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Study guide for Chemistry 2013/2014 Published by the Study Board of Chemistry at Roskilde University Editing and layout: Pia Sander Alexander Svanbergsson Søren Hvidt Jens Josephsen Printed by: RUC’s press Edition: August 2013 Address: Roskilde University Department of Science, Systems and Models Postboks 260 Universitetsvej 1 DK - 4000 Roskilde Telephone: 46 74 24 22 Fax / E-mail: 46 74 30 11/ psander@ruc.dk Homepage: http://www.ruc.dk/kemi/ © 2013, KEMI SN, RUC.

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Table of contents

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PREFACE THE DEPARTMENT The Study Board of chemistry Members of the Study Board: INTRODUCTION Semester start-up at Chemistry September 2012 THE STUDY OF CHEMISTRY AT ROSKILDE UNIVERSITY Contemporary study plan The Basic Science studies (nab in Danish or nib in English) Problems regarding the bachelor degree Supplementary rules (approved by the Study Board, August 2012) CHEMISTRY COURSES Descriptions of courses Bachelor courses: Master courses:

Mandatory Elective

REGULATION OF ASSESSMENTS OF COURSES SIGNING UP FOR COURSES AND EXAMINATIONS EXAMINATION DATES*: Winter exam 2012/13 Chemistry: Summer exam 2013 Chemistry: Re-examination KARAKTERGIVNING Grading PROJECTS Oral project exam Project market THE MASTER THESIS AND THE MASTER PROJECT (30 OR 60 ETS). SPECIALER OG KANDIDATPROJEKTER (30 OG 60 ECTS) PROJECTS COMPLETED IN 2011/12 Bachelor level-projects Master thesis APPLICATIONS FOR CREDIT TRANSFER STUDIEOPHOLD I UDLANDET (ONLY IN DANISH) CHEMISTRY STAFF Technical employees Ph.D. students and Post-doctoral fellows Administrative employees in the Department of Science, Systems and Models in 18.1+2 INFORMATION FOR STUDENTS AT THE DEPARTMENT OF SCIENCE, SYSTEMS AND MODELS CONCERNING SAFETY.

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Preface Chemistry is one of the science disciplines and it deals with matter, its composition and properties and how one compound or material is converted into another… Almost everything in our surroundings in the material world has a chemical perspective and chemical knowledge has great impact on how we comprehend nature. Indeed, Chemistry has had an immense influence upon the development and use of materials and chemicals with specific properties, and the mastering of Chemistry is indispensable when it comes to the preservation of the environment. Chemistry, as one of the old science disciplines, is rich in tradition. Chemistry has its roots in prehistoric technology and ancient speculations, but for centuries Chemistry was primarily an experimental endeavour. Results were not easily predictable, though experience could be very helpful. Gradually useful chemical concepts evolved and parallel with developments in Physics a firm fundament of chemical theories was formed for our understanding of chemical phenomena. Also on the experimental side, Chemistry has developed an impressive number of clever and accurate methods to explore the nature and properties of matter. Today the chemists working area is more complex than ever and Chemistry is a challenging and rewarding subject. The study of Chemistry thus demands a determined effort. At Roskilde University the programme is composed of a number of projects and courses. The course programme gives the basic and broad chemical knowledge, skills and experience, while the projects give the opportunity to work in depth and develop other capabilities in specialised areas of Chemistry. The choice of subject of study in the projects is a way to effectively obtain the individual specialisation. There is a tradition, that the experimental dimension of the projects is important. Chemistry at Roskilde University is combined with another subject on a fifty-fifty basis and the chemical experience will often be of great importance in the study of the other subject and vice versa. The most obvious subjects are combinations of Chemistry with either Molecular Biology, Environmental Biology or Physics, but also Medicinal Biology and Mathematics are frequently chosen by students. Many other interesting and non-conventional combinations involve e.g. Computer Science, History, and International Development studies, just to mention a few. A master degree in Chemistry and another subject most probably points towards a job in research and development or in teaching. From the latest survey (Spring 2006) of the 36 candidates who in 2002 and 2003 graduated with a Master degree with Chemistry from Roskilde University, all except one (who was indisposed) had a job. Almost half of these had a research position. On behalf of the experienced and engaged teaching staff I would like to welcome you to the Chemistry studies at Roskilde University. Jens Josephsen (Head of studies in Chemistry)

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The Department

Department of Science, Systems and Models was established 1st of September 2006 where the former Departments for Mathematics/Physics and Biology/Chemistry, respectively, were merged. The background for the merger was the ambition of crossing traditional borders of disciplines in order to create new, untraditional research areas and products.

The department offers the following study programmes: Chemistry General Biology Mathematics Medical Biology Molecular Biology Physics Head of Department Stine Korreman Building 18.1 Phone no.: 4674-3156, E-mail: korreman@ruc.dk Head of Secretariat Margit Christiansen Building 18.2, Phone no.: 4674-2050, E-mail: macr@ruc.dk Secretariat: Secretary, Department of Science Systems and Models Louise Damgaard Jensen Building 18.1 Phone no.: 4674 -2744, E-mail: lodaje@ruc.dk

The Study Board of chemistry

The Study Board is responsible for the curriculum and its administration, for quality assurance and development of programmes with chemistry. As a student you may participate in the development by becoming a student member of the committee or by participating in the discussions and debate about the teaching and the administration of curriculum. The committee can be reached by contacting the secretary of the committee in building 18.1 or through one of the committee members.

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Members of the Study Board: Staff representatives: Jens Josephsen, chairman, head of studies (phjens@ruc.dk) Søren Hvidt, staff, (hvidt@ruc.dk) Student representatives: Camilla Maria Højer Knudsen, student representative (cmhk@ruc.dk) Alexander Svanbergsson, student representative (svanberg@ruc.dk) Secretary: Pia Sander, 18.1, phone: 4674-2422 (psander@ruc.dk)

Introduction

This study guide contains a variety of information about the chemistry curriculum at RUC. It also contains some information about your daily life as a chemistry student in the Department of Science, Systems and Models. Among other things you will find the semester plan for the Fall 2013 and Spring 2014 semesters, and information about available courses and necessary textbooks. The bachelor and master programmes with chemistry at RUC are described, just as examples of previous projects are given. In the back you will find a list of the personnel in chemistry. If you need more information or have corrections and additions to this book or miss important information, please contact the secretary of the Study Board of Chemistry, Pia Sander in building 18.1.

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Semester start-up at Chemistry September 2013

Time Monday 2. Sep.

Tuesday 3. Sep.

Wednesday 4. Sep.

Thursday 5. Sep.

Friday 6. Sep.

9.15 ______ 11.00

10.00 – Welcome and breakfast in 15.1 Introduction to Chemistry and Biology.

11.15-12.15 Bachelor study introduction in 15.0

Instrumental Analytical Chemistry Organisk Kemi

12.00

Lunch

Lunch

Lunch

Lunch

13.00 ______ 14.00 ______ 15.00

13.00-16.00 Safety course for Biology and Chemistry in 15.0 Mandatory for 3. year students and new students!

From 5 pm All Biology, Chemistry, Matemathics and Physics students and staff cook and eat together in 27.1

13-16 Project market in ”Lærerværel-set”, 17.2

Instrumental Analytical Chemistry

From 16.00 Maybe “Chemobar” Party in building 16.2

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Time Monday 9. Sep.

Tuesday 10. Sep.

Wednesday 11. Sep.

Thursday 12. Sep.

