu,Cd ions by using paperchromatographic technique. b) Determination of the Rf value of Fe, Al, Cr ions by using paper chromatographic technique. c) Determination of the Rf value of Ba, Sr, Ca ions by using paper chromatographic technique.

References

1. A. I. Vogel, A text book of Quantitative Inorganic Analysis.

2. W. G. Palmer, Experimental Inorganic Chemistry.

3. W. R. Schoeller and A.R. Powell ,The analysis of minerals and ores of the rarer elements

Griffin and Company Limited.

4. G. Raj Advanced Practical Inorganic Chemistry,Goel Publishing House.

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5. H.N. Patel, S.P. Turakhia, S.S. Kelkar, S.R. Puniyani, Post Graduate Practical Chemistry

(Part – 1), Himalaya Publishing House.

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CH- 105 Laboratory Planning and safety(4 Credits, 60L)

Objectives:

1. Demonstrate safe laboratory skills (including proper handling of materials andchemical

waste) for particular laboratory experiments.

2. To understand importance of safety and health in laboratory.

3. Learn and observe the safety and laboratory rules

4. To study safety management guidelines.

5. To describe hazard information: material safety data sheets (MSDSS), understandand

communicate about laboratory hazards

6. To describe what is GLP and Principles of Good LaboratoryPractice (GLP)

7. To understand types of chemicals / chemical products

8. To study importunes and benefits standard operating procedures (SOPs).

Course Outcome:

After successful completion of the course the students :

1. Can apply laboratory skills such as proper handling of materials and chemical waste for

particular laboratory experiments.

2. Apply safety management guidelines, material safety data sheets (MSDS)

about laboratory hazards.

3. Apply Chemical Management, Storage, Waste and Security.

4. Use standard operating pocedures (SOPs).

5. They apply Personal Protections during laboratory experiments.

6. Can apply Emergency Planning and Process planning

1. Laboratory Planning (15L)

a. Introduction- definition of Laboratory, setting up a Laboratory.

b. Process Planning -Standard operating procedure, special procedure, Ordering materials

c. Emergency Planning- Posting and signs, Emergency action plan, Alarm system

activation, Evacuation procedure, Fire emergencies, spill/release containment and

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cleanup method, Intruders, Vandalism or Theft, Medical emergencies, accident reporting,

safety equipment and supplies, utility outages.

d. Equipment- Safety equipment, Biosafety cabinet, containment/ safety shields, Eyewash

fountains, fire extinguishers, First aid kits, Flammable safety cans, laboratory fume

hoods, Laboratory Refrigeration / Freezers, safety showers, spill kits.

e. Training- Laboratory specific training, Refresher Training, Documentation.

2. Safety Training(15L)

General Lab safety, Emergency Management, Waste Management, Chemical safety, Biosafety,

Radiation safety, Laser safety, Compressed gas Safety, Fume Hood safety, Personal protective

equipment, Chemwatch, Electrical safety, Machine shop safety, Mechatronics lab safety,

Cleanroom Safety and Laboratory Specific training.

3. Personal Protective Equipment (PPE) (5L)

Introduction, Hazard Assessment, Eye and face protection, Head protection, Hand protection,

Protective clothing, Respiratory protection, Hearing protection, Foot protection.

4. Glassware Safety and OSHA laboratory (5L)

Inspecting Glassware before use, Safe handling and storage, Working with glass rods or tubing,

Vacuum and pressure operations, Cleaning and drying glassware, Disposal and spill clean-up.

OSHA Laboratory Practices

5. Chemical Safety (15L)

Safety data sheet, General chemical procedure, Chemical Exposure monitoring, Chemical spills,

Compressed gas safety, Carcinogenic, reproductive and highly toxic chemicals, Chemical

storage guideline

6. Waste and Recycling (5 L )

Biohazardous waste materials, Chemical waste materials, Equipment Disposal, Radiological

waste materials.

