Departemen Departemen HistologiHistologi

Basic Science

Introduction

Introduction cont’d

Membrane proteins

Membrane proteins

Cytoskeletons

Extracellular MatrixExtracellular matrix: a complex of nonliving macromolecules

manufactured by the cells & exported into extracellular space. Macromolecules fibronectin, laminin, etc.

Cell Junctions Classification:

Cell Junctions Map:

1. Occluding Junctions Tight Junctions

2. Anchoring Junctions

2. Anchoring Junctions cont’d

Zonula Adherens

The folding of an epithelial sheet to form an epithelial tube The oriented contraction of the bundles of actin filaments running along adhesion belts

causes the epithelial cells to narrow at their apex and helps the epithelial sheet to roll up into a tube. An example is the formation of the neural tube in early vertebrate development. Although not shown here, rearrangements of the cells within the epithelial sheet are also thought to have an important role in the process

2. Anchoring Junctions cont’d

2. Anchoring Junctions cont’d

Autoimmune disease disrupt desmosomes blistering of skin

2. Anchoring Junctions cont’d

2. Anchoring Junctions cont’d

3. Communicating JunctionsGap Junctions

Gap Junctions Cont’d

Cell JunctionsSummary

Cell JunctionsSummary cont’d

References 1. Molecular Biology of the Cell, 4th edition, Bruce

Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, and Peter Walter, New York: Garland Science; 2002.

2.2. Basic Histology Text & Atlas , 10th ed. , L. Carlos Basic Histology Text & Atlas , 10th ed. , L. Carlos Junquira MD, Jose Carneiro MD, Robert O. Kelley Junquira MD, Jose Carneiro MD, Robert O. Kelley PhD, Lange Medical Books, Mc Graw-HillPhD, Lange Medical Books, Mc Graw-Hill

3. Histology and Cell Biology: an Introduction to Pathology, Epithelium, 2nd edition, Abraham L. Kierszenbaum M. D. Ph. D, Mosby Elsevier Inc. 2007, Philadelphia.

4. Functional Ultrastructure Atlas of Tissue Biology and Pathology. Margit Pavelka, Jürgen Roth. 2005. Springer-Verlag/Wien. NewYork.