Friday 13. Sep

9.00

Organisk Kemi 11-12 Project Market in Lærer- værelset, 17.2

Instrumental Analytical Chemistry Organisk Kemi

12.00

Lunch

12.15-13.15 Project Market in 18.1

13.00 _______ 15.00

Instrumental Analytical Chemistry

Instrumental Analytical Chemistry

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The study of Chemistry at Roskilde University

This guide is valid for bachelor students enrolled earlier than August 2012. From fall 2012 new regulations are valid for the bachelor’s programme, and this will be described in the “Handbook for Chemistry 2014/15”. Chemistry is a subject in the general combination structure at RUC. The Master degree at RUC in two subjects builds upon a three-year broad bachelor study programme with chemistry as one of the two specialized subjects. For students enrolled 2011 or earlier A Bachelor programme with Chemistry consists of: 1. A basic study, usually Basic Studies in Natural Sciences 2. The bachelor module of Chemistry 3. The bachelor module of another subject in the combination structure A master programme with Chemistry consists of: 1. A bachelor degree with Chemistry 2. The two master's modules in the combination subject 3. The two master's modules in Chemistry The programme structure is represented by this box diagram: Chemistry Other subject 2. Master's module

1. Master's module

Master's studies

(Kandidat studier)

Bachelor Module Bachelor studies

Basic Studies:

4 Basic modules

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Contemporary study plan We highly recommend that you in the beginning of studying your specialized degrees make a contemporary plan of how you are going to complete your studies. You have to think especially about the subjects you choose and in which order it is best combined with your second subject. Of course this plan can be changed, in order to fit your actual study situation.

The Basic Science studies (nab in Danish or nib in English) During these first two years of the bachelor study the student chooses 8 courses and normally completes two courses per semester. A course usually consists of 70-80 hours of class-teaching. Furthermore the student completes four projects, of which at least one must include experimental work. The experimental work must be more than just “making chemical analysis” to be a good introduction to Chemistry. Upon completion of the basic science studies the student can be admitted to the bachelor year. In order to have an effective study start in Chemistry, i.e. without substantial extra reading, the student must have achieved the so-called normal-qualifications for Chemistry. They imply that the student during the basic studies has completed the courses “Calculus of several Variables”, “Mekanik og atomfysik” and mathematics, physics and chemistry equivalent to at least high school A-levels. It is furthermore recommended that students have completed the course “Inorganic Chemistry”. If one does not have an A-level in Chemistry from high school one can complete “Chemical Reaction” and “Organic Chemistry” to achieve such qualifications. The standards of evaluation in the 3 chemistry courses are satisfactory completion of individual papers (mandatory papers and written examination) including mandatory laboratory reports (approved reports).

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The Chemistry programme Study programme according to 2007 regulations http://www.ruc.dk/ruc/internesider/regelsamling/studieordninger/kemi/ Applies to students enrolled after August 31, 2006 Module Project Courses

Bachelor Project 15 ECTS Instrumental Analytical Chemistry and Applied Spectroscopy (3 ECTS each) Physical Chemistry (9 ECTS)

1.Master's Organic Chemistry and Inorganic Chemistry (7.5 ECTS each) Synthesis (3 ECTS) Elective courses (12 ECTS)

2.Master's Project A and Project B (15 ECTS each) or combined project (master thesis) 30 ECTS

The most obvious combinations of chemistry are with biology or physics; the courses here are for the most part on other days than chemistry, so it is possible to follow courses in the same semester. The most frequent combinations are with molecular biology, medical biology, environmental biology and physics.

Problems regarding the bachelor degree The chemistry advanced studies consist of two parts: the bachelor education followed by the Master degree study. This means that one has to complete the bachelor studies before starting on the 1st candidate module. This distinction between the two parts is very inconvenient for many students. So it is a good idea to plan for a completed bachelor degree including both subjects before aiming at the master degree study.

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Supplementary rules (approved by the Study Board, August 2013) Course plan: see page 12. Changes to this plan may occur only if absolutely necessary. Course assessments: see the course descriptions from page 14 Cancellation of courses: The Study Board for Chemistry can decide to cancel an elective course with only five or less participants. Changes in assessments: Internal written tests can be changed to oral tests when only a few students have signed up. Written re-examinations can be changed to oral examinations when only a few students have signed up. The Head of Studies decides. Course evaluations. At the end of each course the responsible teacher will initiate an evaluation of the course set up and teaching. The responsible teacher may be asked to make up a course evaluation report including student response to be handed in to the Study Board for Chemistry. Project group formation around preliminary titles of the coming projects is organised through the "project markets" at the beginning of each semester, see page 28. Titles and allocation of supervisors have to be approved by the Head of Studies. Size of project groups. A group normally has 4-5 members. Small groups will not be recommended at bachelor level or for a "short" master level project (15 ECTS), since only a limited number of supervision hours are available. The Head of Studies approves. Master Project (Thesis or ordinary project) A procedure for the allocation of supervisor, for the deciding and acceptance of the title and topic of the project work and for the time limits for the work has been devised. See page 29 + 30 Abstracts When you hand in your project reports, you also have to hand in a separate sheet with the title of the project, its authors and the abstract. You may do this electronically. This sheet will be signed by the Study Board upon request and may serve as a diploma supplement.

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Chemistry courses

You are able to direct your chemistry studies towards fields in which you are interested. Physical Chemistry, Instrumental Analysis and Applied Spectroscopy are mandatory in the Bachelor programme, while Organic Chemistry, Inorganic Chemistry and Synthesis are mandatory at the Master level. At the Master level you have to earn 12 more ECTS points (no more, no less!) with elective courses. The course plan for the next two years is given below: Courses ECTS Tentative§

plan 14/15

Bachelor Mandatory Instrumental Analysis (AKA) 3 Fall 13 new course

Mandatory Applied spectroscopy (AKB) 3 Fall 13 new course

Mandatory Physical Chemistry 9 Spring 14

new course

Candidate Mandatory Organic Chemistry 7,5 Fall 13 Fall 14

Mandatory Inorganic Chemistry 7,5 Spring 14

Spring 15

Mandatory Synthesis 3 Fall 13 Fall 14

Elective Computational Chemistry 3 Fall 14

Elective Bioorganic Chemistry 3 Spring 15

Elective Microcalorimetry 1,5 Spring 15

Elective Kemiske Undervisningsforsøg*

4,5 Spring 15

Elective Biophysical Chemistry 3 Fall 13

Elective Bioinorganic Chemistry 3 Fall 13

Elective 2 D NMR 3 Spring 14

Elective LC-MS 1,5 Spring 14

* In Danish only § From 2014/15 the mandatory courses in the Bachelor programme will change according to the 2012 reform. In subsequent years all courses will be reformulated in a 5 ECTS regime. More information about the courses is found in later chapters.

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Notice that not all courses are offered each semester, which makes it important for you to plan your studies. Chemistry students aiming at teaching in upper secondary school have to pass the course Experimental School Chemistry (Kemiske Undervisningsforsøg). Turn to the description of courses to see how to become able to teach chemistry in upper secondary school. NB! Most courses will be taught in English since international students are studying chemistry. Projects, reports as well as exams can be submitted in Danish. At least six students have to attend a course in order for it to be established. The plan for the fall term is given on the next page: Changes in the course calendar may occur later

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Week - X Monday Tuesday Wednesday Thursday Friday Dates 36 Morning Introduction AKA OK 2.9 – 6.9 Afternoon Bach-Safety P-market AKA 37 Morning OK AKA OK 9.9 - 13.9 Afternoon AKA AKA 38 Morning OK AKA OK 16.9 - 20.9 Afternoon AKA AKA 39 Morning OK AKA OK 23.9 - 27.9 Afternoon AKA AKA BPC 40 Morning OK AKA OK 30.9 – 4.10 Afternoon AKA BPC 41 Morning OK OK 7.10 – 11.10 Afternoon AKA BPC 42 Morning OK OK 14.10 -18.10 Afternoon BPC 43 Morning OK OK 21.10 -25.10 Afternoon OKØ BPC OKØ 44 Morning OK OK 28.10 -1.11 Afternoon OKØ BPC SY 45 Morning OK OK 4.11 -8.11 Afternoon SY BPC SY 46 Morning OK OK 11.11 -15.11 Afternoon SY BPC SY 47 Morning OK OK 18.11 -22.11 Afternoon SY BPC SY 48 Morning OK OK 25.11-29.11 Afternoon SY BPC SY 49 Morning OK OK 2.12- 6.12 Afternoon BPC 50 Morning OK 9.12 -13.12 Afternoon BPC Course title Pool Module AKA Analytical Chemistry A Mandatory Bach. programme AKB Analytical Chemistry B Replaced by Analyt. Spectroscopy Mandatory Bach. programme OK 3 Organic Chemistry OBS:10-13 Mandatory Master programme SY Synthesis Mandatory Master programme BPC Biophysical Chemistry (10 sessions + test) Elective Master programme BIC (to be scheduled) Bioinorganic chemistry Elective Master programme

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Descriptions of courses

Safety courses At the beginning of the Bachelor module in chemistry there will be a safety course, dealing with rules for laboratory work, waste disposal and procedures regarding accidents. The safety course consists of two parts. The first short one is for all students of chemistry and/or one of the biology subjects at the department. It takes place on Monday the 2. September 2013 from 13.00. The more advanced part is integrated into Instrumental Analytical Chemistry (Analytical Chemistry A). For this course you need to get the "Laboratory Handbook" and read it before the course. Attendance at the safety course is mandatory.