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References:

1. IOWA State University.

2. FENS Laboratory , Laboratory safety handbook ,1st

edition, sabanci University ISBN-

9786059178594

3. OSHA Laboratory Practices.

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CH- 106 Organic Chemistry-I (4 Credits, 60L)

Objectives:

1. Understand the features of substitution reaction: SN1, SN

2 reaction, NGP concept,factors

affecting on SN1 and SN

2 reaction.

2. Learn in detail reactions, mechanisms and stereochemistry of different reactions in

organic chemistry.

3. Application of key concepts from organic chemistry including chemical bonding andbasis

of reactivity.

4. Recognize and understand stereochemistry and be able to apply E/Z, D/L configuration,

stereospecific and stereoselective reactions, optical activity in different types of

molecules.

Course Outcome:

After successful completion of the course the students :

1. Understand concept of organic chemistry and different reaction mechanisms.

2. Can use Hammett plot for understanding concept of structure and reactivity.

3. Can draw the mechanisms for Aliphatic and Aromatic Nucleophilic substitutions

reactions. 4. Can give the mechanism of different Electrophilic substitution reactions and understand

their applications. 5. They can apply concept of chirality, chiral centers, Prochiral relationship, homotopic,

enantiotopic and disteriotopic andoptical activity in different types of molecules.

1. Nucleophilic Substitution: (15 L) a)

Aliphatic nucleophilic substitution:

The SN2, SN

1, mixed SN

2and SN

1and SN

imechanism, the neighbouring group

mechanism, neighbouring group participation by π & σ -bonds, Anchimeric assistance.

The SN1 mechanism, Nucleophilic substitutions at an allylic, Aliphatic and a

vinyliccarbon. Reactivity effects of substrate structure, attacking nucleophile, Leaving

group and reaction medium.

b) Aromatic nucleophilicSubstitution :

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SNAr,Benzyne mechanism. Reactivity: Effect of substrate, Leaving group and attacking

nucleophile. The Von Richter, Sommelet-Hauser and smiles rearrangements.

2. Aromatic Electrophilic Substitution: ( 15 L)

Arenium ion mechanism, orientation and reactivity, energy profile diagram, calculation

of partial rate factor, the ortho/ para ratio, Ipso substitution, Orientation in other ring

systems such as Naphthalene, Anthracene, six and five membered heterocycles,

Diazonium coupling, Vilsmeier reaction, Gattermann–Koch reaction etc.

3. Addition reaction (10 L)

Addition to carbon-carbon multiple bonds and carbonheteroatom multiple bonds-

Mechanism and stereochemical aspects of additionreaction involving electrophile.

Structural effects and reactivity:Halogenations, Hydrohalogenation,

Hydration,Hydroxylation, Hydroboration, Epoxidation, Carbene addition,

Hydrogenation, Ozonolysis.

4. Linear free energy relationship ( 10 L)

Hammett plot, Hammett equation, substituent and reaction constants, physical

significance of substituent and reaction constants, substituent constant involving through

conjugation.Use of Hammett plot and equation. Deviations from straight line plot.

Concave upward deviation. Concave downward deviation. Steric effects, Taft equation,

Steric parameters, solvent effects, change of reaction constant.

5. Stereochemistry (10 L)

Concept of Chirality and molecular dissymmetry, Recognition of symmetry elements and

chiral centers, Prochiral relationship, homotopic, enantiotopic and disteriotopic groups

and faces.Recemic modifications and their resolution, R and S nomenclature.

Geometrical isomerism E and Z in C, N, S, P containing compounds,

Prochiralrelationship,stereospecific and stereoselective reactions, optical activity in

biphenyls, spiranes,allenes..

Reference:

1. J. March, J. Wiley, Advanced Organic Chemistry-Reaction Mechanism and structure.

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2. F.A. Carey and R.J. Sundberg , Advanced Organic Chemistry , Plenum.