Bachelor courses: Instrumental Analytical Chemistry (AKA) (3 ECTS) Aim: After completing the course successfully, the student is able to analyse and discuss analytical data which are obtained by using simple and more advanced equipment and procedures for chemical analysis on complex samples. Contents: Analytical chemistry is treated from an experimental point of view and includes safety issues, different analytical procedures and the handling and reliability of data. The laboratory part includes techniques such as spectrophotometry, electrochemical methods, chromatographic methods and flow injection. Format: Lectures with exercises and laboratory assignments. Volume: 13 sessions of three-four hours Prerequisites: General Chemistry or equivalent and Organic or Inorganic Chemistry Teaching material: "Lab course in analytical chemistry" RUC, 2007. Textbook: Daniel C. Harris "Quantitative Chemical Analysis" (7. ed.) W.H. Freeman and company (New York) ISBN: 978-0-7167-7041-1 Assessment: With the student having participated actively in the safety course and the practical assignments in the laboratory, the student is assessed on the basis of his or her written reports on eight laboratory assignments and graded pass/ non-pass. Pass is given for the reports demonstrating that the student at least to a limited but sufficient extent is able to deal with analytical equipment and techniques and to treat data according to acceptable standards. Applied spectroscopy (AKB) (3 ECTS) Aim: After completion of the course the student is able to identify moderately complex organic compounds based on Nuclear Magnetic Resonance (NMR), Infra- red (IR) and Mass spectrometry.

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Content: The course concentrates on identification of organic compounds using spectroscopic methods. The main focus is on 1D NMR. The nuclei investigated are 1H, 13C and to some extent 15N, but nuclei such as 31P and 19F are also briefly treated. In addition to NMR, interpretation of EI (electron impact) mass spectra is discussed in detail and the main features of IR are briefly treated. The focus is on how to use a combination of these techniques to identify compounds based on spectroscopic data. Format: Theoretical sessions (three hours each), which are a mixture of lectures and problem solving, and some pure problem solving sessions. Approx. 12 sessions in total. Prerequisites: Knowledge about simple NMR theory typically learned in Organic Chemistry Book: Pavia, Lampmann and Kriz: "Introduction to Spectroscopy" 3rd ed. (Brooks/Cole). Assessment: The course is a pass/non-pass course. In connection with the evaluation of the minimum level of goal achievements, the following is considered: the ability to solve problems related to structures of medium complex organic compounds based on spectroscopic evidence (NMR, Infra Red (IR) and Mass spectrometry). The evaluation is based on the following:

● Answers to three sets of problems, which are handed in individually for approval. ● A final 3 hours test must be passed. All books and notes are allowed.

Physical Chemistry (9 ECTS) Aim: After completing the course successfully, the student is able to draw useful conclusions on the basis of a broad knowledge of physical chemical models and empirical facts, and to analyze and discuss phenomena of a physical chemical nature in a suitable scientific language. Contents: Physical chemistry is treated from a classical, macroscopic, as well as from a molecular, microscopic point of view. The macroscopic aspects include thermodynamics, kinetics, and transport properties of small molecules and macromolecules. The molecular aspects include basic quantum chemistry, chemical bonding and reactivity, molecular symmetry, and molecular spectroscopy (in particular optical spectroscopy). During the course each student will be responsible for the solution of a few problems in class. Format: Class lectures and exercises (problem solving). Volume: Around 30 sessions of three hours. Prerequisites: General Chemistry or the equivalent. Textbook: Peter Atkins, Julio de Paula: “Atkins’ Physical Chemistry”, Ninth Edition, Oxford University Press, 2010 Assessment: The individual problem solving assignments are assessed (pass/non-pass). The answers given on a 4 hours written test in June (re-examination in

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August) dealing with problems in physical chemistry will be assessed according to the 7-step scale. The grading will depend on the extent to which the aims have been fulfilled.

Master courses:

Mandatory Inorganic Chemistry (7.5 ECTS) Aim: After completing the course successfully, the student is able to draw conclusions based upon a broad knowledge of chemical models and empirical facts about inorganic compounds and an extended knowledge of co-ordination compounds when describing and analysing phenomena involving inorganic compounds in a language in accord with tradition in the scientific community. Contents: Inorganic chemistry is treated systematically from a periodic table of the elements point of view. Relevant models are utilized in order to describe the properties of the compounds. Emphasis is put on representative d-block elements, while the f-block elements are only treated superficially. The course is based upon the knowledge of basic inorganic chemistry including its analytical dimension. The laboratory exercises illustrate synthesis and electron-spectroscopic properties of simple coloured co-ordination compounds. The PC-exercise deals with the stability of co-ordination compounds. Format: Each session will be a mix of lecturing, discussions and problem solving in class. A small class size invites to more dialogue with contributions from the participants. Details are to be agreed upon. A few laboratory sessions will deal with the synthesis of simple coordination and a spectroscopic characterisation of the products. Volume: Approx. 25 mornings/afternoons. Each session about three hours. Prerequisites: Inorganic chemistry bonding, spectroscopic methods and elementary chemical thermodynamics and kinetics, and chemical properties of organic compounds with the hetero-atoms O, N and S, especially in aqueous solution. Textbook: C.E.Housecroft & A.Sharpe: Inorganic chemistry. (Prentice Hall) Assessment: The answers given on a 4 hours written test in June (re-examination in August) dealing with a case study in inorganic chemistry with emphasis on coordination chemistry, will be assessed according to the 7-step scale. The grading will depend on the extent to which the aims have been fulfilled. Laboratory- and PC-exercise parts are tested and approved by written reports. Organic Chemistry (7.5 ECTS) Aim: After completing the course successfully, the student is able to draw conclusions based upon a broad knowledge of chemical models and empirical facts about organic

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compounds and a proper knowledge of the principles of organic reaction mechanisms when describing and analysing phenomena involving organic compounds in a language in accord with the tradition within the scientific community. Contents: Organic chemistry is presented in a systematic way on the basis of the principles of organic reaction mechanisms connected with the reactivities of all common functional groups of organic compounds. The identification of reaction products on the basis of knowledge about their preparation, physical properties, and NMR and IR spectra plays a very important part in the theoretical exercises, where also structurally conditioned phenomena such a stereoisomerism, geometrical isomerism, tautomerism, and structural dynamics in general, are thoroughly treated. The laboratory exercises are there to introduce the principles of organic synthesis in practice. Format: A small class size invites to more dialogue with contributions from the participants. Details to be agreed upon. Volume: Approx. 30 mornings/afternoons. Morning sessions (about 26) require 3 hours, while afternoon sessions (4 x laboratory exercises) require 5-7 hours. Prerequisites: Organic chemistry Textbook: M. A. Fox and J. K. Whitesell: Organic Chemistry, 3. Ed., Jones and Bartlett Publ. Assessment: The answers given on a 4 hours written test in January (re-examination in February), dealing with two case studies in organic chemistry with emphasis on understanding (1) structure of organic compounds, (2) nomenclature of organic compounds, (3) the principles of organic reaction mechanisms, and (4) principles for identification of organic reaction products on the basis of chemical and spectroscopic methods, will be assessed according to the 7-step scale. The grading will depend on the extent to which the aims have been fulfilled. The laboratory exercises part is tested and approved by written reports. Synthesis (3 ECTS) Aim: After completing the course successfully, the student is able to work on his/her own hand in the organic synthesis laboratory. Contents: The course is a "learning-by-doing" course, during which the student is trained to obtain an acceptable familiarity with the handling of organic chemicals and organic laboratory equipments. An important aspect of the course is to learn how a reaction (as observed in the laboratory) can be interpreted in terms of a real or supposed reaction mechanism (as formulated in writing), and vice versa. Particular attention is paid to the principles of safety in relation to working in an organic synthesis laboratory. Format and Volume: The course requires 6-7 afternoons/evenings of 5-8 hours duration, depending on the type of synthesis and the skill of the student. Students are encouraged to work together in pairs. Prerequisites: Organic Chemistry or parallel participation in the current course in Organic Chemistry, Teaching materials: to be distributed during the course. Assessment: The course is a pass/non-pass course. In connection with the evaluation of the minimum level of goal achievements, the following is considered:

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The ability to work with organic syntheses independently. The evaluation is based on: ● The successful accomplishment of four relatively advanced organic synthetic preparations, ● Four corresponding professional reports on the synthetic work done, comprising in each case determination of yield, purity, and authenticity of the product obtained, as well as a sufficient spectroscopic characterization.

Elective Computational Chemistry (3 ECTS) Aim: After successful completion of the course, the student will be able to select and apply a variety of computational chemistry models in the study of problems in molecular and bio-molecular chemistry and spectroscopy. Contents: The course will start with a presentation of basic principles in the field of molecular modelling and computational chemistry and an introduction to current software packages (HyperChem, Gaussian). The course ends with a 'mini-project', where each student attempts to solve a particular chemical or spectroscopic problem by using computational chemistry tools. Format: Class lectures, practical computer exercises, and project work. Volume: 10 sessions of three hours. Prerequisites: "Quantum Chemistry and Spectroscopy" (7.5 or 4.5 ECTS) or "Physical Chemistry" (9 ECTS) Textbook: "Computational Chemistry" (compendium), lecture notes, and supporting material on the BSCW. Assessment: The course is a pass/non pass course. The evaluation of the minimum level of goal achievements is based on the ability of the student to discuss, select, and apply adequate computational models in the study of problems in molecular chemistry and spectroscopy. The evaluation is based on successful participation in the exercise program associated with the course, and on the written project report, which is handed in within a time limit of two weeks, and which is presented and defended orally. Bio-organic Chemistry (3 ECTS) Aim: After completion the student is able to solve structural and reactivity problems related to bio-organic problems. Content: The course is teaching central subjects such as amino acids, peptides and proteins, carbohydrates, nucleic acids and lipids. The emphasis is on understanding structure and reactivity. Bio-synthesis is also touched briefly. A strong connection to general organic chemistry and its principles will be seen.

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Compounds and concepts from biochemistry will also be included in the course. Spectroscopic methods (NMR and IR) will be used to understand structure. Format and volume: The course is a total of 10 days of 3 hours. The main course is a mixture of lectures and exercises in class (8 days) combined with 2 days of problem solving. Prerequisites: Advanced organic chemistry and basic knowledge about NMR spectroscopy. This is equivalent to passing the courses Organic Chemistry Basic, Organic Chemistry and Applied Spectroscopy. Textbook: Fox and Whitesell, Organic Chemistry 3. ed. (Jones and Bartlett). Assessment: The course is a pass/non-pass course. In connection with the evaluation of the minimum level of goal achievements, the following is considered: The ability to solve problems related to structure and reactivity issues in bio-organic chemistry based on structural and general organic chemistry theory The evaluation is based on the following:

● Answers to three sets of problems, which are handed in individually for approval. ● A final take home problem dealing with the reviewing of a typical bio-organic problem. The review, which has been handed in within two weeks, shall finally be defended orally.

Microcalorimetry (1,5 ECTS) Aim: This course will enable the student to evaluate the potential of calorimetric methods in research fields including chemistry, technology and life sciences. Contents: The course will include an introduction to calorimetric measuring principles, typical sources of errors and optimization strategies. We will also touch briefly upon underlying thermodynamic theories. The major part will be lectures and student work on case-stories, in which calorimetry is applied to different research fields. Format: Class lectures and one laboratory exercise. Results from the exercise must be presented in a written report and a short oral presentation. Volume: 5 sessions of 3 hours. Prerequisites: General Chemistry and preferably Physical Chemistry. Textbook: Notes on BSCW Assessment: Pass/fail based on: active participation, written report and oral presentation. The minimal requirements are that the student should be able to critically discuss advances and limitations for calorimetry in several scientific fields. This will be evaluated on the basis of the oral presentation, discussions of case-stories and the written report. Kemiske Undervisningsforsøg (4,5 ECTS) (Only in Danish) Formål: Kurset forbereder kommende lærere i Kemi på gymnasieniveau og tilsvarende uddannelser på især det praktiske (eksperimentelle) arbejde.

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Indhold: Indtil 12 studenter kan optages pr. gang. De udfører en lang række velegnede elevforsøg og lærerdemonstrationsforsøg, og præsenterer disse for de øvrige studenter. Derudover diskuteres andre forhold, herunder laboratoriemiljø og –sikkerhed, samt pædagogiske forhold. Format: Kurset strækker sig over 12 uger i hvilke man må regne med at bruge en fuld eftermiddag i laboratoriet hver gang. Herudover er der en del hjemmearbejde, bl.a. rapportskrivning. Forudsætninger: Der er normalt kun adgang for studenter der har bestået 30 ECTS på kandidatdelen af kemi, herunder de obligatoriske kurser Organisk Kemi, Uorganisk kemi og Syntese. Endvidere kræves der et aktivt kendskab til hele gymnasiepensum i Kemi. Dette er en meget vigtig forudsætning! Undervisningsmateriale: Der udleveres noter og gives henvisninger til egnede bøger i løbet af kurset. Derudover vælger hver deltager et bestemt gymnasielærebogssystem, som gennemgås grundigt før og under kurset. Evaluering: Kurset bestås hvis de krævede rapporter er afleveret rettidigt og hvis en timelang praktisk/teoretisk prøve klares tilfredsstillende. Ved denne medvirker kursets lærere og en ekstern censor. Karakterskalaen Bestået/Ikke-bestået benyttes. Biophysical Chemistry (3 ECTS) Aim: After completion the student will be able to apply simple physico-chemical principles for the analysis of the structure, dynamics and interactions of biological macromolecules. Contents: The course will focus on macromolecules and principles of the experimental methods which are used to characterize them. These methods include spectroscopy, spectrometry, chromatography and thermodynamic- and kinetic methods. The course provides a brief introduction to the different classes of biological molecules and their structural hierarchy, purification and structural analysis. Format: Class lectures and problem solving. Further activities are under preparation. Volume: Ten sessions of three hours. In the fall of 2013 the sessions will be on 10 sequential Wednesdays starting Sep. 21st. Prerequisites: Physical Chemistry and Analytical Chemistry (or equivalent). Textbook: van Holde, Johnson and Ho: Principles of Physical Biochemistry, 2nd Ed. Pearson (2006). Assessment: The course is a pass/non-pass course. In connection with the evaluation of the minimum level of goal achievements, the following is considered: The ability to apply simple physico-chemical principles for the analysis of the structure, dynamics and interactions of biological macromolecules. The evaluation is based on an individual oral examination. Bioinorganic Chemistry (3 ECTS)

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Aim: After having completed this course successfully, the student is able to discuss structural and other features of possible interactions and roles of metal ions and other inorganic species in biological systems. Contents: The course will deal with a number of examples of metal ion interactions with biologically relevant molecules and will go into detail with a few cases. Breathing will be taken as an example. The course will draw upon some biochemistry and upon empirical facts, concepts and models in inorganic chemistry and expand coordination chemistry models and methods to be used in more complicated systems. Volume: 10 sessions of three hours. Format: Lectures and exercises in class and case studies. Prerequisites: Inorganic chemistry, properties of polyfunctional organic molecules. Textbook and teaching material: To be announced Assessment: The course is a pass/non pass course. In connection with the evaluation of the minimum level of goral achievement, the following is considered: The ability to discuss interactions of metal ions and other species in biological systems and the use of a number of relevant models and methods to describe such systems. The evaluation is based on a written report which is handed in within a time limit and presented and defended orally. 2D NMR (3 ECTS) Aim: After completion of the course successfully, the student is able to solve structures of complex organic molecules bases on 2D NMR spectra. Contents: The theme is 2D NMR techniques for assignment of 1H and 13C NMR spectra (13C is an example and could as well be other nuclei such as 15N, 19F, 31P etc). Techniques such as COSY, TOCSY, INEPT, INADEQUATE, HETCOR and others are treated and exemplified. In addition, techniques for structure determination of biomolecules such as NOESY and ROESY are discussed. The approach is practical, but some techniques will also be treated theoretically. Practical details regarding recording of spectra will be discussed as well as interpretation of spectra. Format: The extent is 10 x 3 hrs. Seven days of mixed lectures and exercises and three days of problem solving. Prerequisites: Applied Spectroscopy Textbook: Nuclear Magnetic Resonance Spectroscopy, An Introduction to Principles, Applications and Experimental methods, J.B. Lambert and E.P. Mazzola (Pearson Prentice Hall 2004). Assessment: The course is a pass/non-pass course. In connection with the evaluation of the minimum level of goal achievements, the following is considered: The ability to solve problems related to structures of complex organic molecules based on 2D NMR spectroscopic evidence. The evaluation is based on the following:

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● Answers to three sets of problems, which are handed in individually for approval. ● A final take home problem. The written solution, which has been handed in within a time limit of one week, shall be defended orally.