3. P. Sykes , A Guide Book to Mechanism in Organic Chemistry, Longman.

4. J. Clayden, N. Greeves, S. Warren and P. Wothers , Organic Chemistry,Oxford.

5. R.T. Morrison Boyd ,Organic Chemistry, Prentice-Hall

6. D. Nasipuri, Stereochemistry of organic compound

7. E. L. Eliel, Stereochemistry of Carbon Compounds.

8. P.S. Kalsi, Stereochemistry conformations and mechanism.

9. S.N.Sanyal, Organic Reaction Mechanisms.

10. Sing and Yadav, Advanced organic Chemistry .

11. V.K. Ahluwalia, R. Kumar. Organic Reaction Mechnism.

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SEMISTER II

CH- 201 Physical Chemistry-II (4 Credits, 60L)

Objective:

1. To study theories and basic concepts of Chemical kinetics and enzyme Catalysis reaction.

2. To study the nuclear chemistry and spectroscopy.

Course Outcome:

After successful completion of the course the students :

1) Can understand rate, rate laws and rate law of chain reaction, explosion,

kinetic polymerization and reaction dynamics.

2) Can study nuclear reaction, basic concept of decay growth relationship of parent

and daughter.

3) Can study application of radioactivity and neutron activation analysis

4) Can understand the energy of diatomic molecules, vibration, rotation and influences

of rotation spectra.

1. Chemical Kinetics (20 L)

a) Rate of reaction- rate, rate law, rate constant, reaction order, Accounting for the rate

laws:reactions approaching equilibrium, consecutive elementaryreactions, rate determining

steps,\ steady state approximation, pre-equilibria, Michaelis-Menten mechanism, Lindemann-

Hinshelwood mechanism, chain reactions, rate laws ofchain reactions, explosions.

b) Polymerization kinetics: chain and stepwise polymerization andtheir rate laws, chain length

andaverage number of units in each chain.

c) Molecular reaction dynamics: Diffusion controlled reactions, activated complextheory,

Eyring equation, thermodynamic aspects, Hammett and Taft equation.Fast reactions: Flash

photolysis, flow methods, relaxation methods and magnetic resonancemethods.

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2. Nuclear Chemistry (10L)

Parent-daughter decay-growth relationships:daughter nucleus stable, general expression

foractivity of daughter, parent shorter and longer lived than daughter, parent and daughter

ofnearlythe same half life, secular and transient equilibrium. Problems.Applications of

radioactivity:Szilard - Chalmer's reaction, Isotope dilution. Elements of radiation chemistry: primary effects of interaction of radiation with matter, LET ,

Bremsstrahlung. Interaction of gamma radiation with matter: photoelectric effect, Compton

scattering and pair production, units of measuring radiation Neutron activation analysis-

Principle,applicationand problems.

3.Spectroscopy (20L)

a) Infra -red spectroscopy(12 L)

The energy of diatomic molecules, the simple harmonic oscillator ,the

anharmonicoscillator,diatomic vibrating rotator, vibration-rotation spectrum of diatomic,

molecule applying Born-Oppenheimer approximation,breakdown of Born-oppenheimer

approximation, vibrations of polyatomic molecules,fundamental vibrations and their

symmetry,the possibility of overtone and combination bands ,the influence of rotation on the

spectra,problems.

b)Raman Spectroscopy (8L)

Classical and quantum theories of Raman effect, Pure rotational Raman spectra,linearmolecules,

symmetric top molecules, Raman activity of vibrations,rule of Mutual exclusion , vibrational

Raman spectra,rotational fine structure.

c)Electronic spectroscopy of molecules Mossbauer spectroscopy (10L)

The Born-Oppenheimerapproximation,Vibrational coarse structure,Intensity of vibrational

Electronic spectra,( Franck-Condon principle),dissociationenergy and dissociation products, The

Fortrat diagram predissociation.

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Mossbauer spectroscopy: Principles of mossbauerspectroscopy,Applications of mossbauer

spectroscopy.