Electro spray Mass spectrometry- LC-MS (1.5 ECTS) Aim: After completing the course successfully, the student is able to analyse and discuss data from LC-ESI-MS experiments in various applications. Contents: The most important modern ionizations methods, the theory of different mass analyzators, molecular weight and sequence determinations of peptides and proteins, a LC-MS laboratory assignment. Format: Lectures with discussions and exercises and laboratory assignment Volume: 5 sessions of three- four hours Prerequisites: Instrumental Analytical Chemistry, Applied Spectroscopy and Physical chemistry. Teaching material: E. de Hoffmann and V. Strobant: Mass Spectrometry, Principles and Applications, Wiley 2002 and M. Kinter and N. E. Sherman: “Protein Sequencing and Identification Using Tandem Mass Spectrometry” Wiley-Interscience, New York 2000. Chapters 2-4, and Daniel C. Harris: “Quantitative Chemical Analysis” 7 ed. 2007 Chapter 22. Assessment: With the student having participated actively in the laboratory assignment, the student is assessed on the basis of the written report and on an oral presentation of a selected LC-MS topic, devised by the lecturer. Pass is given for the report and the oral presentation demonstrating that the student to a limited but sufficient extent is able to discuss data and techniques in LC-ESI-MS experiments.

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Regulation of assessments of courses

1. The three courses, Physical chemistry, Organic Chemistry and Inorganic Chemistry are assessed by a written 4-hours open book individual test. Personal notes, textbook material and a calculator may be used. The courses are graded according to the 7-point grading-scale. An external and an internal examiner (normally the teacher of the course) are grading the tests.

Prior to the written test, a qualifying assessment is performed by the internal examiner. Here practical work and reports are assessed. The grading system is: passed/not passed.

2. The course "Experimental School Chemistry" is assessed by an oral/practical test. The given problem is illustrated by practical demonstrations by the student. The student has three hours to set up the chemical demonstration. The language is Danish. The course is graded according to the 7-point grading-scale. An internal (normally the teacher of the course) and an external examiner is used.

Before the written test, a qualifying assessment is performed by the internal examiner. Here practical work and reports are assessed. The grading system is: passed/not passed.

3. Other courses are assessed by an internal examiner and may be based on one or

more of the following elements: ● a final written test ● a final oral test ● take-home problems ● reports on experimental assignments ● seminars given by participants

The assessment method is given as an element in the description of the course.

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Signing up for courses and examinations

To participate in the chemistry courses at the bachelor- or master levels, you have to register in STADS self-service. The STADS self-service is to be found on www.ruc.dk under “portalino.” You can read more about it in the following section. When you sign up for a course in STADS you will automatically be registered for the examination of the course. As a consequence of this you have to cancel your examination through the secretary to the Study Board of Chemistry at the latest three days before the examination date if you don’t wish to take the examination. If you don’t remember this you will have lost one attempt. For the fall semester 2013 you have to register between: Bachelor Courses: 2nd September – 13th September Master Courses: 15th August – 31th August. Projects: 15. September - 1. October Remember to sign up in time!!

Examination dates*:

Winter exam 2013/14 Chemistry: Bachelor courses: Internal examination in Applied Spectroscopy will be announced by the supervisor during the fall semester.

Master courses Written examination in Organic Chemistry – 6th January Re-examination in Organic Chemistry – 3rd February Project exams will be in the period 20 to 31 January 2014. Summer exam 2014 Chemistry: Bachelor courses: Written examination in Physical Chemistry – 2nd June Re-examination in Physical Chemistry – 27nd August Master courses: Written examination in Inorganic Chemistry – 17th June Re-examination in Inorganic Chemistry – 29th August Project exams will be in the period 18 to 30 June 2014.

Re-examination

Be aware that you will not be able to attend the re-examination unless you have participated in the ordinary examination. Only if you haven’t been able to participate due to documented illness you can be released from this rule. * Changes may occur

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Karaktergivning

Kapitel 1 (af Karakterbekendtgørelsen gældende fra 1. september 2007) 7-trins-skalaen m.v.

§ 1. Studerende skal ved prøver, der indgår i eksaminer, og ved prøver i enkeltfag bedømmes individuelt efter følgende karakterskala (7-trins-skalaen), jf. dog stk. 3 og 4: 12: For den fremragende præstation 10: For den fortrinlige præstation 7: For den gode præstation 4: For den jævne præstation 02: For den tilstrækkelige præstation 00: For den utilstrækkelige præstation -3: For den ringe Præstation § 2. Karakteren 12 gives for den fremragende præstation, der demonstrerer udtømmende opfyldelse af fagets/fagelementets mål, med ingen eller få uvæsentlige mangler. § 3. Karakteren 10 gives for den fortrinlige præstation, der demonstrerer omfattende opfyldelse af fagets/fagelementets mål, med nogle mindre væsentlige mangler. § 4. Karakteren 7 gives for den gode præstation, der demonstrerer opfyldelse af fagets/fagelementets mål, med en del mangler. § 5. Karakteren 4 gives for den jævne præstation, der demonstrerer en mindre grad af opfyldelse af fagets/fagelementets mål, med adskillige væsentlige mangler. § 6. Karakteren 02 gives for den tilstrækkelige præstation, der demonstrerer den minimalt acceptable grad af opfyldelse af fagets/fagelementets mål. § 7. Karakteren 00 gives for den utilstrækkelige præstation, der ikke demonstrerer en acceptabel grad af opfyldelse af fagets/fagelementets mål. § 8. Karakteren -3 gives for den helt uacceptable præstation.

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Grading

7-point grading scale 1. Students shall in tests and examinations, which according to the rules on the individual study programmes etc. shall be documented by test, examination or leaving certificates, be given an assessment according to the following grading scale (7-point grading scale), cf., however, Part 2: 12: For an excellent performance. 10: For a very good performance. 7: For a good performance. 4: For a fair performance. 02: For an adequate performance. 00: For an inadequate performance. -3: For an unacceptable performance.

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Projects

The project work of the bachelor module is intended to give insight into chemistry as a tool applied to a biological, geological, chemical or technological problem. Analytical techniques will most often be used for such purposes, and the techniques should be used professionally. In the master programme project work is intended to give insight into models and methods and research in chemistry. Understanding will in most cases be a key word. Project work is concluded by a written project report, which is presented and finally defended. Each report has to include an abstract in English.

Oral project exam

The guidelines for oral exams are described in “the common rules for the university.” Rules in study regulations of September 1, 2003 repeat and exactly state that the project report has a status as a starting point for the discussions at the examination. Project reports are naturally of varying quality. An examiner and an external examiner (external opponent) could be inclined to fail students in cases where the students have written a poorly organized, sloppy written and otherwise faulty report. On the other hand examiner and external opponent could determine that an accurately written and well-organized report should be given high marks. But it is not allowed that the quality of the report should be decisive for the grade alone. One consideration is that the evaluation must be individual and that the quality of the report is evident of the quality of the work the individual students has put into it. One might say that the quality of the report is the starting point from which the final grade most likely will be given, but it cannot be ruled out that the final evaluation will be based solely on the individual oral presentation. A thorough description on the status of the report is available in the following note: http://www.ruc.dk/ruc/internesider/regelsamling/Notatprojekt The examination lasts 30 minutes per student at most and is led by the examiner. There are no rules for the structure of the oral exam. Normally, the student begins the exam with a short 5-7 minutes individual presentation in relation to the report. Such a presentation could include:

• An elaboration of chapters in the report that is difficult to understand because parts of the report are faulty or incomplete.

• A presentation of new results obtained after the report was handed in. • A perspective on the obvious continuation of the current project. • A specific question given by the examiner, if he or she and the group have

agreed upon this procedure

In all cases the exam is held in a relaxed atmosphere, where the external examiner may ask questions to details and points in the report or individual presentation, and also give further feed back to the project work.

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Project market During the first two weeks of all semesters a project market is being held usually including meetings. Here students agree on and form groups around topics and projects with a co-ordinated supervisor. During the first meeting students usually present some of their ideas and experiences and the supervisors present their on-going research, inform about previously supervised projects and present suggestions for new project ideas. Afterwards the director of studies will guide the students until all the groups have been established. Usually the students have 2-4 projects of interest and discuss with other students with similar interests and potential supervisors. The group sizes are about 4 students. If students and a supervisor already have established a group around a certain project this project is also presented at the project market for other students attending the project market, usually by student members of the project group. At the next meeting(s) the director of studies assists in forming the final groups. The supervisors have about 30 hours per student for supervision of a (15 ECTS) project at bachelor and first candidate modules. This includes time for exam, establishment of the project, evaluation etc. To exploit the resources of the supervisors the best, each group has a maximum of 95 hours per project. A supervisor of students doing their master project (30 ECTS) has 50 hours per student. As soon as all of the project groups have been established they have to fill in a registration form with title of the project, names of the supervisor and the students. The proposed project will have to be approved and signed by the director of studies. As already stated, the project report has the status as a starting point for the discussions at the oral examination. In addition, one of the two bachelor module reports (i.e. related to one of the individual student's two subjects) acts as a bachelor thesis. Likewise, one of the master project reports (30 ECTS) or integrated reports (30 or 60 ECTS) acts as the master thesis. In addition to the normal assessment based on the oral defence, a thesis is also assessed in its own, as a professional report.

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Experimental projects Most projects in chemistry are experimental and a registration form regarding laboratory safety has to be filled out by the students and the supervisor at the start of the project work. The students are informed about possible dangers in the specific laboratory e.g. handling and correct disposal of poisonous substances/compounds or devices to be handled with special attention. The registration form for laboratory safety is available at the secretary of the chemistry Study Board.

The Master Thesis and the master project (30 or 60 ECTS).

New time limits for thesis work have been introduced. This means a more rigorous administration: Procedure

1. The student fill in a Preliminary Thesis Form specifying the preliminary area of study, the name of the preferred supervisor and a preliminary starting date

2. The Preliminary Thesis Form is registered in the secretariat and the student

receives a letter of acceptance that the specification of the area of study has to be completed assisted by the supervisor within a specified time limit (normally one month). This work has been formulated as a description of the thesis work as a short synopsis and a preliminary time table for the accomplishment for the project.

3. When the synopsis, the time table and the supervisor have been approved by

the director of studies (normally within a week from receiving the specifications according to 2. above) the approved material is sent to the supervisor, which is urged to help the student to keep on track and obey the complete the work within the time limit.

4. The student gets a "go" - a copy of the material which is sent to the supervisor

together with a deadline for the Thesis to be handed in. Included is also a deadline for presenting a written application (with very good reasons) for not being able to complete the studies according to the plan.

5. The documents are filed in the secretariat.

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Specialer og kandidatprojekter (30 og 60 ECTS)

Der er indført krav om at specialer gennemføres inden for bestemte tidsfrister. Det betyder en lidt strammere papirgang: Procedurer omkring specialer:

1. Den studerende udfylder en blanket med tentativ angivelse af specialeområde (titel på projekt) og den ønskede vejleder, samt et foreløbigt igangsætningstidspunkt.

2. Interessetilkendegivelsen registreres i SN-sekretariatet, og den studerende

modtager brev om, at arbejdet med at præcisere projektemnet i samarbejde med den ønskede vejleder skal afsluttes (normalt inden for en måned, jf. meddelelsen om igangsætningstidspunkt) og resultere i en egentlig specialetilmelding i form af en kort synopsis og en foreløbig tidsplan for gennemførelse af specialeprojektet.

3. Når synopsis, tidsplan og vejlederen er godkendt af studielederen (normalt

senest en uge efter aflevering i henhold til punkt 2), sendes det godkendte materiale til vejlederen. Vejlederen får desuden en klarmelding til at gå i gang og en opfordring til at hjælpe den studerende med at overholde halvårsfristen. Desuden fremsendes tillige sikkerhedsblanketten, som skal afleveres i SN-sekretariatet med den studerendes og vejlederens underskrift på, at de har gennemgået de sikkerhedsmæssige aspekter af laboratoriedelen af specialearbejdet.

4. Den studerende får en klarmelding (kopi af brev til vejlederen) til at gå i gang

og en frist for aflevering af specialerapport, vedføjet en frist for evt. at indlevere en velbegrundet ansøgning om at få forlænget fristen.

5. De anførte dokumenter og meddelelser i sagen opbevares i SN-sekretariatet.

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Projects completed in 2012/13

“Title” (supervisor) Students

”Adsorption properties and deactivation of cellulase.” (Peter Westh) 2

”Kinetic Study of Cyclodextrin-Bile Salts Inclusion Complexes.” (Peter Westh)

3

“Syntese og acylering af Thiazolo [3,2-a]benzimidazol-3-on.” (Fritz Duus) 30 ECTS Master project

1

“Synthesis of bipyrimidine ligands for Ru-dyes useful for dye-sentized solar cells.” (Torben Lund)

3

“Glass transition in Richterius Coronifer and water-trehalose systems.”(Peter Westh)

2

Master thesis Søren Storm “Deformation of Pluronic Gels.” Søren Hvidt and Thomas Schrøder Line Bergmann “Heterogenous Precipitation of Bariium Sulphate” John Mortensen And Tage Christensen Biljana Mojsoska “Peptide inderference with amphotropic Murine Leukemia virus entry by macropinocytosis and peptide-glycosaminoglycan interaction studies using affinity chromatography and capillary electrophoresis” Torben Lund Johan Olsen and Jeppe Kari “The Processive Mechanism of TrCel7A studied by Rational Design. Design, expression purificaton and characterization of TrCel7A variants” Peter Westh and Tove Atlung Thomas Allan Rayner “Comparative Biochemical Profiling of Tropical and Boreal Calanoid Copepods” John Mortensen

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Applications for Credit Transfer

As a part of your education you may take courses and do projects at other institutions than RUC, e.g. at other Danish universities or in connection with studies abroad. However, before external studies are initiated you must apply for acceptance from the Study Board. Applications must include a description of the course/project i.e. its content, evaluation, ECTS points etc. Careful planning is necessary before the external study, and after you have completed the external study you must reapply for a real transfer credit. The guide lines for approval of credit transfer applications are briefly summarized here: Physical Chemistry, Organic chemistry, Inorganic chemistry and Synthesis at RUC may be replaced by a course at another university, if the course is equivalent to a course at RUC with respect to content, volume and level. The course must cover the same topics as the course at RUC. The same number of ECTS points given for the course at RUC according to the Study Rules will be given even though the course is given more ECTS points at the other university. An elective course can be replaced by a course at another university if a similar course could have been offered within the Study Rules at RUC. Group 3 courses are typically smaller volume courses which can offer a broader insight into topic areas in chemistry. For this reason an external course can usually not be credited with more than 4.5 ECTS points at RUC, Thesis work can be performed partially or entirely other places than at RUC. However, the evaluation must take place at RUC. An internal RUC supervisor is appointed to such thesis work and this supervisor is responsible for the examination. Projects, which are not thesis work, have three options: A) In connection with studies abroad a project or an independent problem assignment in connection with a course may replace a project at RUC. Project must, however, fulfill the module requirements. B) A project at another university in Denmark may be credited at RUC, if the project contains appropriate formulations in accordance with a module requirement. It is possible to apply to the Study Board for pre-approval. C) An internal RUC supervisor is appointed if a project is performed at a research institute or in a research/development laboratory. The internal supervisor is responsible for the examination. This, however, is not a genuine transfer case but merely that experiments or similar are conducted at another place than RUC. Contact the Chemistry Study Board if you need further information.