Reference:

1. P. W. Atkins, J. D. Paula, Physical Chemistry, 5th or 6th edition, Oxford University Press 2. K. J. Laidler, J. H. Meiser , Physical Chemistry, 2ndEdition (CBS Publications) 3. L.R. Sharma, B. R. Puri and M. S. Pathaniya, Principles of Physical Chemistry- 41st

Millennium edition 4. C. N. Banwell and McCash, Fundamentals of Molecular Spectroscopy- 4th edition Tata Mac-

Graw Hill 5. S. H. MaronandC.F.Prutton , Principles of Physical Chemistry, 4th edition, Oxford and IBH

Publishing Co. 6. H. J. Arnikar, Essentials of Nuclear Chemistry- 4th edition.

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CH- 202 Inorganic chemistry- II (4 Credits, 60L)

Objective:

1. To study electronic spectra of an atom. 2. To understand the Group theory and its applications.

3. To know General introduction of Bioinorganic chemistry .

4. To study the Organometallic Chemistry of transition elements. 5. To study Cluster compounds.

Course Outcome:

After successful completion of the course the students :

1.Can understand structure of an atom.

2. Can apply concept of point group and geometry of molecules. 3. Can understand the importance of metals in living system.. 4. can apply concept to calculate number of electrons in complexes and stability of complexes. 5. Gain the concepts of STYX number and geometry of cluster compounds.

1. Spectra (15L)

Energy levels in an atom, coupling of orbital angular momenta, coupling of spin angular

momenta, spin orbit coupling. Determining the ground state terms – Hund’s rule, Hole

formulation, Derivation of the terms for a P2 & P3 configuration, calculation of the number of

microstates, Electronic spectra of transition metal complexes – Laporte ‘orbital’ selection

rule,spin selection rule, splitting of electronic energy levels and spectroscopic states. Spectra of

d1& d9 ions, d2 & d8 ions

2. Group theory and its applications (10L)

Symmetry elements and operations, Symmetry planes, reflections, inversion centre, proper /

improper axes of rotation, equivalent symmetry elements and atoms, symmetry elements and

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optical isomerism, Classification of point groups and procedure to determine the point group,

with at least one example of each point group.

3. Bioinorganic chemistry (10L)

Role of metal ions in biological processes, structure and properties of metalloproteins in electron

transport processes, cytochromes, ferrodoxins and iornsulphur proteins, ion transport across

membranes, Biological nitrogen fixation, PSI, PS – II, Oxygen uptake proteins.

4. Organometallic Chemistry of transition elements (15L)

Ligand hapticity, electron count for different types of organometallic compounds, 18 and 16

electron rule exceptions, synthesis, structure and bonding, organometallic reagents in organic

synthesis and in homogeneous catalytic reactions (Hydrogenation, hydroformylation,

isomerisation and polymerisation), pi metal complexes, activation of small molecules by

coordination.

5. Cluster compounds (10L)

Boron hydrides: Classification, nomenclature, structure, bonding and topology of boranes, 4-

digit coding (s, t, y, x) numbers for higher boranes and their utilities. Chemistry of diboranes:

Study of Metalloboranes, Carboranes and Metallocarboranes with reference to preparations and

structures.

References:

1. P.Atkins, Inorganic Chemistry- 4th Edition, Oxford University Press.

2. F.A. Cotton.,Chemical Applications of Group Theory.

3. B.R. Puri, L.R. Sharma & K.C. Kalia, Principles of Inorganic Chemistry.

4. P.K. Bhattacharya, Group Theory and its Chemical applications, Himalaya Publishing House.

5. K. Arora, Concept and Applications of Group Theory, Anmol Publication Pvt.Ltd., New

Delhi

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6. J. E. Huheey, E.A. Keiter, R. L. Keiter, O. K. Medhi , Inorganic Chemistry.

7. J. D. Lee , Concise Inorganic Chemistry- 5th edition

8. Williams, An Introduction to Bioinorganic Chemistry.

9. G. L. Eichhron, Inorganic Biochemistry- Vol I and II, Elesevier

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CH- 203 Organic Chemistry Practical

Objectives:

1. Understanding the organic synthesis by single stage and double stage preparations

derivatives of organic compounds.

2. Studying experimental techniques such as steam distillation and column chromatography

for the purification and analysis of given organic compounds.