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Studieophold i udlandet (only in Danish)

(Study visit abroad) Der er mange muligheder for kemistuderende at læse i udlandet. Hvis du overvejer at læse et semester i udlandet bør du starte med at skaffe et eksemplar af pjecen "Studieophold i udlandet" fra Det Internationale Kontor, hvor de generelle betingelser og muligheder for RUC-studerende, der ønsker at læse i udlandet, beskrives. Heri findes blandt andet en oversigt over de forskellige netværk og udvekslingsprogrammer RUC deltager i. Et udlandsophold skal planlægges i god tid for at få det bedste udbytte. Du skal selv skaffe oplysninger om studieforholdene på det fremmede universitet, lægge et forslag til studieprogram og opnå et forhåndstilsagn på dette. Se gode råd i pjecen ”Studieophold i udlandet”. European Community Course Credit Transfer System (ECTS) er et system til internationalisering af studierne i Europa. Flere og flere universiteter i Europa beskriver deres (kemi-) studier i en ensartet form, så det bliver lettere at se på forhånd hvad indhold, form, varighed, omfang og niveau en bestemt studieaktivitet har på det pågældende universitet. Meningen er at gøre det lettere at overskue at tilbringe en periode (typisk et semester eller et helt år) ved et udenlandsk universitet, og vide på forhånd hvad de planlagte studieaktiviteter (European Community Course) kan erstatte (Credit Transfer) på ens eget universitet. Europakommisionen har afsat penge til hjælp til rejser og ophold for at kunne fremme internationaliseringen (Sokrates programmet). Studienævnet for kemi har etableret følgende SOKRATES/ERASMUS-nætværk:

● Freie Universität Berlin ● Justus-Liebig-Universität Giessen ● University of Ljubljana

Kontakt netværkskoordinator Håvard Jenssen (hus 17.2, jenssen@ruc.dk), hvis du vil høre mere. Studienævnet modtager endvidere løbende materiale om udvekslingsaftaler. Dette bliver slået op på opslagstavlen i 17.2. Du kan via Kemi-SN søge internationaliserings-stipendium (søges via Kemi-SN). Puljen kan også søges til andre ophold end til ERASMUS-aftaler. Hertil kommer evt. SU-stipendium. Ansøgningsfrister er ca. 1. maj hvert år for det kommende studieår og opholdet skal derfor planlægges i løbet af foråret. Evt. overskydende stipendier kan søges løbende. Hvis man ønsker at studere andre steder er det en god ide at kontakte den/de vejledere, der er fagligt nærmest det man ønsker at lave for at undersøge, hvilke

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muligheder og kontakter, der findes. Endvidere kan studielederen orientere mere præcist om de konkrete muligheder. Henvendelse angående studenterrejser og rejsekonto rettes til studienævnet. Læs mere om muligheder for udveksling på http://www.ruc.dk/ruc/uddannelse/udveksling/udland-mulighed/ Aktiviteter uden for RUC Eksterne projekter: Det vil især være vejledere NSM, der gennem deres personlige forbindelser uden for RUC kan formidle kontakt til virksomheder, hvor studerende kan arbejde med et eksternt specialeprojekt.

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Chemistry staff

Poul Erik Hansen (Professor) Mail 18.1, phone 4674 2432. E-mail: poulerik@ruc.dk. Home-page: http://www.ruc.dk/~poulerik Scientific interests: My research is centered around structural studies of organic compounds, biomolecules and natural products mostly using nuclear magnetic resonance (NMR). A central part of these studies include the use of isotope effects. In structural studies emphasis is on compounds with hydrogen bonds or compounds taking part in tautomerism. The studies of biomolecules have been concentrated on proteins, peptides, porphyrin degradation products, carbohydrates, nucleic acids and cell erythrocytes, nerve cells and plant cells). Other studies using NMR is protonation of polycyclic aromatic hydrocarbons (PAH), substituted PAH and the relation to cancer. NMR has also been used in environmental studies especially in studies of humic acids and binding of xenobiotics to those. In molecular biology contexts NMR is especially useful in structural studies of proteins, nucleic acids and binding of ligands to those. For more information about our research see the home-page. Teaching: Organic Chemistry Applied Spectroscopy 2D NMR spectroscopy Bioorganic chemistry Protein Chemistry Projects: The subjects of the projects have typically fallen among those mentioned above. Peter Westh (Professor) Mail 18.1, phone 4674 2879, E-mail pwesth@ruc.dk Research area. Our research group works within the area biophysical chemistry. More specifically we analyze biomolecular interactions and the physical stability of biomolecules. While our emphasis is on experimental investigations we also utilize theoretical and computational techniques. Our laboratory is specialized in thermodynamic methods

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such as calorimetry, densitometry and vapor pressure measurements, but our research projects also include spectroscopic, scattering and chromatographic measurements conducted in collaborating institutions. Currently we are engaged in four research projects entitled

● Small molecules in lipid membranes: Physical properties and biological implications.

● Thermodynamics in Biotechnology: Stability and activity studies ● Calorimetry in basic biology: Sensing the heat of metabolism. ● Hydration studies: The interaction of water with biopolymers and small

model compounds.

Fritz Duus (Emeritus Assoc. Professor) Mail 18.1, phone: 4674 2434, E-mail: fd@ruc.dk Scientific interest: Supervision is offered within all aspects of organic chemistry, provided that the subject is of scientific interest and the project can be realized within the settings of the chemistry programme. Of general interest are organic compounds exhibiting tautomerism or other types of structural dynamics, especially when the structural characteristics can be analysed by spectrochemometrics. Of particular interest are organic sulphur compounds with interesting structural qualifications, e.g. sulphur analogues of β-dicarbonyl compounds, desaurins, rhodanines, and other heterocyclic compounds containing sulphur. The projects will typically include organic synthesis, spectroscopic characterization (NMR, IR,UV/VIS), application of spectrochemometrics, and simple theoretical gateways to molecular characterization. Areas of teaching: Organic Chemistry Synthesis Søren Hvidt (Assoc. Professor) Mail 18.1, phone 4674 2477, E-mail: hvidt@ruc.dk Homepage: http://www.ruc.dk/~hvidt Project and research areas:

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I have supervised projects in which physical chemistry is used to investigate problems in Chemistry or in inter-disciplinary projects with Physics and Biology. Several projects have been centered around the interactions of water with molecules which consist of both hydrophilic and hydrophobic parts. Such systems often form micelles and gels. Micellization and gelation can be monitored by rheological methods, in which the elasticity and viscosity is measured as a function of e.g. time or temperature. Calorimetric methods, HPLC, surface tension, and NMR are often used to characterize polymers and copolymers, and also to investigate interactions with water. Current research interests include solubility properties of small ethers in water. Tri-block copolymers of ethylene glycole and propylene glycole are studied by several techniques, and the factors in blood which can regulate the properties and structure of fibrin gels are investigated by rheological methods. Areas of teaching: General and Physical Chemistry Polymer Chemistry and Physics Biophysical Chemistry Jens Josephsen (Assoc. Professor) Room: 17.2-047, mail 18.1; phone 4674 2415, E-mail: phjens@ruc.dk Scientific interests: My interests are in co-ordination chemistry and chemical education. Environmental or health aspects of metal ions have often been a motivational factor for students to undertake projects in the co-ordination chemistry area. During the process the students have directed their attention towards a specific chemical problem with a biological perspective or physiological relevance. How a specific metal ion behaves with a biological object or a bio-molecule has often been the focus in such projects. The work has included synthesis and the characterisation of the products by spectroscopic methods and the study of reactivity and stability. The relevant chemistry of platinum(II) in cancer chemotherapy has been the subject of several projects. Lately an increasing part of my attention has been in chemical education studies. I have focussed on IT in teaching with a practical approach (teaching programmes) as well as a didactical approach (what should be used, how does it work, and why). Teaching areas and courses: General chemistry Inorganic Chemistry (basic and advanced) Projects Torben Lund (Assoc. Professor)