3. To draw the structure, elemental analysis, IUPAC name and predict the NMR Signals of

simple aliphatic and aromatic and heterocyclic compounds and basic reaction with their

mechanism. Course Outcome:

After successful completion of the course the students will :

1) Able to draw structure, reaction mechanism and NMR spectra by using Chemistry software’s.

2) Able to synthesize organic compounds by single and double stage preparation method.

3) Carry out various techniques for the purification and analysis of given

organic compounds. 4) Apply the green Chemistry principals for preparations of organic compounds.

1. Use of Chemistry software’s like, ISI draw, Chem Draw, Chem Sketch

a) Draw the structure of simple aliphatic and aromatic compounds, heterocyclic compounds

with different substituent.

b) IUPAC name and predict the NMR Signals.

c) Sketch Design reaction mechanism scheme of any two addition and two substitution

reactions.

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d) Literature Search and references 2. Dervatives (Any Three)

a) Phenyl hydrazone derivative of Aldehyde/ketone.

b) Anilide derivative of carboxylic acid

c) Imine derivative of aldehyde or ketones.

d) Oxime derivative of aldehyde or ketones.

e) Aryloxy derivative of carboxlic acid

3. Green Synthesis (Any Three)

a) Bromination of acetanilide using Cerric ammonium nitrate.

b) Preparation of Benzilic Acid using NaOH /KOH under Solvent-free Conditions.

c) Synthesis of acetanilide from aniline by using ZnO/AcOH

d) Synthesis of Dibenzalpropanone from Benzaldehyde and Acetone(Aldol Condensation).

e) Synthesis of Dihydropyrimidinone from Ethyl acetoacatate,Benzaldehyde and Urea. 4. Use of Reagents (Any Three)

a) Resorcinol to 7-hydroxy, 4-methyl coumarin (H2SO4)

b) Camphor to Borneol (NaBH4)

c) P- nitrotoluene to p- nitrobenzoic acid. (Sodium Dichromate)

d) Cyclohexanone to Adipic acid (HNO3)

5. Two stage Preparations: (Any Two)

a) Phthalic acid - phthalic anhydride - phthalimide.

b) Chlorobenzene- 2,4- dinitrochloro benzene - 2,4- dinitrophenol.

c) Acetophenone -Oxime - Acetanilide.

d) Nitrobenzene - m- Dinitrobenzene - m- Niroaniline.

6. Purification Techniques (Demonstrations) (Any One)

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a) Solvent extraction using soxhlet extractor.b) Steam distillation. C) Column

Chromatography.

References:

1. A.I. Vogel’s., Practical Organic Chemistry. 2. Monograph on Green Chemistry Laboratory Experiments. 3. A. K. Ahluwalia and RenuAgrawal 4. Comprehensive practical Organic Chemistry.

CH- 204 Analytical Chemistry Practical

Objectives:

1. To determine the degree of dissociation, empirical formula, stability by various methods. 2. To determine pH, pKa,concentrations of given compounds by instrumental methods. 3. Estimate the heavy metals from water samples.

4. Uses softwares regarding to analytical chemistry.

Course Outcome:

After successful completion of the course the students will :

1. They prepare solutions of different concentrations based on volume and mass unit.

2. They used Data Handing and Spreadsheets in Analytical Chemistry by using softwares.

3. They acquire knowledge of modern separation methods and Hyphenated techniques.

4. They used instruments like HPLC, AAS and flame photometer for analysis.

Attempt any 12 experiment from following:

1) Acid-base titration in non-aqueous media by pH-metry (benzoic acid inethanol / NaOH).

2) Determination pKa of weak acid by pH-metry.

3) Determination of degree of dissociation of weak electrolyte and to study the

4) deviation from ideal behaviour that occurs with a strong electrolyte.

5) Verification of Beer’s law for KMnO4and Cu+2

ammonia complex solution.

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6) Determination of empirical formula for the formation of ferric salicylate complex by

Job’s method.