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Mail 18.1, phone 4674 2472/ 4674 2541, E-mail: tlund@ruc.dk Research: My research interests are in the fields of photo electrochemical cells, physical organic chemistry, organic electrochemistry, photo chemistry, and analytical chemistry. During the last 3-4 years I have focused on the investigation of dye degradation chemistry of the nano crystalline TiO2 dye sensitized solar cells (Grätzel cells) and the mechanism of the electro polymerisation process of pyrrol. These investigations have involved careful product analysis of complex dye degradation mixtures by chromatographic and electro spray mass spectrometric methods (LC-ESI-MS) in combination with measurements performed with electro analytical and photochemical equipments. I have furthermore been involved as an analytical chemist in several environmental biology projects in collaboration with biologist from this and other Danish Departments. These projects have involved LC-MS analysis of pigments in water plants and GC-MS analysis of steroids and fatty acids in marine organisms. Teaching Organic Chemistry Basic Instrumental Analytical Chemistry LC-MS Protein chemistry Projects

John Mortensen (Assoc. Professor) Mail 18.1, phone 4674 2473, E-mail john@ruc.dk Research: My main research activities are within electrochemical analysis. Here I am working with dynamic methods such as cyclic voltammetry for characterisation of organic redox reactions and stripping voltammetry for the determination of trace levels of heavy metal ions. I also work with chemical sensors (Ion-selective electrodes) in a multi sensor setup (Flow injection) with multivariate data treatment where cross sensitivity is used as an advantage. In the last two years, I work with the development of new sensors based on polymers mainly of thiophene. The goal is to make sensors with different sensing characteristics for determining of ions in solution and for sensing of gas in gas mixtures. Teaching: Inorganic Chemistry Basic Instrumental Analytical Chemistry Projects

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Jens Spanget-Larsen (Assoc. Professor) Mail 18.1, phone 4674 2710, E-mail spanget@ruc.dk Homepage: http://www.ruc.dk/~spanget Scientific Fields: Molecular aspects of Physical Chemistry, in particular Optical Spectroscopy and Quantum Chemistry. - The spectroscopic projects focus on UV-VIS and IR polarization spectroscopy on ordered molecular systems. Partially aligned molecular samples are obtained in a simple fashion by The application of stretched polymers (polyethylene, polyvinylalcohol) as anisotropic solvents. The investigations lead to determination of molecular polarization directions (transition moment directions), information that is of importance in the assignment of spectroscopic transitions and in the study of molecular structure and symmetry properties. A wide selection of compounds have been investigated, particularly compounds with dynamic structural properties (keto-enol tautomerism, valence tautomerism, intramolecular hydrogen bonding). Also optical investigations of chemical reactions have been carried out, such as complex formation and hydrogen bonding equilibria. - The quantum chemical projects are closely related to the spectroscopic investigations and deal with development and application of efficient theoretical models for the description of molecular structure, reactivity, and optical transitions, i.e., electronic and vibrational excitations. But also other aspects have been investigated, there are many possibilities. Teaching areas: - Optical Spectroscopy (UV-VIS-IR) - Quantum Chemistry - Molecular Modelling - Computational Chemistry Kjeld Schaumburg (Adjunct professor) Mail: 18.1, phone 4674 2533, E-mail: ksch@ruc.dk Homepage: http://www.cismi.dk/ Projects and research areas: Project and research areas: I have supervised projects in which physical chemistry and spectroscopy are used to investigate problems in Chemistry or Materials science. Several projects have been focussed on the influence of high pressure on processes in chemistry and biology. Especially the use of supercritical CO2 used for synthesis of materials and for drying of aerogels are of interest for me. Most of my activities are directly related to solution of problems initiated in Danish industry.

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Areas of teaching: NMR spectroscopy Materials science Sol-Gel Chemistry Biophysical Chemistry Erik W. Thulstrup (Professor emeritus) Mail 18.1, E-mail: ewt@ruc.dk Scientific interests: My science field is optical spectroscopy (UV, visible, IR) performed on ordered systems (liquid crystals, stretched polymers, macromolecules aligned in a flow, etc.). The spectra are recorded with polarized light, which may give extensive structural information. Theoretical aspects of the work include assignment of vibrational and electronic transitions, as well as mathematical descriptions of the alignment in ordered samples. I am the author of the leading textbooks in the field. There are many practical applications of my research, from basic cancer research and liquid crystal displays to quality control of carpet fibers. Another area of great interest for me is the role played by science, technology, and higher education in the developing world. Teaching: Physical Chemistry Projects

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Technical employees

Annette Christensen Address 17.1, phone: 4674 2429 / 4674 2288 / 4674 2930 E-mail: acis@ruc.dk Laboratory technician, chemistry and safety consultant Operations NMR and AAS. Eva Karlsen Address 17.1, phone 4674 2429/ 46742773 E-mail: ekarlsen@ruc.dk Laboratory technician, chemistry Operation of UVVIS, HPLC, IR and AAS Niels-Jacob Krake Address 17.1 phone: 4674 2429/ 4674 2423 E-mail: krake@ruc.dk Laboratory technician, chemistry and biology Operation of CNN Oda Brandstrup

Address 27.1, phone: 4674-2678 E-mail: odab@ruc.dk Laboratory technician, chemistry and physics

Ph.D. students and Post-doctoral fellows

In addition to the permanent staff several PhD students and post-docs are doing their research and some teaching at the Department.

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Administrative employees in the Department of Science, Systems and Models in 18.1+2

Louise Damgaard Jensen Address 18.1. phone: 4674 2544, E-mail: lodaje@ruc.dk Ph.D. secretary and secretary for the research groups for Chemistry and Biology ______________________________________________________________

Pia Sander Address 18.1, phone: 4674 2422, E-mail: psander@ruc.dk Secretary to the Study Board of Biology and Study Board of Chemistry Margit Christiansen Address 18.1 , phone: 4674 2050, E-mail: macr@ruc.dk Head of secretary

Information for Students at the Department of Science, Systems and Models concerning Safety.

Please note that as a student at the Department of Science, Systems and Models you have a responsibility for your own safety and for the safety of others when working in the laboratory. The Department provides approved laboratories that comply with safety regulations for the students to work in, (however no requirements or inspection procedures regulate which chemicals, equipment or experimental procedures students use in their daily work.) In regard to the way you conduct your work in the laboratory, you are subject to the same rules and regulations as the employees at the Department. Safety is also your responsibility: At some point during your education at the Department of Science, Systems and Models you will probably work with chemicals that pose a health or safety hazard. It is your responsibility to obtain and study any relevant information on potential health and safety hazards posed by the chemical you intend to use, before starting any work involving that chemical. Before using it, it is your responsibility to inspect whether any experimental apparatus is correctly assembled using the correct components. If necessary, ask a supervisor or laboratory technician to inspect and approve the apparatus. It is your responsibility to thoroughly evaluate the possible hazards connected to a new experimental procedure, before performing it.

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You should not expect that your supervisor informs you of all relevant health and safety aspects of your work in the laboratory. You can expect that your supervisor will advise you on health and safety aspects concerning a new experimental procedure, if you ask for such advice. However you should be the one who takes the initiative on these matters.

Advice: Always perform an analysis of the risks involved prior to performing any new procedures in the laboratory – if you have any doubts or questions then contact your supervisor or the technician affiliated to your laboratory. If you are pregnant, you should always inform your student advisor, project or course supervisor as soon as possible, in order to implicate the necessary precautions. (Link to RUC employee policy and www.at.dk/sw5813.asp - At-guidelines on the Working Environment of Pregnant Women – February 2002). In cooperation with the Safety Committee, your supervisor is responsible for ensuring that any laboratory work is performed in such a way that it does not pose a risk to the development of your child. On her part the pregnant woman is obligated to cooperate with employees and/or students in ensuring a safe working environment and to follow any special guidelines. Preschool children are not allowed in the laboratories. Remember to stop and think before it is too late! Published by: Safety Committee in August 2005