7) Determination of stability constant for the formation of complex between Fe+3 ions and

5-sulphosalicylic acid

8) Estimation of Na+ / K+ / Ca2+ by Flame photometry

9) Determination of amount of Cr (III) and Fe (III) individually in a mixture of two by

Complexometric titration

10) Solvent Extraction: (1) Fe (III) & Mg (II) and (2) Fe (III) & Ni (II)

11) Water analysis: Hardness, alkalinity, salinity, acidity

12) Anion exchanger chromatography: (1) Ni (II) & Zn (II) and (2) Co(II) & Ni(II)

13) Determination of Iodine value and Acid value of given oil sample

14) Column chromatography: separation of a mixture of ortho and para-nitroanilines.

15) Assay of Chlorambutol using precipitation titration.

16) Extraction and separation ofcurcumine/beetroot/ ginger by soxhlet apparatus.

17) Determination of Boron/N/P/ K from Soil sample.

18) Analysis of Heavy metals from water samples by AAS.

19) Determination of phosphoric acid in cola beverages by pH titration.

20) Data analysis by Mini TAB Software.

References:

1. Vogel , Inorganic quantitative analysis, sixth edition.

2. Pharmacopeia of India.

3. Sadashivam and Manichem, Biochemical methods, , New age international publication

4. Elias , General Chemistry experiments, Universities Press

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CH-205 Analysis and monitoring of Environmental Pollution (4 Credits, 60L)

Objective:

1. To study the Air and Noise Monitoring.

2. To impart basic knowledge about water and soil pollution and their analysis.

Course Outcome:

After successful completion of the course the students :

1) Monitor air pollution by various methods.

2) Use various techniques of analysis of soil and water.

1. Air Pollution (20L)

Air quality monitoring: Micrometeorology; Objectives, Siting criteria for AQMS, Ambient and

source emission monitoring, NAAQS, EPA-USA AQS, Monitoring frequency, Reporting, AQ

monitoring for existing industry and for new industry, Self test Monitoring of particulate

pollutants: Dustfall, Calibration ofHVS, monitoring ofSPM, RPM, Lead, aeroallergens and aero

microbes Monitoring of gaseous pollutants: Collection of gaseous pollutants, Monitoring of NO

x' S02' Sulphation rate, Oxidants (NBKI ), CO (NDIR), Vehicle exhaust monitoring, Selftest.

Stack monitoring: Objectives, Measurement of emission, Sampling, Steps in stack monitoring,

Calculation, Self test, Chemicals Apparatus/instruments required for soil analysis laboratory.

2. Noise Monitoring (10L)

Objectives, dB, SPL, Sources and effects of noise, Noise survey, Noise measurement instrument-

SPL meter - Types and features and Control facilities, Weighting network, Octave band analyser,

Noise dosimeter, Audiometer, Noise rating, Lcq' Ldn, L10 L~O' L90, NEI, TNI, NIl, NNJ; Noise mapping; Octave band analysis, Audiometric survey, Standards-CPCB, OSHA and ISO,

Community noise standards- WHO, CPCB, IS, ILO, air blast, Self test on noise monitoring.

3. Soil Analysis (20L)

Sampling techniques: Objectives, Steps in sampling, On-site tests and description, Sample

preparation Analysis of physical parameters: Introduction, Coarse fractions, Texture, Bulk

density and pore space, Field moisture, WHC, Wilting point, Infiltration rate, Self test Analysis

of Chemical parameters: pH, Lime requirement, EC, Organic carbon, Organic matter, Total

nitrogen, Av. N, Av. P (Bray's and Olsen's), Total P, P-fixing characteristics of soil, Exch. K,

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Exch. Na and SAR, CEC, Av. S, Exch. Ca and Mg, Chloride, Monitoring of Pb, Fe, Cu, Mn, Zn,

Ni and Cr, Cd, DTPA fractions, Hg Soil.

4. Water Analysis (10L)

Introduction, Major water pollutant, water pollution in various water bodies, status of coastal and

Estuarine pollution in Indian, Water pollution and health, Control of water pollution, River water

pollution in India, Lake water pollution.

References:

1. S. K. Maiti , Handbook of Methods in Environmental Studies, ABD Publishers.

2. S.M. Shafi, Environmental Pollution, Atlantic Publisher, New Delhi.

3. V.K. Ahulwalia, Environmental Pollution and Health. TERI Press , New Delhi.

31

CH-206 Organic Chemistry- II (4 Credits, 60L)

Objectives :

1. Study Nuclear Magnetic Resonance Spectroscopy to determine the structure of organic

compounds.

2. Study the mechanism of several name reactions such as Shapiro, Perkin, Benzoin

,Rosenmund reaction , Reformatsky,Rosenmund reaction.

3. Students will learn the selectivity , stereochemistry and important applications of several

oxidizing and reducing agents.

4. Introducing Carbon magnetic Resonance and mass spectrometry

5. In organic spectroscopy, structure elucidation will be learnt using techniques such as UV,

IR, NMR etc. Emphasis is on problem solving in organic spectroscopy. Course Outcome:

After successful completion of the course the students :

1. Can apply knowledge of oxidizing reagent in different organic reaction conversions.

2. Use strong, mild reducing agents for various organic conversions.

3. Can apply variety of rearrangements in organic transformations.

4. Explore basic concept and principle of CMR and MASS spectroscopy.

5. Solve the problems based on UV, IR and PMR Spectroscopy.

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1. Spectroscopy (15 L)

PMR: a) Fundamentals of PMR, chemical shift, factors affecting chemical shift, anisotropic

effect, spin-spin coupling, coupling constant, applications to simple structural problems

integrationcoupling (1st

order analysis)

b) Introduction to CMR and mass spectrometry

c) Problems on UV, IR and PMR

2. Molecular rearrangement and reaction intermediate (15L)

Structure, generation and stability of carbenes, nitrenes, carbocations and carbanions

intermediates. Rearrangement reactions viz. Beckmann, Curtius, Hofmann, Lossen, Favorskii,

Baeyer-Villiger, Wolff, Claisen, Pummerer, Wagner-Meerwin, Stevens, Dienone-Phenol,

Sommelet-Hauser, Benzilic acid, Benzidine, Cope, Fries, Neber and Schmidt reaction.

3. Name Reaction (15 L)

Bayer- Villiger Oxidation, reformatsky, Robinson annulation, Stork enamine, Sharpless

asymmetric epoxidation, Ene, Barton, Hell- Volhard- Zelinsky reaction, Shapiro reaction,

Chichibabin reaction, VislmairHacck reaction, Ulman reaction, Rosenmund reaction, Darzen

reaction, Knovenagel reaction, Biginelli reaction.

4. Synthetic Reagents ( 15L)

a) Oxidation reactions:

CrO3, PDC, PCC (Corey’s reagent), KMnO4, MnO2, Swern oxidation, SeO2, Pb(OAc)4, Pd-C,

OSO4, m-CPBA, O3, NaIO4, HIO4, chloranil, DDQ, Oppenauer oxidation

b) Reduction reactions:

LiAlH4, NaBH4, NaCNBH3, MPV reduction, Na/liquor NH3, H2/Pd-C, Willkinsons catalyst,

DIBALH and Wolff Kishner reduction, Zn-Hg/H2O/HCL, Bu3SnH.

References:

1. V. K. Ahluwalia , Organic reaction mechanism, 3rd Ed.

2. J. Clayden, N. Greeves, S. Warren and P. Wothers , Organic Chemistry,Oxford.

3. H.O. House , Modern Synthetic reactions.

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4. S.N. Sanyal, Reaction Rearrangement and Reagrnts.

5. P. Sykes.Guide book to Reaction Mechanism.

6. D.Pavia, G.M. Lampman, G.S. Kriz, Introduction to spectroscopy –3rd Edition

7. .H. William & I Flemming , Spectroscopic methods in organic molecules, D McGraw Hill

8. E.S. Gould, Mechanism and Structure in Organic Chemistry.